CN1370236A - Corynebacterium glutamicum genes encoding proteins involved in memberane synthesis and membrane transport - Google Patents

Abstract

Isolated nucleic acid molecules, designated MCT nucleic acid molecules, which encode novel MCT proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing MCT nucleic acid molecules, and host cells into which the expression vectors have been introduced. The invention still further provides isolated MCT proteins, mutated MCT proteins, fusion proteins, antigenic peptides and methods for the improvement of production of a desired compound from C.glutamicum based on genetic engineering of MCT genes in this organism.

Description

Corynebacterium glutamicum genes encoding proteins involved in membrane synthesis and membrane transport

RELATED APPLICATIONS

This application claims priority from U.S. provisional patent application serial No. 60/141031, filed on 25/6/1999. This application also claims priority from the following patent applications: german patent application No. 19931454.3 applied on 8/7/1999, German patent application No. 19931478.0 applied on 8/7/1999, German patent application No. 19931563.9 applied on 8/7/1999, German patent application No. 19932122.1 applied on 9/7/1999, German patent application No. 19932124.8 applied on 9/7/1999, German patent application No. 19932125.6 applied on 9/7/1999, German patent application No. 19932128.0 applied on 9/7/1999, German patent application No. 19932180.9 applied on 9/7/1999, German patent application No. 19932182.5 applied on 9/7/1999, German patent application No. 19932190.6 applied on 9/7/1999, German patent application No. 19932191.4 applied on 9/1999, German patent application No 19932209.0 applied on 9/7/9/1999, German patent application No. 46 19932212.0 applied on 9/1999, German patent application No. 19932227.9 applied on 7/9/1999, German patent application No. 19932228.7 applied on 9/7/1999, The German patent application No. 19932229.5 applied in 99070, the German patent applicationNo. 19932230.9 applied in 7/9/1999, the German patent application No. 19932927.3 applied in 7/14/1999, the German patent application No. 19933005.0 applied in 7/14/1999, the German patent application No. 19933006.9 applied in 7/14/1999, the German patent application No. 19940764.9 applied in 8/27/1999, the German patent application No. 19940765.7 applied in 8/27/1999, the German patent application No. 19940766.5 applied in 8/27/1999, the German patent application No. 19940830.0 applied in 8/27/1999, the German patent application No. 19940831.9 applied in 8/27/1999, the German patent application No. 19940832.7 applied in 27/1999, the German patent application No. 19940833.5 applied in 27/1999, the German patent application No. 19941378.9 applied in 8/31/1999, the German patent application No. 19941379.7 applied in 8/31/1999, the German patent application No. 19941395.9 applied in 8/31/1999, German patent application No. 19942077.7 filed on 9/3/1999, german patent application No. 19942078.5 filed on 9/3/1999, german patent application No. 19942079.3 filed on 9/3/1999, and german patent application No. 19942088.2 filed on 9/3/1999. All of the above-referenced applications are incorporated herein by reference in their entirety.

Background

Certain products and by-products of metabolic processes that occur naturally in cells have utility in a wide variety of industries, including the food industry, feed industry, cosmetic industry, and pharmaceutical industry. These molecules, which are collectively referred to as "fine chemicals", include organic acids, proteinogenic (proteinogenic) and non-proteinogenic amino acids, nucleotides and nucleosides, lipids and fatty acids, diols, sugars, aromatics, vitamins and cofactors, and enzymes. Their production is most conveniently carried out by developing large-scale cultures of bacteria that produce and secrete large quantities of one or more desired molecules. Aparticularly useful organism for this purpose is Corynebacterium glutamicum (Corynebacterium glutamicum), a gram-positive, nonpathogenic bacterium. Through strain selection, a number of mutant strains have been developed that produce a range of desired compounds. However, the selection of improved strains in terms of the production of a particular molecule is a time consuming and difficult process.

Summary of The Invention

The present invention provides novel bacterial nucleic acid molecules having a variety of uses. These include the identification of microorganisms which can be used for the production of fine chemicals, the regulation of the production of fine chemicals in C.glutamicum or related bacteria, the typing or identification of C.glutamicum or related bacteria, as reference points for the mapping of the C.glutamicum genome and as markers for transformation. These novel nucleic acid molecules encode proteins referred to herein as membrane construction and membrane transport (MCT) proteins.

Corynebacterium glutamicum is a gram-positive aerobic bacterium which is commonly used in industry for the large-scale production of a large variety of fine chemicals, also for carbohydrate degradation (e.g.for petroleum spills) and for the oxidation of terpenoids. Thus, the MCT nucleic acid molecules of the invention can be used to identify microorganisms that can be used, for example, to produce fine chemicals by fermentation processes. Modulation of the expression of an MCT nucleic acid according to the invention or modification of the sequence of an MCT nucleic acid molecule according to the invention may be used to modulate the production of one or more fine chemicals from a microorganism (for example to improve the yield or production of one or more fine chemicals from a Corynebacterium or Brevibacterium species).

The MCT nucleic acids of the invention can also be used to identify an organism as corynebacterium glutamicum or a closely related species thereof, or to identify the presence of corynebacterium glutamicum or a related species thereof in a mixed population of microorganisms. The invention provides nucleic acid sequences of various Corynebacterium glutamicum genes; by detecting the extracted genomic DNA of a culture of a specific microorganism or a mixed population of microorganisms under stringent conditions with a probe spanning the gene region of C.glutamicum, one can determine whether this organism is present. Although Corynebacterium glutamicum itself is nonpathogenic, it is associated with pathogenic species in humans, such as Corynebacterium diphtheriae (the causative agent of diphtheria); the detection of such organisms is of great clinical significance.

The MCT nucleic acid molecules of the invention can also be used as reference points for mapping the genome of corynebacterium glutamicum or the genomes of related organisms. Likewise, these molecules or variants or parts thereof can be used as markers for genetically engineered Corynebacterium or Brevibacterium species.

The MCT proteins encoded by the novel nucleic acid molecules of the invention are capable of, for example, performing the function of metabolizing (e.g., biosynthetic or degrading) compounds necessary for participating in membrane biosynthesis or facilitating transport of one or more compounds into or out of a cell across a membrane. It is known that cloning vectors for C.glutamicum, such as those of U.S. Pat. No. 4,649,119 to Sinskey et al, and genetic manipulation techniques for C.glutamicum and related Brevibacterium species, such as Brevibacterium lactofermentum (Yoshihama et al, J.Bacteriol.162: 591-containing 597 (1985); Katsumata et al, J.Bacteriol.159: 306-containing 311 (1984); and Santamaria et al, J.Gen.Microbiol.130: 2237-containing 2246(1984)), are available, and that the nucleic acid molecules of the invention can be used for genetic engineering of such organisms to make them better or more efficient producers of one or more fine chemicals. Such improved production or yield of a fine chemical may be due to a direct effect of manipulation of the gene of the invention or it may be due to an indirect effect of such manipulation.

There are a number of mechanisms by which alterations to the MCT proteins of the invention may directly affect the yield, production or productivity of a fine chemical produced by a strain of C.glutamicum incorporating such altered proteins. Those MCT proteins involved in the export of fine chemical molecules from cells can be increased in number or activity, so that larger amounts of these compounds are secreted into the extracellular medium from which they can be recovered more easily. Likewise, those MCT proteins which are involved in the import of nutrients necessary for the biosynthesis of one or more fine chemicals (e.g.phosphate, sulfate, nitrogenous compounds, etc.) can be increased in number or activity, so that the intracellular concentration of these precursor, cofactor or intermediate compounds is increased. Furthermore, fatty acids and lipids are ideal fine chemicals per se; by optimizing the activity or increasing the amount of one or more MCT proteins of the invention involved in the biosynthesis of these compounds, or by decreasing the activity of one or more MCT proteins involved in the degradation of these compounds, it is possible to increase the yield, production and/or production of fatty acid and lipid molecules by corynebacterium glutamicum.

Mutagenesis of one or more of the MCT genes of the invention may also result in an MCT protein with an altered activity, which indirectly affects the production of one or more desired fine chemicals from C.glutamicum. For example, the MCT proteins of the invention involved in the export of waste products may be increased in quantity or activity such that the normal metabolic wastes of the cell, the quantity of which may be increased due to the overproduction of the desired fine chemical, are efficiently exported before they are able to damage intracellular nucleotides and proteins, which may reduce the viability of the cell, or interfere with the biosynthetic pathway of the fine chemical, which may reduce the yield, production or productivity of the desired fine chemical. In addition, the relatively large intracellular amounts of the desired fine chemical may themselves be toxic to the cell, and it is therefore possible to increase the viability of the cells in culture by increasing the activity or number of transporters which are capable of transporting this compound out of the cell in question, which in turn leads to a larger number of cells in the culture which produce the desired fine chemical. The MCT proteins of the invention can also be manipulated such that relative amounts of different lipid and fatty acid molecules can be produced. This may have a profound effect on the lipid composition of the cell membrane. Since each type of lipid has different physical properties, changes in membrane lipid composition can significantly alter the fluidity of the membrane. Changes in membrane fluidity can affect molecular transport across the membrane and cellular integrity, both of which have profound effects on the production of fine chemicals from C.glutamicum in large-scale fermentation cultures.

The present invention provides novel nucleic acid molecules encoding MCT proteins, herein referred to as MCT proteins, which are capable of participating, for example, in the metabolism of compounds essential for the cell membrane formation of c. Nucleic acid molecules encoding MCT proteins are referred to herein as MCT nucleic acid molecules. In a preferred embodiment, the MCT protein is involved in the metabolism of compoundsessential for the cell membrane formation of c.glutamicum or in the transport of molecules across these membranes. Examples of such proteins include those encoded by the genes described in table 1.

Accordingly, one aspect of the invention relates to an isolated nucleic acid molecule (e.g., cDNA, DNA, or RNA) comprising a nucleotide sequence encoding an MCT protein, or a biologically active portion thereof, and to nucleic acid fragments suitable as primers or hybridization probes for detecting or amplifying MCT-encoding nucleic acids (e.g., DNA or mRNA). In a particularly preferred embodiment, the isolated nucleic acid molecule comprises one of the nucleotide sequences depicted in the odd-numbered SEQ ID NOs of the sequence Listing (e.g., SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7.), or a coding region or the complement thereof of one of these nucleotide sequences. In other particularly preferred embodiments, the isolated nucleic acid molecules of the invention comprise a nucleotide sequence, or portion thereof, that hybridizes to or is at least about 50%, preferably at least about 60%, more preferably at least about 70%, 80% or 90%, even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to a nucleotide sequence set forth as an odd-numbered SEQ ID NO (e.g., SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7.) of the sequence Listing. In other preferred embodiments, the isolated nucleic acid molecule encodes one of the amino acid sequences set forth as even-numbered SEQ ID NOs of the sequence Listing (e.g., SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8.). Preferred MCT proteins of the invention also preferably have at least one MCT activity as described herein.

In another embodiment, the isolated nucleic acid molecule encodes a protein or portion thereof, wherein the protein or portion thereof comprises an amino acid sequence sufficient to be homologous, e.g., sufficient to behomologous, to an amino acid sequence of the present invention (e.g., a sequence having an even-numbered SEQ ID NO in the sequence listing) such that the protein or portion thereof retains MCT activity. Preferably, the protein encoded by the nucleic acid molecule or a part thereof retains the ability to participate in the metabolism of compounds essential for the cell membrane formation of C.glutamicum or in the transport of molecules across these membranes. In one embodiment, the protein encoded by the nucleic acid molecule has at least about 50%, preferably at least about 60%, more preferably at least about 70%, 80% or 90%, most preferably at least about 95%, 96%, 97%, 98% or 99% or more homology to the amino acid sequence of the invention (e.g., the complete amino acid sequence selected from the group consisting of those having even-numbered SEQ ID NOs as in the sequence listing). In another preferred embodiment, the protein is a full length C.glutamicum protein which is substantially homologous to the complete amino acid sequence of the present invention, encoded by the open reading frame shown in the corresponding odd-numbered SEQ ID NO (inverted to SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7.) of the sequence Listing.

In another preferred embodiment, the isolated nucleic acid molecule is derived from Corynebacterium glutamicum and encodes a protein (e.g., an MCT fusion protein) that includes a biologically active domain that is at least about 50% or more homologous to an amino acid sequence of the present invention (e.g., the sequence of an even-numbered SEQ ID NO in the sequence Listing), and is capable of participating in the metabolism of compounds necessary for the cell membrane formation of Corynebacterium glutamicum, or in the transport of molecules across such membranes, or has one or more of the activities described in Table 1, and also includes heterologous nucleic acid sequences encoding heterologous polypeptides or regulatory regions.

In another embodiment, the isolated nucleic acid molecule is at least 15 nucleotides in length and hybridizes under stringent conditions to a nucleic acid molecule comprising a nucleotide sequence of the invention (e.g., a sequence set forth as an odd-numbered SEQ ID NO in the sequence Listing). Preferably, the isolated nucleic acid molecule corresponds to a naturally occurring nucleic acid molecule. More preferably, the isolated nucleic acid encodes a naturally occurring MCT protein from corynebacterium glutamicum, or a biologically active portion thereof.

Another aspect of the invention relates to vectors, e.g.recombinant expression vectors, comprising a nucleic acid molecule of the invention, and to host cells into which such vectors have been introduced. In one embodiment, such a host cell is used to produce MCT protein by culturing the host cell in a suitable medium. The MCT protein is then isolated from the culture medium or the host cell.

Yet another aspect of the present invention relates to a microorganism into which an MCT gene has been introduced or a genetic alteration that alters an MCT gene. In one embodiment, the genome of the microorganism has been altered by introducing as a transgene a nucleic acid molecule of the invention encoding a wild-type or mutant MCT sequence. In another embodiment, the endogenous MCT gene within the genome of the microorganism has been altered, e.g., functionally disrupted, by homologous recombination with the altered MCT gene. In another embodiment, the MCT gene endogenous or introduced in the microorganism is altered by one or more point mutations, deletions, or inversions, but still encodes a functional MCT protein. In yet another embodiment, one or more regulatory regions (e.g., a promoter, a repressor, or an inducer) of an MCT gene in a microorganism have been altered (e.g., by deletion, truncation, inversion, or point mutation) such that expression of theMCT gene is modulated. In a preferred embodiment, the microorganism belongs to the genus Corynebacterium or Brevibacterium, particularly preferably Corynebacterium glutamicum. In a preferred embodiment, the microorganisms are also used for the production of desired compounds, for example amino acids, particularly preferably lysine.

In another aspect, the invention provides a method of identifying the presence or activity of corynebacterium diphtheriae in a subject. The method comprises detecting one or more nucleic acid sequences or amino acid sequences of the invention (e.g., as set forth in SEQ ID NOs 1-676 of the sequence listing) in a subject, thereby detecting the presence or activity of corynebacterium diphtheriae in the subject.

Yet another aspect of the invention relates to an isolated MCT protein, or a portion thereof, e.g., a biologically active portion. In a preferred embodiment, the isolated MCT protein, or portion thereof, may be involved in the metabolism of compounds essential for the cell membrane formation of c.glutamicum or in molecular transport across such membranes. In another preferred embodiment, the isolated MCT protein, or a portion thereof, is sufficiently homologous to the amino acid sequence of the present invention (e.g., the sequence of even-numbered SEQ ID NOs of the sequence listing) such that the protein, or portion thereof, retains the ability to participate in the metabolism of compounds essential for the cell membrane formation of c.glutamicum or in molecular transport across such membranes.

The invention also provides isolated formulations of MCT proteins. In a preferred embodiment, the MCT protein comprises an amino acid sequence of the invention (e.g., a sequence as even-numbered SEQ ID NO in the sequence listing). In another preferred embodiment, the invention relates to an isolated full-length protein substantially homologous to the complete amino acid sequence of the invention (e.g.the sequence of even-numbered SEQ ID NO in the sequence Listing), encoded by the open reading frame indicated by the corresponding odd-numbered SEQ ID NO in sequence Listing A. In yet another embodiment, the protein has at least about 50%, preferably at least about 60%, more preferably at least about 70%, 80% or 90%, most preferably at least about 95%, 96%, 97%, 98% or 99% or more homology to the complete amino acid sequence of the invention (e.g., the sequence of even-numbered SEQ ID NO in the sequence Listing). In other embodiments, the isolated MCT protein comprises an amino acid sequence that is at least about 50% or more homologous to an amino acid sequence of the present invention (e.g., the sequence of even-numbered SEQ ID NOs of the sequence listing), and is capable of participating in the metabolism of compounds essential for cell membrane formation by corynebacterium glutamicum or in molecular transport across such membranes, or has one or more activities described in table 1.

Alternatively, the isolated MCT protein may comprise an amino acid sequence encoded by a nucleotide sequence that hybridizes, e.g., under stringent conditions, to a nucleotide sequence set forth in an even-numbered SEQ ID NO of the sequence Listing, or that is at least about 50%, preferably at least about 60%, more preferably at least about 70%, 80% or 90%, most preferably at least about 95%, 96%, 97%, 98% or 99% or more homologous to a nucleotide sequence set forth in an odd-numbered SEQ ID NO of the sequence Listing. Also preferred are preferred forms of the MCT protein that also possess one or more of the MCT biological activities described herein.

The MCT polypeptide, or biologically active portion thereof, can be operably linked to a non-MCT polypeptide to form a fusion protein. In a preferred embodiment, such fusion proteins have an activity different from the MCT protein alone. In other preferred embodiments, such fusion proteins are involved in the metabolism of compounds essential for the cell membrane formation of C.glutamicum or in the transport of molecules across these membranes. In a particularly preferred embodiment, such fusion proteins are integrated into host cells and modulate the production of a desired compound by said cells.

In another aspect, the invention provides methods for screening for molecules that modulate the activity of an MCT protein, either by interacting with the MCT protein itself or as a substrate or binding partner for the MCT protein, or by modulating transcription or translation of an MCT nucleic acid molecule of the invention, thereby modulating the activity of the MCT protein.

Another aspect of the invention relates to a process for the production of fine chemicals. The method comprises culturing a cell containing a vector that directs the expression of an MCT nucleic acid molecule of the invention such that a fine chemical can be produced. In a preferred embodiment, the method further comprises the step of obtaining a cell comprising such a vector, wherein the cell is transfected with a vector that directs expression of the MCT nucleic acid. In another preferred embodiment, the method further comprises the step of recovering said fine chemical from the culture. In a particularly preferred embodiment, the cells are obtained from the genus Corynebacterium or Brevibacterium, or are selected from those strains described in Table 3.

Another aspect of the invention relates to methods for modulating the production of molecules by microorganisms. Such methods comprise contacting the cell with an agent that modulates MCT protein activity or MCT nucleic acid expression such that a cell-associated activity is altered relative to the activity in the absence of the agent. In a preferred embodiment, the metabolic pathways of one or more membrane components of C.glutamicum of said cell are modulated, or the transport of compounds across these membranes of said cell is modulated, so that the yield or production of a desired fine chemical of this microorganism is improved. The agent that modulates MCT protein activity can be an agent that stimulates MCT protein activity or MCT nucleic acid expression. Examples of factors that stimulate MCT protein activity or MCT nucleic acid expression include small molecules, active MCT proteins, and nucleic acids encoding MCT proteins that have been introduced into the cell. Examples of factors that inhibit MCT activity or expression include small molecules and antisense MCT nucleic acid molecules.

Another aspect of the invention relates to a method of modulating the yield of a desired compound from a cell comprising introducing a wild-type or mutant MCT gene into the cell, either on a separate plasmid or integrated into the genome of the host cell. If integrated into the genome, such integration may be random, or it may occur by homologous recombination, such that the native gene is replaced by the introduced copy, resulting in production of the desired compound from the cell to be regulated. In a preferred embodiment, the yield is increased. In another preferred embodiment, the chemical is a fine chemical. In a particularly preferred embodiment, the fine chemical is an amino acid. In a particularly preferred embodiment, the amino acid is L-lysine. Detailed Description

The present invention provides MCT nucleic acid molecules and MCT protein molecules that are involved in the metabolism of cellular membrane components of c. The molecules of the invention can be used either for directly modulating the production of fine chemicals from microorganisms such as C.glutamicum (for example in which overexpression or optimization of fatty acid biosynthesis proteins has a direct effect on the yield, production and/or productivity of fatty acids from modified C.glutamicum), or canhave an indirect effect, which in any case leads to an increase in the yield, production and/or productivity of the desired compound (for example in which modulation of the cell membrane anabolism leads to a change in the yield, production and/or productivity or cell membrane combination, which in turn can affect the production of one or more fine chemicals). Various aspects of the invention are further described below. I. Fine chemicals

The term "fine chemicals" is well known in the art and includes biologically produced molecules having a variety of applications in various industries, such as, but not limited to, the pharmaceutical, agricultural and cosmetic industries. Such compounds include organic acids such as tartaric acid, itaconic acid, and diaminopimelic acid; proteinogenic and non-proteinogenic amino acids; purine and pyrimidine bases, nucleosides and nucleotides (as described, for example, in Kuninaka, A. (1996) nucleotides and related compounds, as described in Biotechnology, Vol.6, p.561-; lipids, saturated and unsaturated fatty acids (e.g., arachidonic acid); glycols (e.g., propylene glycol and butylene glycol); saccharides (e.g., hyaluronic acid and trehalose); aromatic compounds (e.g., aromatic amines, vanillin, and indigo); vitamins and cofactors (e.g., as described in Ullmann's Encyclopedia of Industrial Chemistry, Vol. A27, "Vitamins", pp. 443-613 (1996) VCH: Weinheim and references therein; and Ong, A.S., Niki, E. and Packer, L. (1995) "Nutrition, Lipids, Health, and Disease" Proceedings of the uneSCO/configuration of Scientific and technical associations in Malaysia, and the Society for Free Research-Asia, held by AONa in Japan, 9.1-3.1994, CS Press, (1995)); an enzyme; polyketides (Cane et al (1998) Science 282: 63-68); and those described in Gutcho (1983) Chemicals by Fermentation, Noyes Data Corporation, ISBN: 0818805086 and all other chemicals of the references therein. The metabolism and the use of certain of these fine chemicalsare described in further detail below. A. Amino acid metabolism and uses

Amino acids comprise the basic building blocks of all proteins and are therefore essential for the normal cellular function of all organisms. The term "amino acid" is well known in the art. There are 20 kinds of amino acids that form proteins, which are used as structural units of proteins in which they are linked by peptide bonds; whereas non-proteinogenic amino acids (hundreds of such amino acids are known) are not normally found in proteins (see Ullmann's Encyclopedia of Industrial Chemistry, Vol. A2, pages 57-97 VCH: Weinheim (1985)). Amino acids may have either the D-or L-optical configuration, although L-amino acids are generally the only type found in naturally occurring proteins. The biosynthetic and degradation pathways for each of the 20 protein-forming amino acids have been well characterized in prokaryotic and eukaryotic cells (see, e.g., Stryer, L. biochemistry, 3 rd edition, page 578-590 (1988)). "essential" amino acids (histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan and valine) are so named because of their complex biosynthesis, which is generally nutritionally required, and are readily converted by simple biosynthetic pathways into the remaining 11 "nonessential" amino acids (alanine, arginine, asparagine, aspartic acid, cysteine, glutamic acid, glutamine, glycine, proline, serine and tyrosine). Higher animals do retain the synthesis of some of these amino acids, but essential amino acids must be supplied from the diet in order for normal protein synthesis to occur.

In addition to their function in protein biosynthesis, these amino acids are interesting chemicals themselves, many of which have found various applications in the food industry, feed industry, chemical industry, cosmetic industry, agriculture and pharmaceutical industry. Lysine is not only an important amino acid for human nutrition, but also for monogastric animals (e.g. poultry and pigs). Glutamic acid is most commonly used as a flavoring additive (monosodium glutamate, MSG) and is widely used in the food industry, as are aspartic acid, phenylalanine, glycine and cysteine. Glycine, L-methionine and tryptophan are all used in the pharmaceutical industry. Glutamine, valine, leucine, isoleucine, histidine, arginine, proline, serine and alanine are valuable in the pharmaceutical and cosmetic industries. Threonine, tryptophan and D/L-methionine are commonly used feed additives. (Leuchtenberger, W. (1996) amino acid-technology production and use, described in Rehm et al (eds.) Biotechnology, Vol.6, Chapter 14a, pp.466-. In addition, these amino acids have been found to be useful as precursors for the synthesis of amino acids and protein synthesis, such as N-acetylcysteine, S-carboxymethyl-L-cysteine, (S) -5-hydroxytryptophan, and the amino acids described in Ullmann' S Encyclopedia of Industrial chemistry, Vol.A 2, pp.57-97, VCH: weinheim, 1985.

The biosynthesis of these natural amino acids in organisms (e.g. bacteria) capable of producing these natural amino acids is well characterized (for a review of bacterial amino acid biosynthesis and regulation thereof, see ubbanger, h.e. (1978) ann.rev.biochem.47: 533 @, 606.) by reductive amidation of the intermediate α -ketoglutarate in the citrate cycle, synthesis of glutamate, subsequent production of glutamine, proline and arginine, respectively, from glutamate the biosynthesis of serine is a three-step process, starting with 3-phosphoglycerate (an intermediate in glycolysis), which, after oxidation, transamination and hydrolysis steps, produces this amino acid cysteine and glycine both from serine, which is produced by condensation of homocysteine and serine, which, after prephenation, is produced by transfer of the side chain β -carbon atom to tetrahydrofolate in a reaction catalyzed by serine transhydroxymethyltransferase, phenylalanine and tyrosine are produced after prephenate synthesis in the last two different steps 9 steps, biosynthesis of phenylalanine and tyrosine from the sugar-serine-threonine precursor in the sugar-serine-threonine-phosphate-pyruvate-fructose-glucose-fructose-glucose-.

Amino acids in the cell's excess protein synthesis requirements cannot be stored, but are degraded, providing intermediates for the cell's major metabolic pathways (for a review see Stryer, L. biochemistry, 3 rd edition, Chapter 21, "amino acid degradation and Urea cycle", pages 495-516 (1988)). Although cells are able to convert unwanted amino acids into useful metabolic intermediates, amino acid production is expensive in terms of energy, precursor molecules, and enzymes necessary for the synthesis of the amino acid. It is therefore not surprising that amino acid biosynthesis is regulated by feedback inhibition, in which the presence of a particular amino acid acts to slow down or completely stop its own production (for a review of the feedback mechanisms in the amino acid biosynthesis pathway, see Stryer, L. biochemistry, 3 rd edition, chapter 24, "biosynthesis of amino acids and heme", page 575-600 (1988)). Thus, the output of any particular amino acid is limited by the amount of amino acids present in the cell. B. Metabolism and use of vitamins, cofactors and nutraceuticals

Vitamins, cofactors and nutrients comprise an additional group of molecules that higher animals have lost their ability to synthesize and therefore must ingest, although they are readily synthesized by other organisms such as bacteria. These molecules are either biologically active substances themselves or precursors of biologically active substances which can be used as electron carriers or intermediates of various metabolic pathways. In addition to their nutritional value, these compounds are also of great industrial value as colorants, antioxidants and catalysts or other processing aids. (for a summary of the structures, activities and Industrial applications of these compounds, see for example Ullman's Encyclopedia of Industrial Chemistry, "Vitamins", volume A27, p. 443-613, VCH: Weinheim, 1996). The term "vitamin" is well known in the art and includes nutrients that are required for normal functioning of an organism but cannot be synthesized by the organism itself. Vitamins may include cofactors and nutraceutical compounds. The term "cofactor" includes non-proteinaceous compounds required for normal enzymatic activity to occur. Such compounds may be organic or inorganic compounds; the cofactor molecules of the present invention are preferably organic molecules. The term "nutraceutical" includes dietary supplements which have health benefits in plants and animals, particularly humans. Examples of such molecules are vitamins, antioxidants and certain lipids (e.g. polyunsaturated fatty acids).

The biosynthesis of these molecules in organisms capable of producing them, such as bacteria, has been characterized in large numbers (Ullman' S Encyclopedia of Industrial Chemistry, "Vitamins", Vol. A27, p. 443, VCH: Weinheim, 1996; Michal, G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley&Sons; Ong, A.S., Niki, E and Packer, L. (1995) "Nutrition, Lipids, Health, and Disease" Proceedings of the Scientific and technical Associations in Malaysia, and the society for Free radiation Research-Research, in Chapter 9, Japan, 1994, Japan).

Production of thiamine (vitamin B) by chemical coupling of pyrimidine and thiazole moieties₁). Riboflavin (vitamin B)₂) Synthesized from guanosine 5 '-triphosphate (GTP) and ribose 5' -phosphate. Riboflavin is in turn used to synthesize Flavin Mononucleotide (FMN) and Flavin Adenine Dinucleotide (FAD). Collectively referred to as "vitamin B₆The family of compounds of (e.g., pyridoxine, pyridoxamine, pyridoxal-5' -phosphate, and pyridoxine hydrochloride used commercially) are derivatives of 5-hydroxy-6-methylpyridine having a common structural unit pantothenic acid ((R) - (+) -N- (2, 4-dihydroxy-3, 3-dimethyl-1-oxobutyl) - β -alanine) can be produced either by chemical synthesis or by fermentation the last step in pantothenic acid biosynthesis consists of ATP-driven condensation of β -alanine and pantoic acid the enzymes responsible for the biosynthetic steps of conversion to pantoic acid, β -alanine and condensation to pantothenic acid are known₅) Production of pantetheine (and its derivatives) and coenzyme a.

The biosynthesis of biotin in microorganisms starting from the precursor molecule pimeloyl-CoA has been studied in detail and several genes involved have been identified A number of corresponding proteins have been found to be involved in the synthesis of the iron cluster as well and are members of the nifS class of proteins lipoic acid is derived from octanoic acid, used as a coenzyme in energy metabolism where it becomes part of the pyruvate dehydrogenase complex and the α -ketoglutarate dehydrogenase complex.

Corrinoids (e.g. cobalamin, in particular vitamin B)₁₂) And porphyrins belong to a class of chemical substances characterized as tetrapyrrole ring systems. Vitamin B₁₂Are sufficiently complex to be incompletely identified, but many of the enzymes and substrates involved are now known. Nicotinic acid and nicotinamide are pyridine derivatives, also known as "nicotinic acid". Nicotinic acid is the precursor of the important coenzymes NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate) and their reduced forms.

The large-scale production of these compounds has been largely dependent on cell-free chemical synthesis, although some of these chemicals have also been produced by large-scale microbial culture, e.g. riboflavin, vitamin B₆Pantothenic acid and biotin. Vitamin B alone₁₂Produced by fermentation due to the complexity of their synthesis. In vitro methods take a lot of raw materials and time, and are usually expensive. C. Metabolism and use of purines, pyrimidines, nucleosides and nucleotides

Purine and pyrimidine metabolic genes and their corresponding proteins are important therapeutic targets for neoplastic diseases and viral infections. The terms "purine" or "pyrimidine" include nitrogenous bases, which are components of nucleic acids, coenzymes and nucleotides. The term "nucleotide" includes the basic building blocks of nucleic acid molecules, which are composed of a nitrogenous base, a pentose sugar (in the case of RNA, the sugar is ribose; in the case of DNA, the sugar is D-deoxyribose), and phosphoric acid. The term "nucleoside" includes molecules that serve as nucleotide precursors but lack the phosphate moiety that a nucleotide possesses. By inhibiting the biosynthesis of these molecules or the transfer of their nucleic acid-forming molecules, it is possible to inhibit the synthesis of RNA and DNA; by inhibiting this activity in a manner that targets cancer cells, the ability of tumor cells to divide and replicate can be inhibited. In addition, there are nucleotides that do not form nucleic acid molecules, but rather serve as energy storage (i.e., AMP) or as coenzymes (i.e., FAD and NAD).

Several publications have described the use of these chemicals for these medical indications by affecting purine and/or pyrimidine metabolism (e.g. Christopherson, R.I. and Lyons, S.D. (1990) "effective inhibitors of pyrimidine and purine de novo biosynthesis as chemotherapeutic agents", Med. Res. reviews 10: 505-. Research on enzymes involved in purine and pyrimidine metabolism has focused on the development of new drugs that can be used, for example, as immunosuppressive or antiproliferative agents (Smitl, J.L., (1995) "enzymes in nucleotide synthesis", Curr. Opin. struct. biol.5: 752-757; (1995) Biochem Soc. Transact.23: 877-902). However, purine and pyrimidine bases, nucleosides and nucleotides have other uses: as intermediates for the biosynthesis of several fine chemicals (e.g.thiamine, S-adenosyl-methionine, folic acid or riboflavin), as energy carriers for cells (e.g.ATP or GTP) and for the chemicals themselves, generally as flavin enhancers (e.g.IMP or GMP) or for several pharmaceutical applications (see e.g.Kuniaka, A. (1996) nucleic acids and Related Compounds in Biotechnology, Vol.6, Rehm et al, VCH: Weinheim, p.561-612). In addition, enzymes involved in purine, pyrimidine, nucleoside or nucleotide metabolism are increasingly used as targets for the development of chemicals for protecting crops, including fungicides, herbicides and insecticides.

The metabolism of these compounds in bacteria has been identified (for reviews see, for example, Zalkin, H. and Dixon, J.E. (1992) "de novo biosynthesis of purine nucleotides", by: Progress in Nucleic Acid Research and Molecular Biology, Vol.42, Academic Press, pp.259-287, and Michal, G. (1999) "nucleotides and nucleosides", by: Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, Chapter 8, Wiley: New York). Purine metabolism has been the subject of extensive research and is essential for the normal function of cells. Impaired purine metabolism in higher animals can cause serious diseases such as gout. Purine nucleotides are synthesized starting from ribose 5-phosphate, which, through a series of steps of intermediate compounds inosine 5 ' -phosphate (IMP), leads to the production of guanosine 5 ' -monophosphate (GMP) or adenosine 5 ' -monophosphate (AMP), from which the triphosphate forms used as nucleotides are readily produced. These compounds are also used as energy stores because their degradation provides energy for many different biochemical processes in the cell. Pyrimidine biosynthesis proceeds via the formation of uridine 5' -monophosphate (UMP) from ribose 5-phosphate. UMP is in turn converted into cytidine-5' -triphosphate (CTP). All of these deoxyforms of nucleotides are produced in a one-step reduction reaction from the ribose diphosphate form of the nucleotide to the deoxyribose diphosphate form of the nucleotide. After phosphorylation, these molecules are able to participate in DNA synthesis. D. Metabolism and use of trehalose

Trehalose consists of two glucose molecules linked in a α -1, 1-linkage trehalose is commonly used as a sweetener in the food industry, i.e. as an additive in dried or frozen foods and beverages, however, it also has many applications in the pharmaceutical, cosmetic and biotechnological industries (see e.g. Nishimoto et al, (1998) U.S. Pat. No.5,759,610; Singer, MA. and Lindquist, S. (1998) Trends Biotech.16: 460. 467; Paiva, C.L.A. and Panek, A.D. (1996) Biotech.Ann.Rev.2: 293. 314; and Shiosaka, M. (1997) J.Japan 172: 97-102.) trehalose is produced with enzymes from a number of microorganisms and is naturally released into the surrounding medium from which trehalose and transport membranes can be collected from transmembrane II. transport membranes using methods known in the art

Cell membranes have a variety of functions in cells. First and foremost, the cell membrane distinguishes the cell contents from the surrounding environment, thus giving the cell integrity. The cell membrane also serves as a barrier to the influx of harmful or unwanted compounds and to the efflux of desired compounds. Cell membranes are naturally impermeable to hydrophilic compounds that do not readily diffuse, such as proteins, water molecules and ions, due to the Structure of their lipid Molecular bilayer in which the polar head faces outward (toward the outside and inside of the cell, respectively) and the tail of the dosage form faces inward toward the center of the bilayer, forming a hydrophobic core (for a general review of membrane Structure and Function, see Gennis, R.B, (1989) biomebranes, Molecular Structure and Function, Springer: Heidelberg). This barrier enables the cells to maintain a relatively higher concentration of the desired compound than contained in the surrounding medium and a relatively low concentration of the undesired compound, since diffusion of these compounds is effectively blocked by the membrane. However, the membrane also provides an effective barrier to input of desired compounds and output of waste molecules. To overcome this difficulty, cell membranes incorporate a number of classes of transporters that can facilitate the transport of different classes of compounds across the membrane. There are two main classes of transporters: porins or channel proteins and transporters. The former forms membrane-internal proteins, sometimes protein complexes, constituting regulated membrane pores that pass through the membrane. This modulation or "gating" is generally specific for the molecules to be transported by the porins or channel proteins, so that these transmembrane constructs are selectively permeable to a particular class of substrates; for example, potassium channels are constructed so that only ions of similar charge and size to potassium can pass through. Channel proteins and porins often have separate hydrophobic and hydrophilic domains such that the hydrophobic side of the protein can associate with the interior of the membrane, while the hydrophilic side lines the interior of the channel, thereby providing a protected hydrophilic environment through which selected hydrophilic molecules can pass. Many such membrane pores/channels are known in the art, including those for potassium, calcium, sodium and chloride ions.

The transport of molecules through this process is sometimes referred to as "facilitated diffusion" because the driving force of the concentration gradient is required for the transport to occur when the concentration of larger molecules (e.g., glucose or other sugars) is higher on one side of the membrane than on the other, permeases also provide facilitated diffusion of these molecules into cells (also referred to as "one-way transport"). in contrast to membrane pores or channels, these integral membrane proteins (typically having 6-14 transmembrane α -helices) do not form open channels through the membrane, but rather bind to target molecules at the membrane surface, and then undergo a conformational change such that the target molecules are released on the opposite side of the membrane.

However, cells often require the import or export of molecules against existing concentration gradients ("active transport"), which is the case where facilitated transport cannot occur. Cells use two main mechanisms for membrane transport: symporter or antiport, and energy-coupled transport, such as ABC transporter-mediated transport. Symporter and antiport systems couple the movement of two different molecules across the membrane (by permeases having two separate binding sites for the two different molecules); in co-transport, two molecules are transported in the same direction, whereas in counter-transport, one molecule is input and the other molecule is output. This is energetically possible because one of the two molecules moves according to a concentration gradient, and this energetically favorable event is only allowed when the inverse dominant (previling) concentration gradient of the desired compound moves simultaneously. In energy-driven processes, a single molecule can be transported across a membrane by a reverse concentration gradient, such as the energy-driven processes utilized by ABC transporters. In this system, the membrane-localized transporter has an ATP-binding cassette; when the target molecule binds, ATP is converted to ADP + Pi and the resulting energy release is used to drive the movement of the transporter-facilitated target molecule to the other side of the membrane. For amore detailed description of all these transport systems, see: bamberg, e, et al, (1993) "charge transport by ion pump on lipid bilayer membrane", q.rev.biophysis.26: 1 to 25; findlay, j.b.c. (1991) "structure and function in membrane transport systems", curr. 804 and 810; higgins, C.F (1992) "ABC transporters from microorganisms to humans", ann.rev.cell biol.8: 67 to 113; gennis, R.B, (1989) "membrane pores, channels and transporters" carried by: biomembrans, Molecular Structure and Function, Springer: heidelberg, pp 270-322; and Nikaido, h. and Saier, h. (1992) "transporters in bacteria: common theme in its design, "Science 258: 936-942 and references contained in each of these references.

The synthesis of membranes is a well characterized process involving a number of components, the most important of which are lipid molecules. Lipid synthesis can be divided into two parts: the synthesis of fatty acids and their attachment to sn-glycerol-3-phosphate, and the addition or modification of polar head groups. Typical lipids used in bacterial cell membranes include phospholipids, glycolipids, sphingolipids and phosphoglycerides. Fatty acid synthesis begins with either conversion of acetyl-CoA to malonyl-CoA by an acetyl-CoA carboxylase or conversion of acetyl-CoA to acetyl-ACP by an acetyl transferase. After the condensation reaction, the two product molecules together form acetoacetyl-ACP, which is converted through a series of condensation, reduction, and dehydration reactions to produce saturated fatty acid molecules having the desired chain length. The production of unsaturated fatty acids from such molecules is catalyzed aerobically, or anaerobically, by specific desaturases either with the aid of molecular oxygen (references on fatty acid synthesis, see F.C. Neidhardt et al (1996) E.coli and Salmonella. ASM Press: Washington, D.C., p.612. 636. and references contained therein; Lenger et al (eds.) (1999) Biology of Carcaryotes. Thieme: Stuttgart, New York and references contained therein; and Magnus, K.et al (1993) Microbiological Reviews 57: 522. 542. and references contained therein). Cyclopropane Fatty Acids (CFAs) are synthesized by specific CFA synthases using SAM as a co-substrate. Branched chain fatty acids are synthesized by deamination of branched chain amino acids to produce branched chain 2-keto-acids (see Lengeler et al (1999) Biology of Procaryotes. Thieme: Stuttgart, New York and references contained therein). Another essential step in lipid synthesis is the transfer of fatty acids to the polar head group by, for example, glycerol-phosphate-acyltransferase. The combination of various precursor molecules and biosynthetic enzymes results in the production of different fatty acid molecules, which has a profound effect on the composition of the membrane. Elements and methods of the invention

The present invention is based, at least in part, on the discovery of novel molecules, referred to herein as MCT nucleic acid and protein molecules, that control the production of cell membranes in corynebacterium glutamicum and that control the movement of molecules across such membranes. In one embodiment, the MCT molecule is involved in the metabolism of compounds essential for the cell membrane formation of c.glutamicum or in the transport of molecules across these membranes. In a preferred embodiment, the MCT molecules of the invention have an effect on the ability of the organism to modulate the production of membrane components and membrane transport. In a particularly preferred embodiment, the MCT molecules of the invention are modulated in activity such that the metabolic pathways of corynebacterium glutamicum modulated by the MCT proteins of the invention are modulated in efficiency, in terms of yield, production and/or yield and transport of compounds through the membrane, are altered, which either directly or indirectly modulate the yield, production and/or yield of a desired fine chemical of corynebacterium glutamicum.

The term "MCT protein" or "MCT polypeptide" includes proteins involved in the metabolism of compounds essential for the cell membrane formation of c.glutamicum or in the transport of molecules across these membranes. Examples of MCT proteins include those encoded by the MCT gene and odd-numbered SEQ ID NOs as described in table 1. The term "MCT gene" or "MCT nucleic acid sequence" includes nucleic acid sequences encoding MCT proteins, consisting of a coding region and corresponding untranslated 5 'and 3' sequence regions. Examples of MCT genes include those described in table 1. The term "yield" or "productivity" is well known in the art and includes the concentration of fermentation product (e.g. desired fine chemical) produced (e.g. kg product per liter per hour) at a given time and in a given fermentation volume. The term "yield" includes the time required for a particular production level to be achieved (e.g.how long it takes for a cell to reach a particular fine chemical production rate). The terms "yield" or "product/carbon yield" are well known in the art and include the efficiency of the conversion of the carbon source into the product (i.e.the fine chemical). This is usually expressed, for example, as kg product per kg carbon source. By increasing the yield or production of the compound, the amount of recovered or available recovered molecules of the compound in a given amount of culture at a given time is increased. The term "biosynthesis" or "biosynthetic pathway" is well known in the art and includes the synthesis of compounds, preferably organic compounds, by a cell starting from intermediate compounds in a process which can be multistep and highly regulated. The term "degradation" or "degradation pathway" is well known in the art and includes the breakdown of compounds, preferably organic compounds, into degradation products (generally, smaller or less complex molecules) by cells in a process that can be multi-step and highly regulated. Theterm "metabolism" is well known in the art and includes all biochemical reactions occurring in an organism. The metabolism of a particular compound (e.g., the metabolism of an amino acid such as glycine) then includes all biosynthetic, modification, and degradation pathways in the cell that are associated with the compound.

In another embodiment, the MCT molecules of the invention are capable of modulating the production of a desired molecule, such as a fine chemical, in a microorganism, such as C.glutamicum. There are a number of mechanisms by which alterations to the MCT proteins of the invention may directly affect the yield, production and/or production of a fine chemical from a strain of C.glutamicum incorporating such altered proteins. Those MCT proteins involved in the export of fine chemicals from cells can be increased in number or activity, so that larger amounts of these compounds are secreted into the extracellular medium from which they can be more easily recovered. Likewise, those MCT proteins which are involved in the nutrient input necessary for the biosynthesis of one or more fine chemicals (e.g.phosphate, sulfate, nitrogenous compounds, etc.) can be increased in number or activity, so that the concentration of these precursor, cofactor or intermediate compounds in the cell is increased. Furthermore, fatty acids and lipids are ideal fine chemicals per se; it is possible to increase the yield, production and/or production of fatty acid or lipid molecules from corynebacterium glutamicum by optimizing the activity of one or more MCT proteins of the invention involved in the biosynthesis of these compounds, or increasing the amount of said MCT proteins, or by decreasing the activity of one or more MCT proteins involved in the degradation of these compounds.

Mutagenesis of one or more MCT genes of the invention may also result in MCT proteins with altered activity, which indirectly affect the production of oneor more desired fine chemicals from C.glutamicum. For example, the MCT proteins of the invention involved in the export of waste products may be increased in number or activity such that the normal metabolic waste products of the cell, which may be increased in amount due to the overproduction of the desired fine chemical, are efficiently exported before being able to damage the intracellular nucleotides and proteins, which may reduce the viability of the cell, or to interfere with the biosynthesis pathway of the fine chemical, which may reduce the yield, production or production of the desired fine chemical. Furthermore, the relatively large intracellular amounts of the desired fine chemical may themselves be toxic to the cell, and it is therefore possible, by increasing the activity or number of transporters which are capable of transporting the compound out of the cell, to increase the viability of the cells in culture and thus to generate larger amounts of cells in culture which produce the desired fine chemical. The MCT proteins of the invention can also be manipulated so that relative amounts of different lipid and fatty acid molecules are produced. This may have a profound effect on the lipid composition of cell membranes. Since each type of lipid has different physical properties, changes in membrane lipid composition can significantly alter the fluidity of the membrane. Changes in membrane fluidity may affect the transport of molecules across the membrane and the integrity of the cells, both of which have profound effects on the production of fine chemicals from C.glutamicum in large-scale fermentation cultures.

The isolated nucleic acid sequences of the present invention are contained in the genome of a strain of Corynebacterium glutamicum available from the American type culture Collection under accession number ATCC 13032. The nucleotide sequence of the isolated corynebacterium glutamicum MCT DNA and the predicted amino acid sequence of the corynebacterium glutamicumMCT protein are shown in odd-numbered SEQ ID NOs and even-numbered SEQ ID NOs in the sequence listing, respectively. Computational analysis is performed to classify and/or identify these nucleotide sequences as coding sequences for proteins involved in the metabolism of cellular membrane components or in the transport of compounds across these membranes.

The invention also relates to proteins having amino acids substantially homologous to the amino acid sequences of the invention (e.g., the sequences of even-numbered SEQ ID NOs of the sequence Listing). As used herein, a protein having an amino acid sequence that is substantially homologous to a selected amino acid sequence is at least about 50% homologous to the selected amino acid sequence (e.g., the entire selected amino acid sequence). Proteins having an amino acid sequence that is substantially homologous to a selected amino acid sequence may also have at least about 50-60%, preferably at least about 60-70%, more preferably at least about 70-80%, 80-90% or 90-95%, and most preferably at least about 96%, 97%, 98%, 99% or more homology to the selected amino acid sequence.

The MCT proteins of the invention, or biologically active portions or fragments thereof, can be involved in the metabolism of compounds essential for the cell membrane formation of c.glutamicum or in the molecular transport across these membranes, or have one or more of the activities described in table 1.

Various aspects of the invention are described in more detail in the following subsections. A. Isolated nucleic acid molecules

One aspect of the invention relates to isolated nucleic acid molecules encoding MCT polypeptides, or biologically active portions thereof, and nucleic acid fragments sufficient for use as hybridization probes or primers for the identification or amplification of MCT-encoding nucleic acids (e.g., MCT DNA). Theterm "nucleic acid molecule" as used herein will be meant to include both DNA molecules (e.g., cDNA or genomic DNA) and RNA molecules (e.g., mRNA) as well as analogs of the DNA or RNA generated using nucleotide analogs. The term also includes untranslated sequences located 3 'and 5' to the coding region of a gene: a sequence of at least about 100 nucleotides upstream of the 5 'end of the coding region of the gene and a sequence of at least about 20 nucleotides downstream of the 3' end of the coding region. The nucleic acid molecule may be single-stranded or double-stranded, but is preferably double-stranded DNA. An "isolated" nucleic acid molecule is one that is separated from other nucleic acid molecules that are present in the natural source of the nucleic acid. Preferably, an "isolated" nucleic acid is free of sequences naturally adjacent to the nucleic acid (i.e., sequences located at the 5 'and 3' ends of the nucleic acid) in the genomic DNA of the organism from which the nucleic acid is derived. For example, in various embodiments, an isolated MCT nucleic acid molecule can contain less than about 5kb, 4kb, 3kb, 2kb, 1kb, 0.5kb, or 0.1kb of nucleotide sequences that naturally border the nucleic acid molecule in the genomic DNA of the cell from which the nucleic acid is derived (e.g., a corynebacterium glutamicum cell). In addition, an "isolated" nucleic acid molecule, such as a DNA molecule, may be substantially free of other cellular material, or free of culture medium when produced by recombinant techniques, or free of chemical precursors or other chemicals when chemically synthesized.

Nucleic acid molecules of the invention, e.g., having the nucleotide sequence set forth as an odd-numbered SEQ ID NO in the sequence Listing, or portions thereof, can be isolated using standard molecular biology techniques and the sequence information provided herein. For example, a Corynebacterium glutamicum MCT DNA may be isolated from a Corynebacterium glutamicumlibrary using standard hybridization techniques (e.g., the techniques described in Sambrook, J., Fritsh, E.F. and Maniatis, T.molecular cloning: A Laboratory Manual, 2 nd edition, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989) using all or part of one of the odd-numbered SEQ ID NO sequences of the sequence Listing as hybridization probes. Furthermore, a nucleic acid molecule comprising all or part of one of the nucleic acid sequences of the invention (e.g. an odd-numbered SEQ ID NO) can be isolated by polymerase chain reaction using an oligonucleotide primer designed on the basis of this sequence (e.g. a nucleic acid molecule comprising all or part of one of the nucleic acid sequences of the invention (e.g. an odd-numbered SEQ ID NO) of the sequence listing can be isolated by polymerase chain reaction using an oligonucleotide primer designed on the basis of said sequence). For example, mRNA can be isolated from normal endothelial cells (e.g., by the guanidinium isothiocyanate extraction method of Chirgwin et al (1979) Biochemistry 18: 5294-. Synthetic oligonucleotide primers for polymerase chain reaction amplification can be designed based on one of the nucleotide sequences shown in the sequence listing. The nucleic acids of the invention may be amplified using cDNA or genomic DNA as a template, using appropriate oligonucleotide primers, according to standard PCR amplification techniques. The nucleic acid thus amplified is cloned into a suitable vector and identified by DNA sequence analysis. Furthermore, oligonucleotides corresponding to MCT nucleotide sequences can be prepared by standard synthetic techniques, for example, using an automated DNA synthesizer.

In a preferred embodiment, the isolated nucleic acid molecule of the invention comprises a nucleotide sequence as set forth in the sequence listing. The nucleic acid sequence of the invention shown in the sequence listing corresponds to the MCT DNA of Corynebacterium glutamicum of the invention. The DNAcomprises a sequence encoding MCT protein (i.e. "coding region" shown in odd-numbered SEQ ID NOs of the sequence Listing, respectively) and 5 'untranslated sequences and 3' untranslated sequences, which are also shown in odd-numbered SEQ ID NOs of the sequence Listing, respectively. In another aspect, the nucleic acid molecule may comprise only the coding region of any of the nucleic acid sequences in the sequence listing.

For such applications, it will be understood that each of the nucleic acid and amino acid sequences shown in the sequence listing has an identifying RXA, RXN, RXS or RXC number with the identifier "RXA", "RXN", "RXS" or "RXC" followed by a5 digit number (i.e., RXA02099, RXN03097, RXS00148 or RXC 01748). Each of said nucleic acid sequences comprises at most three portions: a 5' upstream region, a coding region and a downstream region. Each of these three zones is identified by the same RXA, RXN, RXS or RXC identifier to avoid confusion. The recitation "one of the odd-numbered sequences in the sequence listing" refers to any nucleic acid sequence in the sequence listing, which may also be distinguished according to its different RXA, RXN, RXS or RXC identifier. The coding region of each of these sequences is translated into the corresponding amino acid sequence, which is also shown in the sequence listing as an even-numbered SEQ ID NO immediately following the corresponding nucleic acid sequence. For example, the coding region of RXA03097 is shown in SEQ ID NO: 1 and the amino acid sequence encoded thereby is shown in SEQ ID NO: 2 in (c). The sequences of the nucleic acid molecules of the invention are identified by the same RXA, RXN, RXS or RXC identifier as the amino acid molecule they encode, so that they can be readily associated. For example, the amino acid sequences named RXA02099, RXN03097, RXS00148, and RXC01748 are translations of the coding regions of the nucleotide sequences of nucleic acid molecules RXA02099, RXN03097, RXS00148, and RXC01748, respectively. The correspondence between the nucleotide and amino acid sequences of RXA, RXN, RXS and RXC of the present invention and their designated SEQ ID NO is shown in table 1. For example, as shown in table 1, the nucleotide sequence of RXA00104 is SEQ ID NO: 5, and the amino acid sequence of RXA00104 is SEQ ID NO: 6.

several genes of the present invention are "F-tagged genes". The genes identified by F include those shown in Table 1 having an "F" preceding an identifier of RXA, RXN, RXS or RXC. For example, SEQ ID NO: 11 is an F-tagged gene, SEQ ID NO: 31. 33, and 43 (designated "F RXA 02487", "F RXA 02490", "F RXA 02809", respectively, in table 1).

In one embodiment, the nucleic acid molecules of the invention are not meant to include those compiled in table 2. For the dapD gene, the sequence of the gene is published in Wehrmann, A.et al (1998) J.Bacteriol.180 (12): 3159 and 3165. However, the sequences obtained by the inventors of the present application are significantly longer than the published forms. The published format is believed to rely on an incorrect start codon and therefore represents only a fragment of the authentic coding region.

In another preferred embodiment, an isolated nucleic acid molecule of the invention comprises a nucleic acid molecule or a portion thereof which is the complement of one of the nucleotide sequences of the invention (e.g., the odd-numbered SEQ ID NO sequences in the sequence listing). A nucleic acid molecule which is a complementary sequence to one of the nucleotide sequences shown in the present invention is a nucleic acid molecule which is sufficiently complementary to one of the nucleotide sequences shown in the sequence listing (e.g. the odd-numbered SEQ ID NO sequences) so that it can hybridize to one of the nucleotide sequences of the present invention and thus form a stable duplex.

Inyet another preferred embodiment, an isolated nucleic acid molecule of the invention comprises a nucleotide sequence having at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60% homology to a nucleotide sequence of the invention (e.g., the sequence set forth as an odd-numbered SEQ ID NO in the sequence listing), preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, even more preferably at least about 95%, 96%, 97%, 98%, 99% or more, or a portion thereof. The invention also includes ranges between the above values and the identifying values (e.g., 70-90% identical or 80-95% identical). For example, ranges of identification values that include any combination of the above values as upper and/or lower limits are intended to be included. In another preferred embodiment, an isolated nucleic acid molecule of the invention comprises a nucleotide sequence or a part thereof which hybridizes with one of the nucleotide sequences of the invention, e.g. under stringent conditions.

Furthermore, the nucleic acid molecules of the invention may comprise only a part of the coding region of an odd-numbered SEQ ID NO sequence of the sequence Listing, for example a fragment which can be used as a probe or primer or a fragment which encodes a biologically active portion of an MCT protein. The nucleotide sequence determined by cloning the MCT gene from C.glutamicum allows the generation of probes and primers designed for the identification and/or cloning of MCT homologues in other cell types and organisms, as well as MCT homologues from other coryneform bacteria or related species. The probes/primers typically comprise substantially purified oligonucleotides. The oligonucleotide typically comprises a nucleotide sequence region which hybridizes under stringent conditions to at least about 12, preferably about 25, more preferably about 40, 50 or 75 consecutive nucleotides of a sense strand of one of the nucleotide sequences of the invention (e.g., an odd-numbered SEQ ID NO sequence of the sequence listing), an antisense sequence of one of these sequences, or a naturally occurring mutant thereof. Primers based on the nucleotide sequences of the present invention can be used in PCR reactions to clone MCT homologs. Probes based on the MCT nucleotide sequence can be used to detect transcripts or genomic sequences encoding the same protein or homologous proteins. In preferred embodiments, the probe further comprises a labeling group attached thereto, e.g., the labeling group can be a radioisotope, a fluorescent compound, an enzyme, or an enzyme cofactor. Such probes can be used as part of a diagnostic test kit to identify cells that erroneously express (miscompressed) MCT protein, e.g., by determining the level of MCT-encoding nucleic acid in a sample of cells, e.g., detecting MCT mRNA levels or detecting whether a genomic MCT gene has been mutated or deleted.

In one embodiment, the nucleic acid molecule of the invention encodes a protein or a part thereof comprising an amino acid sequence sufficiently homologous to the amino acid sequence of the invention (e.g.the sequence of even-numbered SEQ ID NO in the sequence Listing) such that the protein or part thereof retains the ability to participate in the metabolism of compounds essential for the cell membrane formation of C.glutamicum or in the transport of molecules across these membranes. The term "sufficiently homologous", as used herein, refers to a protein or a part thereof having an amino acid sequence comprising a minimum number of amino acid residues identical or equivalent to the amino acid sequence of the present invention (e.g. having a side chain similar to an amino acid residue in an even-numbered SEQ ID NO sequence of the sequence listing) such that said protein or part thereof is capable of participating in the metabolism of compounds essential for the cell membrane formation of c. Protein members of such membrane component metabolic pathways or membrane transport systems as described herein may play a role in the production and secretion of one or more fine chemicals. Examples of such activities are also described herein. Thus, the "function of an MCT protein" affects, either directly or indirectly, the yield, production and/or productivity of the production of one or more fine chemicals. Examples of MCT protein activity are shown in table 1.

In another embodiment, the protein has at least about 50-60%, preferably at least about 60-70%, more preferably at least about 70-80%, 80-90%, 90-95%, and most preferably at least about 96%, 97%, 98%, 99% or more homology to the complete amino acid sequence of the present invention (e.g., the sequence set forth as even-numbered SEQ ID NO sequences of the sequence Listing).

The portion of the protein encoded by the MCT nucleic acid molecules of the invention is preferably a biologically active portion of the MCT protein. The term "biologically active portion of an MCT protein" as used herein is intended to include a portion of an MCT protein, e.g., a domain/motif, or having one of the activities described in table 1, that may be involved in the metabolism of compounds essential for the cell membrane formation of c. To determine whether an MCT protein, or a biologically active portion thereof, can be involved in the metabolism of compounds essential for the cell membrane formation of c.glutamicum or in the transport of molecules across these membranes, an assay for enzymatic activity can be performed. Such assays are well known to those skilled in the art, as described in detail in example 8 of the examples section.

Additional nucleic acid fragments encoding biologically active portions of MCT proteins can be prepared by isolating a portion ofan amino acid sequence of the invention (e.g., the even-numbered SEQ ID NO sequence of the sequence listing), expressing a portion of the encoded MCT protein or peptide (e.g., by in vitro recombinant expression), and evaluating the activity of the encoded MCT protein or peptide portion.

The invention also includes nucleic acid molecules that differ from one of the nucleotide sequences of the invention (e.g., the odd-numbered SEQ ID NO sequences in the sequence listing) (and portions thereof) due to the degeneracy of the genetic code and thus encode an MCT protein identical to the protein encoded by the nucleotide sequence of the invention. In another embodiment, the isolated nucleic acid molecule of the invention has a nucleotide sequence encoding a protein having an amino acid sequence as set forth in the sequence listing (e.g., even-numbered SEQ ID NO). In a further embodiment, the nucleic acid molecule of the invention encodes a full-length corynebacterium glutamicum protein which is substantially homologous to the amino acid sequence of the invention (encoded by the open reading frame shown in the odd-numbered SEQ ID NOs of the sequence listing).

It will be understood by those skilled in the art that in one embodiment, the sequences of the present invention are not meant to include prior art sequences, such as those of the Genbank sequences obtained prior to the present invention as set forth in tables 2 or 4. In one embodiment, the invention includes nucleotide sequences and amino acid sequences that have a percent identity with a nucleotide sequence or amino acid sequence of the invention that is greater than the percent identity of prior art sequences, such as the Genbank sequences (or proteins encoded by such sequences) recited in tables 2 or 4. For example, the present invention includes: a nucleotide sequence having more than 38% identity and/or at least 38% identity to the nucleotide sequence named RXA01420(SEQID NO: 7); a nucleotide sequence having greater than 41% identity and/or at least 41% identity to the nucleotide sequence named RXA00104(SEQ ID NO: 5); and a nucleotide sequence having more than 45% identity and/or at least 45% identity to the nucleotide sequence named RXA02173(SEQ ID NO: 25). One skilled in the art can calculate the lower limit for the given percent sequence identity of the invention by examining the percent identity scores calculated for the GAPs shown in table 4 for each of the three highest hits in any given sequence of the invention and subtracting the highest percent identity score calculated for GAP from 100%. One skilled in the art will also recognize that the invention also includes nucleic acid sequences and amino acid sequences having a percent identity greater than the lower limit so calculated (e.g., at least 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, even more preferably at least about 95%, 96%, 97%, 98%, 99%, or more).

In addition to the MCT nucleotides of corynebacterium glutamicum shown in odd-numbered SEQ ID NOs of the sequence listing, one skilled in the art will recognize that DNA sequence polymorphisms may exist in a population (e.g., a population of corynebacterium glutamicum) that result in alterations in the amino acid sequence of the MCT protein. Such genetic polymorphisms in the MCT gene may be present in individuals of a population due to natural variation. The terms "gene" and "recombinant gene" as used herein refer to a nucleic acid molecule comprising an open reading frame encoding an MCT protein, preferably an MCT protein from corynebacterium glutamicum. Such natural variations can typically result in 1-5% variation in the nucleotide sequence of the MCT gene. Any and all such nucleotide variations and resulting amino acid polymorphisms in MCT that are the result of natural variation and that do not alter the functional activity of the MCT protein are intended to be within the scope of the present invention.

Nucleic acid molecules corresponding to natural variants of the corynebacterium glutamicum MCT DNA and non-corynebacterium glutamicum homologs of the present invention can be isolated based on their homology to the corynebacterium glutamicum MCT nucleic acids disclosed herein, using the corynebacterium glutamicum DNA, or portions thereof, as a hybridization probe under stringent hybridization conditions according to standard hybridization techniques. Thus, in another embodiment, an isolated nucleic acid molecule of the invention is at least 15 nucleotides in length and hybridizes under stringent conditions to a nucleic acid molecule comprising the nucleotide sequence of an odd-numbered SEQ ID NO of the sequence listing. In other embodiments, the nucleic acid is at least 30, 50, 100, 250 or more nucleotides in length. The term "hybridizes under stringent conditions" as used herein is intended to describe hybridization and washing conditions under which nucleotide sequences at least 60% homologous to each other typically remain hybridized to each other. Preferably, the conditions are such that sequences that are at least about 65%, more preferably at least about 70%, even more preferably at least about 75% or more homologous to each other generally remain hybridized to each other. Such stringent conditions are known to those skilled in the art and can be found in Current protocols in Molecular Biology, John Wiley&Sons, N.Y. (1989), 6.3.1-6.3.6. A preferred non-limiting example of stringent hybridization conditions is hybridization in 6 XSSC/sodium citrate (SSC) at about 45 ℃ followed by one or more washes in 0.2 XSSC, 0.1% SDS at 50-65 ℃. Preferably, an isolated nucleic acid molecule of the invention that hybridizes under stringent conditions to a nucleotide sequence of the invention corresponds to a naturally occurring nucleic acid molecule. As used herein, a "naturally-occurring" nucleic acid molecule refers to an RNA or DNA molecule having a naturally-occurring nucleotide sequence (e.g., encoding a native protein). In one embodiment, the nucleic acid encodes a native corynebacterium glutamicum MCT protein.

In addition to naturally occurring variations of the MCT sequence that may be present in a population, those skilled in the art will also recognize that alterations may be introduced by making mutations in the nucleotide sequences of the present invention, thereby resulting in alterations in the amino acid sequence of the encoded MCT protein, without altering the functional capabilities of the MCT protein. For example, nucleotide substitutions that result in amino acid substitutions at "non-essential" amino acid residues may be made in the nucleotides of the invention. A "non-essential" amino acid residue is a residue that can be altered in the wild-type sequence of one of the MCT proteins (e.g., even-numbered SEQ ID NOs of the sequence listing) without altering the activity of the MCT protein, while an "essential" amino acid residue is required for the activity of the MCT protein. However, other amino acid residues (e.g., those residues that are not conserved or only semi-conserved in the domain having MCT activity) may not be essential for activity, and thus may be suitable for alteration without altering MCT activity.

Thus, another aspect of the invention relates to nucleic acid molecules encoding MCT proteins that contain alterations in amino acid residues that are not essential for MCT activity. Such MCT proteins differ in amino acid sequence from the sequence of even-numbered SEQ ID NOs of the sequence listing, but retain at least one MCT activity as described herein. In one embodiment, the isolated nucleic acid molecule comprisesa nucleotide sequence encoding a protein, wherein the protein comprises an amino acid sequence that is at least about 50% homologous to the amino acid sequence of the present invention and is capable of participating in the metabolism of compounds essential for the cell membrane formation of C.glutamicum or in the transport of molecules across these membranes, or has one or more of the activities described in Table 1. Preferably, the nucleic acid molecule encodes a protein that is at least about 50-60% homologous to an amino acid sequence set forth as an odd-numbered SEQ ID NO of the sequence Listing, more preferably at least about 60-70% homologous to one of these sequences, even more preferably at least about 70-80%, 80-90%, 90-95% homologous to one of these sequences, and most preferably at least about 96%, 97%, 98%, or 99% homologous to an amino acid sequence of the present invention.

To determine the percent homology of two amino acid sequences (e.g., one of the amino acid sequences of the invention and a mutant form thereof) or two nucleic acids, the sequences are aligned for optimal comparison (e.g., gaps can be introduced in the sequence of one protein or nucleic acid for optimal sequence alignment with another protein or nucleic acid). The amino acid residues or nucleotides at corresponding amino acid positions or nucleotide positions are then compared. When a position in one sequence (e.g., an amino acid sequence of the invention) is occupied by the same amino acid residue or nucleotide as the corresponding position in another sequence (e.g., a mutant form of the amino acid sequence), then the two molecules are homologous at that position (i.e., amino acid or nucleic acid "homology" as used herein is equivalent to amino acid or nucleic acid "identity"). The percentage homology between these two sequences varies with the number of identical positions shared by the sequences (i.e. percentage homology-number of identical positions/total number of positions x 100).

An isolated nucleic acid molecule encoding an MCT protein homologous to a protein sequence of the present invention (e.g., the even-numbered SEQ ID NO sequence in the sequence listing) can be constructed by introducing one or more nucleotide substitutions, additions or deletions into the nucleotide sequence of the present invention such that one or more amino acid substitutions, additions or deletions are introduced into the encoded protein, the mutations can be introduced into a nucleotide sequence of the present invention using standard techniques, such as site-directed mutagenesis and PCR-mediated mutagenesis.

In addition to the above-described nucleic acid molecules encoding MCT proteins, another aspect of the invention relates to isolated nucleic acid molecules that are antisense. An "antisense" nucleic acid includes a nucleotide sequence that is complementary to a "sense" nucleic acid encoding a protein, e.g., a nucleotide sequence that is complementary to the coding strand of a double-stranded DNA molecule or complementary to an mRNA sequence. Thus, the antisense nucleic acid can form a hydrogen bond with the sense nucleic acid. The antisense nucleic acid is complementary to the entire MCT coding strand or only a portion thereof. In one embodiment, the antisense nucleic acid molecule is an antisense nucleic acid molecule to the "coding region" of the coding strand of the nucleotide sequence encoding the MCT protein. The term "coding region" refers to a region of a nucleotide sequence that includes codons translated into amino acid residues (e.g., the entire coding region of SEQ ID NO: 5(RXA00104) includes nucleotides 1-756). In another embodiment, the antisense nucleic acid molecule is an antisense nucleic acid molecule encoding the "non-coding region" of the nucleotide sequence coding strand of the MCT. The term "non-coding region" refers to 5 'and 3' sequences (i.e., also referred to as 5 'and 3' untranslated regions) that are contiguous with the coding region and that are not translated into amino acids.

Given the coding strand sequence encoding MCT disclosed herein (e.g., the sequence shown in the odd-numbered SEQ ID NO of the sequence Listing), antisense nucleic acids of the present invention can be designed according to the Watton and Crick base pairing rules, the antisense nucleic acid molecule can be complementary to the entire coding region of MCT mRNA, but is more preferably an oligonucleotide that is an antisense molecule that is only part of the coding region or the noncoding region of MCT mRNA. for example, the antisense oligonucleotide can be complementary to a region surrounding the translation initiation site of MCT mRNA. the antisense oligonucleotide can be, for example, about 5, 10, 15, 20, 25, 30, 35, 40, 45, or 50 nucleotides in length. the antisense nucleic acids of the present invention can be constructed using chemical synthesis and enzymatic ligation using methods known in the art. for example, naturally occurring nucleotides or nucleotides can be designed to increase the biological stability of the molecule or to increase the physical stability formed between the antisense nucleic acids and the sense nucleic acids, chemically synthesized antisense nucleic acids (e.g., antisense oligonucleotides) can be further modified with naturally occurring nucleotides or with oligonucleotides designed to increase the biological stability of the antisense nucleic acids of the molecules or to produce antisense nucleic acids with the biological stability of the antisense nucleic acids expressed in the biological directions of N-carboxymethylguanine-2-adenine-2, N-adenine-2, N-adenine-phospho, N-adenine-phospho-2, N-adenine-5, phospho-adenine-2-adenine-5, phospho-adenine-2, phospho-adenine-2-adenine-phospho-adenine, phospho-adenine-5, phospho-adenine-2, phospho-adenine-5, phospho-adenine-2, phospho-adenine-5, phospho-adenine-2, and phospho-adenine-5, and phospho-adenine-phospho-adenine-phospho-5, and the following, or-adenine-phospho-adenine-2-adenine-phospho-adenine-2-adenine-5.

The antisense nucleic acid molecules of the invention are typically administered to cells or produced in situ such that they hybridize or bind to cellular mRNA and/or genomic DNA encoding an MCT protein to thereby inhibit expression of the protein, e.g., by inhibiting transcription and/or translation. Hybridization can be by means of conventional nucleotide complementarity to form a stable duplex, or, for example, in the case of antisense nucleic acid molecules which bind to DNA duplexes, by specific interactions in the major groove of the double helix. The antisense molecule can be modified such that it specifically binds to a selected cell surface expressed receptor or antigen, for example, by linking the antisense nucleic acid molecule to a peptide or antibody that binds to a cell surface receptor or antigen. The antisense nucleic acid molecules can also be delivered to cells using vectors described herein. In order to obtain sufficient intracellular concentrations of the antisense molecules, vector constructs are preferred in which the antisense nucleic acid molecule is placed under the control of a strong prokaryotic, viral or eukaryotic promoter.

In yet another embodiment, the antisense Nucleic acid molecule of the invention is an α -anomeric Nucleic acid molecule α -anomeric Nucleic acid molecule forms specific double-stranded hybrids with complementary RNA in which the strands are complementary in parallel as opposed to the usual β units (Gaultier et al (1987) Nucleic Acids. Res. 15: 6625-6641.) the antisense Nucleic acid molecule may also comprise 2' -o-methylribonucleotides (Inoue et al (1987) Nucleic Acids Res. 15: 6131-6148) or chimeric RNA-DNA analogs (Inoue et al (1987) FEBS Lett.215: 327-330).

In yet another embodiment, the antisense nucleic acid of the invention is a ribozyme. Ribozymes are catalytic RNA molecules with ribonuclease activity that are capable of cleaving a single-stranded nucleic acid, such as an mRNA, with which they have a complementary region. Thus, ribozymes (e.g., hammerhead ribozymes (described in Haselhoff and Gerlach (1988) Nature 334: 585-591)) can be used to catalytically cleave MCT mRNA transcripts, thereby inhibiting translation of MCT mRNA A ribozyme specific for MCT-encoding nucleic acids can be designed based on the nucleotide sequence of the MCT DNA molecules disclosed herein (i.e., SEQ ID NO.5(RXA 00104). for example, a derivative of Tetrahymena (Tetrahymena) L-19 IVS RNA can be constructed in which the nucleotide sequence of the active site is complementary to the nucleotide sequence to be cleaved in MCT-encoding mRNA. see, e.g., U.S. Pat. Nos. 4,987,071 to Cech et al and 5,116,742 to Cech et al or MCT mRNA can be used to select catalytic RNA having specific ribonuclease activity from a pool of RNA molecules-see, e.g., Bartel, D. and Szostak, J.W (1993) Science 261: 1-1418.

On the other hand, expression of the MCT gene can be inhibited by targeting a nucleotide sequence that is complementary to a regulatory region of the MCT nucleotide sequence (e.g., the MCT promoter and/or enhancer) to form a triple helix structure that prevents transcription of the MCT gene in the target cell. See generally Helene, c. (1991) Anticancer Drug des.6 (6): 569-84; helene, C.et al (1992) Ann.N.Y.Acad.Sci.660: 27-36; and Maher, L.J, (1992) Bioassays 14 (12): 807-15. B. Recombinant expression vectors and host cells

Another aspect of the invention relates to vectors, preferably expression vectors, comprising nucleic acids encoding MCT proteins (or portions thereof). The term "vector" as used herein refers to a nucleic acid molecule capable of transporting another nucleic acid to which it is linked. One type of vector is a "plasmid," which refers to a circular double-stranded DNA loop into which additional DNA segments can be ligated. Another type of vector is a viral vector, wherein additional DNA segments can be ligated into the viral genome. Certain vectors are capable of autonomous replication in a host cell into which they are introduced (e.g., bacterial vectors having a bacterial origin of replication and episomal mammalian vectors). Other vectors (e.g., non-episomal mammalian vectors) are integrated into the genome of a host cell upon introduction into the host cell, and thereby are replicated along with the host genome. In addition, certain vectors are capable of directing the expression of genes to which they are operatively linked. Such vectors are referred to herein as "expression vectors". In general, expression vectors of utility in recombinant DNA techniques are typically vectors in the form of plasmids. In the present specification, "plasmid" and "vector" may be used interchangeably, as the plasmid is the most commonly used form of vector. However, the invention is intended to include such other forms of expression vectors, such as viral vectors (e.g., replication defective retroviruses, adenoviruses and adeno-associated viruses), which serve equivalent functions.

The recombinant expression vectors of the invention comprise a nucleic acid of the invention in a form suitable for expression of the nucleic acid of the invention in a host cell, by which is meant that the recombinant expression vector comprises one or more regulatory sequences selected with respect to the host cell used for expression, which regulatory sequences are operably linked to the nucleic acid sequence to be expressed. In a recombinant expression vector, "operably linked" means that the vector will be susceptible toThe nucleotide sequence of interest is linked to the regulatory sequence in a manner which allows expression of the nucleotide sequence, for example in an in vitro transcription/translation system or in a host cell when the vector is introducedinto the host cell. The term "regulatory sequence" will include promoters, enhancers and other expression control elements (e.g., polyadenylation signals). Such regulatory sequences are described, for example, in Goeddel; gene Expression Technology: methods in Enzymology 185, academic Press, San Diego, Calif. (1990). Regulatory sequences include those which direct constitutive expression of a nucleotide sequence in many types of host cells, as well as those which direct expression of the nucleotide sequence in certain host cells. Preferred regulatory sequences are, for example, start-upExamples of substituents are cos-, tac-, trp-, tet-, trp-tet, lpp-, lac-, lpp-lac, lacI^q-、T7-、T5-、T3-、gal-、trc-、ara-、SP6-、arny、SPO2、λ-P_R-or λ P_LOther regulatory sequences are, for example, promoters from yeast and fungi, such as ADC1, MF α, AC, P-60, CYC1, GAPDH, TEF, rp28, ADH, promoters from plants, such as the CaMV/35S, SSU, OCS, lib4, usp, STLS1, B33, nos, or ubiquitin promoters, or phaseolin promoters.

The recombinant expression vectors of the invention can be designed for expression of MCT proteins in prokaryotic or eukaryotic cells. For example, heterologous Gene expression in filamentous Fungi can be found in bacterial cells such as Corynebacterium glutamicum, insect cells (using baculovirus expression vectors), Yeast and other fungal cells (see Romanos, M.A. et al (1992) "Yeast: review", Yeast 8: 423-488; van den Hondel, C.A.M.J.J.et al (1991) "heterologous Gene expression" in Gene management in Fungi, J.W.Bennet and L.L.Lasure, page 396-428: Academic Press: San Diego and van den, C.A.M.J.J.and Punt, P.J. (1991), "Gene transfer System and vector development for filamentous Fungi", in Applied Molecular Genetics of culture, P.DY.F.E., P.E.M.J.J.and P.8978. (1991) "transgenic cells of Agrobacterium, Cell culture, P.28-28, Cell culture, and Plant Cell culture (see Agrobacterium) in vitro, Plant In the cells, MCT gene is expressed. Suitable host cells are described in Goeddel, Gene Expression Technology: methods in enzymology 185, Academic Press, San Diego, Calif. (1990) are further described. Alternatively, the recombinant expression vector can be transcribed and translated in vitro, for example, using T7 promoter regulatory sequences and T7 polymerase.

Protein expression in prokaryotes is most often performed using vectors containing constitutive or inducible promoters directing expression of either fusion or non-fusion proteins. Fusion vectors add multiple amino acids to the protein encoded therein, typically to the amino terminus of the recombinant protein, but also to the C-terminus, or are fused in appropriate regions in the protein. Such fusion vectors are commonly used for three purposes: 1) to increase expression of the recombinant protein; 2) to increase the solubility of the recombinant protein; and 3) to facilitate purification of the recombinant protein by use as a ligand in affinity purification. Typically, in fusion expression vectors, a protease cleavage site is introduced at the junction of the fusion moiety and the recombinant protein to enable separation of the recombinant protein from the fusion moiety for subsequent purification of the fusion protein. Such enzymes and their associated recognition sequences include factor Xa, thrombin and enterokinase.

Typical fusion expression vectors include pGEX (Pharmacia Biotech Inc; Smith, D.B., and Johnson, K.S (1988) Gene 67: 31-40), pMAL (New England Biolabs, Beverly, MA), and pRIT5(Pharmacia, Piscataway, N.J.), which fuse glutathione S-transferase (GST), maltose E binding protein, or protein A, respectively, to the target recombinant protein. In one embodiment, the coding sequence of the MCT protein is cloned into a pGEX expression vector to produce a vector encoding a fusion protein comprising, from N-terminus to C-terminus, GST-thrombin cleavage site-X protein. The fusion protein can be purified by affinity chromatography using glutathione-agarose resin. Recombinant MCT proteins that are not fused to GST can be recovered by cleaving the fusion protein with thrombin.

Examples of suitable inducible non-fusion E.coli expression vectors include pTrc (Amann et al, (1988) Gene 69: 301-315), pLG338, pACYC184, pBR322, pUC18, pUC19, pKC30, pRep4, pHS1, pHS2, pPLc236, pMBL24, pLG200, pUR290, pIN-III113-B1, lambda gt11, pBdC1, and pET11d (Studier et al, Gene expression Technology: Methods in Enzymology 185, Academic Press, SanDiego, California (1990) 60-89; and Pouwels et al (1985) Cloning vectors. Expression of the target gene from the pTrc vector is dependent on host RNA polymerase transcription from the hybrid trp-lac fusion promoter. Expression of the target gene from the pET11d vector was dependent on transcription of the T7 gn10-lac fusion promoter mediated by co-expressed viral RNA polymerase (T7 gn 1). This viral polymerase is supplied by host strain BL21(DE3) or HMS174(DE3) from a resident (residual) lambda prophage containing the T7 gn1 gene under the transcriptional control of the lacUV5 promoter. For transformation of other bacterial varieties, suitable vectors may be selected. For example, it is known that plasmids pIJ101, pIJ364, pIJ702 and pIJ361 can be used for transforming Streptomyces (Streptomyces), and that plasmids pUB110, pC194 or pBD214 are suitable for transforming Bacillus (Bacillus) species. Several plasmids used to transfer genetic information to Corynebacterium include pHM1519, pBL1, pSA77 or pAJ667(Pouwels et al (1985) Cloning vectors. Elsevier: New York IBSN 0444904018).

One strategy to maximize recombinant protein expression is to express the protein in a host bacterium with an impaired ability to proteolytically cleave the recombinant protein (Gottesman, S., Gene expression Technology: Methods in Enzymology 185, Academic Press, SanDiego, Calif. (1990)119-"128). Another strategy is to alter the Nucleic acid sequence of the Nucleic acid to be inserted into an expression vector such that the individual codons for each amino acid are those preferentially used in the bacterium selected for expression (e.g., C.glutamicum) (Wada et al (1992) Nucleic Acids Res.20: 2111-2118). Such alteration of the nucleic acid sequence of the invention can be carried out using standard DNA synthesis techniques.

In another embodiment, the MCT protein expression vector is a yeast expression vector. Examples of vectors for expression in the yeast Saccharomyces cerevisiae (S.cerevisiae) include pYepSecl (Baldari et al (1987) Embo J.6: 229. quadrature. 234), 2. mu., pAG-1, Yep6, Yep13, pEMBLYe23, pMFa (Kurjan and Herskowitz (1982) Cell 30: 933. quadrature. 943), pJRY88(Schultz et al (1987) Gene 54: 113. quadrature. 123) and pYES2(Invitrogen corporation, San Diego, CA). Vectors and methods of construction of vectors suitable for use in other fungi, such as filamentous fungi, include those detailed in the following references: van den hondel, c.a.m.j.j. and Punt, P.J. (1991) "gene transfer system and vector development for filamentous fungi", are described in: applied Molecular Genetics of Fungi, J.F.Peberdy et al, pages 1-28, Cambridge Universal Press: cambridge, and Pouwels et al (1985) Cloning vectors, Elsevier: new York (IBSN 0444904018).

Alternatively, the MCT proteins of the invention can be expressed in insect cells using baculovirus expression vectors. Baculovirus vectors that can be used for protein expression in cultured insect cells (e.g., Sf9 cells) include the pAc series (Smith et al (1983) mol. cell biol. 3: 2156-2165) and the pVL series (Lucklow and Summers (1989) Virology 170: 31-39).

In another embodiment, the MCT proteins of the invention can be expressed in unicellular plant cells (e.g., algae) or in plant cells from higher plants (e.g., seed plants,such as crops). Examples of plant expression vectors include those detailed in the following documents: becker, d., Kemper, e., Schell, j., and Masterson, R. (1992) "novel Plant binary vector with selectable marker located adjacent to the left border", Plant mol.biol.20: 1195-1197; and Bevan, M.W (1984) "agrobacterium binary vector for plant transformation", nuclear.acid res.12: 8711-8721, and includes pLGV23, pGHlac +, pBIN19, pAK2004, and pDH51(Pouwels et al (1985) Cloning vectors. Elsevier: New YorkIBSN 0444904018).

In yet another embodiment, the nucleic acids of the invention are expressed in mammalian cells using a mammalian expression vector. Examples of mammalian expression vectors include pCDM8(Seed, B. (1987) Nature 329: 840) and pMT2PC (Kaufman et al (1987) EMBO J.6: 187-195). When used in mammalian cells, the control functions of the expression vector are typically provided by viral regulatory elements. For example, commonly used promoters are derived from polyoma virus, adenovirus 2, cytomegalovirus and simian virus 40. For other suitable expression systems for prokaryotic and eukaryotic cells, see Sambrook, j., Fritsh, e.f. and manitis, t.molecular Cloning: ALABORT MANUAL. 2 nd edition, chapters 16 and 17, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989.

In another embodiment, the mammalian recombinant expression vector is capable of directing the nucleic acid to be preferentially expressed in a particular cell type (e.g., the nucleic acid is expressed with tissue-specific regulatory elements). Tissue-specific regulatory elements are known in the art. Non-limiting examples of suitable tissue-specific promoters include the albumin promoter (liver-specific; Pinkert et al (1987) Genes Dev.1: 268-277), the lymph (lymphoid) specific promoter (Calame and Eaton (1988) adv.43: 235-275), the promoter of especially the T Cell receptor (Winto and Baltimore (1989) EMBO J.8: 729-733) and the promoter ofimmunoglobulins (Banerji et al (1983) Cell 33: 729-740; Queen and Baltimore (1983) Cell 33: 741-748), neuron-specific promoters (e.g., neurofilament promoter; Byrne and Rudd (1989) PNAS 86: 5473-5477), pancreas-specific promoters (Edlund et al (1985) Science 230: 912-916) and mammary gland-specific promoters (e.g., U.S. Pat. Pub. No. 4,873,264,166). Also included are developmentally regulated promoters, such as the murine hox promoter (Kessel and Gruss (1990) Science 249: 374-379) and the alpha fetoprotein promoter (Campes and Tilghman (1989) Genes Dev.3: 537-546).

The invention also provides a recombinant expression vector comprising a DNA molecule of the invention cloned into the expression vector in an antisense orientation. That is, the DNA molecule is operably linked to a regulatory sequence in a manner that provides for expression of an RNA molecule that is antisense to MCT mRNA (by transcription of the DNA molecule). Regulatory sequences operably linked to the antisense-directed cloned nucleic acid, which direct the continuous expression of the antisense RNA molecule in a variety of cell types, such as viral promoters and/or enhancers, may be selected, or regulatory sequences may be selected which direct constitutive, tissue-specific, or cell type-specific expression of the antisense RNA. Antisense expression vectors can be in the form of recombinant plasmids, phagemids or attenuated viruses in which antisense nucleic acids are produced under the control of highly effective regulatory regions, the activity of which can be determined by the cell type into which the vector is introduced. For a discussion of regulation of gene expression using antisense genes, see Weintraub, H.et al, antisense RNA as a molecular tool for genetic analysis, Reviews-Trends in Genetics, Vol.1 (1), 1986.

Another aspect of the invention relates to a host cell into which a recombinant expression vector of the invention has been introduced. The terms "host cell" and"recombinant host cell" are used interchangeably herein. It is understood that such terms refer not only to the particular subject cell, but also to the progeny or potential progeny of such a cell. Because certain modifications may occur in succeeding generations due to either mutation or environmental influences, such progeny may not, in fact, be identical to the parent cell, but are still included within the scope of the term as described herein.

The host cell may be any prokaryotic or eukaryotic cell. For example, MCT proteins can be expressed in bacterial cells such as corynebacterium glutamicum, insect cells, yeast cells, or mammalian cells (e.g., chinese hamster ovary Cells (CHO) or COS cells). Other suitable host cells are known to those skilled in the art. Microorganisms which are related to Corynebacterium glutamicum and which can be used advantageously as host cells for the nucleic acid and protein molecules according to the invention are shown in Table 3.

Vector DNA can be introduced into prokaryotic or eukaryotic cells by conventional transformation or transfection techniques. The terms "transformation" and "transfection", "conjugation" and "transduction" as used herein refer to a variety of techniques known in the art for introducing nucleic acids of foreign nucleic acids (e.g., linear DNA or RNA (e.g., linearized vector or vector-free separate gene construct)) or vector forms (e.g., plasmids, phages, phagemids (phasmids), phagemids (phagemds), transposons or other DNA) into host cells, including calcium phosphate or calcium chloride co-precipitation, DEAE-dextran-mediated transfection, lipofection, natural competence, chemical-mediated transfer or electroporation. Suitable methods for transforming or transfecting host cells can be found in Sambrook et al (molecular cloning: A Laboratory Manual, 2 nd edition, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1989) and other protocols.

With regard to stable transfection of mammalian cells, it is known that, depending on the expression vector and transfection technique used, only a small fraction of cells can integrate the foreign DNA into their genome. To identify and select these integrants, a gene encoding a selectable marker (e.g., antibiotic resistance) is typically introduced into the host cell along with the gene of interest. Preferred selectable markers include those that confer resistance to drugs such as G418, hygromycin and methotrexate. The nucleic acid encoding the selectable marker can be introduced into the host cell on the same vector as that encoding the MCT protein, or it can be introduced on a separate vector. Cells stably transfected with the introduced nucleic acid can be identified, for example, by drug selection (e.g., cells that have incorporated the selectable marker gene will survive, while other cells die).

To produce a homologous recombinant microorganism, a vector is prepared that contains at least a portion of an MCT gene into which other deletions, additions or substitutions have been introduced to thereby alter (e.g., functionally disrupt) the MCT gene. Preferably, the MCT gene is a corynebacterium glutamicum MCT gene, but it may be a homologue from related bacteria or even from mammalian, yeast or insect sources. In a preferred embodiment, the vector is designed such that, upon homologous recombination, the endogenous MCT gene is functionally disrupted (i.e., no longer encodes a functional protein; also referred to as a "knock-out" vector). Alternatively, the vector can be designed such that, following homologous recombination, the endogenous MCT gene is mutated or altered, but still encodes a functional protein (e.g., the upstream regulatory region can be altered to thereby alter expression of the endogenous MCT protein). In the homologous recombination vector, the altered portion of the MCT gene is flanked at its 5 'and 3' ends by nucleic acid of another MCT gene, enabling homologous recombination to occur between the exogenous MCT gene carried by the vector and the endogenous MCT gene in the microorganism. The additional flanking MCT nucleic acids are of sufficient length for successful homologous recombination with the endogenous gene. Typically, several kilobases of flanking DNA (5 'end as well as 3' end) are included in the vector (see, e.g., Thomas, K.R. and Capecchi, M.R, (1987) Cell 51: 503 for a description of homologous recombinant vectors). The vector is introduced into the microorganism (e.g., by electroporation) and cells in which the introduced MCT gene has homologously recombined with the endogenous MCT gene are then selected using techniques known in the art.

In another embodiment, a recombinant microorganism may be produced containing a selected system that provides for modulated expression of an introduced gene. For example, inclusion of an MCT gene under the control of a lac operator on a vector allows expression of the MCT gene only in the presence of IPTG. Such regulation systems are well known in the art.

In another embodiment, the endogenous MCT gene in the host cell is disrupted (e.g., by homologous recombination or other genetic methods known in the art) such that expression of its protein product does not occur. In another embodiment, the MCT gene endogenous or introduced in the host cell has been altered by one or more point mutations, deletions, or inversions, but it still encodes a functional MCT protein. In yet another embodiment, one or more regulatory regions (e.g., a promoter, a repressor, or an inducer) of an MCT gene in a microorganism are altered (e.g., by deletion, truncation, inversion, or point mutation) such that expression of the MCT gene is modulated. Those skilled in the art will recognize that host cells containing more than one such MCT gene and protein modification can be readily produced using the methods of the invention and are intended to be included within the invention.

Host cells of the invention (e.g., prokaryotic host cells or eukaryotic host cells in culture) can be used to produce (i.e., express) MCT proteins. Accordingly, the invention also provides methods for producing MCT proteins using the host cells of the invention. In one embodiment, the method comprises culturing a host cell of the invention (into which a recombinant expression vector encoding an MCT protein has been introduced, or into which a genome has been introduced a gene encoding a wild-type or altered MCT protein) in a suitable medium until the MCT protein is produced. In another embodiment, the method further comprises isolating the MCT protein from the culture medium or from the host cell. C. Isolated MCT proteins

Another aspect of the invention relates to isolated MCT proteins and biologically active portions thereof. An "isolated" or "purified" protein or biologically active portion thereof is substantially free of cellular material when produced by recombinant DNA techniques, or substantially free of chemical precursors or other chemicals when chemically synthesized. The phrase "substantially free of cellular material" includes preparations of MCT protein in which the protein is separated from cellular components that are naturally or recombinantly produced in the cell. In one embodiment, the phrase "substantially free of cellular material" includes preparations of MCT protein having less than about 30% (by dry weight), more preferably less than 20%, even more preferably less than about 10%, and most preferably less than about 5% non-MCT protein (also referred to herein as "contaminating protein"). When the MCT protein, or biologically active portion thereof, is recombinantly produced, it is also preferably substantially free of culture medium, i.e., culture medium is less than about 20%, more preferably less than about 10%, and most preferably less than about 5%by volume of the protein preparation. The phrase "substantially free of chemical precursors or other chemicals" includes preparations of MCT proteins in which the MCT protein is separated from chemical precursors or other chemicals involved in the synthesis of the protein. In one embodiment, the phrase "substantially free of chemical precursors or other chemicals" includes preparations of MCT protein having less than about 30% (by dry weight), more preferably less than 20%, even more preferably less than about 10%, and most preferably less than about 5% chemical precursors or non-MCT chemicals. In a preferred embodiment, the isolated protein or biologically active portion thereof is free of contaminating proteins from the same organism from which the MCT protein is derived. Typically, such proteins are produced by recombinant expression of, for example, a corynebacterium glutamicum MCT protein in a microorganism, such as corynebacterium glutamicum.

The isolated MCT protein of the invention, or a portion thereof, can be involved in the metabolism of compounds essential for the cell membrane formation of c.glutamicum or in molecular transport across these membranes, or have one or more of the activities described in table 1. In a preferred embodiment, the protein or a part thereof comprises an amino acid sequence sufficiently homologous to an amino acid sequence according to the invention (for example an even-numbered SEQ ID NO sequence of the sequence listing) such that the protein or a part thereof retains the ability to participate in the metabolism of compounds essential for the cell membrane formation of c.glutamicum or in the transport of molecules across these membranes. Preferably, said portion of said protein is a biologically active portion as described herein. In another preferred embodiment, the MCT protein of the invention has an amino acid sequence as set forth in an even-numbered seq id NO of the sequence listing. In yet another preferred embodiment, the MCT protein has an amino acid sequence encoded by a nucleotide sequence that hybridizes (e.g., hybridizes under stringent conditions) to a nucleotide sequence of the present invention (e.g., the sequence set forth as odd-numbered SEQ ID NOs of the sequence listing). In yet another preferred embodiment, the MCT protein has an amino acid sequence, or portion thereof, encoded by a nucleotide sequence that is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to a nucleic acid sequence of the invention. The invention also includes ranges between the above values and the identifying values (e.g., 70-90% identical or 80-95% identical). For example, ranges of identification values that include any combination of the above values as upper and/or lower limits are intended to be included. Preferred MCT proteins of the invention also preferably have at least one MCT activity as described herein. For example, preferred MCT proteins of the invention include amino acid sequences encoded by nucleotide sequences that hybridize to a nucleotide sequence of the invention, e.g., under stringent conditions, and may be involved in the metabolism of compounds essential for the cell membrane formation of c.glutamicum or in the transport of molecules across such membranes, or have one or more of the activities described in table 1.

In other embodiments, the MCT protein is substantially homologous to one of the amino acid sequences of the invention (e.g., the even-numbered SEQ ID NO sequences in the sequence listing), and retains the functional activity of the protein of one of the amino acid sequences of the invention, but differs in the amino acid sequence due to natural variation or mutagenesis, as described in detail in section I above. Thus, in another embodiment, the MCT protein is a protein having an amino sequence that is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, even more preferably at least about 95%, 96%, 97%, 98%, 99%, or more homologous to a complete amino acid sequence of the invention, and having at least one MCT activity described herein. The invention also includes ranges between the above values and the identifying values (e.g., 70-90% identical or 80-95% identical). For example, ranges of identification values that include any combination of the above values as upper and/or lower limits are intended to be included. In another embodiment, the invention relates to full-length corynebacterium glutamicum proteins that are substantially homologous to one of the complete amino acid sequences of the present invention.

Biologically active portions of MCT proteins include peptides comprising an amino acid sequence derived from an amino acid sequence of an MCT protein (e.g., an amino acid sequence of an even-numbered SEQ ID NO in the sequence listing), or an amino acid sequence of a protein that is homologous to an MCT protein, including less than a full-length MCT protein or a full-length protein that is homologous to an MCT protein, and exhibiting at least one MCT protein activity. Typically, the biologically active portion (a peptide, e.g., a peptide of, e.g., 5, 10, 15, 20, 30, 35, 36, 37, 38, 39, 40, 50, 100, or more amino acids in length) comprises a domain or motif having the activity of at least one MCT protein. In addition, other biologically active portions in which other regions of the protein are deleted can be prepared by recombinant techniques and evaluated for one or more of the activities described herein. Preferably, the biologically active portion of the MCT protein comprises one or more selected domains/motifs or portions thereof that have biological activity.

The MCT protein is preferably produced by recombinant DNA techniques. For example, a nucleic acid molecule encoding the protein is cloned into an expression vector (as described above), the expression vector is introduced into a host cell (as described above), and the MCT protein is then expressed in the host cell. The MCT protein can then be isolated from the cells by an appropriate purification scheme using standard protein purification techniques. As an alternative to recombinant expression, MCT proteins, polypeptides or peptides can be chemically synthesized using standard peptide synthesis techniques. In addition, native MCT proteins can be isolated from cells (e.g., endothelial cells), for example, using anti-MCT antibodies produced using the MCT proteins of the invention, or fragments thereof, by standard techniques.

The invention also provides MCT chimeric proteins or fusion proteins. An MCT "chimeric protein" or "fusion protein" as used herein comprises an MCT polypeptide operably linked to a non-MCT polypeptide. "MCT polypeptide" refers to a polypeptide having an amino acid sequence corresponding to an MCT protein, while "non-MCT polypeptide" refers to a polypeptide having an amino acid sequence corresponding to a protein that is substantially non-homologous to the MCT protein, e.g., a protein that is different from the MCT protein and is derived from the same organism or a different organism. In the fusion protein, the term "operably linked" even means that the MCT polypeptide and the non-MCT polypeptide are fused in-frame to each other. The non-MCT polypeptide can be fused to the N-terminus or C-terminus of the MCT polypeptide. For example, in one embodiment, thefusion protein is a GST-MCT fusion protein in which the MCT sequence is fused to the C-terminus of the GST sequence. Such fusion proteins can facilitate purification of recombinant MCT proteins. In another embodiment, the fusion protein is an MCT protein comprising a heterologous signal sequence at its N-terminus. In certain host cells (e.g., mammalian host cells), expression and/or secretion of MCT proteins can be increased by the use of heterologous signal sequences.

Preferably, the MCT chimeric proteins or fusion proteins of the invention are produced using standard recombinant DNA techniques. For example, DNA fragments encoding the different polypeptide sequences are ligated together in-frame according to conventional techniques, e.g., by ligation using blunt-ended or staggered nicked ends, restriction enzyme digestion to provide appropriate ends, appropriate filling of cohesive ends, alkaline phosphatase treatment to avoid unwanted ligation, and enzymatic ligation. In another embodiment, the fusion gene may be synthesized by conventional techniques, including automated DNA synthesizers. Alternatively, PCR amplification of gene fragments is performed using anchor primers that create complementary overhangs between two consecutive gene fragments that are subsequently annealed and re-amplified to generate chimeric gene sequences (see, e.g., Current Protocols in Molecular Biology, Ausubel et al, John Wiley&Sons: 1992). In addition, many expression vectors are commercially available that already encode a fusion moiety (e.g., a GST polypeptide). MCT-encoding nucleic acids can be cloned into such an expression vector such that the fusion moiety is linked in-frame to the MCT protein.

Homologs of the MCT proteins can be generated by subjecting the MCT proteins to mutagenesis, e.g., discrete point mutations or truncation. The term "homologue" as used herein refers to a variant form of the MCT protein that acts as an agonist or antagonist of the MCT protein activity. Agonists of the MCT protein can retain substantially the same biological activity or a subset of the biological activity of the MCT protein. Antagonists of the MCT protein may inhibit one or more activities of the naturally-occurring form of the MCT protein, for example, by competitively binding to members downstream or upstream of the metabolic cascade of cellular membrane components that include the MCT protein, or by binding to MCT proteins that mediate transport of compounds across such membranes, thereby preventing transport from occurring.

In an alternative embodiment, homologs of the MCT protein may be identified by screening combinatorial libraries of mutants, e.g., truncated mutants, of the MCT protein that have agonist or antagonist activity of the MCT protein. In one embodiment, a variegated library (variegated library) of MCT variants encoded by a variegated gene library is generated by performing combinatorial mutagenesis at the nucleic acid level. MCT variant variegated libraries can be generated by, for example, enzymatically ligating a synthetic oligonucleotide mixture into a gene sequence such that a degenerate set of potential MCT sequences can be expressed as a single polypeptide, or as a set of larger fusion proteins containing a set of MCT sequences therein (e.g., for phage display). There are a variety of methods that can be used to generate libraries of potential MCT homologs from a degenerate oligonucleotide sequence. Chemical synthesis of a degenerate gene sequence can be performed in an automated DNA synthesizer and the synthetic gene can then be ligated into a suitable expression vector. The use of a degenerate set of genes allows the provision of all sequences encoding a desired set of potential MCT sequences in one mixture. Methods for synthesizing degenerate oligonucleotides are known in the art (see, e.g., Narang, S.A. (1983) Tetrahedron 39: 3; Itakura et al (1984) Annu. Rev. biochem.53: 323; Itakuraet al (1984) Science 198: 1056; Ike et al (1983) Nucleic Acid Res.11: 477).

In addition, the library of fragments encoded by the MCT protein can be used to generate a population of plaques of MCT fragments for screening and subsequent selection of homologs of the MCT protein. In one embodiment, a library of coding sequence fragments can be generated by treating double-stranded PCR fragments of MCT coding sequences with a nuclease under conditions in which only one nick per molecule occurs, denaturing the double-stranded DNA, renaturing the DNA to form double-stranded DNA that can include sense/antisense pairs from different nicked products, removing single-stranded portions from the reformed duplexes by treatment with S1 nuclease, and then ligating the resulting fragment library into an expression vector. In this way, an expression library can be obtained which encodes the N-terminal, C-terminal and internal fragments of the MCT protein of various sizes.

Several techniques are known in the art for screening gene products of combinatorial libraries made by point mutations or truncation, and for screening cDNA libraries for gene products having selected properties. Such techniques are suitable for rapid screening of gene libraries generated by combinatorial mutagenesis of MCT homologs. The most widely used techniques for screening large gene libraries, suitable for high throughput analysis, typically involve cloning the gene library into a replicative expression vector, transforming appropriate cells with the resulting library of vectors, and expressing the combinatorial genes under conditions such that detection of the desired activity facilitates isolation of the vector encoding the gene whose gene product is being detected. Cyclic ensemble mutagenesis (REM) is a novel technique to increase the frequency of functional mutants in libraries, and can be used in conjunction with screening assays to identify MCT homologs (Arkin and Yourvan (1992) PNAS 89: 7811. multidot. 7815; Delgrave et al (1993) Protein Engineering 6 (3: 327. multidot. 331).

In another embodiment, a plaque MCT library can be analyzed using cell-based assays using methods well known in the art. D. Applications and methods of the invention

The nucleic acid molecules, proteins, protein homologs, fusion proteins, primers, vectors, and host cells described herein can be used in one or more of the following methods: identification of corynebacterium glutamicum and related organisms; mapping the genome of an organism associated with Corynebacterium glutamicum; identification and localization of corynebacterium glutamicum sequences of interest; evolution research; determination of MCT protein regions required for function; modulation of MCT protein activity; modulation of the metabolism of one or more cell membrane components; modulation of membrane transport of one or more compounds; and regulation of the production of the desired compound (e.g.a fine chemical) by the cell.

The MCT nucleic acid molecules of the invention have a variety of uses. First, they can be used to identify organisms that are Corynebacterium glutamicum or closely related species thereof. In addition, they can be used to identify the presence of Corynebacterium glutamicum or a related species in a mixed population of microorganisms. The present invention provides nucleic acid sequences of a plurality of genes of Corynebacterium glutamicum; by probing the extracted genomic DNA of a specific population of microorganisms or a culture of a mixed population of microorganisms under stringent conditions with probes spanning the gene region of c.

Although Corynebacterium glutamicum itself is nonpathogenic, it is associated with pathogenic species such as Corynebacterium diphtheriae. Corynebacterium diphtheriae is a rapidly developing pathogen ofacute febrile infection, diphtheria, involving both local and systemic pathology. In this disease, localized lesions develop in the upper respiratory tract, including necrotic damage to epithelial cells; the bacilli secrete toxins, which diffuse through the lesions to the distal susceptible tissues of the body. The resulting degenerative changes contribute to the systemic pathology of the disease by inhibiting protein synthesis in these tissues, including the heart, muscle, peripheral nerves, adrenal glands, kidney, liver and spleen. Diphtheria has been highly prevalent in many parts of the world, including africa, asia, the eastern part of europe, and many independent states of the former soviet union. Since 1990, one diphtheria epidemic in the latter two areas has resulted in at least 5,000 deaths.

In one embodiment, the invention provides a method of identifying the presence or activity of corynebacterium diphtheriae in a subject. Such a method comprises detecting one or more of the nucleic acid sequences or amino acid sequences of the invention (e.g., as set forth in odd-numbered or even-numbered seq id NOs, respectively, of the sequence listing) in a subject, thereby detecting the presence or activity of corynebacterium diphtheriae in the subject. Corynebacterium glutamicum and corynebacterium diphtheriae are related bacteria, and many of the nucleic acid and protein molecules in corynebacterium glutamicum are homologous to the nucleic acid and protein molecules of corynebacterium diphtheriae, and thus can be used to detect corynebacterium diphtheriae in a subject.

The nucleic acid molecules and protein molecules of the invention can also be used as markers for specific regions of the genome. The method can be applied to genome mapping and functional research of Corynebacterium glutamicum protein. For example, to identify the region of the genome to which a particular C.glutamicum DNA binding protein binds, the C.glutamicum genome may be digested and the fragment incubated with the DNA binding protein. Those regions which bind to the protein can additionally be probed with the nucleic acid molecules of the invention, preferably with readily detectable labels; the binding of such nucleic acid molecules to the genomic fragments enables the mapping of the above fragments onto the genomic map of C.glutamicum and, when performed several times with different enzymes, facilitates the rapid determination of the nucleic acid sequence to which the proteins bind. Furthermore, the nucleic acid molecules of the invention may have sufficient homology to the sequences of the relevant species, and therefore these nucleic acid molecules may be used as markers for the construction of genomic maps in relevant bacteria, such as Brevibacterium lactofermentum.

The MCT nucleic acid molecules of the invention can also be used for evolutionary studies and protein structure studies. A wide variety of prokaryotic and eukaryotic cells utilize the metabolic and transport processes in which the molecules of the invention participate; by comparing the sequences of the nucleic acid molecules of the invention with those from other organisms which code for similar enzymes, the evolutionary relevance of the organisms can be assessed. Again, this comparison allows the evaluation of which regions of the sequence are conserved and which regions are not, which helps to determine the regions of the protein that are essential for enzyme function. This type of assay is valuable for protein engineering studies and can give an indication that proteins can be tolerated in mutagenesis without loss of function.

Manipulation of the MCT nucleic acid molecules of the invention can result in the production of MCT proteins that are functionally distinct from wild-type MCT proteins. These proteins may be improved in efficiency or activity, may be present in the cell in an amount greater than usual, or maybe reduced in efficiency or activity.

The present invention provides screening methods for screening for molecules that modulate the activity of an MCT protein, either by interacting with the protein itself or a substrate or binding partner of the MCT protein, or by modulating transcription or translation of an MCT nucleic acid molecule of the invention. In such methods, a microorganism expressing one or more MCT proteins of the invention is contacted with one or more test compounds, and the effect of each test compound on the activity or expression level of the MCT protein is evaluated.

There are various mechanisms by which alteration of the MCT proteins of the invention may directly affect the yield, production and/or production of a fine chemical from a strain of Corynebacterium glutamicum into which such altered proteins have been incorporated. If the Corynebacterium glutamicum secretes the desired compound, the recovery of the fine chemical compound from large-scale cultures of Corynebacterium glutamicum is significantly improved, since this compound can be easily purified from the culture medium (as opposed to being extracted from the C.glutamicum cell mass). By either increasing the number or the activity of transporter molecules which export a fine chemical out of the cell, it is possible to increase the amount of the resulting fine chemical present in the extracellular medium and thus to make collection and purification easier. In contrast, in order to efficiently overproduce one or more fine chemicals, increased amounts of cofactors, precursor molecules and intermediate compounds of the appropriate biosynthetic pathway are required. Thus, by increasing the number and/or activity of transporters involved in the import of nutrients, such as carbon sources (i.e.sugars), nitrogen sources (i.e.amino acids, ammonium salts), phosphoric acid and sulfur, it is possible to improve the production of fine chemicals, sincethe restrictions on the supply of any nutrients for the biosynthetic process are removed. Furthermore, fatty acids and lipids are themselves ideal fine chemicals, and it is therefore possible to increase the yield, production and/or productivity of fatty acid and lipid molecules from C.glutamicum by activity optimization or increase in the amount of one or more MCT proteins of the invention involved in the biosynthesis of these compounds, or by reduction in the activity of one or more MCT proteins involved in the degradation of these compounds.

Engineering of one or more MCT genes of the invention may also result in MCT proteins that alter activity, indirectly affecting the production of one or more desired fine chemicals from c. For example, normal biochemical processes of metabolism result in the production of various waste products (e.g., hydrogen peroxide and other reactive oxygen species) that may actively interfere with the metabolic process (e.g., peroxynitrite is known to nitrify tyrosine side chains, thereby inactivating certain enzymes having tyrosine at the active site (Groves, J.T. (1999) Curr. Opin. chem. biol.3 (2): 226-235.) although these waste products are typically excreted, Corynebacterium glutamicum strains used for large-scale fermentative production are optimized for overproduction of one or more fine chemicals and thus may produce more waste products than wild-type Corynebacterium glutamicum would normally have. Thus, by increasing the ability of a cell to secrete these compounds, the viability of the cell can be increased.

Furthermore, the MCT proteins of the invention can be manipulated so as to alter the relative amounts of the various lipids and fatty acid molecules produced. This may have a profound effect on the lipid composition of cell membranes. Since each type of lipid has different physical properties, changes in membrane lipid composition can significantly alter membrane fluidity. Changes in membrane fluidity can affect molecular transport across the membrane, which, as previously mentioned, can alter the output of waste or produced fine chemicals or the input of essential nutrients. Such changes in membrane fluidity can also significantly affect the integrity of the cells; cells with relatively weak membranes are more susceptible to mechanical stress in a large-scale fermentor environment, which can damage or kill the cells. By manipulating the MCT proteins involved in the production of membrane-forming fatty acids and lipids, so that the membrane composition of the resulting membrane is more adapted to the environmental conditions present in the culture used for the production of the fine chemical, a greater proportion of the c.glutamicum cells should survive and multiply. A larger number of C.glutamicum cells in culture should be converted into a larger yield, production or productivity of the fine chemical from said culture.

The above-mentioned strategy for mutagenesis of the MCT protein, which leads to an improved yield of fine chemicals from C.glutamicum, is not intended to be limiting; variations of these strategies will be apparent to those skilled in the art. Using these strategies and incorporating the mechanisms disclosed herein, nucleic acid molecules and protein molecules of the present invention can be utilized to produce corynebacterium glutamicum or related bacterial strains expressing mutant MCT nucleic acid molecules and protein molecules such that the yield, production, and/or productivity of a desired compound is improved. Such desired compounds may be any natural product of Corynebacterium glutamicum, including end products of biosynthetic pathways and intermediates of naturally occurring metabolic pathways, as well as molecules which do not naturally occur in the metabolism of Corynebacterium glutamicum but are produced by the Corynebacterium glutamicum strains of the present invention.

The invention is further illustrated by the following examples, which are not to be construed as limiting. The contents of all references, patent applications, patents, published patent applications, tables and sequence listings cited in this application are incorporated herein by reference.

Table 1: the gene nucleic acid amino acid identification code contig NT initiating NT termination function SEQ ID NO SEQ ID NO12 RXN03097 VV 00623557 ammonium transport System 34 RXA02099 GR 0063061986470 ammonium transport System 56 RXA00104 GR 000141589516650 CYSQ protein, the ammonium transporter polyketide synthesis nucleic acid identification code contig NT initiating NT termination function SEQ ID NO SEQ ID NO 78 RXA01420 GR 00475174 "-mycarosyl isovaleryl-CoA transferase (EC 2.-) 910N 581 VV 009882623 304623 polyketide synthase 1112 FRXA 152581 0074117 polyketide synthase 1314 RXA 02GR 007007411894110689719 possible polyketide synthase CY 338.201516A RX01138 GR 0031816572 actinomycetin polyketide dimerization enzyme (EC-) 1719A 171738 RXGR 17180 GR 0050198 RXB cyclizing synthase RXVVVVVVVVVV 1479 1478 F002753 38N 00238 GR 38 GR actinomycetin the amino acid identification code contig codon bindes Initiation of NT termination function SEQ ID NO SEQ ID NO 2324 RXA02335 GR 006725502322 Biotin carboxylase (EC 6.3.4.14) 2526 RXA02173 GR 0064174738924 acetyl-CoA carboxylase carboxytransferase subunit

β (EC 1.1.1.100) 2930 RXN 01764 GR 0051717831103-ketoacyl- [ acyl-carrier protein]reductase (EC 1.1.1.100) 2930 RXN02487 VV 0007636664 long-chain fatty acid-CoA ligase (EC 6.2.1.3) 3132 FRXA02487 GR 0071849374650 long-chain fatty acid-CoA ligase (EC 6.2.1.3) 3334 FR024XA 90 GR 007208175 long-chain fatty acid-CoA ligase (EC 6.2.1.3) 3536 RXA01467 GR 0049201210 acyl carrier protein 372238 RXA 007002122025 acyl carrier protein phosphodiesterase 3940 RXA01897 GR 0056171159 acylcarrier protein phosphodiesterase 4142 GR 09 VV 03426 GR EC2.3.1.39 9 GR 3635, phosphoric acid synthase (EC 1.000 EC2.3.1.39 9: EC2.3.1.39 9; RXN03 EC2.3.1.39 9 GR 3603 EC2.3.1.39 9; RXN03 EC2.3.1.39 9 GR 033603 EC2.3.1.39 9) fatty acid synthase (EC 1.4; EC 2.4,4735; FG EC2.3.1.39 9; FG 3635; FG 3603369; FG EC2.3.1.39 9; FG 369; FG 36

Table 1 (continuation) nucleic acid amino acid identification code contig NT start NT termination function DEQ ID NO SEQ ID NO 4950 RXN03111 VV 008460405 fatty acid synthase (EC 2.3.1.85) [ including: EC 2.3.1.38; EC 2.3.1.39; EC (EC)

The phospholipid synthase (EC 363672) 5556 RXA00158 GR 0002420884 fatty acid synthase (EC 4.2.1.61) 5354 FRXA00572 GR 0015526 GR 0078906066 a polyketide synthase CY 4.2.1.61 GR 360103566 GR 36003512 GR1 GR 360035533512 GR1 GR 36009266 GR folate reductase (EC 6.2.1.3) 6162 RXA 00296959595959595959595959 GR 369 GR 36353535359 GR 363536353535359 GR 363536010353535048 GR 3635569 GR 36353635363535048 GR 369 GR 3635569 GR 36353635363536353635048 GR 3635048 GR 369 GR 3635048 GR 369A No. 4 GR 3635048A No. 4O No. 4A No. 4O C3536353635048A phosphoacyl transferase (EC 363536353635043635043635048A 3635048A No. 4O C3635048C, IV, FQ, Fp, FQ, Fp, FQ, Fp, FQ, Fp, No. 4, Fp, No. 4, No. 4, Fp, No. 4, Fp, No. 4, Fp, No. 4, Fp, No. 4, Fp, No. 4

TABLE 1 (continuous) nucleic acid amino acid identification code contig NT start NT termination function SEQ ID NO 127128 RXA00801 GR 0021431383770 hydroxyacyl glutathione hydrolase (EC) RXA00821 GR 0022114692311 hydroxyacyl glutathione hydrolase (EC) RXN02966 VV 01405613462 hydroxyacyl glutathione hydrolase (EC) FRXA 011431431386260 hydroxyacyl glutathione hydrolase (EC) 135136 RXA01853 GR 00525615010 hydroxyacyl glutathione hydrolase (EC) RXN02424 V01157169 hydroxyacyl glutathione hydrolase (EC) FRXA02424 GR 00706808428 hydroxyglutathione hydrolase (EC) RXN 0042100112422422422422422422422422420 hydroxyacyl glutathione hydrolase (EC) reductase (EC) RXN02424 VXA 011570115701157169 hydroxyacyl glutathione hydrolase [ EC) pR 00419 GR folate]folate reductase (EC) RXbx carboxylase pA 010538102713553810046) reductase (EC) RXN 0046A carboxylase DNA lyase 92 GR 0007135H 01035H 92 PEG 3270H, O carboxylase synthetase (EC) DNA folate reductase 92R 01035H, DNA folate reductase (EC) RXn 01035H, DNA folate reductase (EC) FQ, DNA folate reductase DNA lyase) DNA lyase, DNA synthetase DNA folate reductase DNA lyase, folate reductase DNA, folate reductase, synthetase, folate reductase

2.3.1.41; EC 1.1.1.100; EC 4.2.1.61; EC 1.3.1.10; EC 3.1.2.14]171172 RXN02168 VV 0100289481 fatty acid synthase (EC 2.3.1.85) [ including: EC 2.3.1.38; EC 2.3.1.39; EC (EC)

2.3.1.41, EC 1.1.1.100, EC 4.2.1.61, EC 1.3.1.10, EC 3.1.2.14]173174 RXN01090 VV 015564835686 ketoacyl reductase HETN (EC 1.3.1-) 175176 RXN02062 VV 022231591990 lipopolysaccharide N-acetylglucosaminyltransferase 177178 RXN02148 VV 03001656117703 lipopolysaccharide N-acetylglucosaminyltransferase 179180 RXN02595 VV 00110989935 lipopolysaccharide N-acetylglucosaminyltransferase 181182 RXS00148 VV 0167981204959 methylmalonyl-CoA mutase α subunit (EC 5.4.99.2) 183184 RXSS 00149 VV 0167799542 methylmalonyl-CoA α subunit (EC 5.4.99.2) 185186 RXSS 02106 VV 32264049241929 lipocalin mutein A (EC 5.4.01859. RXN 0141859. RTM) is involved in the metabolism of lipocalin IV sulfooctanoate A0141350141357446A mutein

TABLE 1 (continuation) fatty acid degradation nucleic acid amino acid identification code contig NT start NT termination function SEQ ID NO 197198 RXA02268 GR 0065521823081 lipase (EC 3.1.1.3) 199200 RXA02269 GR 006559465 lipase (EC 3.1.1.3) 201202 RXA01614 GR 0044982197197 lysophospholipase L2(EC 3.1.1.5) 203204 RXA01983 GR 00573593053053 lipase (EC 3.1.1.3) 205206 RXN02947 VV 007813196 propionyl-CoA carboxylase β chain (EC 6.4.1.3) 207208 FRXA02320 GR 006675936 propionyl-CoA carboxylase β chain (EC 6.4.1.3) 209210 FR1521521521528546 propionyl-CoA carboxylase 6745 chain (EC 6.4.1.3) PX carboxylase 673577350735073535353535353535353535353535353535353535353535353538 carboxylase (EC 6.023 437735) carboxylase (EC 6.023 437735) carboxylase 437735 CX 437735 carboxylase (EC 6.35438135353535353535353535353535353535353535353535353535358) carboxylase (EC 6) carboxylase (EC 6.023 433535353535353535353535353535353535358) carboxylase (EC 6) carboxylase 4335353535353535353535353535358.353535353535358.358.358.357) carboxylase (EC 6) carboxylase (EC

1.2.1.27) 2-methyl-3-ketopropionic acid NAD + oxidoreductase (CoA-propionylation) 223224 RXA01260 GR 0036723811200 branched α -liponic acid dehydrogenase complex lipoamide dehydrogenase component (E3)

(EC 1.8.14) 225226 RXA01261 GR 0036726072437 Thioclamide dehydrogenase component of branched-chain α -keto acid dehydrogenase Complex (E3)

(EC 1.8.1.4) 227228 RXA01136 GR 003186851116 isovaleryl-CoA dehydrogenase (EC 1.3.99.10) 229230 RX00559 VV 010375686552 protein VDLD 231232 FRXA00559 GR 001492186 protein VDLD 233234 RXA01580 GR 004704076 glycerophosphodiester phosphodiesterase 235236 RXA02677 GR 0075431193877 glycerophosphodiester phosphodiesterase (EC 3.1.4.46) 237238 RXSS 01166 VV 01171814238 extracellular lipase precursor (EC 3.1.1.3) terpenoid biosynthetic nucleic acid amino acid overlap group NT start NT terminate function SEQ ID NO 23NO 23922392239240 RXA 00GR 0024124231857 isopentene diphosphate delta-isomerase (EC 5.3.3.3.3.2) 241242A 01292A 0127300312012042388 phytone dehydrogenase (EC 1.3. RXR 0036741923970A 00341673A 0034170416520 geranyl dehydrogenase (EC 1.3.41054170354135413.3).

TABLE 1 (continuation) nucleic acid amino acid identifier code contig NT initiating NT termination function SEQ ID NO SEQ ID NO 249250 RXA01067 GR 0029814532181 undecaprene diphosphate synthase (EC 2.5.1.31) 251252 RXA01269 GR 003672033419894 undecaprene phosphate galactosyltransferase

(EC 2.7.8.6) 253254 RXA01250 GR 003643533 putative undecaprenyl phosphate α -N-

The proteins of acetyl glucosyltransferase (EC 2.4.1.) -RXA 01576 GR 0043880538811 polyterpene (dolichyl) phosphate-glucosyltransferase (EC) RXN02309 VV 00252849329542 octeprrenyl-diphosphate synthase (EC 2.5.1.) -FRXA 02309 GR 0066584 octeprrenyl-diphosphate synthase (EC 2.5.1.) -RXN 004008677 GR 0537octahydrolycopene dehydrogenase (EC 1.3. -) FRATP 0049 GR 001318714 phytoene dehydrogenase (EC 1.3. -) RXGR 004004GR 00478 GR 001191010014023190 phytoene synthase (EC 2.5.1. GR 00400100400100400192534392277 Xa) and the proteins of the transfer protein of ATP 329292 ATP, ATP 329253435446, ATP patchouli transferase, ATP patchouli, ABC 3253435435533553355346, ATP patchouli, ATP, patchouli, ATP, patchouli, ATP, patchouli, the transfer protein of the subunit, ATP, patchouli

TABLE 1 (continuation) nucleic acid amino acid identification code contig NT initial NT termination function of the ATP-initiating ATPase SEQ ID NO SEQ ID NO 317318 FRXA 02GR 0073614692497 ABC transporter, of the P, G, R ATPase subunit 319320 RXN02074 VV 03181277511153 transporter ATP binding protein CYDD 321322 FRXA02074 GR 0062857984176 ABC transporter, of the P, G, R ATPase subunit 323324 RXA02095 GR 006407115474 ABC transporter, of the P, G, R ATPase subunit 325326 RXA 25 GR 5231562275 transporter, of the P, G, R ATPase subunit 327328 RXA GR 53 GR 542048021406 transporter, of the P, G, R ATPase subunit 329330N 01881 GR 647 GR 010552995 putative ABC transporter binding protein ABC binding protein FtPase 331332 FRXA01881 GR 3000135001350013500133 RG GCA 00735001350013500733 putative ATP binding protein ABC 00736007360073600733 binding protein FHGA 3500736007923500135001350013500733 putative ATP binding protein 341342 RXA00878 GR 0024237331871 putative ABC transporter ATP binding protein 343344 RXN01191 VV 01691047812067 putative ABC transporter ATP binding protein 345346 FRXA01191 GR 003411571165 putative ABC transporter ATP binding protein 347348 RXN01212 VV 0169844207 putative ABC transporter ATP binding protein 349350 FRXA01212 GR 003501813 813 putative ABC transporter ATP binding protein 351352 RXA 00749 GR 4164535025025025028 putative ABC transporter ATP binding protein 353354 RXA02224 GR 006522271475 putative ABC transporter ATP binding protein 355356 RXN01602 VV 9110910938 putative ABC transporter ATP binding protein 357358 RXN 515 0202879617 putative ABC transporter ATP binding protein 359360 RXN0059 transferase binding protein 00735469 FWV 35469 FWV transferase mutein 9 RXN 35469 mutein 9 FWV transferase mutein 9 FWV 350049 FWV 35729 putative ABC transporter protein rxIV 35353535049 RXN 35569 ATC transferase mutein binding protein FWV 35569 RG GCWV transferase mutein binding protein VV 02262300726 spermidine/putrescine transporter ATP-binding protein POTA 373374 FRXA00368 GR 000761579 spermidine/putrescine transporter ATP-binding protein POTA 375376 FRXA00370 GR 000776803 spermidine/putrescine transporter ATP-binding protein POTA 377378 RXN01285 VV 021517801055 high-iron enterobacterin transporter ATP-binding protein FEPC 379380 RXN00523 VV 01936019363338 high-iron enterobacterin transporter PCEFG 381382 RXN01142 VV 00775563202 nitric acid transporter protein NRTD 383384 RXN01141 VV 007746445468 nitric acid transporter NRTA 385300486 RNX01002 VV 0106885855 phosphonic acid transporter protein PHNC 007010388N 010010676407 phosphonic acid transporter protein 03001047354705 RXN 030354705 transporter protein RXN 030010473547354705 RXN 030354705 binding protein FWV 030354705 precursor RXV 47354705 RXF

TABLE 1 (continuation) other transporters nucleic acid amino acid identification code contig NTStart NT termination function SEQ ID NO 393973398 RXA02261 GR 006543093632291 ammonium transporter system 339400 RXA02020 GR 0061310155 aromatic amino acid transporter AROP 401402 RXA00281 GR 0004347215404 bacitracin transporter ATP-RA 403404 RXN00570 VV 01478554 benzoate membrane transporter 405406 FRXA00570 GR 001531498 benzoate membrane transporter 407408 RXN00571 V0173129842 benzoate membrane transporter 409410 FRGR 00571 GR 0015421186 benzoate membrane transporter 411412A 962 00002GR 266867 benzoate membrane transporter 413414 RXGR 02811 GR 00792177560 benzoate membrane transporter 415416 RXGR GR 15 GR 02135006353521121198 benzoate membrane transporter rxN 0054 RXN 00501505050505050505701505050409A 0150004500049A 0150570049A codon 32353550579A transporter 37A codon 324705 F50579A transporter Acid transporter 429430 RXA00825 GR 0023131372448 cobalt transporter ATP binding protein CBIO 431432 RXA00690 GR 00181121368 cobalt transporter CBIQ 433434 RXA00827 GR 002231319567 cobalt transporter CBIQ 435436 RXA00851 GR 0023124481840 cobalt transporter CBIQ 437438 RXS 03220D-xylose proton symporter 439440 FRXA 62 GR 00746630D-xylose proton symporter 441442 RXN00092 VV 0127509844 glutamine transporter GLNQ 443444 FRXA00092 GR 000204 glutamine transporter ATP binding protein GLNQ 445446N 030062 275376 glutamine transporter ATP binding protein GLNQ 44447448 GR 02618 GR 0074519145351 ATP translocator GLNQ 924745351 ATP bindin GLNQ 009202900 GR 32924705 RXN dockerin glycoprotein RXO 35002453501045357420 RXN transporter protein RXN 00245350109 RXS 0109 RXN

Binding protein BRAG 461462 RXA01222 GR 0035428443542 homogenin and sex branched chain amino acid transport ATP

Binding protein LIVF 463464 RXA01219 GR 003541511032 high affinity branched chain amino acid transport permease

Protein LIVH

TABLE 1 (continuation) nucleic acid amino acid identification code contig NT Start NT termination function SEQ ID NO SEQ ID NO 465466 RXA01220 GR 0035410322108 high affinity branched chain amino acid transport permease

Protein LIVM 467468 RXA00091 GR 0001377628514 di-ferric citrate (III) transport ATP-binding protein FECE 469470 RXA00228 GR 000322923228642 di-ferric citrate (III) transport ATP-binding protein FECE 471472 RXA00346 GR 0006410541743 di-ferric citrate (III) transport ATP-binding protein FECE 473474 RXA00524 GR 001357791111 di-ferric citrate (III) transport ATP-binding protein FECE 47476 RXA01823 GR 005911367 di-ferric citrate (III) transport ATP-binding protein FECE 478 RXA 9480 GR 02767 GR 0077010321814 di-ferric citrate (III) transport ATP-binding protein FECE 479480 GR 00700700700792 GR 007007778178817829 di-ferric citrate (XA) transport protein FECE 474848489 RXVG 02923683874 92 RXA 5078 Fe-binding protein FECE 44489 CD0541924194 transport system FECG 45 CD 027 3270 Transporter II transporter (FECG 5335) transportprotein FECG 45 CD 16655 II transportprotein FECE 3270 CD05 Transporter III) transporter system FECG 704705 Transporter FRXA02865 GR 1000738322816 di-ferric citrate (III) transport system permease protein FECD 495496 RXA00181 GR 0002839542383 proline transport system 497498 RXA00591 GR 001582291581 proline/betaine transporter 499500 RXA01629 GR 00453761 34965 proline/betaine transporter 501502 RXA02030 GR 0061830727 proline/betaine transporter 503504 RXA00186 GR 000281224988 short chain transporter 505506 RXA00187 GR 000281309713447 short chain fatty acid transporter 5 01A 01004031908 sodium/glutamate symporter protein RXA 509510A 021004417119 sodium/proline symporter protein RXA00 511512A 00902 GR 002GR 465875 sodium dependent phosphate transporter 513514 RXA 0057199969 GR 360049 sodium dependent on sodium phosphate transporter ATP-binding protein POTA 525526 RXA02073 GR 00628417647 transport ATP-binding protein CYDC 527528 RXA01399 GR 0040911119 transport ATP-binding protein CYDD 529530 RXA01339 GR 0038984087164 tyrosine specific transporter 531532 RXA02527 GR 00725551968472-ketoglutarate/malate transporter precursor 533534 RXN00298 VV 01764022842072 high affinity choline transporter 535536 FRXA00298 GR 0004844596303 ectoine/proline/betaine vector ectoP

Table 1 (continuation) nucleic acid amino acid identification code contig NT start NT termination function SEQ ID NO 537538 RXA00596 GR 00159335787 potassium efflux systemin phaE 539540 RXA02364 GR 00686886841215C 4-dicarboxylic acid binding periplasmic protein precursor,

transporter 541542 RXN01411 VV 00502601526779 shikimate transporter 543544 RXN00960 VV 00751139105 proton/sodium-glutamate symporter 545546 RXN02447 VV 010714213203 galactose-proton symporter 547548 RXN02395 VV 01761674714858 betaine transporter BETP 549550 RXN02348 VV 0070277910 KUP system potassium uptake protein 551552 RXN00297 VV 0176763863039541 putative malonate transporter 553554 RXN03 VV 00708451087 glutamate binding protein precursor RXN02993 VV 007865 865 glutamine binding protein RXN031 007 557558 RXN 0033535353535653 putative trehalose transporter 559560 RXN 0300300595 VV 0057464424 calcium efflux system helper protein homolog 561562N 031 030025660 RXN 01569 VV014 VV 989 VV 365635569 protein Heterophyte repressor Kr 3502569 protein Heterophyte repressor preSv9202569 protein and RXN 03002569 protein HeterophytN 03002569 protein Heterophyte transporter VV 007727823 cation efflux system protein CZCD 577578 RXN00378 VV 0223805418 cation transport ATPase 579580 RXN01338 VV 003221903 cation transport ATPase PACS (EC 3.6.1.-) 581582 RXN00980 VV 014926354428 cation transport P type ATPase B (EC 3.6.1.-) 583584 RXN00099 VV 012917617704 cyanate transport protein CYNX 585586 RXN02662 VV 031514611724 dipeptide transport system permease protein DPPC 587588 RXN02442 VV 021759706818 zinc transport system membrane protein RXN02443 VV 021768187771 zinc binding periplasmic protein precursor RXN 00842N 00842 01386767673567353535353535353535353535353535350426 RXN 00353600353535019353535353535353535353535353535353535353535353535353535359 efflux protein PNPC VV 007363636363535353535353535353535353535353535353535353535353535353535353535353501926

TABLE 1 (continuation) permease nucleic acid amino acid identification code contig NT initiating NT termination function SEQ ID NO 605605606 RXN02566 VV 01541182313031 nucleoside permease NUPG 607608 FRXA02561 GR 007326645 nucleoside permease NUPG 609610 FRXA02566 GR 007332345 nucleoside permease NUPG 611612 RXA00051 GR 0000857773 proline specific permease PROY 613614 RXA GR 00334874141 sulfate permease 615616 RXA02128 GR 29064600 sulfate permease 026 617618 RXA02634 GR 00760457655 sulfate permease 619620 RXV 022 VV006810068142 uracil permease 621622 FRXA 022GR 5326 GR 006GR 53350635353535353535353535353535353535353502372 FQ 021 3113631197 xanthine 11131197 xanthine oxidase (+) -folate 0233113502397 Glycine folate diphosphate GCO 3502326 FQ 353535353535353535353535353535353535353535353535353535353535353535353535353535353535353535350426A APPA precursor (permease) 639640 RXN01382 VV 011986709761 oligopeptide-binding protein OPPA precursor 641642 FRXA01382 GR 0040510676 oligopeptide-binding protein OPPA precursor (permease) 643644 RXA02659 GR 007532313 oligopeptide-binding protein OPPA precursor (permease) 645646 RXN02933 VV 017630042233 dipeptide transporter DPPC 647648 RXN02991 VV 00726184 glutamine transporter protein GLNP 649650 RXN02992 VV 007422842621 glutamine transporter protein GLNP 651652N 02996 VV 006919 802648 high affinity branched chain amino acid transporter

Protein LIVH 653654 RXN03126 VV 011298949001 teichoic acid transport permease protein TAGG 655656 RXN00443 VV 01122157220769 molybdic acid binding to periplasmic protein precursor 657658 RXN00444 VV 01122078519949 molybdenum transport system permease protein MODB 659660 RXN00193 VV 03711594 potential starch degradation product transport system

Transpermease protein AMYD 661662 RXN01298 VV 011620711142 potential starch degradation product transport system

Permease protein AMYD

TABLE 1 (CONTINUOUS) CHANNEL PROTEIN NUCLEIC ACID IDENTIFICATION CODE GROUP ABSORBENT GROUP NT INITIATING NT TERMINATION FUNCTION SEQ ID NO 663664 RXA01737 GR 0049333971 Potassium CHANNEL PROTEIN 665666 RXN02348 VV 007860277910 KUP SYSTEM Potassium uptake protein 667668 RXA02426 GR 007072165633 possible NA (+)/H (+) vs. Transporter protein 669670 RX03164 VV 027715862455 Potassium channel β subunit 671672 RXN00024 VV 01276421963275 Potassium channel β subunit lipoprotein and lipopolysaccharide SYNTHESIS NUCLEIC ACID IDA IDS IDENTIFICATION IDS IDP mannosyltransferase (EC 2.4.1.83) ABSORBING NT INITIATION FUNCTION SRQ ID NO 673674N 01164 VV 01171589414260 POLYOL PHOSP

Apolipoprotein phosphate N-acyltransferase (EC 2.3.1.-) 675676 RXN01168 VV 01171422413415 dolichol phosphate mannosyltransferase (EC 2.4.1.83)&gt/in&lt/EN&gt

Apolipoprotein phosphate N-acyltransferase (EC 2.3.1.)

TABLE 2 excluded genes
	GenBankTM Registration number	Name of Gene	Gene function	Reference to the literature
A09073					ppg	Phosphoenolpyruvate carboxylase	Bachmann, B, et al "DNA fragments encoding phosphoenolpyruvate carboxylase, carrying said fragments The recombinant DNA of (1), a strain having the recombinant DNA, and a process for producing an L-amino acid using the strain Law ", patent: EP 0358940-A303/21/90
	A45579， A45581， A45583， A45585 A45587		Threonine dehydratase	Moeckel, B, et al, "production of L-isoleucine using recombinant microorganisms having deregulated threonine dehydratase Acid "patent: WO 9519442-A507/20/95
AB003132					murC；ftsQ；fisZ		Kobayashi, M. et al "cloning, sequencing and characterization of ftsZ Gene from coryneform bacteria" Biochem.Biophys.Res.Commun.，236(2)：383-388(1997)
	AB015023	murC；ftsQ		Wachi, M. et al, "MurC Gene from Corynebacterium," appl. Microbiol. Biotechnol., 51(2)：223-228(1999)
AB018530					dtsR		kimura, E.et al "rescue of mutant detergent sensitivity derived from Brevibacterium lactofermentum Molecular cloning of dtsR ", biosci.biotechnol.biochem., 60 (10): 1565-1570(1996)
	AB018531	dtsR1；dtsR2
AB020624					murI	D-glutamic acid racemase
	AB023377	tkt	Transhydroxyacetaldehyde enzyme
AB024708					gltB；gltD	Large subunit of glutamine 2-oxoglutarate aminotransferase And a small subunit
	AB025424	acn	Aconitase (Aconitum)
AB027714					rep	Replication proteins
	AB027715	rep；aad	A replication protein; aminoglycoside adenyl transferase
AF005242					argC	N-acetylglutamate-5-semialdehyde dehydrogenase
	AF005635	glnA	Glutamine synthetase
AF030405					hisF	Cyclases
	AF030520	argG	Argininosuccinate synthetase
AF031518					argF	Ornithine carbamoyltransferase
	AF036932	aroD	3-dehydroquinate dehydratase

Table 2 (continuation)
	AF038548	pyc	Pyruvate carboxylase
AF038651					dciAE；apt；rel	A dipeptide binding protein; adenine phosphoribosyl transferase; GTP pyrophosphokinase	Wehmeier, L., et al, "role of the rel gene of C.glutamicum in the metabolism of (p) ppGpp", Microbiology，144：1853-1862(1998)
	AF041436	argR	arginine repressor
AF045998					impA	Inositol monophosphate phosphatases
	AF048764	argH	Argininosuccinate lyase
AF049897					argC；argJ；argB； argD；argF；argR； argG；argH	N-acetylglutamyl phosphate reductase; ornithine acetyl group A transferase; n-acetylglutamate kinase; acetoornithine A transaminase; ornithine carbamoyltransferase; arginine inhibitor An aprotinin; argininosuccinate synthase; argininosuccinate lyase
	AF050109	inhA	Enoyl-acyl carrier protein reductases
AF050166					hisG	ATP phosphoribosyl transferase
	AF051846	hisA	Formyl imino-5-amino-1-phosphoribosyl-4-imidazoles Carboxamide nucleotide isomerase
AF052652					metA	Homoserine O-acetyltransferase	Park, S. et al "metA-A methionine encoding homoserine acetyltransferase in Corynebacterium glutamicum Isolation and analysis of genes for the biosynthesis of amino acids ", mol.cells., 8 (3): 286-294(1998)
	AF053071	aroB	Dehydroquinic acid synthetase
AF060558					hisH	Transglutaminase
	AF086704	hisE	phosphoribosyl-ATP-pyrophosphate hydrolase
AF114233					aroA	5-enolpyruvylshikimate 3-phosphate synthase
	AF116184	panD	L-aspartic acid- α -decarboxylase precursor	Dusch, N.et al "expression of the panD Gene of Corynebacterium glutamicum coding for L-aspartate- α -decarboxylase Leading to an overproduction of pantothenic acid ", Ap, in E.colipl.Environ.Microbiol.，65(4)1530-1539 (1999)
AF124518					aroD；aroE	3-dehydroquinase (dehydroquinase); shikimic acid Deaminase
	AF124600	aroC；aroK；aroB； pepQ	A chorismate synthase; a shikimate kinase; 3-dehydroquinic acid A synthase; putative cytoplasmic peptidases

Table 2 (continuation)
	AF145897	inhA
AF145898					inhA
	AJ001436	ectP	Transport of ectoine, betaine and proline	Peter, h, et al, "corynebacterium glutamicum is provided with four second vectors matching solutes: proline/ectoine uptake Identification, sequencing and characterization of the system-entry ProP and ectoine/proline/betaine vector EctP ", J. Bacteriol.，180(22)：6005-6012(1998)
AJ004934					dapD	Tetrahydro-2, 6-pyridinedicarboxylic acid succinylase (incomplete) Is/are as followsi)	Wehrmann, A. et al "Synthesis of diaminopimelic acidAnd their pattern of differentiation in cell wall integrity The function is as follows: study with corynebacterium glutamicum ", j. bacteriol., 180 (12): 3159-3165(1998)
	AJ007732	ppc；secG；amt；ocd； soxA	Phosphoenolpyruvate carboxylase; is there a (ii) a High affinity ammonium Ingesting a protein; a putative ornithine-cyclodecarboxylase; muscle Ammonia acid oxidase
AJ010319					ftsY，glrB，glnD；srp； amtP	(ii) involved in cell division; a PH protein; uridine acyl transfer Enzymes (uridylyl-releasing enzymes); the signal identifies the particle; is low in Affinity ammonium uptake proteins	Jakoby, m. et al "nitrogen regulation in c.glutamicum; involving biochemical identification of the corresponding protein The isolation of the gene of (a), "femmichobiol, 173 (2); 303-310(1999)
	AJ132968	cat	Chloramphenicol acetyltransferase
AJ224946					mqo	L-malic acid; quinone oxidoreductase	Molenaar, D.et al "biochemistry of Membrane-associated malate dehydrogenase (receptor) from Corynebacterium glutamicum And genetic characterization ", eur.j.biochem., 254 (2): 395-403(1998)
	AJ238250	ndh	NADH dehydrogenase
AJ238703					porA	Membrane pore proteins	Lichtinger, T, et al, "biochemical and biophysical characterization of cell wall porins of Corynebacterium glutamicum And (4) identification: the channel is formed by a low molecular weight polypeptide ", Biochemistry，37(43)：15024-15032 (1998)
	D17429		Transposable element IS31831	Vertes et al "isolation and characterization of transposable element IS31831 from Corynebacterium glutamicum", Mol. Microbiol.，11(4)：739-746(1994)
D84102					odhA	2-ketoglutarate dehydrogenase	Usuda, Y, et al "Corynebacterium glutamicum encoding a novel 2-oxoglutarate dehydrogenase (Brevibacterium lactofermentum) AJ12036) molecular cloning of the odhA gene ", Microbiology, 142: 3347-3354(1996)
	E01358	hdh；hk	Homoserine dehydrogenase; homoserine kinase	Katsumata, R. et al "production of L-threonine and L-isoleucine", patent: JP 1987232392-A 1 10/12/87
E01359						Homoserine kinase gene start codon upstream	Katsumata, R. et al "production of L-threonine and L-isoleucine", patent: JP 1987232392-A2 10/12/87
	E01375		Tryptophan operon
E01376					trpL；trpE	A leader peptide; anthranilate synthase	Matsui, K. et al "Tryptophan operon, peptides and proteins encoded thereby, Tryptophan operon genes Utilization of expression and production of tryptophan ", patents: JP 1987244382-A110/24/87

Table 2 (continuation)
	E01377		Promoter and operator regions of the tryptophan operon	Matsui, K. et al "Tryptophan operon, peptides and proteins encoded thereby, Tryptophan operon genes Utilization of expression and production of tryptophan ", patents: JP 1987244382-A110/24/87
E03937						Biotin synthases	Hatakeyama, K. et al "DNA fragment containing gene capable of encoding biotin synthase and use thereof", the patent: JP 1992278088-A110/02/92
	E04040		Diaminononanoic acid aminotransferase	Kohama, K, et al "genes encoding diaminononanoic acid aminotransferase and desthiobiotin synthase and methods of use thereof Application ", patent: JP 1992330284-A111/18/92
E04041						Desulfurized biotin synthase	Kohama, K, et al "genes encoding diaminononanoic acid aminotransferase and desthiobiotin synthase and methods of use thereof Application ", patent: JP 1992330284-A111/18/92
	E04307		Flavum aspartase	Kurusu, y, et al, "gene DNA encoding aspartase and uses thereof", patents: JP 1993030977-A 1 02/09/93
E04376						Isocitrate lyase	Katsumata, R. et al, "Gene expression controlling DNA", patent: JP 1993056782-A303/09/93
	E04377		N-terminal fragment of isocitrate lyase	Katamuata, r, et al, "gene expression controlling DNA", patents: JP 1993056782-A303/09/93
E04484						Prephenate dehydratase	Sotouchi, N et al, "L-phenylalanine production by fermentation", patent: JP 1993076352-A2 03/30/97
	E05108		Aspartokinase	Fugono, n, et al, "gene DNA encoding aspartokinase and uses thereof", patent: JP 993184366-A 1 07/27/93
E05112						Dihydro-dipichorinate synthetase	Hatakeyama, K. et al, "DNA of gene encoding dihydro2, 6-dipicolinate synthetase and use thereof", the patent: JP 1993184371-A107/27/93
	E05776		Diaminopimelate dehydrogenase	Kobayashi, M. et al, "DNA of a Gene encoding diaminopimelate dehydrogenase and uses thereof", patent: JP 1993284970-A 1 11/02/93
E05779						threonine synthase	Kohama, K, et al, "threonine synthase-encoding gene DNA and uses thereof", patent: JP 1993284972-A 1 11/02/93
	E06110		Prephenate dehydratase	Kikuchi, T, et al, "L-phenylalanine production by fermentation", patents: JP 1993344881-A1 12/27/93
E06111						Mutant prephenate dehydratases	Kikuchi, T, et al, "L-phenylalanine production by fermentation", patents: JP 1993344881-A1 12/27/93
	E06146		Acetohydroxy acid synthetase	Inui, m. et al, "genes encoding acetohydroxyacid synthases and uses thereof", patents: JP 1993344893-A 1 12/27/93
E06825						Aspartokinase	Sugimoto, M. et al, "mutant aspartokinase gene", patent: JP 1994062866-A1 03/08/94
	E06826		Mutant aspartokinase α subunit	Sugimoto, M. et al, "mutant aspartokinase gene", patent: JP 1994062866-A1

			03/08/94

Table 2 (continuation)
	E06827		Mutant aspartokinase α subunit	Sugimoto, M. et al, "mutant aspartokinase gene", patent: JP 1994062866-A1 03/08/94
E07701					secY		Honno, n, et al, "DNA of genes involved in integration of membrane proteins with membranes", patent: JP 1994169780-A1 06/21/94
	E08177		Aspartokinase	Sato, Y, et al "Gene DNA capable of encoding aspartokinase released from feedback inhibition and use thereof Use ", patent: JP 1994261766-A109/20/94
E08178， E08179， E08180， E08181， E08182						Feedback inhibition released aspartokinase	Sato, Y, et al "Gene DNA capable of encoding aspartokinase released from feedback inhibition and use thereof Use ", patent: JP 1994261766-A109/20/94
	E08232		Acetohydroxy acid isomeroreductase	Inui, M. et al, "Gene DNA encoding acetohydroxy acid isomeroreductase", patent: JP 1994277067-A 1 10/04/94
E08234					secE		Asai, y, et al, "gene DNA encoding protein transport machinery", patent: JP 1994277073-A1 10/04/94
	E08643		FT aminotransferase and desthiobiotin synthase priming Sub-region	Hatakeyama, K. et al "DNA fragment having promoter function in coryneform bacteria", patent: JP 1995031476-A 1 02/03/95
E08646						Biotin synthetase	Hatakeyama, K. et al "DNA fragment having promoter function in coryneform bacteria", patent: JP 1995031476-A 1 02/03/95
	E08649		Aspartase	Kohama, K.et al, "DNA fragments having promoter function in coryneform bacteria", patent: JP 1995031478-A 1 02/03/95
E08900						Dihydro 2, 6-pyridinedicarboxylic acid reductase	Madori, M, et al "DNA fragment containing gene encoding dihydro-2, 6-pyridinedicarboxylic acid reductase and its Application ", patent: JP 1995075578-A103/20/95
	E08901		Diaminopimelic acid decarboxylase	Madori, M. et al, "DNA fragment containing gene encoding diaminopimelate decarboxylase and use thereof", the patent: JP 1995075579-A103/20/95
E12594						Serine hydroxymethyltransferase	Hatakeyama, K. et al, "production of L-tryptophan", patent: JP 1997028391-A102/04/97
	E12760， E12759， E12758		Transposase	Moriya, m. et al, "gene amplification using artificial transposons", patents: JP 1997070291-A03/18/97
E12764						arginyl-tRNA synthetase; diamino radicalDecarboxylation of pimelic acid Enzyme	Moriya, m. et al, "gene amplification using artificial transposons", patents: JP 1997070291-A03/18/97
	E12767		Dihydro 2, 6-dipicolinate synthetase	Moriya, m. et al, "gene amplification using artificial transposons", patents: JP 1997070291-A03/18/97

Table 2 (continuation)
	E12770		Aspartokinase	Moriya, m. et al, "gene amplification using artificial transposons", patents: JP 1997070291-A03/18/97
E12773						Dihydro 2, 6-pyridinedicarboxylic acid reductase	Morlya, m. et al, "gene amplification using artificial transposon", patent: JP 1997070291-A03/18/97
	E13655		Glucose-6-phosphate dehydrogenase	Hatakeyama, K. et al, "glucose-6-phosphate dehydrogenase and DNA capable of encoding the same", patent: JP 1997224661-A 1 09/02/97
L01508					IlvA	threonine dehydratase	Moeckel, b. et al, "functional and structural analysis of threonine dehydratase from c.glutamicum", j.bacteriol, 174：8065-8072(1992)
	L07603	EC 4.2.1.15	3-deoxy-D-arabinoheptulosonate-7-phosphate synthase	Chen, C, et al, "cloning of Corynebacterium glutamicum 3-deoxy-D-arabinoheptulosonate-7-phosphate synthase Gene And nucleotide sequence ", femmichobiol.lett., 107: 223-230(1993)
L09232					IlvB；ilvN；ilvC	Acetohydroxyacid synthase large subunit; acetohydroxyacid synthase small subunit; acetohydroxy acid isomeroreductase	Keilhauer, C. et al "isoleucine synthesis in C.glutamicum: of the ilvB-ilvN-ilvC operon Molecular analysis ", j. bacteriol, 175 (17): 5595-5603(1993)
	L18874	PtsM	Phosphoenolpyruvate sugar phosphotransferase	Fouet, A et al, "sucrose-specific enzyme II of the Bacillus subtilis phosphotransferase System: in Escherichia coli Expression and homology to enzyme II from enterobacteria ", PNAS USA, 84 (24): 8773-8777 (1987) (ii) a Lee, J.K., et al "nucleotide sequence of the Gene encoding Corynebacterium glutamicum mannosidase II and analysis of the deduced protein sequence ", femmichobiol.lett., 119 (1-2): 137-145(1994)
L27123					aceB	Malate synthase	Lee, H-S, et al "aceB-molecular characterization of the Gene encoding malate synthase in Corynebacterium glutamicum Identification ", j.microbiol.biotechnol., 4 (4): 256-263(1994)
	L27126		Pyruvate kinase	Jetten, M.S. et al, "structural and functional analysis of pyruvate kinase from Corynebacterium glutamicum", Appl. Environ.Microbiol.，60(7)：2501-2507(1994)
L28760					aceA	Isocitrate lyase
	L35906	dtxr	Diphtheria toxin repressor protein	Oguiza, JA. et al "molecular cloning, DNA sequence of c.diphtheriae dtxR from Brevibacterium lactofermentum Column analysis and characterization ", j. bacteriol, 177 (2): 465-467(1995)
M13774						Prephenate dehydratase	Follettie, M.T., et al, "molecular cloning and nucleotide sequence of the pheA gene of Corynebacterium glutamicum", J. Bacteriol.，167：695-702(1986)
	M16175	5S rRNA		Park, Y-H, et al, "phylogenetic analysis of coryneform bacteria by 56 rRNA sequences", J. Bacteriol.，169：1801-1806(1987)
M16663					trpE	Anthranilate synthase, 5' terminal	Sano, K. et al "A glutamic acid-producing bacterium-Structure of trp operon of Brevibacterium lactofermentum and function ", Gene, 52: 191-200(1987)
	M16664	trpA	Tryptophan synthase, 3' end	Sano, K. et al "A glutamic acid-producing bacterium-Structure of trp operon of Brevibacterium lactofermentum and function ", Gene, 52: 191-200(1987)

Table 2 (continuation)
	M258l9		Phosphoenolpyruvate carboxylase	O' Regan, M. et al "coding group for phosphoenolpyruvate carboxylase of Corynebacterium glutamicum ATCC13032 Cloning and nucleotide sequence of genes ", Gene, 77 (2): 237-251(1989)
M85106						23S rRNA gene insertion sequence	Roller, C.et al "gram-positive bacteria with high DNAG + C content are characterized by 23S A co-insertion within the rRNA gene ", j.gen.microbiol., 138: 1167-1175(1992)
	M85107， M85108		23S rRNA gene insertion sequence	Roller, C.et al "gram-positive bacteria with high DNAG + C content are characterized by 23S A co-insertion within the rRNA gene ", j.gen.microbiol., 138: 1167-1175(1992)
M89931					aecD；brnQ；yhbw	β C-S lyase, branched chain amino acid uptake vectors, pseudopeptides Protein yhbw of origin	Rossol, I.et al "Corynebacterium glutamicum aecD Gene encoding a polypeptide having the ability to degrade aminoethylcysteine α -C-S lyase which eliminates activity ", J.Bacteriol.174 (9): 2968-2977 (1992); Tauch, A. et al "isoleucine uptake in Corynebacterium glutamicum ATCC13032 is guided by the brnQ gene product", Arch.Microbiol.，169(4)：303-312(1998)
	S59299	trp	leader Gene (promoter)	Herry, D.M. et al "cloning of the trp gene cluster from a tryptophan-producing strain of Corynebacterium glutamicum: trP identification of a mutation in the leader sequence, appl. environ. microbiol, 59 (3): 791-799 (1993)
U11545					trpD	Anthranilic acid phosphoribosyltransferase	O' Gara, J.P. and Dunican, L.K. (1994) "of Corynebacterium glutamicum ATCC 21850 tpD Gene Complete nucleotide sequence ", thesis, Microbiology Department, University College galvay, Ireland
	U13922	cglIM；cglIR；clgIIR	a putative type II 5-cytosine methyltransferase; estimation of Type II restriction endonucleases of (1); putative type I or Type III restriction endonucleases	Schafer, A. et al "restriction System from Corynebacterium glutamicum ATCC13032 encoding stress sensitivity Cloning and characterization of the DNA region of (A) and its role in intergeneric conjugation with E.coli Assay ", j. bacteriol.176 (23): 7309 and 7319 (1994); schafer, A. et al, "Corynebacterium glutamicum The cglIM Gene coding for 5-cytosine in McrBC deficient E.coli strains, Gene, 203(2)：95-101(1997)
U14965					recA
	U31224	ppx		ankri, s. et al "mutations in the proline biosynthetic pathway of c.glutamicum: nature of the proA step Bypass ", j. bacteriol, 178 (15): 4412-4419(1996)
U31225					proC	L-proline: NADP + 5-oxidoreductase	Ankri, s. et al "mutations in the proline biosynthetic pathway of c.glutamicum: nature of the proA step Bypass ", j. bacteriol, 178 (15): 4412-4419(1996)
	U31230	obg；proB；unkdh	Is there a (ii) a Gamma-glutamyl kinase; specific for D-isomer 2-hydroxy acid dehydrogenases are similar	Ankri, s. et al "mutations in the proline biosynthetic pathway of c.glutamicum: nature of the proA step Bypass ", j. bacteriol, 178 (15): 4412-4419(1996)

Table 2 (continuation)
	U31281	bioB	Biotin synthases	Serebriiskii, i.g. "two new members of the bioB superfamily: methylobacillus flagellatum and cloning, sequencing and expression of the bio B Gene of c.glutamicum ", Gene, 175: 15-22(1996)
U35023					thtR；accBC	A thiosulfatothiotransferase; acyl CoA carboxylase	Jager, W, et al "encode a subdomain protein similar to biotin carboxylase and biotin carboxyl carrier proteins Corynebacterium glutamicum gene of white, Arch. Microbiol.，166(2)；76-82(1996)
	U43535	cmr	Multi-drug resistance proteins	Jager, W. et al "Corynebacterium glutamicum genes conferring multiple drug resistance in heterologous host E.coli Thus ", j. bacteriol, 179 (7): 2449-2451(1997)
U43536					clpB	Heat shock ATP-binding proteins
	U53587	aphA-3	3' 5 "-aminoglycoside phosphotransferase
U89648						Method for the biosynthesis of histidine in Corynebacterium glutamicum Unidentified sequence, partial sequence
	X04960	trpA；trpB；trpC；trpD； TrpE；trpG，trpL	Tryptophan operon	Matsui, K. et al, "complete nucleotide sequence and deduced amino acid of tryptophan operon of Brevibacterium lactofermentum Sequence "Nucleic Acids res, 14 (24): 10113-10114(1986)
X07563					lysA	DAP decarboxylase (meso-diaminopimelate decarboxylase, EC 4.1.1.20)	yeh, P, et al "nucleic acid sequence of lysA Gene of Corynebacterium glutamicum and possibility of regulating expression thereof System ", mol.gen.genet., 212 (1): 112-119(1988)
	X14234	EC 4.1.1.31	Phosphoenolpyruvate carboxylase	Eikmanns, B J. et al "phosphoenolpyruvate carboxylase gene of Corynebacterium glutamicum: molecular cloning, Nucleotide sequence and expression ", mol.gen.genet., 218 (2): 330-; lepinie, L "sorghum phosphoenolpyruvate carboxylase gene family: structure, function and molecular evolution ", Plant. Mol.Biol.，21(3)：487-502(1993)
X17313					fda	Fructose bisphosphate aldolase	Molecular cloning, nucleotide sequence and essence of the Fda Gene of Corynebacterium glutamicum, Von der Osten, C.H Fine structure analysis: conjugation of C.glutamicum fructose-1, 6-bisphosphate aldolase with class I and class II aldolases Structure comparison ", mol. Microbiol.,
	X53993	dapA	l-2, 3-dihydro-2, 6-dipicolinate synthase (EC 4.2.1.52)	Bonnassie, S. et al "Nucleic acid sequence of dapA Gene from Corynebacterium glutamicum", Nucleic Acids Res.，18(21)：6421(1990)
X54223						AttB-related sites	Ciancetoto, N.et al "Corynebacterium diphtheriae, Corynebacterium ulcerans (Corynebacterium ulcerans) and Glutamine Homology of DNA sequences between att B-related sites of Corynebacterium acidocaldarium and attP sites of bacteriophage lambda of Corynebacterium Sex ", FEMS, Microbiol, lett, 66: 299-302(1990)
	X54740	argS；lysA	arginyl-tRNA synthetase; decarboxylation of diaminopimelic acid Enzyme	Marcel, T.et al "nucleotide sequence and organization of the upstream region of the lysA gene of Corynebacterium glutamicum", Mol. Microbiol.，4(11)：1819-1830(1990)

Table 2 (continuation)
	X55994	trpL；trpE	A putative leader peptide; anthranilate synthase component I	Heery, D.M. et al, "nucleotide sequence of the trpE gene of Corynebacterium glutamicum", Nucleic Acids Res., 18(23)：7138(1990)
X56037					thrC	threonine synthase	Han, K.S., et al, "molecular Structure of threonine synthase Gene of Corynebacterium glutamicum", mol.Microbiol, 4(10)：1693-1702(1990)
	X56075	attB-related sites	Attachment sites	Ciancetoto, N.et al "Corynebacterium diphtheriae, Corynebacterium ulcerans (Corynebacterium ulcerans) and Glutamine Homology of DNA sequences between attB-related sites of Corynebacterium acidocaldarium and attP sites of bacteriophage Lambda Sex ", fems. microbiol, lett, 66: 299-302(1990)
X57226					lysC-α；lysC-β； asd	Aspartokinase α subunit; aspartokinase β subunit, aspartic acid β semialdehyde Catalase enzyme	Kalinowski, J. et al "genetic and biochemical scoring of aspartokinase from Corynebacterium glutamicum Assay ", mol. Microbiol., 5 (5): 1197-; kalinowski, J. et al "aspartokinase The genes lysC α and lysC β overlap and react with the aspartate β semialdehyde dehydrogenase group in Corynebacterium glutamicum Because asd is adjacent, "mol.gen.gene., 224 (3): 317-324(1990)
	X59403	gap；pgk；tpi	Glyceraldehyde-3-phosphate; phosphoglycerate kinase; triose phosphate isomerase	Eikmanns, B.J. "A code for three glycolytic enzymes glyceraldehyde-3-phosphate dehydrogenase, phosphoglycerate Identification, sequence analysis and expression of the Corynebacterium glutamicum gene cluster of kinases and triose phosphate isomerase ", J.Bacteriol.，174(19)：6076-6086(1992)
X59404					gdh	glutamate dehydrogenase	Bormann, E.R., et al, "molecular analysis of the gdh gene of Corynebacterium glutamicum coding for glutamate dehydrogenase", Mol.Microbiol.，6(3)：317-326(1992)
	X60312	Lysl	l-lysine permease	Seep-Feldhaus, A.H. et al "molecular division of the lysl Gene of Corynebacterium glutamicum involved in lysine uptake Assay ", mol. Microbiol., 5 (12): 2995-3005(1991)
X66078					Copl	Psl protein	Joliff, G, et al "encoding the csp1 gene of PS1, one of the two major secreted proteins of C.glutamicum Cloning and nucleotide sequence: the deduced N-terminal region of PS1 complexed with Mycobacterium antigen 85 Similarly, "mol. Microbiol., 6 (16): 2349-2362(1992)
	X66112	glt	Citrate synthase	Eikmanns, B.J. et al "cloning sequence of gltA Gene of Corynebacterium glutamicum encoding citrate synthase, Expression and transcription analysis ", microbiol, 140: 1817-1828(1994)
X67737					dapB	Dihydro 2, 6-pyridinedicarboxylic acid reductase
	X69103	csp2	S-layer protein PS2	Peyret, J.L., et al, "Special features of the cspB gene encoding an ordered S-layer protein PS2 in Corynebacterium glutamicum Characterization ", mol. microbiol, 9 (1): 97-109(1993)
X69104						IS3 related insertion element	Bonamy, C.et al "identification of an insertion sequence IS 1206 related to Corynebacterium glutamicum IS3 and germline Occurrence assay ", mol. microbiol, 14 (3): 571-581(1994)

Table 2 (continuation)
	X70959	leuA	Isopropylmalate synthase	Patek, m. et al "leucine synthesis in corynebacterium glutamicum: enzymatic activity and structure of leuA, and leuA Effect of inactivation on lysine synthesis ", appl.environ.microbiol., 60 (1): 133-140(1994)
X71489					icd	Isocitrate dehydrogenase (NADP +)	Eikmanns, B.J., et al, "cloning sequences of the icd Gene of Corynebacterium glutamicum coding for isocitrate dehydrogenase Analysis, expression and inactivation, and biochemical characterization of the enzyme ", j. bacteriol, 177 (3): 774-782 (1995)
	X72855	GDHA	Glutamate dehydrogenase (NADP +)
X75083， X70584					mtrA	Resistance to 5-methyltryptophan	Heery, DM. et al, "Tryptophan high-producing strains from Corynebacterium glutamicum code for resistance to 5-methyltryptophan The sequence of (1) ", biochem. biophysis. res. commun., 201 (3): 1255-1262(1994)
	X75085	recA		Fitzpatrick, R. et al "construction and characterization of recA mutants of Corynebacterium glutamicum and Brevibacterium lactofermentum Identification ", appl.microbiol.biotechnol, 42 (4): 575-580(1994)
X75504					aceA；thiX	A portion of isocitrate lyase; is there a	Reinscheid, D.J., et al "characterization of the isocitrate lyase Gene from Corynebacterium glutamicum to And biochemical analysis of the enzyme, j. bacteriol, 176 (12): 3474-3483(1994)
	X76875		ATPase β subunit	Ludwig, W.et al, "details based on comparative sequence analysis of elongation factor Tu and ATP synthase β subunit genes Strain phylogenetic relationship, "Antonie Van leewenhoek, 64: 285-305(1993)
X77034					tuf	Elongation factor Tu	Ludwig, W.et al, "details based on comparative sequence analysis of elongation factor Tu and ATP synthase β subunit genes Strain phylogenetic relationship, "Antonie Van leewenhoek, 64: 285-305(1993)
	X77384	recA		Billman-Jacobe, H. "nucleotide sequence of recA gene from Corynebacterium glutamicum", DNA Seq.，4(6)：403-404(1994)
X78491					aceB	Malate synthase	Reinscheid, D.J., et al, "from the pta-ack operon of Corynebacterium glutamicum encoding phosphotransacetylase The malate synthase of (1): sequence analysis ", Microbiology, 140: 3099-3108(1994)
	X80629	16S rDNA	16S ribosomal RNA	Rainey, F.A., et al, "phylogeny of Rhodococcus (Rhodococcus) and Nocardia (Norcardia) Analysis and evidence of the evolutionary origin of nocardia from rhodococcus radiation ", microbiol, 141：523-528(1995)
X81191					gluA；gluB；gluC； gluD	glutamic acid uptake system	Kronemeyer, W.et al "knot encoding the gluABCD cluster of C.glutamicum glutamate uptake System Structure ", j. bacteriol, 177 (5): 1152-1158(1995)
	X81379	dapE	Succinyldiaminopimelate desuccinylase	Wehuman, A. et al "division of different DNA fragments of Corynebacterium glutamicum complementary to dapE of Escherichia coli Analysis ", Microbiology, 40: 3349-56(1994)

Table 2 (continuation)
	X82061	16S rDNA	16S ribosomal RNA	Ruimy, R.et al "phylogeny of Corynebacterium deduced from analysis of the sequence of the small subunit ribosomal DNA", Int.J.Syst.Bacteriol.，45(4)：740-746(1995)
X82928					asd；lysC	aspartate semialdehyde dehydrogenase; is there a	Serebrijski, I. et al "multiple copy inhibition by asd Gene and by heterologous proA in proA mutants Caused osmotic stress-dependent complementation ", j. bacteriol, 177 (24): 7255-7260(1995)
	X82929	proA	Gamma-glutamyl phosphate reductase	Serebrijski, I. et al "multiple copy inhibition by asd Gene and by heterologous proA in proA mutants Caused osmotic stress-dependent complementation ", j. bacteriol, 177 (24): 7255-7260(1995)
X84257					16S rDNA	16S ribosomal RNA	Pascual, C.et al, "phylogenetic analysis of Corynebacterium based on 16SrRNA gene sequences", Int. J.Syst.Bacteriol，45(4)：724-728(1995)
	X85965	aroP；dapE	An aromatic amino acid permease; is there a	Functional analysis of the adjacent sequences of "Corynebacterium glutamicum proline dapE" by Wehrmann et al revealed that Presence of aroP of family amino acid transporters ", j. bacteriol, 177 (20): 5991-5993(1995)
X86157					argB；argC；argD； argF；argJ	Acetyl glutamate kinase; n-acetyl-gamma-glutamyl phosphate A proenzyme; acetyl ornithine aminotransferase; ornithine carbamoylation Transferring enzyme; glutamic acid N-acetyltransferases	Sakanyan, V. et al "genes and enzymes of acetyl cycle biosynthesis by arginine in Corynebacterium glutamicum: enzyme evolution in the early steps of the arginine pathway, "Microbiology, 142: 99-108(1996)
	X89084	pta；aekA	A phosphate acetyltransferase; acetate kinase	Reinscheid, D.J., et al, "Corynebacterium glutamicum pta-ack encoding phosphotransacetylase and acetate kinase Cloning, sequence analysis, expression and inactivation of operons ", Microbiology, 145: 503-513(1999)
X89850					attB	Attachment sites	Le Marrec, C.et al phi AAU2 "infected" with Arthrobacter aureofaciens (Arthrobacter aureus) C70 Genetic characterization of site-directed integration functions ", j. bacteriol, 178 (7): 1996-2004(1996)
	X90356		Promoter fragment F1	Patek, M. et al "promoter from C.glutamicum: cloning, molecular analysis and search for consensus motifs Cable ", Microbiology, 142: 1297-1309(1996)
X90357						Promoter fragment F2	Patek, M. et al "promoter from C.glutamicum: cloning, molecular analysis and search for consensus motifs Cord 1 ", Microbiology, 142: 1297-1309(1996)
	X90358		Promoter fragment F10	Patek, M. et al "promoter from C.glutamicum: cloning, molecular characterizationAnalysis and search of consensus motifs Cable ", Microbiology, 142: 1297-1309(1996)
X90359						Promoter fragment F13	Patek, M. et al "promoter from C.glutamicum: cloning, molecular analysis and search for consensus motifs Cable ", Microbiology, 142: 1297-1309(1996)

Table 2 (continuation)
	X90360		Promoter fragment F22	Patek, M. et al "promoter from C.glutamicum: cloning, molecular analysis and search for consensus motifs Cable ", Microbiology, 142: 1297-1309(1996)
X90361						Promoter fragment F34	Patek, M. et al "promoter from C.glutamicum: cloning, molecular analysis and search for consensus motifs Cable ", Microbiology, 142: 1297-1309(1996)
	X90362		Promoter fragment F37	Patek, M. et al "promoter from C.glutamicum: cloning, molecular analysis and search for consensus motifs Cable ", Microbiology, 142: 1297-1309(1996)
X90363						Promoter fragment F45	Patek, M. et al "promoter from C.glutamicum: keke (Chinese character of 'Keke')Cloning, molecular analysis and search for consensus motifs Cable ", Microbiology, 142: 1297-1309(1996)
	X90364		Promoter fragment F64	Patek, M. et al "promoter from C.glutamicum: cloning, molecular analysis and search for consensus motifs Cable ", Microbiology, 142: 1297-1309(1996)
X90365						Promoter fragment F75	Patek, M. et al "promoter from C.glutamicum: cloning, molecular analysis and search for consensus motifs Cable ", Microbiology, 142: 1297-1309(1996)
	X90366		Promoter fragment PF101	Patek, M. et al "promoter from C.glutamicum: cloning, molecular analysis and search for consensus motifs Cable ", Microbiology, 142: 1297-1309(1996)
X90367						Promoter fragment PF104	Patek, M. et al "promoter from C.glutamicum: cloning, molecular analysis and search for consensus motifs Cable ", Microbiology, 142: 1297-1309(1996)
	X90368		Promoter fragment PF109	Patek, M. et al "promoter from C.glutamicum: cloning, molecular analysis and search for consensus motifs Cable ", Microbiology, 142: 1297-1309(1996)
X93513					amt	Ammonium transfer system	Siewe, r.m. et al "functional and genetic characterization of the uptake of ammonium by corynebacterium glutamicum (methyl) into vectors", J. Biol.Chem.，271(10)：5398-5403(1996)
	X93514	betP	Betaine transport system	Peter, H, et al, "isolation of beta P Gene from Corynebacterium glutamicum encoding a matched solute betaine transport System, Characterization and expression ", j. bacteriol, 178 (17): 5229-5234(1996)
X95649					orf4		Patek, M.et al "Corynebacterium glutamicum dapB-ORF2 encoding two enzymes involved in L-lysine synthesis- Identification and transcriptional analysis of the dapA-ORF4 operon ", biotechnol.lett., 19: 1113-1117 (1997)
	X96471	lysE；lysG	A lysine exporter protein; lysine export regulatory protein	Vrljic, m, et al "a new class of transporters with a new class of cellular functions: from Corynebacterium glutamicum L-lysine export ", mol. microbiol, 22 (5): 815-826(1996)

Table 2 (continuation)
	X96580	panB；panC；xylB	3-methyl-2-ketobutyrate hydroxymethyltransferase; pantoic acid- β -alanine ligase, xylulokinase	Sahm, H.et al "D-pantothenic acid Synthesis in Corynebacterium glutamicum and Synthesis of panBC and the coding L-valine The resulting gene was used for overproduction of D-pantothenic acid ", appl. environ. Microbiol, 65(5)：1973-1979(1999)
X96962						insertion sequence IS1207 and transposase
	X99289		Elongation factor P	Ramos, A. et al "encoding amino acid producing bacterium Brevibacterium lactofermentum (Corynebacterium glutamicum ATCC 13869) Cloning, sequencing and expression of the Gene for elongation factor P ", Gene, 198: 217-222(1997)
Y00140					thrB	Homoserine kinase	Mateos, L.M. et al, "nucleotide sequence of homoserine kinase (thrB) gene of Brevibacterium lactofermentum", NucleicAcids Res.，15(9)：3922(1987)
	Y00151	ddh	meso-diaminopimelate D-dehydrogenase (EC 1.4.1.16)	Ishino, S et al "nucleotides of the Medium-Diaminopimelate D-dehydrogenase Gene from Corynebacterium glutamicum Sequence "nucleoicacidsres, 15 (9): 3917(1987)
Y00476					thrA	Homoserine dehydrogenase	Mateos, L.M. et al "nucleotide sequence of homoserine dehydrogenase (thrA) gene of Brevibacterium lactofermentum", Nucleic Acids Res.，15(24)10598(1987)
	Y00546	hom；thrB	homoserine dehydrogenase; homoserine kinase	Nucleotide sequence and Fine Structure of the Phom-thrB operon of Corynebacterium glutamicum, et al, Peoples, O.P Assay ", mol. Microbiol., 2 (1): 63-72(1988)
Y08964					murC；ftsQ/divD；ftsZ	UPD-N-acetyl cell wallAcid-alanine ligase; splitting of A starting protein or a cell division protein; cell division proteins	Identification, characterization and staining of the ftsZ Gene from Brevibacterium lactofermentum, Horrubia, M.P., et al Body organization ", mol.gen.genet., 259 (1): 97-104(1998)
	Y09163	putP	High affinity proline transport systems	Peter, H, et al, "isolation of the PutP Gene for proline in Corynebacterium glutamicum and Low affinity matching of solutes Characterization of the uptake system ", arch. microbiol., 168 (2): 143-151(1997)
Y09548					pyc	Pyruvate carboxylase	Peters-Wendisch, P.G. et al "pyruvate carboxylase from Corynebacterium glutamicum: features of the pyc gene Characterization, expression and inactivation ", Microbiology, 144: 915-927(1998)
	Y09578	leuB	3-isopropylmalate dehydrogenase	Patek, M. et al, "analysis of the leuB gene from C.glutamicum", appl. Microbiol, Biotechnol.，50(1)：42-47(1998)
Y12472						attachment site phage Phi-16	Moreau, S et al "site-directed integration of the Corynebacterium phage Phi-16: construction of the integration vector ", Microbiol，145：539-548(1999)
	Y12537	proP	proline/ectoine uptake system protein	Peter, h, et al, "corynebacterium glutamicum is provided with four second vectors matching solutes: proline/ectoine uptake Identification, sequencing and characteristic identification of the system-entering Prop and ectoine/proline/betaine carrier EctP, J.Bacteriol.，180(22)：6005-6012(1998)

table 2 (continuation)
	Y13221	glnA	Glutamine synthetase I	Jakoby, M. et al, "isolation of the glnA gene from C.glutamicum coding for glutamine synthetase I", FEMS Microbiol.Lett.，154(1)：81-88(1997)
Y16642					lpd	dihydrothiooctanoic acid amide dehydrogenase
	Y18059		Attachment site Corynebacterium phage 304L	Moreau, S, et al "φ analysis of the 304L integration function: integrase group in corynebacterium bacteriophage Member ", Virology, 255 (1): 150-159(1999)
Z21501					argS；lysA	arginyl-tRNA synthetase; diaminopimelic acid Decarboxylase (partial)	Oguiza, J.A, et al, "Gene encoding arginyl-tRNA synthetase is located in lysA Gene of Brevibacterium lactofermentum In the upstream zone of (a): regulation of argS-lysA cluster expression "by arginine, j. bacteriol, 175(22)：7356-7362(1993)
	Z21502	dapA；dapB	a dihydro-2, 6-pyridinedicarboxylic acid synthase; dihydro 2, 6-pyridinedicarboxylic acid reductase	Pisabaro, A. et al "Gene clusters of three genes of Brevibacterium lactofermentum (dapA, orf2, and dapB) Dihydro-2, 6-pyridinedicarboxylic acid reductase and a third polypeptide "of unknown function, j.bacteriol, 175(9)：2743-2749(1993)
Z29563					thrC	threonine synthase	Malumbres, m. et al "analysis and expression of thrC gene encoding threonine synthase", Appl. Environ.Microbiol.，60(7)2209-2219(1994)
	Z46753	16S rDNA	16S ribosomal RNA gene
Z49822					sigA	SigA sigma factor	Oguiza, j.a. et al "multiple sigma factor genes in b.lactofermentum: characterization of sigA and sigB, J.Bacteriol.，178(2)：550-553(1996)
	Z49823	galE；dtxR	catalytically active UDP-galactose 4-epimerase; white colour (Bai) Laryngotoxin modulator proteins	Oguiza, J.A. et al, "Brevibacterium lactofermentum genes encoding UDP-galactose 4-epimerase and dmdR Gene transcription coupling ", Gene, 177: 103-107(1996)
Z49824					orfl；sigB	Is there a (ii) a SigB sigma factor	Oguiza, j.a. et al "multiple sigma factor genes in b.lactofermentum: characterization of sigA and sigB, J.Bacteriol.，178(2)：550-553(1996)
	Z66534		transposase	Correia, A. et al "g of IS-like elements present in the genome of Brevibacterium lactofermentum ATCC 13869 Clone and signature, Gene, 170 (1): 91-94(1996)
1 the sequence of this gene is published in the indicated reference. However, the sequences obtained by the inventors of the present application are significantly longer than the published forms. The published form is believed to be dependent on an incorrect start codon, and is therefore only generations Table fragments of the actual coding region.

Table 3: corynebacterium and Brevibacterium strains that can be used to practice the present invention

Bacterial strain	ATCC	PERM	NRRL	CECT	NCIMB	CBS	NCTC	DSMZ
									Brevibacterium ammoniagenes (Brevibacterium ammoniagenes)	21054
Brevibacterium ammoniagenes	19350
									Brevibacterium ammoniagenes	19351
Brevibacterium ammoniagenes	19352
									Brevibacterium ammoniagenes	19353
Brevibacterium ammoniagenes	19354
									Brevibacterium ammoniagenes	19355
Brevibacterium ammoniagenes	19356
									Brevibacterium ammoniagenes	21055
Brevibacterium ammoniagenes	21077
									Brevibacterium ammoniagenes	21553
Brevibacterium ammoniagenes	21580
									Brevibacterium ammoniagenes	39101
Brevibacterium butanicum	21196
									Corynebacterium glutamicum (Brevibacterium divaricatum)	21792	P928
Brevibacterium flavum (Brevibacterium flavum)	21474
									Brevibacterium flavum	21129
Brevibacterium flavum	21518
									Brevibacterium flavum			B11474
Brevibacterium flavum			B11472
									Brevibacterium flavum	21127
Brevibacterium flavum	21128
									Brevibacterium flavum	21427
Brevibacterium flavum	21475
									Brevibacterium flavum	21517
Brevibacterium flavum	21528
									Brevibacterium flavum	21529
Yellow shortBacillus			B11477
									Brevibacterium flavum			B11478
Brevibacterium flavum	21127
									Brevibacterium flavum			B11474
Brevibacterium shigella (Brevibacterium healii)	15527
									Brevibacterium ketoglutarate (Brevibacterium ketoglutamicum)	21004
Brevibacterium ketoglutarate	21089
									Brevibacterium ketoglutarate	21914
Hair for breastBrevibacterium saccharolyticum				70
									Brevibacterium lactofermentum				74
Brevibacterium lactofermentum				77
									Brevibacterium lactofermentum	21798
Brevibacterium lactofermentum	21799
									Brevibacterium lactofermentum	21800
Brevibacterium lactofermentum	21801
									Brevibacterium lactofermentum			B11470
Brevibacterium lactofermentum			B11471
									Brevibacterium lactofermentum	21086
Brevibacterium lactofermentum	21420
									Brevibacterium lactofermentum	21086

Brevibacterium lactofermentum	31269
									Brevibacterium expansum (Brevibacterium linens)	9174
Brevibacterium expansum	19391
									Brevibacterium expansum	8377
Brevibacterium paraffinolyticum					11160
									Brevibacterium sp (Brevibacterium spec.)						717.73
Brevibacterium sp						717.73
									Brevibacterium sp	14604
Brevibacterium sp	21860
									Brevibacterium sp	21864
Brevibacterium sp	21865
									Brevibacterium sp	21866
Brevibacterium sp	19240
									Corynebacterium acetoacidophilum (Corynebacterium acetoacidophilum)	21476
Corynebacterium acetoacidophilum	13870
									Corynebacterium acearum (Corynebacterium glutamicum) acetoglutamiphilum)			B11473
Corynebacterium glutamicum			B11475
									Corynebacterium glutamicum	15806
Corynebacterium glutamicum	21491
									Corynebacterium glutamicum	31270
Corynebacterium acetoacidophilum (Corynebacterium acetophilum)			B3671
									Corynebacterium ammoniagenes	6872						2399
Corynebacterium ammoniagenes	15511
									Corynebacterium fujiokense	21496
Corynebacterium glutamicum	14067
									Corynebacterium glutamicum	39137
Corynebacterium glutamicum	21254
									Corynebacterium glutamicum	21255
Corynebacterium glutamicum	31830
									Corynebacterium glutamicum	13032
Corynebacterium glutamicum	14305
									Corynebacterium glutamicum	15455
Corynebacterium glutamicum	13058
									Corynebacterium glutamicum	13059
Corynebacterium glutamicum	13060
									Corynebacterium glutamicum	21492
Corynebacterium glutamicum	21513
									Corynebacterium glutamicum	21526
Corynebacterium glutamicum	21543
									Corynebacterium glutamicum	13287
Corynebacterium glutamicum	21851
									Corynebacterium glutamicum	21253
Corynebacterium glutamicum	21514
									Corynebacterium glutamicum	21516
Corynebacterium glutamicum	21299
									Corynebacterium glutamicum	21300
Corynebacterium glutamicum	39684
									Corynebacterium glutamicum	21488
Corynebacterium glutamicum	21649

Corynebacterium glutamicum	21650
									Corynebacterium glutamicum	19223
Corynebacterium glutamicum	13869
									Corynebacterium glutamicum	2l157
Corynebacterium glutamicum	21158
									Corynebacterium glutamicum	21159
Corynebacterium glutamicum	21355
									Corynebacterium glutamicum	31808
Corynebacterium glutamicum	21674
									Corynebacterium glutamicum	21562
Corynebacterium glutamicum	21563
									Corynebacterium glutamicum	21564
Corynebacterium glutamicum	21565
									Corynebacterium glutamicum	21566
Corynebacterium glutamicum	21567
									Corynebacterium glutamicum	21568
Corynebacterium glutamicum	21569
									Corynebacterium glutamicum	21570
Corynebacterium glutamicum	21571
									Corynebacterium glutamicum	21572
Corynebacterium glutamicum	21573
									Corynebacterium glutamicum	21579
Corynebacterium glutamicum	19049
									Corynebacterium glutamicum	19050
Corynebacterium glutamicum	1905l
									Glutamic acidCorynebacterium species	19052
Corynebacterium glutamicum	19053
									Corynebacterium glutamicum	19054
Corynebacterium glutamicum	19055
									Corynebacterium glutamicum	19056
Corynebacterium glutamicum	19057
									Corynebacterium glutamicum	19058
Corynebacterium glutamicum	19059
									Corynebacterium glutamicum	19060
Corynebacterium glutamicum	19185
									Corynebacterium glutamicum	13286
Corynebacterium glutamicum	21515
									Corynebacterium glutamicum	21527
Corynebacterium glutamicum	21544
									Corynebacterium glutamicum	21492
Corynebacterium glutamicum			B8183
									Corynebacterium glutamicum			B8182
Corynebacterium glutamicum			B12416
									Corynebacterium glutamicum			B12417
Corynebacterium glutamicum			B12418
									Corynebacterium glutamicum			B11476
Corynebacterium glutamicum	21608
									Corynebacterium lilium (Corynebacterium lilium)		P973
Corynebacterium nitrilophilus	21419				11594
									Corynebacterium species (Corynebacterium spec.)		P4445
Corynebacterium species		P4446
									Corynebacterium species	31088

Corynebacterium species	31089
									Corynebacterium species	31090
Corynebacterium species	31090
									Corynebacterium species	31090
Corynebacterium species	15954							20145
									Corynebacterium species	21857
Corynebacterium species	21862
									Corynebacterium species	21863

ATCC: american type culture Collection, Rockville, Md., USA

FERM: institute for fermentation, Chiba, Japan

NRRL: culture Collection of the agricultural research institute, Northern Regional research laboratory, Peoria, IL, USA

CECT: spanish type culture Collection, Valencia, Spanish

NCIMB: national Industrial and Marine microbial Collection Ltd, Aberdeen, UK

And (3) CBS: fungal species Collection, Baarn, the Netherlands

NCTC: national center for type culture Collection, London, UK

DSMZ: deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH, Braunschweig, Germany

For reference see Sugawara, H. et al (1993) World direction of collections of microorganisms: bacteria, fungi and yeasts (4 th edition), World labor for culture collections World data center on microorganisms, Saimata, Japan.

Table 4: sequence alignment results ID # Length Genbank hit name Genbank hit homology% entry date

(NT) Source (GAP) rxa 000511527 GB _ HTG 3: AC 009685210031 AC009685 human chromosome 15 clone 91_ E _13map15,^***sequencing is in progress^***27 persons (Homo sapiens) 34,24799-09-29

Non-sequential fragments (pieces).

GB _ HTG 3: AC 009685210031 AC009685 human chromosome 15 clone 91_ E _13map15,^***sequencing is in progress^***27 human 34,24799-09-29

Non-sequential fragments.

GB _ HTG 7: AC 009511271896 AC009511 human clone RP11-860B13,^***sequencing is in progress^***59 non-sequential persons 35,0331999-12-09

And (4) section. rxa 00091876 GB _ BA 1: D50453146191D 50453 Bacillus subtilis DNA containing the 25-36 degree region of the amyE-srfA region, the entire coding region. Bacillus subtilis 54,45299-02-10

GB _ BA 1: SCI 5140745 AL109848 Streptomyces coelicolor cosmid I51. Streptomyces coelicolor 36,80699-08-16

(Streptomyces coelicolor)A3(2)

GB _ BA 1: ECOUW 93338534U 14003 E.coli K-12 chromosome region from 92.8 to 00.1 minutes. Escherichia coli 38,64296-04-17 rxa 00092789 GB _ BA 1: SCH 3545396 AL078610 Streptomyces coelicolor cosmid H35. Streptomyces coelicolor 49,93499-06-04

GB _ HTG 3: AC 011498-312343 AC011498 human chromosome 19 clone CIT978 SKB-50L 17,^***sequencing is in progress^***People, a 37,117 99-12-13

0190 non-sequential fragments.

GB _ HTG 3: AC 011498-312343 AC011498 human chromosome 19 clone CIT978 SKB-50L 17,^***sequencing is in progress^***Human 37,11799-12-13

0190 non-sequential fragments. rxa 00104879 GB _ BA 1: MTCY 27037586Z 95388 Mycobacterium tuberculosis H37Rv complete genome; and a section 96/162. Mycobacterium tuberculosis 36,73299-02-10

(Mycobacterium tuberculosis)

GB _ PL 2: T24M 868251 AF077409 Arabidopsis thaliana BAC T24 MB. Arabidopsis thaliana 37,15098-08-03

(Arabidopsis thaliana)

GB _ BA 1: MTCY 27037586Z 95388 Mycobacterium tuberculosis H37Rv complete genome; and a section 96/162. Mycobacterium tuberculosis 42,87499-02-10 rxa 001135745 GB _ BA 1: FASGEN 10520X 87822 Brevibacterium ammoniagenes FAS gene. Corynebacterium ammoniagenes 68,3811996-10-03

GB _ BA 1: BAFASAA 10549X 64795 Brevibacterium ammoniagenes FAS gene. Corynebacterium ammoniagenes 57,2591997-10-14

GB _ BA 1: MTCY 15933818Z 83863 M.tuberculosis H37Rv complete genome; and a section 111/162. Mycobacterium tuberculosis 39,87098-06-17 rxa 001641812 GB _ HTG 2: HSJ1153D 9118360 AL109806 human chromosome 20 clone RP5-1153D9,^***sequencing is in progress^***Is nobody 35,7141999-12-03

And (5) sequencing the fragments.

GB _ HTG 2: HSJ1153D 9118360 AL109806 human chromosome 20 clone RP5-1153D9,^***sequencing is in progress^***Is nobody 35,7141999-12-03

And (5) sequencing the fragments.

GB_HTG2：HSJ11Chromosome 20 clone RP5-1153D9 of 53D 9118360 AL109806,^***sequencing is in progress^***Is nobody 35,73341999-12-03

And (5) sequencing the fragments. rxa 001811695 GB _ BA 1: CGPUTP 3791Y 09163 Corynebacterium glutamicum putP gene. Corynebacterium glutamicum 100,00097-09-08

GB _ BA 2: U3281410393U 32814 Haemophilus influenzae Rd complete genome region 129/163(section 129 of 163). Haemophilus influenzae 36,3471998-05-29

(Haemophilus influenzae)Rd

GB _ BA 1: CGPUTP 3791Y 09163 Corynebacterium glutamicum putP gene. Corynebacterium glutamicum 37,45497-09-08 rxa 00186870 GB _ PR 3: AC 004843136655 AC 004843A human PAC clone DJ0612F12 from 7p12-p 14. Human 37,31598-11-05

Table 4 (continuation)

GB _ HTG 2: HS745I 14133309 AL033532 human chromosome 1 clone RP4-745I14map q23.1-24.3,^***sequencing of on-going human 38,1291999-12-03

In^***And are non-sequential fragments.

GB _ HTG 2: HS745I 14133309 AL033532 human chromosome 1 clone RP4-745I14map q23.1-24.3,^***sequencing of on-going human 38,1291999-12-03

In^***And are non-sequential fragments. rxa 00187474 GB _ GSS 10: AQ 184082506 AQ184082 HS _3216_ A1_ G08_ T7CIT approved human genome sperm library D human genome human 37,29798-11-01

Clone plate column 3216 line 15 line M, genome overview sequence.

GB _ GSS 1: CNS008ZZ 1101 AL 052951A Drosophila melanogaster 34,12099-06-03 of a Drosophila melanogaster from a RPCI-98 library BAC # BACR18L01 of Drosophila melanogaster (Drosophila melanogaster)

Fly genome review sequence end T7, genome review sequence. (Droeophila melanogaster)

GB _ GSS 10: AQ 184082506 AQ184082 HS _3216_ A1_ G08_ T7CIT approved human genome sperm library D human genome human 39,65598-11-01

Clone plate column 3216 line 15 line M, genome overview sequence. rxa 00201292 GB _ PR 3: HSJ824F 16139330 AL050325 is the human DNA sequence on chromosome 20 from clone 824F16, complete sequence. Human 34,52099-11-23

GB _ BA 1: RCSECA 2724X 89411 rhodobacter enveloped secA gene DNA. Rhodobacteria sandwiched 38,1639601-06

(Rhodobacter capsulatus)

GB _ EST 34: AV 122904242 AV122904 AV122904 Mucuna birdwoodiana C57BL/6J 10-day embryo Mucuna birdwoodiana cDNA clone Mucuna birdwoodiana 38,88999-07-01

2610529H07, mRNA sequence. (Mus musculus) rxa 00228714 GB _ EST 15: AA 486042515 AA486042 ab40c08.r1.Stratagene HeLa cells s 3937216 human cDNA clone human 37,5001998-03-06

IMAGE: 8432785', mRNA sequence.

GB _ EST 15: AA 486042515 AA486042 ab40c08.r1.Stratagene HeLa cells s 3937216 human cDNA clone human 38,8161998-03-06

IMAGE: 8432785', mRNA sequence. rxa 002431140 GB _ PR 2: CNS01DS 5101584 AL121655 BAC sequence of SPG4 candidate region from 2p21-2p22, complete human 37,00199-09-29

GB _ HTG 3: AC 01140879332 AC011408 human clone CIT978SKB _65D22,^***sequencing is in progress^***10 non-sequential persons 38,0401999-10-06

And (3) fragment.

GB _ HTG 3: AC 01140879332 AC011408 human clone CIT978SKB _65D22,^***sequencing is in progress^***10 non-sequential persons 38,0401999-10-06

And (3) fragment. rxa002592325 GB _ HTG 1: CEY62E 10254217 AL031580 Caenorhabditis elegans chromosome IV clone Y62E10,^***sequencing of the ongoing Caenorhabditis elegans 36,77699-09-06

In^***And are non-sequential fragments.

GB _ HTG 1: CEY62E 10254217 AL031580 Caenorhabditis elegans chromosome IV clone Y62E10,^***sequencing of on-going Caenorhabditis elegans 36,7769909-06

In^***And are non-sequential fragments.

GB _ PL 2: YSCCHROM 41988L 22015 Saccharomyces cerevisiae chromosome I centromere and right arm sequences. Saccharomyces cerevisiae 39,2601998-03-05

(Saccharomyces cerevisiae) rxa 00269912 GB _ HTG 4: AC 009974219565 AC009974 human chromosome unknown clone NH0459I19, WORKINGDRAFTSEQUENCE, human 37,3581999-10-29

Are non-sequential fragments.

GB _ HTG 4: AC 009974219565 AC009974 human chromosome unknown clone NH0459I19, WORKINGDRAFTSEQUENCE, human 37,3581999-10-29

Are non-sequential fragments.

GB _ BA 1: AB 01750832050 AB017508 Bacillus halodurans C-125 genomic DNA, 32kb fragment, complete coding region. Bacillus halodurans 44,62299-04-14 rxa 00281766 GB _ BA 1: SCE 824700 AL035654 Streptomyces coelicolor cosmid E8. Streptomyces coelicolor 36,3281999-03-11

GB _ BA 1: SCU 513323216U 51332 S.coelicolor histidine kinase homolog (absA1) and effector homolog S.coelicolor 39,08996-09-14

(absA2) gene, the entire coding region.

GB _ HTG 4: AC 011122187123 AC011122 human chromosome 8 clone 23_ D _19map 8,^***sequencing is in progress^***27 persons 38,6581999-10-14And (5) sequencing the fragments.

Table 4 (continuation) rxa 002981968 GB _ BA 1: CGECTP 2719 AJ001436 Corynebacterium glutamicum ectoP gene. Corynebacterium glutamicum 100,00098-11-20

GB _ BA 1: CGECTP 2719 AJ001436 Corynebacterium glutamicum ectoP gene. Corynebacterium glutamicum 100,00098-11-20

GB _ EST 24: AI 234006432 AI234006 EST230694 standardized rat Lung, Bento Soares mouse (Rattus sp) cDNA clone mouse (Rttus sp.) 46,55299-01-31

RLUCU 013' end, mRNA sequence. rxa 00346813 GB _ BA 1: SC2E 920850 AL021530 Streptomyces coelicolor cosmid 2E 9. Streptomyces coelicolor 43,26798-01-28

GB _ BA 1: SC9B 124800 AL049727 Streptomyces coelicolor cosmid 9B 1. Streptomyces coelicolor 44,61399-04-27

GB _ BA 1: ECU 70214123171U 70214 E.coli chromosome 4-6 minutes. Escherichia coli 39,49096-09-21 rxa 003681698 GB _ BA 2: AF 06515935209 AF065159 putative arylsulfatase (arsA) of bradyrhizobium japonicum, putative soluble lytic bradyrhizobium japonicum 40,4091999-10-27

Transglycosylase precursor (sltA), dihydro-2, 6-dipicolinate synthase (dapA), MscL (Bradyrhizobium iaponicum)

(mscL), SmpB (smpB), BcpB (bcpB), RnpO (mpO), RelA/SpoT, and

line (relA), PdxJ (pdxJ) and acyl carrier protein synthase AcpS (acpS) genes

A whole coding region; prokaryotic type I signal peptidase SipF (sipF) Gene, sipF-sipS allele

Gene, entire coding region; rnase iii (rnc) gene, the entire coding region; GTP binding

Protein era (era) gene, part of the coding region; and unknown genes.

GB _ BA 1: AEOCHTT 16861D 63139 Aerobacter aerogenes chitinase gene, complete and partial coding region. Aeromonas sp 10S-2438,57799-02-13

GB _ EST 4: D62996314D 62996 HUM347G01B Clontech human aortic polyA + mRNA (#6572) human cDNA clone 41,61395-08-29

The cloned GEN-347G 015' end and mRNAsequence. rxa 00369817 GB _ BA 1: YP102KB 119443 AL031866 yersinia pestis 102 kilobase unstable region: 1-119443. Yersinia pestis 35,39699-01-04

(Yersinia pestis)

GB _ GSS 8: AQ 012142501 AQ012142 rhodobacter sphaeroides chromosome II genome clone 8750H1A037010398 rhodobacter sphaeroides 54,80098-06-04

8750H1A037010398 cosmid library, genome overview sequence. (Rhodobacter sphaeroides)

GB _ HTG 2: AC 005081180096 AC005081 human clone RG270D13,^***sequencing is in progress^***18 non-sequential fragments. Human 45,78698-06-12 rxa 00410789 GB _ BA 1: ATPLOCC 8870Z 30328 Agrobacterium tumefaciens Ti plasmids OccR, OccQ, OccM, Occp, OccT, OxB, Agrobacterium tumefaciens 46,4901994-10

The ptoxa and ornithine cyclodeaminase pTiAch5 genes. (Agrobacterium tumefaciens)

GB _ BA 2: U675919829U 67591 region 133/150 of the entire genome of Methanococcus jannaschii (section 133 of 150). Methanococcus jannaschii 45,67798-01-28

(Methanococcus jannaschii)

GB _ BA 1: TIPOCCQMP 4350M 80607 plasmid pTiA6 (from Agrobacterium tumefaciens) periplasmic octopine permease (occR, occQ, plasmid pTiA646, 49096-04-24

J occM, occP and ocj) and lysR-type regulatory protein (occR) genes, the entire coding region. rxa 00419882 GB _ BA 2: MSU 4684416951U 46844 Mycobacterium smegmatis catalase-peroxidase (katG), putative arabinosyl Mycobacterium smegmatis 57,0291997-05-12

The complete coding region of the transferase (embC, embA, embB) gene and theputative propionyl-CoA carboxy (Mycobacterium smegmatis)

The gene of the chemozyme β chain (pccB), part of the coding region.

GB _ EST 28: cloning of Drosophila melanogaster 37,6961999-03-16 from cDNA of Drosophila melanogaster AI 513245471 AI513245 GH13311.3prime.GH Drosophila melanogaster head pOT2

GH 133113 prime, mRNA sequence.

GB _ HTG 4: AC 010066187240 AC010066 drosophila melanogaster chromosome 3L/72A4 clone RPCI98-25O1,^***sequencing of ongoing Drosophila melanogaster 39,6071999-10-16

In^***70 non-sequential fragments. rxa 004321608 GB _ BA 1: BSUB 0015218410Z 99118 bacillus subtilis complete genome (region 15/21): 2795131-3013540. Bacillus subtilis 49,81097-11-26

GB _ PL 1: CAC35a 542565 AL033396 candida albicans cosmid Ca35 A5. Candida albicans 35,04198-11-05

(Candida albicans)

GB _ EST 13: AA 336266378 AA336266 EST40981 endometrium tumor human cDNA 5' end, mRNA sequence. Human 39,73397-04-21

Table 4 (continuation) rxa 004491704 GB _ HTG 2: AC 008199124050 AC008199 Drosophila melanogaster No. 3 chromosome clone BACR01K08(D756) RPCI-9801. K.8map Drosophila melanogaster 38,39299-08-02

94D-94D strain y；cn bw sp，^***Sequencing is in progress^***83 non-sequential

And (3) fragment.

GB _ HTG 2: AC 008199124050 AC008199 Drosophila melanogaster No. 3 chromosome clone BACR01K08(D756) RPCI-9801. K.8map Drosophila melanogaster 38,39299-08-02

94D-94D strain y；cn bw sp，^***Sequencing is in progress^***83 non-sequential

And (3) fragment.

GB _ RO: rathnkp 2177M 22337 rat connexin gene, exon 2. Mouse (Rattus sp.) 40,67893-04-27 rxa 004561500 GB _ GSS 1: FR 0030597476 AL026966 Fugu rubripesgs sequence, clone 091C22aF9, genomic review sequence. Fugu rubripes 47,40798-06-25

GB _ GSS 5: AQ 786587556 AQ786587 HS _3086_ B1_ H05_ MRCIT approved human genome sperm library D human gene human 38,40699-08-03

Panel clone plate 3086 column 9 row P, genome review sequences.

GB _ GSS 14: AQ 526586434 AQ526586 HS _5198_ B1_ B03_ SP6ERPCI-11 human Male BAC library human genome clone human 36,9511999-05-11

Panel 774 column 5 row D, genome overview sequence. rxa 004771767 GB _ EST 17: AA 610489407 AA610489 is similar to gb: m11353 HISTONE H3.3 (human) np93e05.sl human 41,7911997-12-09

NCI _ CGAP _ thy human cDNA clone IMAGE: 1133888, respectively; the mRNA sequence.

GB _ PR 1: HSH33G 41015X 05857 human HB3 gene exon 4. Human 38,18296-01-24

GB _ EST 30: AI 637667579 AI637667 tt10g11.x1 NCI _ CGAP _ GC6 human cDNA clone IMAGE: 22404203', human 35,41799-04-27

The mRNA sequence. rxa 00478954 GB _ HTG 3: AC 00870883932 AC008708 human chromosome 5 clone CIT978SKB _78F1,^***sequencing is in progress^***12 human 38,76999-08-03

Non-sequential fragments.

GB _ HTG 3: AC 00870883932 AC008708 human chromosome 5 clone CIT978SKB _78F1,^***sequencing is in progress^***12 human 38,76999-08-03

Non-sequential fragments.

GB _ HTG 3: AC 00870883932 AC008708 human chromosome 5 clone CIT978SKB _78F1,^***sequencing is in progress^***12 human 36,79799-08-03

Non-sequential fragments. rxa004801239 GB _ HTG 1: HSJ575L 2194715 AL096841 human chromosome 1 clone RP4-575L21,^***sequencing is in progress^***Is a non-compliant person 38,13899-11-23

And (4) sequencing fragments.

GB _ HTG 1: HSJ575L 2194715 AL096841 human chromosome 1 clone RP4-575L21,^***sequencing is in progress^***Is a non-compliant person 38,13899-11-23

And (4) sequencing fragments.

GB _ RO: AC 005960158414 AC005960 mouse chromosome 17BAC cith20h22 from the MHC region, complete sequence. Little mouse 38,7121998-12-01 rxa 00524433 GB _ BA 1: SC 15140745 AL109848 Streptomyces coelicolor cosmid I51. Streptomyces coelicolor A3(2) 40,28499-08-16

GB _ BA 2: AF 0828793434 AF082879 Yersinia enterocolitica ABC transporter enterochelatin/enterobactin gene cluster, complete sequence Yersinia enterocolitica 55,6341999-10-20

And (4) columns. (Yersinia enterocolitica)

GB _ BA 1: BSP 1326175192 AJ132617 Burkholderia P transporter operon and flanking genes. Burkholderia 40,79399-07-13

(Burkholderia sp.) rxa 00526813 GB _ BA 1: BSUB 0008208230Z 99111 bacillus subtilis complete genome (region 8/21): 1394791-1603020. Bacillus subtilis 54.53497-11-26

GB _ BA 2: AF 01228546864 AF012285 Bacillus subtilis mobA-nprE gene region. Bacillus subtilis 54,53498-07-01

GB _ BA 1: D9072513796D 90725 E.coli genomic DNA (19.7-20.0 min.). Escherichia coli 51,48199-02-07 rxa 005591140 GB _ BA 2: corynebacterium ammoniagenes 39,00798-01 upstream of CAU 779103385U 77910 Corynebacterium ammoniagenes 5-phosphoribosyl-1-pyrophosphorylase (purF) gene

And (4) columns.

GB _ EST 4: H34952382H 34952 is similar to NADH-coenzyme Q oxidoreductase complex I23kDa precursor (iron-sulfur protein) rat (Rattus sp.) 39,26798-04-02

EST108261 rat PC-12 cells, untreated rat (Rattus sp.) cDNA g of

Long RPCCK07, mRNA sequence. GB _ BA 2: AE 00096322014 AE000963 region 144/172 of the entire genome of archaeococcus scintillans. Archaeoglobus fulgidus 38,3381997-12-15

(Archaeoglobus fulgidus)

Table 4 (continuation) rxa 00570852 GB _ GSS 12: AQ 4224573 AQ422451 RPCI-11-185C3.TVRPCI-11 human genome clone RPCI-11-185C3, genome human 38,7671999-03-23

Sequences are reviewed.

GB _ EST 28: AI 504741568 AI504741 resembled the gb: mice of Z14044 37,9001999-03-11

vl16c01.x1 Stratagene mouse T cell 937311 mouse cDNA clone

IMAGE: 9723843'; the mRNA sequence.

GB _ EST 18: AA 71204368 AA712043 is similar to gb: vu29f10.r1 mice 42,6471997-12-24 of L0509360S ribosomal protein L18A (human)

Barstead mouse myotube MPLRB5 mouse cDNA clone IMAGE: 1182091

5'; the mRNA sequence. rxa 005711280 GB _ BA 1: MTCY 7833818Z 77165 M.tuberculosis H37Rv complete genome; and a section 145/162. Mycobacterium tuberculosis 38,46898-06-17

GB _ PR 3: AC 00578836224 AC005788 human chromosome 19, cosmid R26652, complete sequence. Human 36,9111998-10-06

GB _ PR 3: AC 00533834541 AC005338 human chromosome 19, cosmid R31646, complete sequence. Human 36,91198-07-30 rxa 005901288 GB _ HTG 6: AC 010932203273 AC010932 human chromosome 15 clone RP11-296E22map 15，^***Sequencing is underway 37,24299-11-30

^***36 non-sequential fragments.

GB _ HTG 6: AC 010932203273 AC010932 human chromosome 15 clone RP11-296E22 map15,^***sequencing is underway 36,48599-11-30

^***36 non-sequential fragments.

GB _ BA 1: MSGB26CS 37040L 78816 M.leprae cosmid B26DNA sequence. Mycobacterium leprae 39,27296-06-15

(Mycobacterium leprae) rxa 005911476 GB _ IN 1: CEK09E 930098Z 79602 Caenorhabditis elegans cosmid K09E9, complete sequence. Caenorhabditis elegans 34,09299-09-02

GB _ PR 4: AF 1358024965 AF135802 human thyroid hormone receptor associated protein complex component TRAP170mRNA, wholly coded human 36,31099-04-09

And (5) code area.

GB _ PR 4: AN 1042564365 AF104256 human transcription coactivator CRSP150(CRSP150) mRNA, the entire coding region. Human 36,61799-02-04 rxa 00596576 GB _ PR 3: AC 004659129577 AC004659 human chromosome 19, CIT-HSP-87m17BAC clone, intact human 34,3211998-05-02

GB _ PR 3: AC 004659129577 AC004659 human chromosome 19, CIT-HSP-87m17BAC clone, intact human 35,7391998-05-02

GB _ PR 1: HUMCBP 22047D 83174 collagen binds to the human mRNA of protein 2, the entire coding region. Human 40,40499-02-06 rxa 00607504 GB _ BA 1: MTV 0103400 AL021186 M.tuberculosis H37Rv complete genome; and a section 119/162. Mycobacterium tuberculosis 40,86299-06-23

GB _ BA 1: MTV 0103400 AL021186 M.tuberculosis H37Rv complete genome; and a section 119/162. Mycobacterium tuberculosis 38,83399-06-23 rxa 006231461 GB _ BA 1: MTCY 42826914Z 81451 Mycobacterium tuberculosis H37Rv complete genome; and a section 107/162. Mycobacterium tuberculosis 60,55298-06-17

GB _ BA 1: RSPNGR 23434010Z 68203 Rhizobium plasmid NGR234a DNA. Rhizobium sp 51,99296-08

GB _ BA 2: AE 00010110057 AE000101 rhizobium NGR234 plasmid pNGR234a, region 38/46 of the complete plasmid sequence. Rhizobiam (Rhizobium sp.) NGR 23451,9921997-12-12 rxa00681rxa 006901269 GB _ HTG 5: AC 008338136685 AC008338 Drosophila melanogaster chromosome X clone BACR30J04(D908) RPCI-9830. J.4map Drosophila melanogaster 35,34199-11-15

19C-19E strain y-；cn bw sp，^***Sequencing is in progress^***93 non-sequential

And (3) fragment.

GB _ HTG 4: AC 009766170502 AC009766 human chromosome 11 clone 404_ A _03 map 11,^***sequencing is in progress^***Human 37,9841999-10-19

27 non-sequential fragments.

Table 4 (continuation)

GB _ HTG 4: AC 009766170502 AC009766 No. 11 dyeThe chromosome clone 404-03 map 11,^***sequencing is in progress^***27 human 37,9841999-10-19

Non-sequential fragments. rxa 007331008 GB _ EST 30: AU 054038245 AU054038 AU054038 Dictyyostelium discoidea SL (H.Urushihara) Dictyyostelium discoidea 43,26599-04-28

discoidea cDNA clone SLK472, mRNA sequence.

GB_EST30：AU054038 245 AU054038 AU054038 Dictyostelium discoideum SL(H.Urushihara)Dictyostelium Dictyostelium discoideum 43,265 99-04-28

discoidea cDNA clone SLK472, mRNA sequence. rxa 00735692 GB _ BA 1: MTCY 5036030Z 77137 complete genome of Mycobacterium tuberculosis H37 Rv; and a section 55/162. Mycobacterium tuberculosis 36,81998-06-17

GB _ BA 1: D90904150894D 90904 Synechocystis, sp.PCC6803 complete genome, 6/27, 630555-781448. Synechocystis, sp 52,58599-02-07

GB _ BA 1: D90904150894D 90904 Synechocystis, sp.PCC6803 complete genome, 6/27, 630555-781448. Synechocystis, sp. 39,69999-02-07 rxa 00796298 GB _ GSS 14: AQ 579838651 AQ579838 BAC clone 31P06Medicago truncatula genomic clone 31-P-06-C-054 Medicago truncatula 37,15399-09-27

T135342b shotgun sublibrary, genome overview sequence.

GB _ PR 4: AC 007625174701 AC007625 comes from the genomic sequence, complete sequence, of human clone 2314F2 of chromosome 18. Human 38,01499-06-30

GB _ EST 14: AA 427576580 AA427576 is similar to gb: m86852 peroxide object Assembly factor-1 (human) zw54b04.s1 human 42,7311997-10-16

Somers _ total _ failure _ Nb2HF8_9w human cDNA clone IMAGE: 7738393',

the mRNA sequence. rxa 00801756 GB _ BA 1: MTV 02213025 AL021925 M.tuberculosis H37Rv complete genome; and a section 100/162. Mycobacterium tuberculosis 59,35098-06-17

GB _ RO: AC 002109160048 AC002109 is derived from the genomic sequence, complete sequence, of mouse 9. Little mouse 39,39897-09

GB _ BA 1: MTV 02213025 AL021925 M.tuberculosis H37Rv complete genome; and a section 100/162. Mycobacterium tuberculosis 36,84298-06-17 rxa 00802837 GB _ GSS 14: AQ 56349642 AQ 5656349 HS _5335_ B2_ A09_ T7ARPCI-11 human Male BAC library human genome clone human 37,6491999-05-29

Plate 911 column 18 row B, genome overview sequence.

GB _ BA 1: DIHCLPBA 2441M 32229 encodes the metione clpB gene of the ATP-dependent protease regulatory subunit. Arthroma Artiomorpha 41,14093-04-26

(Dichelobacter nodosus)

GB _ GSS 3: B61538698B 61538T 17M17TR TAMU arabidopsis thaliana genomic clone T17M17, genome review sequence. Arabidopsis 36,94697-11-21 rxa 008191452 GB _ HTG 3: AC008691 u110000 AC008691 human chromosome 5 clone CIT978SKB _63A22,^***sequencing is in progress^***Human 38,27099-08-03

1253 non-sequential fragments.

GB _ HTG 3: AC008691_ 110000 AC008691 human chromosome 5 clone CIT978SKB _63A22,^***sequencing is in progress^***Human 38,27099-08-03

1253 non-sequential fragments.

GB _ HTG 3: AC 009127186591 AC009127 human chromosome 16 clone RPCI-11_498D10,^***sequencing is in progress^***49 human 38,94799-08-03

Non-sequential fragments. rxa 00821966 GB _ HTG 1: HS32B 1271488 AL023693 human chromosome 6 clone RP1-32B1,^***sequencing is in progress^***Is non-sequential human 36,56599-11-23

And (3) fragment.

GB _ HTG 1: HS32B 1271488 AL023693 human chromosome 6 clone RP1-32B1,^***sequencing is in progress^***Is non-sequential human 36,56599-11-23

And (3) fragment.

GB _ PR 3: AC 00491975547 AC004919 was from the UL human PAC clone DJ0895B23, complete sequence. Human 34,34698-09-19 rxa 00827876 GB _ EST 6: W06539300W 06539T 2367 MVAT4 blood stream form SerodemeWRATtl.1 Rod west Brookfield Trypanosoma brucei Rodebi 40,00096-08-12

Insect cDNA 5', mRNA sequence. (Trlypanosoma brucei rhodesiense)

GB _ PR 4: AC 008179181745 AC008179 human clone NH0576P01, complete sequence. Human 35,90399-09-28

Table 4 (continuation)

GB _ EST 18: irradiation of Colon MPLRB7 mice AA 710415533 AA710415 vt53f08.r1 Barstead mice murine cDNA clone mice 41,5621997-12-24

IMAGE: 11668235', mRNA sequence. rxa 008421323 GB _ PR 2: AC 002379118595 AC002379 from 7q21 human BAC clone GS165I04, complete sequence. Human 36.32197-07-23

GB _ PR 2: AC 002379118595 AC002379 from 7q21 human BAC clone GS165I04, complete sequence. Human 37,28497-07-23

GB _ IN 1: CEF02D 831624Z 78411 Caenorhabditis elegans cosmid F02D8, complete sequence. Caenorhabditis elegans 38,16398-11-23 rxa 008471572 GB _ OV: XeRDS 38A 1209L 79915 has Xenopus rds/peripherin (rds38) mRNA, the entire coding region. Rhizoma et radix Xenopodii (Bufo siccus) 36,04497-07-30

(Xenopus laevis)

GB _ HTG 4: AC 007920234529 AC007920 human chromosome 3q27 clone RPCI11-208N14,^***sequencing is in progress^***51 people 33,7421999-10-21

Non-sequential fragments.

GB _ HTG 4: AC 007920234529 AC007920 human chromosome 3q27 clone RPCI11-208N14,^***sequencing is in progress^***51 human 33,7421999-10-21

Non-sequential fragments. rxa 00851732 GB _ HTG 2: AC 004064185000 AC004064 human chromosome 4,^***sequencing is in progress^***10non-sequential fragments. Human 39,83398-07-09

GB _ HTG 2: AC 004064185000 AC004064 human chromosome 4,^***sequencing is in progress^***10 non-sequential fragments. Human 39,83398-07-09

GB _ PR 3: HSJ824F 16139330 AL050325 is derived from the human DNA sequence of clone 824F16 on chromosome 20, complete sequence. Human 39,83399-11-23 rxa 00852813 GB _ HTG 3: AC 010120121582 AC010120 Drosophila melanogaster No. 3 chromosome clone BACR22N13(D1061) RPCI-9822. N.13 Drosophila melanogaster 36,85599-09-24

map 96F-96F strain y；cn bw sp，^***Sequencing is in progress^***83 non-compliant

And (4) sequencing fragments.

GB _ HTG 3: AC 010120121582 AC010120 Drosophila melanogaster No. 3 chromosome clone BACR22N13(D1061) RPCI-9822. N.13 Drosophila melanogaster 36,85599-09-24

map96F-96F strain y；cn bw sp，^***Sequencing is in progress^***83 non-compliant

And (4) sequencing fragments.

GB _ HTG 2: AC 006898299308 AC006898 Caenorhabditis elegans clone Y73B6x,^***sequencing is in progress^***，9 Caenorhabditis elegans 36,768 99-02-24

Non-sequential fragments. rxa00856rxa 008701635 GB _ BA 1: STMMSDA 3986L 48550 A.coelicolor semialdehyde malonate dehydrogenase (msdA) gene, the entire coding region. Streptomyces coelicolor 63,7431996-05-09

GB _ PAT: I92043713I 92043 is from sequence 10 of patent US 5726299. Not known 38,8501998-12-01

GB _ PAT: I78754713I 78754 is from sequence 10 of patent US 5693781. Unknown 38,85098-04-03 rxa 00875690 GB_ BA 2: AF 119715549 AF119715 E.coli isopentyl diphosphate isomerase (idi) gene, the entire coding region. Escherichia coli 54,82799-04-22

GB _ BA 2: AE 00037212144 AE000372 region 262/400 of the complete genome of E.coli K-12MG 1655. Escherichia coli 51,41698-11-12

GB _ BA 1: ECU 2837555175U 28375 Escherichia coli K-12 genome; about 64-65 minutes. Escherichia coli 51,4161995-12-08 rxa 008781986 GB _ HTG 2: AC 007472113 AC007472 Drosophila melanogaster No. 2 chromosome clone BACR30D19(D587) RPCI-9830. D.19map Drosophila melanogaster 36,59299-08-02

49E-49F strain y；cn bw sp，^***Sequencing is in progress^***79 non-sequential sheets

And (4) section.

GB _ HTG 2: AC 007472113 AC007472 Drosophila melanogaster No. 2 chromosome clone BACR30D19(D587) RPCI-9830. D.19map Drosophila melanogaster 36,59299-08-02

49E-49F strain y；cn bw sp，^***Sequencing is in progress^***79 non-sequential sheets

And (4) section.

GB _ HTG 2: AC 006798207370 AC006798 Caenorhabditis elegans clone Y51F8,^***sequencing is in progress^***30 Caenorhabditis elegans 36,69999-02-25

Non-sequential fragments.

Table 4 (continuation) rxa 008801968 GB _ EST 4: H22888468H 22888 ym54e12. r1Soares infant brain 1NIB human cDNA clone IMAGE: 521585', human 37,17995-07-06

The mRNA sequence.

GB _ GSS 13: AQ 426858516 AQ426858 CITBI-E1-2578F1.TFCITBI-E1 human genome clone 2578F1, genome synthesis 38,4471999-03-24

The sequence

GB _ PR 1: AB 0023356289 human mRNA of AB002335 KIAA0337 gene, the entire coding region. Human 35,79999-02-13 rxa 008991389 GB _ BA 1: NGU 588492401U 58849 Neisseria gonorrhoeae pilS6 silences the hair (pilus) locus. Neisseria gonorrhoeae 40,62396-06-20

(Neisseria gonorrhoeae)

GB _ BA 1: plasmid pSa (from E.coli) dihydropteroate synthase gene 3' of PLPDHOS 3119L 06822. Plasmid pSa 38,9661996-03-20

GB _ BA 1: PDGINTORF 6747L 06418 integrant In7 (plasmid pDGO100 from Escherichia coli) integrase (int), aminosugar plasmid pDGO 10038, 9661996-03-20

Glycoside adenylyltransferase (aad), Quaternary ammonium Compound resistance protein, dihydrofolate reductase

(dhfrX) and dihydropteroate synthase (sull) genes. rxa 009021333 GB _ GSS 15: AQ 606873581 AQ606873 HS-5404-B2-H05-T7 ARPCI-11 human male BAC library human genome clone 37,90099-06-10

Clone-plate 980 line 10 line P, genome review sequences.

GB _ GSS 9: AQ 163442658 AQ163442 nbxb0007A07fCUGI Rice BAC library Rice genome clone nbxb0007A07f, Rice (Oryza sativa) 41,88598-09-12

Genome review sequences.

GB _ PL 1: the pea PSST70 gene of PSST 704974X 69213 heat shock protein. Pea (Pisum sativum) 36,86696-07-03 rxa 00931969 GB _ GSS 1: FR 0025208612 AL018047 f. rubipses sequence, clone 145D10aA8, genome review sequence. Fugu rubripes 37,8151997-12-10

GB _ GSS 1: FR 0021844252 AL014715 f. rubipes GSS sequence, clone 069K22aG5, genome review sequence. Fugu rubripes 37,6981997-12-10

GB _ BA 2: MSGKATG 1745L 14268 HS _2257_ B1_ B03_ T7CCrT approved human genome sperm library D human-based human 31,5521999-03-13

Genome review sequences were obtained from genebank clone plates ═ 2257 columns ═ 5 rows ═ D. rxa 009411440 GB _ BA 1: MTCY 18044201Z 97193 complete genome of Mycobacterium tuberculosis HB7 Rv; and a section 85/162. Mycobacterium tuberculosis 37,90298-06-17

GB _ BA 1: MTCY 18044201Z 97193 complete genome of Mycobacterium tuberculosis H37 Rv; and a section 85/162. Mycobacterium tuberculosis 39,14098-06-17

GB _ GSS 12: AQ 403344593 AQ403344 Mycobacterium tuberculosis ethyl methanesulfonate resistance protein (katG) gene, 3' end. Mycobacterium tuberculosis 42,51799-08-26 rxa 00962689 GB _ HTG 6: AC 010998144338 AC010998 human clone RP11-95116,^***sequencing is in progress^***17 non-sequential persons 39,4971999-12-08

And (4) section.

GB _ GSS 1: GGA 340111990 AJ232089 derived from the sequence of the unknown sequence of the original chicken (cosmid 34-overlapping original chicken (Gallus balloon) 37,97098-08-25) mapping the cosmid on chromosome 2

Group 15), genome review sequences.

GB_HTG6：AC010998 144338 AC010998 human clone RP11-95I16,^***sequencing is in progress^***17 non-sequential persons 38,2261999-12-08

And (4) section. rxa 010601047 GB _ BA 1: ectoin 72280 AJ001816 Escherichia coli transposon Tn7 includes the left end of type 2 integrant, Escherichia coli 38,82297-11-04

GB _ IN 2: AF 1763778220 AF176377 Caenorhabditis briggsaeES-1 (ces-1) gene, complete coding region; and Caenorhabditis briggsae 39,9211999-12-09

CPN-1(CPN-1) gene, part of the coding region.

GB _ GSS 10: AQ 196728429 AQ196728 CIT-HSP-2381F4.TRCITHSP human genome clone 2381F4, genome overview human 39,01998-09-16

And (4) sequencing. rxa 01067852 GB _ BA 1: U0001642931U 00016 M.leprae cosmid B1937. Mycobacterium leprae 58,3031994-03-01

GB _ BA 1: SYCGROESL 3256D 12677 Synechocystis sp. Synechocystis sp. 34,59399-02-03

GB _ BA 1: D90905139467D 90905 Synechocystis sp.PCC6803 complete genome, 7/27, 781449-920915. Synechocystis sp. 34,59399-02-07 rxa 011141347 GB _ BA 1: PSEFAOAB 3480D 10390 Pseudomonas fragi faoA and faoB genes, the entire coding region. Pseudomonas fragi 51,91999-02

(Pseudomonas fragi)

Table 4 (continuation)

GB _ BA1 PhbB of AB 0147576057 AB014757 Pseudomonas 61-3, acetoacetyl-CoA reductase, β -ketothiolase and PHB Pseudomonas sp 61-350,5731998-12-26

The gene for the synthase, the entire coding region.

GB _ BA 1: SC8D 938681 AL035569 Streptomyces coelicolor cosmid 8D 9. Streptomyces coelicolor 42,20099-02-26 rxa 01136555 GB _ EST 11: AA 244557379 AA244557 mx07a01.r1 sores mouse NML mouse cDNA clone IMAGE: 6794645', little mouse 39,0501997-03-10

The mRNA sequence.

GB _ EST 14: AA 407673306 AA407673 EST01834 mouse 7.5dpc extraembryonic placental cone (cone) cDNA library mouse 38,56298-08-26

cDNA clone C0014F 023', mRNA sequence.

GB _ EST 26: AI 390328604 AI390328 mx07a01. r1Soares mouse NML mouse cDNA clone IMAGE: 6794645', little mouse 33,13699-02

The mRNA sequence. rxa 01138540 GB _ OV: XLXINT 11278X 13138 has int-1 Mrna of Xenopus int-1 protein. Xenopus laevis 40,0381995-03-31

GB _ PR 4: AC 006054143738 AC006054 human Xq28BACRPCI11-382P7 (Rosswellpark cancer institute human BAC human 37,99699-04-01

Library) the complete sequence.

GB _ PR 4: AC 006054143738 AC006054 human Xq28BAC RPCI11-382P7(Roswell Park Cancer Institute human BAC human 36,05399-04-01

Library) the complete sequence. rxa 011721578 GB _ BA 1: SCE 3923550 AL049573 streptomyces coelicolor cosmid E39. Streptomyces coelicolor 62,3571999-03-31

GB _ BA 1: MSU 503355193U 50335 mycobacterium smegmatis phage resistance (mpr) gene, the entire coding region. Mycobacterium smegmatis 37,85397-02-01

GB _ BA 1: BACTHRTR 15467D 84213 Bacillus subtilis genome, trnl-feuABC region. Bacillus subtilis 53,80799-02-06

NArxa 011911713 GB _ PR 2: HS1191B 260828 AL022237 was derived from the human DNA sequence of clone 1191B2 on chromosome 22q 13.2-13.3. Contains human 38,36699-11-23

BIK (NBK, BP4, BIP1) of BCL2 interaction killer (inducing apoptosis)

Part of the Gene-40S ribosomal protein S25 pseudogene and analogous to C

C50D2.7, a part of a novel acyltransferase gene. Contains EST, STS,

GSS, two putative CpG islands and the genomic marker D22S1151, complete sequence.

GB _ PR 2: HS1191B 260828 AL022237 was derived from the human DNA sequence of clone 1191B2 on chromosome 22q 13.2-13.3. Contains human 39,59599-11-23

BIK (NBK, BP4, BIP1) of BCL2 interaction killer (inducing apoptosis)

Part of the Gene-40S ribosomal protein S25 pseudogene and analogous to C

C50D2.7, a part of a novel acyltransferase gene. Contains EST, STS,

GSS, two putative CpG islands and the genomic marker D22S1151, complete sequence. rxa 01205554 GB _ BA 1: MTCY 37335516Z 73419 of the complete genome of mycobacterium tuberculosis H37 Rv; and a section 57/162. Mycobacterium tuberculosis 57,76298-06-17

GB _ PL 1: ATY 1277638483Y 12776 Arabidopsis DNA, 40kb around the ACS1 locus. Arabidopsis thaliana 32,97198-09-07

GB _ PL 2: ATT6K 2199643 AL021889 Arabidopsis DNA chromosome 4, BAC clone T6K21(ESSA project). Arabidopsis 35,27399-08-16 rxa 012121047 GB _ BA 2: SCD 2541622 AL118514 streptomyces coelicolor cosmid 25. Streptomyces coelicolor A3(2) 39,65499-09-21

GB _ BA1 SLGLYUB 2576X 65556 Streptomyces lividans tRNA-GlyU β Gene Streptomyces lividans 54,4931993-12-20

(Streptomyces lividans)

GB _ BA 1: SCH 1039524 AL049754 Streptomyces coelicolor cosmid H10. Streptomyces coelicolor 44,6381999-05-04 rxa 012191005 GB _ PAT: A68024520A 68024 was obtained from sequence 19 of patent WO 9743409. Unidentified 42,5531999-05

GB _ PAT: A68025193A 68025 from sequence 20 of patent WO 9743409. Unidentified 43,2291999-05

GB _ PAT: A68027193A 68027 is obtained from sequence 22 of patent WO 9743409. Unidentified 38,3421999-05

Table 4 (continuation) rxa 012201200 GB _ PR 3: HS512B 1164356 AL031058 is derived from the human DNA sequence of clone 512B11 on chromosome 6q 24-25. Contains desmosome 35,47899-11-23

The plagiosin I (DPI) gene, EST, STS and GSS, complete sequence.

GB _ EST 6: N99239424N 99239 zb76h11.s 1Soares _ senescent _ fibroblastits _ NbHSF human cDNA clone human 39,62396-08-20

IMAGE: 3095733', mRNA sequence.

GB _ EST 16: AA 554268400 AA554268 nk36c09.s1 NCI-CGAP _ GC2 human cDNA clone IMAGE: 10156003' and homo sapiens 36,11197-09-08

gb: x01677 liver (human) glyceraldehyde-3-phosphate dehydrogenase is similar; the mRNA sequence. rxa 01221849 GB _ PR 4: AF 17963396371 AF179633 human chromosome 16 map 16q23.3-24.1 sequence. Human 40,19999-09-05

GB _ VI: equine herpesvirus type EHVU 20824184427U 208242, complete genome. Equine herpes virus type 237,00196-02

GB _ BA 2: AE 00040710601 AE000407 E.coli K-12MG1655 region 297/400 of the complete genome. Escherichia coli 39,47198-11-12 rxa 01222822 GB _ PAT: AR 06862528804 AR068625 was obtained from sequence 1 of patent US 5854034. Unknown 40,57499-09-29

GB _ BA 2: SSU 5119728804U 51197 Sphingan polysaccharide Synthesis (spsG), (spsS), (spsR), Sphingomonas glycosylating (Sphingomonas sp.) 40,5741996-05-16

Transferases (spsQ), (spsL), glycosyltransferases (spsK), glycosyltransferases (spsL), (spsJ), S88

(spsF), (spsD), (spsC), (spsE), Urf32, Urf26, ATP-binding cassette transporter

Leukocyte (atrD), ATP-binding cassette transporter (atrB), glycosyl-prenyl phosphotransferase

(spsB), thymidine-1-phosphate (thymidylyl) transferase (rhsA), dTDP-6-

deoxy-D-glucose-3, 5-epimerase (rhsC), dTDP-D-glucose-4, 6-dehydratase

(rhsB), dTDP-6-deoxy-L-mannose-dehydrogenase (rhsD), Urf31 and Urf34 genes,

the entire coding region.

GB _ IN 1: BBU 449182791U 44918 babesia bovis ATP-binding protein (babc) mRNA, the entire coding region. Babesia bovis (Babesia bovis) 39,22897-08-09 rxa 012601305 GB _ BA 1: CGLPD 1800Y 16642 Corynebacterium glutamicum lpd gene, the entire coding region. Corynebacterium glutamicum 99,92399-02-01

GB _ BA 1: MTV 03816094 AL021933 Mycobacterium tuberculosis H37Rv complete genome; and a section 24/162. Mycobacterium tuberculosis 59,05698-06-17

GB _ PR 3: AC 005618176714 AC005618 human chromosome 5, BAC clone 249h5(LBNLH149), complete sequence. Human 36,27098-09-05 rxa 01261294 GB _ BA 1: CGLPD 1800Y 16642 Corynebacterium glutamicum lpd gene, the entire coding region. Corynebacterium glutamicum 100,00099-02-01

GB _ HTG 4: AC 010045164829 AC010045 Drosophila melanogaster chromosome 3L/75A1 clone RPCI98-17C17,^***sequencing of ongoing Drosophila melanogaster 50,5121999-10-16

In^***50 non-sequential fragments.

GB _ HTG 4: AC 010045164829 AC010045 Drosophila melanogaster chromosome 3L/75A1 clone RPCI98-17C17,^***sequencing of ongoing Drosophila melanogaster 50,5121999-10-16

In^***50 non-sequential fragments. rxa 01269564 GB _ BA 2: AF 12516426443 AF125164 bacteroides fragilis 638R polysaccharide B (PS B2) biosynthetic locus, complete sequence; andbacteroides fragilis (Bacteroides fragilis)56,0711999-12-01

An unknown gene.

GB _ BA 1: AB 00266824907 AB002668 Actinobacillus glycosyltransferase, lytic glycosyltransferase, dTDP-4-actinomyces rhamnosus (Actinobacillus 46,67998-02-21)

DNA for the sugar reductase, the entire coding region. actinomycetemeconitans)

GB _ BA 1: AB 01041523112 AB010415 with Actinomyces actinomycetemcomitans 6-deoxy-talan synthetic gene cluster, the entire coding region. Actinomyces actinomycetemcomitans 46,67999-02-13 rxa 012911056 GB _ STS: AU 027820238 AU027820 brown mouse, OTSUKA clone, OT78.02/918b07, microsatellite sequence, sequence tag brown mouse (Rattus norvegicus) 34,8741999-03-02

A site.

GB _ STS: AU 027820238 AU027820 brown mouse, OTSUKA clone, OT78.02/918b07, microsatellite sequence, sequence tag brown mouse 34,8741999-03-02

A site.

Table 4 (continuation)

GB _ HTG 3: chromosome 4 of AC 006445174547 AC006445 human,^***sequencing is in progress^***7 non-sequential fragments. Human 34,81299-09-15 rxa 012921308 GB _ BA 1: BSUB 0017217420Z 99120 bacillus subtilis complete genome (region 17/21): 3197001-3414420. Bacillus subtilis 37,80297-11-26

GB _ HTG 3: AC 010580121119 AC010580 Drosophila melanogaster No. 3 chromosome clone BACR48J06(D1102) RPCI-9848. J.6map Drosophila melanogaster 35,6371999-10-01

96F-96F strain y；cn bw sp，^***Sequencing is in progress^***71 out of sequence

And (3) fragment.

GB _ HTG 3: AC 010580121119 AC010580 Drosophila melanogaster No. 3 chromosome clone BACR48J06(D1102) RPCI-9848. J.6map Drosophila melanogaster 35,6371999-10-01

96F-96F strain y；cn bw sp，^***Sequencing is in progress^***71 out of sequence

And (3) fragment. rxa 01293450 GB _ GSS 8: AQ 001809705 AQ001809 CIT-HSP-2290D17.TF CIT-HSP human genome clone 2290D17, genome healed 42,02198-06-26

The sequence is described.

GB _ GSS 8:AQ 001809705 AQ001809 CIT-HSP-2290D17.TF CIT-HSP human genome clone 2290D17, genome healed 40,32398-06-26

The sequence is described. rxa 013391111 GB _ PL 1: MGU 602904614U 60290 Magaporthe grisea nitrogen-regulating protein (NUT1) gene, the entire coding region. Magnaporthe grisea 38,70796-07-03

GB _ HTG 3: AC 011371189187A C011371 human chromosome 5 clone CIT978SKB _107C20,^***human 39,7411999-10-06 in progress sequencing

^***31 non-sequential fragments.

GB _ HTG 3: AC 011371189187A C011371 human chromosome 5 clone CIT978SKB _107C20,^***human in progress sequencing 39,741 1999-10-06

^***31 non-sequential fragments. rxa 013821192 GB _ HTG 4: AC 009892138122 AC009892 human chromosome 19 clone CIT978SKB _83J4,^***sequencing is in progress^***. Human 40,1541999-10-31

6 sequential fragments.

GB _ HTG 4: AC 009892138122 AC009892 human chromosome 19 clone CIT978SKB _83J4,^***sequencing is in progress^***. Human 40,1541999-10-31

6 sequential fragments.

GB _ PR 3: AC 002416128915 AC002416 human X chromosome, complete sequence. Human 37,52198-01-29 rxa 013991142 GB _ EST 9: clone of mouse lung 937302 mouse cDNA of AA 096601524 AA096601 Mo03b09.r1 Stratagene mouse 40,52597-02-15

IMAGE: 5524735' and gb: L0650560S ribosomal protein L12 (human),

gb: l04280 mice ribosomal proteins (mouse) similar; mRNA

GB _ EST 37: AI 982114626 AI982114 Pat. pk0074.e9.f. Chicken activated T cell cDNA clone Pat. pk0074.e9.f. Chicken original chicken 37,78599-09-15

5', mRNA sequence similar to the B subunit of H-ATPase.

GB _ OV: GGU 207661645U 20766 chicken vacuole H + -ATPase B subunit gene, complete coding region. Chick 38,2441995-12-07 rxa 014201065 GB _ HTG 2: AC 005690193424 AC005690 human chromosome 4,^***sequencing is in progress^***7 non-sequential fragments. Human 37,46499-04-11

GB _ HTG 2: AC 005690193424 AC005690 human chromosome 4,^***sequencing is in progress^***7 non-sequential fragments. Human 37,46499-04-11

GB _ HTG 2: AC 00663722092 AC006637 Caenorhabditis elegans clone F41B4,^***sequencing is in progress^***1 Caenorhabditis elegans 37,48899-02-23

Is not smoothAnd (4) sequencing fragments. rxa 01467414 GB _ HTG 1: CEY102G 3110000 AL020985 Caenorhabditis elegans V chromosome clone Y102G3,^***sequencing of an ongoing Caenorhabditis elegans 35,43798-12-03

In _

GB _ HTG 1: CEY102G 3110000 AL020985 Caenorhabditis elegans V chromosome clone Y102G3,^***sequencing of an ongoing Caenorhabditis elegans 35,43798-12-03

In _

GB _ HTG 1: CEY113G 7110000 AL031113 Caenorhabditis elegans V chromosome clone Y113G7,^***sequencing of an ongoing Caenorhabditis elegans 35,43799-01-12

Rxa 01576882 GB _ BA 2: AF 0309752511 AF030975 Aeromonas salmonicida chaperone protein GroES and chaperone protein GroEL genes, complete coding Aeromonas salmonicida 41,51698-04-02

And (4) a zone. (Aeromonas salmonida) GB _ BA 2: AF 0309752511 AF030975 Aeromonas salmonicida chaperone protein GroES and chaperone protein GroEL genes, complete coding Aeromonas salmonicida 38,17198-04-02

And (4) a zone.

Table 4 (continuation)

GB _ EST 22: AI 068560965 AI068560 mgae0003aC11fMagnaporthe grisea stage cDNA library Pyricularia grisea 40,0731999-12-09

Pyricularia grisea cDNA clone mgae0003aC11f 5', mRNA sequence. rxa 01580840 GB _ GSS 14: AQ 554460681 AQ554460 RPCI-11-419F2.TVRPCI-11 human genome clone RPCI-11-419F2, genome human 36,5221999-05-28

Sequences are reviewed.

GB _ IN 2: AC 00544985518 AC005449 Drosophila melanogaster, chromosome 2R, region 44C4-44C5, clone DS 06765P 1, Drosophila melanogaster 36,6091998-12-23 intact

And (4) sequencing.

GB _ IN 2: AC 00544985518 AC005449 Drosophila melanogaster, chromosome 2R, region 44C4-44C5, clone DS 06765P 1, Drosophila melanogaster 33,6121998-12-23 intact

And (4) sequencing. rxa01584xa 01604771 GB _ HTG 3: AC 011352160167 AC011352 human chromosome 5 clone CIT-HSPC _327F10,^***sequencing is in progress^***Human 33,6881999-10-06

15 non-sequential fragments.

GB _ HTG 3: AC 011352160167 AC011352 human chromosome 5 clone CIT-HSPC _327F10,^***sequencing is in progress^***Human 33,6881999-10-06

15 non-sequential fragments.

GB _ HTG 3: AC 011402168868 AC011402 human chromosome 5 clone CIT978SKB _38B5,^***sequencing is in progress^***7 human 33,6881999-10-06

Non-sequential fragments. rxa 016141146 GB _ BA 1: CGA 2249462408 AJ224946 Corynebacterium glutamicum L-malic acid: DNA of quinone oxidoreductase. Corynebacterium glutamicum 42,28498-08-11

GB _ EST 17: AA 608825439 AA608825 af03g07.sl Soares _ testis _ NHT human cDNA clone IMAGE: 10306203' and homo sapiens 40,0921998-03-02

TR: G976083G976083 hisoneh 2A; the mRNA sequence.

GB _ PR 4: AC 005377102311 AC005377 human PAC clone DJ1136G02 from 7q32-q34, complete sequence. Human 37,81199-04-28 rxa 016291635 GB _ BA 1: CGPROPGE 2936Y 12537 Corynebacterium glutamicum proP Gene Corynebacterium glutamicum 100,00098-11-17

N

GB _ BA 1: CGPROPGE 2936Y 12537 Corynebacterium glutamicum proP Gene Corynebacterium glutamicum 100,00098-11-17

N

GB _ PR 4: AF 19107188481 AF191071 human chromosome 8 clone BAC 388D06, complete sequence. Human 35,6121999-10-11 rxa 016441401 GB _ BA 1: MSGB577C 37770L 01263 mycobacterium leprae genome dna sequence, cosmid b 577. Mycobacterium leprae 55,60496-06-14

OS

GB _ BA 1: MLCB 240735615 AL023596 mycobacterium leprae cosmid B2407. Mycobacterium leprae 36,41699-08-27

GB _ BA 1: MTV 025121125 AL022121 mycobacterium tuberculosis H37Rv complete genome; and a section 155/162. Mycobacterium tuberculosis 55,84499-06-24 rxa 016671329 GB _ BA 1: CGU 435363464U 43536 Corynebacterium glutamicum heat shock, ATP binding protein (clpB) gene, complete coding region, Corynebacterium glutamicum 100,0001997-03-13

GB _ HTG 4: AC 009841164434 AC009841 Drosophila melanogaster chromosome 3L/77E1 clone RPCI98-13F11,^***sequencing of ongoing Drosophila melanogaster 33,2051999-10-16

In^***70 non-sequential fragments.

GB_HTG4：AC009841 164434 AC009841 Drosophila melanogaster chromosome 3L/77E1 clone RPCI98-13F11,^***sequencing of ongoing Drosophila melanogaster 33,2051999-10-16

In^***70 non-sequential fragments. rxa 017221848 GB _ GSS 1: FR 0022586522 AL015452 f. rubipes GSS sequence, clone 077P23aB10, genome review sequence. Fugu rubripes 40,1921997-12-10

GB _ GSS 1: FR 0022584485 AL015450 f. rubipes GSS sequence, clone 077P23aB11, genome review sequence. Fugu rubripes 35,8761997-12-10

GB _ IN 1: CET26H 237569Z 82055 Caenorhabditis elegans cosmid T26H2, complete sequence. Caenorhabditis elegans 34,75999-11-19

TABLE 4 (continuation) rxa 017271401 GB _ BA2 Corynebacterium glutamicum β C-S lyase (aecD) and branched chain amino acid uptake vector (brnQ) based Corynebacterium glutamicum 99,92998-06-04

Thus, the entire coding region, and the putative protein Yhbw (yhbw) gene, part of the coding region.

GB _ HTG 6: AC 011037167849 AC011037 human clone RP11-7F18, WORKINGDRAFTSEQUENCE, 19 non-sequential pieces of human 36,90399-11-30

And (4) section.

GB _ HTG 6: AC 011037167849 AC011037 human clone RP11-7F18, WORKINGDRAFTSEQUENCE, 19 non-sequential pieces of human 35,64299-11-30

And (4) section. rxa 017371182 GB _ BA 1: SCGD 333779 AL096822 streptomyces coelicolor cosmid GD 3. Streptomyces coelicolor 38,05499-07-08

GB _ HTG 1: 14 chromosome clone R-976B16 of CNS01DSB 222193 AL121768,^***sequencing is in progress^***In the order of 35,1471999-10-05

And (3) fragment.

GB _ HTG 1: 14 chromosome clone R-976B16 of CNS01DSB 222193 AL121768,^***sequencing is in progress^***In the order of 35,1471999-10-05

And (3) fragment. rxa 017621659 GB _ BA 1: MTCI 2836300Z 97050 M.tuberculosis H37Rv complete genome; and a section 10/162. Mycobacterium tuberculosis 49,57498-06-23

GB _ BA 1: SC6G 1036734 AL049497 Streptomyces coelicolor cosmid 6G 10. Streptomyces coelicolor 44,049199903-24

GB _ BA 1: SCE 2926477 AL035707 streptomyces coelicolor cosmid E29. Streptomyces coelicolor 40,2461999-03-12 rxa 017641056 GB _ PL 2: SPAC 342947 AL109739 Schizosaccharomyces pombe I chromosome cosmid c 343. Schizosaccharomyces pombe 37,08499-09-06

(Schizosaccharomyces pombe)

GB _ PL 2: SPAC 342947 AL109739 Schizosaccharomyces pombe I chromosome cosmid c 343. Schizosaccharomyces pombe 34,89099-09-06 rxa 018011140 GB _ EST 38: AW 066306334 AW06630687009D03.yl 687-derived from early embryo cDNA of Delaware maize, mRNA sequence maize 46,1081999-10-12

And 6 columns.

GB _ GSS 13: AQ 484750375 AQ484750 RPCI-11-248N4 TV RPCI-11 human genome clone RPC1-11-248N4, genome human 32,0009904-24

Sequences are reviewed.

GB _ GSS 13: AQ 489971252 AQ489971 RPCI-11-247N23.TVRPCI-11 human genome clone RPCI-11-247N23, Gene human 36,11199-04-24

Group review sequences. rxa 01823900 GB _ BA 1: SCI 5140745 AL109848 Streptomyces coelicolor cosmid I51. Streptomyces coelicolor A3(2) 35,77999-08-16

GB _ BA 1: 9-12 minute genome sequence of ECU 82598136742U 82598 E.coli. Escherichia coli 39,21197-01-15

GB _ BA 1: BSUB 0018209510Z 99121 bacillus subtilis whole genome (region 18/21): 3399551-3609060. Bacillus subtilis 36,99997-11-26 rxa 01853675 GB _ BA 1: MTCY 22735946Z 77724 mycobacterium tuberculosis H37Rv complete genome; and a section 114/162. Mycobacterium tuberculosis 37,61298-06-17

GB _ HTG 3: AC 010189265962 AC010189 human clone RPCI11-296K13,^***sequencing is in progress^***80 non-sequential persons 39,00699-09-16

And (3) fragment.

GB _ HTG 3: AC 010189265962 AC010189 human clone RPCI11-296K13,^***sequencing is in progress^***80 non-sequential persons 39,00699-09-16

And (3) fragment. rxa 01881558 GB _ HTG 4: AC 011117148447 AC011117 human chromosome 4 clone 173_ C _09map 4,^***sequencing is in progress^***10 human 39,1301999-10-14

And (4) sequential fragments.

GB _ HTG 4: AC 011117148447 AC011117 human chromosome 4 clone 173_ C _09map 4,^***sequencing is in progress^***10 human 39,130 1999-10-14

And (4) sequential fragments.

GB _ BA 1: MTCY2B 1220431Z 81011M tuberculosis H37Rv complete genome; and a section 61/162. Mycobacterium tuberculosis 37,89398-06-18

Table 4 (continuous) rxa 01894978 GB _ BA 1: MTCY 27439991Z 74024 Mycobacterium tuberculosis H37Rv complete genome; and a section 128/162. Mycobacterium tuberculosis 37,22998-06-19

GB _ IN 1: CELF46H 538886U 41543 Caenorhabditis elegans cosmid F46H 5. Caenorhabditis elegans 38,52596-11-29

GB _ HTG 3: AC 009204115633 AC009204 Drosophila melanogaster No. 2 chromosome clone BACR03E19(D1033) RPCI-9803. E.19 Drosophila melanogaster 31,57999-08-18

map 36E-37C strainy；cn bw sp，^***Sequencing is in progress^***94 are not

And (5) sequencing the fragments. rxa 01897666 GB _ HTG 1: CEY48B 6293827 AL021151 Caenorhabditis elegans II chromosome clone Y48G6,^***sequencing is underway with Caenorhabditis elegans 34,70399-04-01

^***And are non-sequential fragments.

GB _ HTG 1: CEY48B 6293827 AL021151 Caenorhabditis elegans II chromosome clone Y48B6,^***sequencing is underway with Caenorhabditis elegans 34,70399-04-01

^***And are non-sequential fragments.

GB _ HTG 1: CEY53F 4-110000Z 92860 Caenorhabditis elegans II chromosomal clone Y53F4,^***sequencing is underway with Caenorhabditis elegans 33,33399-10-15

2^***And are non-sequential fragments. rxa 019461298 GB _ BA 1: MTV 00732806 AL021184 M.tuberculosis H37Rv complete genome; and a section 64/162. Mycobacterium tuberculosis 65,56098-06-17

GB _ BA 1: SC5F2A 40105 AL049587 Streptomyces coelicolor cosmid 5F 2A. Streptomyces coelicolor 50,6481999-05-24

GB _ BA 1: SCARD1GN 2321X 84374 Streptomyces sp ard1 gene. Streptomyces entwiniae 44,97395-08-23 rxa 01980756 GB _ PL 2: AC 00826299698 AC008262 the genomic sequence, complete sequence, of arabidopsis BACF4N2 from chromosome 1. Arabidopsis thaliana 35,31099-08-21

GB _ PL 1: AB 01338873428 AB013388 arabidopsis genomic DNA, chromosome 5, TAC clone: K19E1, complete sequence. Arabidopsis thaliana 35,50599-11-20

GB _ PL 1: AB 01338873428 AB013388 arabidopsis genomic DNA, chromosome 5, TAC clone: K19E1, complete sequence. Arabidopsis 39,97399-11-20 rxa 01983630 GB _ HTG 4: AC 006467175695 AC006467 drosophila melanogaster No. 2 chromosome clone BACR03L08(D532) RPCI-9803.L.8map drosophila melanogaster 36,6721999-10-27

40A-40C strain y；cn bw sp，^***Sequencing is in progress^***9 out of sequence

And (3) fragment.

GB _ HTG 4: AC 006467175695 AC006467 drosophila melanogaster No. 2 chromosome clone BACR03L08(D532) RPCI-9803.L.8map drosophila melanogaster 36,6721999-10-27

40A-40C strain y；cn bw sp，^***Sequencing is in progress^***9 out of sequence

And (3) fragment.

GB _ HTG 4: AC 006467175695 AC006467 drosophila melanogaster No. 2 chromosome clone BACR03L08(D532) RPCI-9803.L.8map drosophila melanogaster 32,3671999-10-27

40A-40C strain y；cn bw sp，^***Sequencing is in progress^***9 out of sequence

And (3) fragment. rxa 020201111 GB _ BA 1: CGDNAARO 2612X 85965 Corynebacterium glutamicum ORF3 and aroP genes. Corynebacterium glutamicum 100,00097-11-30

P

GB _ PAT: A588871612A 58887 is obtained from sequence 1 of patent WO 9701637. Unidentified 100,0001998-03-06

GB _ BA 1: STYCARAB 4378M 95047 Salmonella typhimurium transporter, complete coding region and transfer RNA-Arg. Salmonella typhimurium 50,5471996-03-13

A (Salmonella typhimurium) rxa 020291437 GB _ HTG 2: AC 003023768 AC003023 human chromosome 11 clone pDJ363p2,^***sequencing is in progress^***22 non-human 35,8201997-10-21

And (5) sequencing the fragments.

GB _ HTG 2: AC 003023768 AC003023 human chromosome 11 clone pDJ363p2,^***sequencing is in progress^***22 non-human 35,8201997-10-21

And (5) sequencing the fragments.

GB _ HTG 2: HS118B 18104729 AL034344 human chromosome 6 clone RP1-118 B18map24.1-25.3,^***sequencing is ongoingHuman 34,3551999-12-03

In the middle of^***And are non-sequential fragments.

Table 4 (continuation) rxa 020301509 GB _ PR 4: AC 00769563247 AC007695 human 12q24BACRPCI11-124N23(Roswell Park Cancer Institute human BAC human 38,68199-09-01

Library) the complete sequence.

GB _ PR 4: AC 00646499908 AC006464 human BAC clone from 2 NH0436C12, complete sequence human 35,4451999-10-22

GB _ PR 4: AC 00646499908 AC006464 human BAC clone NH0436C12 from 2, complete sequence human 35,9681999-10-22 rxa 020731653 GB _ BA 1: CGGDHA 2037X 72855 Corynebacterium glutamicum GDHA Gene Corynebacterium glutamicum 39,6551993-05-24

GB _ BA 1: CGGDH 2037X 59404 Corynebacterium glutamicum, the gdh gene of glutamate dehydrogenase Corynebacterium glutamicum 44,44499-07-30

GB _ BA 2: SC2H 425970 AL031514 Streptomyces coelicolor cosmid 2H 4. Streptomyces coelicolor A3(2) 38,4521999-10-19 rxa02074 020 02074rxa 020951527 GB _ EST 18: AA 703380471 AA703380 zj12b06.sl Soares _ total-lever _ spread _1NFLS _ S1 human cDNA clone human 36,5181997-12-24

IMAGE: 4500353', similar to the one containing the repeat element LTR5.t3 LTR 5; mRNA

And (4) sequencing.

GB _ HTG 6: AC 009769122911 AC009769 human chromosome 8 clone RP11-202I12map 8, Low PASS sequence sampling (LOW-PASS human 35,4731999-12-07)

SEQUENCE SAMPLING)。

GB _ EST 7: W70175436W 70175 zd52c02.rl Soares _ total _ heart _ NbHH19W human cDNA clone human 34,1741996-10-16

IMAGE: 3442585', the homologue contains the LTR5b2LTR5 repeat element; mRNA

And (4) sequencing. rxa 02099373 GB _ BA 1: CAJ 103195368 AJ010319 Corynebacterium glutamicum amtP, glnB, glnD gene and part of ftsY and srp gene. Corynebacterium glutamicum 100,0001999-05-14

GB _ HTG 3: chromosome number AC 011509111353 AC 01150919 clone CITB-H1_2189E23,^***human 33,4231999-10-07 in progress

^***35 non-sequential fragments.

GB _ HTG 3: AC 011509111353 AC011509 human chromosome 19 clone CITB-H1_2189E23,^***human 33,4231999-10-07 in progress

^***35 non-sequential fragments. rxa 021151197 GB _ HTG 5: AC 010126175986 AC010126 human clone GS502B02,^***sequencing is in progress^***3 non-sequential fragments. Human 36,71799-11-13

GB _ HTG 5: AC 010126175986 AC010126 human clone GS502B02,^***sequencing is in progress^***3 non-sequential fragments. Human 36,09299-11-13

GB _ PR 1: HUMHM 1452214D 10925 mRNA from human HM 145. Human 39,17199-02-03 rxa 021281818 GB _ BA 1: MTCY 19034150Z 70283 mycobacterium tuberculosis H37Rv complete genome; and a section 98/162. Mycobacterium tuberculosis 38,68298-06-17

GB _ BA 1: MTCY 19034150Z 70283 mycobacterium tuberculosis H37Rv complete genome; and a section 98/162. Mycobacterium tuberculosis 35,74698-06-17

GB _ GSS 10: AQ 161109738 AQ161109 nbxb0006D03rCUGI Rice BAC library rice genomic clone nbxb0006D03 r. Rice 38,48298-09-12

Genome review sequences. rxa 02133329 GB _ BA 2: MPAE 0000528530 AE000058 region 58/63 of the complete genome of mycoplasma pneumoniae. Mycoplasma pneumoniae 32,31796-11-18

8 (Mycoplasma pneumoniae)

GB _ HTG 4: clone BACR10M16(D743) RPCI-9810.M.16 Drosophila melanogaster 34,5791999-10-20 of chromosome 3 of AC 008308151373 AC008308 Drosophila melanogaster

map93C-93D strain y；cnbwsp，^***Sequencing is in progress^***186 ones

Non-sequential fragments.

Table 4 (continuation)

GB _ HTG 4: clone BACR10M16(D743) RPCI-9810.M.16 Drosophila melanogaster 34,5791999-10-20 of chromosome 3 of AC 008308151373 AC008308 Drosophila melanogaster

map93C-93D strainy；cnbwsp，^***Sequencing is in progress^***186 ones

Non-sequential fragments. rxa 02150924 GB _ EST 37: AW 012260358 AW01226 um06e09.yl Sugano mouse kidney mkia mouse cDNA clone IMAGE: 2182312 little mouse 39,38599-09-10

05', and SW: AMPL _ BOVINP00727 cytoplasmic aminopeptidase was similar; mRNA sequences

And (4) columns.

GB _ GSS 3: b87734192218 AC005042 RPCI11-30D24. TPRPPCI-11 human genome clone RPCI-11-30D24, genome human 37,62999-04-09

Sequences are reviewed.

GB _ PR 4: AC 005042389B 87734 human clone NH0552E01, complete sequence. Human 36,90199-01-14 rxa 021711776 GB _ BA 2: AF 010496189370 AF010496 rhodobacter membranaceus strain SB1003, partial genome. Rhodobacterium included 53,7141998-05-12

GB _ EST 24: AI 170522367 AI170522 EST216450 normalizes rat lungs, and Bento Soares mouse (Rattus sp.) cDNA clone mouse (Rattus sp.) 44,18699-01-20

RLUCO 753' end, mRNA sequence.

GB _ PL 1: PHVDLECA 1441K 03288A phaseolus vulgaris lectin gene encoding hemagglutinin (PHA-E), Phaseolus vulgaris 39,10393-04-27

And (4) a whole coding area. rxa 021731575 GB _ BA 1: glt gene and ORF of citrate synthase from CGGLTG 3013X 66112 Corynebacterium glutamicum. Corynebacterium glutamicum 44,11895-02-17

GB _ BA 1: glt gene and ORF of citrate synthase from CGGLTG 3013X 66112 Corynebacterium glutamicum. Corynebacterium glutamicum 36,18995-02-17

GB _ BA 2: AE 00010410146 AE000104 plasmid pNGR234a of rhizobium NGR 234. Region 41/46 of the complete plasmid sequence. Rhizobia (Rhizobium sp.) NGR 23438,4871997-12-12 rxa 022241920 GB _ BA 2: CXU 213008990U 21300 Corynebacterium striatum putative protein YbhB gene, partial coding region; ABC transporter corynebacterium striatum 37,26499-04-09

Tetb (tetb), ABC transporter teta (teta), transposase, 23SrRNA methyl (Corynebacterium strain)

Transferase and transposase genes, complete coding regions; and unknown genes.

GB _ HTG 3: AC 00918587184 AC009185 human chromosome 5 clone CIT-HSPC _248O19,^***sequencing is in progress^***Human 36,4591999-10-07

2 sequential fragments.

GB _ HTG 3: AC 00918587184 AC009185 human chromosome 5 clone CIT-HSPC _248O19,^***sequencing is being performedIn process of^***Human 36,4591999-10-07

2 sequential fragments. rxa 02225905 GB _ BA 2: MPAE 0000528530 AE000058 region 58/63 of the complete genome of mycoplasma pneumoniae. Mycoplasma pneumoniae 35,49896-11-18

8

GB _ EST 26: AI 337275618 AI337275 tb96h11.x1 NCI _ CGAP _ Co16 human cDNA clone IMAGE: 20622453' and man 35,5891999-03-18

TR: q15392ORF was similar, the entire coding region; the mRNA sequence.

GB _ EST 26: AI 337275618 AI337275 tb96h11.x1 NCI _ CGAP _ Co16 human cDNA clone IMAGE: 20622453' and man 42,7861999-03-18

TR: q15392ORF was similar, the entire coding region; the mRNA sequence. rxa 022331410 GB _ BA 1: ERWPNLB 1291M 65057 Erwinia carotovora pectin lyase (Hnl) gene, the entire coding region. Erwinia carotovora 37,78093-04-26

(Erwinia carotovora)

GB _ EST 30: AV 021947313 AV021947 AV 02194947 mouse 18 day embryo C57BL/6J mouse cDNA clone mouse 39,42399-08-28

1190024M23, mRNA sequence.

GB _ EST 33: AV 087117251 AV087117 AV087117 Mucuna caudatum tongue C57BL/6J adult Mucuna cauda cDNA clone Mucuna cauda 47,41099-06-25

2310028C15, mRNA sequence. rxa 022531050 GB _ EST 11: AA 250210532 AA250210 mx79g10.r1 Soarl mouse NML mouse cDNA clone IMAGE: 6926105', mus musculus 36,1361997-03-12

And TR: E236517E236517F44G4.1 are similar; the mRNA sequence.

GB _ EST 11: AA 250210532 AA250210 mx79g10r1Soares mouse NML mouse cDNA clone IMAGE: 6926105', mus musculus 36,2021997-03-12

And TR: E236517E236517F44G4.1 are similar; the mRNA sequence.

Table 4 (continuation) rxa 022611479 GB _ BA 1: CGL 0077324460 AJ007732 Corynebacterium glutamicum 3 'ppc gene, secG gene, amt gene, ocd gene and 5' soxA Corynebacterium glutamicum 100,00099-01-07

A gene.

GB _ BA 1: CGAMTGEN 2028X 93513 Corynebacterium glutamicum amt gene. Corynebacterium glutamicum 100,0001996-05-29

E

GB _ BA 1: CORPEPC 4885M 25819 C.glutamicum phosphoenolpyruvate carboxylase gene, the entire coding region. Corynebacterium glutamicum 100,0001995-12-15 rxa 022681023 GB _ PL 2: AF 0871303478 AF087130 Neurospora crassa siderophore regulatory protein (sre) gene, the entire coding region. Neurospora crassa 39,2681998-10-22

GB _ EST 30: AI 663709408 AI663709 ud47a06.yl Soares mouse mammary gland NbMMG mus musculus cDNA clone mus 41,5231999-05-10

IMAGE: 14490105', and TR: o75585 mitogen activation and sympathetic activation

Chemoattractant kinase-2; the mRNA sequence.

GB _ RO: AF 0747143120 AF074714 mouse mitogen-activated and stress-activated protein kinase-2 (mMSK2) mouse 38,3471998-10-24

mRNA, entire coding region. rxa 022691095 GB _ GSS 4: AQ 742825847 AQ742825 HS _5482_ B2_ A04_ T7APCRI-11 human male BAC library human genome clone human 37.70399-07-16

Panel 1058 column 8 row B, genome overview sequence.

GB _ HTG 3: AC 009293162944 AC009293 chromosome 18 clone 53_ I _06map18,^***sequencing is in progress^***15 human 37,00699-08-13

Non-sequential fragments.

GB _ HTG 3: AC 009293162944 AC009293 chromosome 18 clone 53_ I _06map18,^***sequencing is in progress^***15, people 37,006 99-08-13

Non-sequential fragments. rxa 023091173 GB _ BA 1: MTY25D 1040838Z 95558 M.tuberculosis H37Rv complete genome; and a section 28/162. Mycobacterium tuberculosis 52,34498-06-17

GB _ BA 1: MSGY 22440051 AD000004 is from the mycobacterium tuberculosis sequence of clone y 224. Mycobacterium tuberculosis 52,3441996-12-03

GB _ HTG 2: AC 007163186618 AC007163 human clone NH0091M05,^***sequencing is in progress^***1 non-sequential fragment. Human 37,26399-04-23 rxa 023101386 GB _ BA 1: MTY25D 1040838Z 95558 M.tuberculosis H37Rv complete genome; and a section 28/162. Mycobacterium tuberculosis 36,86198-06-17

GB _ BA 1: MSGY 22440051 AD000004 is from the mycobacterium tuberculosis sequence of clone y 224. Mycobacterium tuberculosis 36,8611996-12-03

GB _ PR 3: HS279N 11169998Z 98255 comes from the human DNA sequence on chromosome Xq11.2-133 of PAC279N 11. Human 34,51699-11-23 rxa 023211752 GB _ BA 1: AB 0185314961 AB018531 Corynebacterium glutamicum dtsR1 and dtsR2 genes, the entire coding region. Corynebacterium glutamicum 99,0301998-10-19

GB _ PAT: E170194961E 17019 Brevibacterium lactofermentum dtsR and dtsR2 genes. Corynebacterium glutamicum 98,97399-07-28

GB _ BA 1: AB 0185302855 AB018530 Corynebacterium glutamicum dtsR gene. The entire coding region. Corynebacterium glutamicum 99,0301998-10-19 rxa 023351896 GB _ BA 1: CGU 350233195U 35023 Corynebacterium glutamicum thiothiosulfatase (thtR) gene, partial coding region, acyl CoA Corynebacterium glutamicum 99,94797-01-16

Carboxylase (accBC) gene, complete coding region.

GB _ BA 1: U0001233312U 00012 M.leprae cosmid B1308. Mycobacterium leprae 40,24796-01-30

GB _ BA 1: MTCY 7142729Z 92771 Mycobacterium tuberculosis H37Rv complete genome; and a section 141/162. Mycobacterium tuberculosis 67,56899-02-10 rxa 02364750 GB _ BA 1: AP 000006319000 AP00006 Pyrococcus horikoshiiOT3 genomic DNA, 1166001-1485000nt. position Pyrococcus horikoshii 36,13099-02-08

(6/7)。

GB _ BA 1: AP 000006319000 AP00006 Pyrococcus horikoshiiOT3 genomic DNA, 1166001-1485000nt. position Pyrococcus horikoshii 34,54399-02-08

(6/7)。

Table 4 (continuation) rxa 023722010 GB _ HTG 3: AC 011461100974 AC011461 clone CIT-HSPC _429L19 human chromosome 19,^***human 36,1381999-10-07 in progress

^***4 sequential fragments.

GB _ HTG 3: AC 011461100974 AC011461 clone CIT-HSPC _429L19 human chromosome 19,^***human 36,1381999-10-07 in progress

^***4 sequential fragments.

GB _ EST 21: AA 992021279 AA992021 ot36c01.s 1Soares _ testis _ MHT human cDNA clone IMAGE: 16188483', human 41,21998-06-03

The mRNA sequence. rxa 023971119 GB _ HTG 4: AC 00927376175 AC009273 Arabidopsis thaliana chromosome 1 clone T1N6,^***sequencing is in progress^***2 pieces of cis Arabidopsis 38,5661999-10-12

And (4) sequencing fragments.

GB _ HTG 4: AC 00927376175 AC009273 Arabidopsis thaliana chromosome 1 clone T1N6,^***sequencing is in progress^***2 pieces of cis Arabidopsis 38,5661999-10-12

And (4) sequencing fragments.

GB _ BA 1: D9082619493D 90826 E.coli genomic DNA, Kohara clone #335(40.9-41.3 min). Escherichia coli 39,6001997-03-21 rxa 02424723 GB _ EST 13: AA 334108275 AA334108 EST38262 embryo, 5' end of human cDNA at 9 weeks, mRNA sequence. Human 38,60397-04-21

GB _ PR 3: AC 005224166687 AC005224 human chromosome 17, clone hrpk.214_ O _1, complete sequence. Human 36,11198-08-14

GB _ PR 3: AC 005224166687 AC005224 human chromosome 17, clone hrpk.214_ O _1, complete sequence. Human 33,42798-08-14 rxa 024261656 GB _ PAT: A066641350A 06664 Bacillus stearothermophilus lct gene. Bacillus stearothermophilus (Bacillus 39,93693-07-29)

stearothermophilus)

GB _ PAT: A041151361A 04115 Bacillus stearothermophilus recombined lct gene. Synthetic construct 40,04297-02-17

GB _ BA 1: BACLDHL 1361M 14788 Bacillus stearothermophilus encodes lct gene for L-lactate dehydrogenase, the entire coding region. Bacillus stearothermophilus 40,33893-04-26 rxa 024871827 GB _ BA 2: AF 00710132870 AF007101 S.hygroscopicus putative pteridine-dependent dioxygenase, PKS modules 1,2, 3 and 4 S.hygroscopicus 43,29898-01-13

And the entire coding region of the putative regulatory protein gene and the putative hydroxylase gene part (Streptomyces hygroscopicus)

And (5) dividing coding areas.

GB _ BA 1: MTCI 36429540Z 93777 Mycobacterium tuberculosis H37Rv complete genome; and a section 52/162. Mycobacterium tuberculosis 44,35298-06-17

GB _ BA 2: AF 11962115986 AF119621 Pseudomonas abiporia BKME-9DitI (ditI), dioxygenase DitA oxygenase Pseudomonas abiporia 43,61199-04-28

Small subunit (ditA2), dioxygenase DitA oxygenase component large subunit (ditAl), DitH

(ditH)、DitG(ditG)、DitF(ditF)、DitR(ditR)、DitE(ditE)、DitD(ditD)、

Aromatic diterpenoid compounds such as outer diol (extradiol) cyclocleavage dioxygenase (ditC), DitB

(ditB) and the dioxygenase DitA ferredoxin component (DitA3) genes, the entire coding region;

and unknown genes rxa 02511780 GB _ PR 4: the BCRL2-GGT region of AC 002470235395 AC002470 human chromosome 22q11.2bac clone b135h6, complete sequence. Human 37,97199-11-30

GB _ PR 4: AC 002472147100 AC002472 human chromosome 22q11.2pac clone p _ n5 BCRL2-GGT region, complete sequence. Human 38,23999-09-13

GB _ EST 34: AI 806938118 AI806938 wf24b07.x1 soures _ NFL _ T _ GBC _ S1 human cDNA clone IMAGE: 2356501 human 38,98399-07

3', and SW: PLZF _ HUMAN Q05516 zinc finger protein PLZF is similar; mRNA sequences

And (4) columns. rxa 025121086 GB _ BA 1: MTCY1A 1025949Z 95387 Mycobacterium tuberculosis H37Rv complete genome; and a section 117/162. Mycobacterium tuberculosis 37,40798-06-17

GB _ BA 1: MLCL 58136225Z 96801 M.leprae cosmid L581. Mycobacterium leprae 43,19397-06-24

GB _ OV: GGU 433962738U 43396 native chicken tropomyosin receptor kinase A (ctrkA) mRNA, the entire coding region. Chick 38,78996-01-18 rxa 025271452 GB _ BA 2: AF 008220220060 AF008220 Bacillus subtilis nmB-dnaB genomic region. Bacillus subtilis 37,39598-02-04

Table 4 (continuation)

GB _ BA 2: AF 008220220060 AF008220 Bacillus subtilis rmB-dnaB genomic region. Bacillus subtilis 36,21898-02-04

GB _ HTG 2: AC 005861112369 AC005861 Arabidopsis thaliana clone F23B24,^***sequencing is in progress^***6 non-sequential fragments. Arabidopsis 38,40799-04-29 rxa 025472262 GB _ PL 1: AB 0065307344 AB006530 Sat gene of watermelon serine acetyltransferase, complete coding region and 5' flanking region. Watermelon (Citrulluslanatus) 35,44997-08-20

GB _ PL 1: (Sat) DNA of CNASA 5729D 85624 serine acetyltransferase from watermelon (Citrullus vulgaris) which completely encodes 35,44999-02-06

And (4) a zone.

GB _ PL 1: AB 0065307344 AB006530 Sat gene of watermelon serine acetyltransferase, complete coding region and 5' flanking region. Watermelon (Citrullluslanatus) 34,64697-08-20 rxa 025661332 GB _ EST 32: AI 727189619 AI727189 BNLGHi 74986 day cotton cellucotton and (AB020715) KIAA0908 protein upland cotton (Gossypium hirsutum) 35,09999-06-11

[ human]similar cDNA 5', mRNA sequence.

GB _ BA 1: CGPUTP 3791Y 09163 Corynebacterium glutamicum putP gene. Corynebacterium glutamicum 38,56297-09-08

GB _ PL 2: SPAC13G 633481Z 54308 Schizosaccharomyces pombe I chromosome cosmid c13G 6. Schizosaccharomyces pombe 35,7741999-10-18 rxa 025711152 GB _ BA 1: CGU 435352531U 43535 Corynebacterium glutamicum multiple drug resistance protein (cmr) gene, complete coding region. Corynebacterium glutamicum 41,87297-04-09

GB _ EST 35: AI 857385488 AI857385 w155e03.x1 NCI _ CGAP _ Brn25 human cDNA clone IMAGE: 24288283', human 39,13999-08-26

The mRNA sequence.

GB _ BA 1:CGU 435352531U 43535 Corynebacterium glutamicum multiple drug resistance protein (cmr) gene, complete coding region. Corynebacterium glutamicum 38,55297-04-09 rxa 025781227 GB _ PL 1: AB 01687179109 AB016871 arabidopsis genomic DNA, chromosome 5, TAC clone: K16L22, complete sequence. Arabidopsis thaliana 34,21399-11-20

GB _ PL 1: AB 02560255790 AB025602 arabidopsis genomic DNA, chromosome 5, BAC clone: f14a1, complete sequence. Arabidopsis thaliana 36,46199-11-20

GB _ IN 1: CELF36H 935985 AF016668 Caenorhabditis elegans cosmid F36H 9. Caenorhabditis elegans 35,97797-08-08 rxa 025811983 GB _ BA 1: MTV 00537840 AL010186 M.tuberculosis H37Rv complete genome; and a section 51/162. Mycobacterium tuberculosis 38,51798-06-17

GB _ BA 1: MTV 00537840 AL010186 M.tuberculosis H37Rv complete genome; and a section 51/162. Mycobacterium tuberculosis 39,17398-06-17 rxa 025824953 GB _ BA 1: MTV 02623740 AL022076 M.tuberculosis H37Rv complete genome; and a section 157/162. Mycobacterium tuberculosis 38,54899-06-24

GB _ BA 1: MTCY 33829372Z 74697 Mycobacterium tuberculosis H37Rv complete genome; and a section 127/162. Mycobacterium tuberculosis 46,26398-06-17

GB _ BA 1: the eryA gene of 6-deoxyerythronolyde B synthases II and III of Saccharopolyspora erythraea, SEERYABS 20444X 62569. Saccharopolyspora erythraea 45,05392-02-28

(Saccharomyces erythraea) rxa 025831671 GB _ BA 2: AF 1136051593 AF113605 streptomyces coelicolor propionyl-CoA carboxylase complex B subunit (pccB) gene, and the complete coding streptomyces coelicolor 58,3971999-12-08

And (5) code area.

GB _ BA 1: SC1C 242210 AL031124 Streptomyces coelicolor cosmid 1C 2. Streptomyces coelicolor 52,91699-01-15

GB _ BA 1: AB 0185314961 AB018531 Corynebacterium glutamicum dtsR1 and dtsR2 genes, the entire coding region. Corynebacterium glutamicum 58,8091998-10-19 rxa 02599600 GB _ BA 1: AEMML 2585X 99639 Ralstonia eutropha mmlH, mmlI and mmlJ genes. Ralstonia eutropha 35,26498-01-22

Table 4 (continuation)

GB _ EST 15: AA 508926422 AA508926 MBAFCW1C8T3 Malaria feminium imago cDNA (SAW96MLW-BmAF) Malaria malayi (Brugia malayi) 43,37797-07-08

The filarial cDNA clone AFCw1C 085', mRNA sequence.

GB _ BA 1: AEMML 2585X 99639 Ralstonia eutropha mmlH, mmlI and mmlJ genes. Ralstonia eutropha 41,14898-01-22 rxa 026341734 GB _ BA 1: NDhC, psbG gene and ORF157 of SYNPOO 1964X 17439 Synechocystis NDH-C, PSII-G. Synechocystis PCC 680338,14599-02-10

GB _ GSS 9: AQ 101527184 AQ101527 HS _2265_ AL _ E11_ MF CIT approved human genome sperm library D human genome human 38,79898-08-27

Clone plate column 2265 line 21 line I, genome overview sequence.

GB _ IN 1: MNE 133341399 AJ133341 Melahaphe neritoides part caM gene, exons 1-2. Melahaphe neritoides 39,09899-06-02 rxa 02638999 GB _ BA 2: AE 00175610938 AE001756 region 68/136 of the complete genome of Thermotoga maritima. Thermotoga maritima 40,10499-06-02

GB _ GSS 12: AQ 423878689 AQ423878 CITBI-E1-2575E20.TF CITBI-E1 human genome clone 2575E20, genome synthesis human 36,4511999-03-23

The sequence is described.

GB _ HTG 2: AC 006765274498 AC006765 Caenorhabditis elegans clone Y43H11,^***sequencing is in progress^***，7 Caenorhabditis elegans 39,072 99-02-23

Non-sequential fragments. rxa 02659335 GB _ EST 36: cloning of genomic System from AI 900317436 AI900317 sc04a02.y1 Gm-c1012 Soybean cDNA clone (GENOME Soybean (Glycinemax) 41,5661999-12-06

System CLONE) ID: gm-c 1012-11555', and SW: PRS6 SOLTU

P5477826S protease regulatory subunit 6B homologs; the mRNA sequence.

GB _ GSS 12: AQ 342831683 AQ342831 RPCI11-122K17.TJ RPCI-11 human genome clone RPCI-11-122K17, gene human 34,7621999-05-07

Group review sequences.

GB _ EST 36: AI 900856779 AI900856 sb95c11.yl Gm-c1012 Soybean cDNA clone genomic System clone ID: Gm-Glycine max 39,0631999-12-06

c 1012-4295', and SW: PRS6_ SOLTUP 5477826S protease regulatory subunit 6B

Homologues are similar; the mRNA sequence. rxa 026761512 GB _ IN 2: CELB 021339134 AF039050 Caenorhabditis elegans cosmid strain B0213. Caenorhabditis elegans 35,81499-06-02

GB _ GSS 1: arabidopsis gene Arabidopsis 38,46299-06-28 with CNS00PZB 364 AL085157 from IGF library BACF10D11 of Arabidopsis thaliana Columbia strain

Group review sequence end SP6, genome review sequence.

GB _ RO: RNITPR2R 10708X 61677 ITPR2 gene of rat type 2 inositol triphosphate receptor. Brown mouse 37,5431991-10-21 rxa 02677882 GB _ RO: mRNA of D897285002D 89728 mouse LOK, the entire coding region. Little mouse 38,82999-02-07

GB _ GSS 8: AQ 062004362 AQ062004 CIT-HSP-2346O14.TRCIT-HSP human genome clone 2346O14, genome integrated 36,56598-07-31

The sequence is described.

GB _ GSS 14: AQ 555818462 AQ555818 HS _5230_ B1_ G06_ SP6ERPCI-11 human Male BAC library human genome clone human 36,5341999-05-29

Panel 806 line 11 line N, genome overview sequence. rxa 02691930 GB _ IN 1: DME 97367411 AJ009736 Drosophila melanogaster Idefix reverse transcription element (retroelement): gag, pol and env genes, Drosophila melanogaster 36,52299-01-19

In part.

GB _ PR 4: AC 004801193561 AC004801 human 12q13.1PACRPCI1-228P16(Roswell Park cancer institute human 39,34199-02)

PAC library) complete sequence.

GB _ PR 4: AC 004801193561 AC004801 human 12q13.1PACRPCI1-228P16(Roswell Park cancer institute human 37,03799-02)

PAC library) complete sequence. rxa 027181170 GB _ EST 34: cloning of mouse 43,52999-07-01 from AV 132028258 AV132028 AV 132028C 57BL/6J 11 day embryo mouse cDNA

2700087F01, mRNA sequence.

GB _ GSS 10: AQ 240654452 AQ240654 CIT-HSP-2385D24.TFB.1 CIT-HSP human genome clone 2385D24, genome human 40,04498-09-30

Sequences are reviewed.

GB _ GSS 11: AQ 309500576 AQ309500 CIT-HSP-2384D24.TFD CIT-HSP human genome clone 2384D24, genome integrated 38,8691998-12-22.

Table 4 (continuation) rxa 02749999 GB _ BA 2: AF 08679137867 AF086791 ZM4 clone 67E10 carbamyl phosphate synthetase small subunit ZM 39,02498-11-04

(carA), carbamoyl phosphate synthetase large subunit (carB), transcription elongation factor (greA), alkene (Zymomonasmobilis)

An alcoholate (eno), a pyruvate dehydrogenase α subunit (pdhA), a pyruvate deaminase β subunit

(pdhB), ribonuclease H (mh), homoserine kinase homolog, alcohol dehydrogenase II

(adhB) and exonuclease (exclusinuclear) ABC subunit A (uvrA) genes, completely encoded

A code region; and unknown genes.

GB _ BA 1: SYCSLRB 146271D 64000 Synechocystis sp. PCC6803 complete genome, 19/27, 2392729-2538999. Synechocystis sp. 34.57399-02-13

GB _ BA 2: AE 00130613316 AE001306 region 33/87 of the complete genome of chlamydia trachomatis. Chlamydia trachomatis 38,94098-09-02

(Chlamydia trachomatis) rxa 02767906 GB _ BA 2: AF 1269531638 AF126953 c.glutamicum cystathionine gamma synthase (metB) gene, complete coding region. Corynebacterium glutamicum 100,00099-09-10

GB _ BA 1: SCI 56661 AL079332 Streptomyces coelicolor cosmid I5. Streptomyces coelicolor 37,48699-06-16

GB _ PR 3: HS90L 6190837Z 97353 is derived from the human DNA sequence on chromosome 22q11.21-11.23 of clone 90L 6. Human 34,14999-11-23

Has one RPL15(60S ribosomal protein L15) pseudogene, EST, STS and GSS,

the complete sequence. rxa 02792876 GB _ BA 2: AF 0990155000 AF099015 Streptomyces coelicolor strain A3(2) integrase (int), iron-containing superoxide dismutase II Streptomyces coelicolor 36,72199-06-01

(sodF2), iron uptake system permease (ftrE) and iron uptake system integral membrane protein (ftrD) base

Thus, the coding region is intact.

GB _ BA 1: ECOUW 93338534U 14003 Escherichia coli K-12 chromosome region at 92.8-00.1 minutes. Escherichia coli 38,78796-04-17

GB _ HTG 3: AC 011361186148 AC011361 human chromosome 5 clone CIT-HSPC _482N19,^***sequencing is in progress^***Human 43.5771999-10-06

69 non-sequential fragments. rxa 027941197 GB _ PR 4: AC 00599896556 AC005998 human clone DJ0622E21, complete sequence. Human 37,29899-07-29

GB _ PR 4: AC 00600857554 AC006008 human clone DJ0820a21, complete sequence. Human 36,63899-06-17

GB _ PR 3: HSDJ73H 1495556 AL080272 human DNA sequence on chromosome Xq26.3-28 from clone 73H14, complete human 39,72699-11-23

And (4) columns. rxa 02809375 GB _ RO: MUSSPCTLT 3172M 22527 mouse cytotoxic T lymphocyte specific serine protease CCPII Gene, Whole mouse 47,51896-01-19

In (1).

GB _ RO: MUSGRC 894M 18459 mouse granzyme C serine esterase mRNA, the entire coding region. Little mouse 44,93993-06-12

GB _ RO: RNU 57062880U 57062 brown mouse natural killer cell protease 4(RNKP-4) mRNA, the entire coding region. Brown mouse 41,55496-07-31 rxa 02811484 GB _ GSS 6: AQ 832862476 AQ832862 HS _5261_ A2_ E10_ SP6E RPCI-11 human Male BAC library human genome clone human 35,61099-08-27

Panel 837 column 20 row I, genome overview sequence.

GB _ GSS 5: AQ 784593515 AQ784593 HS _3248_ A2F 02_ T7C CIT approved human genome sperm library D human gene human 38,95699-08-03

Panel cloning plate 3248 column 4 row K, genome overview sequence.

GBB _ GSS 13: AQ 47314397 AQ473140 CITBI-E1-2589G6.TF CITBI-E1 human genome clone 2589G6, genome review human 34,76199-04-23

0 sequence. rxa 02836678 GB _ EST 18: AA 696785316 AA696785 GM08392.5prime GM Drosophila melanogaster ovary BlueScript Drosophila melanogaster cDNA clone Drosophila melanogaster 40,60498-11-28

GM 083925 prime, mRNA sequence.

GB _ EST 18: AA 696785316 AA696785 GM08392.5PrimeGM Drosophila melanogaster ovary BlueScript Drosophila melanogaster cDNA clone Drosophila melanogaster 38,28198-11-28

GM 083925 prime. The mRNA sequence. rxa 032121452 GB _ BA 1: CGBETPGE 2339X 93514 Corynebacterium glutamicum beta gene. Corynebacterium glutamicum 99,93197-09-08

Table 4 (continuation)

GB _ BA 1: SC5F2A 40105 AL049587 Streptomyces coelicolor cosmid 5F 2A. Streptomyces coelicolor A3(2) 57,5571999-05-24

GB _ BA 2: AF 008220220060 AF008220 Bacillus subtilis rmB-dnaB genomic region. Bacillus subtilis 40,00098-02-04 cxa 03220725 GB _ PL 1: CKHUP 22353X 66855 c. keslei HUP2 mRNA. Chlorella kessleri 45.32897-02-17

GB _ EST 38: AW 048153383 AW04815 UI-M-BH1-alq-h-05-0-UI sl NIH _ BMAP _ M _ S2 Mucuna mus minor cDNA clone Mucuna minor 41,75899-09-18

3 UI-M-BHl-alq-h-05-0-UI 3', mRNA sequence.

GB _ PL 1: CKHUP 22353X 66855 c. Chlorella kessleri 38,10697-02-17 example part example 1: preparation of Total genomic DNA of Corynebacterium glutamicum ATCC13032

A culture of Corynebacterium glutamicum (ATCC 13032) was grown overnight at 30 ℃ with vigorous shaking in BHI medium (Difco). The cells were collected by centrifugation, the supernatant was discarded and the cells were resuspended in 5ml of buffer I (5% of the original volume of the culture- -all indicated volumes have been calculated from 100ml of culture volume). Composition of buffer I: 140.34g/l sucrose, 2.46g/l sucrose 、10ml/l Solutions (100g/l, using Adjusted to pH6.7), 50ml/l M12 concentrate (10 g/l) 、1g/l 、2g/l 、0.2g/l 0.5g/l yeast extract (Difco),10ml/l microelement mixture (200 mg/l) 、10mg/l 、3mg/l 、30mg/l 、20mg/l 、1mg/l 、3mg/l 500mg/l complexing agent (EDTA or citric acid), 100ml/l vitamin mixture (0.2mg/l biotin, 0.2mg/l folic acid, 20mg/l p-aminobenzoic acid, 20mg/l riboflavin, 40mg/l calcium pantothenate (ca-panthothenate), 140mg/l nicotinic acid, 40mg/l pyridoxine hydrochloride, 200mg/l inositol). Lysozyme was added to the suspension to a final concentration of 2.5 mg/ml. After incubation at 37 ℃ for about 4 hours, the cell walls were degraded and the resulting protoplasts were harvested by centrifugation. The pellet was washed 1 time with 5ml of buffer I and 5ml of TE buffer (10 mM) lmMEDTA, pH8) 1 wash. The pellet was resuspended in 4ml of TE buffer, and 0.5ml of SDS solution (10%) and 0.5ml were added Solution (5M). After addition of proteinase K to a final concentration of 200. mu.g/ml, the suspension was incubated at 37 ℃ for about 18 hours. The DNA was purified by extraction with phenol, phenol-chloroform-isoamyl alcohol and chloroform-isoamyl alcohol using standard methods. The DNA was then precipitated by adding 1/50 volumes of 3M sodium acetate and 2 volumes of ethanol, followed by incubation at-20 ℃ for 30 minutes and centrifugation at 12,000rpm for 30 minutes in a high speed centrifuge using an SS34 rotor (Sorvall). The DNA was dissolved in 1ml of TE buffer containing 20. mu.g/ml RNase A and dialyzed against 1000ml of TE buffer at 4℃ for at least 3 hours. During this period, the buffer was changed 3 times. To a 0.4ml aliquot of the dialyzed DNA solution, 0.4ml of 2M was added And 0.8ml ethanol. After incubation at-20 ℃ for 30 min, by centrifugation (13,000rpm, Biofuge)Fresco, Heraeus, Hanau, germany) to collect DNA. The DNA pellet was dissolved in TE buffer. The DNA prepared by this method can be used for all purposes, including southern blotting or construction of genomic libraries. Example 2: construction of genomic library of Corynebacterium glutamicum ATCC13032 in Escherichia coli

Cosmid and plasmid libraries are constructed using the DNA prepared as described in example 1 according to well-known methods (see, for example, Sambrook, J. et al, (1989) "Molecular Cloning: A Laboratory Manual", Cold spring Harbor Laboratory Press, or Ausubel, F.M. et al (1994) "Current protocols in Molecular Biology", John Wiley&Sons.).

Any plasmid or cosmid may be used. Plasmids used in particular are the plasmids pBR322(Sutcliffe, J.G. (1979) Proc. Natl. Acad. Sci. USA, 75: 3737-. A gene library, in particular for C.glutamicum, can be constructed using the plasmid pSLl09 (Lee, H. -S., and A.J.Sinskey (1994) J.Microbiol.Biotechnol.4: 256-263). Example 3: DNA sequencing and computational function analysis

DNA sequencing was carried out using the genomic library described in example 2 according to standard methods, in particular the chain termination method using an ABI377 sequencer (see e.g.Fleischman, R.D. et al (1995) "random whole genome sequencing and Assembly of Haemophilus influenzae Rd.", Science 269: 496-512). Sequencing primers having the following nucleotide sequences were used: 5'-GGAAACAGTATGACCATG-3' or 5'-GTAAAACGACGGCCAGT-3'. Example 4: in vivo mutagenesis

Plasmid (or other vector)DNA can be mutagenized in vivo by passaging E.coli or other microorganisms (e.g., Bacillus or yeast such as Saccharomyces cerevisiae) with an impaired ability to maintain the integrity of its genetic information. The DNA repair system genes of typical mutator strains are mutated (e.g., mutHLS, mutD, mutT, etc.; reference Rupp, W.D (1996) DNA repair mechanisms, described in Escherichia coli and Salmonella, p. 2277-2294, ASM: Washington.). Such strains are well known to those skilled in the art. For example Greener, a. and Callahan, m. (1994) Strategies 7: the use of said strains is described in 32-34. Example 5: DNA transfer between E.coli and C.glutamicum

Several species of Corynebacterium and Brevibacterium contain endogenous plasmids (e.g., pHM1519 or pBL1) that replicate autonomously (for review see, e.g., Martin, J.F. et al (1987) Biotechnology, 5: 137-146). Coli and Corynebacterium glutamicum shuttle vectors can be readily constructed using E.coli standard vectors (Sambrook, J. et al (1989), "Molecular Cloning: organism Manual", Cold Spring Harbor Laboratory Press or Autosubel, F.M. et al (1994) "Current Protocols in Molecular Biology", John Wiley&Sons) to which the origin of replication and a suitable marker for Corynebacterium glutamicum have been added. The origin of replication is preferably taken from an endogenous plasmid isolated from Corynebacterium and Brevibacterium species. Transformation markers for these species specifically used are kanamycin resistance Genes (e.g., those produced by the Tn5 or Tn903 transposons) or chloramphenicol resistance Genes (Winnacker, E.L, (1987), From Genes to Clones-Introduction to Gene Technology, VCH, Weinheim). A number of examples are given in the literature for the construction of various shuttle vectors which are replicable in E.coli and C.glutamicum and which can be used for several purposes, including Gene overexpression (cf. for example Yoshihama, M. et al (1985) J.Bacteriol.162: 591-597, Martin J.F. et al (1987) Biotechnology, 5: 137-146 and Eikmanns, B.J. et al (1991) Gene, 102: 93-98).

The gene of interest can be cloned into one of the above shuttle vectors and the hybrid vector introduced into the C.glutamicum strain using standard methods. Corynebacterium glutamicum may be transformed by the following method: protoplast transformation (Kastsumata, R.et al (1984) J.Bacteriol.159306-311), electroporation (Liebl, E.et al (1989) FEMS Microbiol.letters, 53: 399-. The shuttle vector may also be transferred from C.glutamicum to E.coli by preparing plasmid DNA from C.glutamicum (using standard methods well known in the art) and transforming it into E.coli. This transformation step can be carried out by standard methods, but preferably Mcr-deficient E.coli strains such as NM522(Gough and Murray (1983) J.mol.biol.166: 1-19) are used.

Plasmids comprising pCG1 (U.S. Pat. No. 4,617,267) or fragments thereof and optionally the TN903 kanamycin resistance gene (Grindley, N.D. and Joyce, C.M, (1980) Proc. Natl. Acad. Sci. USA 77 (12): 7176-. In addition, plasmid pSL109 can also be used to overexpress various genes in Corynebacterium glutamicum strains (Lee, H. -S., and A.J.Sinskey (1994) J.Microbiol.Biotechnol.4: 256-263).

In addition to the use of replicating plasmids, gene overexpression can also be achieved by integration into the genome. Genomic integration in Corynebacterium glutamicum or other Corynebacterium or Brevibacterium species can be achieved by known methods, for example by homologous recombination with genomic regions, restriction endonuclease-mediated integration (REMI) (see, for example, DE 19823834) or by using transposons. The activity of the gene of interest may also be modulated by modifying the regulatory regions (e.g., promoter, repressor, and/or enhancer) as follows: sequence modifications, insertions or deletions are made using site-directed methods (e.g., homologous recombination) or random event-based methods (e.g., transposon mutagenesis or REMI). A nucleic acid sequence acting as a transcription terminator may also be inserted 3' to the coding region of one or more of the genes of the present invention; such terminators are well known in the art, for example, in Winnacker, E.L, (1987) Fromgenes to Clones-Introduction to Gene technology, VCH: weinheim) is described. Example 6: evaluation of expression of mutant proteins

The observation of mutein activity in transformed host cells relies on the fact that: the mutant protein is expressed in a similar manner and in a similar amount as the wild-type protein. A useful method for determining the level of transcription of a mutant gene (an indicator of the amount of mRNA that is effective to translate the gene product) is by northern blotting (see, e.g., Ausubel et al (1988) Current Protocols in molecular Biology, Wiley: New York) in which a primer designed to bind the gene of interest is labeled with a detectable label (usually radioactive or chemiluminescent) such that, when total RNA is extracted from the biological culture, electrophoresed on a gel, transferred to a stable substrate, and incubated with the probe, the binding and amount of the probe indicates the presence of the gene and indicates the amount of mRNA for the gene. Such information is evidence of the extent of transcription of the mutated gene. Total cellular RNA can be prepared from C.glutamicum using several methods well known in the art, such as Bormann, E.R. et al (1992) mol. Microbiol.6: 317 and 326.

To assess the presence or relative amount of the mRNA translational protein, standard techniques such as Western blotting can be used (see, e.g., Ausubel et al (1988) Current Protocols in molecular Biology, Wiley: New York). In this process, total cellular proteins are extracted, separated by gel electrophoresis, transferred to a matrix such as nitrocellulose and incubated with a probe such as an antibody that specifically binds the desired protein. Such probes are typically labeled with readily detectable chemiluminescent or colorimetric labels. The presence and amount of the marker observed indicates the presence and amount of the desired mutein in the cell. Example 7: culture medium and culture conditions for genetically modified corynebacterium glutamicum

Genetically modified coryneform bacteria are cultured in synthetic or natural growth media. Many different growth media for coryneform bacteria are well known and readily available (Lieb et al (1989) appl. Microbiol. Biotechnol., 32: 205-210; von der Osten et al (1998) Biotechnol Letters, 11: 11-16; patent DE 4,120,867; Liebl (1992) "Corynebacterium", written in: The Procaryotes, Vol.II, Balows, A. et al., Springer-Verlag). The composition of these media was: one or more carbon sources, nitrogen sources, inorganic salts, vitamins and trace elements. Preferably the carbon source is a sugar such as a monosaccharide, disaccharide or polysaccharide. Glucose, fructose, mannose, galactose, ribose, sorbose, ribulose, lactose, maltose, sucrose, raffinose, starch or cellulose are very good carbon sources, for example. The medium may also be provided with sugars by complex compounds such as molasses or other by-products of refined sugar. It may also be beneficial to provide a mixture of different carbon sources. Other possible carbon sources are alcohols and organic acids, such as methanol, ethanol, acetic acid or lactic acid. The nitrogen source is usually an organic or inorganic nitrogen compound, or a substance containing such a compound. Typical nitrogen sources include ammonia gas or ammonium salts, such as ammonium chloride or sulfate, ammonium hydroxide, nitrates, urea, amino acids, or complex nitrogen sources such as corn steep liquor, soybean meal, soybean protein, yeast extract, meat extract, and the like.

The medium may contain inorganic saltcompounds including hydrochlorides, phosphites or sulfates of calcium, magnesium, sodium, cobalt, molybdenum, potassium, manganese, zinc, copper and iron. Chelating compounds may be added to the medium to maintain the metal ions in solution. Particularly effective chelating compounds include dihydric phenols (e.g., catechol or protocatechuic acid) or organic acids (e.g., citric acid). The medium also conventionally contains other growth factors, such as vitamins or growth promoters, examples of which include biotin, riboflavin, thiamine, folic acid, nicotinic acid, pantothenate and pyridoxine. Growth factors and salts are typically derived from complex media components such as yeast extract, molasses, corn steep liquor, and the like. The exact composition of the media compounds is closely related to the direct experiment and depends on each particular case. Information on medium optimization is available in the textbook "Applied microbiol. physiology, a practical approach (p.m. rhodes, p.f. stanbury, IRL Press (1997), p.53-73, ISBN 0199635773). Growth media may also be selected from commercial suppliers, such as Standard No. 1 (Merck) or BHI (grain heart infusion, DIFCO), and the like.

All media components were sterilized by heat sterilization (20 min at 1.5 Pa and 121 ℃) or by filtration. The components may be sterilized together, or separately if desired. All media components may be present at the beginning of the cultivation or may optionally be added continuously or batchwise.

Culture conditions were specified for each experiment. The temperature should be 15-45 ℃. The culture temperature can be kept constant or varied experimentally. The pH of the medium should be 5-8.5, preferably about 7.0, and a buffer may be added to the medium to maintain the pH. A typical buffer for this purpose is potassium phosphate buffer. Synthetic buffers such as MOPS, HEPES, ACES and the like may be used alternatively or concurrently. Sodium hydroxide or ammonium hydroxide may also be added during the cultivation to maintain a constant cultivation pH. If complex media components such as yeast extract are used, the additional buffering agent requirements may be reduced because many complex compounds have high buffering capacity in practice. If a fermenter is used to culture the microorganism, ammonia gas may also be used to control the pH.

The incubation time is usually several hours to several days. The incubation time is selected to maximize the amount of product accumulated in the liquid medium. The disclosed growth experiments can be performed in a variety of vessels, such as microtiter plates, glass test tubes, glass flasks or glass or metal fermentors of different sizes. For screening of large numbers of clones, micro-titer plates, glass test tubes or shake flasks (with or without baffles) should be used for culturing the microorganisms. Preferably, a 100ml shake flask is used, which contains 10% by volume of the desired growth medium. The culture flask should be shaken on a rotary shaker (amplitude 25mm) using a speed range of 100-300 rpm. Maintaining a humid atmosphere minimizes evaporative loss; or a mathematical correction for evaporation loss should be made.

If genetically modified clones are tested, unmodified control clones or control clones containing the base plasmid without any insert should also be tested. Cells grown on agar plates such as CM plates (10g/l glucose, 2.5g/l sodium chloride, 2g/l urea, 10g/l polypeptone, 5g/l yeast extract, 5g/l meat extract, 22g/l agar, pH6.8, 2M sodium hydroxide) that have been incubated at 30 ℃ are used to inoculate the medium to OD₆₀₀Is 0.5-1.5. The inoculation of the medium is accomplished by adding an aqueous saline suspension of cells of Corynebacterium glutamicum obtained from CM plates or by adding a liquid preculture of this bacterium. Example 8: in vitro analysis of function of muteins

The general overview of Enzymes and The details concerning Structure, kinetics, principles, Methods, applications and many examples of Enzyme activity assays can be found, for example, in Dixon, M.and Webb, E.C. (1979) Enzymes, Longmans: London; Fersht, (1985) Enzyme Structure and Mechanism, Freeman: New York; Walsh, (1979) Enzyme Reaction mechanics: Freeman: Sanfrancisco; Price, N.C., Steven, L. (1982) standards of Enzymes, Oxford Univ.Press: Oxford; Angle R, P.D.Bowy, 1983, pH, 1982) Enzymes of enzymology, Oxford Univ.Press, Press, pH, 1983, pH, 1982, publication No. E.A, pH, 19832, publication No. E.A. (19832), and book of Enzymes, pH 52, publication No. 11, publication No. E.C., Enzyme, engineering, pH, 1982, publication No. 11, publication No. 2, publication No. E.E.E.E.E.E.E.E.E.E.E.E.E.E.E.E.E.E.C., pH, E.E.C., engineering, published, U.S. 3, 1982, publication No. 2, publication No. 3, publication No. 2, publication No. 2, publication No. 2, publication No. publication No.

Reporter assays (e.g., Kolmar, H. et al (1995) EMBO J.14: 3895-3904 and the assays described in the references cited therein) can be used to measure the effect of the protein on the expression of other molecules.

Membrane pores, channels and transporters "according to, for example, Gennis, R.B (1989), are carried by: biomembrans, Molecular Structure and Function, Springer: the activity of membrane transporters can be determined by the technique described in Heidelberg, pages 85-137, 199-234 and 270-322. Example 9: analysis of the effects of the mutant proteins on the production of the desired product

The effect of genetic improvement in C.glutamicum on the production of a desired compound (e.g.an amino acid) can be assessed as follows: the modified microorganism is grown under suitable conditions, such as those described above, and the medium and/or cell components are then analyzed for increased production of the desired product (i.e., amino acid). Such analytical techniques are well known to those of ordinary skill in the art and include spectroscopic methods, thin layer chromatography, various staining methods, enzymatic and microbiological methods, and analytical chromatographic methods such as high performance liquid chromatography (see, for example, Ullman, Encyclopedia of Industrial chemistry, Vol. A2, pp. 89-90 and 443, VCH: Weinheim (1985); Fallon, A. et al, (1987) "use of HPLC in Biochemistry", Vol. laboratory technologies in Biochemistry and Molecular Biology, Vol. 17; Rehm et al (1993) Biotechnology, Vol. 3, Chapter. III: "Recovery and purification of products", Vol. 469-P. 714, VCH: Weinheim; Belter, P.A. et al (1988) Biochemistry: horizontal chemistry, Johnology, Wilford. J. 1988; Johnology, and Biochemical engineering J. purification, Vol. J.D; Wilford. J. and Biochemical purification, Vol. Biotechnology, Vol. 1988; John. Biochemical engineering, Inc. J.D; Wilford. J. Biotechnology, Inc. 358, Inc. Biochemical engineering, Inc. Biotechnology, Inc. A. and Biochemical engineering, Inc. 2. 1988, Inc. 2. Biochemical engineering, volume B3, chapter 11, pages 1-27, VCH: weinheim; and Dechow, F.J (1989) Separation and purification technologies in biotechnology, Noyes Publications).

In addition to detecting the end product of the fermentation, other components of metabolic pathways that utilize the desired product, such as intermediates and by-products, can also be analyzed to determine the overall efficiency of producing the compound. Analytical methods include measuring nutrient levels (e.g., sugars, hydrocarbons, nitrogen sources, phosphates and other ions) in the culture medium, measuring biomass composition and growth, analyzing the yield of common metabolites of biosynthetic pathways, and gases produced during fermentation. Standard methods for these assays are outlined in Applied microbiological biology, A Practical Approach, P.M.Rhodes and P.F.Stanbury, IRL Press, pages 103-129, 131-163 and 165-192 (ISBN: 0199635773) and references cited therein. Example 10: purification of the desired product from Corynebacterium glutamicum cultures

The desired product can be recovered from the cells or supernatant of Corynebacterium glutamicum of the above cultures by various methods known in the art. If the desired product is not secreted from the cells, the cells can be harvested from the culture by low speed centrifugation and lysed using standard techniques, such as mechanical force or sonication. Cell debris was removed by centrifugation and the supernatant fraction containing the soluble protein was retained for further purification of the desired compound. If the product is secreted from the C.glutamicum cells, the cells are removed from the culture by low-speed centrifugation, and the supernatant fraction is retained for further purification.

The supernatant fraction from either purification process is subjected to chromatography on a suitable resin, wherein the desired molecule remains on the chromatography resin and most of the impurities in the sample are washed out, or the impurities remain on the resin and the sample is washed out. The chromatography steps may be repeated as desired, using the same or different chromatography resins. The person skilled in the art is well versed in the selection of suitable chromatography resins and the most efficient use of the particular molecule to be purified. The purified product can be concentrated by filtration or ultrafiltration and stored at the temperature at which the product is most stable.

There are many purification methods known in the art, and the above purification methods are merely illustrative of the present invention. Such purification techniques are described, for example, in Bailey, j.e.&Ollis, d.f., biochemical engineering Fundamentals, McGraw-Hill: new york (1986).

The identity and purity of the isolated compound can be assessed using standard techniques in the art. The standard techniques include High Performance Liquid Chromatography (HPLC), spectroscopy, staining, thin layer chromatography, NIRS, enzymatic assays, or microbiological assays. A review of the assay methods is given in: patek et al (1994) appl.environ.microbiol.60: 133-140; malakhova et al (1996) Biotek technology iya 11: 27-32; and Schmidt et al (1998) bioprocess Engineer, 19: 67 to 70; ulmann's Encyclopedia of Industrial Chemistry, (1996) Vol.A 27, VCH: weinheim, pages 89-90, 521-540, 540-547, 559-566, 575-581 and 581-587; michal, G. (1999) Biochemical Pathways: an Atlas of Biochemistry and Molecular Biology, John Wiley and Sons; the use of Fallon, A. et al (1987) HPLC in biochemistry is described in: laboratory techniques in Biochemistry and Molecular Biology, Vol.17. Example 11: analysis of the Gene sequence of the present invention

Comparison of sequences and determination of the percentage homology of the two sequences is a technique known in the art and can be carried out using mathematical algorithms, such as the algorithm of Karlin and Altschul ((1990) proc. natl. acad. sci. usa 87: 2264-68) and its modified algorithm (Karlin and Altschul (1993) proc. nat. acad. sci. usa 90: 5873-77. this algorithm incorporates the NBLAST and XBLAST programs of Altschul et al (1990) j. mol. biol. 215: 403-10 (version 2.0.) the use of the NBLAST program, the score BLAST nucleotide search being carried out at 100, the byte length 12, in order to obtain a nucleotide sequence homologous to the MCT Nucleic acid molecule of the invention. the use of the XBLAST program, the score BLAST being 50, the byte length 3, in order to obtain a nucleotide sequence homologous to the MCT protein molecule of the invention, (for comparison purposes) the use of the BLAST program, the gape 2. gape, the BLAST programs are used when the sequence is introduced according to the goal. One skilled in the art would know how to optimize the parameters of the programs (e.g., XBLAST and NBLAST) used to analyze a given sequence.

Another example of a mathematical algorithm for sequence comparison is the Meyers and Miller algorithms ((1988) Compout. Appl. biosci.4: 11-17). This algorithm incorporates the ALIGN program (version 2.0), which is an integral part of the GCG sequence alignment software package. When comparing amino acid sequences using the ALIGN program, a PAM120 weighted residue table, a gap length penalty of 12, and a gap penalty of 4 can be used. Other sequence analysis algorithms are known in the art, including Torelli and Robotti (1994) Compout.Appl.biosci.10: 3-5 introduction of ADVANCE and ADAM; and Pearson and Lipman (1988) p.n.a.s.85: 2444-8 introduction to FASTA.

Percent homology of two amino acid sequences can also be obtained using the GAP program in the GCG package (available at http:// www.gcg.com) using Blousm 62 or PAM250 matrices and GAP weights of 12, l0, 8, 6 or 4 and length weights of 2, 3 or 4. The percent homology of two nucleic acid sequences can be obtained using the GAP program in the GCG package using standard parameters, such as a GAP weight of 50 and a length weight of 3.

Comparative Analysis of the gene sequences of the invention with those in Genbank can be performed using techniques known in the art (see, e.g., Bexevanis and Ouelette's eds (1998) Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins, John Wiley and Sons: New York). The gene sequences of the present invention were compared with the genes in Genbank in a 3-step method. In the first step, BLASTN analysis (e.g., local alignment analysis) of each sequence of the present invention with Genbank nucleotide sequences is performed, and the first 500 hits are retained for further analysis. Next, a FASTA search (e.g., a joint local and global sequence alignment analysis, in which defined regions of the sequences are aligned) is performed on the 500 hits. Finally, global sequence alignments were performed on each gene sequence of the invention with each of the first 3 FASTA hits using the GAP program in the GCG software package (using standard parameters). To obtain correct results, the length of the sequence taken from Genbank is adjusted to the length of the query sequence using methods well known in the art. The analytical results are shown in Table 4. The data obtained are identical to those obtained by GAP (global) analysis of the genes of the invention and of the reference sequences of Genbank alone, but require a significant reduction in calculation time compared to such database-wide GAP (global) analysis. Sequences of the invention that did not achieve a sequence alignment above the threshold are indicated in table 4as having no sequence alignment information. Those skilled in the art will further appreciate that the percent homology for GAP sequence alignment under the table 4 heading "homology (%) (GAP)" is listed in european numeric format, where "stands for decimal point. For example, the value "40,345" in this column means "40.345%". Example 12: construction and manipulation of DNA microarrays

Furthermore, the sequences of the present invention may be used to construct and use DNA microarrays (the design, methodology and use of DNA arrays are well known in the art, e.g., as described in Schena, M et al (1995) Science 270: 467-470; Wodicka, L. et al (1997) Nature Biotechnology 15: 1359-1367; DeSaizieu, A. et al (1998) Nature Biotechnology 16: 45-48; and DeRisi, J.L. et al (1997) Science 278: 680-686).

DNA microarrays are solid or flexible supports, such as materials composed of nitrocellulose, nylon, glass, silicone, or other substances. The nucleic acid molecules are bound to the surface of the support in an ordered manner. After suitable labeling, other nucleic acids or mixtures of nucleic acids can be hybridized to the immobilized nucleic acid molecules, and labels can be used to monitor and measure the respective signal intensities of the hybridized molecules in a defined region. The method can simultaneously quantify the relative or absolute amount of all or selected nucleic acids in an administered nucleic acid sample or mixture. Thus, DNA microarrays can analyze expression of a variety (up to 6800 or more) of nucleic acids in parallel (see, e.g., Schena, M. (1996) BioEssays 18 (5): 427-.

The sequences of the invention can be used to design oligonucleotide primers that are capable of amplifying defined regions of one or more Corynebacterium glutamicum genes by a nucleic acid amplification reaction, such as the polymerase chain reaction. The 5 'or 3' oligonucleotide primers or suitable linkers are selected and designed such that the resulting PCR products are covalently linked to the surface of the support medium as described above (see also e.g.Schena, M. et al (1995) Science 270: 467-470).

According to Wodicka, L.et al (1997) Nature Biotechnology 15: 1359-1367 nucleic acid microarrays can also be constructed by in situ oligonucleotide synthesis. Photolithography is used to expose precisely defined areas of the substrate. Thus activating the photolabile protecting group to add the nucleotide, while the light-shielding region is not changed at all. Subsequent cycles of protection and photoactivation allow the synthesis of different oligonucleotides at defined positions. By solid phase synthesis of oligonucleotides, defined regions of the genes of the invention can be synthesized on a microarray.

Nucleic acid molecules of the invention present in a sample or a mixture of nucleotides can hybridize to the microarray. These nucleic acid molecules can be labeled according to standard methods. Briefly, nucleic acid molecules (e.g., mRNA molecules or DNA molecules) are labeled, for example, by incorporation of isotopes or fluorescently labeled nucleotides during reverse transcription or DNA synthesis. Hybridization of labeled nucleic acids to microarrays has been described (e.g., as described in Schena, M et al (1995) supra; Wodicka, L et al (1997), supra; and DeSaizieu A. et al (1998), supra). Detection and quantification of the hybrid molecule must be adapted to the particular incorporated label. For example, radioactive labels can be detected as described in Schena, M et al (1995) (supra), while fluorescent labels can be detected, for example, as described in Shalon et al (1996) Genome Research 6: 639-.

The use of the sequences of the invention in the above-described DNA microarray technology allows a comparable analysis of different strains of Corynebacterium glutamicum or other species of Corynebacterium. Nucleic acid array methodologies facilitate, for example, the study of inter-strain variation based on individual transcript profiles and the identification of important genes for specific and/or desired strain characteristics such as pathogenicity, productivity, and stress tolerance. Furthermore, the expression profiles of the genes of the present invention during the fermentation reaction can be compared using nucleic acid array technology. Example 13: analysis of cell proteome dynamics (Proteomics)

The genes, compositions and methods of the invention are useful for studying protein group interactions and kinetics, referred to as "proteomics". Protein groups of interest include, but are not limited to, the total protein group of corynebacterium glutamicum (e.g., as compared to protein groups of other organisms), proteins that are active under specific environmental or metabolic conditions (e.g., high or low temperature during fermentation, or high or low pH), proteins that are active during specific periods of growth and development.

The protein population can be analyzed by various techniques known in the art, such as gel electrophoresis. Cellular proteins can be obtained, for example, by lysis or extraction, and can be separated from one another using various electrophoretic techniques. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) separates proteins based primarily on their molecular weight. Isoelectric focusing polyacrylamide gel electrophoresis (IEF-PAGE) separates proteins by their isoelectric point (which reflects not only the amino acid sequence but also post-translational modifications of the protein). Another more preferred method of protein analysis is sequential combined IEF-PAGE and SDS-PAGE, referred to as 2-D-gel Electrophoresis (see, e.g., Hermann et al (1998) Electrophoresis 19: 3217-3221; Foutoulakis et al (1998) Electrophoresis 19: 1193-1202; Langen et al (1997) Electrophoresis 18: 1184-1192; Antelmann et al (1997) Electrophoresis 18: 1451-1463). Other protein separation techniques may also be used for protein separation, such as capillary gel electrophoresis; such techniques are well known in the art.

Proteins separated by the method can be visualized using standard techniques such as staining or labeling. Suitable staining methods are known in the art and include Coomassie Brilliant blue, silver staining or fluorescent dyes such as Sypro Ruby (Molecular Probes). Containing radiolabeled amino acids or other protein precursors in C.glutamicum medium (e.g.³⁵S-methionine,³⁵S-cysteine,¹⁴C-labeled amino acid,¹⁵N-amino acid, Or Or¹³C-tag amino acids) can label these cellular proteins prior to their isolation. Fluorescent labels may also be used. The marker proteins can be extracted, separated and isolated according to the techniques described previously.

Proteins visualized by the technique can be further analyzed by measuring the amount of dye or label used. The amount of a given protein can be quantified, for example, optically, and compared to the amount of other proteins on the same gel or on other gels. Protein comparisons on gels can be performed, for example, using optical comparison, spectroscopy, image scanning and gel analysis, or by using photographic film and screening. Such techniques are well known in the art.

To determine the identity of any given protein, direct sequencing or other standard techniques may be employed. For example, N-and/or C-terminal amino acid sequencing (e.g., Edman degradation) can be used, as can mass spectrometry (in particular MALDI or ESI techniques (see, e.g., Langen et al (1997) Electrophoresis 18: 1184-1192)). The protein sequences provided herein can be used to identify corynebacterium glutamicum proteins by the described techniques.

The information obtained by the method can be used to compare the pattern of protein presence, activity or modification between different samples of various biological conditions (e.g., different organisms, fermentation time points, medium conditions or different biotopes, etc.). The data obtained from these experiments alone or in combination with other techniques may be used for various purposes, for example to compare various biological behaviors of a given (e.g.metabolic) situation, to increase the productivity of a fine chemical-producing strain or to increase the yield of a fine chemical. Equivalent embodiments

Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. The following claims include such equivalent embodiments.

Sequence listing<110>BASF corporation (BASF Aktiengesellschaft)<120>Corynebacterium glutamicum gene<130>BGI-125CPPC<140>PCT/IB00/00926<141>2000-06-23<160>676<210>1<211>578<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (555)<223>RXN03097<400>1att tca gcc agt gca ggt gct ata ggt tgg tta att tta gaa tat att 3948 151015 ttt aaa aag acg aca agt tta ctt gga ctt tta ctc ggt gca tta gca Phe Lys Lys Thr Thr Ser Leu Leu Gly Leu Leu Leu Gly Ala Leu Ala, which encodes proteins involved in membrane synthesis and membrane transport.

20 25 30gga tta gtt gtt att act cct gca gca gga tat gta aca tat ctt agt 144Gly Leu Val Val Ile Thr Pro Ala Ala Gly Tyr Val Thr Tyr Leu Ser

35 40 45gca aca ata atg gct tta ata gga ggt atc tgt tgt tat att gtc att 192Ala Thr Ile Met Ala Leu Ile Gly Gly Ile Cys Cys Tyr Ile Val Ile

50 55 60aat tac atc aag gta aaa cta aaa tat cat gat gca tta gat gca ttt 240Asn Tyr Ile Lys Val Lys Leu Lys Tyr His Asp Ala Leu Asp Ala Phe 65 70 75 80ggt att cat ggt gtt ggt ggt att att ggt gct gtt tta aca gca gtt 288Gly Ile His Gly Val Gly Gly Ile Ile Gly Ala Val Leu Thr Ala Val

85 90 95ttc caa agt aaa aaa gcc aat cct gac att gag aat ggc ttt att tat 336Phe Gln Ser Lys Lys Ala Asn Pro Asp Ile Glu Asn Gly Phe Ile Tyr

100 105 110act ggt gac ata cat att ata ctt gta caa ata tta tgt gta aca gca 384Thr Gly Asp Ile His Ile Ile Leu Val Gln Ile Leu Cys Val Thr Ala

115 120 125gtt gta att ttt agt atc gtc atg acg ttt att att gcg aaa gta att 432Val Val Ile Phe Ser Ile Val Met Thr Phe Ile Ile Ala Lys Val Ile

130 135 140aaa tta att aca cca tta tct gtt acg gaa caa gaa acg aat ata gga 480Lys Leu Ile Thr Pro Leu Ser Val Thr Glu Gln Glu Thr Asn Ile Gly145 150 155 160tta gac aag att gtt cac ggt gaa cat gct tac ttt gaa ggt gag cta 528Leu Asp Lys Ile Val His Gly Glu His Ala Tyr Phe Glu Gly Glu Leu

165 170 175aat aga ttc aat aaa cat att cga tat tagaatatat ttacatagaa tat 578Asn Arg Phe Asn Lys His Ile Arg Tyr

180185<210>2<211>185<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>2Ile Ser Ala Ser Ala Gly Ala Ile Gly Trp Leu Ile Leu Glu Tyr Ile 151015 Phe Lys Lys Thr Thr Ser Leu Leu Gly Leu Leu Leu Gly Ala Leu Ala

20 25 30Gly Leu Val Val Ile Thr Pro Ala Ala Gly Tyr Val Thr Tyr Leu Ser

35 40 45Ala Thr Ile Met Ala Leu Ile Gly Gly Ile Cys Cys Tyr Ile Val Ile

50 55 60Asn Tyr Ile Lys Val Lys Leu Lys Tyr His Asp Ala Leu Asp Ala Phe 65 70 75 80Gly Ile His Gly Val Gly Gly Ile Ile Gly Ala Val Leu Thr Ala Val

85 90 95Phe Gln Ser Lys Lys Ala Asn Pro Asp Ile Glu Asn Gly Phe Ile Tyr

100 105 110Thr Gly Asp Ile His Ile Ile Leu Val Gln Ile Leu Cys Val Thr Ala

115 120 125Val Val Ile Phe Ser Ile Val Met Thr Phe Ile Ile Ala Lys Val Ile

130 135 140Lys Leu Ile Thr Pro Leu Ser Val Thr Glu Gln Glu Thr Asn Ile Gly145 150 155 160Leu Asp Lys Ile Val His Gly Glu His Ala Tyr Phe Glu Gly Glu Leu

165 170 175Asn Arg Phe Asn Lys His Ile Arg Tyr

180185<210>3<211>373<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (373)<223>RXA02099<400>3tagttagagc tggttcaagg ggtgtcaatc ccaaaaggca ctccttgaac tcatgaaaaa 60gcttgacaaa acttcaacgt caaaggaggt catccacgct atg ggt gca gat caa 115

Met Gly Ala Asp Gln

1 5att gca gca gtc tcc ggc aat tca gct tgg atg ctg atg tcc gcg tcg 163Ile Ala Ala Val Ser Gly Asn Ser Ala Trp Met Leu Met Ser Ala Ser

10 15 20ctc gtg ctg cta atg aca cca gca ctg gca ctt ttc tat ggc ggc atg 211Leu Val Leu Leu Met Thr Pro Ala Leu Ala Leu Phe Tyr Gly Gly Met

25 30 35tct cgt caa aag tcc gtg ctc aac atg atg atg atg tcc ttt gga gca 259Ser Arg Gln Lys Ser Val Leu Asn Met Met Met Met Ser Phe Gly Ala

40 45 50ttg ggc gtc gtt act gtt att tac ctc ttg tgg gga tgg tcg atg tct 307Leu Gly Val Val Thr Val Ile Tyr Leu Leu Trp Gly Trp Ser Met Ser

55 60 65tat gga acc caa tca atc gcg gga atc ttt gct aac cct ttt gag ttc 355Tyr Gly Thr Gln Ser Ile Ala Gly Ile Phe Ala Asn Pro Phe Glu Phe 70 7580 85ttc ggt ctt aaa gat tcc 373Phe Gly Leu Lys Asp Ser

90<210>4<211>91<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>4Met Gly Ala Asp Gln Ile Ala Ala Val Ser Gly Asn Ser Ala Trp Met 151015 Leu Met Ser Ala Ser Leu Val Leu Leu Met Thr Pro Ala Leu Ala Leu

20 25 30Phe Tyr Gly Gly Met Ser Arg Gln Lys Ser Val Leu Asn Met Met Met

35 40 45Met Ser Phe Gly Ala Leu Gly Val Val Thr Val Ile Tyr Leu Leu Trp

50 55 60Gly Trp Ser Met Ser Tyr Gly Thr Gln Ser Ile Ala Gly Ile Phe Ala 65 70 75 80Asn Pro Phe Glu Phe Phe Gly Leu Lys Asp Ser

8590<210>5<211>879<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (856)<223>RXA00104<400>5tgcaaagaca tcccggaacc actccgctac ttgaggtcgg aatcgggaaa gaatgctttt 60agccatgcct taatgtaacc aaacatctag aattgagaac atg act gct cag att 115

Met Thr Ala Gln Ile

1 5gat gat tcg atc ctc acc cat cgt ctc gcc caa ggc acc gga gaa atc 163Asp Asp Ser Ile Leu Thr His Arg Leu Ala Gln Gly Thr Gly Glu Ile

10 15 20ctc aaa ggt gtc cgc aat gtt ggg gtg tta aga ggt cgg aat ctc ggt 211Leu Lys Gly Val Arg Asn Val Gly Val Leu Arg Gly Arg Asn Leu Gly

25 30 35gat gcc ggc gac gaa ctc gca caa agt tgg att gct cga gtg ttg gag 259Asp Ala Gly Asp Glu Leu Ala Gln Ser Trp Ile Ala Arg Val Leu Glu

40 45 50cag cac cgc ccc aac gat gga ttc ctg tct gaa gaa gcc gcc gac aac 307Gln His Arg Pro Asn Asp Gly Phe Leu Ser Glu Glu Ala Ala Asp Asn

55 60 65cca gac cgc cta tcc aag gac cgc gtg tgg atc atc gat ccc ctc gac 355Pro Asp Arg Leu Ser Lys Asp Arg Val Trp Ile Ile Asp Pro Leu Asp 70 75 80 85ggc acc aaa gaa ttc gcc acc ggc cgc cag gac tgg gca gta cac atc 403Gly Thr Lys Glu Phe Ala Thr Gly Arg Gln Asp Trp Ala Val His Ile

90 95 100gca ctg gta gaa aac ggt gtt ccc acc cac gcc gct gtt ggc ctc ccc 451Ala Leu Val Glu Asn Gly Val Pro Thr His Ala Ala Val Gly Leu Pro

105 110 115gac ctt ggc gtg gtg ttc cac tcc gct gat gcc cgc gcc gtg act ggc 499Asp Leu Gly Val Val Phe His Ser Ala Asp Ala Arg Ala Val Thr Gly

120 125 130cct tac tcc aag gtc atc gcc atc tcc cac aac cgc cca cca aag gtt 547Pro Tyr Ser Lys Val Ile Ala Ile Ser His Asn Arg Pro Pro Lys Va1

135 140 145gct cta tct tgc gca gag cag ctc ggc ttt gaa acc aag gcc ctt gga 595Ala Leu Ser Cys Ala Glu Gln Leu Gly Phe Glu Thr Lys Ala Leu Gly150 155 160 165tcc gca ggc gct aaa gca atg cac gtt ctc ctc ggt gac tac gac gcc 643Ser Ala Gly Ala Lys Ala Met His Val Leu Leu Gly Asp Tyr Asp Ala

170 175 180tac atc cac gcc ggc ggc caa tac gag tgg gat tcc gca gca cca gtc 691Tyr Ile His Ala Gly Gly Gln Tyr Glu Trp Asp Ser Ala Ala Pro Val

185 190195ggc gtc tgc aag gca gca ggc ttg cac tgc tcc agg ctc gac ggt tcc 739Gly Val Cys Lys Ala Ala Gly Leu His Cys Ser Arg Leu Asp Gly Ser

200 205 210gag ctg acc tac aac aac aaa gac acc tac atg cca gac atc ttg atc 787Glu Leu Thr Tyr Asn Asn Lys Asp Thr Tyr Met Pro Asp Ile Leu Ile

215 220 225tgt cgc cct gaa ctt gca gat gaa ctt ctc gag atg tgc gcg aag ttc 835Cys Arg Pro Glu Leu Ala Asp Glu Leu Leu Glu Met Cys Ala Lys Phe230 235 240 245tac gag gag aat gga act tac taacgctgtt atgatgacgg cat 879Tyr Glu Glu Asn Gly Thr Tyr

250<210>6<211>252<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>6Met Thr Ala Gln Ile Asp Asp Ser Ile Leu Thr His Arg Leu Ala Gln 151015 Gly Thr Gly Glu Ile Leu Lys Gly Val Arg Asn Val Gly Val Leu Arg

20 25 30Gly Arg Asn Leu Gly Asp Ala Gly Asp Glu Leu Ala Gln Ser Trp Ile

35 40 45Ala Arg Val Leu Glu Gln His Arg Pro Asn Asp Gly Phe Leu Ser Glu

50 55 60Glu Ala Ala Asp Asn Pro Asp Arg Leu Ser Lys Asp Arg Val Trp Ile 65 70 75 80Ile Asp Pro Leu Asp Gly Thr Lys Glu Phe Ala Thr Gly Arg Gln Asp

85 90 95Trp Ala Val His Ile Ala Leu Val Glu Asn Gly Val Pro Thr His Ala

100 105 110Ala Val Gly Leu Pro Asp Leu Gly Val Val Phe His Ser Ala Asp Ala

115 120 125Arg Ala Val Thr Gly Pro Tyr Ser Lys Val Ile Ala Ile Ser HisAsn

130 135 140Arg Pro Pro Lys Val Ala Leu Ser Cys Ala Glu Gln Leu Gly Phe Glu145 150 155 160Thr Lys Ala Leu Gly Ser Ala Gly Ala Lys Ala Met His Val Leu Leu

165 170 175Gly Asp Tyr Asp Ala Tyr Ile His Ala Gly Gly Gln Tyr Glu Trp Asp

180 185 190Ser Ala Ala Pro Val Gly Val Cys Lys Ala Ala Gly Leu His Cys Ser

195 200 205Arg Leu Asp Gly Ser Glu Leu Thr Tyr Asn Asn Lys Asp Thr Tyr Met

210 215 220Pro Asp Ile Leu Ile Cys Arg Pro Glu Leu Ala Asp Glu Leu Leu Glu225 230 235 240Met Cys Ala Lys Phe Tyr Glu Glu Asn Gly Thr Tyr

245250<210>7<211>875<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (859)<223>RXA01420<400>7cgaagttcac gactacaggc attacctggg tgctgatttt gcgcgagtaa agctgtggct 60gcggaatgcg ctgctcatcc acacgtggaa tcctgattgg gtg acg ctg ggt gga 115

Val Thr Leu Gly Gly

1 5ttg aat gta cca tcg tgg tcg ctg ggc gcg gaa atg ctg ttc tac ctg 163Leu Asn Val Pro Ser Trp Ser Leu Gly Ala Glu Met Leu Phe Tyr Leu

10 15 20acg ttc ccg ctg ttt att ccg tta gtg cgc aaa gtg aag ggc gtg ggc 211Thr Phe Pro Leu Phe Ile Pro Leu Val Arg Lys Val Lys Gly Val Gly

25 30 35aac tgg tgg gca ttt ggc atc acc ttt gcc gtg agc ctg gcg ctg att 259Asn Trp Trp Ala Phe Gly Ile Thr Phe Ala Val Ser Leu Ala Leu Ile

40 45 50aca gtg att cac ttt tat gcg gac gga cca aag ggg att gag aac ttc 307Thr Val Ile His Phe Tyr Ala Asp Gly Pro Lys Gly Ile Glu Asn Phe

55 60 65ttt gtt cct cgc ctg tgg gac acc aat gtg tca ccg gtc gcg gaa gtt 355Phe Val Pro Arg Leu Trp Asp Thr Asn Val Ser Pro Val Ala Glu Val 70 75 80 85cac gcc gat cca gtg tgg ttt atg cag gaa gaa att ccc gtg ctg gaa 403His Ala Asp Pro Val Trp Phe Met Gln Glu Glu Ile Pro Val Leu Glu

90 95 100tct tac tgg ctg tct tac tac ttc ccg ctg acc aga ctc atc gag ttc 451Ser Tyr Trp Leu Ser Tyr Tyr Phe Pro Leu Thr Arg Leu Ile Glu Phe

105 110 115tac ctc ggt gtg ttt ggc gcg aag ctg gtt gct gaa ggc atg ttt aaa 499Tyr Leu Gly Val Phe Gly Ala Lys Leu Val Ala Glu Gly Met Phe Lys

120 125 130aac acc aac atc acc atc ccg ctg atc gca ctg gct gtt tct ttt gtt 547Asn Thr Asn Ile Thr Ile Pro Leu Ile Ala Leu Ala Val Ser Phe Val

135 140 145gct act tgg ttt gtg cca ctg gca ttc aag atg tct gtc atc atg tcc 595Ala Thr Trp Phe Val Pro Leu Ala Phe Lys Met Ser Val Ile Met Ser150 155 160 165ctg cca atg gct ttt gtt gtg gca acg ctt gcg gtg aga gac att gaa 643Leu Pro Met Ala Phe Val Val Ala Thr Leu Ala Val Arg Asp Ile Glu

170 175 180ggc aag agt ggg gaa atc gcc tcg cct cgc gca gtt ttg ttg ggt aat 691Gly Lys Ser Gly Glu Ile Ala Ser Pro Arg Ala Val Leu Leu Gly Asn

185190 195att tcc ttt gcc ttc tac atg gtg caa ttc ccc gtc atg gtg ttt gtg 739Ile Ser Phe Ala Phe Tyr Met Val Gln Phe Pro Val Met Val Phe Val

200 205 210cag cgc tat ttc att gct ggc aaa gaa tac ggc ttc ctt ggc tgg gca 787Gln Arg Tyr Phe Ile Ala Gly Lys Glu Tyr Gly Phe Leu Gly Trp Ala

215 220 225ttc tat gca gtg gtg tgt ttc atc gtg tcg gtc att ctc gcg tgg gtg 835Phe Tyr Ala Val Val Cys Phe Ile Val Ser Val Ile Leu Ala Trp Val230 235 240 245ctg tta cct tcg ttg atg atc ctt taataaggcc acggaa 875Leu Leu Pro Ser Leu Met Ile Leu

250<210>8<211>253<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>8Val Thr Leu Gly Gly Leu Asn Val Pro Ser Trp Ser Leu Gly Ala Glu 151015 Met Leu Phe Tyr Leu Thr Phe Pro Leu Phe Ile Pro Leu Val Arg Lys

20 25 30Val Lys Gly Val Gly Asn Trp Trp Ala Phe Gly Ile Thr Phe Ala Val

35 40 45Ser Leu Ala Leu Ile Thr Val Ile His Phe Tyr Ala Asp Gly Pro Lys

50 55 60Gly Ile Glu Asn Phe Phe Val Pro Arg Leu Trp Asp Thr Asn Val Ser 65 70 75 80Pro Val Ala Glu Val His Ala Asp Pro Val Trp Phe Met Gln Glu Glu

85 90 95Ile Pro Val Leu Glu Ser Tyr Trp Leu Ser Tyr Tyr Phe Pro Leu Thr

100 105 110Arg Leu Ile Glu Phe Tyr Leu Gly Val Phe Gly Ala Lys Leu Val Ala

115 120 125Glu Gly Met Phe Lys Asn Thr Asn Ile Thr Ile Pro Leu Ile Ala Leu

130 135 140Ala Val Ser Phe Val Ala Thr Trp Phe Val Pro Leu Ala Phe Lys Met145 150 155 160Ser Val Ile Met Ser Leu Pro Met Ala Phe Val ValAla Thr Leu Ala

165 170 175Val Arg Asp Ile Glu Gly Lys Ser Gly Glu Ile Ala Ser Pro Arg Ala

180 185 190Val Leu Leu Gly Asn Ile Ser Phe Ala Phe Tyr Met Val Gln Phe Pro

195 200 205Val Met Val Phe Val Gln Arg Tyr Phe Ile Ala Gly Lys Glu Tyr Gly

210 215 220Phe Leu Gly Trp Ala Phe Tyr Ala Val Val Cys Phe Ile Val Ser Val225 230 235 240Ile Leu Ala Trp Val Leu Leu Pro Ser Leu Met Ile Leu

245250<210>9<211>1983<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1960)<223>RXN02581<400>9acggtcactc gctcaagtag tgttagtttg caaaagtaat aaaatgttca tctttgtcga 60tggtcacaat agtcattaaa gaattgtaag aggggttcac atg gat tta gat aaa 115

Met Asp Leu Asp Lys

1 5gcg att ggt tca ttc ttc gat gag aat gga gaa atc aac ctt cct cca 163Ala Ile Gly Ser Phe Phe Asp Glu Asn Gly Glu Ile Asn Leu Pro Pro

10 15 20ttc cta act ttg gca gcc atg ggt gag ttc atg tac cag gct gac atc 211Phe Leu Thr Leu Ala Ala Met Gly Glu Phe Met Tyr Gln Ala Asp Ile

25 30 35gct gaa ggc ggc ggg gat aaa cca cgc atgcat ttc tgg gac ttc tcc 259Ala Glu Gly Gly Gly Asp Lys Pro Arg Met His Phe Trp Asp Phe Ser

40 45 50gaa gac cgc gat ggc aag ctg att cag tac acc cga aac gag atc gat 307Glu Asp Arg Asp Gly Lys Leu Ile Gln Tyr Thr Arg Asn Glu Ile Asp

55 60 65act cgt atc aag gct gta gca ggc cgt ttg cag cag gtc gcc acc ctg 355Thr Arg Ile Lys Ala Val Ala Gly Arg Leu Gln Gln Val Ala Thr Leu 70 75 80 85ggt gat cgt gca gcg atc ctg gct aac aac agc cct gag tac att ttc 403Gly Asp Arg Ala Ala Ile Leu Ala Asn Asn Ser Pro Glu Tyr Ile Phe

90 95 100agc ttc ctc ggc gcg atc tac gct ggc atg gtc cct gtg ccg ctt tat 451Ser Phe Leu Gly Ala Ile Tyr Ala Gly Met Val Pro Val Pro Leu Tyr

105 110 115gat cca aac gag cca gga cac gca gac cac ctc aac gct gtt ttc gca 499Asp Pro Asn Glu Pro Gly His Ala Asp His Leu Asn Ala Val Phe Ala

120 125 130gac agc gag cca gtt gtc gtt ctg acc aac tcc aag tcc gca ggt gcc 547Asp Ser Glu Pro Val Val Val Leu Thr Asn Ser Lys Ser Ala Gly Ala

135 140 145gtg cgc aag cac ttc tcc agc ctt cca gct gca gaa cgc cca cgc atc 595Val Arg Lys His Phe Ser Ser Leu Pro Ala Ala Glu Arg Pro Arg Ile150 155 160 165ctc tct gta gat tcc ttg cct gat tct ctc gcg gat tct tac gag aac 643Leu Ser Val Asp Ser Leu Pro Asp Ser Leu Ala Asp Ser Tyr Glu Asn

170 175 180cca atg ctg acc gaa gcc ggc cgc cgc ctg gct gct ctg cgc cag tcc 691Pro Met Leu Thr Glu Ala Gly Arg Arg Leu Ala Ala Leu Arg Gln Ser

185 190 195gcg ccc att gat ctg acc gca ttc ctg cag tac acc tcc ggc tcc acc 739Ala Pro Ile Asp Leu Thr Ala Phe Leu Gln Tyr Thr Ser Gly Ser Thr

200 205 210cga acc cca gct ggc gtt gtt ctg acc aac cgc tcc atc ctg acc aac 787Arg Thr Pro Ala Gly Val Val Leu Thr Asn Arg Ser Ile Leu Thr Asn

215 220 225gtc ttg cag atc ttc agc gcc gca cag ctg aaa acc cca ctg cgc ctg 835Val Leu Gln Ile Phe Ser Ala Ala Gln Leu Lys Thr Pro Leu Arg Leu230 235 240 245gtt tca tgg ctg cca ctg cac cac gac atg ggc att atc ctc gcg gcg 883Val Ser Trp Leu Pro Leu His His Asp Met Gly Ile Ile Leu Ala Ala

250 255 260ttt gtc act atg ctt ggc ctg gac aac gag ttc atg aac cca cgc gat 931Phe Val Thr Met Leu Gly Leu Asp Asn Glu Phe Met Asn Pro Arg Asp

265 270 275ttc gtg cag cag cct tcc cgc tgg att aag cag ctc aac cgt cgc gaa 979Phe Val Gln Gln Pro Ser Arg Trp Ile Lys Gln Leu Asn Arg Arg Glu

280 285 290agc gac gtg gac gtt aac gtc tac acc gtg gtt cct aac ttc gcc ctc 1027Ser Asp Val Asp Val Asn Val Tyr Thr Val Val Pro Asn Phe Ala Leu

295 300 305gag ctt gca gca cgc tac gca aag cca gca gag gga gag acc ctg gat 1075Glu Leu Ala Ala Arg Tyr Ala Lys Pro Ala Glu Gly Glu Thr Leu Asp310 315 320 325ctt tcc gca ttg gat gcc atc att atc ggt tcc gag cca gtc aca gaa 1123Leu Ser Ala Leu Asp Ala Ile Ile Ile Gly Ser Glu Pro Val Thr Glu

330 335 340aac gct ctg acc acc ttc cgt gaa gct ttc gag cct tac ggc ctg cct 1171Asn Ala Leu Thr Thr Phe Arg Glu Ala Phe Glu Pro Tyr Gly Leu Pro

345 350 355gtt cag acc ctg cgt cct tcc tac ggt ctt gca gaa gca tcc ctg ctg 1219Val Gln Thr Leu Arg Pro Ser Tyr Gly Leu Ala Glu Ala Ser Leu Leu

360 365 370gtc acc acc cca cag acc gaa aac cgc cca ctg atc tcc tac ttc gac 1267Val Thr Thr Pro Gln Thr Glu Asn Arg Pro Leu Ile Ser Tyr Phe Asp

375 380 385cgc gag gcc ttg gcc gaa aac cgc gtt gag ctt gta gaa aag ggc aat 1315Arg Glu Ala Leu Ala Glu Asn Arg Val Glu Leu Val Glu Lys Gly Asn390 395 400 405aac aag gct gtt gct ttc gtc tcc aac ggc cag gtt gca gcc cca cag 1363Asn Lys Ala Val Ala Phe Val Ser Asn Gly Gln Val Ala Ala Pro Gln

410 415 420cag ctg gtc atc gtt gat tcc gaa acc gga acc gag ctg gca gac ggc 1411Gln Leu Val Ile Val Asp Ser Glu Thr Gly Thr Glu Leu Ala Asp Gly

425 430 435cag atc ggc gaa atc tgg acc cac ggc gaa aac act gct gca ggt tac 1459Gln Ile Gly Glu Ile Trp Thr His Gly Glu Asn Thr Ala Ala Gly Tyr

440 445 450ctc gac cgc gag gaa gac acc gca gaa acc ttc cgc aac cgt ctg acc 1507Leu Asp Arg Glu Glu Asp Thr Ala Glu Thr Phe Arg Asn Arg Leu Thr

455 460 465acc cgc ctg gaa gaa aac tcc cgc gca gaa ggt gct gcc gac gac aac 1555Thr Arg Leu Glu Glu Asn Ser Arg Ala Glu Gly Ala Ala Asp Asp Asn470 475 480 485tac tgg atg gcc acc ggt gac ctc ggc gtc atc gta gac aac gag ctc 1603Tyr Trp Met Ala Thr Gly Asp Leu Gly Val Ile Val Asp Asn Glu Leu

490495 500tac atc acc ggt cgt ctg aag gac ctc atc gtt gtc gca ggc cga aac 1651Tyr Ile Thr Gly Arg Leu Lys Asp Leu Ile Val Val Ala Gly Arg Asn

505 510 515cac tac cca cag gac atc gag tac acc gtc cag gct gct tcc gca cac 1699His Tyr Pro Gln Asp Ile Glu Tyr Thr Val Gln Ala Ala Ser Ala His

520 525 530atc cgt gca gat tcc gtc gca gca ttc gca gtc cca ggc gat gac att 1747Ile Arg Ala Asp Ser Val Ala Ala Phe Ala Val Pro Gly Asp Asp Ile

535 540 545gaa aag ctc atc atc ctg gca gaa cgc gac acc act gca aac gaa gcc 1795Glu Lys Leu Ile Ile Leu Ala Glu Arg Asp Thr Thr Ala Asn Glu Ala550 555 560 565gac gat gca gct gct gaa gaa gca atc cgc tcc gcc gtt ggc act gca 1843Asp Asp Ala Ala Ala Glu Glu Ala Ile Arg Ser Ala Val Gly Thr Ala

570 575 580cac ggt gtt gtt cca gaa gag atc cgt atc ctc gca cct gac gag atc 1891His Gly Val Val Pro Glu Glu Ile Arg Ile Leu Ala Pro Asp Glu Ile

585 590 595gcg cgt tcc tcc tcc gga aag atc gca cgc cgc gtc aac cag cgc aac 1939Ala Arg Ser Ser Ser Gly Lys Ile Ala Arg Arg Val Asn Gln Arg Asn

600 605 610tac att cag gaa caa gct aac tagttctttg cagacaccgc agg 1983Tyr Ile Gln Glu Gln Ala Asn

615620<210>10<211>620<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>10Met Asp Leu Asp Lys Ala Ile Gly Ser Phe Phe Asp Glu Asn Gly Glu 151015 Ile Asn Leu Pro Pro Phe Leu Thr Leu Ala Ala Met Gly Glu Phe Met

20 25 30TyrGln Ala Asp Ile Ala Glu Gly Gly Gly Asp Lys Pro Arg Met His

35 40 45Phe Trp Asp Phe Ser Glu Asp Arg Asp Gly Lys Leu Ile Gln Tyr Thr

50 55 60Arg Asn Glu Ile Asp Thr Arg Ile Lys Ala Val Ala Gly Arg Leu Gln 65 70 75 80Gln Val Ala Thr Leu Gly Asp Arg Ala Ala Ile Leu Ala Asn Asn Ser

85 90 95Pro Glu Tyr Ile Phe Ser Phe Leu Gly Ala Ile Tyr Ala Gly Met Val

100 105 110Pro Val Pro Leu Tyr Asp Pro Asn Glu Pro Gly His Ala Asp His Leu

115 120 125Asn Ala Val Phe Ala Asp Ser Glu Pro Val Val Val Leu Thr Asn Ser

130 135 140Lys Ser Ala Gly Ala Val Arg Lys His Phe Ser Ser Leu Pro Ala Ala145 150 155 160Glu Arg Pro Arg Ile Leu Ser Val Asp Ser Leu Pro Asp Ser Leu Ala

165 170 175Asp Ser Tyr Glu Asn Pro Met Leu Thr Glu Ala Gly Arg Arg Leu Ala

180 185 190Ala Leu Arg Gln Ser Ala Pro Ile Asp Leu Thr Ala Phe Leu Gln Tyr

195 200 205Thr Ser Gly Ser Thr Arg Thr Pro Ala Gly Val Val Leu Thr Asn Arg

210 215 220Ser Ile Leu Thr Asn Val Leu Gln Ile Phe Ser Ala Ala Gln Leu Lys225 230 235 240Thr Pro Leu Arg Leu Val Ser Trp Leu Pro Leu His His Asp Met Gly

245 250 255Ile Ile Leu Ala Ala Phe Val Thr Met Leu Gly Leu Asp Asn Glu Phe

260 265 270Met Asn Pro Arg Asp Phe Val Gln Gln Pro Ser Arg Trp Ile Lys Gln

275 280 285Leu Asn Arg Arg Glu Ser Asp Val Asp Val Asn Val Tyr Thr Val Val

290 295 300Pro Asn Phe Ala Leu Glu Leu Ala Ala Arg Tyr Ala Lys Pro Ala Glu305 310 315 320Gly Glu Thr Leu Asp Leu Ser Ala Leu Asp Ala Ile Ile Ile Gly Ser

325 330 335Glu Pro Val Thr Glu Asn Ala Leu Thr Thr Phe Arg Glu Ala Phe Glu

340 345 350Pro Tyr Gly Leu Pro Val Gln Thr Leu Arg Pro Ser Tyr Gly Leu Ala

355 360 365Glu Ala Ser Leu Leu Val Thr Thr Pro Gln Thr Glu Asn Arg Pro Leu

370 375 380Ile Ser Tyr Phe Asp Arg Glu Ala Leu Ala Glu Asn Arg Val Glu Leu385 390 395 400Val Glu Lys Gly Asn Asn Lys Ala Val Ala Phe Val Ser Asn Gly Gln

405 410 415Val Ala Ala Pro Gln Gln Leu Val Ile Val Asp Ser Glu Thr Gly Thr

420 425 430Glu Leu Ala Asp Gly Gln Ile Gly Glu Ile Trp Thr His Gly Glu Asn

435 440 445Thr Ala Ala Gly Tyr Leu Asp Arg Glu Glu Asp Thr Ala Glu Thr Phe

450 455 460Arg Asn Arg Leu Thr Thr Arg Leu Glu Glu Asn Ser Arg Ala Glu Gly465 470 475 480Ala Ala Asp Asp Asn Tyr Trp Met Ala Thr Gly Asp LeuGly Val Ile

485 490 495Val Asp Asn Glu Leu Tyr Ile Thr Gly Arg Leu Lys Asp Leu Ile Val

500 505 510Val Ala Gly Arg Asn His Tyr Pro Gln Asp Ile Glu Tyr Thr Val Gln

515 520 525Ala Ala Ser Ala His Ile Arg Ala Asp Ser Val Ala Ala Phe Ala Val

530 535 540Pro Gly Asp Asp Ile Glu Lys Leu Ile Ile Leu Ala Glu Arg Asp Thr545 550 555 560Thr Ala Asn Glu Ala Asp Asp Ala Ala Ala Glu Glu Ala Ile Arg Ser

565 570 575Ala Val Gly Thr Ala His Gly Val Val Pro Glu Glu Ile Arg Ile Leu

580 585 590Ala Pro Asp Glu Ile Ala Arg Ser Ser Ser Gly Lys Ile Ala Arg Arg

595 600 605Val Asn Gln Arg Asn Tyr Ile Gln Glu Gln Ala Asn

610615620<210>11<211>1550<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (1527)<223>FRXA02581<400>11gtc cct gtg ccg ctt tat gat cca aac gag cca gga cac gca gac cac 48Val Pro Val Pro Leu Tyr Asp Pro Asn Glu Pro Gly His Ala Asp His 151015 ctc aac gct gtt ttc gca gac agc gag cca gtt gtc gtt ctg acc aac 96Leu Asn Ala Val Phe Ala Asp Ser Glu Pro Val Val Val Leu Thr Asn

20 25 30tcc aag tcc gca ggt gcc gtg cgc aag cac ttc tcc agc ctt cca gct 144Ser Lys Ser Ala Gly Ala Val Arg Lys His Phe Ser Ser Leu Pro Ala

35 40 45gca gaa cgc cca cgc atc ctc tct gta gat tcc ttg cct gat tct ctc 192Ala Glu Arg Pro Arg Ile Leu Ser Val Asp Ser Leu Pro Asp Ser Leu

50 55 60gcg gat tct tac gag aac cca atg ctg acc gaa gcc ggc cgc cgc ctg 240Ala Asp Ser Tyr Glu Asn Pro Met Leu Thr Glu Ala Gly Arg Arg Leu 65 70 75 80gct gct ctg cgc cag tcc gcg ccc att gat ctg acc gca ttc ctg cag 288Ala Ala Leu Arg Gln Ser Ala Pro Ile Asp Leu Thr Ala Phe Leu Gln

85 90 95tac acc tcc ggc tcc acc cga acc cca gct ggc gtt gtt ctg acc aac 336Tyr Thr Ser Gly Ser Thr Arg Thr Pro Ala Gly Val Val Leu Thr Asn

100 105 110cgc tcc atc ctg acc aac gtc ttg cag atc ttc agc gcc gca cag ctg 384Arg Ser Ile Leu Thr Asn Val Leu Gln Ile Phe Ser Ala Ala Gln Leu

115 120 125aaa acc cca ctg cgc ctg gtt tca tgg ctg cca ctg cac cac gac atg 432Lys Thr Pro Leu Arg Leu Val Ser Trp Leu Pro Leu His His Asp Met

130 135 140ggc att atc ctc gcg gcg ttt gtc act atg ctt ggc ctg gac aac gag 480Gly Ile Ile Leu Ala Ala Phe Val Thr Met Leu Gly Leu Asp Asn Glu145 150 155 160ttc atg aac cca cgc gat ttc gtg cag cag cct tcc cgc tgg att aag 528Phe Met Asn Pro Arg Asp Phe Val Gln Gln Pro Ser Arg Trp Ile Lys

165 170 175cag ctc aac cgt cgc gaa agc gac gtg gac gtt aac gtc tac acc gtg 576Gln Leu Asn Arg Arg Glu Ser Asp Val Asp Val Asn Val Tyr Thr Val

180 185 190gtt cct aac ttc gcc ctc gag ctt gca gca cgc tac gca aag cca gca 624Val Pro Asn Phe Ala Leu Glu Leu Ala Ala Arg Tyr Ala Lys Pro Ala

195200 205gag gga gag acc ctg gat ctt tcc gca ttg gat gcc atc att atc ggt 672Glu Gly Glu Thr Leu Asp Leu Ser Ala Leu Asp Ala Ile Ile Ile Gly

210 215 220tcc gag cca gtc aca gaa aac gct ctg acc acc ttc cgt gaa gct ttc 720Ser Glu Pro Val Thr Glu Asn Ala Leu Thr Thr Phe Arg Glu Ala Phe225 230 235 240gag cct tac ggc ctg cct gtt cag acc ctg cgt cct tcc tac ggt ctt 768Glu Pro Tyr Gly Leu Pro Val Gln Thr Leu Arg Pro Ser Tyr Gly Leu

245 250 255gca gaa gca tcc ctg ctg gtc acc acc cca cag acc gaa aac cgc cca 816Ala Glu Ala Ser Leu Leu Val Thr Thr Pro Gln Thr Glu Asn Arg Pro

260 265 270ctg atc tcc tac ttc gac cgc gag gcc ttg gcc gaa aac cgc gtt gag 864Leu Ile Ser Tyr Phe Asp Arg Glu Ala Leu Ala Glu Asn Arg Val Glu

275 280 285ctt gta gaa aag ggc aat aac aag gct gtt gct ttc gtc tcc aac ggc 912Leu Val Glu Lys Gly Asn Asn Lys Ala Val Ala Phe Val Ser Asn Gly

290 295 300cag gtt gca gcc cca cag cag ctg gtc atc gtt gat tcc gaa acc gga 960Gln Val Ala Ala Pro Gln Gln Leu Val Ile Val Asp Ser Glu Thr Gly305 310 315 320acc gag ctg gca gac ggc cag atc ggc gaa atc tgg acc cac ggc gaa 1008Thr Glu Leu Ala Asp Gly Gln Ile Gly Glu Ile Trp Thr His Gly Glu

325 330 335aac act gct gca ggt tac ctc gac cgc gag gaa gac acc gca gaa acc 1056Asn Thr Ala Ala Gly Tyr Leu Asp Arg Glu Glu Asp Thr Ala Glu Thr

340 345 350ttc cgc aac cgt ctg acc acc cgc ctg gaa gaa aac tcc cgc gca gaa 1104Phe Arg Asn ArgLeu Thr Thr Arg Leu Glu Glu Asn Ser Arg Ala Glu

355 360 365ggt gct gcc gac gac aac tac tgg atg gcc acc ggt gac ctc ggc gtc 1152Gly Ala Ala Asp Asp Asn Tyr Trp Met Ala Thr Gly Asp Leu Gly Val

370 375 380atc gta gac aac gag ctc tac atc acc ggt cgt ctg aag gac ctc atc 1200Ile Val Asp Asn Glu Leu Tyr Ile Thr Gly Arg Leu Lys Asp Leu Ile385 390 395 400gtt gtc gca ggc cga aac cac tac cca cag gac atc gag tac acc gtc 1248Val Val Ala Gly Arg Asn His Tyr Pro Gln Asp Ile Glu Tyr Thr Val

405 410 415cag gct gct tcc gca cac atc cgt gca gat tcc gtc gca gca ttc gca 1296Gln Ala Ala Ser Ala His Ile Arg Ala Asp Ser Val Ala Ala Phe Ala

420 425 430gtc cca ggc gat gac att gaa aag ctc atc atc ctg gca gaa cgc gac 1344Val Pro Gly Asp Asp Ile Glu Lys Leu Ile Ile Leu Ala Glu Arg Asp

435 440 445acc act gca aac gaa gcc gac gat gca gct gct gaa gaa gca atc cgc 1392Thr Thr Ala Asn Glu Ala Asp Asp Ala Ala Ala Glu Glu Ala Ile Arg

450 455 460tcc gcc gtt ggc act gca cac ggt gtt gtt cca gaa gag atc cgt atc 1440Ser Ala Val Gly Thr Ala His Gly Val Val Pro Glu Glu Ile Arg Ile465 470 475 480ctc gca cct gac gag atc gcg cgt tcc tcc tcc gga aag atc gca cgc 1488Leu Ala Pro Asp Glu Ile Ala Arg Ser Ser Ser Gly Lys Ile Ala Arg

485 490 495cgc gtc aac cag cgc aac tac att cag gaa caa gct aac tagttctttg 1537Arg Val Asn Gln Arg Asn Tyr Ile Gln Glu Gln Ala Asn

500505 cagacaccgc agg 1550<210>12<211>509<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>12Val Pro Val Pro Leu Tyr Asp Pro Asn Glu Pro Gly His Ala Asp His 151015 Leu Asn Ala Val Phe Ala Asp Ser Glu Pro Val Val Val Leu Thr Asn

20 25 30Ser Lys Ser Ala Gly Ala Val Arg Lys His Phe Ser Ser Leu Pro Ala

35 40 45Ala Glu Arg Pro Arg Ile Leu Ser Val Asp Ser Leu Pro Asp Ser Leu

50 55 60Ala Asp Ser Tyr Glu Asn Pro Met Leu Thr Glu Ala Gly Arg Arg Leu 65 70 75 80Ala Ala Leu Arg Gln Ser Ala Pro Ile Asp Leu Thr Ala Phe Leu Gln

85 90 95Tyr Thr Ser Gly Ser Thr Arg Thr Pro Ala Gly Val Val Leu Thr Asn

100 105 110Arg Ser Ile Leu Thr Asn Val Leu Gln Ile Phe Ser Ala Ala Gln Leu

115 120 125Lys Thr Pro Leu Arg Leu Val Ser Trp Leu Pro Leu His His Asp Met

130 135 140Gly Ile Ile Leu Ala Ala Phe Val Thr Met Leu Gly Leu Asp Asn Glu145 150 155 160Phe Met Asn Pro Arg Asp Phe Val Gln Gln Pro Ser Arg Trp Ile Lys

165 170 175Gln Leu Asn Arg Arg Glu Ser Asp Val Asp Val Asn Val Tyr Thr Val

180 185 190Val Pro Asn Phe Ala Leu Glu Leu Ala Ala Arg Tyr Ala Lys Pro Ala

195 200 205Glu Gly Glu Thr Leu Asp Leu Ser Ala Leu Asp Ala Ile Ile Ile Gly

210 215220Ser Glu Pro Val Thr Glu Asn Ala Leu Thr Thr Phe Arg Glu Ala Phe225 230 235 240Glu Pro Tyr Gly Leu Pro Val Gln Thr Leu Arg Pro Ser Tyr Gly Leu

245 250 255Ala Glu Ala Ser Leu Leu Val Thr Thr Pro Gln Thr Glu Asn Arg Pro

260 265 270Leu Ile Ser Tyr Phe Asp Arg Glu Ala Leu Ala Glu Asn Arg Val Glu

275 280 285Leu Val Glu Lys Gly Asn Asn Lys Ala Val Ala Phe Val Ser Asn Gly

290 295 300Gln Val Ala Ala Pro Gln Gln Leu Val Ile Val Asp Ser Glu Thr Gly305 310 315 320Thr Glu Leu Ala Asp Gly Gln Ile Gly Glu Ile Trp Thr His Gly Glu

325 330 335Asn Thr Ala Ala Gly Tyr Leu Asp Arg Glu Glu Asp Thr Ala Glu Thr

340 345 350Phe Arg Asn Arg Leu Thr Thr Arg Leu Glu Glu Asn Ser Arg Ala Glu

355 360 365Gly Ala Ala Asp Asp Asn Tyr Trp Met Ala Thr Gly Asp Leu Gly Val

370 375 380Ile Val Asp Asn Glu Leu Tyr Ile Thr Gly Arg Leu Lys Asp Leu Ile385 390 395 400Val Val Ala Gly Arg Asn His Tyr Pro Gln Asp Ile Glu Tyr Thr Val

405 410 415Gln Ala Ala Ser Ala His Ile Arg Ala Asp Ser Val Ala Ala Phe Ala

420 425 430Val Pro Gly Asp Asp Ile Glu Lys Leu Ile Ile Leu Ala Glu Arg Asp

435 440 445Thr Thr Ala Asn Glu Ala Asp Asp Ala Ala Ala Glu Glu Ala Ile Arg

450 455 460Ser Ala Val Gly Thr Ala His Gly Val Val Pro Glu Glu Ile Arg Ile465 470 475 480Leu Ala Pro Asp Glu Ile Ala Arg Ser Ser Ser Gly Lys Ile Ala Arg

485 490 495Arg Val Asn Gln Arg Asn Tyr Ile Gln Glu Gln Ala Asn

500505<210>13<211>4953<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (4930)<223>RXA02582<400>13tggatgtcta ttctcctcag cctcgttttg gttgaggcgg atagttttaa tattttttta 60agtttaagtt gtaatcgagc tgaaaggctg aggcctcaat atg gaa cag agc caa 115

Met Glu Gln Ser Gln

1 5tcg tcg gat cag aag atg acc gtt gaa cag gtt cgc acc tgg ctc cgt 163Ser Ser Asp Gln Lys Met Thr Val Glu Gln Val Arg Thr Trp Leu Arg

10 15 20gat tgg gtt gtc cgc acc acg ggt att ccg gtg gag gaa gtt acg gat 211Asp Trp Val Val Arg Thr Thr Gly Ile Pro Val Glu Glu Val Thr Asp

25 30 35gac aag gca atg gag acc ttt ggc ctt tcc tct cgc gat gtt gtt gtg 259Asp Lys Ala Met Glu Thr Phe Gly Leu Ser Ser Arg Asp Val Val Val

40 45 50ttg tct ggt gag ctg gaa aac ctg ctg gac acc tcc ttg gat gcc acc 307Leu Ser Gly Glu Leu Glu Asn Leu Leu Asp Thr Ser Leu Asp Ala Thr

55 60 65atc gct tat gag tac cca acg atc cgt agt ttg gcg cag cgc ctt gtt 355Ile Ala Tyr Glu Tyr Pro Thr Ile Arg Ser LeuAla Gln Arg Leu Val 70 75 80 85gag ggc gag cct cgt cgt gca cat acc cag cgt gaa ttg aat ttc tcc 403Glu Gly Glu Pro Arg Arg Ala His Thr Gln Arg Glu Leu Asn Phe Ser

90 95 100gcg gtg agc gat tcc cca ggt tcc cac gat att gcg gtt gtc ggt atg 451Ala Val Ser Asp Ser Pro Gly Ser His Asp Ile Ala Val Val Gly Met

105 110 115gct gcg cgt tac cca ggc gct gag agc ctg gag gat atg tgg aag cta 499Ala Ala Arg Tyr Pro Gly Ala Glu Ser Leu Glu Asp Met Trp Lys Leu

120 125 130ctc gtc gag ggc cgt gac ggt atc tcg gat cta ccg att ggc cgt tgg 547Leu Val Glu Gly Arg Asp Gly Ile Ser Asp Leu Pro Ile Gly Arg Trp

135 140 145tct gag tat gca ggc gat gag gtt atg tct cgg aag atg gaa gag ttt 595Ser Glu Tyr Ala Gly Asp Glu Val Met Ser Arg Lys Met Glu Glu Phe150 155 160 165tct acc atc ggt ggc tac ctg tca gat atc tct agc ttt gat gcg gag 643Ser Thr Ile Gly Gly Tyr Leu Ser Asp Ile Ser Ser Phe Asp Ala Glu

170 175 180ttc ttt ggt ctg tct ccg ctc gag gcc gcc aac atg gat cct cag cag 691Phe Phe Gly Leu Ser Pro Leu Glu Ala Ala Asn Met Asp Pro Gln Gln

185 190 195cgt att ttg ctg gag cta acg tgg gag gct ttg gag tac gct cgc atc 739Arg Ile Leu Leu Glu Leu Thr Trp Glu Ala Leu Glu Tyr Ala Arg Ile

200 205 210gca cca aac act ttg cgt ggc gaa gcc gtg ggc gtg ttc ata ggt tcc 787Ala Pro Asn Thr Leu Arg Gly Glu Ala Val Gly Val Phe Ile Gly Ser

215 220 225tcc aac aac gat tac ggc atg atg atc gct gcc gat cca gca gaa gca 835Ser Asn Asn Asp Tyr Gly Met Met Ile Ala Ala Asp Pro Ala Glu Ala230 235 240 245cat cct tat gcg ctg act ggt act tct agt gcg att gtc gct aac cgc 883His Pro Tyr Ala Leu Thr Gly Thr Ser Ser Ala Ile Val Ala Asn Arg

250 255 260att aac tac gct ttc gat ttc cgc ggt cct tcc gtc aac gtg gat acc 931Ile Asn Tyr Ala Phe Asp Phe Arg Gly Pro Ser Val Asn Val Asp Thr

265 270 275gca tgt tct tct tct ctg gta gcg gtt cac cag gct gtc cgt gcg ctg 979Ala Cys Ser Ser Ser Leu Val Ala Val His Gln Ala Val Arg Ala Leu

280 285 290cgt aat ggc gaa gcg gat cac gct atc gct ggt gga gtg aac att ttg 1027Arg Asn Gly Glu Ala Asp His Ala Ile Ala Gly Gly Val Asn Ile Leu

295 300 305gca tct cca ttt gtc aca act gca ttc gct gag ctc ggt gtg atc agc 1075Ala Ser Pro Phe Val Thr Thr Ala Phe Ala Glu Leu Gly Val Ile Ser310 315 320 325cca acc ggc aag atc cac gca ttc tct gat gat gcc gat ggt ttc gtg 1123Pro Thr Gly Lys Ile His Ala Phe Ser Asp Asp Ala Asp Gly Phe Val

330 335 340cgt tcc gac ggc gcc gga gtc gtt gtg ctg aag cgc gtg gat gac gca 1171Arg Ser Asp Gly Ala Gly Val Val Val Leu Lys Arg Val Asp Asp Ala

345 350 355atc cgc gac ggc gac aag atc atc ggt gtg atc aag ggt tct gca gtg 1219Ile Arg Asp Gly Asp Lys Ile Ile Gly Val Ile Lys Gly Ser Ala Val

360 365 370aac tcc gat ggt cac tcc aac gga ctg acc gct cca aac cct gac gca 1267Asn Ser Asp Gly His Ser Asn Gly Leu Thr Ala Pro Asn Pro Asp Ala

375 380 385cag gtt gat gtg ctg cag cgt gca tat gtt gac gct cag gtt gat ccc 1315Gln Val Asp Val Leu Gln Arg Ala Tyr Val Asp Ala Gln Val Asp Pro390 395 400 405acc acc gtg gat tac gtt gag gct cac ggc acc ggc acc atc ctg ggt 1363Thr Thr Val Asp Tyr Val Glu Ala His Gly Thr Gly Thr Ile Leu Gly

410 415 420gac ccc att gaa gca act gcc ctg ggt gct gtt ttg ggc tat ggc cgt 1411Asp Pro Ile Glu Ala Thr Ala Leu Gly Ala Val Leu Gly Tyr Gly Arg

425 430 435gac gca tcc acc cca act ctt ctg ggc tct gca aag tcc aac ttc ggc 1459Asp Ala Ser Thr Pro Thr Leu Leu Gly Ser Ala Lys Ser Asn Phe Gly

440 445 450cac act gag tca gct gcg ggt att gca ggt gtc atc aag gtg ctg ctt 1507His Thr Glu Ser Ala Ala Gly Ile Ala Gly Val Ile Lys Val Leu Leu

455 460 465gct ttg cag aac aag act ctg cca cca acc gtg aac ttt gca ggt cca 1555Ala Leu Gln Asn Lys Thr Leu Pro Pro Thr Val Asn Phe Ala Gly Pro470 475 480 485aac cgc tac atc gat ttc gat gct gag cgt ttg gaa gtt gtg gaa gat 1603Asn Arg Tyr Ile Asp Phe Asp Ala Glu Arg Leu Glu Val Val Glu Asp

490 495 500cca cgt gaa tgg ccg gaa tac aac ggt cac gca gta gct ggt gtg tct 1651Pro Arg Glu Trp Pro Glu Tyr Asn Gly His Ala Val Ala Gly Val Ser

505 510 515gcg ttc ggg ttc ggt gga acc aac gcg cac gtg gtg atc tct gag tac 1699Ala Phe Gly Phe Gly Gly Thr Asn Ala His Val Val Ile Ser Glu Tyr

520 525 530aac gca gaa gac tac gaaacc cgt gcc ccg aag gag gcg ttg ctt cct 1747Asn Ala Glu Asp Tyr Glu Thr Arg Ala Pro Lys Glu Ala Leu Leu Pro

535 540 545gac cag cag gtt gcc ctg ccg gtg tct ggt cac ctg cca tcc agg cgt 1795Asp Gln Gln Val Ala Leu Pro Val Ser Gly His Leu Pro Ser Arg Arg550 555 560 565cga caa gca gct gct gac ttg gcg gac ttc ttg gag ggc cgc aaa gat 1843Arg Gln Ala Ala Ala Asp Leu Ala Asp Phe Leu Glu Gly Arg Lys Asp

570 575 580tgc gac cta acc cca gta gcc cgc gcg ctg gca ggc cgc aat cat ggc 1891Cys Asp Leu Thr Pro Val Ala Arg Ala Leu Ala Gly Arg Asn His Gly

585 590 595cgc tcc cgc gca gtc gtg ctt gca agc act atc gag gaa gcc gta aag 1939Arg Ser Arg Ala Val Val Leu Ala Ser Thr Ile Glu Glu Ala Val Lys

600 605 610cgc ctg cgc cag gtc gca gaa ggc aag gtc agc gtc ggt ate tcc gca 1987Arg Leu Arg Gln Val Ala Glu Gly Lys Val Ser Val Gly Ile Ser Ala

615 620 625gct gat tcc cca gcg gcc aac ggt cct gtg ttt gtg tac tcc ggt ttc 2035Ala Asp Ser Pro Ala Ala Asn Gly Pro Val Phe Val Tyr Ser Gly Phe630 635 640 645gga tcc cag cac cgc ctc atg atc aag gaa ttg tgc tca att tcg cca 2083Gly Ser Gln His Arg Leu Met Ile Lys Glu Leu Cys Ser Ile Ser Pro

650 655 660cag ttc cgc gag cgc atc gaa gag ctc gat gaa atg gtt aag ttc gag 2131Gln Phe Arg Glu Arg Ile Glu Glu Leu Asp Glu Met Val Lys Phe Glu

665 670 675tcc ggc tgg tcc arc atg aaa crt gtt ttg gat gat gag caa act tac 2179Ser Gly Trp Ser Ile Met Lys Leu Val Leu Asp Asp Glu Gln Thr Tyr

680 685 690gac acc gag acc gcg cag gtt gtg atc acc gca atc cag atc gca ctg 2227Asp Thr Glu Thr Ala Gln Val Val Ile Thr Ala Ile Gln Ile Ala Leu

695 700 705act gac ctg ttg gca agc ttc ggt gta aag cca gct gcc gtc atg ggc 2275Thr Asp Leu Leu Ala Ser Phe Gly Val Lys Pro Ala Ala Val Met Gly710 715 720 725atg tcg atg ggt gag atc gct gcc gct tac gct gcc ggt gga ctc agc 2323Met Ser Met Gly Glu Ile Ala Ala Ala Tyr Ala Ala Gly Gly Leu Ser

730 735 740gac cgc gat acc atg ctc att gcc agc cac cgt tcc cgc cta atg ggc 2371Asp Arg Asp Thr Met Leu Ile Ala Ser His Arg Ser Arg Leu Met Gly

745 750 755gag ggc gag aag tcc ctg gct gag gat cag ctg ggt gcc atg gct gtg 2419Glu Gly Glu Lys Ser Leu Ala Glu Asp Gln Leu Gly Ala Met Ala Val

760 765 770gtg gaa ttc gcc gct gcg gac ctg gat aag ttc atc gaa gaa aac cct 2467Val Glu Phe Ala Ala Ala Asp Leu Asp Lys Phe Ile Glu Glu Asn Pro

775 780 785gag tac aag ggc att gag cct gct gtt tat gca ggc cca ggc atg act 2515Glu Tyr Lys Gly Ile Glu Pro Ala Val Tyr Ala Gly Pro Gly Met Thr790 795 800 805acc gtg ggt gga cct cgc gac gcc gtg gtt cag ttc gta gag aag ctg 2563Thr Val Gly Gly Pro Arg Asp Ala Val Val Gln Phe Val Glu Lys Leu

810 815 820gaa tct gaa gac aag ttt gcc cgc ctg ctc aac gtc aag ggc gct ggc 2611Glu Ser Glu Asp Lys Phe Ala Arg Leu Leu Asn Val Lys Gly Ala Gly

825 830 835cac acc tct gct gtg gaa cca ctt ctt ggtgag ctc gct ggc gaa atc 2659His Thr Ser Ala Val Glu Pro Leu Leu Gly Glu Leu Ala Gly Glu Ile

840 845 850gct ggc atc gag cca ctt ccg ctg cag atc ccg ttg ttc agc tct gtc 2707Ala Gly Ile Glu Pro Leu Pro Leu Gln Ile Pro Leu Phe Ser Ser Val

855 860 865gat cag ggt gtt acc tac cca gtt gga gca gtg gtc cac gac gcc gat 2755Asp Gln Gly Val Thr Tyr Pro Val Gly Ala Val Val His Asp Ala Asp870 875 880 885tac atg ctc cgc tgt acc cgc cag tcc gtg tac ttc cag gac tcc acc 2803Tyr Met Leu Arg Cys Thr Arg Gln Ser Val Tyr Phe Gln Asp Ser Thr

890 895 900gaa gct gca ttc gct gca ggc cac aac acc ttg gtg gaa att tcc ccg 2851Glu Ala Ala Phe Ala Ala Gly His Asn Thr Leu Val Glu Ile Ser Pro

905 910 915aac cca gtt gca ctc atg ggc atg atg aac acc gcg ttc acc gtg ggc 2899Asn Pro Val Ala Leu Met Gly Met Met Asn Thr Ala Phe Thr Val Gly

920 925 930aag cct gat gca cag ctg ctg ttc agc ctg aag cga aaa gtc cca gag 2947Lys Pro Asp Ala Gln Leu Leu Phe Ser Leu Lys Arg Lys Val Pro Glu

935 940 945gca gaa tcc ctc cgc gac ctt ctg gcg aag ctg tac gtc aac ggc gca 2995Ala Glu Ser Leu Arg Asp Leu Leu Ala Lys Leu Tyr Val Asn Gly Ala950 955 960 965aac gtt gat ttc tcc gcg ctg tac ggc gaa ggt gaa acc atc gat ccg 3043Asn Val Asp Phe Ser Ala Leu Tyr Gly Glu Gly Glu Thr Ile Asp Pro

970 975 980cca cac atc acc tgg aag cac cag cgc ttc tgg act tcc gca cgc cca 3091Pro His Ile Thr Trp Lys His Gln Arg Phe Trp Thr Ser Ala Arg Pro

985 990 995tcc tct ggc gca tcc ctg gat ctg ccg ggc ttc cgc gtg aat ctg cca 3139Ser Ser Gly Ala Ser Leu Asp Leu Pro Gly Phe Arg Val Asn Leu Pro

1000 1005 1010aac aac act gtg gcg ttt tcc acc gca gcc gaa ctg gca cca tcc gca 3187Asn Asn Thr Val Ala Phe Ser Thr Ala Ala Glu Leu Ala Pro Ser Ala

1015 1020 1025gtg gca atc atg gaa gca gcc gcc atg gct gtc acc cca ggt tcc tcc 3235Val Ala Ile Met Glu Ala Ala Ala Met Ala Val Thr Pro Gly Ser Ser1030 1035 1040 1045gtc gac gca gtg gac gag cgc gac atg ctg cca cca agc ggc gaa atc 3283Val Asp Ala Val Asp Glu Arg Asp Met Leu Pro Pro Ser Gly Glu Ile

1050 1055 1060acc acc atc gtg act cgc tcc ttg ggc ggt ttg agc ctg tcc gta tac 3331Thr Thr Ile Val Thr Arg Ser Leu Gly Gly Leu Ser Leu Ser Val Tyr

1065 1070 1075aag att gag gga acc acc agc act ctt gtc gcc gaa ggt ttc gca gcc 3379Lys Ile Glu Gly Thr Thr Ser Thr Leu Val Ala Glu Gly Phe Ala Ala

1080 1085 1090aac cca gga ttc gcc gca gca tct tcc ttc gac ggt cca ggc tac gac 3427Asn Pro Gly Phe Ala Ala Ala Ser Ser Phe Asp Gly Pro Gly Tyr Asp

1095 1100 1105gga ttc aac acc gat tac agc gac cag cca gac cct cgc tcc gac ctg 3475Gly Phe Asn Thr Asp Tyr Ser Asp Gln Pro Asp Pro Arg Ser Asp Leu1110 1115 1120 1125cct ttg gac atc gaa gca gtc cgc tgg gac cca gcg acc gaa acc gtc 3523Pro Leu Asp Ile Glu Ala Val Arg Trp Asp Pro Ala Thr Glu Thr Val

1130 1135 1140gaa gag cgc atg cgc gcc atcgtc tcc gaa gca atg ggc tac gac gtg 3571Glu Glu Arg Met Arg Ala Ile Val Ser Glu Ala Met Gly Tyr Asp Val

1145 1150 1155gat gac ctc cca cgc gaa ctc cca ctg att gac ctc ggc ctc gac tcc 3619Asp Asp Leu Pro Arg Glu Leu Pro Leu Ile Asp Leu Gly Leu Asp Ser

1160 1165 1170ctc atg ggc atg cgc atc aaa aac cgc atc gaa aat gac ttc cag atc 3667Leu Met Gly Met Arg Ile Lys Asn Arg Ile Glu Asn Asp Phe Gln Ile

1175 1180 1185cca cca ctc cag gtc caa gcg ctc cgc gat gca tcc gtc gct gac gtg 3715Pro Pro Leu Gln Val Gln Ala Leu Arg Asp Ala Ser Val Ala Asp Val1190 1195 1200 1205gta atc atg gtg gaa aac atg gtc gct ggc cgc tcc tct gag acg ctt 3763Val Ile Met Val Glu Asn Met Val Ala Gly Arg Ser Ser Glu Thr Leu

1210 1215 1220gtc gac gcc acc ccg cag gtg cca gct gag gca gca ggg gag gct caa 3811Val Asp Ala Thr Pro Gln Val Pro Ala Glu Ala Ala Gly Glu Ala Gln

1225 1230 1235gct gct gag tct tct gct tcg ggc gag gac gtg cag ggc gtt ggc gtt 3859Ala Ala Glu Ser Ser Ala Ser Gly Glu Asp Val Gln Gly Val Gly Val

1240 1245 1250gca ccg cga gat gcg tcg gaa cgc atg gtc ttt ggt act tgg gca ggc 3907Ala Pro Arg Asp Ala Ser Glu Arg Met Val Phe Gly Thr Trp Ala Gly

1255 1260 1265ctg act ggc gct gcg gca gct ggc gtg acc agc aag ttg cca cag atc 3955Leu Thr Gly Ala Ala Ala Ala Gly Val Thr Ser Lys Leu Pro Gln Ile1270 1275 1280 1285gat gtc gat act gca acc gca att gcc gag cgc ctc acc gag cgt tcc 4003Asp Val Asp Thr Ala Thr Ala Ile Ala Glu Arg Leu Thr Glu Arg Ser

1290 1295 1300gga att gaa atc agc act gaa cag gtg ttg gct gca gaa acc ctc gaa 4051Gly Ile Glu Ile Ser Thr Glu Gln Val Leu Ala Ala Glu Thr Leu Glu

1305 1310 1315cca ctg tct gac ctg gtg cgt gaa ggc ctc gaa act gaa gtt cag ggc 4099Pro Leu Ser Asp Leu Val Arg Glu Gly Leu Glu Thr Glu Val Gln Gly

1320 1325 1330aac att cgt gtg ctg cgt gga cgt gca gaa ggc tcc acc aag cct gca 4147Asn Ile Arg Val Leu Arg Gly Arg Ala Glu Gly Ser Thr Lys Pro Ala

1335 1340 1345gtg ttc atg ttc cac cca gct ggc ggt tct tcc gtg gtc tac caa cca 4195Val Phe Met Phe His Pro Ala Gly Gly Ser Ser Val Val Tyr Gln Pro1350 1355 1360 1365cta atg cgt cgt ctg cct gaa gat gtc cct gtc tat ggc gtt gag cgt 4243Leu Met Arg Arg Leu Pro Glu Asp Val Pro Val Tyr Gly Val Glu Arg

1370 1375 1380ctg gaa ggc gat ctc gct gac cgc gcg gca gca tat gtt gat gac atc 4291Leu Glu Gly Asp Leu Ala Asp Arg Ala Ala Ala Tyr Val Asp Asp Ile

1385 1390 1395aag aag tac tcc gat ggc ttc cca gta gtt ttg ggt ggc tgg agc ttc 4339Lys Lys Tyr Ser Asp Gly Phe Pro Val Val Leu Gly Gly Trp Ser Phe

1400 1405 1410ggc ggt gcc gtt gcc ttc gag gtt gcc cac caa ctg gtt ggc tcc gat 4387Gly Gly Ala Val Ala Phe Glu Val Ala His Gln Leu Val Gly Ser Asp

1415 1420 1425gtt gag gta gct acc gtg gcg ttg ctg gat act gtg cag cct rca aac 4435Val Glu Val Ala Thr Val Ala Leu Leu Asp Thr Val Gln Pro Ser Asn1430 1435 1440 1445cca gca cca gat acc gct gag gaa act cgt gca cgc tgg act cgc tac 4483Pro Ala Pro Asp Thr Ala Glu Glu Thr Arg Ala Arg Trp Thr Arg Tyr

1450 1455 1460gcg gac ttc gcc aag aag acc tac ggc ctt gat ttc gag gta cct ttt 4531Ala Asp Phe Ala Lys Lys Thr Tyr Gly Leu Asp Phe Glu Val Pro Phe

1465 1470 1475gaa atc ttg gac acc atc ggt gaa gac gga atg ctg tcc atg atg acc 4579Glu Ile Leu Asp Thr Ile Gly Glu Asp Gly Met Leu Ser Met Met Thr

1480 1485 1490gac ttc ctg gcc aac acc gac gcc tcc gag cac gga ttg tcc gca ggt 4627Asp Phe Leu Ala Asn Thr Asp Ala Ser Glu His Gly Leu Ser Ala Gly

1495 1500 1505gtg ctt gaa cac cag cgc gct tct ttt gtg gac aac cgc atc ctg gct 4675Val Leu Glu His Gln Arg Ala Ser Phe Val Asp Asn Arg Ile Leu Ala1510 1515 1520 1525aaa ctt aat ttt gca gac tgg gcc aac gtt gaa gcc cct gtc atc ctg 4723Lys Leu Asn Phe Ala Asp Trp Ala Asn Val Glu Ala Pro Val Ile Leu

1530 1535 1540ttc cgc gcg gaa cgc atg cat gat gga gct atc gaa ctt gaa cca aac 4771Phe Arg Ala Glu Arg Met His Asp Gly Ala Ile Glu Leu Glu Pro Asn

1545 1550 1555tat gcc aag att gat caa gat gga gga tgg tcc gga att gtc aac gat 4819Tyr Ala Lys Ile Asp Gln Asp Gly Gly Trp Ser Gly Ile Val Asn Asp

1560 1565 1570ttg gaa att gtt cag ctg aat ggt gac cac ctg gca gtt gtc gat gaa 4867Leu Glu Ile Val Gln Leu Asn Gly Asp His Leu Ala Val Val Asp Glu

1575 1580 1585cca gaa atc ggc aca gtc gga gct cat ttg agt cgc cgc att gat gag 4915Pro Glu Ile Gly Thr Val Gly Ala His Leu Ser Arg Arg Ile Asp Glu1590 1595 1600 1605att tct cgg aag aat tagtaacgga gagctgacgg aag 4953Ile Ser Arg Lys Asn

1610<210>14<211>1610<212>PRT<2l3>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>14Met Glu Gln Ser Gln Ser Ser Asp Gln Lys Met Thr Val Glu Gln Val 151015 Arg Thr Trp Leu Arg Asp Trp Val Val Arg Thr Thr Gly Ile Pro Val

20 25 30Glu Glu Val Thr Asp Asp Lys Ala Met Glu Thr Phe Gly Leu Ser Ser

35 40 45Arg Asp Val Val Val Leu Ser Gly Glu Leu Glu Asn Leu Leu Asp Thr

50 55 60Ser Leu Asp Ala Thr Ile Ala Tyr Glu Tyr Pro Thr Ile Arg Ser Leu 65 70 75 80Ala Gln Arg Leu Val Glu Gly Glu Pro Arg Arg Ala Hls Thr Gln Arg

85 90 95Glu Leu Asn Phe Ser Ala Val Ser Asp Ser Pro Gly Ser His Asp Ile

100 105 110Ala Val Val Gly Met Ala Ala Arg Tyr Pro Gly Ala Glu Ser Leu Glu

115 120 125Asp Met Trp Lys Leu Leu Val Glu Gly Arg Asp Gly Ile Ser Asp Leu

130 135 140Pro Ile Gly Arg Trp Ser Glu Tyr Ala Gly Asp Glu Val Met Ser Arg145 150 155 160Lys Met Glu Glu Phe Ser Thr Ile Gly Gly Tyr Leu Ser Asp Ile Ser

165 170 175Ser Phe Asp Ala Glu Phe Phe Gly Leu Ser Pro Leu Glu Ala Ala Asn

180 185 190Met Asp Pro Gln Gln Arg Ile Leu Leu Glu Leu Thr Trp Glu Ala Leu

195 200 205Glu Tyr Ala Arg Ile Ala Pro Asn Thr Leu Arg Gly Glu Ala Val Gly

210 215 220Val Phe Ile Gly Ser Ser Asn Asn Asp Tyr Gly Met Met Ile Ala Ala225 230 235 240Asp Pro Ala Glu Ala His Pro Tyr Ala Leu Thr Gly Thr Ser Ser Ala

245 250 255Ile Val Ala Asn Arg Ile Asn Tyr Ala Phe Asp Phe Arg Gly Pro Ser

260 265 270Val Asn Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Val His Gln

275 280 285Ala Val Arg Ala Leu Arg Asn Gly Glu Ala Asp His Ala Ile Ala Gly

290 295 300Gly Val Asn Ile Leu Ala Ser Pro Phe Val Thr Thr Ala Phe Ala Glu305 310 315 320Leu Gly Val Ile Ser Pro Thr Gly Lys Ile His Ala Phe Ser Asp Asp

325 330 335Ala Asp Gly Phe Val Arg Ser Asp Gly Ala Gly Val Val Val Leu Lys

340 345 350Arg Val Asp Asp Ala Ile Arg Asp Gly Asp Lys Ile Ile Gly Val Ile

355 360 365Lys Gly Ser Ala Val Asn Ser Asp Gly His Ser Asn Gly Leu Thr Ala

370 375 380Pro Asn Pro Asp Ala Gln Val Asp Val Leu Gln Arg Ala Tyr Val Asp385 390 395 400Ala Gln Val Asp Pro Thr Thr Val Asp Tyr Val Glu Ala His Gly Thr

405 410 415Gly Thr Ile Leu Gly Asp Pro Ile Glu Ala Thr Ala Leu Gly Ala Val

420 425 430Leu Gly Tyr Gly Arg Asp Ala Ser Thr Pro Thr Leu Leu Gly Ser Ala

435 440 445Lys Ser Asn Phe Gly His Thr Glu Ser Ala Ala Gly Ile Ala Gly Val

450 455 460Ile Lys Val Leu Leu Ala Leu Gln Asn Lys Thr Leu Pro Pro Thr Val465 470 475 480Asn Phe Ala Gly Pro Asn Arg Tyr Ile Asp Phe Asp Ala Glu Arg Leu

485 490 495Glu Val Val Glu Asp Pro Arg Glu Trp Pro Glu Tyr Asn Gly His Ala

500 505 510Val Ala Gly Val Ser Ala Phe Gly Phe Gly Gly Thr Asn Ala His Val

515 520 525Val Ile Ser Glu Tyr Asn Ala Glu Asp Tyr Glu Thr Arg Ala Pro Lys

530 535 540Glu Ala Leu Leu Pro Asp Gln Gln Val Ala Leu Pro Val Ser Gly His545 550 555 560Leu Pro Ser Arg Arg Arg Gln Ala Ala Ala Asp Leu Ala Asp Phe Leu

565 570 575Glu Gly Arg Lys Asp Cys Asp Leu Thr Pro Val Ala Arg Ala Leu Ala

580 585 590Gly Arg Asn His Gly Arg Ser Arg Ala Val Val Leu Ala Ser Thr Ile

595 600 605Glu Glu Ala Val Lys Arg Leu Arg Gln Val Ala Glu Gly Lys Val Ser

610 615 620Val Gly Ile Ser Ala Ala Asp Ser Pro Ala Ala Asn Gly Pro Val Phe625 630 635 640Val Tyr Ser Gly Phe Gly Ser Gln His Arg Leu Met Ile Lys Glu Leu

645 650 655Cys Ser Ile Ser Pro Gln Phe Arg Glu Arg Ile Glu Glu Leu Asp Glu

660 665 670Met Val Lys Phe Glu Ser Gly Trp Ser Ile Met Lys Leu Val Leu Asp

675 680 685Asp Glu Gln Thr Tyr Asp Thr Glu Thr Ala Gln Val Val Ile Thr Ala

690 695 700Ile Gln Ile Ala Leu Thr Asp Leu Leu Ala Ser Phe Gly Val Lys Pro705 710 715 720Ala Ala Val Met Gly Met Ser Met Gly Glu Ile Ala Ala Ala Tyr Ala

725 730 735Ala Gly Gly Leu Ser Asp Arg Asp Thr Met Leu Ile Ala Ser His Arg

740 745 750Ser Arg Leu Met Gly Glu Gly Glu Lys Ser Leu Ala Glu Asp Gln Leu

755 760 765Gly Ala Met Ala Val Val Glu Phe Ala Ala Ala Asp Leu Asp Lys Phe

770 775 780Ile Glu Glu Asn Pro Glu Tyr Lys Gly Ile Glu Pro Ala Val Tyr Ala785 790 795 800Gly Pro Gly Met Thr Thr Val Gly Gly Pro Arg Asp Ala Val Val Gln

805 810 815Phe Val Glu Lys Leu Glu Ser Glu Asp Lys Phe Ala Arg Leu Leu Asn

820 825 830Val Lys Gly Ala Gly His Thr Ser Ala Val Glu Pro Leu Leu Gly Glu

835 840 845Leu Ala Gly Glu Ile Ala Gly Ile Glu Pro Leu Pro Leu Gln Ile Pro

850 855 860Leu Phe Ser Ser Val Asp Gln Gly Val Thr Tyr Pro Val Gly Ala Val865 870875 880Val His Asp Ala Asp Tyr Met Leu Arg Cys Thr Arg Gln Ser Val Tyr

885 890 895Phe Gln Asp Ser Thr Glu Ala Ala Phe Ala Ala Gly His Asn Thr Leu

900 905 910Val Glu Ile Ser Pro Asn Pro Val Ala Leu Met Gly Met Met Asn Thr

915 920 925Ala Phe Thr Val Gly Lys Pro Asp Ala Gln Leu Leu Phe Ser Leu Lys

930 935 940Arg Lys Val Pro Glu Ala Glu Ser Leu Arg Asp Leu Leu Ala Lys Leu945 950 955 960Tyr Val Asn Gly Ala Asn Val Asp Phe Ser Ala Leu Tyr Gly Glu Gly

965 970 975Glu Thr Ile Asp Pro Pro His Ile Thr Trp Lys His Gln Arg Phe Trp

980 985 990Thr Ser Ala Arg Pro Ser Ser Gly Ala Ser Leu Asp Leu Pro Gly Phe

995 1000 1005Arg Val Asn Leu Pro Asn Asn Thr Val Ala Phe Ser Thr Ala Ala Glu

1010 1015 1020Leu Ala Pro Ser Ala Val Ala Ile Met Glu Ala Ala Ala Met Ala Val1025 1030 1035 1040Thr Pro Gly Ser Ser Val Asp Ala Val Asp Glu Arg Asp Met Leu Pro

1045 1050 1055Pro Ser Gly Glu Ile Thr Thr Ile Val Thr Arg Ser Leu Gly Gly Leu

1060 1065 1070Ser Leu Ser Val Tyr Lys Ile Glu Gly Thr Thr Ser Thr Leu Val Ala

1075 1080 1085Glu Gly Phe Ala Ala Asn Pro Gly Phe Ala Ala Ala Ser Ser Phe Asp

1090 10951100Gly Pro Gly Tyr Asp Gly Phe Asn Thr Asp Tyr Ser Asp Gln Pro Asp1105 1110 1115 1120Pro Arg Ser Asp Leu Pro Leu Asp Ile Glu Ala Val Arg Trp Asp Pro

1125 1130 1135Ala Thr Glu Thr Val Glu Glu Arg Met Arg Ala Ile Val Ser Glu Ala

1140 1145 1150Met Gly Tyr Asp Val Asp Asp Leu Pro Arg Glu Leu Pro Leu Ile Asp

1155 1160 1165Leu Gly Leu Asp Ser Leu Met Gly Met Arg Ile Lys Asn Arg Ile Glu

1170 1175 1180Asn Asp Phe Gln Ile Pro Pro Leu Gln Val Gln Ala Leu Arg Asp Ala1185 1190 1195 1200Ser Val Ala Asp Val Val Ile Met Val Glu Asn Met Val Ala Gly Arg

1205 1210 1215Ser Ser Glu Thr Leu Val Asp Ala Thr Pro Gln Val Pro Ala Glu Ala

1220 1225 1230Ala Gly Glu Ala Gln Ala Ala Glu Ser Ser Ala Ser Gly Glu Asp Val

1235 1240 1245Gln Gly Val Gly Val Ala Pro Arg Asp Ala Ser Glu Arg Met Val Phe

1250 1255 1260Gly Thr Trp Ala Gly Leu Thr Gly Ala Ala Ala Ala Gly Val Thr Ser1265 1270 1275 1280Lys Leu Pro Gln Ile Asp Val Asp Thr Ala Thr Ala Ile Ala Glu Arg

1285 1290 1295Leu Thr Glu Arg Ser Gly Ile Glu Ile Ser Thr Glu Gln Val Leu Ala

1300 1305 1310Ala Glu Thr Leu Glu Pro Leu Ser Asp Leu Val Arg Glu Gly Leu Glu

13151320 1325Thr Glu Val Gln Gly Asn Ile Arg Val Leu Arg Gly Arg Ala Glu Gly

1330 1335 1340Ser Thr Lys Pro Ala Val Phe Met Phe His Pro Ala Gly Gly Ser Ser1345 1350 1355 1360Val Val Tyr Gln Pro Leu Met Arg Arg Leu Pro Glu Asp Val Pro Val

1365 1370 1375Tyr Gly Val Glu Arg Leu Glu Gly Asp Leu Ala Asp Arg Ala Ala Ala

1380 1385 1390Tyr Val Asp Asp Ile Lys Lys Tyr Ser Asp Gly Phe Pro Val Val Leu

1395 1400 1405Gly Gly Trp Ser Phe Gly Gly Ala Val Ala Phe Glu Val Ala His Gln

1410 1415 1420Leu Val Gly Ser Asp Val Glu Val Ala Thr Val Ala Leu Leu Asp Thr1425 1430 1435 1440Val Gln Pro Ser Asn Pro Ala Pro Asp Thr Ala Glu Glu Thr Arg Ala

1445 1450 1455Arg Trp Thr Arg Tyr Ala Asp Phe Ala Lys Lys Thr Tyr Gly Leu Asp

1460 1465 1470Phe Glu Val Pro Phe Glu Ile Leu Asp Thr Ile Gly Glu Asp Gly Met

1475 1480 1485Leu Ser Met Met Thr Asp Phe Leu Ala Asn Thr Asp Ala Ser Glu His

1490 1495 1500Gly Leu Ser Ala Gly Val Leu Glu His Gln Arg Ala Ser Phe Val Asp1505 1510 1515 1520Asn Arg Ile Leu Ala Lys Leu Asn Phe Ala Asp Trp Ala Asn Val Glu

1525 1530 1535Ala Pro Val Ile Leu Phe Arg Ala Glu Arg Met His Asp Gly Ala Ile

15401545 1550Glu Leu Glu Pro Asn Tyr Ala Lys Ile Asp Gln Asp Gly Gly Trp Ser

1555 1560 1565Gly Ile Val Asn Asp Leu Glu Ile Val Gln Leu Asn Gly Asp His Leu

1570 1575 1580Ala Val Val Asp Glu Pro Glu Ile Gly Thr Val Gly Ala His Leu Ser1585 1590 1595 1600Arg Arg Ile Asp Glu Ile Ser Arg Lys Asn

16051610<210>15<211>540<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><22l>CDS<222>(101) } (517)<223>RXA01138<400>15cttattcaag tttttggaaa gataattaac tatgacttta aaaacagtaa acggaacgca 60gctgcgagac actgtcggat cgttcccttc aggtgtcacg gtg gtc acc act acc 115

Val Val Thr Thr Thr

1 5gat ggg gaa gtg gac cac ggg ttg act gtg agt gcg ttc gtg tcc ttg 163Asp Gly Glu Val Asp His Gly Leu Thr Val Ser Ala Phe Val Ser Leu

10 15 20tcg ttg gag cct gcc atg gtg ttg gtg agt atc gat aag aaa tca agc 211Ser Leu Glu Pro Ala Met Val Leu Val Ser Ile Asp Lys Lys Ser Ser

25 30 35gtt gtg ccg ttt ttg gag cag ggt tca cca gtt gct gtg tct gtg tta 259Val Val Pro Phe Leu Glu Gln Gly Ser Pro Val Ala Val Ser Val Leu

40 45 50tcg gaa gag cag agc gat ttg gcc atc aca ttt ggc cgt cat ctg gaa 307Ser Glu Glu Gln Ser Asp Leu Ala Ile Thr Phe Gly Arg His Leu Glu

55 60 65aac aaa ttc gac ggc gtt tcc att aag cgt tca aca aac agg gca gcg 355Asn Lys Phe Asp Gly Val SerIle Lys Arg Ser Thr Asn Arg Ala Ala 70 75 80 85gtc ttg gaa ggt gcg tca gca tgg ttg agt ggc gct gtg gtg gat aaa 403Val Leu Glu Gly Ala Ser Ala Trp Leu Ser Gly Ala Val Val Asp Lys

90 95 100tac cca ggt gga gat cac ttt att atc acc att gcc gtg gaa gag tgt 451Tyr Pro Gly Gly Asp His Phe Ile Ile Thr Ile Ala Val Glu Glu Cys

105 110 115gct cac gac gag gag caa aag cca ctt ctt tac cac cgt ggc agg ctt 499Ala His Asp Glu Glu Gln Lys Pro Leu Leu Tyr His Arg Gly Arg Leu

120 125 130ttt cag tgg caa gaa gat taattctcca ccccttcatt ttc 540Phe Gln Trp Gln Glu Asp

135<210>16<211>139<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>16Val Val Thr Thr Thr Asp Gly Glu Val Asp His Gly Leu Thr Val Ser 151015 Ala Phe Val Ser Leu Ser Leu Glu Pro Ala Met Val Leu Val Ser Ile

20 25 30Asp Lys Lys Ser Ser Val Val Pro Phe Leu Glu Gln Gly Ser Pro Val

35 40 45Ala Val Ser Val Leu Ser Glu Glu Gln Ser Asp Leu Ala Ile Thr Phe

50 55 60Gly Arg His Leu Glu Asn Lys Phe Asp Gly Val Ser Ile Lys Arg Ser 65 70 75 80Thr Asn Arg Ala Ala Val Leu Glu Gly Ala Ser Ala Trp Leu Ser Gly

85 90 95Ala Val Val Asp Lys Tyr Pro Gly Gly Asp His Phe Ile Ile Thr Ile

100 105 110Ala Val Glu Glu Cys Ala His Asp Glu Glu Gln Lys Pro Leu Leu Tyr

115 120 125His Arg Gly Arg Leu Phe Gln Trp Gln Glu Asp

130135<210>17<211>756<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (733)<223>RXA01980<400>17aggatcgtac caaataaggc aataaactct ttttactttt cctcaacttc ctgaaaagtc 60gccgccctag aattcactaa gtttccgata tctttaaccc atg cag atc att gat 115

Met Gln Ile Ile Asp

1 5ctc tct cat gcg ttc gcg ccc gga caa ccc cac tac cct ggg gat cca 163Leu Ser His Ala Phe Ala Pro Gly Gln Pro His Tyr Pro Gly Asp Pro

10 15 20gat caa gaa att aag acg gtc tcc acg att gaa aac gat ggc ttt tta 211Asp Gln Glu Ile Lys Thr Val Ser Thr Ile Glu Asn Asp Gly Phe Leu

25 30 35atg cat caa tac aga ctt gtt ggt ccc tgg gga acg cat gta gat gca 259Met His Gln Tyr Arg Leu Val Gly Pro Trp Gly Thr His Val Asp Ala

40 45 50cct gca cat ttc gat cca caa ggt cgg acg ctt gat cag atc cct gtg 307Pro Ala His Phe Asp Pro Gln Gly Arg Thr Leu Asp Gln Ile Pro Val

55 60 65gag gaa acg cat tta ccc ctt tat tgc ctg agg ttt tct cgc ccc gat 355Glu Glu Thr His Leu Pro Leu Tyr Cys Leu Arg Phe Ser Arg Pro Asp 70 75 80 85cta tgt act gct gct gat ata gaa gcg ttt gaa cat aca cae ggg aaa 403Leu Cys Thr Ala Ala Asp Ile Glu Ala Phe Glu His Thr His Gly Lys

90 95 100atc gaa cca gga tcc ttc gtc gca ctc cac act gga tgg gaa tgg ggt 451IleGlu Pro Gly Ser Phe Val Ala Leu His Thr Gly Trp Glu Trp Gly

105 110 115aaa caa ggg atc gca ccc ggc tgg tct atc gag gct tta gaa atc ctc 499Lys Gln Gly Ile Ala Pro Gly Trp Ser Ile Glu Ala Leu Glu Ile Leu

120 125 130cat gcc cgt gga gtc att gcc att ggc cac gat ctt ccc gat aca gat 547His Ala Arg Gly Val Ile Ala Ile Gly His Asp Leu Pro Asp Thr Asp

135 140 145cct tca ctg gag gca cag cgc tgg tgg ctg tgc cgt gac cat tgg cag 595Pro Ser Leu Glu Ala Gln Arg Trp Trp Leu Cys Arg Asp His Trp Gln150 155 160 165att gaa aac ctc acc aat ttg gac aag gtt cct gca acg ggt gcg atg 643Ile Glu Asn Leu Thr Asn Leu Asp Lys Val Pro Ala Thr Gly Ala Met

170 175 180att gct tgt cct tgg cca gtt cca aaa gat ggt gct agt ttc cca gtg 691Ile Ala Cys Pro Trp Pro Val Pro Lys Asp Gly Ala Ser Phe Pro Val

185 190 195cgt cca att gct ctc gtc cca gag cac cta tcc cct act cgc 733Arg Pro Ile Ala Leu Val Pro Glu His Leu Ser Pro Thr Arg

200205210 taaagcgaac ggcagcacct tct 756<210>18<211>211<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>18Met Gln Ile Ile Asp Leu Ser His Ala Phe Ala Pro Gly Gln Pro His 151015 Tyr Pro Gly Asp Pro Asp Gln Glu Ile Lys Thr Val Ser Thr Ile Glu

20 25 30Asn Asp Gly Phe Leu Met His Gln Tyr Arg Leu Val Gly Pro Trp Gly

35 40 45Thr His Val Asp Ala Pro Ala His Phe Asp Pro Gln Gly Arg Thr Leu

50 5560Asp Gln Ile Pro Val Glu Glu Thr His Leu Pro Leu Tyr Cys Leu Arg 65 70 75 80Phe Ser Arg Pro Asp Leu Cys Thr Ala Ala Asp Ile Glu Ala Phe Glu

85 90 95His Thr His Gly Lys Ile Glu Pro Gly Ser Phe Val Ala Leu His Thr

100 105 110Gly Trp Glu Trp Gly Lys Gln Gly Ile Ala Pro Gly Trp Ser Ile Glu

115 120 125Ala Leu Glu Ile Leu His Ala Arg Gly Val Ile Ala Ile Gly His Asp

130 135 140Leu Pro Asp Thr Asp Pro Ser Leu Glu Ala Gln Arg Trp Trp Leu Cys145 150 155 160Arg Asp His Trp Gln Ile Glu Asn Leu Thr Asn Leu Asp Lys Val Pro

165 170 175Ala Thr Gly Ala Met Ile Ala Cys Pro Trp Pro Val Pro Lys Asp Gly

180 185 190Ala Ser Phe Pro Val Arg Pro Ile Ala Leu Val Pro Glu His Leu Ser

195 200 205Pro Thr Arg

210<210>19<211>1830<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1807)<223>RXN01007<400>19tctgaaccaa tataccgatc agtctaaaag tgtgttaagt tctggaacat aaattagctg 60acacgtaaag taacttaaag attcactgga ggtaagccta gtg ttt aaa aag cac 115

Val Phe Lys Lys His

1 5aga cac ggt ctc ggc tcc ccc gaa acc aaa cca cgc tca ata acc cgc 163Arg His Gly Leu Gly Ser Pro Glu Thr Lys Pro Arg Ser Ile Thr Arg

10 15 20cgg ttt ttc acc gcg gcc gcc gct acg ctg gca gga ttg gca gtc ctg 211Arg Phe Phe Thr Ala Ala Ala Ala Thr Leu Ala Gly Leu Ala Val Leu

25 30 35tcc ggc tgc aca gca caa ccc tca caa gca gaa gac aac acg ctc act 259Ser Gly Cys Thr Ala Gln Pro Ser Gln Ala Glu Asp Asn Thr Leu Thr

40 45 50tac tta gag cca cag ttc ttc cgc acc ctg tac cca cca tca gcg ggc 307Tyr Leu Glu Pro Gln Phe Phe Arg Thr Leu Tyr Pro Pro Ser Ala Gly

55 60 65ttt tac ccc aac ggc agt gtg gtg aac aac att gca gac cgc ttg ctc 355Phe Tyr Pro Asn Gly Ser Val Val Asn Asn Ile Ala Asp Arg Leu Leu 70 75 80 85tac cag gat cct gaa acc ttg gaa ctc aag ccg tgg atc gcc acc gaa 403Tyr Gln Asp Pro Glu Thr Leu Glu Leu Lys Pro Trp Ile Ala Thr Glu

90 95 100ctc cca gaa gta aac gaa gac gcc acg gaa ttt acc ttc aac atc cgc 451Leu Pro Glu Val Asn Glu Asp Ala Thr Glu Phe Thr Phe Asn Ile Arg

105 110 115acc gat gtc acc tac tcc gat ggc acc ccg ctg acg gct gaa aac gtg 499Thr Asp Val Thr Tyr Ser Asp Gly Thr Pro Leu Thr Ala Glu Asn Val

120 125 130gtg aaa aac ttc gat ctc tat ggc ctc ggc gat caa gat cga cgc ctc 547Val Lys Asn Phe Asp Leu Tyr Gly Leu Gly Asp Gln Asp Arg Arg Leu

135 140 145acc atc tct gag cag atc acc aac tac gac cac ggc gaa gta gta gat 595Thr Ile Ser Glu Gln Ile Thr Asn Tyr Asp His Gly Glu Val Val Asp150 155 160 165gag gac acc gtc cga ttc cac ttc tct gag cct gca cct ggt ttt gct 643Glu Asp Thr Val Arg Phe His Phe Ser Glu Pro Ala Pro Gly Phe Ala

170 175 180cag gcc acc agc tcc ttc aac gct ggc ctt tat gcc gat tcc acc ttg 691Gln Ala Thr Ser Ser Phe Asn Ala Gly Leu Tyr Ala Asp Ser Thr Leu

185 190 195gag ttc gcc aat gag gat ttc gcg cca ggc aac gcc caa aac gtc atc 739Glu Phe Ala Asn Glu Asp Phe Ala Pro Gly Asn Ala Gln Asn Val Ile

200 205 210ggc tcc ggt cct ttc gtg atc acc gat gaa acc cta ggc acc aac ctc 787Gly Ser Gly Pro Phe Val Ile Thr Asp Glu Thr Leu Gly Thr Asn Leu

215 220 225acc ttg act gcg cgt gag gat tac gat tgg gca cca cca tca cgc gaa 835Thr Leu Thr Ala Arg Glu Asp Tyr Asp Trp Ala Pro Pro Ser Arg Glu230 235 240 245cat caa ggt cgc gcg aag ctt gac gcc gtc aat tat gtc ctc gcg ggt 883His Gln Gly Arg Ala Lys Leu Asp Ala Val Asn Tyr Val Leu Ala Gly

250 255 260gaa gaa tcc gtc cgc atc gga gcc atc gtt gct ggc caa ggt gat atc 931Glu Glu Ser Val Arg Ile Gly Ala Ile Val Ala Gly Gln Gly Asp Ile

265 270 275gcc cgc cag atc gaa gcg cca gtg gag gca cac ctg aag gat gca ggc 979Ala Arg Gln Ile Glu Ala Pro Val Glu Ala His Leu Lys Asp Ala Gly

280 285 290atc ccg atc atc tcc gca gcc acc aac ggt gtg aac aac agc ttc aac 1027Ile Pro Ile Ile Ser Ala Ala Thr Asn Gly Val Asn Asn Ser Phe Asn

295 300 305ttc cgc ttc aaa aac gag ctg ctc tca gac atc cgt gtt cgc caa gct 1075Phe Arg Phe Lys Asn Glu Leu Leu Set Asp Ile Arg Val Arg Gln Ala310315 320 325ctg atc cac gcg atc gac cgc gaa aag atc atg cgt gtg ctg ttt agt 1123Leu Ile His Ala Ile Asp Arg Glu Lys Ile Met Arg Val Leu Phe Ser

330 335 340gat tcc tat ccg ctg gca act tct gtg ctt gcg caa aat gca ctg ggc 1171Asp Ser Tyr Pro Leu Ala Thr Ser Val Leu Ala Gln Asn Ala Leu Gly

345 350 355tac aaa gaa caa gta gat gcc tat gtc tac gac cta gac aaa gca aca 1219Tyr Lys Glu Gln Val Asp Ala Tyr Val Tyr Asp Leu Asp Lys Ala Thr

360 365 370gct ctg ctt gac gaa gcc ggc tgg acc ctt gat agc gac ggc atg cgt 1267Ala Leu Leu Asp Glu Ala Gly Trp Thr Leu Asp Ser Asp Gly Met Arg

375 380 385cgc aag gac ggt gaa ctt cta gag ctc acc ttc aac gaa gcc ctc cca 1315Arg Lys Asp Gly Glu Leu Leu Glu Leu Thr Phe Asn Glu Ala Leu Pro390 395 400 405cag cct cgt tca cgc gaa gtt gtc acc atg gtc caa gaa cag ctc ggt 1363Gln Pro Arg Ser Arg Glu Val Val Thr Met Val Gln Glu Gln Leu Gly

410 415 420gat ctg ggc atc aag gtc aac ctc aac cca ggt gac caa gca gcc cag 1411Asp Leu Gly Ile Lys Val Asn Leu Asn Pro Gly Asp Gln Ala Ala Gln

425 430 435gac gct gac tcc aag gat ctc aac aag atc cag gtt cgc cac acc atg 1459Asp Ala Asp Ser Lys Asp Leu Asn Lys Ile Gln Val Arg His Thr Met

440 445 450gtg ggt cgc gca gac tat gac gtg ctg aaa tcc cag ctg tac tcc acc 1507Val Gly Arg Ala Asp Tyr Asp Val Leu Lys Ser Gln Leu Tyr Ser Thr

455 460 465aac cgc aac gag ctg ttg aac atg accgtg gaa ggg gag acc gcc gat 1555Asn Arg Asn Glu Leu Leu Asn Met Thr Val Glu Gly Glu Thr Ala Asp470 475 480 485att ggc gat cct cat ttg gag gaa ctc ctc atg gct att gca tcc agc 1603Ile Gly Asp Pro His Leu Glu Glu Leu Leu Met Ala Ile Ala Ser Ser

490 495 500cca cgc gaa gag gac cgt gca gca gca tct gcc gca gca cag gat tac 1651Pro Arg Glu Glu Asp Arg Ala Ala Ala Ser Ala Ala Ala Gln Asp Tyr

505 510 515atc acc gag cag gca tat gtt ctt cca ctg ttt gaa gag cca gtt gtc 1699Ile Thr Glu Gln Ala Tyr Val Leu Pro Leu Phe Glu Glu Pro Val Val

520 525 530tac ggc gtg cag cct tac gtg aag ggc ttt agc ccc gaa gtg atc ggc 1747Tyr Gly Val Gln Pro Tyr Val Lys Gly Phe Ser Pro Glu Val Ile Gly

535540545 cgc ccc agc ttc tat gag acc tac att gac cat tcc agc gac cat tcc 1795Arg Pro Ser Phe Tyr Glu Thr Tyr Ile Asp His Ser Ser Asp His Ser 550555560565 agt gag gag gac taaatgacta cctcgcagat tct 1830Ser Glu Glu Asp<210>20<211>569<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>20Val Phe Lys Lys His Arg His Gly Leu Gly Ser Pro Glu Thr Lys Pro 151015 Arg Ser Ile Thr Arg Arg Phe Phe Thr Ala Ala Ala Ala Thr Leu Ala

20 25 30Gly Leu Ala Val Leu Ser Gly Cys Thr Ala Gln Pro Ser Gln Ala Glu

35 40 45Asp Asn Thr Leu Thr Tyr Leu Glu Pro Gln Phe Phe Arg Thr Leu Tyr

50 55 60Pro Pro Ser Ala Gly Phe Tyr Pro Asn Gly Ser Val Val Asn Asn Ile 65 70 75 80Ala Asp Arg Leu Leu Tyr Gln Asp Pro Glu Thr Leu Glu Leu Lys Pro

85 90 95Trp Ile Ala Thr Glu Leu Pro Glu Val Asn Glu Asp Ala Thr Glu Phe

100 105 110Thr Phe Asn Ile Arg Thr Asp Val Thr Tyr Ser Asp Gly Thr Pro Leu

115 120 125Thr Ala Glu Asn Val Val Lys Asn Phe Asp Leu Tyr Gly Leu Gly Asp

130 135 140Gln Asp Arg Arg Leu Thr Ile Ser Glu Gln Ile Thr Asn Tyr Asp His145 150 155 160Gly Glu Val Val Asp Glu Asp Thr Val Arg Phe His Phe Ser Glu Pro

165 170 175Ala Pro Gly Phe Ala Gln Ala Thr Ser Ser Phe Asn Ala Gly Leu Tyr

180 185 190Ala Asp Ser Thr Leu Glu Phe Ala Asn Glu Asp Phe Ala Pro Gly Asn

195 200 205Ala Gln Asn Val Ile Gly Ser Gly Pro Phe Val Ile Thr Asp Glu Thr

210 215 220Leu Gly Thr Asn Leu Thr Leu Thr Ala Arg Glu Asp Tyr Asp Trp Ala225 230 235 240Pro Pro Ser Arg Glu His Gln Gly Arg Ala Lys Leu Asp Ala Val Asn

245 250 255Tyr Val Leu Ala Gly Glu Glu Ser Val Arg Ile Gly Ala Ile Val Ala

260 265 270Gly Gln Gly Asp Ile Ala Arg Gln Ile Glu Ala Pro Val Glu Ala His

275 280 285Leu Lys Asp Ala Gly Ile Pro Ile Ile Ser Ala Ala Thr Asn Gly Val

290 295 300Asn Asn Ser Phe Asn Phe Arg Phe Lys Asn Glu Leu Leu Ser Asp Ile305 310 315 320Arg Val Arg Gln Ala Leu Ile His Ala Ile Asp Arg Glu Lys Ile Met

325 330 335Arg Val Leu Phe Ser Asp Ser Tyr Pro Leu Ala Thr Ser Val Leu Ala

340 345 350Gln Asn Ala Leu Gly Tyr Lys Glu Gln Val Asp Ala Tyr Val Tyr Asp

355 360 365Leu Asp Lys Ala Thr Ala Leu Leu Asp Glu Ala Gly Trp Thr Leu Asp

370 375 380Ser Asp Gly Met Arg Arg Lys Asp Gly Glu Leu Leu Glu Leu Thr Phe385 390 395 400Asn Glu Ala Leu Pro Gln Pro Arg Ser Arg Glu Val Val Thr Met Val

405 410 415Gln Glu Gln Leu Gly Asp Leu Gly Ile Lys Val Asn Leu Asn Pro Gly

420 425 430Asp Gln Ala Ala Gln Asp Ala Asp Ser Lys Asp Leu Asn Lys Ile Gln

435 440 445Val Arg His Thr Met Val Gly Arg Ala Asp Tyr Asp Val Leu Lys Ser

450 455 460Gln Leu Tyr Ser Thr Asn Arg Asn Glu Leu Leu Asn Met Thr Val Glu465 470 475 480Gly Glu Thr Ala Asp Ile Gly Asp Pro His Leu Glu Glu Leu Leu Met

485 490 495Ala Ile Ala Ser Ser Pro Arg Glu Glu Asp Arg Ala Ala Ala Ser Ala

500 505 510Ala Ala Gln Asp Tyr Ile Thr Glu Gln Ala Tyr Val Leu Pro Leu Phe

515 520 525Glu Glu Pro Val Val Tyr Gly Val Gln Pro Tyr Val Lys Gly Phe Ser

530 535 540Pro Glu Val Ile Gly Arg Pro Ser Phe Tyr Glu Thr Tyr Ile Asp His545 550 555 560Ser Ser Asp His Ser Ser Glu Glu Asp

565<210>21<211>858<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (835)<223>RXN00784<400>21gtcacatcag ttatcgcgcg gaatagttag cgggcgcatg tggttgggat atatgaataa 60atctattcca actacgcgta aaacgaggac gtttaaagct atg tct att gaa ttc 115

Met Ser Ile Glu Phe

1 5tcc gca cca gca aaa atg aaa atc gaa gtg tgg agc gac atc atg tgc 163Ser Ala Pro Ala Lys Met Lys Ile Glu Val Trp Ser Asp Ile Met Cys

10 15 20ccc ttc tgc tac atc ggc aaa aag cgc ctc gac gac gcc cta agt acc 211Pro Phe Cys Tyr Ile Gly Lys Lys Arg Leu Asp Asp Ala Leu Ser Thr

25 30 35ttt gac cag gcc gga cgc atc gaa gtg gaa tac aag agc ttc gaa ctc 259Phe Asp Gln Ala Gly Arg Ile Glu Val Glu Tyr Lys Ser Phe Glu Leu

40 45 50atg cca ggc cta gaa acc cac cca ctg cgt tcc gac gtt gaa tac ctc 307Met Pro Gly Leu Glu Thr His Pro Leu Arg Ser Asp Val Glu Tyr Leu

55 60 65gcc gac gcc aag ggc atg agc ctc gag cag gcc cgc caa atg aac ggc 355Ala Asp Ala Lys Gly Met Ser Leu Glu Gln Ala Arg Gln Met Asn Gly 70 75 80 85caa gtc caa gca atg gca caa gcc acc gga ctt gaa atg aat cct gac 403Gln Val Gln Ala Met Ala Gln Ala Thr Gly Leu Glu Met Asn Pro Asp

90 95 100gaa acc atc gcg gcc aac acc atc aac gcg cac cgc ctt acc cac ttc 451Glu Thr Ile Ala Ala Asn Thr Ile Asn Ala His Arg Leu Thr His Phe

105 110 115gcg aaa gcc cac ggc aag caa caa gaa gtg gcg cag gaa ctc ttc aag 499Ala Lys Ala His Gly Lys Gln Gln Glu Val Ala Gln Glu Leu Phe Lys

120 125 130gct cac ttc gta gac ggc aag aac gtt gat gac ctc gat gtg ctg gtc 547Ala His Phe Val Asp Gly Lys Asn Val Asp Asp Leu Asp Val Leu Val

135 140 145tcc att gct gca gag gtt ggt ctc gat gcc agt gca gcc cgc gaa gct 595Ser Ile Ala Ala Glu Val Gly Leu Asp Ala Ser Ala Ala Arg Glu Ala150 155 160 165ctc gaa tcc gac gtg tac acc aac gaa gtc caa caa gac gtc cac gaa 643Leu Glu Ser Asp Val Tyr Thr Asn Glu Val Gln Gln Asp Val His Glu

170 175 180gcc cgc caa ctc ggc gtc caa ggt gtg ccc ttc ttt gta ttc gac cgc 691Ala Arg Gln Leu Gly Val Gln Gly Val Pro Phe Phe Val Phe Asp Arg

185 190 195aaa tac gcc atc aac ggc gcc caa caa gaa gaa gta ttc acc ggc acc 739Lys Tyr Ala Ile Asn Gly Ala Gln Gln Glu Glu Val Phe Thr Gly Thr

200 205 210gta gaa aaa gcc ttc gaa gag tgg gca gcc gaa aac cca gtc agc cca 787Val Glu Lys Ala Phe Glu Glu Trp Ala Ala Glu Asn Pro Val Ser Pro

215220225 ttt gag gtc att gac ggc caa agc tgc tcc gtc gac ggc acc tgc aac 835Phe Glu Val Ile Asp Gly Gln Ser Cys Ser Val Asp Gly Thr Cys Asn 230235240245 taactttgg gacctatgtg cgt 858<210>22<211>245<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>22Met Ser Ile Glu Phe Ser Ala Pro Ala Lys Met Lys Ile Glu Val Trp 151015 Ser Asp Ile Met Cys Pro Phe Cys Tyr Ile Gly Lys Lys Arg Leu Asp

20 25 30Asp Ala Leu Ser Thr Phe Asp Gln Ala Gly Arg Ile Glu Val Glu Tyr

35 40 45Lys Ser Phe Glu Leu Met Pro Gly Leu Glu Thr His Pro Leu Arg Ser

50 55 60Asp Val Glu Tyr Leu Ala Asp Ala Lys Gly Met Ser Leu Glu Gln Ala 65 70 75 80Arg Gln Met Asn Gly Gln Val Gln Ala Met Ala Gln Ala Thr Gly Leu

85 90 95Glu Met Asn Pro Asp Glu Thr Ile Ala Ala Asn Thr Ile Asn Ala His

100 105 110Arg Leu Thr His Phe Ala Lys Ala His Gly Lys Gln Gln Glu Val Ala

115 120 125Gln Glu Leu Phe Lys Ala His Phe Val Asp Gly Lys Asn Val Asp Asp

130 135 140Leu Asp Val Leu Val Ser Ile Ala Ala Glu Val Gly Leu Asp Ala Ser145 150 155 160Ala Ala Arg Glu Ala Leu Glu Ser Asp Val Tyr Thr Asn Glu Val Gln

165 170 175Gln Asp Val His Glu Ala Arg Gln Leu Gly Val Gln Gly Val Pro Phe

180 185 190Phe Val Phe Asp Arg Lys Tyr Ala Ile Asn Gly Ala Gln Gln Glu Glu

195 200 205Val Phe Thr Gly Thr Val Glu Lys Ala Phe Glu Glu Trp Ala Ala Glu

210 215 220Asn Pro Val Ser Pro Phe Glu Val Ile Asp Gly Gln Ser Cys Ser Val225230 235 240Asp Gly Thr Cys Asn

245<210>23<211>1896<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1873)<223>RXA02335<400>23tggttgagtt cttcggggtt gagtgtgcaa gaatattcac tattggtcag gcaactatgt 60gtctacccac tgagtcatca atttaaatca ggagttatta gtg tca gtc gag act 115

Val Ser Val Glu Thr

1 5agg aag atc acc aag gtt ctt gtc gct aac cgt ggt gag att gca atc 163Arg Lys Ile Thr Lys Val Leu Val Ala Asn Arg Gly Glu Ile Ala Ile

10 15 20cgc gtg ttc cgt gca gct cga gat gaa ggc atg gga tct gtc gcc gtc 211Arg Val Phe Arg Ala Ala Arg Asp Glu Gly Met Gly Ser Val Ala Val

25 30 35tac gca gag cca gat gca gat gca cca ttc gtg tca tat gca gac gag 259Tyr Ala Glu Pro Asp Ala Asp Ala Pro Phe Val Ser Tyr Ala Asp Glu

40 45 50gct ttt gcc ctc ggt ggc caa aca tcc gct gag tcc tac ctt gtc att 307Ala Phe Ala Leu Gly Gly Gln Thr Ser Ala Glu Ser Tyr Leu Val Ile

55 60 65gac aag atc atc gat gcg gcc cgc aag tcc ggc gcc gac gcc atc cac 355Asp Lys Ile Ile Asp Ala Ala Arg Lys Ser Gly Ala Asp Ala Ile His 70 75 80 85ccc ggc tac ggc ttc ctc gca gaa aac gct gac ttc gca gaa gca gtc 403Pro Gly Tyr Gly Phe Leu Ala Glu Asn Ala Asp Phe Ala Glu Ala Val

90 95 100atc aac gaa ggc ctg atc tgg att gga cct tca cct gag tcc atc cgc 451Ile Asn Glu Gly Leu Ile Trp Ile Gly Pro Ser Pro Glu Ser Ile Arg

105 110 115tcc ctc ggc gac aag gtc acc gct cgc cac atc gca gat acc gcc aag 499Ser Leu Gly Asp Lys Val Thr Ala Arg His Ile Ala Asp Thr Ala Lys

120 125 130gct cca atg gct cct ggc acc aag gaa cca gta aaa gac gca gca gaa 547Ala Pro Met Ala Pro Gly Thr Lys Glu Pro Val Lys Asp Ala Ala Glu

135 140 145gtt gtg gct ttc gct gaa gaa ttc ggt ctc cca atc gcc atc aag gca 595Val Val Ala Phe Ala Glu Glu Phe Gly Leu Pro Ile Ala Ile Lys Ala150 155 160 165gct ttc ggt ggc ggc gga cgt ggc atg aag gtt gcc tac aag atg gaa 643Ala Phe Gly Gly Gly Gly Arg Gly Met Lys Val Ala Tyr Lys Met Glu

170 175 180gaa gtc gct gac ctc ttc gag tcc gca acc cgt gaa gca acc gca gcg 691Glu Val Ala Asp Leu Phe Glu Ser Ala Thr Arg Glu Ala Thr Ala Ala

185 190 195ttc ggc cgc ggc gag tgc ttc gtg gag cgc tac ctg gac aag gca cgc 739Phe Gly Arg Gly Glu Cys Phe Val Glu Arg Tyr Leu Asp Lys Ala Arg

200 205 210cac gtt gag gct cag gtc atc gcc gat aag cac ggc aac gtt gtt gtc 787His Val Glu Ala Gln Val Ile Ala Asp Lys His Gly Asn Val Val Val

215 220 225gcc gga acc cgt gac tgc tcc ctg cag cgc cgt ttc cag aag ctc gtc 835Ala Gly Thr Arg Asp Cys Ser Leu Gln Arg Arg Phe Gln Lys Leu Val230 235 240 245gaa gaa gca cca gca cca ttc ctc acc gat gac cag cgc gag cgt ctc 883Glu Glu Ala Pro Ala Pro Phe Leu Thr Asp Asp Gln Arg Glu Arg Leu

250 255 260cac tcc tcc gcg aag gct atc tgt aag gaa gct ggc tac tac ggt gca 931His Ser Ser Ala Lys Ala Ile Cys Lys Glu Ala Gly Tyr Tyr Gly Ala

265 270 275ggc acc gtt gag tac ctc gtt ggc tcc gac ggc ctg atc tcc ttc ctc 979Gly Thr Val Glu Tyr Leu Val Gly Ser Asp Gly Leu Ile Ser Phe Leu

280 285 290gag gtc aac acc cgc ctc cag gtg gaa cac cca gtc acc gaa gag acc 1027Glu Val Asn Thr Arg Leu Gln Val Glu His Pro Val Thr Glu Glu Thr

295 300 305acc ggc atc gac ctg gtc cgc gaa atg ttc cgc atc gca gaa ggc cac 1075Thr Gly Ile Asp Leu Val Arg Glu Met Phe Arg Ile Ala Glu Gly His310 315 320 325gag ctc tcc atc aag gaa gat cca gct cca cgc ggc cac gca ttc gag 1123Glu Leu Ser Ile Lys Glu Asp Pro Ala Pro Arg Gly His Ala Phe Glu

330 335 340ttc cgc atc aac ggc gaa gac gct ggc tcc aac ttc atg cct gca cca 1171Phe Arg Ile Asn Gly Glu Asp Ala Gly Ser Asn Phe Met Pro Ala Pro

345 350 355ggc aag atc acc agc tac cgc gag cca cag ggc cca ggc gtc cgc atg 1219Gly Lys Ile Thr Ser Tyr Arg Glu Pro Gln Gly Pro Gly ValArg Met

360 365 370gac tcc ggt gtc gtt gaa ggt tcc gaa atc tcc gga cag ttc gac tcc 1267Asp Ser Gly Val Val Glu Gly Ser Glu Ile Ser Gly Gln Phe Asp Ser

375 380 385atg ctg gca aag ctg atc gtt tgg ggc gac acc cgc gag cag gct ctc 1315Met Leu Ala Lys Leu Ile Val Trp Gly Asp Thr Arg Glu Gln Ala Leu390 395 400 405cag cgc tcc cgc cgt gca ctt gca gag tac gtt gtc gag ggc atg cca 1363Gln Arg Ser Arg Arg Ala Leu Ala Glu Tyr Val Val Glu Gly Met Pro

410 415 420acc gtt atc cca ttc cac cag cac atc gtg gaa aac cca gca ttc gtg 1411Thr Val Ile Pro Phe His Gln His Ile Val Glu Asn Pro Ala Phe Val

425 430 435ggc aac gac gaa ggc ttc gag atc tac acc aag tgg atc gaa gag gtt 1459Gly Asn Asp Glu Gly Phe Glu Ile Tyr Thr Lys Trp Ile Glu Glu Val

440 445 450tgg gat aac cca atc gca cct tac gtt gac gct tcc gag ctc gac gaa 1507Trp Asp Asn Pro Ile Ala Pro Tyr Val Asp Ala Ser Glu Leu Asp Glu

455 460 465gat gag gac aag acc cca gca cag aag gtt gtt gtg gag atc aac ggc 1555Asp Glu Asp Lys Thr Pro Ala Gln Lys Val Val Val Glu Ile Asn Gly470 475 480 485cgt cgc gtt gag gtt gca ctc cca ggc gat ctg gca ctc ggt ggc acc 1603Arg Arg Val Glu Val Ala Leu Pro Gly Asp Leu Ala Leu Gly Gly Thr

490 495 500gct ggt cct aag aag aag gcc aag aag cgt cgc gca ggt ggt gca aag 1651Ala Gly Pro Lys Lys Lys Ala Lys Lys Arg Arg Ala Gly Gly Ala Lys

505 510 515gct ggc gta tcc ggc gat gca gtg gca gct cca atg cag ggc act gtc 1699Ala Gly Val Ser Gly Asp Ala Val Ala Ala Pro Met Gln Gly Thr Val

520 525 530atc aag gtc aac gtc gaa gaa ggc gct gaa gtc aac gaa ggc gac acc 1747Ile Lys Val Asn Val Glu Glu Gly Ala Glu Val Asn Glu Gly Asp Thr

535 540 545gtt gtt gtc ctc gag gct atg aag atg gaa aac cct gtg aag gct cat 1795Val Val Val Leu Glu Ala Met Lys Met Glu Asn Pro Val Lys Ala His550 555 560 565aag tcc gga acc gta acc ggc ctt act gtc gct gca ggc gag ggt gtc 1843Lys Ser Gly Thr Val Thr Gly Leu Thr Val Ala Ala Gly Glu Gly Val

570 575 580aac aag ggc gtt gtt ctc ctc gag atc aag taagttcttg gattcctgtt 1893Asn Lys Gly Val Val Leu Leu Glu Ile Lys

585590 agt1896<210>24<211>591<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>24Val Ser Val Glu Thr Arg Lys Ile Thr Lys Val Leu Val Ala Asn Arg 151015 Gly Glu Ile Ala Ile Arg Val Phe Arg Ala Ala Arg Asp Glu Gly Met

20 25 30Gly Ser Val Ala Val Tyr Ala Glu Pro Asp Ala Asp Ala Pro Phe Val

35 40 45Ser Tyr Ala Asp Glu Ala Phe Ala Leu Gly Gly Gln Thr Ser Ala Glu

50 55 60Ser Tyr Leu Val Ile Asp Lys Ile Ile Asp Ala Ala Arg Lys Ser Gly 65 70 75 80Ala Asp Ala Ile His Pro Gly Tyr Gly Phe Leu Ala Glu Asn Ala Asp

85 90 95Phe Ala Glu Ala Val Ile Asn Glu Gly Leu Ile Trp Ile Gly Pro Ser

100 105 110Pro Glu Ser Ile Arg Ser Leu Gly Asp Lys Val Thr Ala Arg His Ile

115 120 125Ala Asp Thr Ala Lys Ala Pro Met Ala Pro Gly Thr Lys Glu Pro Val

130 135 140Lys Asp Ala Ala Glu Val Val Ala Phe Ala Glu Glu Phe Gly Leu Pro145 150 155 160Ile Ala Ile Lys Ala Ala Phe Gly Gly Gly Gly Arg Gly Met Lys Val

165 170 175Ala Tyr Lys Met GluGlu Val Ala Asp Leu Phe Glu Ser Ala Thr Arg

180 185 190Glu Ala Thr Ala Ala Phe Gly Arg Gly Glu Cys Phe Val Glu Arg Tyr

195 200 205Leu Asp Lys Ala Arg His Val Glu Ala Gln Val Ile Ala Asp Lys His

210 215 220Gly Asn Val Val Val Ala Gly Thr Arg Asp Cys Ser Leu Gln Arg Arg225 230 235 240Phe Gln Lys Leu Val Glu Glu Ala Pro Ala Pro Phe Leu Thr Asp Asp

245 250 255Gln Arg Glu Arg Leu His Ser Ser Ala Lys Ala Ile Cys Lys Glu Ala

260 265 270Gly Tyr Tyr Gly Ala Gly Thr Val Glu Tyr Leu Val Gly Ser Asp Gly

275 280 285Leu Ile Ser Phe Leu Glu Val Asn Thr Arg Leu Gln Val Glu His Pro

290 295 300Val Thr Glu Glu Thr Thr Gly Ile Asp Leu Val Arg Glu Met Phe Arg305 310 315 320Ile Ala Glu Gly His Glu Leu Ser Ile Lys Glu Asp Pro Ala Pro Arg

325 330 335Gly His Ala Phe Glu Phe Arg Ile Asn Gly Glu Asp Ala Gly Ser Asn

340 345 350Phe Met Pro Ala Pro Gly Lys Ile Thr Ser Tyr Arg Glu Pro Gln Gly

355 360 365Pro Gly Val Arg Met Asp Ser Gly Val Val Glu Gly Ser Glu Ile Ser

370 375 380Gly Gln Phe Asp Ser Met Leu Ala Lys Leu Ile Val Trp Gly Asp Thr385 390 395 400Arg Glu Gln Ala Leu Gln Arg Ser Arg Arg Ala Leu Ala Glu Tyr Val

405 410 415Val Glu Gly Met Pro Thr Val Ile Pro Phe His Gln His Ile Val Glu

420 425 430Asn Pro Ala Phe Val Gly Asn Asp Glu Gly Phe Glu Ile Tyr Thr Lys

435 440 445Trp Ile Glu Glu Val Trp Asp Asn Pro Ile Ala Pro Tyr Val Asp Ala

450 455 460Ser Glu Leu Asp Glu Asp Glu Asp Lys Thr Pro Ala Gln Lys Val Val465 470 475 480Val Glu Ile Asn Gly Arg Arg Val Glu Val Ala Leu Pro Gly Asp Leu

485 490 495Ala Leu Gly Gly Thr Ala Gly Pro Lys Lys Lys Ala Lys Lys Arg Arg

500 505 510Ala Gly Gly Ala Lys Ala Gly Val Ser Gly Asp Ala Val Ala Ala Pro

515 520 525Met Gln Gly Thr Val Ile Lys Val Asn Val Glu Glu Gly Ala Glu Val

530 535 540Asn Glu Gly Asp Thr Val Val Val Leu Glu Ala Met Lys Met Glu Asn545 550 555 560Pro Val Lys Ala His Lys Ser Gly Thr Val Thr Gly Leu Thr Val Ala

565 570 575Ala Gly Glu Gly Val Asn Lys Gly Val Val Leu Leu Glu Ile Lys

580585590<210>25<211>1575<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><22l>CDS<222>(101). (1552)<223>RXA02173<400>25ctaaattggg cttagatctt ccgcctctaa ataggtatgc agagacattc gaattaatta 60acaaagccat ttttcggccg tggagaagcg ttttccgact atg gtg tgg ggc atg 115

Met Val Trp Gly Met

1 5gaa cac act tca gca ttg acg ctc ata gac tcg gtt ttg gac cct gac 163Glu His Thr Ser Ala Leu Thr Leu Ile Asp Ser Val Leu Asp Pro Asp

10 15 20agc ttc att tct tgg aat gaa act ccc caa tat gac aac ctc aat caa 211Ser Phe Ile Ser Trp Asn Glu Thr Pro Gln Tyr Asp Asn Leu Asn Gln

25 30 35ggc tat gca gag acc ttg gag cgg gct cga agc aag gcc aaa tgc gat 259Gly Tyr Ala Glu Thr Leu Glu Arg Ala Arg Ser Lys Ala Lys Cys Asp

40 45 50gaa tcg gta att act gga gaa ggc acc gtg gag ggc att ccg gta gcc 307Glu Ser Val Ile Thr Gly Glu Gly Thr Val Glu Gly Ile Pro Val Ala

55 60 65gtt att ttg tcc gat ttt tcc ttc ctc ggc ggt tct ttg ggc acg gtc 355Val Ile Leu Ser Asp Phe Ser Phe Leu Gly Gly Ser Leu Gly Thr Val 70 75 80 85gcg tcg gtg cgc atc atg aag gcg att cac cgc gcc aca gag ctg aaa 403Ala Ser Val Arg Ile Met Lys Ala Ile His Arg Ala Thr Glu Leu Lys

90 95 100ctc cca ctg ctg gtc tcc cct gct tcc ggt ggt gcg cgc atg cag gaa 451Leu Pro Leu Leu Val Ser Pro Ala Ser Gly Gly Ala Arg Met Gln Glu

105 110 115gac aat cga gct ttt gtc atg atg gtg tcc ata acc gcg gct gtg cag 499Asp Asn Arg Ala Phe Val Met Met Val Ser Ile Thr Ala Ala Val Gln

120 125 130cgt cac cgc gag gcg cat ttg ccg ttc ctg gtg tat ttg cgc aat ccc 547Arg His Arg Glu Ala His Leu Pro Phe Leu Val Tyr Leu Arg Asn Pro

135 140 145acg atg ggt ggc gcc atg gcc tcg tgg ggt tca tct ggg cat ctc act 595Thr Met Gly Gly Ala Met Ala Ser Trp Gly Ser Ser Gly His Leu Thr150 155 160 165ttt gcg gaa ccc ggc gcg cag ata ggt ttc ctg ggt cct cgc gtg gtg 643Phe Ala Glu Pro Gly Ala Gln Ile Gly Phe Leu Gly Pro Arg Val Val

170 175 180gag tta acc act ggg cat gcg ctt cca gac ggt gtg cag cag gcg gag 691Glu Leu Thr Thr Gly His Ala Leu Pro Asp Gly Val Gln Gln Ala Glu

185 190 195aat ttg gtg aaa act ggt gtg att gat gga att gtg tcg cca ctc caa 739Asn Leu Val Lys Thr Gly Val Ile Asp Gly Ile Val Ser Pro Leu Gln

200 205 210ttg cgt gca gcg gtg gca aaa acc crc aag gtt att cag ccg gta gag 787Leu Arg Ala Ala Val Ala Lys Thr Leu Lys Val Ile Gln Pro Val Glu

215 220 225gca acg gat cgt ttt tct cca aca act cct ggc gtg gca ctt ccg gtg 835Ala Thr Asp Arg Phe Ser Pro Thr Thr Pro Gly Val Ala Leu Pro Val230 235 240 245atg gag gcg att gcg cgt tct cgt gac ccg cag agg cct gga atc ggg 883Met Glu Ala Ile Ala Arg Ser Arg Asp Pro Gln Arg Pro Gly Ile Gly

250 255 260gag att atg gaa acg ttg ggg gca gac gtc gtc aag ctt tct ggt gcg 931Glu Ile Met Glu Thr Leu Gly Ala Asp Val Val Lys Leu Ser Gly Ala

265 270 275cgt gct ggc gca ttg agc ccg gct gtg cgc gtt gcc ctg gcg cgc arc 979Arg Ala Gly Ala Leu Ser Pro Ala Val Arg Val Ala Leu Ala Arg Ile

280 285 290ggg ggc cgg ccc gtg gtg ctg att ggg cag gat cgc cgc ttc acg ctt 1027Gly Gly Arg Pro Val Val Leu Ile Gly Gln Asp Arg Arg Phe Thr Leu

295 300 305ggg ccg cag gag ctg cgt ttt gcg cgt cgt ggc att tcg ctg gcg cgc 1075Gly Pro Gln Glu Leu Arg Phe Ala Arg Arg Gly Ile Ser Leu Ala Arg310 315 320 325gag cta aac ctg ccg atc gtg tcc atc atc gac acc tcc ggc gcc gaa 1123Glu Leu Asn Leu Pro Ile Val Ser Ile Ile Asp Thr Ser Gly Ala Glu

330 335 340ttg tcg cag gcg gct gag gag ctc ggc atc gca agc tcg att gcg cgc 1171Leu Ser Gln Ala Ala Glu Glu Leu Gly Ile Ala Ser Ser Ile Ala Arg

345 350 355acc ttg tcc aag ctt atc gac gct ccc ctc ccc acc gtt tcg gtc att 1219Thr Leu Ser Lys Leu Ile Asp Ala Pro Leu Pro Thr Val Ser Val Ile

360 365 370att ggt cag ggc gtt ggc ggt ggc gcg ctg gcc atg ctg ccc gcc gat 1267Ile Gly Gln Gly Val Gly Gly Gly Ala Leu Ala Met Leu Pro Ala Asp

375 380 385ctg gtc tac gcg gcc gaa aac gcg tgg ctg tcc gca ttg cca cca gag 1315Leu Val Tyr Ala Ala Glu Asn Ala Trp Leu Ser Ala Leu Pro Pro Glu390 395 400 405ggc gcc tcg gcc atc ctc ttc cgc gac acc aac cac gcc gcg gaa atc 1363Gly Ala Ser Ala Ile Leu Phe Arg Asp Thr Asn His Ala Ala Glu Ile

410 415 420ata gag cga caa ggc gtg cag gcg cac gca ctt tta agc caa ggg ctt 1411Ile Glu Arg Gln Gly Val Gln Ala His Ala Leu Leu Ser Gln Gly Leu

425 430 435atc gac ggg atc gtc gcc gaa acc gag cac ttt gtt gaa gaa att ctc 1459Ile Asp Gly Ile Val Ala Glu Thr Glu His Phe Val Glu Glu Ile Leu

440445 450ggc aca atc agc aac gcc ctc tcc gaa ttg gat aac aat ccg gag agg 1507Gly Thr Ile Ser Asn Ala Leu Ser Glu Leu Asp Asn Asn Pro Glu Arg

455460465 gcg gga cgc gac agt cgc ttc aca cga ttt gag cgt tta gcg cag 1552Ala Gly Arg Asp Ser Arg Phe Thr Arg Phe Glu Arg Leu Ala Gln 470475480 taaagaaaat tatgcgctga tca 1575<210>26<211>484<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>26Met Val Trp Gly Met Glu His Thr Ser Ala Leu Thr Leu Ile Asp Ser 151015 Val Leu Asp Pro Asp Ser Phe Ile Ser Trp Asn Glu Thr Pro Gln Tyr

20 25 30Asp Asn Leu Asn Gln Gly Tyr Ala Glu Thr Leu Glu Arg Ala Arg Ser

35 40 45Lys Ala Lys Cys Asp Glu Ser Val Ile Thr Gly Glu Gly Thr Val Glu

50 55 60Gly Ile Pro Val Ala Val Ile Leu Ser Asp Phe Ser Phe Leu Gly Gly 65 70 75 80Ser Leu Gly Thr Val Ala Ser Val Arg Ile Met Lys Ala Ile His Arg

85 90 95Ala Thr Glu Leu Lys Leu Pro Leu Leu Val Ser Pro Ala Ser Gly Gly

100 105 110Ala Arg Met Gln Glu Asp Asn Arg Ala Phe Val Met Met Val Ser Ile

115 120 125Thr Ala Ala Val Gln Arg His Arg Glu Ala His Leu Pro Phe Leu Val

130 135 140Tyr Leu Arg Asn Pro Thr Met Gly Gly Ala Met Ala Ser Trp Gly Ser145 150 155 160Ser Gly His Leu Thr Phe Ala Glu Pro Gly Ala Gln Ile Gly Phe Leu

165 170 175Gly Pro Arg ValVal Glu Leu Thr Thr Gly His Ala Leu Pro Asp Gly

180 185 190Val Gln Gln Ala Glu Asn Leu Val Lys Thr Gly Val Ile Asp Gly Ile

195 200 205Val Ser Pro Leu Gln Leu Arg Ala Ala Val Ala Lys Thr Leu Lys Val

210 215 220Ile Gln Pro Val Glu Ala Thr Asp Arg Phe Ser Pro Thr Thr Pro Gly225 230 235 240Val Ala Leu Pro Val Met Glu Ala Ile Ala Arg Ser Arg Asp Pro Gln

245 250 255Arg Pro Gly Ile Gly Glu Ile Met Glu Thr Leu Gly Ala Asp Val Val

260 265 270Lys Leu Ser Gly Ala Arg Ala Gly Ala Leu Ser Pro Ala Val Arg Val

275 280 285Ala Leu Ala Arg Ile Gly Gly Arg Pro Val Val Leu Ile Gly Gln Asp

290 295 300Arg Arg Phe Thr Leu Gly Pro Gln Glu Leu Arg Phe Ala Arg Arg Gly305 310 315 320Ile Ser Leu Ala Arg Glu Leu Asn Leu Pro Ile Val Ser Ile Ile Asp

325 330 335Thr Ser Gly Ala Glu Leu Ser Gln Ala Ala Glu Glu Leu Gly Ile Ala

340 345 350Ser Ser Ile Ala Arg Thr Leu Ser Lys Leu Ile Asp Ala Pro Leu Pro

355 360 365Thr Val Ser Val Ile Ile Gly Gln Gly Val Gly Gly Gly Ala Leu Ala

370 375 380Met Leu Pro Ala Asp Leu Val Tyr Ala Ala Glu Asn Ala Trp Leu Ser385 390 395 400Ala Leu Pro Pro Glu Gly Ala Ser Ala Ile Leu Phe Arg Asp Thr Asn

405 410 415His Ala Ala Glu Ile Ile Glu Arg Gln Gly Val Gln Ala His Ala Leu

420 425 430Leu Ser Gln Gly Leu Ile Asp Gly Ile Val Ala Glu Thr Glu His Phe

435 440 445Val Glu Glu Ile Leu Gly Thr Ile Ser Asn Ala Leu Ser Glu Leu Asp

450455460 Asn Asn Pro Glu Arg Ala Gly Arg Asp Ser Arg Phe Thr Arg Phe Glu 465470475480 Arg Leu Ala Gln<210>27<211>1056<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1033)<223>RXA01764<400>27ttttcaaaat taatagttga cattttcaac gttatgagtt ttcattggta tcacgccccg 60acgaagtgtc tgggatcaca aaccttcaaa ggagtttgaa atg tct crc aat gga 115

Met Ser Leu Asn Gly

1 5aaa gtc gcc atc gtt acc gga tct ggt gca gga ctt ggt cgt tcc ttc 163Lys Val Ala Ile Val Thr Gly Ser Gly Ala Gly Leu Gly Arg Ser Phe

10 15 20gct cag gag ctt gcc cgt cag ggt gca tct gtc atc gtc aat gac gta 211Ala Gln Glu Leu Ala Arg Gln Gly Ala Ser Val Ile Val Asn Asp Val

25 30 35aac cag gca gcc gca gat gag act gtc gca gca atc acc gaa gcc ggc 259Asn Gln Ala Ala Ala Asp Glu Thr Val Ala Ala Ile Thr Glu Ala Gly

40 45 50ggc aaa gcc gcc gcc gtt atc gcc ccc gtt gga ccc tct gaa agc gcc 307Gly Lys Ala Ala Ala Val Ile Ala Pro Val Gly Pro Ser Glu Ser Ala

55 60 65gca ttg ctg gtgcgg gag gcc gtc gac aag ttc ggt tct ttg gac att 355Ala Leu Leu Val Arg Glu Ala Val Asp Lys Phe Gly Ser Leu Asp Ile 70 75 80 85ctt gtc aca aac gcg ggc atc ctt cgt gat agg tcc ctg ctg aag atg 403Leu Val Thr Asn Ala Gly Ile Leu Arg Asp Arg Ser Leu Leu Lys Met

90 95 100acg gac gat gat ttc gat gca gtc att aac gtg cac ctc aag ggc act 451Thr Asp Asp Asp Phe Asp Ala Val Ile Asn Val His Leu Lys Gly Thr

105 110 115ttc acc tgt gtt cgc gag gca ttt gga tac ttc aag gag aat gga atc 499Phe Thr Cys Val Arg Glu Ala Phe Gly Tyr Phe Lys Glu Asn Gly Ile

120 125 130gcg ggg cgc atc gtc acg att ggt tct ccc acc ggg cag cgc ggc aac 547Ala Gly Arg Ile Val Thr Ile Gly Ser Pro Thr Gly Gln Arg Gly Asn

135 140 145ttc gga cag agc aat tac gct gca gct aag gcg ggc att gtg ggt atg 595Phe Gly Gln Ser Asn Tyr Ala Ala Ala Lys Ala Gly Ile Val Gly Met150 155 160 165gtt cgc acg tgg gcg ctg gag atg aag cgc gca ggt gtc acc att aac 643Val Arg Thr Trp Ala Leu Glu Met Lys Arg Ala Gly Val Thr Ile Asn

170 175 180gcg atc att ccg gaa gca gcc acc gat atg acc aag acg gtg cca tat 691Ala Ile Ile Pro Glu Ala Ala Thr Asp Met Thr Lys Thr Val Pro Tyr

185 190 195ttc cag aag gct gta gag gcc gat gag cgt ggc gag gcc atg cca gca 739Phe Gln Lys Ala Val Glu Ala Asp Glu Arg Gly Glu Ala Met Pro Ala

200 205 210ttc ttc cgc gag acc cta ggt ttt ggc act cct cag gat gtt gcg gga 787Phe Phe Arg Glu Thr Leu Gly Phe Gly Thr Pro Gln Asp Val Ala Gly

215 220 225ctt gtg gcc ttc ctt tcc tct gat gag gca gcg aat att tct gga cag 835Leu Val Ala Phe Leu Ser Ser Asp Glu Ala Ala Asn Ile Ser Gly Gln230 235 240 245gcc atc ggt gca ggc ggc gac cgc atg cag gtg tgg aag cac cca gag 883Ala Ile Gly Ala Gly Gly Asp Arg Met Gln Val Trp Lys His Pro Glu

250 255 260cca gca gtt act gaa ttt aac cca ggt ggc tgg acc tat gaa gca ctg 931Pro Ala Val Thr Glu Phe Asn Pro Gly Gly Trp Thr Tyr Glu Ala Leu

265 270 275cag gaa cgt ggc aag aac att att gag ggc aac ctg cag tcc gtc ggt 979Gln Glu Arg Gly Lys Asn Ile Ile Glu Gly Asn Leu Gln Ser Val Gly

280 285 290gtc gtt ttc cct gaa ctg ccg gca gag ctt cag cca caa atc cca gtc 1027Val Val Phe Pro Glu Leu Pro Ala Glu Leu Gln Pro Gln Ile Pro Val

295300305 aag gca taacaccgca caccaagaat ttt 1056Lys Ala310<210>28<211>311<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>28Met Ser Leu Asn Gly Lys Val Ala Ile Val Thr Gly Ser Gly Ala Gly 151015 Leu Gly Arg Ser Phe Ala Gln Glu Leu Ala Arg Gln Gly Ala Ser Val

20 25 30Ile Val Asn Asp Val Asn Gln Ala Ala Ala Asp Glu Thr Val Ala Ala

35 40 45Ile Thr Glu Ala Gly Gly Lys Ala Ala Ala Val Ile Ala Pro Val Gly

50 55 60Pro Ser Glu Ser Ala Ala Leu Leu Val Arg Glu Ala Val Asp Lys Phe 65 70 75 80Gly Ser Leu Asp Ile Leu Val Thr Asn Ala Gly Ile Leu Arg Asp Arg

8590 95Ser Leu Leu Lys Met Thr Asp Asp Asp Phe Asp Ala Val Ile Asn Val

100 105 110His Leu Lys Gly Thr Phe Thr Cys Val Arg Glu Ala Phe Gly Tyr Phe

115 120 125Lys Glu Asn Gly Ile Ala Gly Arg Ile Val Thr Ile Gly Ser Pro Thr

130 135 140Gly Gln Arg Gly Asn Phe Gly Gln Ser Asn Tyr Ala Ala Ala Lys Ala145 150 155 160Gly Ile Val Gly Met Val Arg Thr Trp Ala Leu Glu Met Lys Arg Ala

165 170 175Gly Val Thr Ile Asn Ala Ile Ile Pro Glu Ala Ala Thr Asp Met Thr

180 185 190Lys Thr Val Pro Tyr Phe Gln Lys Ala Val Glu Ala Asp Glu Arg Gly

195 200 205Glu Ala Met Pro Ala Phe Phe Arg Glu Thr Leu Gly Phe Gly Thr Pro

210 215 220Gln Asp Val Ala Gly Leu Val Ala Phe Leu Ser Ser Asp Glu Ala Ala225 230 235 240Asn Ile Ser Gly Gln Ala Ile Gly Ala Gly Gly Asp Arg Met Gln Val

245 250 255Trp Lys Hls Pro Glu Pro Ala Val Thr Glu Phe Asn Pro Gly Gly Trp

260 265 270Thr Tyr Glu Ala Leu Gln Glu Arg Gly Lys Asn Ile Ile Glu Gly Asn

275 280 285Leu Gln Ser Val Gly Val Val Phe Pro Glu Leu Pro Ala Glu Leu Gln

290295300 Pro Gln Ile Pro Val Lys Ala 305310<210>29<211>1827<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1804)<223>RXN02487<400>29tcatagctac gcgcatgccc acattctaga tcgccgaaga aagcagcggg acgtctctat 60atactaaagg gcactaaagc aacgcagttg aagggacacc atg tca gca tac gaa 115

Met Ser Ala Tyr Glu

1 5acc aaa gaa tgg ctc cag cac tac cca gag tgg acg cca cac tcg ctg 163Thr Lys Glu Trp Leu Gln His Tyr Pro Glu Trp Thr Pro His Ser Leu

10 15 20gaa tat ggc gac acc acc ctg ctg gac gtt tac gac aac aac ctg gcc 211Glu Tyr Gly Asp Thr Thr Leu Leu Asp Val Tyr Asp Asn Asn Leu Ala

25 30 35att aac gca gac aag cca gcc acc tac ttt ttc ggt cgt tca caa acc 259Ile Asn Ala Asp Lys Pro Ala Thr Tyr Phe Phe Gly Arg Ser Gln Thr

40 45 50tac ggt gaa ctg gac aaa gaa gtc cgc aaa act gcc gct ggc ctg cgc 307Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr Ala Ala Gly Leu Arg

55 60 65gca cta ggt gtc cgc ccc ggc gat cac gta gcg att atc ctc ccc aac 355Ala Leu Gly Val Arg Pro Gly Asp His Val Ala Ile Ile Leu Pro Asn 70 75 80 85tgc cca cag cac atc gca gct ttc tac gca gtg ctg aaa ctc ggc gca 403Cys Pro Gln His Ile Ala Ala Phe Tyr Ala Val Leu Lys Leu Gly Ala

90 95 100gta gtc att gag cac aac ccg ctc tac acc gcc cac gaa ctg ctc gaa 451Val Val Ile Glu His Asn Pro Leu Tyr Thr Ala His Glu Leu Leu Glu

105 110 115ccc ttc aaa gac cac ggt gcc cgc gtt gcc atc gtc tgg gac aaa gcc 499Pro Phe Lys Asp His Gly Ala Arg Val AlaIle Val Trp Asp Lys Ala

120 125 130tcc ccc acc gtc gaa cag cta cgt gga cag acc cag ttg gaa acc atc 547Ser Pro Thr Val Glu Gln Leu Arg Gly Gln Thr Gln Leu Glu Thr Ile

135 140 145gtg tcg gtc aac atg atc aac gcg atg cca cca ctc cag cgc cta gca 595Val Ser Val Asn Met Ile Asn Ala Met Pro Pro Leu Gln Arg Leu Ala150 155 160 165ctt cgg ctc cca arc cct gca ctg cgc aag agc cgc gaa tcc ctc tcc 643Leu Arg Leu Pro Ile Pro Ala Leu Arg Lys Ser Arg Glu Ser Leu Ser

170 175 180ggc gca gcc ccc aac acc gtt cct ttt gaa acc ctg acc agc gca gca 691Gly Ala Ala Pro Asn Thr Val Pro Phe Glu Thr Leu Thr Ser Ala Ala

185 190 195atg ggc ggc gac ggc gac gac gta gtt tca gaa ccc acc gtg acc aaa 739Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu Pro Thr Val Thr Lys

200 205 210gaa tcc gtc gcg ctg atc ctc tac acc tcc ggc acc acc gga cgc ccc 787Glu Ser Val Ala Leu Ile Leu Tyr Thr Ser Gly Thr Thr Gly Arg Pro

215 220 225aag ggt gcc cag ctc acc cac gga aac ctg ttc ttc aat ctt ctt caa 835Lys Gly Ala Gln Leu Thr His Gly Asn Leu Phe Phe Asn Leu Leu Gln230 235 240 245gga aag cac tgg gtt cca ggt ctc gga gac aaa cca gaa cgc atg ctt 883Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys Pro Glu Arg Met Leu

250 255 260gca gcc cta cca atg ttc cac gca tac ggt ctg acc atg gtc ggc aca 931Ala Ala Leu Pro Met Phe His Ala Tyr Gly Leu Thr Met Val Gly Thr

265 270 275ctg tcc gtg ttc atc ggt ggc gaa atg gtg cta ctt ccc acc cca cgc 979Leu Ser Val Phe Ile Gly Gly Glu Met Val Leu Leu Pro Thr Pro Arg

280 285 290atc gac ctg atc atg aac gta atg aaa aag cac acc cca acc tgg cta 1027Ile Asp Leu Ile Met Asn Val Met Lys Lys His Thr Pro Thr Trp Leu

295 300 305cca ggc gtg ccc acc ctt tac gaa aaa atc gtc gac gcc tcc gaa aaa 1075Pro Gly Val Pro Thr Leu Tyr Glu Lys Ile Val Asp Ala Ser Glu Lys310 315 320 325gaa gga atc ccc atc aag gga gtc cgc aac gcc ttc tcc ggt gca tcc 1123Glu Gly Ile Pro Ile Lys Gly Val Arg Asn Ala Phe Ser Gly Ala Ser

330 335 340aca ctc tcc cag cgc acc gtt gaa cgc tgg gaa aag cac acc ggc gga 1171Thr Leu Ser Gln Arg Thr Val Glu Arg Trp Glu Lys His Thr Gly Gly

345 350 355cgc ctc gtc gaa ggc tac ggc ctc acc gaa acc tcc ccc atc atc gtg 1219Arg Leu Val Glu Gly Tyr Gly Leu Thr Glu Thr Ser Pro Ile Ile Val

360 365 370ggt aac ccc atg agc gat cac cga cgc caa ggc tac gta gga atc ccc 1267Gly Asn Pro Met Ser Asp His Arg Arg Gln Gly Tyr Val Gly Ile Pro

375 380 385ttc ccc gac acc atc gtg cgc atc gca aac cca gaa aac ctc gac gaa 1315Phe Pro Asp Thr Ile Val Arg Ile Ala Asn Pro Glu Asn Leu Asp Glu390 395 400 405acc atg ccc gac ggc agc gaa ggc gaa gtc cta gtc aag ggc cca cag 1363Thr Met Pro Asp Gly Ser Glu Gly Glu Val Leu Val Lys Gly Pro Gln

410 415 420gtg ttc aag ggt tac ctc aac cag gaa gaa gcc acc aag aac agc ttc 1411Val Phe Lys Gly Tyr Leu Asn Gln Glu Glu Ala Thr Lys Asn Ser Phe

425 430 435cac ggc gag tgg tac cgc acc ggc gac gtc gga gtg atg gaa gaa gac 1459His Gly Glu Trp Tyr Arg Thr Gly Asp Val Gly Val Met Glu Glu Asp

440 445 450ggg ttc atc cgc cta gtt gct cgc atc aag gaa gtc atc atc act ggc 1507Gly Phe Ile Arg Leu Val Ala Arg Ile Lys Glu Val Ile Ile Thr Gly

455 460 465ggt ttc aac gtg tac cca gct gag gtt gaa gaa gtc ctc gca gag cac 1555Gly Phe Asn Val Tyr Pro Ala Glu Val Glu Glu Val Leu Ala Glu His470 475 480 485cca gac att gaa gat tcc gca gtc gtt ggt atc ccg cgt gaa gac ggc 1603Pro Asp Ile Glu Asp Ser Ala Val Val Gly Ile Pro Arg Glu Asp Gly

490 495 500tcc gaa aac gtc gtt gct gcc atc act ttg gtg gaa ggt gca gcg ctg 1651Ser Glu Asn Val Val Ala Ala Ile Thr Leu Val Glu Gly Ala Ala Leu

505 510 515gat ccg gat ggc ctg aag gaa ttc gcc cgc aag aac ctc acc cgc tac 1699Asp Pro Asp Gly Leu Lys Glu Phe Ala Arg Lys Asn Leu Thr Arg Tyr

520 525 530aag gtt ccg cgc act ttc tac cac ttt gag gag atg ccg cgg gat cag 1747Lys Val Pro Arg Thr Phe Tyr His Phe Glu Glu Met Pro Arg Asp Gln

535540545 atg ggc aag att agg cgt cgt gaa gtg cag gcg gag ttg ttg aag aag 1795Met Gly Lys Ile Arg Arg Arg Glu Val Gln Ala Glu Leu Leu Lys Lys 550555560565 ctc ggc aag tagacgccga tttaagaggt cga 1827Leu Gly Lys<210>30<211>568<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>30Met Ser Ala Tyr Glu Thr Lys Glu Trp Leu Gln His Tyr Pro Glu Trp 151015 Thr Pro His Ser Leu Glu Tyr Gly Asp Thr Thr Leu Leu Asp Val Tyr

20 25 30Asp Asn Asn Leu Ala Ile Asn Ala Asp Lys Pro Ala Thr Tyr Phe Phe

35 40 45Gly Arg Ser Gln Thr Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr

50 55 60Ala Ala Gly Leu Arg Ala Leu Gly Val Arg Pro Gly Asp His Val Ala 65 70 75 80Ile Ile Leu Pro Asn Cys Pro Gln His Ile Ala Ala Phe Tyr Ala Val

85 90 95Leu Lys Leu Gly Ala Val Val Ile Glu His Asn Pro Leu Tyr Thr Ala

100 105 110His Glu Leu Leu Glu Pro Phe Lys Asp His Gly Ala Arg Val Ala Ile

115 120 125Val Trp Asp Lys Ala Ser Pro Thr Val Glu Gln Leu Arg Gly Gln Thr

130 135 140Gln Leu Glu Thr Ile Val Ser Val Asn Met Ile Asn Ala Met Pro Pro145 150 155 160Leu Gln Arg Leu Ala Leu Arg Leu Pro Ile Pro Ala Leu Arg Lys Ser

165 170 175Arg Glu Ser Leu Ser Gly Ala Ala Pro Asn Thr Val Pro Phe Glu Thr

180 185 190Leu Thr Ser Ala Ala Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu

195 200 205Pro Thr Val Thr Lys Glu Ser Val Ala Leu Ile Leu Tyr Thr Ser Gly

210 215 220Thr Thr Gly Arg Pro Lys Gly Ala Gln Leu Thr His Gly Asn Leu Phe225 230 235 240Phe Asn Leu Leu Gln Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys

245 250 255Pro Glu Arg Met Leu Ala Ala Leu Pro Met Phe His Ala Tyr Gly Leu

260 265 270Thr Met Val Gly Thr Leu Ser Val Phe Ile Gly Gly Glu Met Val Leu

275 280 285Leu Pro Thr Pro Arg Ile Asp Leu Ile Met Asn Val Met Lys Lys His

290 295 300Thr Pro Thr Trp Leu Pro Gly Val Pro Thr Leu Tyr Glu Lys Ile Val305 310 315 320Asp Ala Ser Glu Lys Glu Gly Ile Pro Ile Lys Gly Val Arg Asn Ala

325 330 335Phe Ser Gly Ala Ser Thr Leu Ser Gln Arg Thr Val Glu Arg Trp Glu

340 345 350Lys His Thr Gly Gly Arg Leu Val Glu Gly Tyr Gly Leu Thr Glu Thr

355 360 365Ser Pro Ile Ile Val Gly Asn Pro Met Ser Asp His Arg Arg Gln Gly

370 375 380Tyr Val Gly Ile Pro Phe Pro Asp Thr Ile Val Arg Ile Ala Asn Pro385 390 395 400Glu Asn Leu Asp Glu Thr Met Pro Asp Gly Ser Glu Gly Glu Val Leu

405 410 415Val Lys Gly Pro Gln Val Phe Lys Gly Tyr Leu Asn Gln Glu Glu Ala

420 425 430Thr Lys Asn Ser Phe His Gly Glu Trp Tyr Arg Thr Gly Asp Val Gly

435 440 445Val Met Glu Glu Asp Gly Phe Ile Arg Leu Val Ala Arg Ile Lys Glu

450 455 460Val Ile Ile Thr Gly Gly Phe Asn Val Tyr Pro Ala Glu Val Glu Glu465 470475 480Val Leu Ala Glu His Pro Asp Ile Glu Asp Ser Ala Val Val Gly Ile

485 490 495Pro Arg Glu Asp Gly Ser Glu Asn Val Val Ala Ala Ile Thr Leu Val

500 505 510Glu Gly Ala Ala Leu Asp Pro Asp Gly Leu Lys Glu Phe Ala Arg Lys

515 520 525Asn Leu Thr Arg Tyr Lys Val Pro Arg Thr Phe Tyr His Phe Glu Glu

530 535 540Met Pro Arg Asp Gln Met Gly Lys Ile Arg Arg Arg Glu Val Gln Ala545 550 555 560Glu Leu Leu Lys Lys Leu Gly Lys

565<210>31<211>411<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (388)<223>FRXA02487<400>31ggcgagtggt accgcaccgc gacgtcggag tgatgaagaa gccgggttca tccgcctagt 60tgctcgcatc aagaaagtca tcatcactgg cggtttcaac gtg tac cca gct gag 115

Val Tyr Pro Ala Glu

1 5gtt gaa gaa gtc ctc gca gag cac cca gac att gaa gat tcc gca gtc 163Val Glu Glu Val Leu Ala Glu His Pro Asp Ile Glu Asp Ser Ala Val

10 15 20gtt ggt atc ccg cgt gaa gac ggc tcc gaa aac gtc gtt gct gcc atc 211Val Gly Ile Pro Arg Glu Asp Gly Ser Glu Asn Val Val Ala Ala Ile

25 30 35act ttg gtg gaa ggt gca gcg ctg gat ccg gat ggc ctg aag gaa ttc 259Thr Leu Val Glu Gly Ala Ala Leu Asp Pro Asp Gly Leu Lys Glu Phe

40 45 50gcc cgc aag aac ctc acc cgc tac aag gttccg cgc act ttc tac cac 307Ala Arg Lys Asn Leu Thr Arg Tyr Lys Val Pro Arg Thr Phe Tyr His

55 60 65ttt gag gag atg ccg cgg gat cag atg ggc aag att agg cgt cgt gaa 355Phe Glu Glu Met Pro Arg Asp Gln Met Gly Lys Ile Arg Arg Arg Glu 70 75 80 85gtg cag gcg gag ttg ttg aag aag ctc ggc aag tagacgccga tttaagaggt 408Val Gln Ala Glu Leu Leu Lys Lys Leu Gly Lys

9095 cga 411<210>32<211>96<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>32Val Tyr Pro Ala Glu Val Glu Glu Val Leu Ala Glu His Pro Asp Ile 151015 Glu Asp Ser Ala Val Val Gly Ile Pro Arg Glu Asp Gly Ser Glu Asn

20 25 30Val Val Ala Ala Ile Thr Leu Val Glu Gly Ala Ala Leu Asp Pro Asp

35 40 45Gly Leu Lys Glu Phe Ala Arg Lys Asn Leu Thr Arg Tyr Lys Val Pro

50 55 60Arg Thr Phe Tyr His Phe Glu Glu Met Pro Arg Asp Gln Met Gly Lys 65 70 75 80Ile Arg Arg Arg Glu Val Gln Ala Glu Leu Leu Lys Lys Leu Gly Lys

859095<210>33<211>913<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (9l3)<223>FRXA02490<400>33tcatagctac gcgcatgccc acattctaga tcgccgaaga aagcagcggg acgtctctat 60atactaaagg gcactaaagc aacgcagttg aagggacacc atg tca gca tac gaa 115

Met Ser Ala Tyr Glu

1 5acc aaa gaa tgg ctc cag cac tac cca gag tgg acg cca cac tcg ctg 163Thr Lys Glu Trp Leu Gln His Tyr Pro Glu Trp Thr Pro His Ser Leu

10 15 20gaa tat ggc gac acc acc ctg ctg gac gtt tac gac aac aac ctg gcc 211Glu Tyr Gly Asp Thr Thr Leu Leu Asp Val Tyr Asp Asn Asn Leu Ala

25 30 35att aac gca gac aag cca gcc acc tac ttt ttc ggt cgt tca caa acc 259Ile Asn Ala Asp Lys Pro Ala Thr Tyr Phe Phe Gly Arg Ser Gln Thr

40 45 50tac ggt gaa ctg gac aaa gaa gtc cgc aaa act gcc gct ggc ctg cgc 307Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr Ala Ala Gly Leu Arg

55 60 65gca cta ggt gtc cgc ccc ggc gat cac gta gcg att atc ctc ccc aac 355Ala Leu Gly Val Arg Pro Gly Asp His Val Ala Ile Ile Leu Pro Asn 70 75 80 85tgc cca cag cac atc gca gct ttc tac gca gtg ctg aaa ctc ggc gca 403Cys Pro Gln His Ile Ala Ala Phe Tyr Ala Val Leu Lys Leu Gly Ala

90 95 100gta gtc att gag cac aac ccg ctc tac acc gcc cac gaa ctg ctc gaa 451Val Val Ile Glu His Asn Pro Leu Tyr Thr Ala His Glu Leu Leu Glu

105 110 115ccc ttc aaa gac cac ggt gcc cgc gtt gcc atc gtc tgg gac aaa gcc 499Pro Phe Lys Asp His Gly Ala Arg Val Ala Ile Val Trp Asp Lys Ala

120 125 130tcc ccc acc gtc gaa cag cta cgt gga cag acc cag ttg gaa acc atc 547Ser Pro Thr Val Glu Gln Leu Arg Gly Gln Thr Gln Leu Glu Thr Ile

135 140 145gtg tcg gtc aac atg atc aac gcg atg cca cca ctc cag cgc cta gca 595Val Ser Val Asn Met Ile Asn Ala Met Pro Pro Leu Gln Arg Leu Ala150 155 160165ctt cgg ctc cca atc cct gca ctg cgc aag agc cgc gaa tcc ctc tcc 643Leu Arg Leu Pro Ile Pro Ala Leu Arg Lys Ser Arg Glu Ser Leu Ser

170 175 180ggc gca gcc ccc aac acc gtt cct ttt gaa acc ctg acc agc gca gca 691Gly Ala Ala Pro Asn Thr Val Pro Phe Glu Thr Leu Thr Sar Ala Ala

185 190 195atg ggc ggc gac ggc gac gac gta gtt tca gaa ccc acc gtg acc aaa 739Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu Pro Thr Val Thr Lys

200 205 210gaa tcc gtc gcg ctg atc ctc tac acc tcc ggc acc acc gga cgc ccc 787Glu Ser Val Ala Leu Ile Leu Tyr Thr Ser Gly Thr Thr Gly Arg Pro

215 220 225aag ggt gcc cag ctc acc cac gga aac ctg ttc tcc aat ctc ctc caa 835Lys Gly Ala Gln Leu Thr His Gly Asn Leu Phe Ser Asn Leu Leu Gln230 235 240 245gga aag cac tgg gtt cca ggt ctc gga gac aaa cca gaa cgc atg ctt 883Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys Pro Glu Arg Met Leu

250 255 260gca gcc cta cca atg ttc cac gca tac ggt 913Ala Ala Leu Pro Met Phe His Ala Tyr Gly

265270<210>34<211>271<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>34Met Ser Ala Tyr Glu Thr Lys Glu Trp Leu Gln His Tyr Pro Glu Trp 151015 Thr Pro His Ser Leu Glu Tyr Gly Asp Thr Thr Leu Leu Asp Val Tyr

20 25 30Asp Asn Asn Leu Ala Ile Asn Ala Asp Lys Pro Ala Thr Tyr Phe Phe

35 40 45Gly Arg Ser Gln Thr Tyr Gly Glu Leu Asp Lys Glu Val Arg Lys Thr

50 55 60Ala Ala Gly Leu Arg Ala Leu Gly Val Arg Pro Gly Asp His Val Ala 65 70 75 80Ile Ile Leu Pro Asn Cys Pro Gln His Ile Ala Ala Phe Tyr Ala Val

85 90 95Leu Lys Leu Gly Ala Val Val Ile Glu His Asn Pro Leu Tyr Thr Ala

100 105 110His Glu Leu Leu Glu Pro Phe Lys Asp His Gly Ala Arg Val Ala Ile

115 120 125Val Trp Asp Lys Ala Ser Pro Thr Val Glu Gln Leu Arg Gly Gln Thr

130 135 140Gln Leu Glu Thr Ile Val Ser Val Asn Met Ile Asn Ala Met Pro Pro145 150 155 160Leu Gln Arg Leu Ala Leu Arg Leu Pro Ile Pro Ala Leu Arg Lys Ser

165 170 175Arg Glu Ser Leu Ser Gly Ala Ala Pro Asn Thr Val Pro Phe Glu Thr

180 185 190Leu Thr Ser Ala Ala Met Gly Gly Asp Gly Asp Asp Val Val Ser Glu

195 200 205Pro Thr Val Thr Lys Glu Ser Val Ala Leu Ile Leu Tyr Thr Ser Gly

210 215 220Thr Thr Gly Arg Pro Lys Gly Ala Gln Leu Thr His Gly Asn Leu Phe225 230 235 240Ser Asn Leu Leu Gln Gly Lys His Trp Val Pro Gly Leu Gly Asp Lys

245 250 255Pro Glu Arg Met Leu Ala Ala Leu Pro Met Phe His Ala Tyr Gly

260265270<210>35<211>414<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (391)<223>RXA01467<400>35gcgtcatctt tagccttgct ttatgagctt ttccccgcaa tgagccgcgt tgtgtatcca 60taagtcttag cctacaagcg ctttgaggta gtttgggatc atg gat ttc aac gac 115

Met Asp Phe Asn Asp

1 5aaa gcc gct tca gaa aac gct gta aag act ggc gca gaa ggc ccc aac 163Lys Ala Ala Ser Glu Asn Ala Val Lys Thr Gly Ala Glu Gly Pro Asn

10 15 20gtt ttc gcg agc gtg gcc aag att ttg cag gat gtt ggc gga att tca 211Val Phe Ala Ser Val Ala Lys Ile Leu Gln Asp Val Gly Gly Ile Ser

25 30 35gcc gaa gac gtc act ccg gaa tct cgt ttt act gag gat ttg gca gtg 259Ala Glu Asp Val Thr Pro Glu Ser Arg Phe Thr Glu Asp Leu Ala Val

40 45 50agc tca ctc aat tac atc gag ttg att gtc aat gcg gag gac gca ttt 307Ser Ser Leu Asn Tyr Ile Glu Leu Ile Val Asn Ala Glu Asp Ala Phe

55 60 65ggt gtt cgc att gag gac gcc gat gcc aag gat ttg acc acc gtg cag 355Gly Val Arg Ile Glu Asp Ala Asp Ala Lys Asp Leu Thr Thr Val Gln 70 75 80 85gat ttg att gac ttt att aac acc aat aag gct gat tagcgggaaa 401Asp Leu Ile Asp Phe Ile Asn Thr Asn Lys Ala Asp

9095 atttcgccca aaa 414<210>36<211>97<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>36Met Asp Phe Asn Asp Lys Ala Ala Ser Glu Asn Ala Val Lys Thr Gly 151015 Ala Glu Gly Pro Asn Val Phe Ala Ser Val Ala Lys Ile Leu Gln Asp

20 25 30Val Gly Gly Ile Ser Ala Glu Asp Val ThrPro Glu Ser Arg Phe Thr

35 40 45Glu Asp Leu Ala Val Sar Ser Leu Asn Tyr Ile Glu Leu Ile Val Asn

50 55 60Ala Glu Asp Ala Phe Gly Val Arg Ile Glu Asp Ala Asp Ala Lys Asp 65 70 75 80Leu Thr Thr Val Gln Asp Leu Ile Asp Phe Ile Asn Thr Asn Lys Ala

859095 Asp<210>37<211>298<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (298)<223>RXA00796<400>37ctggaatccc aaagcgcttg catgacgcgg aaagttaaca taggctaggt acgtcaagtt 60gttgatacat caacttaatt aacttttaga ggagtacacc atg agc aag atc gcc 115

Met Ser Lys Ile Ala

1 5atc atc acc ggt tcc acc cgt cca ggc cgc gtc aac att gac gta gcc 163Ile Ile Thr Gly Ser Thr Arg Pro Gly Arg Val Asn Ile Asp Val Ala

10 15 20aac tgg gtt ctc gag cgc gca caa gag cgc aac gat gca cag tac gag 211Asn Trp Val Leu Glu Arg Ala Gln Glu Arg Asn Asp Ala Gln Tyr Glu

25 30 35ctc gtt gat atc gcc gat ttc aac ttc ccc gtc ctc gac gaa gca atg 259Leu Val Asp Ile Ala Asp Phe Asn Phe Pro Val Leu Asp Glu Ala Met

40 45 50cca gcc ggc tac ggc cag tat gca aac gag cac acc aag 298Pro Ala Gly Tyr Gly Gln Tyr Ala Asn Glu His Thr Lys

556065<210>38<211>66<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>38Met Ser Lys Ile Ala Ile Ile Thr Gly Ser Thr Arg Pro Gly Arg Val 151015 AsnIle Asp Val Ala Asn Trp Val Leu Glu Arg Ala Gln Glu Arg Asn

20 25 30Asp Ala Gln Tyr Glu Leu Val Asp Ile Ala Asp Phe Asn Phe Pro Val

35 40 45Leu Asp Glu Ala Met Pro Ala Gly Tyr Gly Gln Tyr Ala Asn Glu His

505560 Thr Lys 65<210>39<211>666<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).)

Met Lys Ile Gly Val

1 5atc ctg ggc agt atc cgc gaa ggc cgc ttc ggc caa ggc gtt gcc gat 163Ile Leu Gly Ser Ile Arg Glu Gly Arg Phe Gly Gln Gly Val Ala Asp

10 15 20tgg gtc atg gaa caa atc ggg gct tat gac gca ccc gat gtg gaa ttt 211Trp Val Met Glu Gln Ile Gly Ala Tyr Asp Ala Pro Asp Val Glu Phe

25 30 35gaa ctc atc gac ctc aaa gct ttc aac gtg ccc ctg ttg gaa tcc gcg 259Glu Leu Ile Asp Leu Lys Ala Phe Asn Val Pro Leu Leu Glu Ser Ala

40 45 50aca gtt cca ggt tcc gcg gat aaa cag tac gac gac ccg cgc gta act 307Thr Val Pro Gly Ser Ala Asp Lys Gln Tyr Asp Asp Pro Arg Val Thr

55 60 65gcc tgg tca cag gcc att gat gcc tgc gat gcc ttc ctt ttc atc acc 355Ala Trp Ser Gln Ala Ile Asp Ala Cys Asp Ala Phe Leu Phe Ile Thr 70 75 80 85ccg gaa tac aac cac ggt gtg ccc ggc gcg ttc aaa aat gcg tat gac 403Pro Glu Tyr Asn His Gly Val Pro Gly Ala Phe Lys Asn Ala Tyr Asp

90 95100atc ctg ggc aat gaa tgg ctg aac aaa acc gtc ggt ttc att tcc tac 451Ile Leu Gly Asn Glu Trp Leu Asn Lys Thr Val Gly Phe Ile Ser Tyr

105 110 115ggt gca gtc gaa ggg atc cgt gtt gtc gaa cag tgg cgt cag atc gtc 499Gly Ala Val Glu Gly Ile Arg Val Val Glu Gln Trp Arg Gln Ile Val

120 125 130gcc acc ttc aac atg tac gat atc cgc agc cag cta tcc ttt tcc acc 547Ala Thr Phe Asn Met Tyr Asp Ile Arg Ser Gln Leu Ser Phe Ser Thr

135 140 145ttc acc gag aac aac aac ggc act ttt gcg ccc aat gat cga cgc ccc 595Phe Thr Glu Asn Asn Asn Gly Thr Phe Ala Pro Asn Asp Arg Arg Pro150 155 160 165ggt gaa cta atc cgc ctc ctt gat agc ctc cta acg gct gtc cgc gat 643Gly Glu Leu Ile Arg Leu Leu Asp Ser Leu Leu Thr Ala Val Arg Asp

170175180 taaggctctg aaatactaat gag 666<210>40<211>181<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>40Met Lys Ile Gly Val Ile Leu Gly Ser Ile Arg Glu Gly Arg Phe Gly 151015 Gln Gly Val Ala Asp Trp Val Met Glu Gln Ile Gly Ala Tyr Asp Ala

20 25 30Pro Asp Val Glu Phe Glu Leu Ile Asp Leu Lys Ala Phe Asn Val Pro

35 40 45Leu Leu Glu Ser Ala Thr Val Pro Gly Ser Ala Asp Lys Gln Tyr Asp

50 55 60Asp Pro Arg Val Thr Ala Trp Ser Gln Ala Ile Asp Ala Cys Asp Ala 65 70 75 80Phe Leu Phe Ile Thr Pro Glu Tyr Asn His Gly Val Pro Gly Ala Phe

85 90 95Lys Asn Ala Tyr Asp Ile Leu Gly Asn Glu TrpLeu Asn Lys Thr Val

100 105 110Gly Phe Ile Ser Tyr Gly Ala Val Glu Gly Ile Arg Val Val Glu Gln

115 120 125Trp Arg Gln Ile Val Ala Thr Phe Asn Met Tyr Asp Ile Arg Ser Gln

130 135 140Leu Ser Phe Ser Thr Phe Thr Glu Asn Asn Asn Gly Thr Phe Ala Pro145 150 155 160Asn Asp Arg Arg Pro Gly Glu Leu Ile Arg Leu Leu Asp Ser Leu Leu

165 170 175Thr Ala Val Arg Asp

180<210>41<211>375<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (375)<223>RXN02809<400>41aac ctc tcc gtc cca gca gca cta acc aac gcc ctt tcc tac ctc tcc 48Asn Leu Ser Val Pro Ala Ala Leu Thr Asn Ala Leu Ser Tyr Leu Ser 151015 gca gag tgg aac aac aag gct gca ggc atc gtc tcc tac ggc tcc gca 96Ala Glu Trp Asn Asn Lys Ala Ala Gly Ile Val Ser Tyr Gly Ser Ala

20 25 30atg ggc gtt cgc gca gct gag cac ctc cgc ggc atc ctt tcc gag ctt 144Met Gly Val Arg Ala Ala Glu His Leu Arg Gly Ile Leu Ser Glu Leu

35 40 45cag atc gca cac gtt caa aag acc ggc ctg ctg agc atc ttc acc gac 192Gln Ile Ala His Val Gln Lys Thr Gly Leu Leu Ser Ile Phe Thr Asp

50 55 60ttc gaa tac cct aac ttc aag cct tcc gag cag ggc atc tcc tct gtg 240Phe Glu Tyr Pro Asn Phe Lys Pro Ser Glu Gln Gly Ile Ser Ser Val 65 70 75 80gac gct atg ctt gag cag ctt gtt gtc tgg acc aag gca atg tcc acc 288Asp Ala Met Leu Glu Gln Leu Val Val Trp ThrLys Ala Met Ser Thr

85 90 95att cgc gag tct gcg aac gtc tat cac tta aga acc cct cac aaa agt 336Ile Arg Glu Ser Ala Asn Val Tyr His Leu Arg Thr Pro His Lys Ser

100 105 110ggc gag ctc ccc gac tgg gac tcg cct ctt ttc gta ttc 375Gly Glu Leu Pro Asp Trp Asp Ser Pro Leu Phe Val Phe

115120125<210>42<211>125<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>42Asn Leu Ser Val Pro Ala Ala Leu Thr Asn Ala Leu Ser Tyr Leu Ser 151015 Ala Glu Trp Asn Asn Lys Ala Ala Gly Ile Val Ser Tyr Gly Ser Ala

20 25 30Met Gly Val Arg Ala Ala Glu His Leu Arg Gly Ile Leu Ser Glu Leu

35 40 45Gln Ile Ala His Val Gln Lys Thr Gly Leu Leu Ser Ile Phe Thr Asp

50 55 60Phe Glu Tyr Pro Asn Phe Lys Pro Ser Glu Gln Gly Ile Ser Ser Val 65 70 75 80Asp Ala Met Leu Glu Gln Leu Val Val Trp Thr Lys Ala Met Ser Thr

85 90 95Ile Arg Glu Ser Ala Asn Val Tyr His Leu Arg Thr Pro His Lys Ser

100 105 110Gly Glu Leu Pro Asp Trp Asp Ser Pro Leu Phe Val Phe

115120125<210>43<211>273<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (273)<223>FRXA02809<400>43gca gca cta acc aac gcc ctt tcc tac ctc tcc gca gag tgg aac aac 48Ala Ala Leu Thr Asn Ala Leu Ser Tyr Leu Ser Ala Glu Trp Asn Asn 151015 aag gct gca ggc atc gtc tcc tac ggctcc gca atg ggc gtt cgc gca 96Lys Ala Ala Gly Ile Val Ser Tyr Gly Ser Ala Met Gly Val Arg Ala

20 25 30gct gag cac ctc cgc ggc atc ctt tcc gag ctt cag atc gca cac gtt 144Ala Glu His Leu Arg Gly Ile Leu Ser Glu Leu Gln Ile Ala His Val

35 40 45caa aag acc ggc ctg ctg agc atc ttc acc gac ttc gaa tac cct aac 192Gln Lys Thr Gly Leu Leu Ser Ile Phe Thr Asp Phe Glu Tyr Pro Asn

50 55 60ttc aag cct tcc gag cag ggc atc tcc tct gtg gac gct atg ctt gag 240Phe Lys Pro Ser Glu Gln Gly Ile Ser Ser Val Asp Ala Met Leu Glu 65 70 75 80cag ctt gtt gtc tgg acc aag gca atg tcc acc 273Gln Leu Val Val Trp Thr Lys Ala Met Ser Thr

8590<210>44<211>91<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>44Ala Ala Leu Thr Asn Ala Leu Ser Tyr Leu Ser Ala Glu Trp Asn Asn 151015 Lys Ala Ala Gly Ile Val Ser Tyr Gly Ser Ala Met Gly Val Arg Ala

20 25 30Ala Glu His Leu Arg Gly Ile Leu Ser Glu Leu Gln Ile Ala His Val

35 40 45Gln Lys Thr Gly Leu Leu Ser Ile Phe Thr Asp Phe Glu Tyr Pro Asn

50 55 60Phe Lys Pro Ser Glu Gln Gly Ile Ser Ser Val Asp Ala Met Leu Glu 65 70 75 80Gln Leu Val Val Trp Thr Lys Ala Met Ser Thr

8590<210>45<211>5745<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><22l>CDS<222>(101) }, (5722)<223>RXN00113<400>45tctgcgcatc ccactcgagg agctggcaaa cggccgcacc atcgatgttg aggcacgcac 60cgactccatc gaagagtccg catccggccg tatcgttacc gtg cgc atc gtg ctc 115

Val Arg Ile Val Leu

1 5acc acc gaa ggc gaa gta gca gcc aag ctg gtt acc cgc ttc gca att 163Thr Thr Glu Gly Glu Val Ala Ala Lys Leu Val Thr Arg Phe Ala Ile

10 15 20cgt gga cgc atc acc acc aac gaa atg gct gca cca gca gat tcc tac 211Arg Gly Arg Ile Thr Thr Asn Glu Met Ala Ala Pro Ala Asp Ser Tyr

25 30 35ggc gca cgc gac gaa gtt gtc gag gca acc cct cgt tcc ttc atc cgc 259Gly Ala Arg Asp Glu Val Val Glu Ala Thr Pro Arg Ser Phe Ile Arg

40 45 50cag gca act gtt tct gca cct gca gac atg acc cca ttc gcc atg gtt 307Gln Ala Thr Val Ser Ala Pro Ala Asp Met Thr Pro Phe Ala Met Val

55 60 65tct ggt gac tac aac cca att cac acc tct gac aac gct gca aag ctt 355Ser Gly Asp Tyr Asn Pro Ile His Thr Ser Asp Asn Ala Ala Lys Leu 70 75 80 85gtt ggc ctg gac gca gct ctt gtc cac ggc atg tgg ctg tcc gct acc 403Val Gly Leu Asp Ala Ala Leu Val His Gly Met Trp Leu Ser Ala Thr

90 95 100gca cag cac ctc gct ggt ctt ggc tct gag gtc att ggt tgg acc tac 451Ala Gln His Leu Ala Gly Leu Gly Ser Glu Val Ile Gly Trp Thr Tyr

105 110 115tcc atg tac ggc atg gtt caa ctc aac gac gtt gtt gac atc acc gtc 499Ser Met Tyr Gly Met Val Gln Leu Asn Asp Val Val Asp Ile Thr Val

120 125 130gag cgt gtt ggc cgc gca ggt ctg aag cct gca tac gag gtc acc tgc 547Glu Arg Val Gly Arg Ala Gly Leu Lys Pro Ala Tyr Glu Val Thr Cys

135 140 145cgc att gat ggc aac gtt gtc tcc cgc gga cag gca ctg ctc aag gct 595Arg Ile Asp Gly Asn Val Val Ser Arg Gly Gln Ala Leu Leu Lys Ala150 155 160 165cct tcc acc gct tat gtt tac cca agc cag ggc atc cag gct aag ggc 643Pro Ser Thr Ala Tyr Val Tyr Pro Ser Gln Gly Ile Gln Ala Lys Gly

170 175 180atg ggc caa ggc gat cgc acc gca agc gca gag gct cgc gct gtg tgg 691Met Gly Gln Gly Asp Arg Thr Ala Ser Ala Glu Ala Arg Ala Val Trp

185 190 195gag cgt gca gat gca cac acc cgc gca aac ctg ggc ttc tcc atc cag 739Glu Arg Ala Asp Ala His Thr Arg Ala Asn Leu Gly Phe Ser Ile Gln

200 205 210cag gtc att gat gaa aac cca act gag ctg aag gtc ggg gac acc acc 787Gln Val Ile Asp Glu Asn Pro Thr Glu Leu Lys Val Gly Asp Thr Thr

215 220 225ttc gtg cac cca gct ggg gtt ttg aac ctc acc cag ttc acg cag gtc 835Phe Val His Pro Ala Gly Val Leu Asn Leu Thr Gln Phe Thr Gln Val230 235 240 245gcg ctc gcc gtg gtt gcc tac gct cag acc gag cgc ctc aag gct gca 883Ala Leu Ala Val Val Ala Tyr Ala Gln Thr Glu Arg Leu Lys Ala Ala

250 255 260aac gca att gtc gac ggc tcc ctc tac gca ggc cac tcc ctc ggc gag 931Asn Ala Ile Val Asp Gly Ser Leu Tyr Ala Gly His Ser Leu Gly Glu

265 270 275tac acc gca ctg gca tcc ttg ggc aac atc ttc gaa ctc gaa ggc gtc 979Tyr Thr Ala Leu Ala Ser Leu Gly Asn Ile Phe Glu Leu Glu Gly Val

280 285 290atc gac gtt gtg ttc tcc cgc ggt tcc gca atg cac tcc ctg gtt cca 1027Ile Asp Val Val Phe Ser Arg Gly Ser Ala Met His Ser Leu Val Pro

295 300 305cgt gat gag aag ggc cgt tcc aac tac ggt ctt gcc gca ttc cgt ccg 1075Arg Asp Glu Lys Gly Arg Ser Asn Tyr Gly Leu Ala Ala Phe Arg Pro310 315 320 325aac atg atc aac gtt gca gcc acc gag gtg gag aac tgg gtt gac cgt 1123Asn Met Ile Asn Val Ala Ala Thr Glu Val Glu Asn Trp Val Asp Arg

330 335 340gtc gct gaa gaa tcc ggc gaa ttc ctg cag atc gtt aac tac aac gtt 1171Val Ala Glu Glu Ser Gly Glu Phe Leu Gln Ile Val Asn Tyr Asn Val

345 350 355gat ggc cag cag tac gca gtc gca ggt acc ttg gct ggc ctg aag gcc 1219Asp Gly Gln Gln Tyr Ala Val Ala Gly Thr Leu Ala Gly Leu Lys Ala

360 365 370ctc aag gct tct gca tct gca aac cca cgt gct tac gtg aac att cca 1267Leu Lys Ala Ser Ala Ser Ala Asn Pro Arg Ala Tyr Val Asn Ile Pro

375 380 385ggc att gac gtg cca ttc cac tcc agc gtc ctg cgc cca ggc gtt cct 1315Gly Ile Asp Val Pro Phe His Ser Ser Val Leu Arg Pro Gly Val Pro390 395 400 405gct ttc gca gag aag ctg gac gag ctg ctg cca gag acc atc gac att 1363Ala Phe Ala Glu Lys Leu Asp Glu Leu Leu Pro Glu Thr Ile Asp Ile

410 415 420gat gct ctt cgc ggc cgc tac atc ccg aac ctg gtt gct cgt cct ttc 1411Asp Ala Leu Arg Gly Arg Tyr Ile Pro Asn Leu Val Ala Arg Pro Phe

425 430 435gag ctc acc cag agc ttc gtggat gcc atc ctt gct gtt gtt cca tcc 1459Glu Leu Thr Gln Ser Phe Val Asp Ala Ile Leu Ala Val Val Pro Ser

440 445 450gag cgc ctc aag ggc atc aag gtg gag gac acc gac gag aac acc ctg 1507Glu Arg Leu Lys Gly Ile Lys Val Glu Asp Thr Asp Glu Asn Thr Leu

455 460 465gca cgt ctg ctc ctc atc gag ctg ctg tct tgg cag ttc gca tcc cct 1555Ala Arg Leu Leu Leu Ile Glu Leu Leu Ser Trp Gln Phe Ala Ser Pro470 475 480 485gtg cgt tgg atc gaa acc cag gct ctg atc atc gat acc gtc gat cag 1603Val Arg Trp Ile Glu Thr Gln Ala Leu Ile Ile Asp Thr Val Asp Gln

490 495 500atc atc gag gtc ggc ttg gca gca tcg cca acc ctg acc aac ctg gca 1651Ile Ile Glu Val Gly Leu Ala Ala Ser Pro Thr Leu Thr Asn Leu Ala

505 510 515ctg cgc acc atg gat gtc att ggc aag tcc cgc cca gta ttc aac gtg 1699Leu Arg Thr Met Asp Val Ile Gly Lys Ser Arg Pro Val Phe Asn Val

520 525 530gag cgc gac cag gac acc gtt atg ctc aac gat gtt cgc cag gca cct 1747Glu Arg Asp Gln Asp Thr Val Met Leu Asn Asp Val Arg Gln Ala Pro

535 540 545gtt gct gag gtt gaa gaa gaa gca gtt gag gaa gca cct gca gca gcc 1795Val Ala Glu Val Glu Glu Glu Ala Val Glu Glu Ala Pro Ala Ala Ala550 555 560 565gca gct cca gca gct gag gca cca gtt gct gca gct cca gta gcc gca 1843Ala Ala Pro Ala Ala Glu Ala Pro Val Ala Ala Ala Pro Val Ala Ala

570 575 580gcc gca cct gca cct gtt gga aac gca cct gaa ctg aag ttc aac gct 1891Ala Ala Pro Ala Pro Val Gly Asn Ala Pro Glu Leu Lys Phe Asn Ala

585 590 595gcc aat gcc atc atg gtt ctc ttc gct gtc cag aac aag arc aac att 1939Ala Asn Ala Ile Met Val Leu Phe Ala Val Gln Asn Lys Ile Asn Ile

600 605 610gat cag arc acc gca gcg gat acc tct gag acc ctg acc aac ggt gtg 1987Asp Gln Ile Thr Ala Ala Asp Thr Ser Glu Thr Leu Thr Asn Gly Val

615 620 625tcc tca cgc cgt aac cag atg ctc atg gac atg tcc acc gag ctg tcc 2035Ser Ser Arg Arg Asn Gln Met Leu Met Asp Met Ser Thr Glu Leu Ser630 635 640 645gtc cca acc atc gac ggc gca gct gac gct gac gta gct acc ctg cag 2083Val Pro Thr Ile Asp Gly Ala Ala Asp Ala Asp Val Ala Thr Leu Gln

650 655 660gga cgt gtt gtc acc gca gct cct ggc tac aag cct ttc gga cca gtt 2131Gly Arg Val Val Thr Ala Ala Pro Gly Tyr Lys Pro Phe Gly Pro Val

665 670 675ctt tcc gag acc gtt cgt gca cgt ctt cgc gca ctg acc ggt gca gca 2179Leu Ser Glu Thr Val Arg Ala Arg Leu Arg Ala Leu Thr Gly Ala Ala

680 685 690ggt ctg aag acc tcc tac atc ggc gat cgc gtg acc ggc acc tgg gga 2227Gly Leu Lys Thr Ser Tyr Ile Gly Asp Arg Val Thr Gly Thr Trp Gly

695 700 705ctt cca gaa agc tgg acc gca cac gtt gag gtt gaa ttg ctg ctg ggc 2275Leu Pro Glu Ser Trp Thr Ala His Val Glu Val Glu Leu Leu Leu Gly710 715 720 725acc cgc gaa ggc gag tcc gtc cgc ggc ggc aac ctg ggt agc ctg cct 2323Thr Arg Glu Gly Glu Ser Val Arg Gly Gly Asn Leu Gly Ser Leu Pro

730 735 740gct aac gca tcc agc aag ggc gac gtc gat gcg ctt atc gac gca gcc 2371Ala Asn Ala Ser Ser Lys Gly Asp Val Asp Ala Leu Ile Asp Ala Ala

745 750 755gtg cag aat gtt gct gca gcc aac ggc acc agc gtc tcc atg tcc tcc 2419Val Gln Asn Val Ala Ala Ala Asn Gly Thr Ser Val Ser Met Ser Ser

760 765 770ggc ggt gca gct tca ggt ggc gga gtt gtt gat tcc gca gca ctt gat 2467Gly Gly Ala Ala Ser Gly Gly Gly Val Val Asp Ser Ala Ala Leu Asp

775 780 785gcc tac gca tcc acc gtc act ggt gaa gaa ggc gtc ctg gca aac gtt 2515

Ala Tyr Ala Ser Thr Val Thr Gly Glu Glu Gly Val Leu Ala Asn Val790 795 800 805gct cgc ggc atc ctg tct cag ctt ggt ctc gac acc aag gac gag gtt 2563Ala Arg Gly Ile Leu Ser Gln Leu Gly Leu Asp Thr Lys Asp Glu Val

810 815 820gaa ggc gca gag atc gac acc gaa ctc tac gac gct gtc gaa gca gaa 2611Glu Gly Ala Glu Ile Asp Thr Glu Leu Tyr Asp Ala Val Glu Ala Glu

825 830 835ctg ggc acc ggc tgg ctg aag ctt gtc acc cca gtg ttc tcc gct gat 2659Leu Gly Thr Gly Trp Leu Lys Leu Val Thr Pro Val Phe Ser Ala Asp

840 845 850cgt gcg atc ttg ttc gac gac cgt tgg gca tct gca cgt gaa gat ctg 2707Arg Ala Ile Leu Phe Asp Asp Arg Trp Ala Ser Ala Arg Glu Asp Leu

855 860 865gca cgc ctt gcc aac ggc gag gat att gcc gtc gag cgc ttt gct gga 2755Ala Arg Leu Ala Asn Gly Glu Asp Ile Ala Val Glu Arg Phe Ala Gly870 875 880 885acg ggg gag acc gtc gtc aag caa gct gca tgg tgg gct gag cac gtt 2803Thr Gly Glu Thr Val Val Lys Gln Ala Ala TrpTrp Ala Glu His Val

890 895 900gaa gac acc gct ctc gct gca acc ctg aag cag gtt tcc gag gtg gct 2851Glu Asp Thr Ala Leu Ala Ala Thr Leu Lys Gln Val Ser Glu Val Ala

905 910 915gcg aag cca gcc aac gag cca cac atc gac gat gtt gcg ctg gtt acc 2899Ala Lys Pro Ala Asn Glu Pro His Ile Asp Asp Val Ala Leu Val Thr

920 925 930ggt gcg gct cct gag tcg atc gcc ggt gca gtt gcg gct cgc ctg ctg 2947Gly Ala Ala Pro Glu Ser Ile Ala Gly Ala Val Ala Ala Arg Leu Leu

935 940 945tcc cag ggc gcg acc gtc att ctc acc gca tcg aac gtc tcc cag gcg 2995Ser Gln Gly Ala Thr Val Ile Leu Thr Ala Ser Asn Val Ser Gln Ala950 955 960 965cgt aag gaa tac gca cgc aag ctc tac gct gcg aac gca acc cct aac 3043Arg Lys Glu Tyr Ala Arg Lys Leu Tyr Ala Ala Asn Ala Thr Pro Asn

970 975 980gca aag ctg tgg att gtt cct gcg aac atg tcc tcc tac cgc gat gtt 3091Ala Lys Leu Trp Ile Val Pro Ala Asn Met Ser Ser Tyr Arg Asp Val

985 990 995gat gca gtc atc gat tgg atc ggc aac gag cag cgc gtc acc gtc ggc 3139Asp Ala Val Ile Asp Trp Ile Gly Asn Glu Gln Arg Val Thr Val Gly

1000 1005 1010agc acc gtc acc gtg acc aag cca gct ctg acc cca acc ctt gcg tac 3187Ser Thr Val Thr Val Thr Lys Pro Ala Leu Thr Pro Thr Leu Ala Tyr

1015 1020 1025cca ttc gca gct cca tcc gta tcc ggt acc ttg gcg gat gca ggc cca 3235Pro Phe Ala Ala Pro Ser Val Ser Gly Thr Leu Ala Asp Ala Gly Pro1030 1035 1040 1045cag gct gaa aac cag gca cgc ctg ctc ctc tgg tcc gtg gag cgc acc 3283Gln Ala Glu Asn Gln Ala Arg Leu Leu Leu Trp Ser Val Glu Arg Thr

1050 1055 1060atc gca gga ctt gca gat ctt gca tcc cgc ggt gtc gat gga cgc gtc 3331Ile Ala Gly Leu Ala Asp Leu Ala Ser Arg Gly Val Asp Gly Arg Val

1065 1070 1075cac gtt gta ctc cca ggt tcc ccg aac cgc gga atg ttc ggt ggc gac 3379His Val Val Leu Pro Gly Ser Pro Asn Arg Gly Met Phe Gly Gly Asp

1080 1085 1090ggc gct tac ggc gaa gtc aag gct gct ttc gac gcc atc ctt gcc aag 3427Gly Ala Tyr Gly Glu Val Lys Ala Ala Phe Asp Ala Ile Leu Ala Lys

1095 1100 1105tgg ggc tcc gag acc ggc tgg cca cag ttt gtc tcc ctc gca cag gca 3475Trp Gly Ser Glu Thr Gly Trp Pro Gln Phc Val Ser Leu Ala Gln Ala1110 1115 1120 1125cgc atc ggc tgg gtc gca ggc acc ggc ctc atg ggt cgc aac gac gtg 3523Arg Ile Gly Trp Val Ala Gly Thr Gly Leu Met Gly Arg Asn Asp Val

1130 1135 1140ctc atc cct gcc gct gaa aag ctg ggc atc cac gtc tac acc cct gaa 3571Leu Ile Pro Ala Ala Glu Lys Leu Gly Ile His Val Tyr Thr Pro Glu

1145 1150 1155gag atc tct tcc gaa ctg ctg ggt ctt gca tcc gca gaa tcc cgc gaa 3619Glu Ile Ser Ser Glu Leu Leu Gly Leu Ala Ser Ala Glu Ser Arg Glu

1160 1165 1170aag gct ctg gaa gca ccg atc gat tac gac ctg acc ggt gga ctt tcc 3667Lys Als Leu Glu Ala Pro Ile Asp Tyr Asp Leu Thr Gly Gly Leu Ser

1175 1180 1185ggt ggc gta tcc atc gca gca ctg gca gca tcc ctc gag tcc gac gca 3715Gly Gly Val Ser Ile Ala Ala Leu Ala Ala Ser Leu Glu Ser Asp Ala1190 1195 1200 1205gta gag acc acc tct gca gca gaa gac acc atc aag gcg ctt cca tca 3763Val Glu Thr Thr Ser Ala Ala Glu Asp Thr Ile Lys Ala Leu Pro Ser

1210 1215 1220cct aag cac cca gag cag cca gtg ggc acg cca gtt gga gag gtc aag 3811Pro Lys His Pro Glu Gln Pro Val Gly Thr Pro Val Gly Glu Val Lys

1225 1230 1235acc gat ctc gaa gac atg gtt gtc atg gtt ggc gtt ggc gaa gtc tcc 3859Thr Asp Leu Glu Asp Met Val Val Met Val Gly Val Gly Glu Val Ser

1240 1245 1250tca tgg ggc tcc gga cgt acc cgc ttc gaa gct gag tac ggc atc cag 3907Ser Trp Gly Ser Gly Arg Thr Arg Phe Glu Ala Glu Tyr Gly Ile Gln

1255 1260 1265cgc gac ggc tcc gtt gac ctc acc gca gca ggc gtc ctt gag ctt gca 3955Arg Asp Gly Ser Val Asp Leu Thr Ala Ala Gly Val Leu Glu Leu Ala1270 1275 1280 1285tgg atg atg ggt ctg atc tcc tgg agc gaa gat cca aag cca gcc tgg 4003Trp Met Met Gly Leu Ile Ser Trp Ser Glu Asp Pro Lys Pro Ala Trp

1290 1295 1300tac gac gct gac ggc acc gaa gtg cct gaa gaa gag atc tac gag cgc 4051Tyr Asp Ala Asp Gly Thr Glu Val Pro Glu Glu Glu Ile Tyr Glu Arg

1305 1310 1315ttc cgc gac gaa gtc atc gca cga tgc ggt gtt cgt gag ctt gtc gac 4099Phe Arg Asp Glu Val Ile Ala Arg Cys Gly Val Arg Glu Leu Val Asp

1320 1325 1330gac gca ttc ctc gtc gac ggc ggc tcc ctc gac gca gct gaa gtc ttc 4147Asp Ala Phe Leu Val Asp Gly Gly Ser Leu Asp Ala Ala Glu Val Phc

1335 1340 1345ctc gac cgc gac atc tcc ttc tcc gta acc tct gct gaa gaa gca cag 4195Leu Asp Arg Asp Ile Ser Phe Ser Val Thr Ser Ala Glu Glu Ala Gln1350 1355 1360 1365gcc tac gtc gat gca gat gct tcc gtg acc gtt gaa gaa gca gac ggc 4243Ala Tyr Val Asp Ala Asp Ala Ser Val Thr Val Glu Glu Ala Asp Gly

1370 1375 1380gaa tgg atc gtg acc aag aag aag ggc tcc acc tcc ttc gtg cca cgc 4291Glu Trp Ile Val Thr Lys Lys Lys Gly Ser Thr Ser Phe Val Pro Arg

1385 1390 1395aag gca acc ctg acc cgc tcc gta gca ggc cag ctg cca acc gac ttc 4339Lys Ala Thr Leu Thr Arg Ser Val Ala Gly Gln Leu Pro Thr Asp Phe

1400 1405 1410gac cct gcc aag tgg ggt atc cca gcc tcc atg atc gat gca ctc gac 4387Asp Pro Ala Lys Trp Gly Ile Pro Ala Ser Met Ile Asp Ala Leu Asp

1415 1420 1425aac atc gca gcg tgg aac ctg gtc act gca gtc gac gcc ttc ctg tcc 4435Asn Ile Ala Ala Trp Asn Leu Val Thr Ala Val Asp Ala Phe Leu Ser1430 1435 1440 1445tcc ggc ttc agc cca gca gaa ctc ctg cag tcc atc cac cca gct gac 4483Ser Gly Phe Ser Pro Ala Glu Leu Leu Gln Ser Ile His Pro Ala Asp

1450 1455 1460gtg tcc tcc acc cag ggc acc ggt atc ggt ggc atg cag tcc cta cgc 4531Val Ser Ser Thr Gln Gly Thr Gly Ile Gly Gly Met Gln Ser Leu Arg

1465 1470 1475aag ctg ttc gtc aac cgc ttc ctc ggc cag gat cgt cca tcc gac atc 4579Lys Leu Phe Val Asn Arg Phe Leu Gly Gln Asp Arg Pro Ser Asp Ile

1480 1485 1490ctc cag gag acc ctg cca aac gtt gtg gct gca cac acc atg cag tcc 4627Leu Gln Glu Thr Leu Pro Asn Val Val AlaAla His Thr Met Gln Ser

1495 1500 1505tac gtc ggt ggc tac ggc cag atg atc cac cca gtg gca gca tgt gca 4675Tyr Val Gly Gly Tyr Gly Gln Met Ile His Pro Val Ala Ala Cys Ala1510 1515 1520 1525acc gca gct gtc tcc gtg gaa gaa ggc gtg gac aag atc cgc ctc aac 4723Thr Ala Ala Val Ser Val Glu Glu Gly Val Asp Lys Ile Arg Leu Asn

1530 1535 1540aag gca gat ttc gtt gtc gcc ggt ggt atc gat gac atc cag gtt gaa 4771Lys Ala Asp Phe Val Val Ala Gly Gly Ile Asp Asp Ile Gln Val Glu

1545 1550 1555tcc ctg acc ggc ttc ggt gac atg aac gcc acc gca gac acc cag gca 4819Ser Leu Thr Gly Phe Gly Asp Met Asn Ala Thr Ala Asp Thr Gln Ala

1560 1565 1570atg ctg gac aag ggc atc gac cca cgc ttc atc tcc cgc gca aac gat 4867Met Leu Asp Lys Gly Ile Asp Pro Arg Phe Ile Ser Arg Ala Asn Asp

1575 1580 1585cga cgt cgc gca ggc ttc ctc gaa gca gca ggt ggc ggt acc gtc ctc 4915Arg Arg Arg Ala Gly Phe Leu Glu Ala Ala Gly Gly Gly Thr Val Leu1590 1595 1600 1605ctg gca cgt gca tcc gtt gct gct gaa ctg gga ctg cca gtt ctc gca 4963Leu Ala Arg Ala Ser Val Ala Ala Glu Leu Gly Leu Pro Val Leu Ala

1610 1615 1620gtt gtt gca cac gca cag tcc tac gcc gat ggt gct cac acc tcc atc 5011Val Val Ala His Ala Gln Ser Tyr Ala Asp Gly Ala His Thr Ser Ile

1625 1630 1635cca gca ccg gga ctt ggc gca ctg ggt gca gca cgt ggt ggc aag aag 5059Pro Ala Pro Gly Leu Gly Ala Leu Gly Ala Ala Arg Gly Gly Lys Lys

1640 1645 1650tcc gta ctt gct cgc gaa ctg aac aaa ttg ggt ctg acc cca gat gac 5107Ser Val Leu Ala Arg Glu Leu Asn Lys Leu Gly Leu Thr Pro Asp Asp

1655 1660 1665gtt cgc gtg gtc tcg aag cac gac acc tcc acc aac gcc aac gat cca 5155Val Arg Val Val Ser Lys His Asp Thr Ser Thr Asn Ala Asn Asp Pro1670 1675 1680 1685aac gag tcc gag ctg cac aac ctg ctg tgg aag acc att gga cgc gaa 5203Asn Glu Ser Glu Leu His Asn Leu Leu Trp Lys Thr Ile Gly Arg Glu

1690 1695 1700gcc gac aac ccg atg ttc gtc gtc tcc cag aag tcc ctt acc gga cac 5251Ala Asp Asn Pro Met Phe Val Val Ser Gln Lys Ser Leu Thr Gly His

1705 1710 1715tca aag ggc ggt gca gca ctc ttc cag atc ggt gga ctt gtc tcc atc 5299Ser Lys Gly Gly Ala Ala Leu Phe Gln Ile Gly Gly Leu Val Ser Ile

1720 1725 1730ctg gaa acc ggc aag ctg cca cag aac gca tcc ctt gac tgc gtt gac 5347Leu Glu Thr Gly Lys Leu Pro Gln Asn Ala Ser Leu Asp Cys Val Asp

1735 1740 1745cca gag atg gaa gca aag ggc gag aac ttc gtc tgg ctg cgc aag cca 5395Pro Glu Met Glu Ala Lys Gly Glu Asn Phe Val Trp Leu Arg Lys Pro1750 1755 1760 1765ctg gat ctc ggc gca ggc tcc att aag gcc ggc gta ctt acc tca ctg 5443Leu Asp Leu Gly Ala Gly Ser Ile Lys Ala Gly Val Leu Thr Ser Leu

1770 1775 1780ggc ttc ggc cac gtg gct gca gtc gtc gtg ctg gca acc agc ggc atc 5491Gly Phe Gly His Val Ala Ala Val Val Val Leu Ala Thr Ser Gly Ile

1785 1790 1795ttc gag cag gca atg cgc aac gca ggc ctc gac gtc gaa gca tgg cgt 5539Phe Glu Gln Ala Met Arg Asn Ala Gly Leu Asp Val Glu Ala Trp Arg

1800 1805 1810gca cgc gca acc cag cgc ctg cgc acc ggt gca aac cgc cta gaa gct 5587Ala Arg Ala Thr Gln Arg Leu Arg Thr Gly Ala Asn Arg Leu Glu Ala

1815 1820 1825ggc atg gtt ggc cga gca cca ttg ttc gag cag gtc gac gga cgt cgc 5635Gly Met Val Gly Arg Ala Pro Leu Phe Glu Gln Val Asp Gly Arg Arg1830 1835 1840 1845ctg cca gag cat ggc gct cac caa gca gag atc aac ttg ctt atc gac 5683Leu Pro Glu His Gly Ala His Gln Ala Glu Ile Asn Leu Leu Ile Asp

1850 1855 1860gct gac gct cgc ctc ggt gct gac ggc atc tac cag ggc taaacgttag 5732Ala Asp Ala Arg Leu Gly Ala Asp Gly Ile Tyr Gln Gly

18651870 atagctaaga aag 5745<210>46<211>1874<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>46Val Arg Ile Val Leu Thr Thr Glu Gly Glu Val Ala Ala Lys Leu Val 151015 Thr Arg Phe Ala Ile Arg Gly Arg Ile Thr Thr Asn Glu Met Ala Ala

20 25 30Pro Ala Asp Ser Tyr Gly Ala Arg Asp Glu Val Val Glu Ala Thr Pro

35 40 45Arg Ser Phe Ile Arg Gln Ala Thr Val Ser Ala Pro Ala Asp Met Thr

50 55 60Pro Phe Ala Met Val Ser Gly Asp Tyr Asn Pro Ile His Thr Ser Asp 65 70 75 80Asn Ala Ala Lys Leu Val Gly Leu Asp Ala Ala Leu Val His Gly Met

85 90 95Trp Leu Ser Ala Thr Ala Gln His Leu Ala Gly Leu Gly Ser Glu Val

100 105 110Ile Gly Trp Thr Tyr Ser Met Tyr Gly Met Val Gln Leu Asn Asp Val

115 120 125Val Asp Ile Thr Val Glu Arg Val Gly Arg Ala Gly Leu Lys Pro Ala

130 135 140Tyr Glu Val Thr Cys Arg Ile Asp Gly Asn Val Val Ser Arg Gly Gln145 150 155 160Ala Leu Leu Lys Ala Pro Ser Thr Ala Tyr Val Tyr Pro Ser Gln Gly

165 170 175Ile Gln Ala Lys Gly Met Gly Gln Gly Asp Arg Thr Ala Ser Ala Glu

180 185 190Ala Arg Ala Val Trp Glu Arg Ala Asp Ala His Thr Arg Ala Asn Leu

195 200 205Gly Phe Ser Ile Gln Gln Val Ile Asp Glu Asn Pro Thr Glu Leu Lys

210 215 220Val Gly Asp Thr Thr Phe Val His Pro Ala Gly Val Leu Asn Leu Thr225 230 235 240Gln Phe Thr Gln Val Ala Leu Ala Val Val Ala Tyr Ala Gln Thr Glu

245 250 255Arg Leu Lys Ala Ala Asn Ala Ile Val Asp Gly Ser Leu Tyr Ala Gly

260 265 270His Ser Leu Gly Glu Tyr Thr Ala Leu Ala Ser Leu Gly Asn Ile Phe

275 280 285Glu Leu Glu Gly Val Ile Asp Val Val Phe Ser Arg Gly Ser Ala Met

290 295 300His Ser Leu Val Pro Arg Asp Glu Lys Gly Arg Ser Asn Tyr Gly Leu305 310 315 320Ala Ala Phe Arg Pro Asn Met Ile Asn Val Ala Ala Thr Glu Val Glu

325 330 335Asn Trp Val Asp Arg Val Ala Glu Glu Ser Gly Glu Phe Leu Gln Ile

340 345 350Val Asn Tyr Asn Val Asp Gly Gln Gln Tyr Ala Val Ala Gly Thr Leu

355 360 365Ala Gly Leu Lys Ala Leu Lys Ala Ser Ala Ser Ala Asn Pro Arg Ala

370 375 380Tyr Val Asn Ile Pro Gly Ile Asp Val Pro Phe His Ser Ser Val Leu385 390 395 400Arg Pro Gly Val Pro Ala Phe Ala Glu Lys Leu Asp Glu Leu Leu Pro

405 410 415Glu Thr Ile Asp Ile Asp Ala Leu Arg Gly Arg Tyr Ile Pro Asn Leu

420 425 430Val Ala Arg Pro Phe Glu Leu Thr Gln Ser Phe Val Asp Ala Ile Leu

435 440 445Ala Val Val Pro Ser Glu Arg Leu Lys Gly Ile Lys Val Glu Asp Thr

450 455 460Asp Glu Asn Thr Leu Ala Arg Leu Leu Leu Ile Glu Leu Leu Ser Trp465 470 475 480Gln Phe Ala Ser Pro Val Arg Trp Ile Glu Thr Gln Ala Leu Ile Ile

485 490 495Asp Thr Val Asp Gln Ile Ile Glu Val Gly Leu Ala Ala Ser Pro Thr

500 505 510Leu Thr Asn Leu Ala Leu Arg Thr Met Asp Val Ile Gly Lys Ser Arg

515 520 525Pro Val Phe Asn Val Glu Arg Asp Gln Asp Thr Val Met Leu Asn Asp

530 535 540Val Arg Gln Ala Pro Val Ala Glu Val Glu Glu Glu Ala Val Glu Glu545 550 555 560Ala Pro Ala Ala Ala Ala Ala Pro Ala Ala Glu Ala Pro Val Ala Ala

565 570 575Ala Pro Val Ala Ala Ala Ala Pro Ala Pro Val Gly Asn Ala Pro Glu

580 585 590Leu Lys Phe Asn Ala Ala Asn Ala Ile Met Val Leu Phe Ala Val Gln

595 600 605Asn Lys Ile Asn Ile Asp Gln Ile Thr Ala Ala Asp Thr Ser Glu Thr

610 615 620Leu Thr Asn Gly Val Ser Ser Arg Arg Asn Gln Met Leu Met Asp Met625 630 635 640Ser Thr Glu Leu Ser Val Pro Thr Ile Asp Gly Ala Ala Asp Ala Asp

645 650 655Val Ala Thr Leu Gln Gly Arg Val Val Thr Ala Ala Pro Gly Tyr Lys

660 665 670Pro Phe Gly Pro Val Leu Ser Glu Thr Val Arg Ala Arg Leu Arg Ala

675 680 685Leu Thr Gly Ala Ala Gly Leu Lys Thr Ser Tyr Ile Gly Asp Arg Val

690 695 700Thr Gly Thr Trp Gly Leu Pro Glu Ser Trp Thr Ala His Val Glu Val705 710 715 720Glu Leu Leu Leu Gly Thr Arg Glu Gly Glu Ser Val Arg Gly Gly Asn

725 730 735Leu Gly Ser Leu Pro Ala Asn Ala Ser Ser Lys Gly Asp Val Asp Ala

740 745 750Leu Ile Asp Ala Ala Val Gln Asn Val Ala Ala Ala Asn Gly Thr Ser

755 760 765Val Ser Met Ser Ser Gly Gly Ala Ala Ser Gly Gly Gly Val Val Asp

770 775 780Ser Ala Ala Leu Asp Ala Tyr Ala Ser Thr Val Thr Gly Glu Glu Gly785 790 795800Val Leu Ala Asn Val Ala Arg Gly Ile Leu Ser Gln Leu Gly Leu Asp

805 810 815Thr Lys Asp Glu Val Glu Gly Ala Glu Ile Asp Thr Glu Leu Tyr Asp

820 825 830Ala Val Glu Ala Glu Leu Gly Thr Gly Trp Leu Lys Leu Val Thr Pro

835 840 845Val Phe Ser Ala Asp Arg Ala Ile Leu Phe Asp Asp Arg Trp Ala Ser

850 855 860Ala Arg Glu Asp Leu Ala Arg Leu Ala Asn Gly Glu Asp Ile Ala Val865 870 875 880Glu Arg Phe Ala Gly Thr Gly Glu Thr Val Val Lys Gln Ala Ala Trp

885 890 895Trp Ala Glu His Val Glu Asp Thr Ala Leu Ala Ala Thr Leu Lys Gln

900 905 910Val Ser Glu Val Ala Ala Lys Pro Ala Asn Glu Pro His Ile Asp Asp

915 920 925Val Ala Leu Val Thr Gly Ala Ala Pro Glu Ser Ile Ala Gly Ala Val

930 935 940Ala Ala Arg Leu Leu Ser Gln Gly Ala Thr Val Ile Leu Thr Ala Ser945 950 955 960Asn Val Ser Gln Ala Arg Lys GIu Tyr Ala Arg Lys Leu Tyr Ala Ala

965 970 975Asn Ala Thr Pro Asn Ala Lys Leu Trp Ile Val Pro Ala Asn Met Ser

980 985 990Ser Tyr Arg Asp Val Asp Ala Val Ile Asp Trp Ile Gly Asn Glu Gln

995 1000 1005Arg Val Thr Val Gly Ser Thr Val Thr Val Thr Lys Pro Ala Leu Thr

1010 1015 1020Pro Thr Leu Ala Tyr Pro Phe Ala Ala Pro Ser Val Ser Gly Thr Leu1025 1030 1035 1040Ala Asp Ala Gly Pro Gln Ala Glu Asn Gln Ala Arg Leu Leu Leu Trp

1045 1050 1055Ser Val Glu Arg Thr Ile Ala Gly Leu Ala Asp Leu Ala Ser Arg Gly

1060 1065 1070Val Asp Gly Arg Val His Val Val Leu Pro Gly Ser Pro Asn Arg Gly

1075 1080 1085Met Phe Gly Gly Asp Gly Ala Tyr Gly Glu Val Lys Ala Ala Phe Asp

1090 1095 1100Ala Ile Leu Ala Lys Trp Gly Ser Glu Thr Gly Trp Pro Gln Phe Val1105 1110 1115 1120Ser Leu Ala Gln Ala Arg Ile Gly Trp Val Ala Gly Thr Gly Leu Met

1125 1130 1135Gly Arg Asn Asp Val Leu Ile Pro Ala Ala Glu Lys Leu Gly Ile His

1140 1145 1150Val Tyr Thr Pro Glu Glu Ile Ser Ser Glu Leu Leu Gly Leu Ala Ser

1155 1160 1165Ala Glu Ser Arg Glu Lys Ala Leu Glu Ala Pro Ile Asp Tyr Asp Leu

1170 1175 1180Thr Gly Gly Leu Ser Gly Gly Val Ser Ile Ala Ala Leu Ala Ala Ser1185 1190 1195 1200Leu Glu Ser Asp Ala Val Glu Thr Thr Ser Ala Ala Glu Asp Thr Ile

1205 1210 1215Lys Ala Leu Pro Ser Pro Lys His Pro Glu Gln Pro Val Gly Thr Pro

1220 1225 1230Val Gly Glu Val Lys Thr Asp Leu Glu Asp Met Val Val Met Val Gly

1235 1240 1245Val Gly Glu Val Ser Ser Trp Gly Ser Gly Arg Thr Arg Phe Glu Ala

1250 1255 1260Glu Tyr Gly Ile Gln Arg Asp Gly Ser Val Asp Leu Thr Ala Ala Gly 1265 1270 1275 1280Val Leu Glu Leu Ala Trp Met Met Gly Leu Ile Ser Trp Ser Glu Asp

1285 1290 1295Pro Lys Pro Ala Trp Tyr Asp Ala Asp Gly Thr Glu Val Pro Glu Glu

1300 1305 1310Glu Ile Tyr Glu Arg Phe Arg Asp Glu Val Ile Ala Arg Cys Gly Val

1315 1320 1325Arg Glu Leu Val Asp Asp Ala Phe Leu Val Asp Gly Gly Ser Leu Asp

1330 1335 1340Ala Ala Glu Val Phe Leu Asp Arg Asp Ile Ser Phe Ser Val Thr Ser1345 1350 1355 1360Ala Glu Glu Ala Gln Ala Tyr Val Asp Ala Asp Ala Ser Val Thr Val

1365 1370 1375Glu Glu Ala Asp Gly Glu Trp Ile Val Thr Lys Lys Lys Gly Ser Thr

1380 1385 1390Ser Phe Val Pro Arg Lys Ala Thr Leu Thr Arg Ser Val Ala Gly Gln

1395 1400 1405Leu Pro Thr Asp Phe Asp Pro Ala Lys Trp Gly Ile Pro Ala Ser Met

1410 1415 1420Ile Asp Ala Leu Asp Asn Ile Ala Ala Trp Asn Leu Val Thr Ala Val1425 1430 1435 1440Asp Ala Phe Leu Ser Ser Gly Phe Ser Pro Ala Glu Leu Leu Gln Ser

1445 1450 1455Ile His Pro Ala Asp Val Ser Ser Thr Gln Gly Thr Gly Ile Gly Gly

1460 14651470Met Gln Ser Leu Arg Lys Leu Phe Val Asn Arg Phe Leu Gly Gln Asp

1475 1480 1485Arg Pro Ser Asp Ile Leu Gln Glu Thr Leu Pro Asn Val Val Ala Ala

1490 1495 1500His Thr Met Gln Ser Tyr Val Gly Gly Tyr Gly Gln Met Ile His Pro1505 1510 1515 1520Val Ala Ala Cys Ala Thr Ala Ala Val Ser Val Glu Glu Gly Val Asp

1525 1530 1535Lys Ile Arg Leu Asn Lys Ala Asp Phe Val Val Ala Gly Gly Ile Asp

1540 1545 1550Asp Ile Gln Val Glu Ser Leu Thr Gly Phe Gly Asp Met Asn Ala Thr

1555 1560 1565Ala Asp Thr Gln Ala Met Leu Asp Lys Gly Ile Asp Pro Arg Phe Ile

1570 1575 1580Ser Arg Ala Asn Asp Arg Arg Arg Ala Gly Phe Leu Glu Ala Ala Gly1585 1590 1595 1600Gly Gly Thr Val Leu Leu Ala Arg Ala Ser Val Ala Ala Glu Leu Gly

1605 1610 1615Leu Pro Val Leu Ala Val Val Ala His Ala Gln Ser Tyr Ala Asp Gly

1620 1625 1630Ala His Thr Ser Ile Pro Ala Pro Gly Leu Gly Ala Leu Gly Ala Ala

1635 1640 1645Arg Gly Gly Lys Lys Ser Val Leu Ala Arg Glu Leu Asn Lys Leu Gly

1650 1655 1660Leu Thr Pro Asp Asp Val Arg Val Val Ser Lys His Asp Thr Ser Thr1665 1670 1675 1680Asn Ala Asn Asp Pro Asn Glu Ser Glu Leu His Asn Leu Leu Trp Lys

1685 1690 1695Thr Ile Gly Arg Glu Ala Asp Asn Pro Met Phe Val Val Ser Gln Lys

1700 1705 1710Ser Leu Thr Gly His Ser Lys Gly Gly Ala Ala Leu Phe Gln Ile Gly

1715 1720 1725Gly Leu Val Ser Ile Leu Glu Thr Gly Lys Leu Pro Gln Asn Ala Ser

1730 1735 1740Leu Asp Cys Val Asp Pro Glu Met Glu Ala Lys Gly Glu Asn Phe Val1745 1750 1755 1760Trp Leu Arg Lys Pro Leu Asp Leu Gly Ala Gly Ser Ile Lys Ala Gly

1765 1770 1775Val Leu Thr Ser Leu Gly Phe Gly His Val Ala Ala Val Val Val Leu

1780 1785 1790Ala Thr Ser Gly Ile Phe Glu Gln Ala Met Arg Asn Ala Gly Leu Asp

1795 1800 1805Val Glu Ala Trp Arg Ala Arg Ala Thr Gln Arg Leu Arg Thr Gly Ala

1810 1815 1820Asn Arg Leu Glu Ala Gly Met Val Gly Arg Ala Pro Leu Phe Glu Gln1825 1830 1835 1840Val Asp Gly Arg Arg Leu Pro Glu His Gly Ala His Gln Ala Glu Ile

1845 1850 1855Asn Leu Leu Ile Asp Ala Asp Ala Arg Leu Gly Ala Asp Gly Ile Tyr

186018651870 Gln Gly<210>47<211>3317<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (3294)<223>FRXA00113<400>47gct tca ggt ggc gga gtt gtt gat tcc gca gca ctt gat gcc tac gca 48Ala Ser Gly Gly Gly Val Val Asp Ser Ala Ala Leu Asp Ala Tyr Ala 151015 tcc acc gtc act ggt gaa gaa ggc gtc ctg gca aac gtt gcr cgc ggc 96Ser Thr Val Thr Gly Glu Glu Gly Val Leu Ala Asn Val Ala Arg Gly

20 25 30att ctg tct cag ctt ggt ctc gac acc aag gac gag gtt gaa ggc gca 144Ile Leu Ser Gln Leu Gly Leu Asp Thr Lys Asp Glu Val Glu Gly Ala

35 40 45gag atc gac acc gaa ctc tac gac gct gtc gaa gca gaa ctg ggc acc 192Glu Ile Asp Thr Glu Leu Tyr Asp Ala Val Glu Ala Glu Leu Gly Thr

50 55 60ggc tgg ctg aag ctt gtc acc cca gtg ttc tcc gct gat cgt gcg atc 240Gly Trp Leu Lys Leu Val Thr Pro Val Phe Ser Ala Asp Arg Ala Ile 65 70 75 80ttg ttc gac gac cgt tgg gca tct gca cgt gaa gat ctg gca cgc ctt 288Leu Phe Asp Asp Arg Trp Ala Ser Ala Arg Glu Asp Leu Ala Arg Leu

85 90 95gcc aac ggc gag gat att gcc gtc gag cgc ttt gct gga acg ggg gag 336Ala Asn Gly Glu Asp Ile Ala Val Glu Arg Phe Ala Gly Thr Gly Glu

100 105 110acc gtc gtc aag caa gct gca tgg tgg gct gag cac gtt gaa gac acc 384Thr Val Val Lys Gln Ala Ala Trp Trp Ala Glu His Val Glu Asp Thr

115 120 125gct ctc gct gca acc ctg aag cag gtt tcc gag gtg gct gcg aag cca 432Ala Leu Ala Ala Thr Leu Lys Gln Val Ser Glu Val Ala Ala Lys Pro

130 135 140gcc aac gag cca cac atc gac gat gtt gcg ctg gtt acc ggt gcg gct 480Ala Asn Glu Pro His Ile Asp Asp Val Ala Leu Val Thr Gly Ala Ala145 150 155 160cct gag tcg atc gcc ggt gca gtt gcg gct cgc ctg ctg tcc cag ggc 528Pro Glu Ser Ile Ala Gly Ala Val Ala Ala Arg Leu Leu Ser Gln Gly

165 170 175gcg acc gtc att ctc acc gca tcg aac gtc tcccag gcg cgt aag gaa 576Ala Thr Val Ile Leu Thr Ala Ser Asn Val Ser Gln Ala Arg Lys Glu

180 185 190tac gca cgc aag ctc tac gct gcg aac gca acc cct aac gca aag ctg 624Tyr Ala Arg Lys Leu Tyr Ala Ala Asn Ala Thr Pro Asn Ala Lys Leu

l95 200 205tgg att gtt cct gcg aac atg tcc tcc tac cgc gat gtt gat gca gtc 672Trp Ile Val Pro Ala Asn Met Ser Ser Tyr Arg Asp Val Asp Ala Val

210 215 220atc gat tgg atc ggc aac gag cag cgc gtc acc gtc ggc agc acc gtc 720Ile Asp Trp Ile Gly Asn Glu Gln Arg Val Thr Val Gly Ser Thr Val225 230 235 240acc gtg acc aag cca gct ctg acc cca acc ctt gcg tac cca ttc gca 768Thr Val Thr Lys Pro Ala Leu Thr Pro Thr Leu Ala Tyr Pro Phe Ala

245 250 255gct cca tcc gta tcc ggt acc ttg gcg gat gca ggc cca cag gct gaa 816Ala Pro Ser Val Ser Gly Thr Leu Ala Asp Ala Gly Pro Gln Ala Glu

260 265 270aac cag gca cgc ctg ctc ctc tgg tcc gtg gag cgc acc atc gca gga 864Asn Gln Ala Arg Leu Leu Leu Trp Ser Val Glu Arg Thr Ile Ala Gly

275 280 285ctt gca gat ctt gca tcc cgc ggt gtc gat gga cgc gtc cac gtt gta 912Leu Ala Asp Leu Ala Ser Arg Gly Val Asp Gly Arg Val His Val Val

290 295 300ctc cca ggt tcc ccg aac cgc gga atg ttc ggt ggc gac ggc gct tac 960Leu Pro Gly Ser Pro Asn Arg Gly Met Phe Gly Gly Asp Gly Ala Tyr305 310 315 320ggc gaa gtc aag gct gct ttc gac gcc atc ctt gcc aag tgg ggc tcc 1008Gly Glu Val Lys Ala Ala Phe Asp Ala Ile Leu Ala Lys Trp Gly Ser

325 330 335gag acc ggc tgg cca cag ttt gtc tcc ctc gca cag gca cgc atc ggc 1056Glu Thr Gly Trp Pro Gln Phe Val Ser Leu Ala Gln Ala Arg Ile Gly

340 345 350tgg gtc gca ggc acc ggc ctc atg ggt cgc aac gac gtg ctc atc cct 1104Trp Val Ala Gly Thr Gly Leu Met Gly Arg Asn Asp Val Leu Ile Pro

355 360 365gcc gct gaa aag ctg ggc atc cac gtc tac acc cct gaa gag atc tct 1152Ala Ala Glu Lys Leu Gly Ile His Val Tyr Thr Pro Glu Glu Ile Ser

370 375 380tcc gaa ctg ctg ggt ctt gca tcc gca gaa tcc cgc gaa aag gct ctg 1200Ser Glu Leu Leu Gly Leu Ala Ser Ala Glu Ser Arg Glu Lys Ala Leu385 390 395 400gaa gca ccg atc gat tac gac ctg acc ggt gga ctt tcc ggt ggc gta 1248Glu Ala Pro Ile Asp Tyr Asp Leu Thr Gly Gly Leu Ser Gly Gly Val

405 410 415tcc atc gca gca ctg gca gca tcc ctc gag tcc gac gca gta gag acc 1296Ser Ile Ala Ala Leu Ala Ala Ser Leu Glu Ser Asp Ala Val Glu Thr

420 425 430acc tct gca gca gaa gac acc atc aag gcg ctt cca tca cct aag cac 1344Thr Ser Ala Ala Glu Asp Thr Ile Lys Ala Leu Pro Ser Pro Lys His

435 440 445cca gag cag cca gtg ggc acg cca gtt gga gag gtc aag acc gat ctc 1392Pro Glu Gln Pro Val Gly Thr Pro Val Gly Glu Val Lys Thr Asp Leu

450 455 460gaa gac atg gtt gtc atg gtt ggc gtt ggc gaa gtc tcc tca tgg ggc 1440Glu Asp Met Val Val Met Val Gly Val Gly Glu Val Ser Ser Trp Gly465 470 475 480tcc gga cgt acc cgc ttc gaa gct gag tac ggc atc cag cgc gac ggc 1488Ser Gly Arg Thr Arg Phe Glu Ala Glu Tyr Gly Ile Gln Arg Asp Gly

485 490 495tcc gtt gac ctc acc gca gca ggc gtc ctt gag ctt gca tgg atg atg 1536Ser Val Asp Leu Thr Ala Ala Gly Val Leu Glu Leu Ala Trp Met Met

500 505 510ggt ctg atc tcc tgg agc gaa gat cca aag cca gcc tgg tac gac gct 1584Gly Leu Ile Ser Trp Ser Glu Asp Pro Lys Pro Ala Trp Tyr Asp Ala

515 520 525gac ggc acc gaa gtg cct gaa gaa gag atc tac gag cgc ttc cgc gac 1632Asp Gly Thr Glu Val Pro Glu Glu Glu Ile Tyr Glu Arg Phe Arg Asp

530 535 540gaa gtc atc gca cga tgc ggt gtt cgt gag ctt gtc gac gac gca ttc 1680Glu Val Ile Ala Arg Cys Gly Val Arg Glu Leu Val Asp Asp Ala Phe545 550 555 560ctc gtc gac ggc ggc tcc ctc gac gca gct gaa gtc ttc ctc gac cgc 1728Leu Val Asp Gly Gly Ser Leu Asp Ala Ala Glu Val Phe Leu Asp Arg

565 570 575gac atc tcc ttc tcc gta acc tct gct gaa gaa gca cag gcc tac gtc 1776Asp Ile Ser Phe Ser Val Thr Ser Ala Glu Glu Ala Gln Ala Tyr Val

580 585 590gat gca gat gct tcc gtg acc gtt gaa gaa gca gac ggc gaa tgg atc 1824Asp Ala Asp Ala Ser Val Thr Val Glu Glu Ala Asp Gly Glu Trp Ile

595 600 605gtg acc aag aag aag ggc tcc acc tcc ttc gtg cca cgc aag gca acc 1872Val Thr Lys Lys Lys Gly Ser Thr Ser Phe Val Pro Arg Lys Ala Thr

610 615 620ctg acc cgc tcc gta gca ggc cag ctg cca acc gac ttc gac cct gcc 1920Leu Thr Arg Ser Val Ala Gly Gln Leu Pro Thr Asp Phe Asp Pro Ala625 630635 640aag tgg ggt atc cca gcc tcc atg atc gat gca ctc gac aac atc gca 1968Lys Trp Gly Ile Pro Ala Ser Met Ile Asp Ala Leu Asp Asn Ile Ala

645 650 655gcg tgg aac ctg gtc act gca gtc gac gcc ttc ctg tcc tcc ggc ttc 2016Ala Trp Asn Leu Val Thr Ala Val Asp Ala Phe Leu Ser Ser Gly Phe

660 665 670agc cca gca gaa ctc ctg cag tcc atc cac cca gct gac gtg tcc tcc 2064Ser Pro Ala Glu Leu Leu Gln Ser Ile His Pro Ala Asp Val Ser Ser

675 680 685acc cag ggc acc ggt atc ggt ggc atg cag tcc cta cgc aag ctg ttc 2112Thr Gln Gly Thr Gly Ile Gly Gly Met Gln Ser Leu Arg Lys Leu Phe

690 695 700gtc aac cgc ttc ctc ggc cag gat cgt cca tcc gac atc ctc cag gag 2160Val Asn Arg Phe Leu Gly Gln Asp Arg Pro Ser Asp Ile Leu Gln Glu705 710 715 720acc ctg cca aac gtt gtg gct gca cac acc atg cag tcc tac gtc ggt 2208Thr Leu Pro Asn Val Val Ala Ala His Thr Met Gln Ser Tyr Val Gly

725 730 735ggc tac ggc cag atg atc cac cca gtg gca gca tgt gca acc gca gct 2256Gly Tyr Gly Gln Met Ile His Pro Val Ala Ala Cys Ala Thr Ala Ala

740 745 750gtc tcc gtg gaa gaa ggc gtg gac aag atc cgc ctc aac aag gca gat 2304Val Ser Val Glu Glu Gly Val Asp Lys Ile Arg Leu Asn Lys Ala Asp

755 760 765ttc gtt gtc gcc ggt ggt atc gat gac atc cag gtt gaa tcc ctg acc 2352Phe Val Val Ala Gly Gly Ile Asp Asp Ile Gln Val Glu Ser Leu Thr

770 775 780ggc ttc ggt gac atg aac gcc acc gca gac acc cag gca atg ctg gac 2400Gly Phe Gly Asp Met Asn Ala Thr Ala Asp Thr Gln Ala Met Leu Asp785 790 795 800aag ggc atc gac cca cgc ttc atc tcc cgc gca aac gat cga cgt cgc 2448Lys Gly Ile Asp Pro Arg Phe Ile Ser Arg Ala Asn Asp Arg Arg Arg

805 810 815gca ggc ttc ctc gaa gca gca ggt ggc ggt acc gtc ctc ctg gca cgt 2496Ala Gly Phe Leu Glu Ala Ala Gly Gly Gly Thr Val Leu Leu Ala Arg

820 825 830gca tcc gtt gct gct gaa ctg gga ctg cca gtt ctc gca gtt gtt gca 2544Ala Ser Val Ala Ala Glu Leu Gly Leu Pro Val Leu Ala Val Val Ala

835 840 845cac gca cag tcc tac gcc gat ggt gct cac acc tcc atc cca gca ccg 2592His Ala Gln Ser Tyr Ala Asp Gly Ala His Thr Ser Ile Pro Ala Pro

850 855 860gga ctt ggc gca ctg ggt gca gca cgt ggt ggc aag aag tcc gta ctt 2640Gly Leu Gly Ala Leu Gly Ala Ala Arg Gly Gly Lys Lys Ser Val Leu865 870 875 880gct cgc gaa ctg aac aaa ttg ggt ctg acc cca gat gac gtt cgc gtg 2688Ala Arg Glu Leu Asn Lys Leu Gly Leu Thr Pro Asp Asp Val Arg Val

885 890 895gtc tcg aag cac gac acc tcc acc aac gcc aac gat cca aac gag tcc 2736Val Ser Lys His Asp Thr Ser Thr Asn Ala Asn Asp Pro Asn Glu Ser

900 905 910gag ctg cac aac ctg ctg tgg aag acc att gga cgc gaa gcc gac aac 2784Glu Leu His Asn Leu Leu Trp Lys Thr Ile Gly Arg Glu Ala Asp Asn

915 920 925ccg atg ttc gtc gtc tcc cag aag tcc ctt acc gga cac tca aag ggc 2832Pro Met Phe Val Val Ser Gln Lys Sar Leu Thr Gly His Ser Lys Gly

930 935 940ggt gca gca ctc ttc cag atc ggt gga ctt gtc tcc atc ctg gaa acc 2880Gly Ala Ala Leu Phe Gln Ile Gly Gly Leu Val Ser Ile Leu Glu Thr945 950 955 960ggc aag ctg cca cag aac gca tcc ctt gac tgc gtt gac cca gag atg 2928Gly Lys Leu Pro Gln Asn Ala Ser Leu Asp Cys Val Asp Pro Glu Met

965 970 975gaa gca aag ggc gag aac ttc gtc tgg ctg cgc aag cca ctg gat ctc 2976Glu Ala Lys Gly Glu Asn Phe Val Trp Leu Arg Lys Pro Leu Asp Leu

980 985 990ggc gca ggc tcc att aag gcc ggc gta ctt acc tca ctg ggc ttc ggc 3024Gly Ala Gly Ser Ile Lys Ala Gly Val Leu Thr Ser Leu Gly Phe Gly

995 1000 1005cac gtg gct gca gtc gtc gtg ctg gca acc agc ggc atc ttc gag cag 3072His Val Ala Ala Val Val Val Leu Ala Thr Ser Gly Ile Phe Glu Gln

1010 1015 1020gca atg cgc aac gca ggc ctc gac gtc gaa gca tgg cgt gca cgc gca 3120Ala Met Arg Asn Ala Gly Leu Asp Val Glu Ala Trp Arg Ala Arg Ala1025 1030 1035 1040acc cag cgc ctg cgc acc ggt gca aac cgc cta gaa gct ggc atg gtt 3168Thr Gln Arg Leu Arg Thr Gly Ala Asn Arg Leu Glu Ala Gly Met Val

1045 1050 1055ggc cga gca cca ttg ttc gag cag gtc gac gga cgt cgc ctg cca gag 3216Gly Arg Ala Pro Leu Phe Glu Gln Val Asp Gly Arg Arg Leu Pro Glu

1060 1065 1070cat ggc gct cac caa gca gag atc aac ttg ctt atc gac gct gac gct 3264His Gly Ala His Gln Ala Glu Ile Asn Leu Leu Ile Asp Ala Asp Ala

1075 1080 1085cgc ctc ggt gct gac ggc atc tac cag ggc taaacgttagatagctaaga 3314Arg Leu Gly Ala Asp Gly Ile Tyr Gln Gly

10901095 aag3317<210>48<211>1098<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>48Ala Ser Gly Gly Gly Val Val Asp Ser Ala Ala Leu Asp Ala Tyr Ala 151015 Ser Thr Val Thr Gly Glu Glu Gly Val Leu Ala Asn Val Ala Arg Gly

20 25 30Ile Leu Ser Gln Leu Gly Leu Asp Thr Lys Asp Glu Val Glu Gly Ala

35 40 45Glu Ile Asp Thr Glu Leu Tyr Asp Ala Val Glu Ala Glu Leu Gly Thr

50 55 60Gly Trp Leu Lys Leu Val Thr Pro Val Phe Ser Ala Asp Arg Ala Ile 65 70 75 80Leu Phe Asp Asp Arg Trp Ala Ser Ala Arg Glu Asp Leu Ala Arg Leu

85 90 95Ala Asn Gly Glu Asp Ile Ala Val Glu Arg Phe Ala Gly Thr Gly Glu

100 105 110Thr Val Val Lys Gln Ala Ala Trp Trp Ala Glu His Val Glu Asp Thr

115 120 125Ala Leu Ala Ala Thr Leu Lys Gln Val Ser Glu Val Ala Ala Lys Pro

130 135 140Ala Asn Glu Pro His Ile Asp Asp Val Ala Leu Val Thr Gly Ala Ala145 150 155 160Pro Glu Ser Ile Ala Gly Ala Val Ala Ala Arg Leu Leu Ser Gln Gly

165 170 175Ala Thr Val Ile Leu Thr Ala Ser Asn Val Ser Gln Ala Arg Lys Glu

180 185 190Tyr Ala Arg Lys Leu Tyr Ala Ala Asn Ala Thr Pro Asn Ala Lys Leu

195 200205Trp Ile Val Pro Ala Asn Met Ser Ser Tyr Arg Asp Val Asp Ala Val

210 215 220Ile Asp Trp Ile Gly Asn Glu Gln Arg Val Thr Val Gly Ser Thr Val225 230 235 240Thr Val Thr Lys Pro Ala Leu Thr Pro Thr Leu Ala Tyr Pro Phe Ala

245 250 255Ala Pro Ser Val Ser Gly Thr Leu Ala Asp Ala Gly Pro Gln Ala Glu

260 265 270Asn Gln Ala Arg Leu Leu Leu Trp Ser Val Glu Arg Thr Ile Ala Gly

275 280 285Leu Ala Asp Leu Ala Ser Arg Gly Val Asp Gly Arg Val His Val Val

290 295 300Leu Pro Gly Ser Pro Asn Arg Gly Met Phe Gly Gly Asp Gly Ala Tyr305 310 315 320Gly Glu Val Lys Ala Ala Phe Asp Ala Ile Leu Ala Lys Trp Gly Ser

325 330 335Glu Thr Gly Trp Pro Gln Phe Val Ser Leu Ala Gln Ala Arg Ile Gly

340 345 350Trp Val Ala Gly Thr Gly Leu Met Gly Arg Asn Asp Val Leu Ile Pro

355 360 365Ala Ala Glu Lys Leu Gly Ile His Val Tyr Thr Pro Glu Glu Ile Ser

370 375 380Ser Glu Leu Leu Gly Leu Ala Ser Ala Glu Ser Arg Glu Lys Ala Leu385 390 395 400Glu Ala Pro Ile Asp Tyr Asp Leu Thr Gly Gly Leu Ser Gly Gly Val

405 410 415Ser Ile Ala Ala Leu Ala Ala Ser Leu Glu Ser Asp Ala Val Glu Thr

420 425 430Thr Ser Ala Ala Glu Asp Thr Ile Lys Ala Leu Pro Ser Pro Lys His

435 440 445Pro Glu Gln Pro Val Gly Thr Pro Val Gly Glu Val Lys Thr Asp Leu

450 455 460Glu Asp Met Val Val Met Val Gly Val Gly Glu Val Ser Ser Trp Gly465 470 475 480Ser Gly Arg Thr Arg Phe Glu Ala Glu Tyr Gly Ile Gln Arg Asp Gly

485 490 495Ser Val Asp Leu Thr Ala Ala Gly Val Leu Glu Leu Ala Trp Met Met

500 505 510Gly Leu Ile Ser Trp Ser Glu Asp Pro Lys Pro Ala Trp Tyr Asp Ala

515 520 525Asp Gly Thr Glu Val Pro Glu Glu Glu Ile Tyr Glu Arg Phe Arg Asp

530 535 540Glu Val Ile Ala Arg Cys Gly Val Arg Glu Leu Val Asp Asp Ala Phe545 550 555 560Leu Val Asp Gly Gly Ser Leu Asp Ala Ala Glu Val Phe Leu Asp Arg

565 570 575Asp Ile Ser Phe Ser Val Thr Ser Ala Glu Glu Ala Gln Ala Tyr Val

580 585 590Asp Ala Asp Ala Ser Val Thr Val Glu Glu Ala Asp Gly Glu Trp Ile

595 600 605Val Thr Lys Lys Lys Gly Ser Thr Ser Phe Val Pro Arg Lys Ala Thr

610 615 620Leu Thr Arg Ser Val Ala Gly Gln Leu Pro Thr Asp Phe Asp Pro Ala625 630 635 640Lys Trp Gly Ile Pro Ala Ser Met Ile Asp Ala Leu Asp Asn Ile Ala

645 650 655Ala Trp Asn Leu Val Thr Ala Val Asp Ala Phe Leu Ser Ser Gly Phe

660 665 670Ser Pro Ala Glu Leu Leu Gln Ser Ile His Pro Ala Asp Val Ser Ser

675 680 685Thr Gln Gly Thr Gly Ile Gly Gly Met Gln Ser Leu Arg Lys Leu Phe

690 695 700Val Asn Arg Phe Leu Gly Gln Asp Arg Pro Ser Asp Ile Leu Gln Glu705 710 715 720Thr Leu Pro Asn Val Val Ala Ala His Thr Met Gln Ser Tyr Val Gly

725 730 735Gly Tyr Gly Gln Met Ile His Pro Val Ala Ala Cys Ala Thr Ala Ala

740 745 750Val Ser Val Glu Glu Gly Val Asp Lys Ile Arg Leu Asn Lys Ala Asp

755 760 765Phe Val Val Ala Gly Gly Ile Asp Asp Ile Gln Val Glu Ser Leu Thr

770 775 780Gly Phe Gly Asp Met Asn Ala Thr Ala Asp Thr Gln Ala Met Leu Asp785 790 795 800Lys Gly Ile Asp Pro Arg Phe Ile Ser Arg Ala Asn Asp Arg Arg Arg

805 810 815Ala Gly Phe Leu Glu Ala Ala Gly Gly Gly Thr Val Leu Leu Ala Arg

820 825 830Ala Ser Val Ala Ala Glu Leu Gly Leu Pro Val Leu Ala Val Val Ala

835 840 845His Ala Gln Ser Tyr Ala Asp Gly Ala His Thr Ser Ile Pro Ala Pro

850 855 860Gly Leu Gly Ala Leu Gly Ala Ala Arg Gly Gly Lys Lys Ser Val Leu865 870 875 880Ala Arg Glu Leu Asn Lys Leu Gly Leu Thr Pro Asp Asp Val Arg Val

885 890 895Val Ser Lys His Asp Thr Ser Thr Asn Ala Asn Asp Pro Asn Glu Ser

900 905 910Glu Leu His Asn Leu Leu Trp Lys Thr Ile Gly Arg Glu Ala Asp Asn

915 920 925Pro Met Phe Val Val Ser Gln Lys Ser Leu Thr Gly His Ser Lys Gly

930 935 940Gly Ala Ala Leu Phe Gln Ile Gly Gly Leu Val Ser Ile Leu Glu Thr945 950 955 960Gly Lys Leu Pro Gln Asn Ala Ser Leu Asp Cys Val Asp Pro Glu Met

965 970 975Glu Ala Lys Gly Glu Asn Phe Val Trp Leu Arg Lys Pro Leu Asp Leu

980 985 990Gly Ala Gly Ser Ile Lys Ala Gly Val Leu Thr Ser Leu Gly Phe Gly

995 1000 1005His Val Ala Ala Val Val Val Leu Ala Thr Ser Gly Ile Phe Glu Gln

1010 1015 1020Ala Met Arg Asn Ala Gly Leu Asp Val Glu Ala Trp Arg Ala Arg Ala1025 1030 1035 1040Thr Gln Arg Leu Arg Thr Gly Ala Asn Arg Leu Glu Ala Gly Met Val

1045 1050 1055Gly Arg Ala Pro Leu Phe Glu Gln Val Asp Gly Arg Arg Leu Pro Glu

1060 1065 1070His Gly Ala His Gln Ala Glu Ile Asn Leu Leu Ile Asp Ala Asp Ala

1075 1080 1085Arg Leu Gly Ala Asp Gly Ile Tyr Gln Gly

10901095<210>49<211>6136<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (6136)<223>RXN03111<400>49cgtgaccgaa ttgagcagga acttcggggc cagccgactg attaaccgct ttggccagga 60gccttttgcc ttcgctttcg ccggccaagg atatgactgg ttg aag acc ctt cgt 115

Leu Lys Thr Leu Arg

1 5gcc gcg gtt gcc gca ggt gca ggc acc aat gtt agt gac atc gtc gag 163Ala Ala Val Ala Ala Gly Ala Gly Thr Asn Val Ser Asp Ile Val Glu

10 15 20cgc gca aat gcg ctg ctt gca cta gtt gca gat gat ctc att ggc acc 211Arg Ala Asn Ala Leu Leu Ala Leu Val Ala Asp Asp Leu Ile Gly Thr

25 30 35ctt cca ttt ggt ttc gat cca gtg gct tgg gct aac aac tcc gaa gat 259Leu Pro Phe Gly Phe Asp Pro Val Ala Trp Ala Asn Asn Ser Glu Asp

40 45 50cca gct ttc gat act gca caa tct gca gtg agc gtg ccg ggt atc ttt 307Pro Ala Phe Asp Thr Ala Gln Ser Ala Val Ser Val Pro Gly Ile Phe

55 60 65gtc tcc cag atc gca acc ctg gat tcc ctt gag gcg cag cgc ctt gat 355Val Ser Gln Ile Ala Thr Leu Asp Ser Leu Glu Ala Gln Arg Leu Asp 70 75 80 85gtg gat cag gct gtg tcc agc att ggt cat tcc cag ggc gta ttg ggc 403Val Asp Gln Ala Val Ser Ser Ile Gly His Ser Gln Gly Val Leu Gly

90 95 100gtg cac ctg ctc aat gat gcg act cgt gct gat gaa ctc gtt gcc att 451Val His Leu Leu Asn Asp Ala Thr Arg Ala Asp Glu Leu Val Ala Ile

105 110 115gcg cag ttg atc ggt gca gcg atc acc cgc acc gca cgc atg acg ggc 499Ala Gln Leu Ile Gly Ala Ala Ile Thr ArgThr Ala Arg Met Thr Gly

120 125 130ctg atc gcg cag ggc gac aac atg ccg atg ctg tcg atc gcc gga att 547Leu Ile Ala Gln Gly Asp Asn Met Pro Met Leu Ser Ile Ala Gly Ile

135 140 145tcc cgc gaa cag ctt cag caa gct atc gac gcg gcc tgc gcc gaa gtc 595Ser Arg Glu Gln Leu Gln Gln Ala Ile Asp Ala Ala Cys Ala Glu Val150 155 160 165cct gcg gag atc cgc ccg gtt atc ggt ctg cgc aac tca cgc gat tct 643Pro Ala Glu Ile Arg Pro Val Ile Gly Leu Arg Asn Ser Arg Asp Ser

170 175 180tat gtt ttg gtt ggc cgc cca gac gac aac gct cgc gtt gtt aag gtc 691Tyr Val Leu Val Gly Arg Pro Asp Asp Asn Ala Arg Val Val Lys Val

185 190 195att gag gca atg gct gcc aag gat aag aag gcc att gaa gat aag ctg 739Ile Glu Ala Met Ala Ala Lys Asp Lys Lys Ala Ile Glu Asp Lys Leu

200 205 210cgc ggc ggt tcc gcg ttc agc ccc cgt att act ccg ctg aag gtg cag 787Arg Gly Gly Ser Ala Phe Ser Pro Arg Ile Thr Pro Leu Lys Val Gln

215 220 225gct gct ttc cat cac cca gct atg aac atg gct gtg gag cag acc gtg 835Ala Ala Phe His His Pro Ala Met Asn Met Ala Val Glu Gln Thr Val230 235 240 245gcg tgg gca acc act gct ggt ttg gat gtg gaa ctc acc cgc gag atc 883Ala Trp Ala Thr Thr Ala Gly Leu Asp Val Glu Leu Thr Arg Glu Ile

250 255 260gcc gct gat gtt ttg gtt aac cct gtc gat tgg gta gca cgc gtc aac 931Ala Ala Asp Val Leu Val Asn Pro Val Asp Trp Val Ala Arg Val Asn

265 270 275gaa gcg tat gag gct ggc gct cgc tgg ttc ctc gac gtt gga cca gat 979Glu Ala Tyr Glu Ala Gly Ala Arg Trp Phe Leu Asp Val Gly Pro Asp

280 285 290ggt ggc atc gtt aag ctg act gcc aac atc ctt gag ggc cgc ggc gcg 1027Gly Gly Ile Val Lys Leu Thr Ala Asn Ile Leu Glu Gly Arg Gly Ala

295 300 305gat tcc ttc tat gtt ggt gac gcc gca ggc cag gcc aag ata ttt gat 1075Asp Ser Phe Tyr Val Gly Asp Ala Ala Gly Gln Ala Lys Ile Phe Asp310 315 320 325gct ggc atg gca cct gaa ctt cca gtg gat tac cag gag ttc gca cca 1123Ala Gly Met Ala Pro Glu Leu Pro Val Asp Tyr Gln Glu Phe Ala Pro

330 335 340cgc gtt gag cac gtt gat gga acc cca cgc ctg gtt acc aag ttc act 1171Arg Val Glu His Val Asp Gly Thr Pro Arg Leu Val Thr Lys Phe Thr

345 350 355gag ctg acc ggc cgc acc cca atg atg ctg gct ggc atg acc cca acc 1219Glu Leu Thr Gly Arg Thr Pro Met Met Leu Ala Gly Met Thr Pro Thr

360 365 370acc gtt gac cct gcc att gtt gca gcc gct gca aac ggt gga cac tgg 1267Thr Val Asp Pro Ala Ile Val Ala Ala Ala Ala Asn Gly Gly His Trp

375 380 385gct gag ctc gct ggt ggc gga cag gtt acc cca gag ctg ctg gaa acc 1315Ala Glu Leu Ala Gly Gly Gly Gln Val Thr Pro Glu Leu Leu Glu Thr390 395 400 405cac atc gca cag ctc acc gac atg ctt gag cca ggt atc aac gcc cag 1363His Ile Ala Gln Leu Thr Asp Met Leu Glu Pro Gly Ile Asn Ala Gln

410 415 420ttc aac tcc atg ttc ttg gat cca tac ctg tgg aag atg cag att ggt 1411Phe Asn Ser Met Phe Leu Asp Pro Tyr Leu Trp Lys Met Gln Ile Gly

425 430 435ggc aag cgc ctt gtt cct aag gcc cgc gct aat ggt gca tcc atc gac 1459Gly Lys Arg Leu Val Pro Lys Ala Arg Ala Asn Gly Ala Ser Ile Asp

440 445 450ggc atc gtc atc acc gcc ggc att cct gaa aag gat gaa gct gtt gca 1507Gly Ile Val Ile Thr Ala Gly Ile Pro Glu Lys Asp Glu Ala Val Ala

455 460 465ttg gtc aag gaa ctg atg cgt gat ggt ttc cct tgg atc gca ttc aag 1555Leu Val Lys Glu Leu Met Arg Asp Gly Phe Pro Trp Ile Ala Phe Lys470 475 480 485cca ggt gcc atc aag cag gtt aac tct gtg ttg gct atc gct aag gaa 1603Pro Gly Ala Ile Lys Gln Val Asn Ser Val Leu Ala Ile Ala Lys Glu

490 495 500gtt cca gaa ctc ccc atc atc att cag att gag ggt ggc gtt gca ggt 1651Val Pro Glu Leu Pro Ile Ile Ile Gln Ile Glu Gly Gly Val Ala Gly

505 510 515gga cac cac tct tgg gaa gac ctc gat gag ctg ctg atc gcc acc tac 1699Gly His His Ser Trp Glu Asp Leu Asp Glu Leu Leu Ile Ala Thr Tyr

520 525 530ggc aag gtc cgc gca ctg gat aac gtg gtg ctg tgt gtc ggc ggt ggc 1747Gly Lys Val Arg Ala Leu Asp Asn Val Val Leu Cys Val Gly Gly Gly

535 540 545att ggc tca cct gag cgc gct gct gat tac gtc acc ggt tcc tgg tcc 1795Ile Gly Ser Pro Glu Arg Ala Ala Asp Tyr Val Thr Gly Ser Trp Ser550 555 560 565act tcc tac ggc ctg cca gct atg cct gtt gat ggc atc ttg gtg ggt 1843Thr Ser Tyr Gly Leu Pro Ala Met Pro Val Asp Gly Ile Leu Val Gly

570 575 580acc gct gcg atg gca accaag gaa gca acc acc tcc cag gcc gtc aag 1891Thr Ala Ala Met Ala Thr Lys Glu Ala Thr Thr Ser Gln Ala Val Lys

585 590 595gaa ctt ctt gtt tcc acc cag ggc tct gat gaa tgg gtt cct gct ggt 1939Glu Leu Leu Val Ser Thr Gln Gly Ser Asp Glu Trp Val Pro Ala Gly

600 605 610ggc gca aag aac gga atg gca tct ggc cgt tcc cag ctt ggc gca gac 1987Gly Ala Lys Asn Gly Met Ala Ser Gly Arg Ser Gln Leu Gly Ala Asp

615 620 625atc cac gag atc gac aac tcc ttt gct aag gct gga cgc ctt ctt gat 2035Ile His Glu Ile Asp Asn Ser Phe Ala Lys Ala Gly Arg Leu Leu Asp630 635 640 645gag gtt gca ggc gat gag acg gct gtg cag gcg cgc cgg gat gag atc 2083Glu Val Ala Gly Asp Glu Thr Ala Val Gln Ala Arg Arg Asp Glu Ile

650 655 660att gaa gcg att ggc aag acc gcc aag gtg tac ttc ggt gac atc gga 2131Ile Glu Ala Ile Gly Lys Thr Ala Lys Val Tyr Phe Gly Asp Ile Gly

665 670 675tcc atg act tac gag cag tgg ctc aac cgc tac ctc gag ctg tct ggc 2179Ser Met Thr Tyr Glu Gln Trp Leu Asn Arg Tyr Leu Glu Leu Ser Gly

680 685 690cct gtt gat ggt cag tgg att gat gct tcc tgg gct gca cgt ttt gcc 2227Pro Val Asp Gly Gln Trp Ile Asp Ala Ser Trp Ala Ala Arg Phe Ala

695 700 705cag atg ctg gag cgt gcc gag gcg cgt ttg atc gag cag gat cat ggc 2275Gln Met Leu Glu Arg Ala Glu Ala Arg Leu Ile Glu Gln Asp His Gly710 715 720 725caa ttt gag cca agc ctg acg gtg gag gat ggc gtc gac aag ctt gtt 2323Gln Phe Glu Pro Ser Leu Thr Val Glu Asp Gly Val Asp Lys Leu Val

730 735 740gct gct tac ccg cat gcc gca acc gac ctg ctc acc ccg gct gat gtc 2371Ala Ala Tyr Pro His Ala Ala Thr Asp Leu Leu Thr Pro Ala Asp Val

745 750 755gcc tgg ttc ttg ggc ctg tgc cgc acg ccg ggc aag cct gtg aac ttt 2419Ala Trp Phe Leu Gly Leu Cys Arg Thr Pro Gly Lys Pro Val Asn Phe

760 765 770gtg ccc gtc att gat aag gac gtg cgt cgc tgg tgg cgc tcg gac tcc 2467Val Pro Val Ile Asp Lys Asp Val Arg Arg Trp Trp Arg Ser Asp Ser

775 780 785ctg tgg cag tcc cac gat gat cgc tac acc gct gat cag gtg gct att 2515Leu Trp Gln Ser His Asp Asp Arg Tyr Thr Ala Asp Gln Val Ala Ile790 795 800 805atc cct ggt gtc gtc gcc gtt gct ggc atc acc aag gcc aac gaa cct 2563Ile Pro Gly Val Val Ala Val Ala Gly Ile Thr Lys Ala Asn Glu Pro

810 815 820gtc gct gac ctg ctt gat cgc ttt gtc gac gcc acc atc gag cgc atc 2611Val Ala Asp Leu Leu Asp Arg Phe Val Asp Ala Thr Ile Glu Arg Ile

825 830 835gat gag cac gat tcc cgc tcc cgc gac atc atg ggc aaa gtg ctt tcc 2659Asp Glu His Asp Ser Arg Ser Arg Asp Ile Met Gly Lys Val Leu Ser

840 845 850tca cct ggc aca ttc tgg gct ggc cgc aac atc cca tcg gtg atc cac 2707Ser Pro Gly Thr Phe Trp Ala Gly Arg Asn Ile Pro Ser Val Ile His

855 860 865agc ctt ggg cat gct gac aag tgg tcc cgc tcc gaa ttc gaa gca ttc 2755Ser Leu Gly His Ala Asp Lys Trp Ser Arg Ser Glu Phe Glu Ala Phe870 875 880 885cat agc cca acc ggc gcc aac ttg gtg tac gaa gac gcc gag cac gcg 2803His Ser Pro Thr Gly Ala Asn Leu Val Tyr Glu Asp Ala Glu His Ala

890 895 900atg ctg act gtg cct ttg gcg ggt tcc acc gca ttc ggc acc acc gct 2851Met Leu Thr Val Pro Leu Ala Gly Ser Thr Ala Phe Gly Thr Thr Ala

905 910 915gag ctg aaa atc cgt ttc acc agc ccc atc gac gct ctg cca agc gct 2899Glu Leu Lys Ile Arg Phe Thr Ser Pro Ile Asp Ala Leu Pro Ser Ala

920 925 930gtc cca ctg gtc acc cag gaa gac gct gaa gcc gcg atg ggt gaa ctg 2947Val Pro Leu Val Thr Gln Glu Asp Ala Glu Ala Ala Met Gly Glu Leu

935 940 945acc cgc atc gca gct ggc ggc acc ctg gca act gtg aac aat ggc acc 2995Thr Arg Ile Ala Ala Gly Gly Thr Leu Ala Thr Val Asn Asn Gly Thr950 955 960 965gct acc tgg gaa acc tcc gtc gat gcc ggc gtc atc gct gac tac aac 3043Ala Thr Trp Glu Thr Ser Val Asp Ala Gly Val Ile Ala Asp Tyr Asn

970 975 980aac gtc acc gca ggc tac ctg cca gca tcc gtt gtt cct gca cac acc 3091Asn Val Thr Ala Gly Tyr Leu Pro Ala Ser Val Val Pro Ala His Thr

985 990 995gca cct gac gtg ctg gtt ggc cgc gca tgg cca gca gtt ttc gct gcc 3139Ala Pro Asp Val Leu Val Gly Arg Ala Trp Pro Ala Val Phe Ala Ala

1000 1005 1010gta aag tcc gca gtc atc cca ggc acc gat tcc gca tcc gtt gtg gaa 3187Val Lys Ser Ala Val Ile Pro Gly Thr Asp Ser Ala Ser Val Val Glu

1015 1020 1025ggc atg ctg tcc ctg gtt cac ctg gag cac cac att gtg ctc aag tcc 3235Gly Met Leu Ser Leu Val His Leu Glu His His Ile Val LeuLys Ser1030 1035 1040 1045gat gtc cca acc gac ggc gcg ctg aag gtt tcc gcg act gcc gat gag 3283Asp Val Pro Thr Asp Gly Ala Leu Lys Val Ser Ala Thr Ala Asp Glu

1050 1055 1060gta gtc gat acc gac ctg ggt cgc ctc gtg atc gtg cgc gca gaa atc 3331Val Val Asp Thr Asp Leu Gly Arg Leu Val Ile Val Arg Ala Glu Ile

1065 1070 1075gcc gac gca gaa ggc aac ctg att gct acg ttg gct gag cgt ttc gcg 3379Ala Asp Ala Glu Gly Asn Leu Ile Ala Thr Leu Ala Glu Arg Phe Ala

1080 1085 1090atc cgc gga cgc aag ggc aac gct gtc gca cgc acc aac acc tcc gca 3427Ile Arg Gly Arg Lys Gly Asn Ala Val Ala Arg Thr Asn Thr Ser Ala

1095 1100 1105ctg cca acc acc gtg gac acc cca cgc tca gct cgc gca gtg gca acc 3475Leu Pro Thr Thr Val Asp Thr Pro Arg Ser Ala Arg Ala Val Ala Thr1110 1115 1120 1125gtt gtt gca cct gaa tcc atg cgc cca ttc gct gtg atc tcc ggt gac 3523Val Val Ala Pro Glu Ser Met Arg Pro Phe Ala Val Ile Ser Gly Asp

1130 1135 1140cgc aac cca att cac gtc tct gat gtt gcg gct tcc ctg gct ggt ctg 3571Arg Asn Pro Ile His Val Ser Asp Val Ala Ala Ser Leu Ala Gly Leu

1145 1150 1155cca ggt gtg atc gtg cac ggc atg tgg acc tct gcc atc ggt gaa ctg 3619Pro Gly Val Ile Val His Gly Met Trp Thr Ser Ala Ile Gly Glu Leu

1160 1165 1170atc gcc ggt gca gca ttc aac gat gag cag atc caa act ccc gca gcc 3667Ile Ala Gly Ala Ala Phe Asn Asp Glu Gln Ile Gln Thr Pro Ala Ala

1175 1180 1185aaggtc gtg gaa tac acc gca acc atg ctg gca cca gtt ctt cca ggt 3715Lys Val Val Glu Tyr Thr Ala Thr Met Leu Ala Pro Val Leu Pro Gly1190 1195 1200 1205gaa gaa att gag ttc agc gtt gag cgc tcc gca gtg gac aac cgc cca 3763Glu Glu Ile Glu Phe Ser Val Glu Arg Ser Ala Val Asp Asn Arg Pro

1210 1215 1220gga atg gga gag gtc cgc acc gtt acc gca acc gtc aac ggc aac tta 3811Gly Met Gly Glu Val Arg Thr Val Thr Ala Thr Val Asn Gly Asn Leu

1225 1230 1235gtg ctt acc gcc acc gct gtt gtg gca gct cca tct act ttc tac gca 3859Val Leu Thr Ala Thr Ala Val Val Ala Ala Pro Ser Thr Phe Tyr Ala

1240 1245 1250ttc cca ggc cag ggc att cag tcc cag ggc atg ggt atg gaa gca cgc 3907Phe Pro Gly Gln Gly Ile Gln Ser Gln Gly Met Gly Met Glu Ala Arg

1255 1260 1265cgt aac tct cag gca gct cgc gct atc tgg gac cgc gcc gat gca cac 3955Arg Asn Ser Gln Ala Ala Arg Ala Ile Trp Asp Arg Ala Asp Ala His1270 1275 1280 1285acc cgc aat aag ctg ggc ttc tcc atc gtg gaa atc gtg gaa aac aac 4003Thr Arg Asn Lys Leu Gly Phe Ser Ile Val Glu Ile Val Glu Asn Asn

1290 1295 1300cca cgc gaa gta acc gtg gca ggg gag aag ttc ttc cac cca gac ggc 4051Pro Arg Glu Val Thr Val Ala Gly Glu Lys Phe Phe His Pro Asp Gly

1305 1310 1315gtt ttg tac ctc acc cag ttc acc cag gtg ggc atg gca act ctg ggc 4099Val Leu Tyr Leu Thr Gln Phe Thr Gln Val Gly Met Ala Thr Leu Gly

1320 1325 1330gtt gct cag atc gct gaa atg cgt gaa gca cat gcc ttg aac cag cgt 4147Val Ala Gln Ile Ala Glu Met Arg Glu Ala His Ala Leu Asn Gln Arg

1335 1340 1345gca tac ttt gct gga cac tcc gtt ggt gag tac aac gcg ctt gct gca 4195Ala Tyr Phe Ala Gly His Ser Val Gly Glu Tyr Asn Ala Leu Ala Ala1350 1355 1360 1365tat gct ggt gtg ctg tcc ctg gaa tcc gtt ctg gag atc gtt tac cgt 4243Tyr Ala Gly Val Leu Ser Leu Glu Ser Val Leu Glu Ile Val Tyr Arg

1370 1375 1380cgt ggc ttg acc atg cac cgc ttg gtg gat cgc gat gaa aac ggt ctg 4291Arg Gly Leu Thr Met His Arg Leu Val Asp Arg Asp Glu Asn Gly Leu

1385 1390 1395tcc aac tac gcg ctc gca gct ctt cgc ccc aac aag atg ggt ctg acc 4339Ser Asn Tyr Ala Leu Ala Ala Leu Arg Pro Asn Lys Met Gly Leu Thr

1400 1405 1410gca gac aac gtt ttc gat tac gtt gcg tct gtt tcc gaa gct tcc ggt 4387Ala Asp Asn Val Phe Asp Tyr Val Ala Ser Val Ser Glu Ala Ser Gly

1415 1420 1425gaa ttc ctg gag atc gtt aac tac aac ttg gct ggc ctg cag tac gca 4435Glu Phe Leu Glu Ile Val Asn Tyr Asn Leu Ala Gly Leu Gln Tyr Ala1430 1435 1440 1445gtt gct gga acc cag gct ggt ctt gcc gcc ctt cgt gcc gat gtt gag 4483Val Ala Gly Thr Gln Ala Gly Leu Ala Ala Leu Arg Ala Asp Val Glu

1450 1455 1460aac cgt gca cca ggt cag cgt gcc ttc att ttg atc cct ggc att gac 4531Asn Arg Ala Pro Gly Gln Arg Ala Phe Ile Leu Ile Pro Gly Ile Asp

1465 1470 1475gtg cca ttc cac tcc tcc aag ctg cgc gac ggt gtg ggc gcg ttc cgt 4579Val Pro Phe His Ser Ser Lys Leu Arg Asp Gly Val Gly Ala Phe Arg

1480 1485 1490gag cac ctt gat tcc ctg atc cca gct gag ctg gat ctg gat gtg ctg 4627Glu His Leu Asp Ser Leu Ile Pro Ala Glu Leu Asp Leu Asp Val Leu

1495 1500 1505gtt ggc cgc tac att cca aac ttg gtg gct cgc cca ttc gaa ctc act 4675Val Gly Arg Tyr Ile Pro Asn Leu Val Ala Arg Pro Phe Glu Leu Thr1510 1515 1520 1525gaa gag ttc gtg gca tcc atg gca gaa gtg gtg gag tcc acc tat gtc 4723Glu Glu Phe Val Ala Ser Met Ala Glu Val Val Glu Ser Thr Tyr Val

1530 1535 1540aat gag atc ttg gct gat ttc aag gct gct tcc gcc gat aag cag aag 4771Asn Glu Ile Leu Ala Asp Phe Lys Ala Ala Ser Ala Asp Lys Gln Lys

1545 1550 1555ctt gcc cgc acg ttg ctt att gag ctg ctt gca tgg cag ttc gca tca 4819Leu Ala Arg Thr Leu Leu Ile Glu Leu Leu Ala Trp Gln Phe Ala Ser

1560 1565 1570cct gtg cgc tgg atc gag act cag gat ctg ttg atc aag ggc ctt caa 4867Pro Val Arg Trp Ile Glu Thr Gln Asp Leu Leu Ile Lys Gly Leu Gln

1575 1580 1585gct gag cgt ttc gtg gag gtc ggt gtt ggc tct gct cca acg ctt gcc 4915Ala Glu Arg Phe Val Glu Val Gly Val Gly Ser Ala Pro Thr Leu Ala1590 1595 1600 1605aac atg atg ggc cag acc ctg cgc ctt cct cag tac gcg gac gcc acc 4963Asn Met Met Gly Gln Thr Leu Arg Leu Pro Gln Tyr Ala Asp Ala Thr

1610 1615 1620att gag gtg tta aac att gag cgc gat cgc cca gtt gtg ttc gct acc 5011Ile Glu Val Leu Asn Ile Glu Arg Asp Arg Pro Val Val Phe Ala Thr

1625 1630 1635gat gag gtt gtg cgt gaa gtg gcg gtt gaa gag acc cca gca gct cct 5059Asp Glu Val Val Arg Glu Val Ala Val Glu Glu ThrPro Ala Ala Pro

1640 1645 1650gca gaa acc act gaa acc cca gca acc cca gca acc cca gcc cct gtt 5107Ala Glu Thr Thr Glu Thr Pro Ala Thr Pro Ala Thr Pro Ala Pro Val

1655 1660 1665gca gct gca gcc cct gcc acc ggc ggc cct cgc cca gat gac atc agc 5155Ala Ala Ala Ala Pro Ala Thr Gly Gly Pro Arg Pro Asp Asp Ile Ser1670 1675 1680 1685ttc act cct tct gat gcc act gaa atg ctc atc gct atc tgg acc aag 5203Phe Thr Pro Ser Asp Ala Thr Glu Met Leu Ile Ala Ile Trp Thr Lys

1690 1695 1700gtt cgc cca gat cag atg ggt gcc act gat tcc atc gag acc ctg gtt 5251Val Arg Pro Asp Gln Met Gly Ala Thr Asp Ser Ile Glu Thr Leu Val

1705 1710 1715gag ggc gtg tcc tct cgc cgt aac cag ctc ctg ctg gat ctt ggt gtg 5299Glu Gly Val Ser Ser Arg Arg Asn Gln Leu Leu Leu Asp Leu Gly Val

1720 1725 1730gag ttc ggc ctc ggc gca att gac gga gca gcc gat gct gag ctc ggt 5347Glu Phe Gly Leu Gly Ala Ile Asp Gly Ala Ala Asp Ala Glu Leu Gly

1735 1740 1745gat cta aag gtc acc gtg tcc aag atg gct aag ggc tac aag gcg ttt 5395Asp Leu Lys Val Thr Val Ser Lys Met Ala Lys Gly Tyr Lys Ala Phe1750 1755 1760 1765ggc cct gtg ctc tcc gat gct gca gct gat gcc ctg cgt cgc ctc act 5443Gly Pro Val Leu Ser Asp Ala Ala Ala Asp Ala Leu Arg Arg Leu Thr

1770 1775 1780ggt cct acc ggt aag cgc ccg gga tac atc gca gag cgc gtc acc ggc 5491Gly Pro Thr Gly Lys Arg Pro Gly Tyr Ile Ala Glu Arg Val Thr Gly

1785 1790 1795acg tgg gaa ttg ggc cag ggc tgg gct gac cac gtg gtc gct gaa gtt 5539Thr Trp Glu Leu Gly Gln Gly Trp Ala Asp His Val Val Ala Glu Val

1800 1805 1810gtg atc ggc gcc cgc gaa ggc gca tcc ctg cgc ggc ggc gac ctg gcg 5587Val Ile Gly Ala Arg Glu Gly Ala Ser Leu Arg Gly Gly Asp Leu Ala

1815 1820 1825tca ctg tct cct gca agc cca gcg tct gca tca gat ctt gat tcg ctt 5635Ser Leu Ser Pro Ala Ser Pro Ala Ser Ala Ser Asp Leu Asp Ser Leu1830 1835 1840 1845atc gac gca gcc gtc cag gcc gta gcc tcc cgc cgc ggc gtt gcg gtc 5683Ile Asp Ala Ala Val Gln Ala Val Ala Ser Arg Arg Gly Val Ala Val

1850 1855 1860tcc ctg cct tca gca ggc ggc gct gcc ggt ggc gtg gtt gat tcc gca 5731Ser Leu Pro Ser Ala Gly Gly Ala Ala Gly Gly Val Val Asp Ser Ala

1865 1870 1875gct ctt ggc gag ttt gca gag cag gtc acc gga cac gat ggt gtg ctt 5779Ala Leu Gly Glu Phe Ala Glu Gln Val Thr Gly His Asp Gly Val Leu

1880 1885 1890gct cag gca gcc cgc acc atc ttg acc cag ttg ggt ctt gat aag cca 5827Ala Gln Ala Ala Arg Thr Ile Leu Thr Gln Leu Gly Leu Asp Lys Pro

1895 1900 1905gca acc gtt tcc gtg gaa gac acc gca gag gaa gac ctc tac gag ttg 5875Ala Thr Val Ser Val Glu Asp Thr Ala Glu Glu Asp Leu Tyr Glu Leu1910 1915 1920 1925gtc tcc aag gaa ctc ggt tct gat tgg cca cgt cag gtt gca cca agc 5923Val Ser Lys Glu Leu Gly Ser Asp Trp Pro Arg Gln Val Ala Pro Ser

1930 1935 1940ttc gat gaa gaa aag gtt gtt ctg ctt gat gac cgt tgg gct tct gcg 5971Phe Asp Glu Glu Lys Val Val Leu Leu Asp Asp Arg Trp Ala Ser Ala

1945 1950 1955cgt gag gat ctc tcc gcg ttg ctc ttg gcg aac tcg cag caa ctg ata 6019Arg Glu Asp Leu Ser Ala Leu Leu Leu Ala Asn Ser Gln Gln Leu Ile

1960 1965 1970tcg atg tca cag gcg cag gcg aag ctg ttg cag cac aag ctg aat tct 6067Ser Met Ser Gln Ala Gln Ala Lys Leu Leu Gln His Lys Leu Asn Ser

1975 1980 1985ttg gac ttg atg atc tcg cag cta ggc tcg cga aca aag ctt ctt gga 6115Leu Asp Leu Met Ile Ser Gln Leu Gly Ser Arg Thr Lys Leu Leu Gly1990 1995 2000 2005cta cgc cga caa tgt tgc ggc 6136Leu Arg Arg Gln Cys Cys Gly

2010<210>50<211>2012<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>50Leu Lys Thr Leu Arg Ala Ala Val Ala Ala Gly Ala Gly Thr Asn Val 151015 Ser Asp Ile Val Glu Arg Ala Asn Ala Leu Leu Ala Leu Val Ala Asp

20 25 30Asp Leu Ile Gly Thr Leu Pro Phe Gly Phe Asp Pro Val Ala Trp Ala

35 40 45Asn Asn Ser Glu Asp Pro Ala Phe Asp Thr Ala Gln Ser Ala Val Ser

50 55 60Val Pro Gly Ile Phe Val Ser Gln Ile Ala Thr Leu Asp Ser Leu Glu 65 70 75 80Ala Gln Arg Leu Asp Val Asp Gln Ala Val Ser Ser Ile Gly His Ser

85 90 95Gln Gly Val Leu Gly Val His Leu Leu Asn Asp Ala Thr Arg Ala Asp

100 105 110Glu Leu Val Ala Ile Ala Gln Leu Ile Gly Ala Ala Ile Thr Arg Thr

115120 125Ala Arg Met Thr Gly Leu Ile Ala Gln Gly Asp Asn Met Pro Met Leu

130 135 140Ser Ile Ala Gly Ile Ser Arg Glu Gln Leu Gln Gln Ala Ile Asp Ala145 150 155 160Ala Cys Ala Glu Val Pro Ala Glu Ile Arg Pro Val Ile Gly Leu Arg

165 170 175Asn Ser Arg Asp Ser Tyr Val Leu Val Gly Arg Pro Asp Asp Asn Ala

180 185 190Arg Val Val Lys Val Ile Glu Ala Met Ala Ala Lys Asp Lys Lys Ala

195 200 205Ile Glu Asp Lys Leu Arg Gly Gly Ser Ala Phe Ser Pro Arg Ile Thr

210 215 220Pro Leu Lys Val Gln Ala Ala Phe His His Pro Ala Met Asn Met Ala225 230 235 240Val Glu Gln Thr Val Ala Trp Ala Thr Thr Ala Gly Leu Asp Val Glu

245 250 255Leu Thr Arg Glu Ile Ala Ala Asp Val Leu Val Asn Pro Val Asp Trp

260 265 270Val Ala Arg Val Asn Glu Ala Tyr Glu Ala Gly Ala Arg Trp Phe Leu

275 280 285Asp Val Gly Pro Asp Gly Gly Ile Val Lys Leu Thr Ala Asn Ile Leu

290 295 300Glu Gly Arg Gly Ala Asp Ser Phe Tyr Val Gly Asp Ala Ala Gly Gln305 310 315 320Ala Lys Ile Phe Asp Ala Gly Met Ala Pro Glu Leu Pro Val Asp Tyr

325 330 335Gln Glu Phe Ala Pro Arg Val Glu His Val Asp Gly Thr Pro Arg Leu

340 345 350Val Thr LysPhe Thr Glu Leu Thr Gly Arg Thr Pro Met Met Leu Ala

355 360 365Gly Met Thr Pro Thr Thr Val Asp Pro Ala Ile Val Ala Ala Ala Ala

370 375 380Asn Gly Gly His Trp Ala Glu Leu Ala Gly Gly Gly Gln Val Thr Pro385 390 395 400Glu Leu Leu Glu Thr His Ile Ala Gln Leu Thr Asp Met Leu Glu Pro

405 410 415Gly Ile Asn Ala Gln Phe Asn Ser Met Phe Leu Asp Pro Tyr Leu Trp

420 425 430Lys Met Gln Ile Gly Gly Lys Arg Leu Val Pro Lys Ala Arg Ala Asn

435 440 445Gly Ala Ser Ile Asp Gly Ile Val Ile Thr Ala Gly Ile Pro Glu Lys

450 455 460Asp Glu Ala Val Ala Leu Val Lys Glu Leu Met Arg Asp Gly Phe Pro465 470 475 480Trp Ile Ala Phe Lys Pro Gly Ala Ile Lys Gln Val Asn Ser Val Leu

485 490 495Ala Ile Ala Lys Glu Val Pro Glu Leu Pro Ile Ile Ile Gln Ile Glu

500 505 510Gly Gly Val Ala Gly Gly His His Ser Trp Glu Asp Leu Asp Glu Leu

515 520 525Leu Ile Ala Thr Tyr Gly Lys Val Arg Ala Leu Asp Asn Val Val Leu

530 535 540Cys Val Gly Gly Gly Ile Gly Ser Pro Glu Arg Ala Ala Asp Tyr Val545 550 555 560Thr Gly Ser Trp Ser Thr Ser Tyr Gly Leu Pro Ala Met Pro Val Asp

565 570 575Gly Ile Leu Val Gly Thr Ala Ala Met Ala Thr Lys Glu Ala Thr Thr

580 585 590Ser Gln Ala Val Lys Glu Leu Leu Val Ser Thr Gln Gly Ser Asp Glu

595 600 605Trp Val Pro Ala Gly Gly Ala Lys Asn Gly Met Ala Ser Gly Arg Ser

610 615 620Gln Leu Gly Ala Asp Ile His Glu Ile Asp Asn Ser Phe Ala Lys Ala625 630 635 640Gly Arg Leu Leu Asp Glu Val Ala Gly Asp Glu Thr Ala Val Gln Ala

645 650 655Arg Arg Asp Glu Ile Ile Glu Ala Ile Gly Lys Thr Ala Lys Val Tyr

660 665 670Phe Gly Asp Ile Gly Ser Met Thr Tyr Glu Gln Trp Leu Asn Arg Tyr

675 680 685Leu Glu Leu Ser Gly Pro Val Asp Gly Gln Trp Ile Asp Ala Ser Trp

690 695 700Ala Ala Arg Phe Ala Gln Met Leu Glu Arg Ala Glu Ala Arg Leu Ile705 710 715 720Glu Gln Asp His Gly Gln Phe Glu Pro Ser Leu Thr Val Glu Asp Gly

725 730 735Val Asp Lys Leu Val Ala Ala Tyr Pro His Ala Ala Thr Asp Leu Leu

740 745 750Thr Pro Ala Asp Val Ala Trp Phe Leu Gly Leu Cys Arg Thr Pro Gly

755 760 765Lys Pro Val Asn Phe Val Pro Val Ile Asp Lys Asp Val Arg Arg Trp

770 775 780Trp Arg Ser Asp Ser Leu Trp Gln Ser His Asp Asp Arg Tyr Thr Ala785 790 795 800Asp Gln Val Ala Ile Ile Pro Gly Val Val Ala Val Ala Gly Ile Thr

805 810 815Lys Ala Asn Glu Pro Val Ala Asp Leu Leu Asp Arg Phe Val Asp Ala

820 825 830Thr Ile Glu Arg Ile Asp Glu His Asp Ser Arg Ser Arg Asp Ile Met

835 840 845Gly Lys Val Leu Ser Ser Pro Gly Thr Phe Trp Ala Gly Arg Asn Ile

850 855 860Pro Ser Val Ile His Ser Leu Gly His Ala Asp Lys Trp Ser Arg Ser865 870 875 880Glu Phe Glu Ala Phe His Ser Pro Thr Gly Ala Asn Leu Val Tyr Glu

885 890 895Asp Ala Glu His Ala Met Leu Thr Val Pro Leu Ala Gly Ser Thr Ala

900 905 910Phe Gly Thr Thr Ala Glu Leu Lys Ile Arg Phe Thr Ser Pro Ile Asp

915 920 925Ala Leu Pro Ser Ala Val Pro Leu Val Thr Gln Glu Asp Ala Glu Ala

930 935 940Ala Met Gly Glu Leu Thr Arg Ile Ala Ala Gly Gly Thr Leu Ala Thr945 950 955 960Val Asn Asn Gly Thr Ala Thr Trp Glu Thr Ser Val Asp Ala Gly Val

965 970 975Ile Ala Asp Tyr Asn Asn Val Thr Ala Gly Tyr Leu Pro Ala Ser Val

980 985 990Val Pro Ala His Thr Ala Pro Asp Val Leu Val Gly Arg Ala Trp Pro

995 1000 1005Ala Val Phe Ala Ala Val Lys Ser Ala Val Ile Pro Gly Thr Asp Ser

1010 1015 1020Ala Ser Val Val Glu Gly Met Leu Ser Leu Val His Leu Glu His His1025 1030 1035 1040Ile Val Leu Lys Ser Asp Val Pro Thr Asp Gly Ala Leu Lys Val Ser

1045 1050 1055Ala Thr Ala Asp Glu Val Val Asp Thr Asp Leu Gly Arg Leu Val Ile

1060 1065 1070Val Arg Ala Glu Ile Ala Asp Ala Glu Gly Asn Leu Ile Ala Thr Leu

1075 1080 1085Ala Glu Arg Phe Ala Ile Arg Gly Arg Lys Gly Asn Ala Val Ala Arg

1090 1095 1100Thr Asn Thr Ser Ala Leu Pro Thr Thr Val Asp Thr Pro Arg Ser Ala1105 1110 1115 1120Arg Ala Val Ala Thr Val Val Ala Pro Glu Ser Met Arg Pro Phe Ala

1125 1130 1135Val Ile Ser Gly Asp Arg Asn Pro Ile His Val Ser Asp Val Ala Ala

1140 1145 1150Ser Leu Ala Gly Leu Pro Gly Val Ile Val His Gly Met Trp Thr Ser

1155 1160 1165Ala Ile Gly Glu Leu Ile Ala Gly Ala Ala Phe Asn Asp Glu Gln Ile

1170 1175 1180Gln Thr Pro Ala Ala Lys Val Val Glu Tyr Thr Ala Thr Met Leu Ala1185 1190 1195 1200Pro Val Leu Pro Gly Glu Glu Ile Glu Phe Ser Val Glu Arg Ser Ala

1205 1210 1215Val Asp Asn Arg Pro Gly Met Gly Glu Val Arg Thr Val Thr Ala Thr

1220 1225 1230Val Asn Gly Asn Leu Val Leu Thr Ala Thr Ala Val Val Ala Ala Pro

1235 1240 1245Ser Thr Phe Tyr Ala Phe Pro Gly Gln Gly Ile Gln SerGln Gly Met

1250 1255 1260Gly Met Glu Ala Arg Arg Asn Ser Gln Ala Ala Arg Ala Ile Trp Asp1265 1270 1275 1280Arg Ala Asp Ala His Thr Arg Asn Lys Leu Gly Phe Ser Ile Val Glu

1285 1290 1295Ile Val Glu Asn Asn Pro Arg Glu Val Thr Val Ala Gly Glu Lys Phe

1300 1305 1310Phe His Pro Asp Gly Val Leu Tyr Leu Thr Gln Phe Thr Gln Val Gly

1315 1320 1325Met Ala Thr Leu Gly Val Ala Gln Ile Ala Glu Met Arg Glu Ala His

1330 1335 1340Ala Leu Asn Gln Arg Ala Tyr Phe Ala Gly His Ser Val Gly Glu Tyr1345 1350 1355 1360Asn Ala Leu Ala Ala Tyr Ala Gly Val Leu Ser Leu Glu Ser Val Leu

1365 1370 1375Glu Ile Val Tyr Arg Arg Gly Leu Thr Met His Arg Leu Val Asp Arg

1380 1385 1390Asp Glu Asn Gly Leu Ser Asn Tyr Ala Leu Ala Ala Leu Arg Pro Asn

1395 1400 1405Lys Met Gly Leu Thr Ala Asp Asn Val Phe Asp Tyr Val Ala Ser Val

1410 1415 1420Ser Glu Ala Ser Gly Glu Phe Leu Glu Ile Val Asn Tyr Asn Leu Ala1425 1430 1435 1440Gly Leu Gln Tyr Ala Val Ala Gly Thr Gln Ala Gly Leu Ala Ala Leu

1445 1450 1455Arg Ala Asp Val Glu Asn Arg Ala Pro Gly Gln Arg Ala Phe Ile Leu

1460 1465 1470Ile Pro Gly Ile Asp Val Pro Phe His Ser Ser Lys Leu Arg Asp Gly

1475 1480 1485Val Gly Ala Phe Arg Glu His Leu Asp Ser Leu Ile Pro Ala Glu Leu

1490 1495 1500Asp Leu Asp Val Leu Val Gly Arg Tyr Ile Pro Asn Leu Val Ala Arg1505 1510 1515 1520Pro Phe Glu Leu Thr Glu Glu Phe Val Ala Ser Met Ala Glu Val Val

1525 1530 1535Glu Ser Thr Tyr Val Asn Glu Ile Leu Ala Asp Phe Lys Ala Ala Ser

1540 1545 1550Ala Asp Lys Gln Lys Leu Ala Arg Thr Leu Leu Ile Glu Leu Leu Ala

1555 1560 1565Trp Gln Phe Ala Ser Pro Val Arg Trp Ile Glu Thr Gln Asp Leu Leu

1570 1575 1580Ile Lys Gly Leu Gln Ala Glu Arg Phe Val Glu Val Gly Val Gly Ser1585 1590 1595 1600Ala Pro Thr Leu Ala Asn Met Met Gly Gln Thr Leu Arg Leu Pro Gln

1605 1610 1615Tyr Ala Asp Ala Thr Ile Glu Val Leu Asn Ile Glu Arg Asp Arg Pro

1620 1625 1630Val Val Phe Ala Thr Asp Glu Val Val Arg Glu Val Ala Val Glu Glu

1635 1640 1645Thr Pro Ala Ala Pro Ala Glu Thr Thr Glu Thr Pro Ala Thr Pro Ala

1650 1655 1660Thr Pro Ala Pro Val Ala Ala Ala Ala Pro Ala Thr Gly Gly Pro Arg1665 1670 1675 1680Pro Asp Asp Ile Ser Phe Thr Pro Ser Asp Ala Thr Glu Met Leu Ile

1685 1690 1695Ala Ile Trp Thr Lys Val Arg Pro Asp Gln Met Gly Ala Thr Asp Ser

1700 1705 1710Ile Glu Thr Leu Val Glu Gly Val Ser Ser Arg Arg Asn Gln Leu Leu

1715 1720 1725Leu Asp Leu Gly Val Glu Phe Gly Leu Gly Ala Ile Asp Gly Ala Ala

1730 1735 1740Asp Ala Glu Leu Gly Asp Leu Lys Val Thr Val Ser Lys Met Ala Lys1745 1750 1755 1760Gly Tyr Lys Ala Phe Gly Pro Val Leu Ser Asp Ala Ala Ala Asp Ala

1765 1770 1775Leu Arg Arg Leu Thr Gly Pro Thr Gly Lys Arg Pro Gly Tyr Ile Ala

1780 1785 1790Glu Arg Val Thr Gly Thr Trp Glu Leu Gly Gln Gly Trp Ala Asp His

1795 1800 1805Val Val Ala Glu Val Val Ile Gly Ala Arg Glu Gly Ala Ser Leu Arg

1810 1815 1820Gly Gly Asp Leu Ala Ser Leu Ser Pro Ala Ser Pro Ala Ser Ala Ser1825 1830 1835 1840Asp Leu Asp Ser Leu Ile Asp Ala Ala Val Gln Ala Val Ala Ser Arg

1845 l850 1855Arg Gly Val Ala Val Ser Leu Pro Ser Ala Gly Gly Ala Ala Gly Gly

1860 1865 1870Val Val Asp Ser Ala Ala Leu Gly Glu Phe Ala Glu Gln Val Thr Gly

1875 1880 1885His Asp Gly Val Leu Ala Gln Ala Ala Arg Thr Ile Leu Thr Gln Leu

1890 1895 1900Gly Leu Asp Lys Pro Ala Thr Val Ser Val Glu Asp Thr Ala Glu Glu1905 1910 1915 1920Asp Leu Tyr Glu Leu Val Ser Lys Glu Leu Gly Ser Asp Trp Pro Arg

1925 1930 1935Gln Val Ala Pro Ser Phe Asp Glu Glu Lys Val Val Leu Leu Asp Asp

1940 1945 1950Arg Trp Ala Ser Ala Arg Glu Asp Leu Ser Ala Leu Leu Leu Ala Asn

1955 1960 1965Ser Gln Gln Leu Ile Ser Met Ser Gln Ala Gln Ala Lys Leu Leu Gln

1970 1975 1980His Lys Leu Asn Ser Leu Asp Leu Met Ile Ser Gln Leu Gly Ser Arg1985 1990 1995 2000Thr Lys Leu Leu Gly Leu Arg Arg Gln Cys Cys Gly

20052010<210>5l<211>2185<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (2185)<223>FRXA00158<400>51cgtgccattt tctttacaaa agagtattaa ccgaaacttc aggtcaggat ccacgccctg 60cgttcatccc ggctaagtta tacaaggagc gagttctcac gtg acc gaa ttg agc 115

Val Thr Glu Leu Ser

1 5agg aac ttc ggg gcc agc cga ctg att aac cgc ttt ggc cag gag cct 163Arg Asn Phe Gly Ala Ser Arg Leu Ile Asn Arg Phe Gly Gln Glu Pro

10 15 20ttt gcc ttc gct ttc gcc ggc caa gga tat gac tgg ttg aag acc ctt 211Phe Ala Phe Ala Phe Ala Gly Gln Gly Tyr Asp Trp Leu Lys Thr Leu

25 30 35cgt gcc gcg gtt gcc gca ggt gca ggc acc aat gtt agt gac atc gtc 259Arg Ala Ala Val Ala Ala Gly Ala Gly Thr Asn Val Ser Asp Ile Val

40 45 50gag cgc gca aat gcg ctg ctt gca cta gtt gca gat gat ctc att ggc 307Glu Arg Ala Asn Ala Leu Leu AlaLeu Val Ala Asp Asp Leu Ile Gly

55 60 65acc ctt cca ttt ggt ttc gat cca gtg gct tgg gct aac aac tcc gaa 355Thr Leu Pro Phe Gly Phe Asp Pro Val Ala Trp Ala Asn Asn Ser Glu 70 75 80 85gat cca gct ttc gat act gca caa tct gca gtg agc gtg ccg ggt atc 403Asp Pro Ala Phe Asp Thr Ala Gln Ser Ala Val Ser Val Pro Gly Ile

90 95 100ttt gtc tcc cag atc gca acc ctg gat tcc ctt gag gcg cag cgc ctt 451Phe Val Ser Gln Ile Ala Thr Leu Asp Ser Leu Glu Ala Gln Arg Leu

105 110 115gat gtg gat cag gct gtg tcc agc att ggt cat tcc cag ggc gta ttg 499Asp Val Asp Gln Ala Val Ser Ser Ile Gly His Ser Gln Gly Val Leu

120 125 130ggc gtg cac ctg ctc aat gat gcg act cgt gct gat gaa ctc gtt gcc 547Gly Val His Leu Leu Asn Asp Ala Thr Arg Ala Asp Glu Leu Val Ala

135 140 145att gcg cag ttg atc ggt gca gcg atc acc cgc acc gca cgc atg acg 595Ile Ala Gln Leu Ile Gly Ala Ala Ile Thr Arg Thr Ala Arg Met Thr150 155 160 165ggc ctg atc gcg cag ggc gac aac atg ccg atg ctg tcg atc gcc gga 643Gly Leu Ile Ala Gln Gly Asp Asn Met Pro Met Leu Ser Ile Ala Gly

170 175 180att tcc cgc gaa cag ctt cag caa gct atc gac gcg gcc tgc gcc gaa 691Ile Ser Arg Glu Gln Leu Gln Gln Ala Ile Asp Ala Ala Cys Ala Glu

185 190 195gtc cct gcg gag atc cgc ccg gtt atc ggt ctg cgc aac tca cgc gat 739Val Pro Ala Glu Ile Arg Pro Val Ile Gly Leu Arg Asn Ser Arg Asp

200 205210tct tat gtt ttg gtt ggc cgc cca gac gac aac gct cgc gtt gtt aag 787Ser Tyr Val Leu Val Gly Arg Pro Asp Asp Asn Ala Arg Val Val Lys

215 220 225gtc att gag gca atg gct gcc aag gat aag aag gcc att gaa gat aag 835Val Ile Glu Ala Met Ala Ala Lys Asp Lys Lys Ala Ile Glu Asp Lys230 235 240 245ctg cgc ggc ggt tcc gcg ttc agc ccc cgt att act ccg ctg aag gtg 883Leu Arg Gly Gly Ser Ala Phe Ser Pro Arg Ile Thr Pro Leu Lys Val

250 255 260cag gct gct ttc cat cac cca gct atg aac atg gct gtg gag cag acc 931Gln Ala Ala Phe His His Pro Ala Met Asn Met Ala Val Glu Gln Thr

265 270 275gtg gcg tgg gca acc act gct ggt ttg gat gtg gaa ctc acc cgc gag 979Val Ala Trp Ala Thr Thr Ala Gly Leu Asp Val Glu Leu Thr Arg Glu

280 285 290atc gcc gct gat gtt ttg gtt aac cct gtc gat tgg gta gca cgc gtc 1027Ile Ala Ala Asp Val Leu Val Asn Pro Val Asp Trp Val Ala Arg Val

295 300 305aac gaa gcg tat gag gct ggc gct cgc tgg ttc ctc gac gtt gga cca 1075Asn Glu Ala Tyr Glu Ala Gly Ala Arg Trp Phe Leu Asp Val Gly Pro310 315 320 325gat ggt ggc atc gtt aag ctg act gcc aac atc ctt gag ggc cgc ggc 1123Asp Gly Gly Ile Val Lys Leu Thr Ala Asn Ile Leu Glu Gly Arg Gly

330 335 340gcg gat tcc ttc tat gtt ggt gac gcc gca ggc cag gcc aag ata ttt 1171Ala Asp Ser Phe Tyr Val Gly Asp Ala Ala Gly Gln Ala Lys Ile Phe

345 350 355gat gct ggc atg gca cct gaa ctt cca gtg gat tac cag gag ttc gca 1219Asp Ala Gly Met Ala Pro Glu Leu Pro Val Asp Tyr Gln Glu PheAla

360 365 370cca cgc gtt gag cac gtt gat gga acc cca cgc ctg gtt acc aag ttc 1267Pro Arg Val Glu His Val Asp Gly Thr Pro Arg Leu Val Thr Lys Phe

375 380 385act gag ctg acc ggc cgc acc cca atg atg ctg gct ggc atg acc cca 1315Thr Glu Leu Thr Gly Arg Thr Pro Met Met Leu Ala Gly Met Thr Pro390 395 400 405acc acc gtt gac cct gcc att gtt gca gcc gct gca aac ggt gga cac 1363Thr Thr Val Asp Pro Ala Ile Val Ala Ala Ala Ala Asn Gly Gly His

410 415 420tgg gct gag ctc gct ggt ggc gga cag gtt acc cca gag ctg ctg gaa 1411Trp Ala Glu Leu Ala Gly Gly Gly Gln Val Thr Pro Glu Leu Leu Glu

425 430 435acc cac atc gca cag ctc acc gac atg ctt gag cca ggt atc aac gcc 1459Thr His Ile Ala Gln Leu Thr Asp Met Leu Glu Pro Gly Ile Asn Ala

440 445 450cag ttc aac tcc atg ttc ttg gat cca tac ctg tgg aag atg cag att 1507Gln Phe Asn Ser Met Phe Leu Asp Pro Tyr Leu Trp Lys Met Gln Ile

455 460 465ggt ggc aag cgc ctt gtt cct aag gcc cgc gct aat ggt gca tcc atc 1555Gly Gly Lys Arg Leu Val Pro Lys Ala Arg Ala Asn Gly Ala Ser Ile470 475 480 485gac ggc atc gtc atc acc gcc ggc att cct gaa aag gat gaa gct gtt 1603Asp Gly Ile Val Ile Thr Ala Gly Ile Pro Glu Lys Asp Glu Ala Val

490 495 500gca ttg gtc aag gaa ctg atg cgt gat ggt ttc cct tgg atc gca ttc 1651Ala Leu Val Lys Glu Leu Met Arg Asp Gly Phe Pro Trp Ile Ala Phe

505 510 515aag cca ggt gcc atc aag cag gtt aac tct gtg ttg gct atc gct aag 1699Lys Pro Gly Ala Ile Lys Gln Val Asn Ser Val Leu Ala Ile Ala Lys

520 525 530gaa gtt cca gaa ctc ccc atc atc att cag att gag ggt ggc gtt gca 1747Glu Val Pro Glu Leu Pro Ile Ile Ile Gln Ile Glu Gly Gly Val Ala

535 540 545ggt gga cac cac tct tgg gaa gac ctc gat gag ctg ctg atc gcc acc 1795Gly Gly His His Ser Trp Glu Asp Leu Asp Glu Leu Leu Ile Ala Thr550 555 560 565tac ggc aag gtc cgc gca ctg gat aac gtg gtg ctg tgt gtc ggc ggt 1843Tyr Gly Lys Val Arg Ala Leu Asp Asn Val Val Leu Cys Val Gly Gly

570 575 580ggc att ggc tca cct gag cgc gct gct gat tac gtc acc ggt tcc tgg 1891Gly Ile Gly Ser Pro Glu Arg Ala Ala Asp Tyr Val Thr Gly Ser Trp

585 590 595tcc act tcc tac ggc ctg cca gct atg cct gtt gat ggc atc ttg gtg 1939Ser Thr Ser Tyr Gly Leu Pro Ala Met Pro Val Asp Gly Ile Leu Val

600 605 610ggt acc gct gcg atg gca acc aag gaa gca acc acc tcc cag gcc gtc 1987Gly Thr Ala Ala Met Ala Thr Lys Glu Ala Thr Thr Ser Gln Ala Val

615 620 625aag gaa ctt ctt gtt tcc acc cag ggc tct gat gaa tgg gtt cct gct 2035Lys Glu Leu Leu Val Ser Thr Gln Gly Ser Asp Glu Trp Val Pro Ala630 635 640 645ggt ggc gca aag aac gga atg gca tat ggc cgt tcc cag ctt ggc gca 2083Gly Gly Ala Lys Asn Gly Met Ala Tyr Gly Arg Ser Gln Leu Gly Ala

650 655 660gac atc cac gag atc gac aac tcc ttt gct aag gct gga cgc ctt ctt 2131Asp Ile His Glu Ile Asp Asn Ser Phe Ala Lys Ala Gly Arg Leu Leu

665 670 675gat gag gtt gca ggc cat gaa acg gat ttg caa gcg cgc ccg gat gag 2179Asp Glu Val Ala Gly His Glu Thr Asp Leu Gln Ala Arg Pro Asp Glu

680 685 690atc att 2185Ile Ile

695<210>52<211>695<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>52Val Thr Glu Leu Ser Arg Asn Phe Gly Ala Ser Arg Leu Ile Asn Arg 151015 Phe Gly Gln Glu Pro Phe Ala Phe Ala Phe Ala Gly Gln Gly Tyr Asp

20 25 30Trp Leu Lys Thr Leu Arg Ala Ala Val Ala Ala Gly Ala Gly Thr Asn

35 40 45Val Ser Asp Ile Val Glu Arg Ala Asn Ala Leu Leu Ala Leu Val Ala

50 55 60Asp Asp Leu Ile Gly Thr Leu Pro Phe Gly Phe Asp Pro Val Ala Trp 65 70 75 80Ala Asn Asn Ser Glu Asp Pro Ala Phe Asp Thr Ala Gln Ser Ala Val

85 90 95Ser Val Pro Gly Ile Phe Val Ser Gln Ile Ala Thr Leu Asp Ser Leu

100 105 110Glu Ala Gln Arg Leu Asp Val Asp Gln Ala Val Ser Ser Ile Gly His

115 120 125Ser Gln Gly Val Leu Gly Val His Leu Leu Asn Asp Ala Thr Arg Ala

130 135 140Asp Glu Leu Val Ala Ile Ala Gln Leu Ile Gly Ala Ala Ile Thr Arg145 150 155 160Thr Ala Arg Met Thr Gly Leu Ile Ala Gln Gly Asp Asn Met Pro Met

165170 175Leu Ser Ile Ala Gly Ile Ser Arg Glu Gln Leu Gln Gln Ala Ile Asp

180 185 190Ala Ala Cys Ala Glu Val Pro Ala Glu Ile Arg Pro Val Ile Gly Leu

195 200 205Arg Asn Ser Arg Asp Ser Tyr Val Leu Val Gly Arg Pro Asp Asp Asn

210 215 220Ala Arg Val Val Lys Val Ile Glu Ala Met Ala Ala Lys Asp Lys Lys225 230 235 240Ala Ile Glu Asp Lys Leu Arg Gly Gly Ser Ala Phe Ser Pro Arg Ile

245 250 255Thr Pro Leu Lys Val Gln Ala Ala Phe His His Pro Ala Met Asn Met

260 265 270Ala Val Glu Gln Thr Val Ala Trp Ala Thr Thr Ala Gly Leu Asp Val

275 280 285Glu Leu Thr Arg Glu Ile Ala Ala Asp Val Leu Val Asn Pro Val Asp

290 295 300Trp Val Ala Arg Val Asn Glu Ala Tyr Glu Ala Gly Ala Arg Trp Phe305 310 315 320Leu Asp Val Gly Pro Asp Gly Gly Ile Val Lys Leu Thr Ala Asn Ile

325 330 335Leu Glu Gly Arg Gly Ala Asp Ser Phe Tyr Val Gly Asp Ala Ala Gly

340 345 350Gln Ala Lys Ile Phe Asp Ala Gly Met Ala Pro Glu Leu Pro Val Asp

355 360 365Tyr Gln Glu Phe Ala Pro Arg Val Glu His Val Asp Gly Thr Pro Arg

370 375 380Leu Val Thr Lys Phe Thr Glu Leu Thr Gly Arg Thr Pro Met Met Leu385 390 395 400Ala Gly MetThr Pro Thr Thr Val Asp Pro Ala Ile Val Ala Ala Ala

405 410 415Ala Asn Gly Gly His Trp Ala Glu Leu Ala Gly Gly Gly Gln Val Thr

420 425 430Pro Glu Leu Leu Glu Thr His Ile Ala Gln Leu Thr Asp Met Leu Glu

435 440 445Pro Gly Ile Asn Ala Gln Phe Asn Ser Met Phe Leu Asp Pro Tyr Leu

450 455 460Trp Lys Met Gln Ile Gly Gly Lys Arg Leu Val Pro Lys Ala Arg Ala465 470 475 480Asn Gly Ala Ser Ile Asp Gly Ile Val Ile Thr Ala Gly Ile Pro Glu

485 490 495Lys Asp Glu Ala Val Ala Leu Val Lys Glu Leu Met Arg Asp Gly Phe

500 505 510Pro Trp Ile Ala Phe Lys Pro Gly Ala Ile Lys Gln Val Asn Ser Val

515 520 525Leu Ala Ile Ala Lys Glu Val Pro Glu Leu Pro Ile Ile Ile Gln Ile

530 535 540Glu Gly Gly Val Ala Gly Gly His His Ser Trp Glu Asp Leu Asp Glu545 550 555 560Leu Leu Ile Ala Thr Tyr Gly Lys Val Arg Ala Leu Asp Asn Val Val

565 570 575Leu Cys Val Gly Gly Gly Ile Gly Ser Pro Glu Arg Ala Ala Asp Tyr

580 585 590Val Thr Gly Ser Trp Ser Thr Ser Tyr Gly Leu Pro Ala Met Pro Val

595 600 605Asp Gly Ile Leu Val Gly Thr Ala Ala get Ala Thr Lys Glu Ala Thr

610 615 620Thr SerGln Ala Val Lys Glu Leu Leu Val Ser Thr Gln Gly Ser Asp625 630 635 640Glu Trp Val Pro Ala Gly Gly Ala Lys Asn Gly Met Ala Tyr Gly Arg

645 650 655Ser Gln Leu Gly Ala Asp Ile His Glu Ile Asp Asn Ser Phe Ala Lys

660 665 670Ala Gly Arg Leu Leu Asp Glu Val Ala Gly His Glu Thr Asp Leu Gln

675 680 685Ala Arg Pro Asp Glu Ile Ile

690695<210>53<211>3831<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (3831)<223>FRXA00572<400>53cag tgg ctc aac cgc tac ctc gag ctg tct ggc cct gtt gat ggt cag 48Gln Trp Leu Asn Arg Tyr Leu Glu Leu Ser Gly Pro Val Asp Gly Gln 151015 tgg att gat gct tcc tgg gct gca cgt ttt gcc cag atg ctg gag cgt 96Trp Ile Asp Ala Ser Trp Ala Ala Arg Phe Ala Gln Met Leu Glu Arg<400>53cag tgg ctc aac cgc tac ctc gag ctg tct ggc cct gtt gat ggt cag Gln Trp Leu Asn Arg Tyr Leu Glu Leu Ser Gly Pro Val Asp Gly Gln tgg att gat gct tcc tgg gct gca cgt ttt gcc cag atg ctg gag cgt Trp Ile Asp Ala Ser Trp Ala Ala Arg Phe Ala Gln Met Leu Glu Arg

20 25 30gcc gag gcg cgt ttg atc gag cag gat cat ggc caa ttt gag cca agc 144Ala Glu Ala Arg Leu Ile Glu Gln Asp His Gly Gln Phe Glu Pro Ser

35 40 45ctg acg gtg gag gat ggc gtc gac aag ctt gtt gct gct tac ccg cat 192Leu Thr Val Glu Asp Gly Val Asp Lys Leu Val Ala Ala Tyr Pro His

50 55 60gcc gca acc gac ctg ctc acc ccg gct gat gtc gcc tgg ttc ttg ggc 240Ala Ala Thr Asp Leu Leu Thr Pro Ala Asp Val Ala Trp Phe Leu Gly 6570 75 80ctg tgc cgc acg ccg ggc aag cct gtg aac ttt gtg ccc gtc att gat 288Leu Cys Arg Thr Pro Gly Lys Pro Val Asn Phe Val Pro Val Ile Asp

85 90 95aag gac gtg cgt cgc tgg tgg cgc tcg gac tcc ctg tgg cag tcc cac 336Lys Asp Val Arg Arg Trp Trp Arg Ser Asp Ser Leu Trp Gln Ser His

100 105 110gat gat cgc tac acc gct gat cag gtg gct att atc cct ggt gtc gtc 384Asp Asp Arg Tyr Thr Ala Asp Gln Val Ala Ile Ile Pro Gly Val Val

115 120 125gcc gtt gct ggc atc acc aag gcc aac gaa cct gtc gct gac ctg ctt 432Ala Val Ala Gly Ile Thr Lys Ala Asn Glu Pro Val Ala Asp Leu Leu

130 135 140gat cgc ttt gtc gac gcc acc atc gag cgc atc gat gag cac gat tcc 480Asp Arg Phe Val Asp Ala Thr Ile Glu Arg Ile Asp Glu His Asp Ser145 150 155 160cgc tcc cgc gac atc atg ggc aaa gtg ctt tcc tca cct ggc aca ttc 528Arg Ser Arg Asp Ile Met Gly Lys Val Leu Ser Ser Pro Gly Thr Phe

165 170 175tgg gct ggc cgc aac atc cca tcg gtg atc cac agc ctt ggg cat gct 576Trp Ala Gly Arg Asn Ile Pro Ser Val Ile His Ser Leu Gly His Ala

180 185 190gac aag tgg tcc cgc tcc gaa ttc gaa gca ttc cat agc cca acc ggc 624Asp Lys Trp Ser Arg Ser Glu Phe Glu Ala Phe His Ser Pro Thr Gly

195 200 205gcc aac ttg gtg tac gaa gac gcc gag cac gcg atg ctg act gtg cct 672Ala Asn Leu Val Tyr Glu Asp Ala Glu His Ala Met Leu Thr Val Pro

210 215 220ttg gcg ggt tcc acc gca ttc ggc acc acc gct gag ctg aaa atccgt 720Leu Ala Gly Ser Thr Ala Phe Gly Thr Thr Ala Glu Leu Lys Ile Arg225 230 235 240ttc acc agc ccc atc gac gct ctg cca agc gct gtc cca ctg gtc acc 768Phe Thr Ser Pro Ile Asp Ala Leu Pro Ser Ala Val Pro Leu Val Thr

245 250 255cag gaa gac gct gaa gcc gcg atg ggt gaa ctg acc cgc atc gca gct 816Gln Glu Asp Ala Glu Ala Ala Met Gly Glu Leu Thr Arg Ile Ala Ala

260 265 270ggc ggc acc ctg gca act gtg aac aat ggc acc gct acc tgg gaa acc 864Gly Gly Thr Leu Ala Thr Val Asn Asn Gly Thr Ala Thr Trp Glu Thr

275 280 285tcc gtc gat gcc ggc gtc atc gct gac tac aac aac gtc acc gca ggc 912Ser Val Asp Ala Gly Val Ile Ala Asp Tyr Asn Asn Val Thr Ala Gly

290 295 300tac ctg cca gca tcc gtt gtt cct gca cac acc gca cct gac gtg ctg 960Tyr Leu Pro Ala Ser Val Val Pro Ala His Thr Ala Pro Asp Val Leu305 310 315 320gtt ggc cgc gca tgg cca gca gtt ttc gct gcc gta aag tcc gca gtc 1008Val Gly Arg Ala Trp Pro Ala Val Phe Ala Ala Val Lys Ser Ala Val

325 330 335atc cca ggc acc gat tcc gca tcc gtt gtg gaa ggc atg ctg tcc ctg 1056Ile Pro Gly Thr Asp Ser Ala Ser Val Val Glu Gly Met Leu Ser Leu

340 345 350gtt cac ctg gag cac cac att gtg ctc aag tcc gat gtc cca acc gac 1104Val His Leu Glu His His Ile Val Leu Lys Ser Asp Val Pro Thr Asp

355 360 365ggc gcg ctg aag gtt tcc gcg act gcc gat gag gta gtc gat acc gac 1152Gly Ala Leu Lys Val Ser Ala Thr Ala Asp Glu Val Val Asp Thr Asp

370 375 380ctg ggt cgc ctc gtg atc gtg cgc gca gaa atc gcc gac gca gaa ggc 1200Leu Gly Arg Leu Val Ile Val Arg Ala Glu Ile Ala Asp Ala Glu Gly385 390 395 400aac ctg att gct acg ttg gct gag cgt ttc gcg atc cgc gga cgc aag 1248Asn Leu Ile Ala Thr Leu Ala Glu Arg Phe Ala Ile Arg Gly Arg Lys

405 410 415ggc aac gct gtc gca cgc acc aac acc tcc gca ctg cca acc acc gtg 1296Gly Asn Ala Val Ala Arg Thr Asn Thr Ser Ala Leu Pro Thr Thr Val

420 425 430gac acc cca cgc tca gct cgc gca gtg gca acc gtt gtt gca cct gaa 1344Asp Thr Pro Arg Ser Ala Arg Ala Val Ala Thr Val Val Ala Pro Glu

435 440 445tcc atg cgc cca ttc gct gtg atc tcc ggt gac cgc aac cca att cac 1392Ser Met Arg Pro Phe Ala Val Ile Ser Gly Asp Arg Asn Pro Ile His

450 455 460gtc tct gat gtt gcg gct tcc ctg gct ggt ctg cca ggt gtg atc gtg 1440Val Ser Asp Val Ala Ala Ser Leu Ala Gly Leu Pro Gly Val Ile Val465 470 475 480cac ggc atg tgg acc tct gcc atc ggt gaa ctg atc gcc ggt gca gca 1488His Gly Met Trp Thr Ser Ala Ile Gly Glu Leu Ile Ala Gly Ala Ala

485 490 495ttc aac gat gag cag atc caa act ccc gca gcc aag gtc gtg gaa tac 1536Phe Asn Asp Glu Gln Ile Gln Thr Pro Ala Ala Lys Val Val Glu Tyr

500 505 510acc gca acc atg ctg gca cca gtt ctt cca ggt gaa gaa att gag ttc 1584Thr Ala Thr Met Leu Ala Pro Val Leu Pro Gly Glu Glu Ile Glu Phe

515 520 525agc gtt gag cgc tcc gca gtg gac aac cgc ccagga atg gga gag gtc 1632Ser Val Glu Arg Ser Ala Val Asp Asn Arg Pro Gly Met Gly Glu Val

530 535 540cgc acc gtt acc gca acc gtc aac ggc aac tta gtg ctt acc gcc acc 1680Arg Thr Val Thr Ala Thr Val Asn Gly Asn Leu Val Leu Thr Ala Thr545 550 555 560gct gtt gtg gca gct cca tct act ttc tac gca ttc cca ggc cag ggc 1728Ala Val Val Ala Ala Pro Ser Thr Phe Tyr Ala Phe Pro Gly Gln Gly

565 570 575att cag tcc cag ggc atg ggt atg gaa gca cgc cgt aac tct cag gca 1776Ile Gln Ser Gln Gly Met Gly Met Glu Ala Arg Arg Asn Ser Gln Ala

580 585 590gct cgc gct atc tgg gac cgc gcc gat gca cac acc cgc aat aag ctg 1824Ala Arg Ala Ile Trp Asp Arg Ala Asp Ala His Thr Arg Asn Lys Leu

595 600 605ggc ttc tcc atc gtg gaa atc gtg gaa aac aac cca cgc gaa gta acc 1872Gly Phe Ser Ile Val Glu Ile Val Glu Asn Asn Pro Arg Glu Val Thr

610 615 620gtg gca ggg gag aag ttc ttc cac cca gac ggc gtt ttg tac ctc acc 1920Val Ala Gly Glu Lys Phe Phe His Pro Asp Gly Val Leu Tyr Leu Thr625 630 635 640cag ttc acc cag gtg ggc atg gca act ctg ggc gtt gct cag atc gct 1968Gln Phe Thr Gln Val Gly Met Ala Thr Leu Gly Val Ala Gln Ile Ala

645 650 655gaa atg cgt gaa gca cat gcc ttg aac cag cgt gca tac ttt gct gga 2016Glu Met Arg Glu Ala His Ala Leu Asn Gln Arg Ala Tyr Phe Ala Gly

660 665 670cac tcc gtt ggt gag tac aac gcg ctt gct gca tat gct ggt gtg ctg 2064His Ser Val Gly Glu Tyr Asn Ala Leu Ala Ala Tyr Ala Gly Val Leu

675 680 685tcc ctg gaa tcc gtt ctg gag atc gtt tac cgt cgt ggc ttg acc atg 2112Ser Leu Glu Ser Val Leu Glu Ile Val Tyr Arg Arg Gly Leu Thr Met

690 695 700cac cgc ttg gtg gat cgc gat gaa aac ggt ctg tcc aac tac gcg ctc 2160His Arg Leu Val Asp Arg Asp Glu Asn Gly Leu Ser Asn Tyr Ala Leu705 710 715 720gca gct ctt cgc ccc aac aag atg ggt ctg acc gca gac aac gtt ttc 2208Ala Ala Leu Arg Pro Asn Lys Met Gly Leu Thr Ala Asp Asn Val Phe

725 730 735gat tac gtt gcg tct gtt tcc gaa gct tcc ggt gaa ttc ctg gag atc 2256Asp Tyr Val Ala Ser Val Ser Glu Ala Ser Gly Glu Phe Leu Glu Ile

740 745 750gtt aac tac aac ttg gct ggc ctg cag tac gca gtt gct gga acc cag 2304Val Asn Tyr Asn Leu Ala Gly Leu Gln Tyr Ala Val Ala Gly Thr Gln

755 760 765gct ggt ctt gcc gcc ctt cgt gcc gat gtt gag aac cgt gca cca ggt 2352Ala Gly Leu Ala Ala Leu Arg Ala Asp Val Glu Asn Arg Ala Pro Gly

770 775 780cag cgt gcc ttc att ttg atc cct ggc att gac gtg cca ttc cac tcc 2400Gln Arg Ala Phe Ile Leu Ile Pro Gly Ile Asp Val Pro Phe His Ser785 790 795 800tcc aag ctg cgc gac ggt gtg ggc gcg ttc cgt gag cac ctt gat tcc 2448Ser Lys Leu Arg Asp Gly Val Gly Ala Phe Arg Glu His Leu Asp Ser

805 810 815ctg atc cca gct gag ctg gat ctg gat gtg ctg gtt ggc cgc tac att 2496Leu Ile Pro Ala Glu Leu Asp Leu Asp Val Leu Val Gly Arg Tyr Ile

820 825 830cca aac ttg gtg gct cgc cca ttc gaa ctc act gaa gag ttc gtg gca 2544Pro Asn Leu Val Ala Arg Pro Phe Glu Leu Thr Glu Glu Phe Val Ala

835 840 845tcc atg gca gaa gtg gtg gag tcc acc tat gtc aat gag atc ttg gct 2592Ser Met Ala Glu Val Val Glu Ser Thr Tyr Val Asn Glu Ile Leu Ala

850 855 860gat ttc aag gct gct tcc gcc gat aag cag aag ctt gcc cgc acg ttg 2640Asp Phe Lys Ala Ala Ser Ala Asp Lys Gln Lys Leu Ala Arg Thr Leu865 870 875 880ctt att gag ctg ctt gca tgg cag ttc gca tca cct gtg cgc tgg atc 2688Leu Ile Glu Leu Leu Ala Trp Gln Phe Ala Ser Pro Val Arg Trp Ile

885 890 895gag act cag gat ctg ttg atc aag ggc ctt caa gct gag cgt ttc gtg 2736Glu Thr Gln Asp Leu Leu Ile Lys Gly Leu Gln Ala Glu Arg Phe Val

900 905 910gag gtc ggt gtt ggc tct gct cca acg ctt gcc aac atg atg ggc cag 2784Glu Val Gly Val Gly Ser Ala Pro Thr Leu Ala Asn Met Met Gly Gln

915 920 925acc ctg cgc ctt cct cag tac gcg gac gcc acc att gag gtg tta aac 2832Thr Leu Arg Leu Pro Gln Tyr Ala Asp Ala Thr Ile Glu Val Leu Asn

930 935 940att gag cgc gat cgc cca gtt gtg ttc gct acc gat gag gtt gtg cgt 2880Ile Glu Arg Asp Arg Pro Val Val Phe Ala Thr Asp Glu Val Val Arg945 950 955 960gaa gtg gcg gtt gaa gag acc cca gca gct cct gca gaa acc act gaa 2928Glu Val Ala Val Glu Glu Thr Pro Ala Ala Pro Ala Glu Thr Thr Glu

965 970 975acc cca gca acc cca gca acc cca gcc cct gtt gca gct gca gcc cct 2976Thr Pro Ala Thr Pro Ala Thr Pro Ala Pro Val Ala Ala Ala Ala Pro

980 985 990gcc acc ggc ggc cct cgc cca gat gac atc agc ttc act cct tct gat 3024Ala Thr Gly Gly Pro Arg Pro Asp Asp Ile Ser Phe Thr Pro Ser Asp

995 1000 1005gcc act gaa atg ctc atc gct atc tgg acc aag gtt cgc cca gat cag 3072Ala Thr Glu Met Leu Ile Ala Ile Trp Thr Lys Val Arg Pro Asp Gln

1010 1015 1020atg ggt gcc act gat tcc atc gag acc ctg gtt gag ggc gtg tcc tct 3120Met Gly Ala Thr Asp Ser Ile Glu Thr Leu Val Glu Gly Val Ser Ser1025 1030 1035 1040cgc cgt aac cag ctc ctg ctg gat ctt ggt gtg gag ttc ggc ctc ggc 3168Arg Arg Asn Gln Leu Leu Leu Asp Leu Gly Val Glu Phe Gly Leu Gly

1045 1050 1055gca att gac gga gca gcc gat gct gag ctc ggt gat cta aag gtc acc 3216Ala Ile Asp Gly Ala Ala Asp Ala Glu Leu Gly Asp Leu Lys Val Thr

1060 1065 1070gtg tcc aag atg gct aag ggc tac aag gcg ttt ggc cct gtg ctc tcc 3264Val Ser Lys Met Ala Lys Gly Tyr Lys Ala Phe Gly Pro Val Leu Ser

1075 1080 1085gat gct gca gct gat gcc ctg cgt cgc ctc act ggt cct acc ggt aag 3312Asp Ala Ala Ala Asp Ala Leu Arg Arg Leu Thr Gly Pro Thr Gly Lys

1090 1095 1100cgc ccg gga tac atc gca gag cgc gtc acc ggc acg tgg gaa ttg ggc 3360Arg Pro Gly Tyr Ile Ala Glu Arg Val Thr Gly Thr Trp Glu Leu Gly1105 1110 1115 1120cag ggc tgg gct gac cac gtg gtc gct gaa gtt gtg atc ggc gcc cgc 3408Gln Gly Trp Ala Asp His Val Val Ala Glu Val Val Ile Gly Ala Arg

1125 1130 1135gaa ggc gca tcc ctg cgc ggc ggc gac ctg gcg tca ctg tct cct gca 3456Glu Gly Ala Ser Leu Arg Gly Gly Asp Leu Ala Ser Leu Ser Pro Ala

1140 1145 1150agc cca gcg tct gca tca gat ctt gat tcg ctt atc gac gca gcc gtc 3504Ser Pro Ala Ser Ala Ser Asp Leu Asp Ser Leu Ile Asp Ala Ala Val

1155 1160 1165cag gcc gta gcc tcc cgc cgc ggc gtt gcg gtc tcc ctg cct tca gca 3552Gln Ala Val Ala Ser Arg Arg Gly Val Ala Val Ser Leu Pro Ser Ala

1170 1175 1180ggc ggc gct gcc ggt ggc gtg gtt gat tcc gca gct ctt ggc gag ttt 3600Gly Gly Ala Ala Gly Gly Val Val Asp Ser Ala Ala Leu Gly Glu Phe1185 1190 1195 1200gca gag cag gtc acc gga cac gat ggt gtg ctt gct cag gca gcc cgc 3648Ala Glu Gln Val Thr Gly His Asp Gly Val Leu Ala Gln Ala Ala Arg

1205 1210 1215acc atc ttg acc cag ttg ggt ctt gat aag cca gca acc gtt tcc gtg 3696Thr Ile Leu Thr Gln Leu Gly Leu Asp Lys Pro Ala Thr Val Ser Val

1220 1225 1230gaa gac acc gca gag gaa gac ctc tac gag ttg gtc tcc aag gaa ctc 3744Glu Asp Thr Ala Glu Glu Asp Leu Tyr Glu Leu Val Ser Lys Glu Leu

1235 1240 1245ggt tct gat tgg cca cgt cag gtt gca cca agc ttc gat gaa gaa aag 3792Gly Ser Asp Trp Pro Arg Gln Val Ala Pro Ser Phe Asp Glu Glu Lys

125012551260 gtt gtt ctg ctt gat gac cgt tgg gct tct gcg cgt gag 3831Val Val Leu Leu Asp Asp Arg Trp Ala Ser Ala Arg Glu 126512701275<210>54<211>1277<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>54Gln Trp Leu Asn Arg Tyr Leu Glu Leu Ser Gly Pro Val Asp Gly Gln 151015 Trp Ile Asp Ala Ser Trp Ala Ala Arg Phe Ala Gln Met Leu Glu Arg

20 25 30Ala Glu Ala Arg Leu Ile Glu Gln Asp His Gly Gln Phe Glu Pro Ser

35 40 45Leu Thr Val Glu Asp Gly Val Asp Lys Leu Val Ala Ala Tyr Pro His

50 55 60Ala Ala Thr Asp Leu Leu Thr Pro Ala Asp Val Ala Trp Phe Leu Gly 65 70 75 80Leu Cys Arg Thr Pro Gly Lys Pro Val Asn Phe Val Pro Val Ile Asp

85 90 95Lys Asp Val Arg Arg Trp Trp Arg Ser Asp Ser Leu Trp Gln Ser His

100 105 110Asp Asp Arg Tyr Thr Ala Asp Gln Val Ala Ile Ile Pro Gly Val Val

115 120 125Ala Val Ala Gly Ile Thr Lys Ala Asn Glu Pro Val Ala Asp Leu Leu

130 135 140Asp Arg Phe Val Asp Ala Thr Ile Glu Arg Ile Asp Glu His Asp Ser145 150 155 160Arg Ser Arg Asp Ile Met Gly Lys Val Leu Ser Ser Pro Gly Thr Phe

165 170 175Trp Ala Gly Arg Asn Ile Pro Ser Val Ile His Ser Leu Gly His Ala

180 185 190Asp Lys Trp Ser Arg Ser Glu Phe Glu Ala Phe His Ser Pro Thr Gly

195 200 205Ala Asn Leu Val Tyr Glu Asp Ala Glu His Ala Met Leu Thr Val Pro

210 215 220Leu Ala Gly Ser Thr Ala Phe Gly Thr Thr Ala Glu Leu Lys Ile Arg225 230 235 240Phe Thr Ser Pro Ile Asp Ala Leu Pro Ser Ala Val Pro Leu Val Thr

245 250 255Gln Glu Asp Ala Glu Ala Ala Met Gly Glu Leu Thr Arg Ile Ala Ala

260 265 270Gly Gly Thr Leu Ala Thr Val Asn Asn Gly Thr Ala Thr Trp Glu Thr

275 280 285Ser Val Asp Ala Gly Val Ile Ala Asp Tyr Asn Asn Val Thr Ala Gly

290 295 300Tyr Leu Pro Ala Ser Val Val Pro Ala His Thr Ala Pro Asp Val Leu305 310 315 320Val Gly Arg Ala Trp Pro Ala Val Phe Ala Ala Val Lys Ser Ala Val

325 330 335Ile Pro Gly Thr Asp Ser Ala Ser Val Val Glu Gly Met Leu Ser Leu

340 345 350Val His Leu Glu His His Ile Val Leu Lys Ser Asp Val Pro Thr Asp

355 360 365Gly Ala Leu Lys Val Ser Ala Thr Ala Asp Glu Val Val Asp Thr Asp

370 375 380Leu Gly Arg Leu Val Ile Val Arg Ala Glu Ile Ala Asp Ala Glu Gly385 390 395 400Asn Leu Ile Ala Thr Leu Ala Glu Arg Phe Ala Ile Arg Gly Arg Lys

405 410 415Gly Asn Ala Val Ala Arg Thr Asn Thr Ser Ala Leu Pro Thr Thr Val

420 425 430Asp Thr Pro Arg Ser Ala Arg Ala Val Ala Thr Val Val Ala Pro Glu

435 440 445Ser Met Arg Pro Phe Ala Val Ile Ser Gly Asp Arg Asn Pro Ile His

450 455 460Val Ser Asp Val Ala Ala Ser Leu Ala Gly Leu Pro Gly Val Ile Val465470 475 480His Gly Met Trp Thr Ser Ala Ile Gly Glu Leu Ile Ala Gly Ala Ala

485 490 495Phe Asn Asp Glu Gln Ile Gln Thr Pro Ala Ala Lys Val Val Glu Tyr

500 505 510Thr Ala Thr Met Leu Ala Pro Val Leu Pro Gly Glu Glu Ile Glu Phe

515 520 525Ser Val Glu Arg Ser Ala Val Asp Asn Arg Pro Gly Met Gly Glu Val

530 535 540Arg Thr Val Thr Ala Thr Val Asn Gly Asn Leu Val Leu Thr Ala Thr545 550 555 560Ala Val Val Ala Ala Pro Ser Thr Phe Tyr Ala Phe Pro Gly Gln Gly

565 570 575Ile Gln Ser Gln Gly Met Gly Met Glu Ala Arg Arg Asn Ser Gln Ala

580 585 590Ala Arg Ala Ile Trp Asp Arg Ala Asp Ala His Thr Arg Asn Lys Leu

595 600 605Gly Phe Ser Ile Val Glu Ile Val Glu Asn Asn Pro Arg Glu Val Thr

610 615 620Val Ala Gly Glu Lys Phe Phe His Pro Asp Gly Val Leu Tyr Leu Thr625 630 635 640Gln Phe Thr Gln Val Gly Met Ala Thr Leu Gly Val Ala Gln Ile Ala

645 650 655Glu Met Arg Glu Ala His Ala Leu Asn Gln Arg Ala Tyr Phe Ala Gly

660 665 670His Ser Val Gly Glu Tyr Asn Ala Leu Ala Ala Tyr Ala Gly Val Leu

675 680 685Ser Leu Glu Ser Val Leu Glu Ile Val Tyr Arg Arg Gly Leu Thr Met

690695 700His Arg Leu Val Asp Arg Asp Glu Asn Gly Leu Ser Asn Tyr Ala Leu705 710 715 720Ala Ala Leu Arg Pro Asn Lys Met Gly Leu Thr Ala Asp Asn Val Phe

725 730 735Asp Tyr Val Ala Ser Val Ser Glu Ala Ser Gly Glu Phe Leu Glu Ile

740 745 750Val Asn Tyr Asn Leu Ala Gly Leu Gln Tyr Ala Val Ala Gly Thr Gln

755 760 765Ala Gly Leu Ala Ala Leu Arg Ala Asp Val Glu Asn Arg Ala Pro Gly

770 775 780Gln Arg Ala Phe Ile Leu Ile Pro Gly Ile Asp Val Pro Phe His Ser785 790 795 800Ser Lys Leu Arg Asp Gly Val Gly Ala Phe Arg Glu His Leu Asp Ser

805 810 815Leu Ile Pro Ala Glu Leu Asp Leu Asp Val Leu Val Gly Arg Tyr Ile

820 825 830Pro Asn Leu Val Ala Arg Pro Phe Glu Leu Thr Glu Glu Phe Val Ala

835 840 845Ser Met Ala Glu Val Val Glu Ser Thr Tyr Val Asn Glu Ile Leu Ala

850 855 860Asp Phe Lys Ala Ala Ser Ala Asp Lys Gln Lys Leu Ala Arg Thr Leu865 870 875 880Leu Ile Glu Leu Leu Ala Trp Gln Phe Ala Ser Pro Val Arg Trp Ile

885 890 895Glu Thr Gln Asp Leu Leu Ile Lys Gly Leu Gln Ala Glu Arg Phe Val

900 905 910Glu Val Gly Val Gly Ser Ala Pro Thr Leu Ala Asn Met Met Gly Gln

915 920 925Thr Leu Arg Leu Pro Gln Tyr Ala Asp Ala Thr Ile Glu Val Leu Asn

930 935 940Ile Glu Arg Asp Arg Pro Val Val Phe Ala Thr Asp Glu Val Val Arg945 950 955 960Glu Val Ala Val Glu Glu Thr Pro Ala Ala Pro Ala Glu Thr Thr Glu

965 970 975Thr Pro Ala Thr Pro Ala Thr Pro Ala Pro Val Ala Ala Ala Ala Pro

980 985 990Ala Thr Gly Gly Pro Arg Pro Asp Asp Ile Ser Phe Thr Pro Ser Asp

995 1000 1005Ala Thr Glu Met Leu Ile Ala Ile Trp Thr Lys Val Arg Pro Asp Gln

1010 1015 1020Met Gly Ala Thr Asp Ser Ile Glu Thr Leu Val Glu Gly Val Ser Ser1025 1030 1035 1040Arg Arg Asn Gln Leu Leu Leu Asp Leu Gly Val Glu Phe Gly Leu Gly

1045 1050 1055Ala Ile Asp Gly Ala Ala Asp Ala Glu Leu Gly Asp Leu Lys Val Thr

1060 1065 1070Val Ser Lys Met Ala Lys Gly Tyr Lys Ala Phe Gly Pro Val Leu Ser

1075 1080 1085Asp Ala Ala Ala Asp Ala Leu Arg Arg Leu Thr Gly Pro Thr Gly Lys

1090 1095 1100Arg Pro Gly Tyr Ile Ala Glu Arg Val Thr Gly Thr Trp Glu Leu Gly1105 1110 1115 1120Gln Gly Trp Ala Asp His Val Val Ala Glu Val Val Ile Gly Ala Arg

1125 1130 1135Glu Gly Ala Ser Leu Arg Gly Gly Asp Leu Ala Ser Leu Ser Pro Ala

11401145 1150Ser Pro Ala Ser Ala Ser Asp Leu Asp Ser Leu Ile Asp Ala Ala Val

1155 1160 1165Gln Ala Val Ala Ser Arg Arg Gly Val Ala Val Ser Leu Pro Ser Ala

1170 1175 1180Gly Gly Ala Ala Gly Gly Val Val Asp Ser Ala Ala Leu Gly Glu Phe1185 1190 1195 1200Ala Glu Gln Val Thr Gly His Asp Gly Val Leu Ala Gln Ala Ala Arg

1205 1210 1215Thr Ile Leu Thr Gln Leu Gly Leu Asp Lys Pro Ala Thr Val Ser Val

1220 1225 1230Glu Asp Thr Ala Glu Glu Asp Leu Tyr Glu Leu Val Ser Lys Glu Leu

1235 1240 1245Gly Ser Asp Trp Pro Arg Gln Val Ala Pro Ser Phe Asp Glu Glu Lys

125012551260 Val Val Leu Leu Asp Asp Arg Trp Ala Ser Ala Arg Glu 126512701275<210>55<211>4953<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (4930)<223>RXA02582<400>55tggatgtcta ttctcctcag cctcgttttg gttgaggcgg atagttttaa tattttttta 60agtttaagtt gtaatcgagc tgaaaggctg aggcctcaat atg gaa cag agc caa 115

Met Glu Gln Ser Gln

1 5tcg tcg gat cag aag atg acc gtt gaa cag gtt cgc acc tgg ctc cgt 163Ser Ser Asp Gln Lys Met Thr Val Glu Gln Val Arg Thr Trp Leu Arg

10 15 20gat tgg gtt gtc cgc acc acg ggt att ccg gtg gag gaa gtt acg gat 211Asp Trp Val Val Arg Thr Thr Gly Ile Pro Val Glu Glu Val Thr Asp

2530 35gac aag gca atg gag acc ttt ggc ctt tcc tct cgc gat gtt gtt gtg 259Asp Lys Ala Met Glu Thr Phe Gly Leu Ser Ser Arg Asp Val Val Val

40 45 50ttg tct ggt gag ctg gaa aac ctg ctg gac acc tcc ttg gat gcc acc 307Leu Ser Gly Glu Leu Glu Asn Leu Leu Asp Thr Ser Leu Asp Ala Thr

55 60 65atc gct tat gag tac cca acg atc cgt agt ttg gcg cag cgc ctt gtt 355Ile Ala Tyr Glu Tyr Pro Thr Ile Arg Ser Leu Ala Gln Arg Leu Val 70 75 80 85gag ggc gag cct cgt cgt gca cat acc cag cgt gaa ttg aat ttc tcc 403Glu Gly Glu Pro Arg Arg Ala His Thr Gln Arg Glu Leu Asn Phe Ser

90 95 100gcg gtg agc gat tcc cca ggt tcc cac gat att gcg gtt gtc ggt atg 451Ala Val Ser Asp Ser Pro Gly Ser His Asp Ile Ala Val Val Gly Met

105 110 115gct gcg cgt tac cca ggc gct gag agc ctg gag gat atg tgg aag cta 499Ala Ala Arg Tyr Pro Gly Ala Glu Ser Leu Glu Asp Met Trp Lys Leu

120 125 130ctc gtc gag ggc cgt gac ggt atc tcg gat cta ccg att ggc cgt tgg 547Leu Val Glu Gly Arg Asp Gly Ile Ser Asp Leu Pro Ile Gly Arg Trp

135 140 145tct gag tat gca ggc gat gag gtt atg tct cgg aag atg gaa gag ttt 595Ser Glu Tyr Ala Gly Asp Glu Val Met Ser Arg Lys Met Glu Glu Phe150 155 160 165tct acc atc ggt ggc tac ctg tca gat atc tct agc ttt gat gcg gag 643Ser Thr Ile Gly Gly Tyr Leu Ser Asp Ile Ser Ser Phe Asp Ala Glu

170 175 180ttc ttt ggt ctg tct ccg ctc gag gcc gcc aac atg gat cct cag cag 691Phe Phe Gly Leu Ser Pro Leu Glu Ala Ala Asn MetAsp Pro Gln Gln

185 190 195cgt att ttg ctg gag cta acg tgg gag gct ttg gag tac gct cgc atc 739Arg Ile Leu Leu Glu Leu Thr Trp Glu Ala Leu Glu Tyr Ala Arg Ile

200 205 210gca cca aac act ttg cgt ggc gaa gcc gtg ggc gtg ttc ata ggt tcc 787Ala Pro Asn Thr Leu Arg Gly Glu Ala Val Gly Val Phe Ile Gly Ser

215 220 225tcc aac aac gat tac ggc atg atg atc gct gcc gat cca gca gaa gca 835Ser Asn Asn Asp Tyr Gly Met Met Ile Ala Ala Asp Pro Ala Glu Ala230 235 240 245cat cct tat gcg ctg act ggt act tct agt gcg att gtc gct aac cgc 883His Pro Tyr Ala Leu Thr Gly Thr Ser Ser Ala Ile Val Ala Asn Arg

250 255 260att aac tac gct ttc gat ttc cgc ggt cct tcc gtc aac gtg gat acc 931Ile Asn Tyr Ala Phe Asp Phe Arg Gly Pro Ser Val Asn Val Asp Thr

265 270 275gca tgt tct tct tct ctg gta gcg gtt cac cag gct gtc cgt gcg ctg 979Ala Cys Ser Ser Ser Leu Val Ala Val His Gln Ala Val Arg Ala Leu

280 285 290cgt aat ggc gaa gcg gat cac gct atc gct ggt gga gtg aac att ttg 1027Arg Asn Gly Glu Ala Asp His Ala Ile Ala Gly Gly Val Asn Ile Leu

295 300 305gca tct cca ttt gtc aca act gca ttc gct gag ctc ggt gtg atc agc 1075Ala Ser Pro Phe Val Thr Thr Ala Phe Ala Glu Leu Gly Val Ile Ser310 315 320 325cca acc ggc aag atc cac gca ttc tct gat gat gcc gat ggt ttc gtg 1123Pro Thr Gly Lys Ile His Ala Phe Ser Asp Asp Ala Asp Gly Phe Val

330 335 340cgt tcc gac ggc gcc gga gtc gtt gtg ctg aag cgc gtg gat gac gca 1171Arg Ser Asp Gly Ala Gly Val Val Val Leu Lys Arg Val Asp Asp Ala

345 350 355atc cgc gac ggc gac aag atc atc ggt gtg atc aag ggt tct gca gtg 1219Ile Arg Asp Gly Asp Lys Ile Ile Gly Val Ile Lys Gly Ser Ala Val

360 365 370aac tcc gat ggt cac tcc aac gga ctg acc gct cca aac cct gac gca 1267Asn Ser Asp Gly His Ser Asn Gly Leu Thr Ala Pro Asn Pro Asp Ala

375 380 385cag gtt gat gtg ctg cag cgt gca tat gtt gac gct cag gtt gat ccc 1315Gln Val Asp Val Leu Gln Arg Ala Tyr Val Asp Ala Gln Val Asp Pro390 395 400 405acc acc gtg gat tac gtt gag gct cac ggc acc ggc acc atc ctg ggt 1363Thr Thr Val Asp Tyr Val Glu Ala His Gly Thr Gly Thr Ile Leu Gly

410 415 420gac ccc att gaa gca act gcc ctg ggt gct gtt ttg ggc tat ggc cgt 1411Asp Pro Ile Glu Ala Thr Ala Leu Gly Ala Val Leu Gly Tyr Gly Arg

425 430 435gac gca tcc acc cca act ctt ctg ggc tct gca aag tcc aac ttc ggc 1459Asp Ala Ser Thr Pro Thr Leu Leu Gly Ser Ala Lys Ser Asn Phe Gly

440 445 450cac act gag tca gct gcg ggt att gca ggt gtc atc aag gtg ctg ctt 1507His Thr Glu Ser Ala Ala Gly Ile Ala Gly Val Ile Lys Val Leu Leu

455 460 465gct ttg cag aac aag act ctg cca cca acc gtg aac ttt gca ggt cca 1555Ala Leu Gln Asn Lys Thr Leu Pro Pro Thr Val Asn Phe Ala Gly Pro470 475 480 485aac cgc tac atc gat ttc gat gct gag cgt ttg gaa gtt gtg gaa gat 1603Asn Arg Tyr Ile Asp Phe Asp Ala GluArg Leu Glu Val Val Glu Asp

490 495 500cca cgt gaa tgg ccg gaa tac aac ggt cac gca gta gct ggt gtg tct 1651Pro Arg Glu Trp Pro Glu Tyr Asn Gly His Ala Val Ala Gly Val Ser

505 510 515gcg ttc ggg ttc ggt gga acc aac gcg cac gtg gtg atc tct gag tac 1699Ala Phe Gly Phe Gly Gly Thr Asn Ala His Val Val Ile Ser Glu Tyr

520 525 530aac gca gaa gac tac gaa acc cgt gcc ccg aag gag gcg ttg ctt cct 1747Asn Ala Glu Asp Tyr Glu Thr Arg Ala Pro Lys Glu Ala Leu Leu Pro

535 540 545gac cag cag gtt gcc ctg ccg gtg tct ggt cac ctg cca tcc agg cgt 1795Asp Gln Gln Val Ala Leu Pro Val Ser Gly His Leu Pro Ser Arg Arg550 555 560 565cga caa gca gct gct gac ttg gcg gac ttc ttg gag ggc cgc aaa gat 1843Arg Gln Ala Ala Ala Asp Leu Ala Asp Phe Leu Glu Gly Arg Lys Asp

570 575 580tgc gac cta acc cca gta gcc cgc gcg ctg gca ggc cgc aat cat ggc 1891Cys Asp Leu Thr Pro Val Ala Arg Ala Leu Ala Gly Arg Asn His Gly

585 590 595cgc tcc cgc gca gtc gtg ctt gca agc act atc gag gaa gcc gta aag 1939Arg Ser Arg Ala Val Val Leu Ala Ser Thr Ile Glu Glu Ala Val Lys

600 605 610cgc ctg cgc cag gtc gca gaa ggc aag gtc agc gtc ggt atc tcc gca 1987Arg Leu Arg Gln Val Ala Glu Gly Lys Val Ser Val Gly Ile Ser Ala

615 620 625gct gat tcc cca gcg gcc aac ggt cct gtg ttt gtg tac tcc ggt ttc 2035Ala Asp Ser Pro Ala Ala Asn Gly Pro Val Phe Val Tyr Ser Gly Phe630 635 640 645gga tcc cag cac cgc ctc atg atc aag gaa ttg tgc tca att tcg cca 2083Gly Ser Gln His Arg Leu Met Ile Lys Glu Leu Cys Ser Ile Ser Pro

650 655 660cag ttc cgc gag cgc atc gaa gag ctc gat gaa atg gtt aag ttc gag 2131Gln Phe Arg Glu Arg Ile Glu Glu Leu Asp Glu Met Val Lys Phe Glu

665 670 675tcc ggc tgg tcc atc atg aaa ctt gtt ttg gat gat gag caa act tac 2179Ser Gly Trp Ser Ile Met Lys Leu Val Leu Asp Asp Glu Gln Thr Tyr

680 685 690gac acc gag acc gcg cag gtt gtg atc acc gca atc cag atc gca ctg 2227Asp Thr Glu Thr Ala Gln Val Val Ile Thr Ala Ile Gln Ile Ala Leu

695 700 705act gac ctg ttg gca agc ttc ggt gta aag cca gct gcc gtc atg ggc 2275Thr Asp Leu Leu Ala Ser Phe Gly Val Lys Pro Ala Ala Val Met Gly710 715 720 725atg tcg atg ggt gag atc gct gcc gct tac gct gcc ggt gga ctc agc 2323Met Ser Met Gly Glu Ile Ala Ala Ala Tyr Ala Ala Gly Gly Leu Ser

730 735 740gac cgc gat acc atg ctc att gcc agc cac cgt tcc cgc cta atg ggc 2371Asp Arg Asp Thr Met Leu Ile Ala Ser His Arg Ser Arg Leu Met Gly

745 750 755gag ggc gag aag tcc ctg gct gag gat cag ctg ggt gcc atg gct gtg 2419Glu Gly Glu Lys Ser Leu Ala Glu Asp Gln Leu Gly Ala Met Ala Val

760 765 770gtg gaa ttc gcc gct gcg gac ctg gat aag ttc atc gaa gaa aac cct 2467Val Glu Phe Ala Ala Ala Asp Leu Asp Lys Phe Ile Glu Glu Asn Pro

775 780 785gag tac aag ggc att gag cct gct gtt tat gca ggc cca ggc atg act 2515Glu Tyr Lys Gly Ile Glu Pro Ala Val Tyr Ala Gly Pro Gly Met Thr790 795 800 805acc gtg ggt gga cct cgc gac gcc gtg gtt cag ttc gta gag aag ctg 2563Thr Val Gly Gly Pro Arg Asp Ala Val Val Gln Phe Val Glu Lys Leu

810 815 820gaa tct gaa gac aag ttt gcc cgc ctg ctc aac gtc aag ggc gct ggc 2611Glu Ser Glu Asp Lys Phe Ala Arg Leu Leu Asn Val Lys Gly Ala Gly

825 830 835cac acc tct gct gtg gaa cca ctt ctt ggt gag ctc gct ggc gaa atc 2659His Thr Ser Ala Val Glu Pro Leu Leu Gly Glu Leu Ala Gly Glu Ile

840 845 850gct ggc atc gag cca ctt ccg ctg cag atc ccg ttg ttc agc tct gtc 2707Ala Gly Ile Glu Pro Leu Pro Leu Gln Ile Pro Leu Phe Ser Ser Val

855 860 865gat cag ggt gtt acc tac cca gtt gga gca gtg gtc cac gac gcc gat 2755Asp Gln Gly Val Thr Tyr Pro Val Gly Ala Val Val His Asp Ala Asp870 875 880 885tac atg ctc cgc tgt acc cgc cag tcc gtg tac ttc cag gac tcc acc 2803Tyr Met Leu Arg Cys Thr Arg Gln Ser Val Tyr Phe Gln Asp Ser Thr

890 895 900gaa gct gca ttc gct gca ggc cac aac acc ttg gtg gaa att tcc ccg 2851Glu Ala Ala Phe Ala Ala Gly His Asn Thr Leu Val Glu Ile Ser Pro

905 910 915aac cca gtt gca ctc atg ggc atg atg aac acc gcg ttc acc gtg ggc 2899Asn Pro Val Ala Leu Met Gly Met Met Asn Thr Ala Phe Thr Val Gly

920 925 930aag cct gat gca cag ctg ctg ttc agc ctg aag cga aaa gtc cca gag 2947Lys Pro Asp Ala Gln Leu Leu Phe Ser Leu Lys Arg Lys Val Pro Glu

935940 945gca gaa tcc ctc cgc gac ctt ctg gcg aag ctg tac gtc aac ggc gca 2995Ala Glu Ser Leu Arg Asp Leu Leu Ala Lys Leu Tyr Val Asn Gly Ala950 955 960 965aac gtt gat ttc tcc gcg ctg tac ggc gaa ggt gaa acc atc gat ccg 3043Asn Val Asp Phe Ser Ala Leu Tyr Gly Glu Gly Glu Thr Ile Asp Pro

970 975 980cca cac atc acc tgg aag cac cag cgc ttc tgg act tcc gca cgc cca 3091Pro His Ile Thr Trp Lys His Gln Arg Phe Trp Thr Ser Ala Arg Pro

985 990 995tcc tct ggc gca tcc ctg gat ctg ccg ggc ttc cgc gtg aat ctg cca 3139Ser Ser Gly Ala Ser Leu Asp Leu Pro Gly Phe Arg Val Asn Leu Pro

1000 1005 1010aac aac act gtg gcg ttt tcc acc gca gcc gaa ctg gca cca tcc gca 3187Asn Asn Thr Val Ala Phe Ser Thr Ala Ala Glu Leu Ala Pro Ser Ala

1015 1020 1025gtg gca atc atg gaa gca gcc gcc atg gct gtc acc cca ggt tcc tcc 3235Val Ala Ile Met Glu Ala Ala Ala Met Ala Val Thr Pro Gly Ser Ser1030 1035 1040 1045gtc gac gca gtg gac gag cgc gac atg ctg cca cca agc ggc gaa atc 3283Val Asp Ala Val Asp Glu Arg Asp Met Leu Pro Pro Ser Gly Glu Ile

1050 1055 1060acc acc atc gtg act cgc tcc ttg ggc ggt ttg agc ctg tcc gta tac 3331Thr Thr Ile Val Thr Arg Ser Leu Gly Gly Leu Ser Leu Ser Val Tyr

1065 1070 1075aag att gag gga acc acc agc act ctt gtc gcc gaa ggt ttc gca gcc 3379Lys Ile Glu Gly Thr Thr Ser Thr Leu Val Ala Glu Gly Phe Ala Ala

1080 1085 1090aac cca gga ttc gcc gca gca tct tcc ttc gac ggt cca ggc tac gac 3427Asn Pro Gly Phe AlaAla Ala Ser Ser Phe Asp Gly Pro Gly Tyr Asp

1095 1100 1105gga ttc aac acc gat tac agc gac cag cca gac cct cgc tcc gac ctg 3475Gly Phe Asn Thr Asp Tyr Ser Asp Gln Pro Asp Pro Arg Ser Asp Leu1110 1115 1120 1125cct ttg gac atc gaa gca gtc cgc tgg gac cca gcg acc gaa acc gtc 3523Pro Leu Asp Ile Glu Ala Val Arg Trp Asp Pro Ala Thr Glu Thr Val

1130 1135 1140gaa gag cgc atg cgc gcc atc gtc tcc gaa gca atg ggc tac gac gtg 3571Glu Glu Arg Met Arg Ala Ile Val Ser Glu Ala Met Gly Tyr Asp Val

1145 1150 1155gat gac ctc cca cgc gaa ctc cca ctg att gac ctc ggc ctc gac tcc 3619Asp Asp Leu Pro Arg Glu Leu Pro Leu Ile Asp Leu Gly Leu Asp Ser

1160 1165 1170ctc atg ggc atg cgc atc aaa aac cgc atc gaa aat gac ttc cag atc 3667Leu Met Gly Met Arg Ile Lys Asn Arg Ile Glu Asn Asp Phe Gln Ile

1175 1180 1185cca cca ctc cag gtc caa gcg ctc cgc gat gca tcc gtc gct gac gtg 3715Pro Pro Leu Gln Val Gln Ala Leu Arg Asp Ala Ser Val Ala Asp Val1190 1195 1200 1205gta atc atg gtg gaa aac atg gtc gct ggc cgc tcc tct gag acg ctt 3763Val Ile Met Val Glu Asn Met Val Ala Gly Arg Ser Ser Glu Thr Leu

1210 1215 1220gtc gac gcc acc ccg cag gtg cca gct gag gca gca ggg gag gct caa 3811Val Asp Ala Thr Pro Gln Val Pro Ala Glu Ala Ala Gly Glu Ala Gln

1225 1230 1235gct gct gag tct tct gct tcg ggc gag gac gtg cag ggc gtt ggc gtt 3859Ala Ala Glu Ser Ser Ala Ser Gly Glu Asp Val Gln Gly Val Gly Val

1240 12451250gca ccg cga gat gcg tcg gaa cgc atg gtc ttt ggt act tgg gca ggc 3907Ala Pro Arg Asp Ala Ser Glu Arg Met Val Phe Gly Thr Trp Ala Gly

1255 1260 1265ctg act ggc gct gcg gca gct ggc gtg acc agc aag ttg cca cag atc 3955Leu Thr Gly Ala Ala Ala Ala Gly Val Thr Ser Lys Leu Pro Gln Ile1270 1275 1280 1285gat gtc gat act gca acc gca att gcc gag cgc ctc acc gag cgt tcc 4003Asp Val Asp Thr Ala Thr Ala Ile Ala Glu Arg Leu Thr Glu Arg Ser

1290 1295 1300gga att gaa atc agc act gaa cag gtg ttg gct gca gaa acc ctc gaa 4051Gly Ile Glu Ile Ser Thr Glu Gln Val Leu Ala Ala Glu Thr Leu Glu

1305 1310 1315cca ctg tct gac ctg gtg cgt gaa ggc ctc gaa act gaa gtt cag ggc 4099Pro Leu Ser Asp Leu Val Arg Glu Gly Leu Glu Thr Glu Val Gln Gly

1320 1325 1330aac att cgt gtg ctg cgt gga cgt gca gaa ggc tcc acc aag cct gca 4147Asn Ile Arg Val Leu Arg Gly Arg Ala Glu Gly Ser Thr Lys Pro Ala

1335 1340 1345gtg ttc atg ttc cac cca gct ggc ggt tct tcc gtg gtc tac caa cca 4195Val Phe Met Phe His Pro Ala Gly Gly Ser Ser Val Val Tyr Gln Pro1350 1355 1360 1365cta atg cgt cgt ctg cct gaa gat gtc cct gtc tat ggc gtt gag cgt 4243Leu Met Arg Arg Leu Pro Glu Asp Val Pro Val Tyr Gly Val Glu Arg

1370 1375 1380ctg gaa ggc gat ctc gct gac cgc gcg gca gca tat gtt gat gac atc 4291Leu Glu Gly Asp Leu Ala Asp Arg Ala Ala Ala Tyr Val Asp Asp Ile

1385 1390 1395aag aag tac tcc gat ggc ttc cca gta gtt ttg ggt ggc tgg agc ttc 4339Lys Lys Tyr Ser Asp Gly Phe Pro Val Val Leu Gly Gly Trp Ser Phe

1400 1405 1410ggc ggt gcc gtt gcc ttc gag gtt gcc cac caa ctg gtt ggc tcc gat 4387Gly Gly Ala Val Ala Phe Glu Val Ala His Gln Leu Val Gly Ser Asp

1415 1420 1425gtt gag gta gct acc gtg gcg ttg ctg gat act gtg cag cct tca aac 4435Val Glu Val Ala Thr Val Ala Leu Leu Asp Thr Val Gln Pro Ser Asn1430 1435 1440 1445cca gca cca gat acc gct gag gaa act cgt gca cgc tgg act cgc tac 4483Pro Ala Pro Asp Thr Ala Glu Glu Thr Arg Ala Arg Trp Thr Arg Tyr

1450 1455 1460gcg gac ttc gcc aag aag acc tac ggc ctt gat ttc gag gta cct ttt 4531Ala Asp Phe Ala Lys Lys Thr Tyr Gly Leu Asp Phe Glu Val Pro Phe

1465 1470 1475gaa atc ttg gac acc atc ggt gaa gac gga atg ctg tcc atg atg acc 4579Glu Ile Leu Asp Thr Ile Gly Glu Asp Gly Met Leu Ser Met Met Thr

1480 1485 1490gac ttc ctg gcc aac acc gac gcc tcc gag cac gga ttg tcc gca ggt 4627Asp Phe Leu Ala Asn Thr Asp Ala Ser Glu His Gly Leu Ser Ala Gly

1495 1500 1505gtg ctt gaa cac cag cgc gct tct ttt gtg gac aac cgc atc ctg gct 4675Val Leu Glu His Gln Arg Ala Ser Phe Val Asp Asn Arg Ile Leu Ala1510 1515 1520 1525aaa ctt aat ttt gca gac tgg gcc aac gtt gaa gcc cct gtc atc ctg 4723Lys Leu Asn Phe Ala Asp Trp Ala Asn Val Glu Ala Pro Val Ile Leu

1530 1535 1540ttc cgc gcg gaa cgc atg cat gat gga gct atc gaa ctt gaa cca aac 4771Phe Arg Ala Glu Arg Met His Asp Gly Ala Ile Glu Leu Glu Pro Asn

1545 1550 1555tat gccaag att gat caa gat gga gga tgg tcc gga att gtc aac gat 4819Tyr Ala Lys Ile Asp Gln Asp Gly Gly Trp Ser Gly Ile Val Asn Asp

1560 1565 1570ttg gaa att gtt cag ctg aat ggt gac cac ctg gca gtt gtc gat gaa 4867Leu Glu Ile Val Gln Leu Asn Gly Asp His Leu Ala Val Val Asp Glu

1575 1580 1585cca gaa atc ggc aca gtc gga gct cat ttg agt cgc cgc att gat gag 4915Pro Glu Ile Gly Thr Val Gly Ala His Leu Ser Arg Arg Ile Asp Glu1590 1595 1600 1605att tct cgg aag aat tagtaacgga gagctgacgg aag 4953Ile Ser Arg Lys Asn

1610<210>56<211>1610<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>56Met Glu Gln Ser Gln Ser Ser Asp Gln Lys Met Thr Val Glu Gln Val 151015 Arg Thr Trp Leu Arg Asp Trp Val Val Arg Thr Thr Gly Ile Pro Val

20 25 30Glu Glu Val Thr Asp Asp Lys Ala Met Glu Thr Phe Gly Leu Ser Ser

35 40 45Arg Asp Val Val Val Leu Ser Gly Glu Leu Glu Asn Leu Leu Asp Thr

50 55 60Ser Leu Asp Ala Thr Ile Ala Tyr Glu Tyr Pro Thr Ile Arg Ser Leu 65 70 75 80Ala Gln Arg Leu Val Glu Gly Glu Pro Arg Arg Ala His Thr Gln Arg

85 90 95Glu Leu Asn Phe Ser Ala Val Ser Asp Ser Pro Gly Ser His Asp Ile

100 105 110Ala Val Val Gly Met Ala Ala Arg Tyr Pro Gly Ala Glu Ser Leu Glu

115 120 125Asp Met Trp Lys Leu Leu Val Glu Gly Arg Asp Gly Ile Ser Asp Leu

130 135 140Pro Ile Gly Arg Trp Ser Glu Tyr Ala Gly Asp Glu Val Met Ser Arg145 150 155 160Lys Met Glu Glu Phe Ser Thr Ile Gly Gly Tyr Leu Ser Asp Ile Ser

165 170 175Ser Phe Asp Ala Glu Phe Phe Gly Leu Ser Pro Leu Glu Ala Ala Asn

180 185 190Met Asp Pro Gln Gln Arg Ile Leu Leu Glu Leu Thr Trp Glu Ala Leu

195 200 205Glu Tyr Ala Arg Ile Ala Pro Asn Thr Leu Arg Gly Glu Ala Val Gly

210 215 220Val Phe Ile Gly Ser Ser Asn Asn Asp Tyr Gly Met Met Ile Ala Ala225 230 235 240Asp Pro Ala Glu Ala His Pro Tyr Ala Leu Thr Gly Thr Ser Ser Ala

245 250 255Ile Val Ala Asn Arg Ile Asn Tyr Ala Phe Asp Phe Arg Gly Pro Ser

260 265 270Val Asn Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Val His Gln

275 280 285Ala Val Arg Ala Leu Arg Asn Gly Glu Ala Asp His Ala Ile Ala Gly

290 295 300Gly Val Asn Ile Leu Ala Ser Pro Phe Val Thr Thr Ala Phe Ala Glu305 310 315 320Leu Gly Val Ile Ser Pro Thr Gly Lys Ile His Ala Phe Ser Asp Asp

325 330 335Ala Asp Gly Phe Val Arg Ser Asp Gly Ala Gly Val Val Val Leu Lys

340 345 350Arg Val Asp Asp Ala Ile Arg Asp Gly Asp Lys Ile Ile Gly Val Ile

355 360 365Lys Gly Ser Ala Val Asn Ser Asp Gly His Ser Asn Gly Leu Thr Ala

370 375 380Pro Asn Pro Asp Ala Gln Val Asp Val Leu Gln Arg Ala Tyr Val Asp385 390 395 400Ala Gln Val Asp Pro Thr Thr Val Asp Tyr Val Glu Ala His Gly Thr

405 410 415Gly Thr Ile Leu Gly Asp Pro Ile Glu Ala Thr Ala Leu Gly Ala Val

420 425 430Leu Gly Tyr Gly Arg Asp Ala Ser Thr Pro Thr Leu Leu Gly Ser Ala

435 440 445Lys Ser Asn Phe Gly His Thr Glu Ser Ala Ala Gly Ile Ala Gly Val

450 455 460Ile Lys Val Leu Leu Ala Leu Gln Asn Lys Thr Leu Pro Pro Thr Val465 470 475 480Asn Phe Ala Gly Pro Asn Arg Tyr Ile Asp Phe Asp Ala Glu Arg Leu

485 490 495Glu Val Val Glu Asp Pro Arg Glu Trp Pro Glu Tyr Asn Gly His Ala

500 505 510Val Ala Gly Val Ser Ala Phe Gly Phe Gly Gly Thr Asn Ala His Val

515 520 525Val Ile Ser Glu Tyr Asn Ala Glu Asp Tyr Glu Thr Arg Ala Pro Lys

530 535 540Glu Ala Leu Leu Pro Asp Gln Gln Val Ala Leu Pro Val Ser Gly His545 550 555 560Leu Pro Ser Arg Arg Arg Gln Ala Ala Ala Asp Leu Ala Asp Phe Leu

565 570 575Glu Gly Arg Lys Asp Cys Asp Leu Thr Pro Val Ala Arg Ala Leu Ala

580 585 590Gly Arg Asn His Gly Arg Ser Arg Ala Val Val Leu Ala Ser Thr Ile

595 600 605Glu Glu Ala Val Lys Arg Leu Arg Gln Val Ala Glu Gly Lys Val Ser

610 615 620Val Gly Ile Ser Ala Ala Asp Ser Pro Ala Ala Asn Gly Pro Val Phe625 630 635 640Val Tyr Ser Gly Phe Gly Ser Gln His Arg Leu Met Ile Lys Glu Leu

645 650 655Cys Ser Ile Ser Pro Gln Phe Arg Glu Arg Ile Glu Glu Leu Asp Glu

660 665 670Met Val Lys Phe Glu Ser Gly Trp Ser Ile Met Lys Leu Val Leu Asp

675 680 685Asp Glu Gln Thr Tyr Asp Thr Glu Thr Ala Gln Val Val Ile Thr Ala

690 695 700Ile Gln Ile Ala Leu Thr Asp Leu Leu Ala Ser Phe Gly Val Lys Pro705 710 715 720Ala Ala Val Met Gly Met Ser Met Gly Glu Ile Ala Ala Ala Tyr Ala

725 730 735Ala Gly Gly Leu Ser Asp Arg Asp Thr Met Leu Ile Ala Ser His Arg

740 745 750Ser Arg Leu Met Gly Glu Gly Glu Lys Ser Leu Ala Glu Asp Gln Leu

755 760 765Gly Ala Met Ala Val Val Glu Phe Ala Ala Ala Asp Leu Asp Lys Phe

770 775 780Ile Glu Glu Asn Pro Glu Tyr Lys Gly Ile Glu Pro Ala Val Tyr Ala785 790 795 800Gly Pro Gly Met Thr Thr Val Gly Gly Pro Arg Asp Ala Val Val Gln

805810 815Phe Val Glu Lys Leu Glu Ser Glu Asp Lys Phe Ala Arg Leu Leu Asn

820 825 830Val Lys Gly Ala Gly His Thr Ser Ala Val Glu Pro Leu Leu Gly Glu

835 840 845Leu Ala Gly Glu Ile Ala Gly Ile Glu Pro Leu Pro Leu Gln Ile Pro

850 855 860Leu Phe Ser Ser Val Asp Gln Gly Val Thr Tyr Pro Val Gly Ala Val865 870 875 880Val His Asp Ala Asp Tyr Met Leu Arg Cys Thr Arg Gln Ser Val Tyr

885 890 895Phe Gln Asp Ser Thr Glu Ala Ala Phe Ala Ala Gly His Asn Thr Leu

900 905 910Val Glu Ile Ser Pro Asn Pro Val Ala Leu Met Gly Met Met Asn Thr

915 920 925Ala Phe Thr Val Gly Lys Pro Asp Ala Gln Leu Leu Phe Ser Leu Lys

930 935 940Arg Lys Val Pro Glu Ala Glu Ser Leu Arg Asp Leu Leu Ala Lys Leu945 950 955 960Tyr Val Asn Gly Ala Asn Val Asp Phe Ser Ala Leu Tyr Gly Glu Gly

965 970 975Glu Thr Ile Asp Pro Pro His Ile Thr Trp Lys His Gln Arg Phe Trp

980 985 990Thr Ser Ala Arg Pro Ser Ser Gly Ala Ser Leu Asp Leu Pro Gly Phe

995 1000 1005Arg Val Asn Leu Pro Asn Asn Thr Val Ala Phe Ser Thr Ala Ala Glu

1010 1015 1020Leu Ala Pro Ser Ala Val Ala Ile Met Glu Ala Ala Ala Met Ala Val1025 1030 1035 1040Thr Pro Gly Ser Ser Val Asp Ala Val Asp Glu Arg Asp Met Leu Pro

1045 1050 1055Pro Ser Gly Glu Ile Thr Thr Ile Val Thr Arg Ser Leu Gly Gly Leu

1060 1065 1070Ser Leu Ser Val Tyr Lys Ile Glu Gly Thr Thr Ser Thr Leu Val Ala

1075 1080 1085Glu Gly Phe Ala Ala Asn Pro Gly Phe Ala Ala Ala Ser Ser Phe Asp

1090 1095 1100Gly Pro Gly Tyr Asp Gly Phe Asn Thr Asp Tyr Ser Asp Gln Pro Asp1105 1110 1115 1120Pro Arg Ser Asp Leu Pro Leu Asp Ile Glu Ala Val Arg Trp Asp Pro

1125 1130 1135Ala Thr Glu Thr Val Glu Glu Arg Met Arg Ala Ile Val Ser Glu Ala

1140 1145 1150Met Gly Tyr Asp Val Asp Asp Leu Pro Arg Glu Leu Pro Leu Ile Asp

1155 1160 1165Leu Gly Leu Asp Ser Leu Met Gly Met Arg Ile Lys Asn Arg Ile Glu

1170 1175 1180Asn Asp Phe Gln Ile Pro Pro Leu Gln Val Gln Ala Leu Arg Asp Ala1185 1190 1195 1200Ser Val Ala Asp Val Val Ile Met Val Glu Asn Met Val Ala Gly Arg

1205 1210 1215Ser Ser Glu Thr Leu Val Asp Ala Thr Pro Gln Val Pro Ala Glu Ala

1220 1225 1230Ala Gly Glu Ala Gln Ala Ala Glu Ser Ser Ala Ser Gly Glu Asp Val

1235 1240 1245Gln Gly Val Gly Val Ala Pro Arg Asp Ala Ser Glu Arg Met Val Phe

12501255 1260Gly Thr Trp Ala Gly Leu Thr Gly Ala Ala Ala Ala Gly Val Thr Ser1265 1270 1275 1280Lys Leu Pro Gln Ile Asp Val Asp Thr Ala Thr Ala Ile Ala Glu Arg

1285 1290 1295Leu Thr Glu Arg Ser Gly Ile Glu Ile Ser Thr Glu Gln Val Leu Ala

1300 1305 1310Ala Glu Thr Leu Glu Pro Leu Ser Asp Leu Val Arg Glu Gly Leu Glu

1315 1320 1325Thr Glu Val Gln Gly Asn Ile Arg Val Leu Arg Gly Arg Ala Glu Gly

1330 1335 1340Ser Thr Lys Pro Ala Val Phe Met Phe His Pro Ala Gly Gly Ser Ser1345 1350 1355 1360Val Val Tyr Gln Pro Leu Met Arg Arg Leu Pro Glu Asp Val Pro Val

1365 1370 1375Tyr Gly Val Glu Arg Leu Glu Gly Asp Leu Ala Asp Arg Ala Ala Ala

1380 1385 1390Tyr Val Asp Asp Ile Lys Lys Tyr Ser Asp Gly Phe Pro Val Val Leu

1395 1400 1405Gly Gly Trp Ser Phe Gly Gly Ala Val Ala Phe Glu Val Ala His Gln

1410 1415 1420Leu Val Gly Ser Asp Val Glu Val Ala Thr Val Ala Leu Leu Asp Thr1425 1430 1435 1440Val Gln Pro Ser Asn Pro Ala Pro Asp Thr Ala Glu Glu Thr Arg Ala

1445 1450 1455Arg Trp Thr Arg Tyr Ala Asp Phe Ala Lys Lys Thr Tyr Gly Leu Asp

1460 1465 1470Phe Glu Val Pro Phe Glu Ile Leu Asp Thr Ile Gly Glu Asp Gly Met

1475 14801485Leu Ser Met Met Thr Asp Phe Leu Ala Asn Thr Asp Ala Ser Glu His

1490 1495 1500Gly Leu Ser Ala Gly Val Leu Glu His Gln Arg Ala Ser Phe Val Asp1505 1510 1515 1520Asn Arg Ile Leu Ala Lys Leu Asn Phe Ala Asp Trp Ala Asn Val Glu

1525 1530 1535Ala Pro Val Ile Leu Phe Arg Ala Glu Arg Met His Asp Gly Ala Ile

1540 1545 1550Glu Leu Glu Pro Asn Tyr Ala Lys Ile Asp Gln Asp Gly Gly Trp Ser

1555 1560 1565Gly Ile Val Asn Asp Leu Glu Ile Val Gln Leu Asn Gly Asp His Leu

1570 1575 1580Ala Val Val Asp Glu Pro Glu Ile Gly Thr Val Gly Ala His Leu Ser1585 1590 1595 1600Arg Arg Ile Asp Glu Ile Ser Arg Lys Asn

16051610<210>57<211>930<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (907)<223>RXA02691<400>57cttagggctt atctgttttc cagccttgct ttttactagg cgctcctgtc ccgcttcagt 60caccaaaacc acacccctgg ttatgaccag atcggctaaa atg aac acc atg cct 115

Met Asn Thr Met Pro

1 5gac caa ccg ctc aac cag gac gga ttc cct acc gca tcc aaa ggg gtg 163Asp Gln Pro Leu Asn Gln Asp Gly Phe Pro Thr Ala Ser Lys Gly Val

10 15 20gaa ccc gac aac ctc ccc gac cgc gtt ctc gtg gac ggc ctt aaa cca 211Glu Pro Asp Asn Leu Pro Asp Arg Val Leu Val Asp Gly Leu Lys Pro

2530 35aag cat cag cag ctt cgt gaa att ttg gag gaa atc tgc acc acc cag 259Lys His Gln Gln Leu Arg Glu Ile Leu Glu Glu Ile Cys Thr Thr Gln

40 45 50ctt cag cct ggg gac atg ctg cct ggt gag cgc atc ctg gaa gaa aag 307Leu Gln Pro Gly Asp Met Leu Pro Gly Glu Arg Ile Leu Glu Glu Lys

55 60 65tat ggc gtc agc cga att acg gtt cgt cgg gcg att ggt gat ctg gtc 355Tyr Gly Val Ser Arg Ile Thr Val Arg Arg Ala Ile Gly Asp Leu Val 70 75 80 85gcg tcc ggc agg ttg aag cga gct cgc ggc aaa ggt acc ttc gtg gcc 403Ala Ser Gly Arg Leu Lys Arg Ala Arg Gly Lys Gly Thr Phe Val Ala

90 95 100cac tcg ccg ttg att tcc cgc ctg cat ttg gcc tcg ttt tcc gca gag 451His Ser Pro Leu Ile Ser Arg Leu His Leu Ala Ser Phe Ser Ala Glu

105 110 115atg gcc gcc cag aag cta tcg gct acc agc agg att ttg agt tct tcc 499Met Ala Ala Gln Lys Leu Ser Ala Thr Ser Arg Ile Leu Ser Ser Ser

120 125 130cgc ggt ccc gcc cca gat gat att gct gat ttc ttt ggt acc gat cgc 547Arg Gly Pro Ala Pro Asp Asp Ile Ala Asp Phe Phe Gly Thr Asp Arg

135 140 145gcg gcc cag cac atc acg ttg cgc cgc ctg cgc ttt gga aat ggt cga 595Ala Ala Gln His Ile Thr Leu Arg Arg Leu Arg Phe Gly Asn Gly Arg150 155 160 165ccc tat gcc att gac aac ggt tgg tac aac tcc gaa ttc gca cct gac 643Pro Tyr Ala Ile Asp Asn Gly Trp Tyr Asn Ser Glu Phc Ala Pro Asp

170 175 180ctg ctg gaa aat gat gtg tac aac tcc gtg tac tcc atc ctg gac cgc 691Leu Leu Glu AsnAsp Val Tyr Asn Ser Val Tyr Ser Ile Leu Asp Arg

185 190 195gtc tat ggc gtc ccc gtc acc cag gcc gag caa acg gtc acc gcc gta 739Val Tyr Gly Val Pro Val Thr Gln Ala Glu Gln Thr Val Thr Ala Val

200 205 210gca gcc gac gaa gac acc gca cgg ctt ctg gac gtc acc ccc ggc gcc 787Ala Ala Asp Glu Asp Thr Ala Arg Leu Leu Asp Val Thr Pro Gly Ala

215 220 225cca ctc ctt cgt atc ctt cga cag tca ctt tct ggc gat aag ccc gtg 835Pro Leu Leu Arg Ile Leu Arg Gln Ser Leu Ser Gly Asp Lys Pro Val230 235 240 245gaa tgg tgc gtt tcc ttg tac cga acc gac cga tat tct tta aaa aca 883Glu Trp Cys Val Ser Leu Tyr Arg Thr Asp Arg Tyr Ser Leu Lys Thr

250 255 260ttg gtt aca cgc tcc gaa gat ctc tgacgtgaac ccattttggt ggc 930Leu Val Thr Arg Ser Glu Asp Leu

265<210>58<211>269<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>58Met Asn Thr Met Pro Asp Gln Pro Leu Asn Gln Asp Gly Phe Pro Thr 151015 Ala Ser Lys Gly Val Glu Pro Asp Asn Leu Pro Asp Arg Val Leu Val

20 25 30Asp Gly Leu Lys Pro Lys His Gln Gln Leu Arg Glu Ile Leu Glu Glu

35 40 45Ile Cys Thr Thr Gln Leu Gln Pro Gly Asp Met Leu Pro Gly Glu Arg

50 55 60Ile Leu Glu Glu Lys Tyr Gly Val Ser Arg Ile Thr Val Arg Arg Ala 65 70 75 80Ile Gly Asp Leu Val Ala Ser Gly Arg Leu Lys Arg Ala Arg Gly Lys

85 9095Gly Thr Phe Val Ala His Ser Pro Leu Ile Ser Arg Leu His Leu Ala

100 105 110Ser Phe Ser Ala Glu Met Ala Ala Gln Lys Leu Ser Ala Thr Ser Arg

115 120 125Ile Leu Ser Ser Ser Arg Gly Pro Ala Pro Asp Asp Ile Ala Asp Phe

130 135 140Phe Gly Thr Asp Arg Ala Ala Gln His Ile Thr Leu Arg Arg Leu Arg145 150 155 160Phe Gly Asn Gly Arg Pro Tyr Ala Ile Asp Asn Gly Trp Tyr Asn Ser

165 170 175Glu Phe Ala Pro Asp Leu Leu Glu Asn Asp Val Tyr Asn Ser Val Tyr

180 185 190Ser Ile Leu Asp Arg Val Tyr Gly Val Pro Val Thr Gln Ala Glu Gln

195 200 205Thr Val Thr Ala Val Ala Ala Asp Glu Asp Thr Ala Arg Leu Leu Asp

210 215 220Val Thr Pro Gly Ala Pro Leu Leu Arg Ile Leu Arg Gln Ser Leu Ser225 230 235 240Gly Asp Lys Pro Val Glu Trp Cys Val Ser Leu Tyr Arg Thr Asp Arg

245 250 255Tyr Ser Leu Lys Thr Leu Val Thr Arg Ser Glu Asp Leu

260265<210>59<211>1968<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1945)<223>RXA00880<400>59tccatgtggt taaagatatg cctaaagatc tgaccaaaaa cgtgactaaa gacgtgacga 60cacaagtaca gccaaattaa aggaaaggtt gaatttgacc atg act tca cct aat 115

Met Thr Ser Pro Asn

1 5acc ctg cag gaa tac act gaa cct gcc aag tac acc atc gga gaa tct 163Thr Leu Gln Glu Tyr Thr Glu Pro Ala Lys Tyr Thr Ile Gly Glu Ser

10 15 20gaa acc tgc ctg acc gcc ctt cta gat cag att aag act cga cct tac 211Glu Thr Cys Leu Thr Ala Leu Leu Asp Gln Ile Lys Thr Arg Pro Tyr

25 30 35gga gtt ttg ttc agc aag cct gcc aac tat gag tgg gtg aat gta act 259Gly Val Leu Phe Ser Lys Pro Ala Asn Tyr Glu Trp Val Asn Val Thr

40 45 50gcc aaa gaa ttt cag gac gag gtt ttt gcg gtt gca aaa gga att att 307Ala Lys Glu Phe Gln Asp Glu Val Phe Ala Val Ala Lys Gly Ile Ile

55 60 65tca gtc ggc gta gag cag gga gac cgt gtc gcg ctg ctg tcc aat act 355Ser Val Gly Val Glu Gln Gly Asp Arg Val Ala Leu Leu Ser Asn Thr 70 75 80 85cgc tat gag tgg gct gtg ctt gat ttc gct atc tgg gcc gct ggc gca 403Arg Tyr Glu Trp Ala Val Leu Asp Phe Ala Ile Trp Ala Ala Gly Ala

90 95 100gtg agc gtg cct atc tac agc tcc tct tca ctg tcc caa att gag tgg 451Val Ser Val Pro Ile Tyr Ser Ser Ser Ser Leu Ser Gln Ile Glu Trp

105 110 115atc att gag gat tcc ggc gct gtt ttg gcc att acc gaa acc cct gat 499Ile Ile Glu Asp Ser Gly Ala Val Leu Ala Ile Thr Glu Thr Pro Asp

120 125 130cat acc gac ttg atg aag aac ctg gtc atc ggt gaa gac gga act cca 547His Thr Asp Leu Met Lys Asn Leu Val Ile Gly Glu Asp Gly Thr Pro

135 140 145gcg att aag ggt tca cct tcc aag ctg cgc cgc att cta gag atc aac 595Ala Ile Lys Gly Ser Pro Ser Lys Leu Arg Arg Ile Leu Glu Ile Asn150 155 160 165tct tcg gcg ttg gag acc ttg aag ttt gag ggc cgc gag ctt tct gat 643Ser Ser Ala Leu Glu Thr Leu Lys Phe Glu Gly Arg Glu Leu Ser Asp

170 175 180gag ctg gtg tgg gaa cgc att cat gca acc aag gcc gct gac ctg gcg 691Glu Leu Val Trp Glu Arg Ile His Ala Thr Lys Ala Ala Asp Leu Ala

185 190 195tct ttg gtg tac acc tct ggc aca act ggt agg ccg aag ggc tgc gag 739Ser Leu Val Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Cys Glu

200 205 210ttg tcc cac tac cac tgg ttg gct gag gtc cga gcg ctg atc acc aat 787Leu Ser His Tyr His Trp Leu Ala Glu Val Arg Ala Leu Ile Thr Asn

215 220 225gac atc gga gcg atc gcg atg cca ggt tca agg ttg ctc acc ttc ctt 835Asp Ile Gly Ala Ile Ala Met Pro Gly Ser Arg Leu Leu Thr Phe Leu230 235 240 245cct ttg gcg cac gtt ctt gct cgc gca gtg cac ttg gcc ttc gct gtc 883Pro Leu Ala His Val Leu Ala Arg Ala Val His Leu Ala Phe Ala Val

250 255 260acc ggt gca acc cag tcc cac tgg tct gat ttc agc acc ctt act ttg 931Thr Gly Ala Thr Gln Ser His Trp Ser Asp Phe Ser Thr Leu Thr Leu

265 270 275gaa ctg cag cgt tcc cgc ccg aac ctg att ttg ggt gtt cca cgc gtg 979Glu Leu Gln Arg Ser Arg Pro Asn Leu Ile Leu Gly Val Pro Arg Val

280 285 290ttt gaa aag gtc cgc aac gcc gct gct gct aat gct gct gac ggt ggc 1027Phe Glu Lys Val Arg Asn Ala Ala Ala Ala Asn Ala Ala Asp Gly Gly

295300 305gca atc aag cgc atc atg ttt gag cgt gcc gaa aag gcg gcc att gaa 1075Ala Ile Lys Arg Ile Met Phe Glu Arg Ala Glu Lys Ala Ala Ile Glu310 315 320 325tac tcc atg gct ctt gat act gca gaa ggc cca agc aag tcc cag gtt 1123Tyr Ser Met Ala Leu Asp Thr Ala Glu Gly Pro Ser Lys Ser Gln Val

330 335 340atg gca cat aaa gcg ttt gac aag ctg gtg tac tcc aag atc cgt gca 1171Met Ala His Lys Ala Phe Asp Lys Leu Val Tyr Ser Lys Ile Arg Ala

345 350 355gct gtc ggt ggc gat gtg cag tac gcc atc acc ggt ggt tca gcg atg 1219Ala Val Gly Gly Asp Val Gln Tyr Ala Ile Thr Gly Gly Ser Ala Met

360 365 370ggg cag gag ctg ctg cac ttc ttc cgc ggt gtg ggc atg acc atc tac 1267Gly Gln Glu Leu Leu His Phe Phe Arg Gly Val Gly Met Thr Ile Tyr

375 380 385gaa ggt tat ggt ctg acg gaa tct gcg gct gct gca gcg gtg gac ttc 1315Glu Gly Tyr Gly Leu Thr Glu Ser Ala Ala Ala Ala Ala Val Asp Phe390 395 400 405act gat caa aag atc ggc act gtg ggt aag ccg atg ggt ggc atg acc 1363Thr Asp Gln Lys Ile Gly Thr Val Gly Lys Pro Met Gly Gly Met Thr

410 415 420atc aag atc aat gaa gat ggc gaa atc atg cta aaa ggc gag atg ttg 1411Ile Lys Ile Asn Glu Asp Gly Glu Ile Met Leu Lys Gly Glu Met Leu

425 430 435ttc cag gga tat tgg aac aac cca gaa gcc aca gca gaa gcc ctc cac 1459Phe Gln Gly Tyr Trp Asn Asn Pro Glu Ala Thr Ala Glu Ala Leu His

440 445 450gac ggt tgg ttc aac acc ggc gat ctg ggt gag ctg ttg gag tct gga 1507Asp Gly Trp Phe Asn Thr Gly Asp Leu Gly Glu Leu Leu Glu Ser Gly

455 460 465cac ctg gtg atc acc gga cgt aag aaa gat ctg atc gtg acc gcg ggc 1555His Leu Val Ile Thr Gly Arg Lys Lys Asp Leu Ile Val Thr Ala Gly470 475 480 485ggc aag aac gtt tcc cca gga ccc atg gaa gac atc atc cgc gca cac 1603Gly Lys Asn Val Ser Pro Gly Pro Met Glu Asp Ile Ile Arg Ala His

490 495 500cca ctg gtc agc cag gcc atg gtg gtg ggc gat ggt aaa cca ttc gtt 1651Pro Leu Val Ser Gln Ala Met Val Val Gly Asp Gly Lys Pro Phe Val

505 510 515ggc ctg ctg gtg acc ttg gat cca gat atg ttg aag cgg tgg aag ctg 1699Gly Leu Leu Val Thr Leu Asp Pro Asp Met Leu Lys Arg Trp Lys Leu

520 525 530aac cac aac att gcg gaa tcc cgc acg gtt tct gag att gct act gat 1747Asn His Asn Ile Ala Glu Ser Arg Thr Val Ser Glu Ile Ala Thr Asp

535 540 545cct gca ctg cgt gcg gaa atc cag gat gca gtc aac aac gct aat gcc 1795Pro Ala Leu Arg Ala Glu Ile Gln Asp Ala Val Asn Asn Ala Asn Ala550 555 560 565acg gtg tct cat tca gag gcg atc aag cgg ttc tac atc ctt gat cgc 1843Thr Val Ser His Ser Glu Ala Ile Lys Arg Phe Tyr Ile Leu Asp Arg

570 575 580gac ctg acc gag gaa gcc gac gag ctg acc cca acg ctg aag gtc aag 1891Asp Leu Thr Glu Glu Ala Asp Glu Leu Thr Pro Thr Leu Lys Val Lys

585 590 595cgc aac gtt gtt gtt cgc cgt tac gca gac gcc atc gac cac atc tac 1939Arg Asn Val Val Val Arg Arg Tyr Ala Asp Ala Ile Asp His Ile Tyr

600605 610aac cga tgagtaacac agagacccaa ttt 1968Asn Arg

615<210>60<211>615<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>60Met Thr Ser Pro Asn Thr Leu Gln Glu Tyr Thr Glu Pro Ala Lys Tyr 151015 Thr Ile Gly Glu Ser Glu Thr Cys Leu Thr Ala Leu Leu Asp Gln Ile

20 25 30Lys Thr Arg Pro Tyr Gly Val Leu Phe Ser Lys Pro Ala Asn Tyr Glu

35 40 45Trp Val Asn Val Thr Ala Lys Glu Phe Gln Asp Glu Val Phe Ala Val

50 55 60Ala Lys Gly Ile Ile Ser Val Gly Val Glu Gln Gly Asp Arg Val Ala 65 70 75 80Leu Leu Ser Asn Thr Arg Tyr Glu Trp Ala Val Leu Asp Phe Ala Ile

85 90 95Trp Ala Ala Gly Ala Val Ser Val Pro Ile Tyr Ser Ser Ser Ser Leu

100 105 110Ser Gln Ile Glu Trp Ile Ile Glu Asp Ser Gly Ala Val Leu Ala Ile

115 120 125Thr Glu Thr Pro Asp His Thr Asp Leu Met Lys Asn Leu Val Ile Gly

130 135 140Glu Asp Gly Thr Pro Ala Ile Lys Gly Ser Pro Ser Lys Leu Arg Arg145 150 155 160Ile Leu Glu Ile Asn Ser Ser Ala Leu Glu Thr Leu Lys Phe Glu Gly

165 170 175Arg Glu Leu Ser Asp Glu Leu Val Trp Glu Arg Ile His Ala Thr Lys

180 185 190Ala Ala Asp Leu Ala Ser Leu Val Tyr Thr Ser Gly Thr Thr Gly Arg

195 200 205Pro Lys Gly Cys Glu Leu Ser His Tyr His Trp Leu Ala Glu Val Arg

210 215 220Ala Leu Ile Thr Asn Asp Ile Gly Ala Ile Ala Met Pro Gly Ser Arg225 230 235 240Leu Leu Thr Phe Leu Pro Leu Ala His Val Leu Ala Arg Ala Val His

245 250 255Leu Ala Phe Ala Val Thr Gly Ala Thr Gln Ser His Trp Ser Asp Phe

260 265 270Ser Thr Leu Thr Leu Glu Leu Gln Arg Ser Arg Pro Asn Leu Ile Leu

275 280 285Gly Val Pro Arg Val Phe Glu Lys Val Arg Asn Ala Ala Ala Ala Asn

290 295 300Ala Ala Asp Gly Gly Ala Ile Lys Arg Ile Met Phe Glu Arg Ala Glu305 310 315 320Lys Ala Ala Ile Glu Tyr Ser Met Ala Leu Asp Thr Ala Glu Gly Pro

325 330 335Ser Lys Ser Gln Val Met Ala His Lys Ala Phe Asp Lys Leu Val Tyr

340 345 350Ser Lys Ile Arg Ala Ala Val Gly Gly Asp Val Gln Tyr Ala Ile Thr

355 360 365Gly Gly Ser Ala Met Gly Gln Glu Leu Leu His Phe Phe Arg Gly Val

370 375 380Gly Met Thr Ile Tyr Glu Gly Tyr Gly Leu Thr Glu Ser Ala Ala Ala385 390 395 400Ala Ala Val Asp Phe Thr Asp Gln Lys Ile Gly Thr Val Gly Lys Pro

405 410 415Met Gly Gly Met Thr Ile Lys Ile Asn Glu Asp Gly Glu Ile Met Leu

420 425 430Lys Gly Glu Met Leu Phe Gln Gly Tyr Trp Asn Asn Pro Glu Ala Thr

435 440 445Ala Glu Ala Leu His Asp Gly Trp Phe Asn Thr Gly Asp Leu Gly Glu

450 455 460Leu Leu Glu Ser Gly His Leu Val Ile Thr Gly Arg Lys Lys Asp Leu465 470 475 480Ile Val Thr Ala Gly Gly Lys Asn Val Ser Pro Gly Pro Met Glu Asp

485 490 495Ile Ile Arg Ala His Pro Leu Val Ser Gln Ala Met Val Val Gly Asp

500 505 510Gly Lys Pro Phe Val Gly Leu Leu Val Thr Leu Asp Pro Asp Met Leu

515 520 525Lys Arg Trp Lys Leu Asn His Asn Ile Ala Glu Ser Arg Thr Val Ser

530 535 540Glu Ile Ala Thr Asp Pro Ala Leu Arg Ala Glu Ile Gln Asp Ala Val545 550 555 560Asn Asn Ala Asn Ala Thr Val Ser His Ser Glu Ala Ile Lys Arg Phe

565 570 575Tyr Ile Leu Asp Arg Asp Leu Thr Glu Glu Ala Asp Glu Leu Thr Pro

580 585 590Thr Leu Lys Val Lys Arg Asn Val Val Val Arg Arg Tyr Ala Asp Ala

595 600 605Ile Asp His Ile Tyr Asn Arg

610615<210>61<211>1047<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1024)<223>RXA01060<400>61ttccatttac acatctgttc gactcgcgcc cgaatgatgt cgcatcaaca tgagaagcta 60cttccatact tttactgatt gataagaatg gacaaagaca atg aac cgc acactc 115

Met Asn Arg Thr Leu

1 5cga aca ctt ggc tgg ctt gct gcc gta att caa gaa gat ccg gag ccc 163Arg Thr Leu Gly Trp Leu Ala Ala Val Ile Gln Glu Asp Pro Glu Pro

10 15 20tgg ttc acc act gat ccc gac acc gat tat gtc cct tat gta aat agt 211Trp Phe Thr Thr Asp Pro Asp Thr Asp Tyr Val Pro Tyr Val Asn Ser

25 30 35ttc tca ttt gaa tcc ctt tcc ctc gtt cca gat gct ctg atg ctg ctc 259Phe Ser Phe Glu Ser Leu Ser Leu Val Pro Asp Ala Leu Met Leu Leu

40 45 50aaa cgt tct ctt cac ctt gcg atg gag caa cag gac ctc cca gtg aag 307Lys Arg Ser Leu His Leu Ala Met Glu Gln Gln Asp Leu Pro Val Lys

55 60 65gat cta caa gaa gca ctg agg cac gta cta gtt ttc aaa ttc cac ttc 355Asp Leu Gln Glu Ala Leu Arg His Val Leu Val Phe Lys Phe His Phe 70 75 80 85agg gaa gaa tgg gag ctg gaa tta gca tgg gac tcc gag cgg acc aag 403Arg Glu Glu Trp Glu Leu Glu Leu Ala Trp Asp Ser Glu Arg Thr Lys

90 95 100tct gcg gtg aga att att gag agc aca aaa gaa tct ctt gcc gat caa 451Ser Ala Val Arg Ile Ile Glu Ser Thr Lys Glu Ser Leu Ala Asp Gln

105 110 115tac aga gat tac aaa tac gca ttc ttg cct gag cta att ttc cag gaa 499Tyr Arg Asp Tyr Lys Tyr Ala Phe Leu Pro Glu Leu Ile Phe Gln Glu

120 125 130tca cgc ggg atc ttt gac ttt gag ctg gag gga tac acc ctc aaa gta 547Ser Arg Gly Ile Phe Asp Phe Glu Leu Glu Gly Tyr Thr Leu Lys Val

135 140 145gga caa agc acg ctt tcc att cct tgg gac atg atc gcc aat ggt tat 595Gly Gln Ser Thr Leu Ser Ile Pro Trp Asp Met Ile Ala Asn Gly Tyr150 155 160 165gtc cct gca agt ctt cgg aat ttt gga gaa tta atg gac cgt gac acc 643Val Pro Ala Ser Leu Arg Asn Phe Gly Glu Leu Met Asp Arg Asp Thr

170 175 180gga gat ctt gat gca gat ccc att ctg aga cct cga gaa ctc aaa ttt 691Gly Asp Leu Asp Ala Asp Pro Ile Leu Arg Pro Arg Glu Leu Lys Phe

185 190 195gag atc cat aat tgt cca gat ctt aat cct tgg ata atg cgg gaa act 739Glu Ile His Asn Cys Pro Asp Leu Asn Pro Trp Ile Met Arg Glu Thr

200 205 210ttt gat ttc atg atg gaa atc gca act gaa aca gga tgg ttc cat gct 787Phe Asp Phe Met Met Glu Ile Ala Thr Glu Thr Gly Trp Phe His Ala

215 220 225ctc aac ccc gca tat aat tcc gtc tac acc tac gat ctt att tct cgc 835Leu Asn Pro Ala Tyr Asn Ser Val Tyr Thr Tyr Asp Leu Ile Ser Arg230 235 240 245atg cca gat ttc ctt gtt gaa ggg agc ttt cgt ccg cat tca gtg aaa 883Met Pro Asp Phe Leu Val Glu Gly Ser Phe Arg Pro His Ser Val Lys

250 255 260cga tct tgg gaa aaa att caa aag ata gct aaa gct gtt gag tct tat 931Arg Ser Trp Glu Lys Ile Gln Lys Ile Ala Lys Ala Val Glu Ser Tyr

265 270 275gca tct cac gat tac tgc atg tca acg ctg aca cat gac tac agg gca 979Ala Ser His Asp Tyr Cys Met Ser Thr Leu Thr His Asp Tyr Arg Ala

280 285 290atc gag tta tcc ctg acg cctaca aaa act gag gaa cca agc aca 1024Ile Glu Leu Ser Leu Thr Pro Thr Lys Thr Glu Glu Pro Ser Thr

295300305 taagaaaacc tcgcctgccc act 1047<210>62<211>308<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>62Met Asn Arg Thr Leu Arg Thr Leu Gly Trp Leu Ala Ala Val Ile Gln 151015 Glu Asp Pro Glu Pro Trp Phe Thr Thr Asp Pro Asp Thr Asp Tyr Val

20 25 30Pro Tyr Val Asn Ser Phe Ser Phe Glu Ser Leu Ser Leu Val Pro Asp

35 40 45Ala Leu Met Leu Leu Lys Arg Ser Leu His Leu Ala Met Glu Gln Gln

50 55 60Asp Leu Pro Val Lys Asp Leu Gln Glu Ala Leu Arg His Val Leu Val 65 70 75 80Phe Lys Phe His Phe Arg Glu Glu Trp Glu Leu Glu Leu Ala Trp Asp

85 90 95Ser Glu Arg Thr Lys Ser Ala Val Arg Ile Ile Glu Ser Thr Lys Glu

100 105 110Ser Leu Ala Asp Gln Tyr Arg Asp Tyr Lys Tyr Ala Phe Leu Pro Glu

115 120 125Leu Ile Phe Gln Glu Ser Arg Gly Ile Phe Asp Phe Glu Leu Glu Gly

130 135 140Tyr Thr Leu Lys Val Gly Gln Ser Thr Leu Ser Ile Pro Trp Asp Met145 150 155 160Ile Ala Asn Gly Tyr Val Pro Ala Ser Leu Arg Asn Phe Gly Glu Leu

165 170 175Met Asp Arg Asp Thr Gly Asp Leu Asp Ala Asp Pro Ile Leu Arg Pro

180 185 190Arg Glu Leu Lys Phe Glu Ile His Asn Cys Pro Asp Leu Asn Pro Trp

195 200 205Ile Met Arg Glu Thr Phe Asp Phe Met Met Glu Ile Ala Thr Glu Thr

210 215 220Gly Trp Phe His Ala Leu Asn Pro Ala Tyr Asn Ser Val Tyr Thr Tyr225 230 235 240Asp Leu Ile Ser Arg Met Pro Asp Phe Leu Val Glu Gly Ser Phe Arg

245 250 255Pro His Ser Val Lys Arg Ser Trp Glu Lys Ile Gln Lys Ile Ala Lys

260 265 270Ala Val Glu Ser Tyr Ala Ser His Asp Tyr Cys Met Ser Thr Leu Thr

275 280 285His Asp Tyr Arg Ala Ile Glu Leu Ser Leu Thr Pro Thr Lys Thr Glu

290295300 Glu Pro Ser Thr305<210>63<211>1848<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1825)<223>RXN01722<400>63ctcattcccc tcgctaaaag ctgcataaag tttcgacgtt ttcaaagttg attgcttgca 60ctgtcgttgc gtgtcgcatg ccccggctat tgttgattgc atg ctc agc acg atg 115

Met Leu Ser Thr Met

1 5cag gac gtc cca ctg tca tta acc aga atc ctc gag tac ggg tcc act 163Gln Asp Val Pro Leu Ser Leu Thr Arg Ile Leu Glu Tyr Gly Ser Thr

10 15 20gtt cac ggt gat act ttg atc acc acg tgg ggc ggt gcc gat ggc att 211Val His Gly Asp Thr Leu Ile Thr Thr Trp Gly Gly Ala Asp Gly Ile

25 30 35gaa caa gca cag caa act ttt agt gct gtg ggg gct aga gct gcg gct 259Glu Gln Ala Gln Gln Thr Phe Ser Ala Val Gly Ala Arg Ala Ala Ala

40 45 50ttg gct cat gcg ctg cat gat tct tta ggt att act ggg gat cag cga 307Leu Ala His Ala Leu His Asp Ser Leu Gly Ile Thr Gly Asp Gln Arg

55 60 65gtg gcg tcg atg ctc tat aac tgc gcg gaa cac atg gaa act atg ttt 355Val Ala Ser Met Leu Tyr Asn Cys Ala Glu His Met Glu Thr Met Phe 70 75 80 85gca gtc gca tgc atg ggt gcc gtg ttt aat ccg ctg aac aag cag ttg 403Ala Val Ala Cys Met Gly Ala Val Phe Asn Pro Leu Asn Lys Gln Leu

90 95 100atg aat gat cag att gtg ttc att ctc aat cac tct gaa gct gaa gtg 451Met Asn Asp Gln Ile Val Phe Ile Leu Asn His Ser Glu Ala Glu Val

105 110 115gtt atc gct gat ccg cgc atg gct gaa caa ttg ggt gag atc tta aaa 499Val Ile Ala Asp Pro Arg Met Ala Glu Gln Leu Gly Glu Ile Leu Lys

120 125 130gaa aca cca aaa gtt cgt gcc gtg gtg ttt att gga ccg aat gat ttc 547Glu Thr Pro Lys Val Arg Ala Val Val Phe Ile Gly Pro Asn Asp Phe

135 140 145tct agc gcg gcg gcc cac atg ccg gag gga atg aag ctg tat tcc tat 595Ser Ser Ala Ala Ala His Met Pro Glu Gly Met Lys Leu Tyr Ser Tyr150 155 160 165gaa gcg ctc ctt gac ggc cgt tcc act gtt tac aac tgg ccc gag cag 643Glu Ala Leu Leu Asp Gly Arg Ser Thr Val Tyr Asn Trp Pro Glu Gln

170 175 180gat gaa cgc act gct gct gca att tgc tat tcc acc ggt aca tcg gga 691Asp Glu Arg Thr Ala Ala Ala Ile Cys Tyr Ser Thr Gly Thr Ser Gly

185 190 195ccg ccg aag ggt gtggtg tat tcc cac cgc tcg ctt tat tta cag tcg 739Pro Pro Lys Gly Val Val Tyr Ser His Arg Ser Leu Tyr Leu Gln Ser

200 205 210ttg agc ttg cgc acc acg gat tcc ctc gca gtg gaa cac ggc gaa acg 787Leu Ser Leu Arg Thr Thr Asp Ser Leu Ala Val Glu His Gly Glu Thr

215 220 225ttc ctg tgc tgt gtg ccg att tac cac gtc ctc agc tgg ggc gtg ccg 835Phe Leu Cys Cys Val Pro Ile Tyr His Val Leu Ser Trp Gly Val Pro230 235 240 245atc gca gcg ttt atg tcc ggc act ccc ctg gtg ctt cct gga ccg gat 883Ile Ala Ala Phe Met Ser Gly Thr Pro Leu Val Leu Pro Gly Pro Asp

250 255 260ctt tct gcg ccg aca ttg gca aag atc att tcc acc acg ctg cct cgc 931Leu Ser Ala Pro Thr Leu Ala Lys Ile Ile Ser Thr Thr Leu Pro Arg

265 270 275gtg gcg cat ggc gtg cct act ctc tgg att cag ctg atg gtt cac tac 979Val Ala His Gly Val Pro Thr Leu Trp Ile Gln Leu Met Val His Tyr

280 285 290ctg aaa aat ccc cca gag cgt atg tct ctg cgt gag cta tac gtg ggc 1027Leu Lys Asn Pro Pro Glu Arg Met Ser Leu Arg Glu Leu Tyr Val Gly

295 300 305ggt tct gcg gtg cct cca atc gtg atc acc atg tgg gag cag cgc tat 1075Gly Ser Ala Val Pro Pro Ile Val Ile Thr Met Trp Glu Gln Arg Tyr310 315 320 325ggc gtg gat gtt gtc cac gtg tgg ggt atg acg gaa acc tcc acc gtg 1123Gly Val Asp Val Val His Val Trp Gly Met Thr Glu Thr Ser Thr Val

330 335 340ggt act gtg tct cgc cca cca tca ggt gtt tct ggt gaa agc cgg tgg 1171Gly Thr Val Ser Arg Pro Pro Ser Gly Val Ser Gly Glu Ser Arg Trp

345 350 355aat tat cga gtc tcc cag ggc cga ttc ccc gcc tcc ctg cag tac cgc 1219Asn Tyr Arg Val Ser Gln Gly Arg Phe Pro Ala Ser Leu Gln Tyr Arg

360 365 370att gtc aac gac ggc cag gtc atg gcg tcc acc gac cgc aac gag ggc 1267Ile Val Asn Asp Gly Gln Val Met Ala Ser Thr Asp Arg Asn Glu Gly

375 380 385gag att cag gtc cgc ggt ccg tgg gtg act gca agt tac ttc cac ccc 1315Glu Ile Gln Val Arg Gly Pro Trp Val Thr Ala Ser Tyr Phe His Pro390 395 400 405gat gtg gaa aaa gaa ggt ggc acc gcc tca aca ttc cgc gac cat gac 1363Asp Val Glu Lys Glu Gly Gly Thr Ala Ser Thr Phe Arg Asp His Asp

410 415 420gtt gaa gag gaa aac gat gag ctc ttc acc gcc gac ggc tgg ctg cgc 1411Val Glu Glu Glu Asn Asp Glu Leu Phe Thr Ala Asp Gly Trp Leu Arg

425 430 435acc ggg gac gtt gga tct gtc acc agc gat gga ttc ctc acc atc caa 1459Thr Gly Asp Val Gly Ser Val Thr Ser Asp Gly Phe Leu Thr Ile Gln

440 445 450gac cgc gcc cgc gat gtc atc cgt tct ggc ggc gag tgg att tac tcc 1507Asp Arg Ala Arg Asp Val Ile Arg Ser Gly Gly Glu Trp Ile Tyr Ser

455 460 465gct cag ctg gaa aac ctc atc gtg gct acg gaa gag gtt gtc gaa tgc 1555Ala Gln Leu Glu Asn Leu Ile Val Ala Thr Glu Glu Val Val Glu Cys470 475 480 485gcc gtc att ggc ttc ccc gat gac aag tgg gtg gaa cgt ccc ctc gca 1603Ala Val Ile Gly Phe Pro Asp Asp Lys Trp Val Glu Arg Pro Leu Ala

490 495 500gtc acc atg ctc tac ccc ggc att gaa cgc acccgg gaa acc gcc gag 1651Val Thr Met Leu Tyr Pro Gly Ile Glu Arg Thr Arg Glu Thr Ala Glu

505 510 515cgc ctc cgc gat caa ctt cgc gac cgc cta ccc aac tgg atg ctg cca 1699Arg Leu Arg Asp Gln Leu Arg Asp Arg Leu Pro Asn Trp Met Leu Pro

520 525 530gaa tat tgg aca ttt gtt gat gag gtg gat aaa acc tcc gtc ggt aaa 1747Glu Tyr Trp Thr Phe Val Asp Glu Val Asp Lys Thr Ser Val Gly Lys

535 540 545tat gac aag aag gac ctc cgc aac cac ctg cgc aac ggc gat ttc gaa 1795Tyr Asp Lys Lys Asp Leu Arg Asn His Leu Arg Asn Gly Asp Phc Glu550 555 560 565gta att aag ctt aaa ggg cca ggt gaa aaa taacttccct atttattccg 1845Val Ile Lys Leu Lys Gly Pro Gly Glu Lys

570575 gct1848<210>64<211>575<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>64Met Leu Ser Thr Met Gln Asp Val Pro Leu Ser Leu Thr Arg Ile Leu 151015 Glu Tyr Gly Ser Thr Val His Gly Asp Thr Leu Ile Thr Thr Trp Gly

20 25 30Gly Ala Asp Gly Ile Glu Gln Ala Gln Gln Thr Phe Ser Ala Val Gly

35 40 45Ala Arg Ala Ala Ala Leu Ala His Ala Leu His Asp Ser Leu Gly Ile

50 55 60Thr Gly Asp Gln Arg Val Ala Ser Met Leu Tyr Asn Cys Ala Glu His 65 70 75 80Met Glu Thr Met Phe Ala Val Ala Cys Met Gly Ala Val Phe Asn Pro

85 90 95Leu Asn Lys Gln Leu Met Asn Asp Gln Ile Val Phe Ile Leu Asn His

100 105 110Ser Glu Ala Glu Val Val Ile Ala Asp Pro Arg Met Ala Glu Gln Leu

115 120 125Gly Glu Ile Leu Lys Glu Thr Pro Lys Val Arg Ala Val Val Phe Ile

130 135 140Gly Pro Asn Asp Phe Ser Ser Ala Ala Ala His Met Pro Glu Gly Met145 150 155 160Lys Leu Tyr Ser Tyr Glu Ala Leu Leu Asp Gly Arg Ser Thr Val Tyr

165 170 175Asn Trp Pro Glu Gln Asp Glu Arg Thr Ala Ala Ala Ile Cys Tyr Ser

180 185 190Thr Gly Thr Ser Gly Pro Pro Lys Gly Val Val Tyr Ser His Arg Ser

195 200 205Leu Tyr Leu Gln Ser Leu Ser Leu Arg Thr Thr Asp Ser Leu Ala Val

210 215 220Glu His Gly Glu Thr Phe Leu Cys Cys Val Pro Ile Tyr His Val Leu225 230 235 240Ser Trp Gly Val Pro Ile Ala Ala Phe Met Ser Gly Thr Pro Leu Val

245 250 255Leu Pro Gly Pro Asp Leu Ser Ala Pro Thr Leu Ala Lys Ile Ile Ser

260 265 270Thr Thr Leu Pro Arg Val Ala His Gly Val Pro Thr Leu Trp Ile Gln

275 280 285Leu Met Val His Tyr Leu Lys Asn Pro Pro Glu Arg Met Ser Leu Arg

290 295 300Glu Leu Tyr Val Gly Gly Ser Ala Val Pro Pro Ile Val Ile Thr Met305 310 315 320Trp Glu Gln Arg Tyr Gly Val Asp Val Val His Val Trp Gly Met Thr

325 330 335Glu Thr SerThr Val Gly Thr Val Ser Arg Pro Pro Ser Gly Val Ser

340 345 350Gly Glu Ser Arg Trp Asn Tyr Arg Val Ser Gln Gly Arg Phe Pro Ala

355 360 365Ser Leu Gln Tyr Arg Ile Val Asn Asp Gly Gln Val Met Ala Ser Thr

370 375 380Asp Arg Asn Glu Gly Glu Ile Gln Val Arg Gly Pro Trp Val Thr Ala385 390 395 400Ser Tyr Phe His Pro Asp Val Glu Lys Glu Gly Gly Thr Ala Ser Thr

405 410 415Phe Arg Asp His Asp Val Glu Glu Glu Asn Asp Glu Leu Phe Thr Ala

420 425 430Asp Gly Trp Leu Arg Thr Gly Asp Val Gly Ser Val Thr Ser Asp Gly

435 440 445Phc Leu Thr Ile Gln Asp Arg Ala Arg Asp Val Ile Arg Ser Gly Gly

450 455 460Glu Trp Ile Tyr Ser Ala Gln Leu Glu Asn Leu Ile Val Ala Thr Glu465 470 475 480Glu Val Val Glu Cys Ala Val Ile Gly Phe Pro Asp Asp Lys Trp Val

485 490 495Glu Arg Pro Leu Ala Val Thr Met Leu Tyr Pro Gly Ile Glu Arg Thr

500 505 510Arg Glu Thr Ala Glu Arg Leu Arg Asp Gln Leu Arg Asp Arg Leu Pro

515 520 525Asn Trp Met Leu Pro Glu Tyr Trp Thr Phe Val Asp Glu Val Asp Lys

530 535 540Thr Ser Val Gly Lys Tyr Asp Lys Lys Asp Leu Arg Asn His Leu Arg545 550 555 560Asn Gly Asp Phe Glu Val Ile Lys Leu Lys Gly Pro Gly Glu Lys

565570575<210>65<211>1848<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1825)<223>FRXA01722<220><221>variant<222>479<223>Xaa ═ Thr<220><221>variant<222>574<223>Xaa ═ Glu<400>65ctcattcccc tcgctaaaag ctgcataaag tttcgacgtt ttcaaagttg attgcttgca 60ctgtcgttgc gtgtcgcatg ccccggctat tgttgattgc atg ctc agc acg atg 115

Met Leu Ser Thr Met

1 5cag gac gtc cca ctg tca tta acc aga atc ctc gag tac ggg tcc act 163Gln Asp Val Pro Leu Ser Leu Thr Arg Ile Leu Glu Tyr Gly Ser Thr

10 15 20gtt cac ggt gat act ttg atc acc acg tgg ggc ggt gcc gat ggc att 211Val His Gly Asp Thr Leu Ile Thr Thr Trp Gly Gly Ala Asp Gly Ile

25 30 35gaa caa gca cag caa act ttt agt gct gtg ggg gct aga gct gcg gct 259Glu Gln Ala Gln Gln Thr Phe Ser Ala Val Gly Ala Arg Ala Ala Ala

40 45 50ttg gct cat gcg ctg cat gat tct tta ggt att act ggg gat cag cga 307Leu Ala His Ala Leu His Asp Ser Leu Gly Ile Thr Gly Asp Gln Arg

55 60 65gtg gcg tcg atg ctc tat aac tgc gcg gaa cac atg gaa act atg ttt 355Val Ala Ser Met Leu Tyr Asn Cys Ala Glu His Met Glu Thr Met Phe 70 75 80 85gca gtc gca tgc atg ggt gcc gtg ttt aat ccg ctg aac aag cag ttg 403Ala Val Ala Cys Met Gly Ala Val Phe Asn Pro Leu Asn Lys Gln Leu

90 95 100atg aat gat cag att gtg ttcatt ctc aat cac tct gaa gct gaa gtg 451Met Asn Asp Gln Ile Val Phe Ile Leu Asn His Ser Glu Ala Glu Val

105 110 115gtt atc gct gat ccg cgc atg gct gaa caa ttg ggt gag atc tta aaa 499Val Ile Ala Asp Pro Arg Met Ala Glu Gln Leu Gly Glu Ile Leu Lys

120 125 130gaa aca cca aaa gtt cgt gcc gtg gtg ttt att gga ccg aat gat ttc 547Glu Thr Pro Lys Val Arg Ala Val Val Phe Ile Gly Pro Asn Asp Phe

135 140 145tct agc gcg gcg gcc cac atg ccg gag gga atg aag ctg tat tcc tat 595Ser Ser Ala Ala Ala His Met Pro Glu Gly Met Lys Leu Tyr Ser Tyr150 155 160 165gaa gcg ctc ctt gac ggc cgt tcc act gtt tac aac tgg ccc gag cag 643Glu Ala Leu Leu Asp Gly Arg Ser Thr Val Tyr Asn Trp Pro Glu Gln

170 175 180gat gaa cgc act gct gct gca att tgc tat tcc acc ggt aca tcg gga 691Asp Glu Arg Thr Ala Ala Ala Ile Cys Tyr Ser Thr Gly Thr Ser Gly

185 190 195ccg ccg aag ggt gtg gtg tat tcc cac cgc tcg ctt tat tta cag tcg 739Pro Pro Lys Gly Val Val Tyr Ser His Arg Ser Leu Tyr Leu Gln Ser

200 205 210ttg agc ttg cgc acc acg gat tcc ctc gca gtg gaa cac ggc gaa acg 787Leu Ser Leu Arg Thr Thr Asp Ser Leu Ala Val Glu His Gly Glu Thr

215 220 225ttc ctg tgc tgt gtg ccg att tac cac gtc ctc agc tgg ggc gtg ccg 835Phe Leu Cys Cys Val Pro Ile Tyr His Val Leu Ser Trp Gly Val Pro230 235 240 245atc gca gcg ttt atg tcc ggc act ccc ctg gtg ctt cct gga ccg gat 883Ile Ala Ala Phe Met Ser Gly Thr Pro Leu Val Leu Pro Gly Pro Asp

250 255 260ctt tct gcg ccg aca ttg gca aag atc att tcc acc acg ctg cct cgc 931Leu Ser Ala Pro Thr Leu Ala Lys Ile Ile Ser Thr Thr Leu Pro Arg

265 270 275gtg gcg cat ggc gtg cct act ctc tgg att cag ctg atg gtt cac tac 979Val Ala His Gly Val Pro Thr Leu Trp Ile Gln Leu Met Val His Tyr

280 285 290ctg aaa aat ccc cca gag cgt atg tct ctg cgt gag cta tac gtg ggc 1027Leu Lys Asn Pro Pro Glu Arg Met Ser Leu Arg Glu Leu Tyr Val Gly

295 300 305ggt tct gcg gtg cct cca atc gtg atc acc atg tgg gag cag cgc tat 1075Gly Ser Ala Val Pro Pro Ile Val Ile Thr Met Trp Glu Gln Arg Tyr310 315 320 325ggc gtg gat gtt gtc cac gtg tgg ggt atg acg gaa acc tcc acc gtg 1123Gly Val Asp Val Val His Val Trp Gly Met Thr Glu Thr Ser Thr Val

330 335 340ggt act gtg tct cgc cca cca tca ggt gtt tct ggt gaa agc cgg tgg 1171Gly Thr Val Ser Arg Pro Pro Ser Gly Val Ser Gly Glu Ser Arg Trp

345 350 355aat tat cga gtc tcc cag ggc cga ttc ccc gcc tcc ctg cag tac cgc 1219Asn Tyr Arg Val Ser Gln Gly Arg Phe Pro Ala Ser Leu Gln Tyr Arg

360 365 370att gtc aac gac ggc cag gtc atg gcg tcc acc gac cgc aac gag ggc 1267Ile Val Asn Asp Gly Gln Val Met Ala Ser Thr Asp Arg Asn Glu Gly

375 380 385gag att cag gtc cgc ggt ccg tgg gtg act gca agt tac ttc cac ccc 1315Glu Ile Gln Val Arg Gly Pro Trp Val Thr Ala Ser Tyr Phe His Pro390 395 400 405gat gtg gaa aaa gaa ggt ggc acc gcctca aca ttc cgc gac cat gac 1363Asp Val Glu Lys Glu Gly Gly Thr Ala Ser Thr Phe Arg Asp His Asp

410 415 420gtt gaa gag gaa aac gat gag ctc ttc acc gcc gac ggc tgg ctg cgc 1411Val Glu Glu Glu Asn Asp Glu Leu Phe Thr Ala Asp Gly Trp Leu Arg

425 430 435acc ggg gac gtt gga tct gtc acc agc gat gga ttc ctc acc atc caa 1459Thr Gly Asp Val Gly Ser Val Thr Ser Asp Gly Phe Leu Thr Ile Gln

440 445 450gac cgc gcc cgc gat gtc atc cgt tct ggc ggc gag tgg att tac tcc 1507Asp Arg Ala Arg Asp Val Ile Arg Ser Gly Gly Glu Trp Ile Tyr Ser

455 460 465gct cag ctg gaa aac ctc atc gtg gct acs gaa gag gtt gtc gaa tgc 1555Ala Gln Leu Glu Asn Leu Ile Val Ala Xaa Glu Glu Val Val Glu Cys470 475 480 485gcc gtc att ggc ttc ccc gat gac aag tgg gtg gaa cgt ccc ctc gca 1603Ala Val Ile Gly Phe Pro Asp Asp Lys Trp Val Glu Arg Pro Leu Ala

490 495 500gtc acc atg ctc tac ccc ggc att gaa cgc acc cgg gaa acc gcc gag 1651Val Thr Met Leu Tyr Pro Gly Ile Glu Arg Thr Arg Glu Thr Ala Glu

505 510 515cgc ctc cgc gat caa ctt cgc gac cgc cta ccc aac tgg atg ctg cca 1699Arg Leu Arg Asp Gln Leu Arg Asp Arg Leu Pro Asn Trp Met Leu Pro

520 525 530gaa tat tgg aca ttt gtt gat gag gtg gat aaa acc tcc gtc ggt aaa 1747Glu Tyr Trp Thr Phe Val Asp Glu Val Asp Lys Thr Ser Val Gly Lys

535 540 545tat gac aag aag gac ctc cgc aac cac ctg cgc aac ggc gat ttc gaa 1795Tyr Asp Lys Lys Asp Leu Arg Asn His Leu Arg Asn Gly Asp Phe Glu550555 560 565gta att aag ctt aaa ggg cca ggt gar aaa taacttccct atttattccg 1845Val Ile Lys Leu Lys Gly Pro Gly Xaa Lys

570575 gct1848<210>66<211>575<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>variant<222>479<223>Xaa ═ Thr<220><221>variant<222>574<223>Xaa ═ Glu<400>66Met Leu Ser Thr Met Gln Asp Val Pro Leu Ser Leu Thr Arg Ile Leu 151015 Glu Tyr Gly Ser Thr Val His Gly Asp Thr Leu Ile Thr Thr Trp Gly

20 25 30Gly Ala Asp Gly Ile Glu Gln Ala Gln Gln Thr Phe Ser Ala Val Gly

35 40 45Ala Arg Ala Ala Ala Leu Ala His Ala Leu His Asp Ser Leu Gly Ile

50 55 60Thr Gly Asp Gln Arg Val Ala Ser Met Leu Tyr Asn Cys Ala Glu His 65 70 75 80Met Glu Thr Met Phe Ala Val Ala Cys Met Gly Ala Val Phe Asn Pro

85 90 95Leu Asn Lys Gln Leu Met Asn Asp Gln Ile Val Phe Ile Leu Asn His

100 105 110Ser Glu Ala Glu Val Val Ile Ala Asp Pro Arg Met Ala Glu Gln Leu

115 120 125Gly Glu Ile Leu Lys Glu Thr Pro Lys Val Arg Ala Val Val Phe Ile

130 135 140Gly Pro Asn Asp Phe Ser Ser Ala Ala Ala His Met Pro Glu Gly Met145 150 155 160Lys Leu Tyr Ser Tyr Glu Ala Leu Leu Asp Gly Arg Ser Thr Val Tyr

165 170 175Asn Trp Pro Glu Gln Asp Glu Arg Thr Ala Ala Ala Ile Cys Tyr Ser

180 185 190Thr Gly Thr Ser Gly Pro Pro Lys Gly Val Val Tyr Ser His Arg Ser

195 200 205Leu Tyr Leu Gln Ser Leu Ser Leu Arg Thr Thr Asp Ser Leu Ala Val

210 215 220Glu His Gly Glu Thr Phe Leu Cys Cys Val Pro Ile Tyr His Val Leu225 230 235 240Ser Trp Gly Val Pro Ile Ala Ala Phe Met Ser Gly Thr Pro Leu Val

245 250 255Leu Pro Gly Pro Asp Leu Ser Ala Pro Thr Leu Ala Lys Ile Ile Ser

260 265 270Thr Thr Leu Pro Arg Val Ala His Gly Val Pro Thr Leu Trp Ile Gln

275 280 285Leu Met Val His Tyr Leu Lys Asn Pro Pro Glu Arg Met Ser Leu Arg

290 295 300Glu Leu Tyr Val Gly Gly Ser Ala Val Pro Pro Ile Val Ile Thr Met305 310 315 320Trp Glu Gln Arg Tyr Gly Val Asp Val Val His Val Trp Gly Met Thr

325 330 335Glu Thr Ser Thr Val Gly Thr Val Ser Arg Pro Pro Ser Gly Val Ser

340 345 350Gly Glu Ser Arg Trp Asn Tyr Arg Val Ser Gln Gly Arg Phe Pro Ala

355 360 365Ser Leu Gln Tyr Arg Ile Val Asn Asp Gly Gln Val Met Ala Ser Thr

370 375 380Asp Arg Asn Glu Gly Glu Ile Gln Val Arg Gly Pro Trp Val Thr Ala385 390 395 400Ser Tyr Phe His Pro Asp Val Glu Lys Glu Gly Gly Thr Ala Ser Thr

405 410 415Phe Arg Asp His Asp Val Glu Glu Glu Asn Asp Glu Leu Phe Thr Ala

420 425 430Asp Gly Trp Leu Arg Thr Gly Asp Val Gly Ser Val Thr Ser Asp Gly

435 440 445Phe Leu Thr Ile Gln Asp Arg Ala Arg Asp Val Ile Arg Ser Gly Gly

450 455 460Glu Trp Ile Tyr Ser Ala Gln Leu Glu Asn Leu Ile Val Ala Xaa Glu465 470 475 480Glu Val Val Glu Cys Ala Val Ile Gly Phe Pro Asp Asp Lys Trp Val

485 490 495Glu Arg Pro Leu Ala Val Thr Met Leu Tyr Pro Gly Ile Glu Arg Thr

500 505 510Arg Glu Thr Ala Glu Arg Leu Arg Asp Gln Leu Arg Asp Arg Leu Pro

515 520 525Asn Trp Met Leu Pro Glu Tyr Trp Thr Phe Val Asp Glu Val Asp Lys

530 535 540Thr Ser Val Gly Lys Tyr Asp Lys Lys Asp Leu Arg Asn His Leu Arg545 550 555 560Asn Gly Asp Phe Glu Val Ile Lys Leu Lys Gly Pro Gly Xaa Lys

565570575<210>67<211>1401<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1378)<223>RXA01644<400>67gtaggtagag gcttgtggtc actacttgtg gccacatttt aaaaaaatgc acaagaagag 60aaagcaaagc attatgagta acgccgtagc gcaggacctc atg acc atc gcc gac 115

Met Thr Ile Ala Asp

1 5atc gtc gag gcc acgacc act gca ccc atc cca ttc cac atc act gcc 163Ile Val Glu Ala Thr Thr Thr Ala Pro Ile Pro Phe His Ile Thr Ala

10 15 20ttc gat gga agc ttc act ggc cct gaa gat gct ccc tac cag ctg ttt 211Phe Asp Gly Ser Phe Thr Gly Pro Glu Asp Ala Pro Tyr Gln Leu Phe

25 30 35gtt gcc aac acg gat gca gta tcc tac atc gca aca gcg cca gga gat 259Val Ala Asn Thr Asp Ala Val Ser Tyr Ile Ala Thr Ala Pro Gly Asp

40 45 50ttg ggt ttg gca cgt gcc tac ctc atg gga gac ctc atc gtg gaa ggt 307Leu Gly Leu Ala Arg Ala Tyr Leu Met Gly Asp Leu Ile Val Glu Gly

55 60 65gag cat ccc ggc cat cct tat ggg atc ttt gat gcg ttg aag gag ttc 355Glu His Pro Gly His Pro Tyr Gly Ile Phe Asp Ala Leu Lys Glu Phe 70 75 80 85tac cgc tgc ttc aaa cgc cca gat gca tcc acc acc ttg cag atc atg 403Tyr Arg Cys Phe Lys Arg Pro Asp Ala Ser Thr Thr Leu Gln Ile Met

90 95 100tgg act ctg cgg aaa atg aat gcc tta aaa ttc cag gaa att cca cca 451Trp Thr Leu Arg Lys Met Asn Ala Leu Lys Phe Gln Glu Ile Pro Pro

105 110 115atg gaa caa gcc cct gca tgg cgt aaa gca ctg atc aac ggg cta gca 499Met Glu Gln Ala Pro Ala Trp Arg Lys Ala Leu Ile Asn Gly Leu Ala

120 125 130tcc agg cac tcg aaa tcc cgc gac aag aaa gcc att agc tac cac tac 547Ser Arg His Ser Lys Ser Arg Asp Lys Lys Ala Ile Ser Tyr His Tyr

135 140 145gac gtg ggc aat gag ttc tac tcc ctg ttt tta gat gat tcc atg acc 595Asp Val Gly Asn Glu Phe Tyr Ser Leu Phe LeuAsp Asp Ser Met Thr150 155 160 165tat acc tgc gcg tat tat cca acg cca gaa tca agt ttg gaa gaa gcc 643Tyr Thr Cys Ala Tyr Tyr Pro Thr Pro Glu Ser Ser Leu Glu Glu Ala

170 175 180caa gaa aac aaa tac cgc ctc atc ttt gaa aaa ctg cgt ctg aaa gaa 691Gln Glu Asn Lys Tyr Arg Leu Ile Phe Glu Lys Leu Arg Leu Lys Glu

185 190 195ggc gat cgc ctc cta gac gtg gga tgc ggt tgg gga ggc atg gtc cgc 739Gly Asp Arg Leu Leu Asp Val Gly Cys Gly Trp Gly Gly Met Val Arg

200 205 210tac gcc gcc aaa cac ggt gtg aaa gcc atc gga gtt acg ctg tct gaa 787Tyr Ala Ala Lys His Gly Val Lys Ala Ile Gly Val Thr Leu Ser Glu

215 220 225cag caa tat gag tgg ggt caa gca gag atc aaa cgc caa ggt ttg gaa 835Gln Gln Tyr Glu Trp Gly Gln Ala Glu Ile Lys Arg Gln Gly Leu Glu230 235 240 245gac ctc gcg gaa att cgc ttc atg gat tac cgc gat gtt cca gaa act 883Asp Leu Ala Glu Ile Arg Phe Met Asp Tyr Arg Asp Val Pro Glu Thr

250 255 260gga ttc gat gcg atc tca gca atc ggc atc att gaa cac atc ggt gtg 931Gly Phe Asp Ala Ile Ser Ala Ile Gly Ile Ile Glu His Ile Gly Val

265 270 275aac aac tat ccc gac tac ttt gaa ttg ctc agc agc aaa ctc aaa aca 979Asn Asn Tyr Pro Asp Tyr Phe Glu Leu Leu Ser Ser Lys Leu Lys Thr

280 285 290ggc gga ctg atg ctc aac cac agc atc acc tac cca gac aac cgc ccc 1027Gly Gly Leu Met Leu Asn His Ser Ile Thr Tyr Pro Asp Asn Arg Pro

295 300 305cgc cac gca ggt gca ttt att gat cgc tac att ttc ccc gac ggt gaa 1075Arg His Ala Gly Ala Phe Ile Asp Arg Tyr Ile Phe Pro Asp Gly Glu310 315 320 325ctc act ggc tct ggc acc ctg atc aag cac atg cag gac aac ggt ttc 1123Leu Thr Gly Ser Gly Thr Leu Ile Lys His Met Gln Asp Asn Gly Phe

330 335 340gaa gtg ctg cac gaa gaa aac ctc cgc ttt gat tac caa cgc acc ctg 1171Glu Val Leu His Glu Glu Asn Leu Arg Phe Asp Tyr Gln Arg Thr Leu

345 350 355cac gcg tgg tgc gaa aac ctc aaa gaa aat tgg gag gaa gca gtt gaa 1219His Ala Trp Cys Glu Asn Leu Lys Glu Asn Trp Glu Glu Ala Val Glu

360 365 370ctc gcc ggt gaa ccc act gca cga ctc ttt ggc ctg tac atg gca ggt 1267Leu Ala Gly Glu Pro Thr Ala Arg Leu Phe Gly Leu Tyr Met Ala Gly

375 380 385tcg gaa tgg gga ttt gcc cac aac atc gtc cag ctg cac caa gta ctg 1315Ser Glu Trp Gly Phe Ala His Asn Ile Val Gln Leu His Gln Val Leu390 395 400 405ggt gtg aaa ctc gat gag cag gga agt cgc gga gaa gtt cct gaa aga 1363Gly Val Lys Leu Asp Glu Gln Gly Ser Arg Gly Glu Val Pro Glu Arg

410 415 420atg tgg tgg act atc taaagaaaca atgtttcttt tta 1401Met Trp Trp Thr Ile

425<210>68<211>426<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>68Met Thr Ile Ala Asp Ile Val Glu Ala Thr Thr Thr Ala Pro Ile Pro 151015 Phe His Ile Thr Ala Phe Asp Gly Ser Phe Thr Gly Pro Glu Asp Ala

20 25 30Pro Tyr Gln Leu Phe Val Ala Asn Thr Asp Ala Val Ser Tyr Ile Ala

35 40 45Thr Ala Pro Gly Asp Leu Gly Leu Ala Arg Ala Tyr Leu Met Gly Asp

50 55 60Leu Ile Val Glu Gly Glu His Pro Gly His Pro Tyr Gly Ile Phe Asp 65 70 75 80Ala Leu Lys Glu Phe Tyr Arg Cys Phe Lys Arg Pro Asp Ala Ser Thr

85 90 95Thr Leu Gln Ile Met Trp Thr Leu Arg Lys Met Asn Ala Leu Lys Phe

100 105 110Gln Glu Ile Pro Pro Met Glu Gln Ala Pro Ala Trp Arg Lys Ala Leu

115 120 125Ile Asn Gly Leu Ala Ser Arg His Ser Lys Ser Arg Asp Lys Lys Ala

130 135 140Ile Ser Tyr His Tyr Asp Val Gly Asn Glu Phe Tyr Ser Leu Phe Leu145 150 155 160Asp Asp Ser Met Thr Tyr Thr Cys Ala Tyr Tyr Pro Thr Pro Glu Ser

165 170 175Ser Leu Glu Glu Ala Gln Glu Asn Lys Tyr Arg Leu Ile Phe Glu Lys

180 185 190Leu Arg Leu Lys Glu Gly Asp Arg Leu Leu Asp Val Gly Cys Gly Trp

195 200 205Gly Gly Met Val Arg Tyr Ala Ala Lys His Gly Val Lys Ala Ile Gly

210 215 220Val Thr Leu Ser Glu Gln Gln Tyr Glu Trp Gly Gln Ala Glu Ile Lys225 230 235 240Arg Gln Gly Leu Glu Asp Leu Ala Glu Ile Arg Phe Met Asp Tyr Arg

245 250 255Asp Val Pro Glu Thr Gly Phe Asp Ala Ile Ser Ala Ile Gly Ile Ile

260265 270Glu His Ile Gly Val Asn Asn Tyr Pro Asp Tyr Phe Glu Leu Leu Ser

275 280 285Ser Lys Leu Lys Thr Gly Gly Leu Met Leu Asn His Ser Ile Thr Tyr

290 295 300Pro Asp Asn Arg Pro Arg His Ala Gly Ala Phe Ile Asp Arg Tyr Ile305 310 315 320Phe Pro Asp Gly Glu Leu Thr Gly Ser Gly Thr Leu Ile Lys His Met

325 330 335Gln Asp Asn Gly Phe Glu Val Leu His Glu Glu Asn Leu Arg Phe Asp

340 345 350Tyr Gln Arg Thr Leu His Ala Trp Cys Glu Asn Leu Lys Glu Asn Trp

355 360 365Glu Glu Ala Val Glu Leu Ala Gly Glu Pro Thr Ala Arg Leu Phe Gly

370 375 380Leu Tyr Met Ala Gly Ser Glu Trp Gly Phe Ala His Asn Ile Val Gln385 390 395 400Leu His Gln Val Leu Gly Val Lys Leu Asp Glu Gln Gly Ser Arg Gly

405 410 415Glu Val Pro Glu Arg Met Trp Trp Thr Ile

420425<210>69<211>1437<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1414)<223>RXA02029<400>69cgcacgtaca ctacttttag cagttaaccc gccgaacttt cttgattaag tattcattga 60gcgttcttgg cataaatccc actggaggtg catcaaacgt atg gca gag gca cgt 115

Met Ala Glu Ala Arg

1 5ttg cgc cat ctt gaa ccc att gat gtg gaa gag tgg cct ggg gtg gcg 163Leu Arg His Leu Glu Pro Ile Asp Val Glu Glu Trp Pro Gly Val Ala

10 15 20tca gtg ccc aac cta gcg ttt gct ggt gca cgc gca cgg caa gca gaa 211Ser Val Pro Asn Leu Ala Phe Ala Gly Ala Arg Ala Arg Gln Ala Glu

25 30 35tat cga ttt gcc aag gcc tgc agc aac gca ggt tta gtt ctg cta gga 259Tyr Arg Phe Ala Lys Ala Cys Ser Asn Ala Gly Leu Val Leu Leu Gly

40 45 50aat gac ccg gat ctc att att gat cat gag gaa tta ttc tca cgt ttg 307Asn Asp Pro Asp Leu Ile Ile Asp His Glu Glu Leu Phe Ser Arg Leu

55 60 65gcc gca tcg ggc tgg ctg ggg ctc gct gag agc tac atg gca ggc gag 355Ala Ala Ser Gly Trp Leu Gly Leu Ala Glu Ser Tyr Met Ala Gly Glu 70 75 80 85tgg cgc agc gag agg ctt gcc gac gtc ttg acc gct ttg ttg gga act 403Trp Arg Ser Glu Arg Leu Ala Asp Val Leu Thr Ala Leu Leu Gly Thr

90 95 100ggg ttt aaa ccc cgc ggc aaa cta tct gga tcg ttc acc ctg cca ggg 451Gly Phe Lys Pro Arg Gly Lys Leu Ser Gly Ser Phe Thr Leu Pro Gly

105 110 115caa gct gtg gat gcc gga ggc gca cta ccc aat gaa ctc att cgt tta 499Gln Ala Val Asp Ala Gly Gly Ala Leu Pro Asn Glu Leu Ile Arg Leu

120 125 130agt tca ggt gat ggc atg agc gca ttt ggt gga gtt ttt gcc tcc ggt 547Ser Ser Gly Asp Gly Met Ser Ala Phe Gly Gly Val Phe Ala Ser Gly

135 140 145gtt cca acc act tta cgt acc gca gtg aaa agc cat gtg ccg gga gct 595Val Pro Thr Thr Leu Arg Thr Ala Val Lys Ser His Val Pro Gly Ala150 155 160 165ggt cgc aat agggag ccc gca tct cac ttt gtg gat atc acc aag atc 643Gly Arg Asn Arg Glu Pro Ala Ser His Phe Val Asp Ile Thr Lys Ile

170 175 180tcg gag cct gtg gcc gtg gag cgt gaa gac ctc ggc gag gct cag cgc 691Ser Glu Pro Val Ala Val Glu Arg Glu Asp Leu Gly Glu Ala Gln Arg

185 190 195cga gca gcg tcc ttt ttg ctt gac ggc gcc aaa gtt aaa gcc gga agc 739Arg Ala Ala Ser Phe Leu Leu Asp Gly Ala Lys Val Lys Ala Gly Ser

200 205 210cat gtg ttg gag ttt ccc agc agt ggt gga gct tta gct att ttg gct 787His Val Leu Glu Phe Pro Ser Ser Gly Gly Ala Leu Ala Ile Leu Ala

215 220 225gct cga cgc cag gga act gtt gac gct tta acg gct gat ccc gcg caa 835Ala Arg Arg Gln Gly Thr Val Asp Ala Leu Thr Ala Asp Pro Ala Gln230 235 240 245gtt tca agc ctg gag gag acg ttt gtg ctc gcc ggt gtg gag gag gat 883Val Ser Ser Leu Glu Glu Thr Phe Val Leu Ala Gly Val Glu Glu Asp

250 255 260att cac atc gag gtc att ccc cag gcg att ccc tcg cca cgc gaa tgg 931Ile His Ile Glu Val Ile Pro Gln Ala Ile Pro Ser Pro Arg Glu Trp

265 270 275ggt ggc gcc tac gat tcg ata gtc gcc atg gag aag cta gaa gtg gtg 979Gly Gly Ala Tyr Asp Ser Ile Val Ala Met Glu Lys Leu Glu Val Val

280 285 290ggc aag cac ggt tcc aag cgg ttt att aaa gct atc gac aga atg ctc 1027Gly Lys His Gly Ser Lys Arg Phe Ile Lys Ala Ile Asp Arg Met Leu

295 300 305acc acc ggc ggc aac gta gcc atg caa tcc ttg gta gct act gac caa 1075Thr Thr Gly Gly Asn Val Ala Met Gln Ser Leu Val Ala Thr Asp Gln310 315 320 325tgg agt cct gtg tgt tct gaa gcg att tct ttg ctc aag gcc tat att 1123Trp Ser Pro Val Cys Ser Glu Ala Ile Ser Leu Leu Lys Ala Tyr Ile

330 335 340tgg cct gcg ctg cat tac cca act gtt gat gaa gtt cat cag ctt gtt 1171Trp Pro Ala Leu His Tyr Pro Thr Val Asp Glu Val His Gln Leu Val

345 350 355gat agg gat tct tct ctg cgc gtg gtg aag gaa aca cac ttt gcg ggc 1219Asp Arg Asp Ser Ser Leu Arg Val Val Lys Glu Thr His Phe Ala Gly

360 365 370cat tac cta aaa agc gtg cag ttg caa cgt gaa gtg ttt gaa ggc cag 1267His Tyr Leu Lys Ser Val Gln Leu Gln Arg Glu Val Phe Glu Gly Gln

375 380 385ata cgc gaa gcg gcg gca gat ggc ttt gat gcc gtc tac cgc cgc atg 1315Ile Arg Glu Ala Ala Ala Asp Gly Phe Asp Ala Val Tyr Arg Arg Met390 395 400 405tgg gtg tat cac tac gcg ctt att gaa gcc ctg tta cgc ctg gga tgt 1363Trp Val Tyr His Tyr Ala Leu Ile Glu Ala Leu Leu Arg Leu Gly Cys

410 415 420ctc aat gca gtg caa ttt gcg ttg acg aca aga aac aga agg ggg cgt 1411Leu Asn Ala Val Gln Phe Ala Leu Thr Thr Arg Asn Arg Arg Gly Arg

425430435 cga taagcaaaaa tcttttagac ctc 1437Arg<210>70<211>438<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>70Met Ala Glu Ala Arg Leu Arg His Leu Glu Pro Ile Asp Val Glu Glu 151015 Trp Pro Gly Val Ala Ser Val Pro Asn Leu Ala Phe Ala Gly Ala Arg

20 25 30Ala Arg Gln Ala Glu Tyr Arg Phe Ala Lys Ala Cys Ser Asn Ala Gly

35 40 45Leu Val Leu Leu Gly Asn Asp Pro Asp Leu Ile Ile Asp His Glu Glu

50 55 60Leu Phe Ser Arg Leu Ala Ala Ser Gly Trp Leu Gly Leu Ala Glu Ser 65 70 75 80Tyr Met Ala Gly Glu Trp Arg Ser Glu Arg Leu Ala Asp Val Leu Thr

85 90 95Ala Leu Leu Gly Thr Gly Phe Lys Pro Arg Gly Lys Leu Ser Gly Ser

100 105 110Phe Thr Leu Pro Gly Gln Ala Val Asp Ala Gly Gly Ala Leu Pro Asn

115 120 125Glu Leu Ile Arg Leu Ser Ser Gly Asp Gly Met Ser Ala Phe Gly Gly

130 135 140Val Phe Ala Ser Gly Val Pro Thr Thr Leu Arg Thr Ala Val Lys Ser145 150 155 160His Val Pro Gly Ala Gly Arg Asn Arg Glu Pro Ala Ser His Phe Val

165 170 175Asp Ile Thr Lys Ile Ser Glu Pro Val Ala Val Glu Arg Glu Asp Leu

180 185 190Gly Glu Ala Gln Arg Arg Ala Ala Ser Phe Leu Leu Asp Gly Ala Lys

195 200 205Val Lys Ala Gly Ser His Val Leu Glu Phe Pro Ser Ser Gly Gly Ala

210 215 220Leu Ala Ile Leu Ala Ala Arg Arg Gln Gly Thr Val Asp Ala Leu Thr225 230 235 240Ala Asp Pro Ala Gln Val Ser Ser Leu Glu Glu Thr Phe Val Leu Ala

245 250 255Gly Val Glu Glu Asp Ile His Ile Glu Val Ile Pro Gln Ala Ile Pro

260 265 270Ser Pro Arg Glu Trp Gly Gly Ala Tyr Asp Ser Ile Val Ala Met Glu

275 280 285Lys Leu Glu Val Val Gly Lys His Gly Ser Lys Arg Phe Ile Lys Ala

290 295 300Ile Asp Arg Met Leu Thr Thr Gly Gly Asn Val Ala Met Gln Ser Leu305 310 315 320Val Ala Thr Asp Gln Trp Ser Pro Val Cys Ser Glu Ala Ile Ser Leu

325 330 335Leu Lys Ala Tyr Ile Trp Pro Ala Leu His Tyr Pro Thr Val Asp Glu

340 345 350Val His Gln Leu Val Asp Arg Asp Ser Ser Leu Arg Val Val Lys Glu

355 360 365Thr His Phe Ala Gly His Tyr Leu Lys Ser Val Gln Leu Gln Arg Glu

370 375 380Val Phe Glu Gly Gln Ile Arg Glu Ala Ala Ala Asp Gly Phe Asp Ala385 390 395 400Val Tyr Arg Arg Met Trp Val Tyr His Tyr Ala Leu Ile Glu Ala Leu

405 410 415Leu Arg Leu Gly Cys Leu Asn Ala Val Gln Phe Ala Leu Thr Thr Arg

420 425 430Asn Arg Arg Gly Arg Arg

435<210>71<211>1140<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1117)<223>RXA01801<400>71tttggattcc tttccgatta tgtcttgatc gcccattctg tcacatccgg gttgtctaaa 60cacccgcgaa gatttcctgt gatgtgccac actggttctc atg tct aac gta gtg 115

Met Ser Asn Val Val

1 5aac act ttt gtc cag aat tcc acc ggt atg gtg gag ctt aat cgt ccc 163Asn Thr Phe Val Gln Asn Ser Thr Gly Met Val Glu Leu Asn Arg Pro

10 15 20aaa gcg ctc aat tct ctt aat cag gaa atg atc gat ctc gtt cag gaa 211Lys Ala Leu Asn Ser Leu Asn Gln Glu Met Ile Asp Leu Val Gln Glu

25 30 35gct cta acc act tgg gct gat gat gat cag gtg cag cag gtt ctc att 259Ala Leu Thr Thr Trp Ala Asp Asp Asp Gln Val Gln Gln Val Leu Ile

40 45 50tac tca tcc tcg gag cgt gca ttt tgt gcc ggc ggt gat gtg cgc gcg 307Tyr Ser Ser Ser Glu Arg Ala Phe Cys Ala Gly Gly Asp Val Arg Ala

55 60 65gtc cgt gag agc gtg ttg gag ggc gat gtt gcg gcc ggc gat aag tat 355Val Arg Glu Ser Val Leu Glu Gly Asp Val Ala Ala Gly Asp Lys Tyr 70 75 80 85ttc atc gat gag ttc gcg atg aac aac acg ttg gga acc tat ccg aag 403Phe Ile Asp Glu Phe Ala Met Asn Asn Thr Leu Gly Thr Tyr Pro Lys

90 95 100ccg gtc att tct gtg atc aac ggc gtc gcg atg ggt ggc gga atg gga 451Pro Val Ile Ser Val Ile Asn Gly Val Ala Met Gly Gly Gly Met Gly

105 110 115att tcc atg cat gga tcg cac cgg atc gtc acg gaa aaa gcg ttc gcg 499Ile Ser Met His Gly Ser His Arg Ile Val Thr Glu Lys Ala Phe Ala

120 125 130tcg atg cct gag atg gcg atc ggc tat gtt ccc gat gtg ggc ttt act 547Ser Met Pro Glu Met Ala Ile Gly Tyr Val Pro Asp Val Gly Phe Thr

135 140 145tat ttc ggt cag cgt gca tcg tcg ctg gcc atc gcc acattt ttg gcg 595Tyr Phe Gly Gln Arg Ala Ser Ser Leu Ala Ile Ala Thr Phe Leu Ala150 155 160 165gtg acc ggg tgg cgc atg agc cct gcc gat atg ctg tgg gct ggc gtc 643Val Thr Gly Trp Arg Met Ser Pro Ala Asp Met Leu Trp Ala Gly Val

170 175 180gca acg cat ttt gtt gag gat gcg cag ggg ttc att gat gcg gtc ttg 691Ala Thr His Phe Val Glu Asp Ala Gln Gly Phe Ile Asp Ala Val Leu

185 190 195aac gag tcg ctt gat ggc gcg ctg gag aaa ttc tcc acg caa cct acg 739Asn Glu Ser Leu Asp Gly Ala Leu Glu Lys Phe Ser Thr Gln Pro Thr

200 205 210ggc agc agc gag ctg gcc ggc gtc gcc agc cag att gag gag acc ttt 787Gly Ser Ser Glu Leu Ala Gly Val Ala Ser Gln Ile Glu Glu Thr Phe

215 220 225ggg cac agc tct tgg gcg ctt atc gac gcc tcc ctc cgg tct cac ccc 835Gly His Ser Ser Trp Ala Leu Ile Asp Ala Ser Leu Arg Ser His Pro230 235 240 245gat gct gaa ttt gtt gcc aag gtg gat ggg ctg atg gcg tcg gca gca 883Asp Ala Glu Phe Val Ala Lys Val Asp Gly Leu Met Ala Ser Ala Ala

250 255 260ccg gca tcg gtg gtg gct acc gtg aag ctg atg cat caa aac agt gag 931Pro Ala Ser Val Val Ala Thr Val Lys Leu Met His Gln Asn Ser Glu

265 270 275gcg acc act ctg cgt gaa ggc ttg gac aat gaa ttg gcg atg tct ctt 979Ala Thr Thr Leu Arg Glu Gly Leu Asp Asn Glu Leu Ala Met Ser Leu

280 285 290tat atg atc cgc cag cct gat ttt gct gaa ggt gtg cgt gca gtg ttg 1027Tyr Met Ile Arg Gln Pro Asp Phe Ala Glu Gly Val Arg Ala Val Leu

295 300 305gtt gat aaa gac cgc aat gca gcc ttc tcc cca gcc aac tac gaa gat 1075Val Asp Lys Asp Arg Asn Ala Ala Phe Ser Pro Ala Asn Tyr Glu Asp310 315 320 325gtt gat gag tca cat ttt gtg acc ttg ttc cag cgc agt tca 1117Val Asp Glu Ser His Phe Val Thr Leu Phe Gln Arg Ser Ser

330335 taaaaccgcc aaacttttga tag 1140<210>72<211>339<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>72Met Ser Asn Val Val Asn Thr Phe Val Gln Asn Ser Thr Gly Met Val 151015 Glu Leu Asn Arg Pro Lys Ala Leu Asn Ser Leu Asn Gln Glu Met Ile

20 25 30Asp Leu Val Gln Glu Ala Leu Thr Thr Trp Ala Asp Asp Asp Gln Val

35 40 45Gln Gln Val Leu Ile Tyr Ser Ser Ser Glu Arg Ala Phe Cys Ala Gly

50 55 60Gly Asp Val Arg Ala Val Arg Glu Ser Val Leu Glu Gly Asp Val Ala 65 70 75 80Ala Gly Asp Lys Tyr Phe Ile Asp Glu Phe Ala Met Asn Asn Thr Leu

85 90 95Gly Thr Tyr Pro Lys Pro Val Ile Ser Val Ile Asn Gly Val Ala Met

100 105 110Gly Gly Gly Met Gly Ile Ser Met His Gly Ser His Arg Ile Val Thr

115 120 125Glu Lys Ala Phe Ala Ser Met Pro Glu Met Ala Ile Gly Tyr Val Pro

130 135 140Asp Val Gly Phe Thr Tyr Phe Gly Gln Arg Ala Ser Ser Leu Ala Ile145 150 155 160Ala Thr Phe Leu Ala Val Thr Gly Trp Arg Met Ser Pro Ala Asp Met

165 170 175Leu Trp Ala Gly Val Ala Thr His Phe Val Glu Asp Ala Gln Gly Phe

180 185 190Ile Asp Ala Val Leu Asn Glu Ser Leu Asp Gly Ala Leu Glu Lys Phe

195 200 205Ser Thr Gln Pro Thr Gly Ser Ser Glu Leu Ala Gly Val Ala Ser Gln

210 215 220Ile Glu Glu Thr Phe Gly His Ser Ser Trp Ala Leu Ile Asp Ala Ser225 230 235 240Leu Arg Ser His Pro Asp Ala Glu Phe Val Ala Lys Val Asp Gly Leu

245 250 255Met Ala Ser Ala Ala Pro Ala Ser Val Val Ala Thr Val Lys Leu Met

260 265 270His Gln Asn Ser Glu Ala Thr Thr Leu Arg Glu Gly Leu Asp Asn Glu

275 280 285Leu Ala Met Ser Leu Tyr Met Ile Arg Gln Pro Asp Phe Ala Glu Gly

290 295 300Val Arg Ala Val Leu Val Asp Lys Asp Arg Asn Ala Ala Phe Ser Pro305 310 315 320Ala Asn Tyr Glu Asp Val Asp Glu Ser His Phe Val Thr Leu Phe Gln

325330335 Arg Ser Ser<210>73<211>1086<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1063)<223>RXN02512<400>73gctggaaagt ccccattggc taaggaattt accaaggcac cagcaggtgc gaaggcagat 60tacagcaaca ccaaataaaa attagccgag ggagcatcgc atg aag ccg aag gat 115

Met Lys Pro Lys Asp

1 5ttc tgc aca gcg gaa aat tgg gcg gag aat tta agc gca ctg ggc tat 163Phe Cys Thr Ala Glu Asn Trp Ala Glu Asn Leu Ser Ala Leu Gly Tyr

10 15 20cta gct ggt tgg cgt ttt gtc cgg atg ctc cct ttg cct att gct cgc 211Leu Ala Gly Trp Arg Phe Val Arg Met Leu Pro Leu Pro Ile Ala Arg

25 30 35cgg gtg ttt gac ctt ggg gcg gat ctg gcg tcg aaa agc gga aaa ggc 259Arg Val Phe Asp Leu Gly Ala Asp Leu Ala Ser Lys Ser Gly Lys Gly

40 45 50atg ggg cag cta cgc gct aat ctg gcg cgg gtg gtc ggt gcg gaa aac 307Met Gly Gln Leu Arg Ala Asn Leu Ala Arg Val Val Gly Ala Glu Asn

55 60 65gtt acg cag gcg ctg gtg aag caa gca acg cgc agc tat gcg cgg tat 355Val Thr Gln Ala Leu Val Lys Gln Ala Thr Arg Ser Tyr Ala Arg Tyr 70 75 80 85tgg ctg gaa gcg ttc cgg cta ccg gcg atc gcg cga gat cct gag ctg 403Trp Leu Glu Ala Phe Arg Leu Pro Ala Ile Ala Arg Asp Pro Glu Leu

90 95 100ctt gcg cgg ttg cgt aag gga act gtt ggc cta gat ttg ttg gat gaa 451Leu Ala Arg Leu Arg Lys Gly Thr Val Gly Leu Asp Leu Leu Asp Glu

105 110 115tct ttg gct gcc ggc aag ggc gta gtt ttg acg ctc cca cac agc ggc 499Ser Leu Ala Ala Gly Lys Gly Val Val Leu Thr Leu Pro His Ser Gly

120 125 130aac tgg gat atg gct ggc gct ttt ctg att agc cat cat ggg caa ttc 547Asn Trp Asp Met Ala Gly Ala Phe Leu Ile Ser His His Gly Gln Phe

135 140 145acc acc gtt gca gaa agg gtc aag ccg gaa cgc ttg ttt gaa gcg ttc 595Thr Thr Val Ala Glu Arg Val Lys Pro Glu Arg Leu Phe Glu Ala Phe150 155160 165gtg gag ttt cga gaa agc ctt gga ttt gag gtg ctg cct ctc acc ggt 643Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val Leu Pro Leu Thr Gly

170 175 180ggc gag cgt ccg ccg ttt gaa aag ctg aaa gag cgc ctg aca tct gga 691Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu Arg Leu Thr Ser Gly

185 190 195ggt atc gtg tgc ctt ctt ggg gag cgt gac ctg cgg cat tcc ggc gtg 739Gly Ile Val Cys Leu Leu Gly Glu Arg Asp Leu Arg His Ser Gly Val

200 205 210gag acc act ttt ttt ggt gag aag acc tcc atg cca gca gga cct gcg 787Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met Pro Ala Gly Pro Ala

215 220 225cag ctg gcc att gaa aca ggt gcg gcg ctg cac gtg gtg cat cca tgg 835Gln Leu Ala Ile Glu Thr Gly Ala Ala Leu His Val Val His Pro Trp230 235 240 245ttc gat gac gac ggc tgg ggt ctc agc gta tcc gat gcc gtg acc gtg 883Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser Asp Ala Val Thr Val

250 255 260gat aat tta tcc gac acg gtg cag cgg atc gca cat ctt ttt atg gca 931Asp Asn Leu Ser Asp Thr Val Gln Arg Ile Ala His Leu Phe Met Ala

265 270 275aat att acg gcg cac ccc gct gat tgg cat atg ctc caa ccc ctg tgg 979Asn Ile Thr Ala His Pro Ala Asp Trp His Met Leu Gln Pro Leu Trp

280 285 290ttt ggt gat ttg gat ccg gag cgt ctc aag cgc tct agg gag cag aca 1027Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg Ser Arg Glu Gln Thr

295300305 aat gtt cac aaa ccg gtg gca tta cag gag gac aat taggtgcgaa 1073Asn Val His Lys Pro Val Ala Leu Gln Glu Asp Asn 310315320 ttggaatggt ctg 1086<210>74<211>321<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>74Met Lys Pro Lys Asp Phe Cys Thr Ala Glu Asn Trp Ala Glu Asn Leu 151015 Ser Ala Leu Gly Tyr Leu Ala Gly Trp Arg Phe Val Arg Met Leu Pro

20 25 30Leu Pro Ile Ala Arg Arg Val Phe Asp Leu Gly Ala Asp Leu Ala Ser

35 40 45Lys Ser Gly Lys Gly Met Gly Gln L8u Arg Ala Asn Leu Ala Arg Val

50 55 60Val Gly Ala Glu Asn Val Thr Gln Ala Leu Val Lys Gln Ala Thr Arg 65 70 75 80Ser Tyr Ala Arg Tyr Trp Leu Glu Ala Phe Arg Leu Pro Ala Ile Ala

85 90 95Arg Asp Pro Glu Leu Leu Ala Arg Leu Arg Lys Gly Thr Val Gly Leu

100 105 110Asp Leu Leu Asp Glu Ser Leu Ala Ala Gly Lys Gly Val Val Leu Thr

115 120 125Leu Pro His Ser Gly Asn Trp Asp Met Ala Gly Ala Phe Leu Ile Ser

130 135 140His His Gly Gln Phe Thr Thr Val Ala Glu Arg Val Lys Pro Glu Arg145 150 155 160Leu Phe Glu Ala Phe Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val

165 170 175Leu Pro Leu Thr Gly Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu

180 185 190Arg Leu Thr Ser Gly Gly Ile Val Cys Leu Leu Gly Glu Arg Asp Leu

195 200 205Arg His Ser Gly Val Glu Thr ThrPhe Phe Gly Glu Lys Thr Ser Met

210 215 220Pro Ala Gly Pro Ala Gln Leu Ala Ile Glu Thr Gly Ala Ala Leu His225 230 235 240Val Val His Pro Trp Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser

245 250 255Asp Ala Val Thr Val Asp Asn Leu Ser Asp Thr Val Gln Arg Ile Ala

260 265 270His Leu Phe Met Ala Asn Ile Thr Ala His Pro Ala Asp Trp His Met

275 280 285Leu Gln Pro Leu Trp Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg

290295300 Ser Arg Glu Gln Thr Asn Val His Lys Pro Val Ala Leu Gln Glu Asp 305310315320 Asn<210>75<211>1057<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1057)<223>FRXA02512<400>75gctggaaagt ccccattggc taaggaattt accaaggcac cagcaggtgc gaaggcagat 60tacagcaaca ccaaataaaa attagccgag ggagcatcgc atg aag ccg aag gat 115

Met Lys Pro Lys Asp

1 5ttc tgc aca gcg gaa aat tgg gcg gag aat tta agc gca ctg ggc tat 163Phe Cys Thr Ala Glu Asn Trp Ala Glu Asn Leu Ser Ala Leu Gly Tyr

10 15 20cta gct ggt tgg cgt ttt gtc cgg atg ctc cct ttg cct att gct cgc 211Leu Ala Gly Trp Arg Phe Val Arg Met Leu Pro Leu Pro Ile Ala Arg

25 30 35cgg gtg ttt gac ctt ggg gcg gat ctg gcg tcg aaa agc gga aaa ggc 259Arg Val Phe Asp Leu Gly Ala Asp Leu Ala Ser Lys Ser Gly Lys Gly

4045 50atg ggg cag cta cgc gct aat ctg gcg cgg gtg gtc ggt gcg gaa aac 307Met Gly Gln Leu Arg Ala Asn Leu Ala Arg Val Val Gly Ala Glu Asn

55 60 65gtt acg cag gcg ctg gtg aag caa gca acg cgc agc tat gcg cgg tat 355Val Thr Gln Ala Leu Val Lys Gln Ala Thr Arg Ser Tyr Ala Arg Tyr 70 75 80 85tgg ctg gaa gcg ttc cgg cta ccg gcg atc gcg cga gat cct gag ctg 403Trp Leu Glu Ala Phe Arg Leu Pro Ala Ile Ala Arg Asp Pro Glu Leu

90 95 100ctt gcg cgg ttg cgt aag gga act gtt ggc cta gat ttg ttg gat gaa 451Leu Ala Arg Leu Arg Lys Gly Thr Val Gly Leu Asp Leu Leu Asp Glu

105 110 115tct ttg gct gcc ggc aag ggc gta gtt ttg acg ctc cca cac agc ggc 499Ser Leu Ala Ala Gly Lys Gly Val Val Leu Thr Leu Pro His Ser Gly

120 125 130aac tgg gat atg gct ggc gct ttt ctg att agc cat cat ggg caa ttc 547Asn Trp Asp Met Ala Gly Ala Phe Leu Ile Ser His His Gly Gln Phe

135 140 145acc acc gtt gca gaa agg gtc aag ccg gaa cgc ttg ttt gaa gcg ttc 595Thr Thr Val Ala Glu Arg Val Lys Pro Glu Arg Leu Phe Glu Ala Phe150 155 160 165gtg gag ttt cga gaa agc ctt gga ttt gag gtg ctg cct ctc acc ggt 643Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val Leu Pro Leu Thr Gly

170 175 180ggc gag cgt ccg ccg ttt gaa aag ctg aaa gag cgc ctg aca tct gga 691Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu Arg Leu Thr Ser Gly

185 190 195ggt atc gtg tgc ctt ctt ggg gag cgt gac ctg cgg cat tcc ggc gtg 739Gly Ile Val Cys Leu Leu Gly Glu Arg Asp Leu Arg His Ser Gly Val

200 205 210gag acc act ttt ttt ggt gag aag acc tcc atg cca gca gga cct gcg 787Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met Pro Ala Gly Pro Ala

215 220 225cag ctg gcc att gaa aca ggt gcg gcg ctg cac gtg gtg cat cca tgg 835Gln Leu Ala Ile Glu Thr Gly Ala Ala Leu His Val Val His Pro Trp230 235 240 245ttc gat gac gac ggc tgg ggt ctc agc gta tcc gat gcc gtg acc gtg 883Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser Asp Ala Val Thr Val

250 255 260gat aat tta tcc gac acg gtg cag cgg atc gca cat ctt ttt atg gca 931Asp Asn Leu Ser Asp Thr Val Gln Arg Ile Ala His Leu Phe Met Ala

265 270 275aat att acg gcg cac ccc gct gat tgg cat atg ctc caa ccc ctg tgg 979Asn Ile Thr Ala His Pro Ala Asp Trp His Met Leu Gln Pro Leu Trp

280 285 290ttt ggt gat ttg gat ccg gag cgt ctc aag cgc tct agg gag cag aca 1027Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg Ser Arg Glu Gln Thr

295300305 aat gtt cac aaa ccg gtg gca tta cag gag 1057Asn Val His Lys Pro Val Ala Leu Gln Glu 310315<210>76<211>319<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>76Met Lys Pro Lys Asp Phe Cys Thr Ala Glu Asn Trp Ala Glu Asn Leu 151015 Ser Ala Leu Gly Tyr Leu Ala Gly Trp Arg Phe Val Arg Met Leu Pro

20 25 30Leu Pro Ile Ala Arg Arg Val Phe Asp Leu Gly Ala Asp Leu Ala Ser

35 40 45Lys Ser Gly Lys Gly Met Gly Gln Leu Arg Ala Asn Leu Ala Arg Val

50 55 60Val Gly Ala Glu Asn Val Thr Gln Ala Leu Val Lys Gln Ala Thr Arg65 70 75 80Ser Tyr Ala Arg Tyr Trp Leu Glu Ala Phe Arg Leu Pro Ala Ile Ala

85 90 95Arg Asp Pro Glu Leu Leu Ala Arg Leu Arg Lys Gly Thr Val Gly Leu

100 105 110Asp Leu Leu Asp Glu Ser Leu Ala Ala Gly Lys Gly Val Val Leu Thr

115 120 125Leu Pro His Ser Gly Asn Trp Asp Met Ala Gly Ala Phe Leu Ile Ser

130 135 140His His Gly Gln Phe Thr Thr Val Ala Glu Arg Val Lys Pro Glu Arg145 150 155 160Leu Phe Glu Ala Phe Val Glu Phe Arg Glu Ser Leu Gly Phe Glu Val

165 170 175Leu Pro Leu Thr Gly Gly Glu Arg Pro Pro Phe Glu Lys Leu Lys Glu

180 185 190Arg Leu Thr Ser Gly Gly Ile Val Cys Leu Leu Gly Glu Arg Asp Leu

195 200 205Arg His Ser Gly Val Glu Thr Thr Phe Phe Gly Glu Lys Thr Ser Met

210 215 220Pro Ala Gly Pro Ala Gln Leu Ala Ile Glu Thr Gly Ala Ala Leu His225 230 235 240Val Val His Pro Trp Phe Asp Asp Asp Gly Trp Gly Leu Ser Val Ser

245 250 255Asp Ala Val Thr Val Asp Asn Leu Ser Asp Thr Val Gln Arg Ile Ala

260 265 270His Leu Phe Met Ala Asn Ile Thr Ala His Pro Ala Asp Trp His Met

275 280 285Leu Gln Pro Leu Trp Phe Gly Asp Leu Asp Pro Glu Arg Leu Lys Arg

290295300 Ser Arg Glu Gln Thr Asn Val His Lys Pro Val Ala Leu Gln Glu 305310315<210>77<211>1389<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1366)<223>RXA00899<400>77tttgctgctc ccctacgtcg gactcccact gttcctgctt atgggatcgc catacatcaa 60ccggtgacgc caccgcatcc aacaagaaat caacgacctc atg gaa gac gtc cac 115

Met Glu Asp Val His

1 5gac gac gtc ccc gac atc ccc acc gga atg gat gtc tcc gcg gaa gtt 163Asp Asp Val Pro Asp Ile Pro Thr Gly Met Asp Val Ser Ala Glu Val

10 15 20gaa tct gtc atc aaa ctc aac cgc cgc ctc acc cgc atg cca gca gtg 211Glu Ser Val Ile Lys Leu Asn Arg Arg Leu Thr Arg Met Pro Ala Val

25 30 35acc ggc gga aac aac ggc ttc tac tcc gac tac cgt gaa tcc ctc aaa 259Thr Gly Gly Asn Asn Gly Phe Tyr Ser Asp Tyr Arg Glu Ser Leu Lys

40 45 50cgg atg acc gcc gca atc gac gaa gcc gaa gaa tac atc tac gtc gag 307Arg Met Thr Ala Ala Ile Asp Glu Ala Glu Glu Tyr Ile Tyr Val Glu

55 60 65atc tac atc atg gcc tgg gat tcc tac acc caa cca ttc ttc gca gca 355Ile Tyr Ile Met Ala Trp Asp Ser Tyr Thr Gln Pro Phe Phe Ala Ala 70 75 80 85ctc gaa cga gcc cac aac cgc ggc gtc aaa gtc cga ctc ctt ttc gac 403Leu Glu Arg Ala His Asn Arg Gly Val Lys Val Arg Leu Leu Phe Asp

90 95100cac gtc ggc agc tgg aaa tac ccc ggc tac cac cgc ctc aaa aaa gaa 451His Val Gly Ser Trp Lys Tyr Pro Gly Tyr His Arg Leu Lys Lys Glu

105 110 115ctc aac cgc atg ggc ttc gcc tgg tac ctc atg ctc ccc ctc caa ccc 499Leu Asn Arg Met Gly Phe Ala Trp Tyr Leu Met Leu Pro Leu Gln Pro

120 125 130tgg cga cgc cgc ttc cgc cga ccc gac ctg cgc aac cac cgc aaa atg 547Trp Arg Arg Arg Phe Arg Arg Pro Asp Leu Arg Asn His Arg Lys Met

135 140 145ctc atc atc gac ggc cac acc gca ttc atg ggc tcc caa aat ctc atc 595Leu Ile Ile Asp Gly His Thr Ala Phe Met Gly Ser Gln Asn Leu Ile150 155 160 165gcc ccg agt tac cta caa aag aaa aac atc aaa ctc ggc cgc gaa tgg 643Ala Pro Ser Tyr Leu Gln Lys Lys Asn Ile Lys Leu Gly Arg Glu Trp

170 175 180aaa gac ctc atg gtc gaa ctc acc ggc ccc atc gtc tcc tcc atg gaa 691Lys Asp Leu Met Val Glu Leu Thr Gly Pro Ile Val Ser Ser Met Glu

185 190 195atg atc ttc gcc ggc gac tgg tac gtc gaa tcc aac gaa gcc ctc gac 739Met Ile Phe Ala Gly Asp Trp Tyr Val Glu Ser Asn Glu Ala Leu Asp

200 205 210atc cgc gac cac gca gaa gcc cac ggc tac atc ggc aac act caa aaa 787Ile Arg Asp His Ala Glu Ala His Gly Tyr Ile Gly Asn Thr Gln Lys

215 220 225gac tcc gcc acc aac ctc gtg cag ctc atc ccc tcc ggc cct ggt tac 835Asp Ser Ala Thr Asn Leu Val Gln Leu Ile Pro Ser Gly Pro Gly Tyr230 235 240 245acc aca gaa ccc aac ctg cgc atg ttc aac tcc atc gtt cac cac gcc 883Tnr Thr Glu Pro Asn Leu Arg Met Phe Asn Ser Ile Val His His Ala

250 255 260aaa gaa cga ctc atc ttg tgc agc ccc tac ttc atc ccc gac gaa tcc 931Lys Glu Arg Leu Ile Leu Cys Ser Pro Tyr Phe Ile Pro Asp Glu Ser

265 270 275ctc ctc gaa gcc gtc acc tca gcc tgc tac cgc gga gta acc gtc gaa 979Leu Leu Glu Ala Val Thr Ser Ala Cys Tyr Arg Gly Val Thr Val Glu

280 285 290cta ttc gtc tct gaa caa gcc gac caa ttc gcc atc gac cac gcc caa 1027Leu Phe Val Ser Glu Gln Ala Asp Gln Phe Ala Ile Asp His Ala Gln

295 300 305tcc tcc tac tac cag gca ctc ctt gaa gcc ggc gtg aaa atc tac caa 1075Ser Ser Tyr Tyr Gln Ala Leu Leu Glu Ala Gly Val Lys Ile Tyr Gln310 315 320 325ttc ccc aaa ccc gac gtc ctc cac acc aag tac atg atc gcc gac ccc 1123Phe Pro Lys Pro Asp Val Leu His Thr Lys Tyr Met Ile Ala Asp Pro

330 335 340gac gac acc acc ggc aac gaa gcc ctc gga gtc ctc gga tcc tcc aac 1171Asp Asp Thr Thr Gly Asn Glu Ala Leu Gly Val Leu Gly Ser Ser Asn

345 350 355ctc gac atc cgc agc ttt ggc ctc aac tac gaa atc tcc ctg atg atc 1219Leu Asp Ile Arg Ser Phe Gly Leu Asn Tyr Glu Ile Ser Leu Met Ile

360 365 370gcc aaa ggc aac ctc atc cac gaa ctc aac gcc ctc acc gac cgt tac 1267Ala Lys Gly Asn Leu Ile His Glu Leu Asn Ala Leu Thr Asp Arg Tyr

375 380 385cgc aca gta agt ttc aag ctc acc ttg gat aag tgg aac cag cgc agt 1315Arg Thr Val Ser Phe Lys Leu Thr Leu Asp Lys Trp Asn Gln Arg Ser390 395 400 405tgg cgg cgc cgc tac gtg gac aat gtc atg cgt ttg acc tcg gcg ctg 1363Trp Arg Arg Arg Tyr Val Asp Asn Val Met Arg Leu Thr Ser Ala Leu

410415420 cag tagtttggcg cgtttggagt gcg 1389Gln<210>78<211>422<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>78Met Glu Asp Val His Asp Asp Val Pro Asp Ile Pro Thr Gly Met Asp 151015 Val Ser Ala Glu Val Glu Ser Val Ile Lys Leu Asn Arg Arg Leu Thr

20 25 30Arg Met Pro Ala Val Thr Gly Gly Asn Asn Gly Phe Tyr Ser Asp Tyr

35 40 45Arg Glu Ser Leu Lys Arg Met Thr Ala Ala Ile Asp Glu Ala Glu Glu

50 55 60Tyr Ile Tyr Val Glu Ile Tyr Ile Met Ala Trp Asp Ser Tyr Thr Gln 65 70 75 80Pro Phe Phe Ala Ala Leu Glu Arg Ala His Asn Arg Gly Val Lys Val

85 90 95Arg Leu Leu Phe Asp His Val Gly Ser Trp Lys Tyr Pro Gly Tyr His

100 105 110Arg Leu Lys Lys Glu Leu Asn Arg Met Gly Phe Ala Trp Tyr Leu Met

115 120 125Leu Pro Leu Gln Pro Trp Arg Arg Arg Phe Arg Arg Pro Asp Leu Arg

130 135 140Asn His Arg Lys Met Leu Ile Ile Asp Gly His Thr Ala Phe Met Gly145 150 155 160Ser Gln Asn Leu Ile Ala Pro Ser Tyr Leu Gln Lys Lys Asn Ile Lys

165 170 175Leu Gly Arg Glu Trp Lys Asp Leu Met Val Glu Leu Thr Gly Pro Ile

180 185 190Val Ser Ser Met Glu Met Ile Phe Ala Gly Asp Trp Tyr Val Glu Ser

195 200 205Asn Glu Ala Leu Asp Ile Arg Asp His Ala Glu Ala His Gly Tyr Ile

210 215 220Gly Asn Thr Gln Lys Asp Ser Ala Thr Asn Leu Val Gln Leu Ile Pro225 230 235 240Ser Gly Pro Gly Tyr Thr Thr Glu Pro Asn Leu Arg Met Phe Asn Ser

245 250 255Ile Val His His Ala Lys Glu Arg Leu Ile Leu Cys Ser Pro Tyr Phe

260 265 270Ile Pro Asp Glu Ser Leu Leu Glu Ala Val Thr Ser Ala Cys Tyr Arg

275 280 285Gly Val Thr Val Glu Leu Phe Val Ser Glu Gln Ala Asp Gln Phe Ala

290 295 300Ile Asp His Ala Gln Ser Ser Tyr Tyr Gln Ala Leu Leu Glu Ala Gly305 310 315 320Val Lys Ile Tyr Gln Phe Pro Lys Pro Asp Val Leu His Thr Lys Tyr

325 330 335Met Ile Ala Asp Pro Asp Asp Thr Thr Gly Asn Glu Ala Leu Gly Val

340 345 350Leu Gly Ser Ser Asn Leu Asp Ile Arg Ser Phe Gly Leu Asn Tyr Glu

355 360 365Ile Ser Leu Met Ile Ala Lys Gly Asn Leu Ile His Glu Leu Asn Ala

370 375 380Leu Thr Asp Arg Tyr Arg Thr Val Ser Phe Lys Leu Thr Leu Asp Lys385 390 395 400Trp Asn Gln Arg Ser Trp Arg Arg Arg Tyr Val Asp Asn Val Met Arg

405 410 415Leu Thr Ser Ala Leu Gln

420<210>79<211>1452<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1429)<223>RXN00819<220><221>misc _ feature<222>1264<223>n stands for any nucleotide<220><221>misc _ feature<222>1267<223>n stands for any nucleotide<220>Misc _ feature<222>1267<223>n stands for any nucleotide<220><221>misc _ feature<222>1279<223>n stands for any nucleotide<220><221>sc _ feature<222>1281<223>n stands for any nucleotide<220><sc><221>misc _ feature<222>5<223>n stands for any nucleotide<220><sc>221>misc _ feature<222>220<223>221<223<220>n stands for any nucleotide<220>misc _ c _ feature<220>223<222<220>nucleotide<220>223<220>221>variables<223>223<223>n Pro, Thr or Ala<220><221>variant<222>394<223>Xaa-Leu, Pro, His or Arg<220><221>variant<222>401<223>Xaa-Tyr, His, Asn or Asp<220><221>variant<222>402<223>Xaa-Ser, Pro, Thr or Ala<400>79gatgaggttc gtccgggaat cctcaaagac aatgcggtga aggtacttgg cctagccgct 60agcactgagc gcggatctca agcagaaaag gtcgtgcaac atg cgt gat ccc att 115

Met Arg Asp Pro Ile

1 5caa ggt gct gtt att cct tct gat ctt ttt ggt ttc gca gaa gtt ctc 163Gln Gly Ala Val Ile Pro Ser Asp Leu Phe Gly Phe Ala Glu Val Leu

10 15 20acc gaa gcc gaa cgc gca gtt ctt ctg gaa acc cgc agg gtg ctt gag 211Thr Glu Ala Glu Arg Ala Val Leu Leu Glu Thr Arg Arg Val Leu Glu

25 30 35gaa gag gtg aag cct tat att aat gag gcc tgg gat aag gca gtc ttc 259Glu Glu Val Lys Pro Tyr Ile Asn Glu Ala Trp Asp Lys Ala Val Phe

40 45 50ccc gat gag atc gtg cag ccc ctc caa gat ctg caa ttg ctt gat ccg 307Pro Asp Glu Ile Val Gln Pro Leu Gln Asp Leu Gln Leu Leu Asp Pro

55 60 65cct gca ctt cgg gaa gca ggg gag tcg gtt cga gac att ttc act ggt 355Pro Ala Leu Arg Glu Ala Gly Glu Ser Val Arg Asp Ile Phe Thr Gly 70 75 80 85ttc cgc aat ttt gaa ctc gcg cgc tgt gac atc aat gtt ggt acc tat 403Phe Arg Asn Phe Glu Leu Ala Arg Cys Asp Ile Asn Val Gly Thr Tyr

90 95 100tac aac gca tct gct ggt ctc ttc cga acg gcc tgc atg gtt ggt ggc 451Tyr Asn Ala Ser Ala Gly Leu Phe Arg Thr Ala Cys Met Val Gly Gly

105 110 115tcc ccg gag cag gcg cag cga ttg gat gcg cag atc aaa tct ggt gag 499Ser Pro Glu Gln Ala Gln Arg Leu Asp Ala Gln Ile Lys Ser Gly Glu

120 125 130gtc aag ggc gtt ttt gca ctg acg gaa cct gat cat ggc tct gat atc 547Val Lys Gly Val Phe Ala Leu Thr Glu Pro Asp His Gly Ser Asp Ile

135 140 145gca ggt ggt ctg gca acc acg gcc act aag gac gca gac acc ggc gag 595Ala Gly Gly Leu Ala Thr Thr Ala Thr Lys Asp Ala Asp Thr Gly Glu150 155 160 165tgg att atc aat ggt gaa aaa cgg tgg atc ggt ggt gct tcc act gct 643Trp Ile Ile Asn Gly Glu Lys Arg Trp Ile Gly Gly Ala Ser Thr Ala

170 175 180gat ttg atc gct acc ttc gcc agg gat aca gcc gat aac cag gtg aaa 691Asp Leu Ile Ala Thr Phe Ala Arg Asp Thr Ala Asp Asn Gln Val Lys

185 190 195tgc ttc ctc gtg gca cct cag gca gag ggc gtg tcc atg gag att att 739Cys Phe Leu Val Ala Pro Gln Ala Glu Gly Val Ser Met Glu Ile Ile

200 205 210gat cgc aaa gcc tca ctg cgc atc atg caa aat gca cac att acc tat 787Asp Arg Lys Ala Ser Leu Arg Ile Met Gln Asn Ala His Ile Thr Tyr

215 220 225aac aat gtc cgg gtg tct ggg gat gcg cgg ctg cac aac atc aat tct 835Asn Asn Val Arg Val Ser Gly Asp Ala Arg Leu His Asn Ile Asn Ser230 235 240 245ttc aag gat gtt tcg gaa tgc ctg cgc cgt atg cgt tcc gat gtg gcg 883Phe Lys Asp Val Ser Glu Cys Leu Arg Arg Met Arg Ser Asp Val Ala

250 255 260tgg atg gcg gtc ggt gcg cag gca ggt gcc tat gaa gca gcc gtg aag 931Trp Met Ala Val Gly Ala Gln Ala Gly Ala Tyr Glu Ala Ala Val Lys

265 270 275tat gtg cgc agc agg gaa cag ttt ggc cgt ccg arc gcg ggg ttc cag 979Tyr Val Arg Ser Arg Glu Gln Phe Gly Arg Pro Ile Ala Gly Phe Gln

280 285 290ttg att cag gaa aag ctc gcg ctc atg ctg ggc aat ctc acg gcg tcg 1027Leu Ile Gln Glu Lys Leu Ala Leu Met Leu Gly Asn Leu Thr Ala Ser

295 300 305ctg ggc atg atg gtc aaa ctc acc gat cag cag cag gcg gga att ttc 1075Leu Gly Met Met Val Lys Leu Thr Asp Gln Gln Gln Ala Gly Ile Phe310 315 320 325aaa gag gaa aac tcc gcg ctg gcg aaa atg ttt acc tcg ctc aaa ctt 1123Lys Glu Glu Asn Ser Ala Leu Ala Lys Met Phe Thr Ser Leu Lys Leu

330 335 340cgg gag acc gct agt tgg gcg cgg gaa atc tgc gga ggc aac ggc atc 1171Arg Glu Thr Ala Ser Trp Ala Arg Glu Ile Cys Gly Gly Asn Gly Ile

345 350 355att ttg gac aac gat gtt gcc cgg ttc cat gcc gat gca gaa gcc gtc 1219Ile Leu Asp Asn Asp Val Ala Arg Phe His Ala Asp Ala Glu Ala Val

360 365 370tat tca tat gaa ggc acc cac gaa atc aat gca ctc atc gtt ggn cgn 1267Tyr Ser Tyr Glu Gly Thr His Glu Ile Asn Ala Leu Ile Val Gly Arg

375 380 385ncc att ctg ggn cnt ctn ttc ttt tta tat tat nac nct ttt gag gag 1315Xaa Ile Leu Gly Xaa Leu Phe Phe Leu Tyr Tyr Xaa Xaa Phe Glu Glu390 395 400 405gat ctt cat gac tac ttc cac cac ccc aaa cca tcg ttt ctt tcg aag 1363Asp Leu His Asp Tyr Phe His His Pro Lys Pro Ser Phe Leu Ser Lys

410 415 420acg cac caa ccc tca ccg gcc agg acc tgg gct ttt cgc agt ggc gca 1411Thr His Gln Pro Ser Pro Ala Arg Thr Trp Ala Phe Arg Ser Gly Ala

425 430 435ctg tca ccc agg aga tgg tgaacacctt ggcggacgca act 1452Leu Ser Pro Arg Arg Trp

440<210>80<211>443<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>variant<222>390<223>Xaa ═ Ser, Pro, Thr or Ala<220><221>variant<222>394<223>Xaa ═ Leu, Pro, His or Arg<220><221>variant<222>401<223>Xaa ═ Tyr, His, Asn or Asp<220><221>variant<222>402<223>Xaa ═ Ser, Pro, Thr or Ala<400>80Met Arg Asp Pro Ile Gln Gly Ala Val Ile Pro Ser Asp Leu Phe Gly 151015 Phe Ala Glu Val Leu Thr Glu Ala Glu Arg Ala Val Leu Leu Glu Thr

20 25 30Arg Arg Val Leu Glu Glu Glu Val Lys Pro Tyr Ile Asn Glu Ala Trp

35 40 45Asp Lys Ala Val Phe Pro Asp Glu Ile Val Gln Pro Leu Gln Asp Leu

50 55 60Gln Leu Leu Asp Pro Pro Ala Leu Arg Glu Ala Gly Glu Ser Val Arg 65 70 75 80Asp Ile Phe Thr Gly Phe Arg Asn Phe Glu Leu Ala Arg Cys Asp Ile

85 90 95Asn Val Gly Thr Tyr Tyr Asn Ala Ser Ala Gly Leu Phe Arg Thr Ala

100 105 110Cys Met Val Gly Gly Ser Pro Glu Gln Ala Gln Arg Leu Asp Ala Gln

115 120 125Ile Lys Ser Gly Glu Val Lys Gly Val Phe Ala Leu Thr Glu Pro Asp

130 135 140His Gly Ser Asp Ile Ala Gly Gly Leu Ala Thr Thr Ala Thr Lys Asp145 150 155 160Ala Asp Thr Gly Glu Trp Ile Ile Asn Gly Glu Lys Arg Trp Ile Gly

165 170 175Gly Ala Ser Thr Ala Asp Leu Ile Ala Thr Phe Ala Arg Asp Thr Ala

180 185 190Asp Asn Gln Val Lys Cys Phe Leu Val Ala Pro Gln Ala Glu Gly Val

195 200 205Ser Met Glu Ile Ile Asp Arg Lys Ala Ser Leu Arg Ile Met Gln Asn

210 215 220Ala His Ile Thr Tyr Asn Asn Val Arg Val Ser Gly Asp Ala Arg Leu225 230 235 240His Asn Ile Asn Ser Phe Lys Asp Val Ser Glu Cys Leu Arg Arg Met

245 250 255Arg Ser Asp Val Ala Trp Met Ala Val Gly Ala Gln Ala Gly Ala Tyr

260 265 270Glu Ala Ala Val Lys Tyr Val Arg Ser Arg Glu Gln Phe Gly Arg Pro

275 280 285Ile Ala Gly Phe Gln Leu Ile Gln Glu Lys Leu Ala Leu Met Leu Gly

290 295 300Asn Leu Thr Ala Ser Leu Gly Met Met Val Lys Leu Thr Asp Gln Gln305 310 315 320Gln Ala Gly Ile Phe Lys Glu Glu Asn Ser Ala Leu Ala Lys Met Phe

325 330 335Thr Ser Leu Lys Leu Arg Glu Thr Ala Ser Trp Ala Arg Glu Ile Cys

340 345 350Gly Gly Asn Gly Ile Ile Leu Asp Asn Asp Val Ala Arg Phe His Ala

355 360 365Asp Ala Glu Ala Val Tyr Ser Tyr Glu Gly Thr His Glu Ile Asn Ala

370 375 380Leu Ile Val Gly Arg Xaa Ile Leu Gly Xaa Leu Phe Phe Leu Tyr Tyr385 390 395 400Xaa Xaa Phe Glu Glu Asp Leu His Asp Tyr Phe His His Pro Lys Pro

405 410 415Ser Phe Leu Ser Lys Thr His Gln Pro Ser Pro Ala Arg Thr Trp Ala

420 425 430Phe Arg Ser Gly Ala Leu Ser Pro Arg Arg Trp

435440<210>81<211>1030<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(18) } (1007)<223>FRXA00819<220><22l>misc _ feature<222>842<223>n represents any nucleotide<220><221>misc _ feature<222>845<223>n represents any nucleotide<220><221>misc _ feature<222>Ser<857<223>n represents any nucleotide<220><221>scsC _ feature<222>859<223>n represents any nucleotide<220><221><scsC _ feature<222>223>220<223>221><221>misc _ feature<222>863<223>n represents any nucleotide<220>220<221>misc _ feature<222<223>mutation<223>n represents any nucleotide<220>220<220>XaaNo<223>mutant<223>n<223>220<220>Xac _ feature<222<223>mutation<223>n<223>mutation<220>mutation<223>n<220, Pro, Thr or Ala<220><221>variant<222>281<223>Xaa ═ Leu, Pro, His or Arg<220><221>variant<222>288<223>Xaa ═ Tyr, His, Asn or Asp<220><221>variant<222>289<223>Xaa ═ Ser, Pro, Thr or Ala<400>81tcttccgaac ggcctgc atg gtt ggt ggc tcc ccg gag cag gcg cag cga 50

Met Val Gly Gly Ser Pro Glu Gln Ala Gln Arg

1 5 10ttg gat gcg cag atc aaa tct ggt gag gtc aag ggc gtt ttt gca ctg 98Leu Asp Ala Gln Ile Lys Ser Gly Glu Val Lys Gly Val Phe Ala Leu

15 20 25acg gaa cct gat cat ggc tct gat atc gca ggt ggt ctg gca acc acg 146Thr Glu Pro Asp His Gly Ser Asp Ile Ala Gly Gly Leu Ala Thr Thr

30 35 40gcc act aag gac gca gac acc ggc gag tgg att atc aat ggt gaa aaa 194Ala Thr Lys Asp Ala Asp Thr Gly Glu Trp Ile Ile Asn Gly Glu Lys

4550 55cgg tgg atc ggt ggt gct tcc act gct gat ttg atc gct acc ttc gcc 242Arg Trp Ile Gly Gly Ala Ser Thr Ala Asp Leu Ile Ala Thr Phe Ala 60 65 70 75agg gat aca gcc gat aac cag gtg aaa tgc ttc ctc gtg gca cct cag 290Arg Asp Thr Ala Asp Asn Gln Val Lys Cys Phe Leu Val Ala Pro Gln

80 85 90gca gag ggc gtg tcc atg gag att att gat cgc aaa gcc tca ctg cgc 338Ala Glu Gly Val Ser Met Glu Ile Ile Asp Arg Lys Ala Ser Leu Arg

95 100 105atc atg caa aat gca cac att acc tat aac aat gtc cgg gtg tct ggg 386Ile Met Gln Asn Ala His Ile Thr Tyr Asn Asn Val Arg Val Ser Gly

110 115 120gat gcg cgg ctg cac aac atc aat tct ttc aag gat gtt tcg gaa tgc 434Asp Ala Arg Leu His Asn Ile Asn Ser Phe Lys Asp Val Ser Glu Cys

125 130 135ctg cgc cgt atg cgt tcc gat gtg gcg tgg atg gcg gtc ggt gcg cag 482Leu Arg Arg Met Arg Ser Asp Val Ala Trp Met Ala Val Gly Ala Gln140 145 150 155gca ggt gcc tat gaa gca gcc gtg aag tat gtg cgc agc agg gaa cag 530Ala Gly Ala Tyr Glu Ala Ala Val Lys Tyr Val Arg Ser Arg Glu Gln

160 165 170ttt ggc cgt ccg atc gcg ggg ttc cag ttg att cag gaa aag ctc gcg 578Phe Gly Arg Pro Ile Ala Gly Phe Gln Leu Ile Gln Glu Lys Leu Ala

175 180 185ctc atg ctg ggc aat ctc acg gcg tcg ctg ggc atg atg gtc aaa ctc 626Leu Met Leu Gly Asn Leu Thr Ala Ser Leu Gly Met Met Val Lys Leu

190 195 200acc gat cag cag cag gcg gga att ttc aaa gag gaa aac tcc gcg ctg 674Thr Asp Gln Gln Gln Ala Gly Ile Phe Lys Glu Glu Asn Ser Ala Leu

205 210 215gcg aaa atg ttt acc tcg ctc aaa ctt cgg gag acc gct agt tgg gcg 722Ala Lys Met Phe Thr Ser Leu Lys Leu Arg Glu Thr Ala Ser Trp Ala220 225 230 235cgg gaa atc tgc gga ggc aac ggc atc att ttg gac aac gat gtt gcc 770Arg Glu Ile Cys Gly Gly Asn Gly Ile Ile Leu Asp Asn Asp Val Ala

240 245 250cgg ttc cat gcc gat gca gaa gcc gtc tat tca tat gaa ggc acc cac 818Arg Phe His Ala Asp Ala Glu Ala Val Tyr Ser Tyr Glu Gly Thr His

255 260 265gaa atc aat gca ctc atc gtt ggn cgn ncc att ctg ggn cnt ctn ttc 866Glu Ile Asn Ala Leu Ile Val Gly Arg Xaa Ile Leu Gly Xaa Leu Phe

270 275 280ttt tta tat tat nac nct ttt gag gag gat ctt cat gac tac ttc cac 914Phe Leu Tyr Tyr Xaa Xaa Phe Glu Glu Asp Leu His Asp Tyr Phe His

285 290 295cac ccc aaa cca tcg ttt ctt tcg aag acg cac caa ccc tca ccg gcc 962His Pro Lys Pro Ser Phe Leu Ser Lys Thr His Gln Pro Ser Pro Ala300 305 310 315agg acc tgg gct ttt cgc agt ggc gca ctg tca ccc agg aga tgg 1007Arg Thr Trp Ala Phe Arg Ser Gly Ala Leu Ser Pro Arg Arg Trp

320325330 tgaacacctt cgcggacgca act<210>82<211>330<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>variant<222>277<223>Xaa ═ Ser, Pro, Thr or Ala<220><221>variant<222>281<223>Xaa ═ Leu, Pro, His or Arg<220><221>variant<222>288<223>Xaa ═ Tyr, His, Asn or Asp<220><221>variant<222>289<223>Xaa═ Ser, Pro, Thr or Ala<400>82 3615132 015 Lys Ser Gly Glu Val Lys Gly Val Phe Ala Leu Thr Glu Pro Asp His

20 25 30Gly Ser Asp Ile Ala Gly Gly Leu Ala Thr Thr Ala Thr Lys Asp Ala

35 40 45Asp Thr Gly Glu Trp Ile Ile Asn Gly Glu Lys Arg Trp Ile Gly Gly

50 55 60Ala Ser Thr Ala Asp Leu Ile Ala Thr Phe Ala Arg Asp Thr Ala Asp 65 70 75 80Asn Gln Val Lys Cys Phe Leu Val Ala Pro Gln Ala Glu Gly Val Ser

85 90 95Met Glu Ile Ile Asp Arg Lys Ala Ser Leu Arg Ile Met Gln Asn Ala

100 105 110His Ile Thr Tyr Asn Asn Val Arg Val Ser Gly Asp Ala Arg Leu His

115 120 125Asn Ile Asn Ser Phe Lys Asp Val Ser Glu Cys Leu Arg Arg Met Arg

130 135 140Ser Asp Val Ala Trp Met Ala Val Gly Ala Gln Ala Gly Ala Tyr Glu145 150 155 160Ala Ala Val Lys Tyr Val Arg Ser Arg Glu Gln Phe Gly Arg Pro Ile

165 170 175Ala Gly Phe Gln Leu Ile Gln Glu Lys Leu Ala Leu Met Leu Gly Asn

180 185 190Leu Thr Ala Ser Leu Gly Met Met Val Lys Leu Thr Asp Gln Gln Gln

195 200 205Ala Gly Ile Phe Lys Glu Glu Asn Ser Ala Leu Ala Lys Met Phe Thr

210 215 220Ser Leu Lys Leu Arg Glu Thr Ala Ser Trp Ala Arg Glu Ile Cys Gly225 230 235240Gly Asn Gly Ile Ile Leu Asp Asn Asp Val Ala Arg Phe His Ala Asp

245 250 255Ala Glu Ala Val Tyr Ser Tyr Glu Gly Thr His Glu Ile Asn Ala Leu

260 265 270Ile Val Gly Arg Xaa Ile Leu Gly Xaa Leu Phe Phe Leu Tyr Tyr Xaa

275 280 285Xaa Phe Glu Glu Asp Leu His Asp Tyr Phe His His Pro Lys Pro Ser

290 295 300Phe Leu Ser Lys Thr His Gln Pro Ser Pro Ala Arg Thr Trp Ala Phe305 310 315 320Arg Ser Gly Ala Leu Ser Pro Arg Arg Trp

325330<210>83<211>391<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (391)<223>FRXA01766<400>83gatgaggttc gtccgggaat cctcaaagac aatgcggtga aggtacttgg cctagccgct 60agcactgagc gcggatctca agcagaaaag gtcgtgcaac atg cgt gat ccc att 115

Met Arg Asp Pro Ile

1 5caa ggt gct gtt att cct tct gat ctt ttt ggt ttc gca gaa gtt ctc 163Gln Gly Ala Val Ile Pro Ser Asp Leu Phe Gly Phe Ala Glu Val Leu

10 15 20acc gaa gcc gaa cgc gca gtt ctt ctg gaa acc cgc agg gtg ctt gag 211Thr Glu Ala Glu Arg Ala Val Leu Leu Glu Thr Arg Arg Val Leu Glu

25 30 35gaa gag gtg aag cct tat att aat gag gcc tgg gat aag gca gtc ttc 259Glu Glu Val Lys Pro Tyr Ile Asn Glu Ala Trp Asp Lys Ala Val Phe

40 45 50ccc gat gag atc gtg cag ccc ctccaa gat ctg caa ttg ctt gat ccg 307Pro Asp Glu Ile Val Gln Pro Leu Gln Asp Leu Gln Leu Leu Asp Pro

55 60 65cct gca ctt cgg gaa gca ggg gag tcg gtt cga gac att ttc act ggt 355Pro Ala Leu Arg Glu Ala Gly Glu Ser Val Arg Asp Ile Phe Thr Gly 70 75 80 85ttc cgc aat ttt gaa ctc gcg cgc tgt gac atc aat 391Phe Arg Asn Phe Glu Leu Ala Arg Cys Asp Ile Asn

9095<210>84<211>97<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>84Met Arg Asp Pro Ile Gln Gly Ala Val Ile Pro Ser Asp Leu Phe Gly 151015 Phe Ala Glu Val Leu Thr Glu Ala Glu Arg Ala Val Leu Leu Glu Thr

20 25 30Arg Arg Val Leu Glu Glu Glu Val Lys Pro Tyr Ile Asn Glu Ala Trp

35 40 45Asp Lys Ala Val Phe Pro Asp Glu Ile Val Gln Pro Leu Gln Asp Leu

50 55 60Gln Leu Leu Asp Pro Pro Ala Leu Arg Glu Ala Gly Glu Ser Val Arg 65 70 75 80Asp Ile Phe Thr Gly Phe Arg Asn Phe Glu Leu Ala Arg Cys Asp Ile

859095 Asn<210>85<211>1659<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1636)<223>RXN01762<400>85tggagtgatg aattttccta tagaacgttt tttaaacgat tgacttttta aacgtttacg 60cttttaatga cttcaaacgt gatctaaagc acaaaggaga atg aaa gtg aac ctc 115

Met Lys Val Asn Leu

1 5gga ata gga agc tac cca cga cgc agg gca act gtt cga cca gag tcc 163Gly Ile Gly Ser Tyr Pro Arg Arg Arg Ala Thr Val Arg Pro Glu Ser

10 15 20act gca atc gaa ttc gaa ggc acc agc atc acc tac gga gaa ttc agc 211Thr Ala Ile Glu Phe Glu Gly Thr Ser Ile Thr Tyr Gly Glu Phe Ser

25 30 35aaa cga gtc aat cgg ctt gga cat gct ctt cta gac ctc ggc gtt gcg 259Lys Arg Val Asn Arg Leu Gly His Ala Leu Leu Asp Leu Gly Val Ala

40 45 50cac caa gat cga gta gct tat gtc gga ttc aac cac cct gcc ctg cta 307His Gln Asp Arg Val Ala Tyr Val Gly Phe Asn His Pro Ala Leu Leu

55 60 65gaa gtg ttc ttt tca acg aac ctc att ggg gca aca ccc gtg ctt gtt 355Glu Val Phe Phe Ser Thr Asn Leu Ile Gly Ala Thr Pro Val Leu Val 70 75 80 85aac cct cgc cta tcg gca aac gaa atc gat tac atc atc caa gac agc 403Asn Pro Arg Leu Ser Ala Asn Glu Ile Asp Tyr Ile Ile Gln Asp Ser

90 95 100ggt gcg agc atc gtg ttt tac gga atc gac ctc atc gag cac gcc act 451Gly Ala Ser Ile Val Phe Tyr Gly Ile Asp Leu Ile Glu His Ala Thr

105 110 115tac ctc caa gaa ctc cat cca gag atc atc atg gtg gcc gtt gaa ggc 499Tyr Leu Gln Glu Leu His Pro Glu Ile Ile Met Val Ala Val Glu Gly

120 125 130gat gag ggt cca ggt ttg cgt cga aaa gcg ctt att gaa gcg gcg agc 547Asp Glu Gly Pro Gly Leu Arg Arg Lys Ala Leu Ile Glu Ala Ala Ser

135 140 145gac gcc gac atc gac cta gaa gtc agc gat gat gac ctg gtg ctg ctc 595Asp Ala Asp Ile Asp Leu Glu Val Ser Asp Asp Asp Leu Val Leu Leu150 155 160165atg tac acc tcc gga acc act ggc cgc cca aag ggc gcc atg tta tcc 643Met Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Ala Met Leu Ser

170 175 180cac cga aac ctc ttc ttt aac tac ttc aat gcc ctg ctc agc cag gaa 691His Arg Asn Leu Phe Phe Asn Tyr Phe Asn Ala Leu Leu Ser Gln Glu

185 190 195att gaa caa ggc gcg gta ctt tta tcc act gcg ccg tta ttc cac atc 739Ile Glu Gln Gly Ala Val Leu Leu Ser Thr Ala Pro Leu Phe His Ile

200 205 210gcg ggc ctc aac atg acc acc atc ccg gtg atg atg aag ggc gga aag 787Ala Gly Leu Asn Met Thr Thr Ile Pro Val Met Met Lys Gly Gly Lys

215 220 225gtg atc atc cac cgc gaa ttc cgg gca gag cac gtc ctc gac gaa atc 835Val Ile Ile His Arg Glu Phe Arg Ala Glu His Val Leu Asp Glu Ile230 235 240 245gaa cgc tcc aag gta tcc gaa tcc ttc atg gtg cca gcg atg atc gac 883Glu Arg Ser Lys Val Ser Glu Ser Phe Met Val Pro Ala Met Ile Asp

250 255 260atg ttg tcc aac cac cca tca ttt gcc gaa cgc gac ctt tct tcc ctt 931Met Leu Ser Asn His Pro Ser Phe Ala Glu Arg Asp Leu Ser Ser Leu

265 270 275cgc gcc atc atg gtg ggc ggc tct ccc ctt agc gaa cgt gcg ctg cga 979Arg Ala Ile Met Val Gly Gly Ser Pro Leu Ser Glu Arg Ala Leu Arg

280 285 290atc tgg caa gga cgc gac gta aaa att gtc caa ggc ttc ggc atg aca 1027Ile Trp Gln Gly Arg Asp Val Lys Ile Val Gln Gly Phe Gly Met Thr

295 300 305gaa acc gca ccg ggc gcc tgt atc ctc gag gca aca gac aca agc aca 1075Glu Thr Ala Pro Gly Ala Cys Ile Leu Glu Ala Thr Asp Thr Ser Thr310 315 320 325cac ctt gga acc gca ggt cga gcc cac ttc ttc acc gac atc aaa cta 1123His Leu Gly Thr Ala Gly Arg Ala His Phe Phe Thr Asp Ile Lys Leu

330 335 340gtg gac ccg aaa acc ggc gaa gaa gtc ccc acc gga gag gcc ggc gaa 1171Val Asp Pro Lys Thr Gly Glu Glu Val Pro Thr Gly Glu Ala Gly Glu

345 350 355gtt ctc atc cgc gga cca cat gtg atg acc gga tac tgg aac cga cca 1219Val Leu Ile Arg Gly Pro His Val Met Thr Gly Tyr Trp Asn Arg Pro

360 365 370gaa gac acc gcc agc gca cta caa aat ggc tgg tac cac tcc gga gat 1267Glu Asp Thr Ala Ser Ala Leu Gln Asn Gly Trp Tyr His Ser Gly Asp

375 380 385atc gcc atc aaa gat gaa gac ggc tac tac acc atc aaa gac cgc atc 1315Ile Ala Ile Lys Asp Glu Asp Gly Tyr Tyr Thr Ile Lys Asp Arg Ile390 395 400 405aaa gac atg tac atc tcc ggc ggc gaa aac att tac ccc gca gaa gtc 1363Lys Asp Met Tyr Ile Ser Gly Gly Glu Asn Ile Tyr Pro Ala Glu Val

410 415 420gaa caa gca ctc cag gaa ctg gaa gca gtc ctt gat gcc gca gtc atc 1411Glu Gln Ala Leu Gln Glu Leu Glu Ala Val Leu Asp Ala Ala Val Ile

425 430 435gga gtc ccc gat gaa cga tgg ggc gaa act ggc atc gcc ttt gtc tcc 1459Gly Val Pro Asp Glu Arg Trp Gly Glu Thr Gly Ile Ala Phe Val Ser

440 445 450atc cga gaa agc tac ctg acc aac cca cca acc gga ccg gaa cta cga 1507Ile Arg Glu Ser Tyr Leu Thr Asn Pro Pro Thr Gly Pro Glu Leu Arg

455 460 465gaa cta cta ggc agt gtc cta gcc aga tac aaa ctt cca cga gaa atc 1555Glu Leu Leu Gly Ser Val Leu Ala Arg Tyr Lys Leu Pro Arg Glu Ile470 475 480 485cac atc atc gaa gaa ctc ccc cgc aac gcc aca ggc aaa atc caa aag 1603His Ile Ile Glu Glu Leu Pro Arg Asn Ala Thr Gly Lys Ile Gln Lys

490 495 500aac atc ctg cga gac ttc acc atc ccc gtt tca taaacccccc aacgtcactt 1656Asn Ile Leu Arg Asp Phe Thr Ile Pro Val Ser

505510 tga1659<210>86<211>512<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>86Met Lys Val Asn Leu Gly Ile Gly Ser Tyr Pro Arg Arg Arg Ala Thr 151015 Val Arg Pro Glu Ser Thr Ala Ile Glu Phe Glu Gly Thr Ser Ile Thr

20 25 30Tyr Gly Glu Phe Ser Lys Arg Val Asn Arg Leu Gly His Ala Leu Leu

35 40 45Asp Leu Gly Val Ala His Gln Asp Arg Val Ala Tyr Val Gly Phe Asn

50 55 60His Pro Ala Leu Leu Glu Val Phe Phe Ser Thr Asn Leu Ile Gly Ala 65 70 75 80Thr Pro Val Leu Val Asn Pro Arg Leu Ser Ala Asn Glu Ile Asp Tyr

85 90 95Ile Ile Gln Asp Ser Gly Ala Ser Ile Val Phe Tyr Gly Ile Asp Leu

100 105 110Ile Glu His Ala Thr Tyr Leu Gln Glu Leu His Pro Glu Ile Ile Met

115 120 125Val Ala Val Glu Gly Asp Glu Gly Pro Gly Leu Arg Arg Lys Ala Leu

130 135 140Ile Glu Ala Ala Ser Asp Ala Asp Ile Asp Leu Glu Val Ser Asp Asp145 150155 160Asp Leu Val Leu Leu Met Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys

165 170 175Gly Ala Met Leu Ser His Arg Asn Leu Phe Phe Asn Tyr Phe Asn Ala

180 185 190Leu Leu Ser Gln Glu Ile Glu Gln Gly Ala Val Leu Leu Ser Thr Ala

195 200 205Pro Leu Phe His Ile Ala Gly Leu Asn Met Thr Thr Ile Pro Val Met

210 215 220Met Lys Gly Gly Lys Val Ile Ile His Arg Glu Phe Arg Ala Glu His225 230 235 240Val Leu Asp Glu Ile Glu Arg Ser Lys Val Ser Glu Ser Phe Met Val

245 250 255Pro Ala Met Ile Asp Met Leu Ser Asn His Pro Ser Phe Ala Glu Arg

260 265 270Asp Leu Ser Ser Leu Arg Ala Ile Met Val Gly Gly Ser Pro Leu Ser

275 280 285Glu Arg Ala Leu Arg Ile Trp Gln Gly Arg Asp Val Lys Ile Val Gln

290 295 300Gly Phe Gly Met Thr Glu Thr Ala Pro Gly Ala Cys Ile Leu Glu Ala305 310 315 320Thr Asp Thr Ser Thr His Leu Gly Thr Ala Gly Arg Ala His Phe Phe

325 330 335Thr Asp Ile Lys Leu Val Asp Pro Lys Thr Gly Glu Glu Val Pro Thr

340 345 350Gly Glu Ala Gly Glu Val Leu Ile Arg Gly Pro His Val Met Thr Gly

355 360 365Tyr Trp Asn Arg Pro Glu Asp Thr Ala Ser Ala Leu Gln Asn Gly Trp

370 375 380Tyr His Ser Gly Asp Ile Ala Ile Lys Asp Glu Asp Gly Tyr Tyr Thr385 390 395 400Ile Lys Asp Arg Ile Lys Asp Met Tyr Ile Ser Gly Gly Glu Asn Ile

405 410 415Tyr Pro Ala Glu Val Glu Gln Ala Leu Gln Glu Leu Glu Ala Val Leu

420 425 430Asp Ala Ala Val Ile Gly Val Pro Asp Glu Arg Trp Gly Glu Thr Gly

435 440 445Ile Ala Phe Val Ser Ile Arg Glu Ser Tyr Leu Thr Asn Pro Pro Thr

450 455 460Gly Pro Glu Leu Arg Glu Leu Leu Gly Ser Val Leu Ala Arg Tyr Lys465 470 475 480Leu Pro Arg Glu Ile His Ile Ile Glu Glu Leu Pro Arg Asn Ala Thr

485 490 495Gly Lys Ile Gln Lys Asn Ile Leu Arg Asp Phe Thr Ile Pro Val Ser

500505510<210>87<211>1372<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1363)<223>FRXA01762<400>87tggagtgatg aattttccta tagaacgttt tttaaacgat tgacttttta aacgtttacg 60cttttaatga cttcaaacgt gatctaaagc acaaaggaga atg aaa gtg aac ctc 115

Met Lys Val Asn Leu

1 5gga ata gga agc tac cca cga cgc agg gca act gtt cga cca gag tcc 163Gly Ile Gly Ser Tyr Pro Arg Arg Arg Ala Thr Val Arg Pro Glu Ser

10 15 20act gca atc gaa ttc gaa ggc acc agc atc acc tac gga gaa ttc agc 211Thr Ala Ile Glu Phe Glu Gly Thr Ser Ile Thr Tyr Gly GluPhe Ser

25 30 35aaa cga gtc aat cgg ctt gga cat gct ctt cta gac ctc ggc gtt gcg 259Lys Arg Val Asn Arg Leu Gly His Ala Leu Leu Asp Leu Gly Val Ala

40 45 50cac caa gat cga gta gct tat gtc gga ttc aac cac cct gcc ctg cta 307His Gln Asp Arg Val Ala Tyr Val Gly Phe Asn His Pro Ala Leu Leu

55 60 65gaa gtg ttc ttt tca acg aac ctc att ggg gca aca ccc gtg ctt gtt 355Glu Val Phe Phe Ser Thr Asn Leu Ile Gly Ala Thr Pro Val Leu Val 70 75 80 85aac cct cgc cta tcg gca aac gaa atc gat tac atc atc caa gac agc 403Asn Pro Arg Leu Ser Ala Asn Glu Ile Asp Tyr Ile Ile Gln Asp Ser

90 95 100ggt gcg agc atc gtg ttt tac gga atc gac ctc atc gag cac gcc act 451Gly Ala Ser Ile Val Phe Tyr Gly Ile Asp Leu Ile Glu His Ala Thr

105 110 115tac ctc caa gaa ctc cat cca gag atc atc atg gtg gcc gtt gaa ggc 499Tyr Leu Gln Glu Leu His Pro Glu Ile Ile Met Val Ala Val Glu Gly

120 125 130gat gag ggt cca ggt ttg cgt cga aaa gcg ctt att gaa gcg gcg agc 547Asp Glu Gly Pro Gly Leu Arg Arg Lys Ala Leu Ile Glu Ala Ala Ser

135 140 145gac gcc gac atc gac cta gaa gtc agc gat gat gac ctg gtg ctg ctc 595Asp Ala Asp Ile Asp Leu Glu Val Ser Asp Asp Asp Leu Val Leu Leu150 155 160 165atg tac acc tcc gga acc act ggc cgc cca aag ggc gcc atg tta tcc 643Met Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys Gly Ala Met Leu Ser

170 175 180cac cga aac ctc ttc ttt aac tac ttc aat gcc ctg ctc agc cag gaa 691His Arg Asn Leu Phe Phe Asn Tyr Phe Asn Ala Leu Leu Ser Gln Glu

185 190 195att gaa caa ggc gcg gta ctt tta tcc act gcg ccg tta ttc cac atc 739Ile Glu Gln Gly Ala Val Leu Leu Ser Thr Ala Pro Leu Phe His Ile

200 205 210gcg ggc ctc aac atg acc acc atc ccg gtg atg atg aag ggc gga aag 787Ala Gly Leu Asn Met Thr Thr Ile Pro Val Met Met Lys Gly Gly Lys

215 220 225gtg atc atc cac cgc gaa ttc cgg gca gag cac gtc ctc gac gaa atc 835Val Ile Ile His Arg Glu Phe Arg Ala Glu His Val Leu Asp Glu Ile230 235 240 245gaa cgc tcc aag gta tcc gaa tcc ttc atg gtg cca gcg atg atc gac 883Glu Arg Ser Lys Val Ser Glu Ser Phe Met Val Pro Ala Met Ile Asp

250 255 260atg ttg tcc aac cac cca tca ttt gcc gaa cgc gac ctt tct tcc ctt 931Met Leu Ser Asn His Pro Ser Phe Ala Glu Arg Asp Leu Ser Ser Leu

265 270 275cgc gcc atc atg gtg ggc ggc tct ccc ctt agc gaa cgt gcg ctg cga 979Arg Ala Ile Met Val Gly Gly Ser Pro Leu Ser Glu Arg Ala Leu Arg

280 285 290atc tgg caa gga cgc gac gta aaa att gtc caa ggc ttc ggc atg aca 1027Ile Trp Gln Gly Arg Asp Val Lys Ile Val Gln Gly Phe Gly Met Thr

295 300 305gaa acc gca ccg ggc gcc tgt atc ctc gag gca aca gac aca agc aca 1075Glu Thr Ala Pro Gly Ala Cys Ile Leu Glu Ala Thr Asp Thr Ser Thr310 315 320 325cac ctt gga acc gca ggt cga gcc cac ttc ttc acc gac atc aaa cta 1123His Leu Gly Thr Ala Gly Arg Ala His Phe Phe Thr Asp Ile Lys Leu

330 335 340gtg gac ccg aaa acc ggc gaa gaa gtc ccc acc gga gag gcc ggc gaa 1171Val Asp Pro Lys Thr Gly Glu Glu Val Pro Thr Gly Glu Ala Gly Glu

345 350 355gtt ctc atc cgc gga cca cat gtg atg acc gga tac tgg aac cga cca 1219Val Leu Ile Arg Gly Pro His Val Met Thr Gly Tyr Trp Asn Arg Pro

360 365 370gaa gac acc gcc agc gca cta caa aat ggc tgg tac cac tcc gga gat 1267Glu Asp Thr Ala Ser Ala Leu Gln Asn Gly Trp Tyr His Ser Gly Asp

375 380 385atc gcc atc aaa gat gaa gac ggc tac tac acc atc aaa gac cgc atc 1315Ile Ala Ile Lys Asp Glu Asp Gly Tyr Tyr Thr Ile Lys Asp Arg Ile390 395 400 405aaa gac atg tac atc tcc ggc ggc gaa aac att tac ccc gca gaa gtc 1363Lys Asp Met Tyr Ile Ser Gly Gly Glu Asn Ile Tyr Pro Ala Glu Val

410415420 taagtaccc1372<210>88<211>421<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>88Met Lys Val Asn Leu Gly Ile Gly Ser Tyr Pro Arg Arg Arg Ala Thr 151015 Val Arg Pro Glu Ser Thr Ala Ile Glu Phe Glu Gly Thr Ser Ile Thr

20 25 30Tyr Gly Glu Phe Ser Lys Arg Val Asn Arg Leu Gly His Ala Leu Leu

35 40 45Asp Leu Gly Val Ala His Gln Asp Arg Val Ala Tyr Val Gly Phe Asn

50 55 60His Pro Ala Leu Leu Glu Val Phe Phe Ser Thr Asn Leu Ile Gly Ala 65 70 75 80Thr Pro Val Leu Val Asn Pro Arg Leu Ser Ala Asn Glu Ile Asp Tyr

85 90 95Ile Ile Gln Asp Ser Gly Ala Ser Ile Val Phe Tyr Gly Ile Asp Leu

100 105 110Ile Glu His Ala Thr Tyr Leu Gln Glu Leu His Pro Glu Ile Ile Met

115 120 125Val Ala Val Glu Gly Asp Glu Gly Pro Gly Leu Arg Arg Lys Ala Leu

130 135 140Ile Glu Ala Ala Ser Asp Ala Asp Ile Asp Leu Glu Val Ser Asp Asp145 150 155 160Asp Leu Val Leu Leu Met Tyr Thr Ser Gly Thr Thr Gly Arg Pro Lys

165 170 175Gly Ala Met Leu Ser His Arg Asn Leu Phe Phe Asn Tyr Phe Asn Ala

180 185 190Leu Leu Ser Gln Glu Ile Glu Gln Gly Ala Val Leu Leu Ser Thr Ala

195 200 205Pro Leu Phe His Ile Ala Gly Leu Asn Met Thr Thr Ile Pro Val Met

210 215 220Met Lys Gly Gly Lys Val Ile Ile His Arg Glu Phe Arg Ala Glu His225 230 235 240Val Leu Asp Glu Ile Glu Arg Ser Lys Val Ser Glu Ser Phe Met Val

245 250 255Pro Ala Met Ile Asp Met Leu Ser Asn His Pro Ser Phe Ala Glu Arg

260 265 270Asp Leu Ser Ser Leu Arg Ala Ile Met Val Gly Gly Ser Pro Leu Ser

275 280 285Glu Arg Ala Leu Arg Ile Trp Gln Gly Arg Asp Val Lys Ile Val Gln

290 295 300Gly Phe Gly Met Thr Glu Thr Ala Pro Gly Ala Cys Ile Leu Glu Ala305 310 315 320Thr Asp Thr Ser Thr His LeuGly Thr Ala Gly Arg Ala His Phe Phe

325 330 335Thr Asp Ile Lys Leu Val Asp Pro Lys Thr Gly Glu Glu Val Pro Thr

340 345 350Gly Glu Ala Gly Glu Val Leu Ile Arg Gly Pro His Val Met Thr Gly

355 360 365Tyr Trp Asn Arg Pro Glu Asp Thr Ala Ser Ala Leu Gln Asn Gly Trp

370 375 380Tyr His Ser Gly Asp Ile Ala Ile Lys Asp Glu Asp Gly Tyr Tyr Thr385 390 395 400Ile Lys Asp Arg Ile Lys Asp Met Tyr Ile Ser Gly Gly Glu Asn Ile

405 410 415Tyr Pro Ala Glu Val

420<210>89<211>867<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (844)<223>RXA00681<400>89aagggcaagg ttgtcattgt tgatccagat gcgccacgca tcgaaggacc cggcgcgcac 60agccatgcgc actcagtagc agcacatggg gtggatacac atg cct agt cca cgc 115

Met Pro Ser Pro Arg

1 5act gtt ctt atc act ggt gcc gct ggc ggt ttg ggt cgg gca ttc gct 163Thr Val Leu Ile Thr Gly Ala Ala Gly Gly Leu Gly Arg Ala Phe Ala

10 15 20gaa ggt ttc gca gcc caa gga gac cgt atc gcg gtg gcg gat atc aat 211Glu Gly Phe Ala Ala Gln Gly Asp Arg Ile Ala Val Ala Asp Ile Asn

25 30 35ctg gat ggg gcg caa gag acc gtt gac aag ctg aaa gca ttg ggc gca 259Leu Asp Gly Ala Gln Glu Thr Val Asp Lys Leu Lys Ala Leu Gly Ala

40 45 50gat gcc gca gcc ttt gaa gtt gat gtc acg tct ttg gag tcc acc gag 307Asp Ala Ala Ala Phe Glu Val Asp Val Thr Ser Leu Glu Ser Thr Glu

55 60 65gcc cta gcc gcc ggt gcc gct gag ttt ggc ggt ggc cga att gat gtc 355Ala Leu Ala Ala Gly Ala Ala Glu Phe Gly Gly Gly Arg Ile Asp Val 70 75 80 85ctt att aat aac gca gcg ata tat gcg aca gtg act cgt tca ccg ttt 403Leu Ile Asn Asn Ala Ala Ile Tyr Ala Thr Val Thr Arg Ser Pro Phe

90 95 100gag gat att gac cct gcg gag tgg gat ttg gtc atg gga gtc aat ctc 451Glu Asp Ile Asp Pro Ala Glu Trp Asp Leu Val Met Gly Val Asn Leu

105 110 115aaa ggc ccg tgg ttg gtg acg cgt tct gtg agt ccg ttt ttg tcc gat 499Lys Gly Pro Trp Leu Val Thr Arg Ser Val Ser Pro Phe Leu Ser Asp

120 125 130aat gcc cgt gtg gtc aat ctt tcc agc gcg act gtg ttt tca gga tct 547Asn Ala Arg Val Val Asn Leu Ser Ser Ala Thr Val Phe Ser Gly Ser

135 140 145gca cac tgg gcg cac tac gtg gca tcc aaa ggt ggg gtc att gct tta 595Ala His Trp Ala His Tyr Val Ala Ser Lys Gly Gly Val Ile Ala Leu150 155 160 165acc agg gtg ctt gct aaa gag ctg ggt ggt cgt ggg atc acg gtc aat 643Thr Arg Val Leu Ala Lys Glu Leu Gly Gly Arg Gly Ile Thr Val Asn

170 175 180gcg gtt gcg cct ggg ttt acg ctg act gaa gcc agc ttg gga ctc atg 691Ala Val Ala Pro Gly Phe Thr Leu Thr Glu Ala Ser Leu Gly Leu Met

185 190 195gat agc gcg gaa acg tac ggt gtc gat cgc gga tcc atc aag cgc gca 739Asp Ser Ala Glu Thr Tyr Gly Val Asp Arg Gly Ser Ile Lys Arg Ala

200 205 210agc caa ccg aaa gac atc gtc ggc acc acc atg ttt ctt gca tcc cca 787Ser Gln Pro Lys Asp Ile Val Gly Thr Thr Met Phe Leu Ala Ser Pro

215220225 gaa gcc gaa tac atc act ggg caa aca ctc atc gtt gat ggt ggc cga 835Glu Ala Glu Tyr Ile Thr Gly Gln Thr Leu Ile Val Asp Gly Gly Arg 230235240245 cag ttc atc taagtactaa aagttctaag gag 867Gln Phe Ile<210>90<211>248<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>90Met Pro Ser Pro Arg Thr Val Leu Ile Thr Gly Ala Ala Gly Gly Leu 151015 Gly Arg Ala Phe Ala Glu Gly Phe Ala Ala Gln Gly Asp Arg Ile Ala

20 25 30Val Ala Asp Ile Asn Leu Asp Gly Ala Gln Glu Thr Val Asp Lys Leu

35 40 45Lys Ala Leu Gly Ala Asp Ala Ala Ala Phe Glu Val Asp Val Thr Ser

50 55 60Leu Glu Ser Thr Glu Ala Leu Ala Ala Gly Ala Ala Glu Phe Gly Gly 65 70 75 80Gly Arg Ile Asp Val Leu Ile Asn Asn Ala Ala Ile Tyr Ala Thr Val

85 90 95Thr Arg Ser Pro Phe Glu Asp Ile Asp Pro Ala Glu Trp Asp Leu Val

100 105 110Met Gly Val Asn Leu Lys Gly Pro Trp Leu Val Thr Arg Ser Val Ser

115 120 125Pro Phe Leu Ser Asp Asn Ala Arg Val Val Asn Leu Ser Ser Ala Thr

130 135 140Val Phe Ser Gly Ser Ala His Trp Ala His Tyr Val Ala Ser Lys Gly145 150 155 160Gly Val Ile Ala Leu Thr Arg Val LeuAla Lys Glu Leu Gly Gly Arg

165 170 175Gly Ile Thr Val Asn Ala Val Ala Pro Gly Phe Thr Leu Thr Glu Ala

180 185 190Ser Leu Gly Leu Met Asp Ser Ala Glu Thr Tyr Gly Val Asp Arg Gly

195 200 205Ser Ile Lys Arg Ala Ser Gln Pro Lys Asp Ile Val Gly Thr Thr Met

210 215 220Phe Leu Ala Ser Pro Glu Ala Glu Tyr Ile Thr Gly Gln Thr Leu Ile225 230 235 240Val Asp Gly Gly Arg Gln Phe Ile

245<210>91<211>837<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (814)<223>RXA00802<400>91gccatggtga tcacaccagt gtgggggctg aggctccaca cttggaggaa tggattaaac 60gcgggcacta agccccgaac gattagtagg cttgggcacc atg gat ctt aaa ctt 115

Met Asp Leu Lys Leu

1 5ggt ggc caa gtc ata ctt gtt gtt ggc ggt gca gga act att ggt tct 163Gly Gly Gln Val Ile Leu Val Val Gly Gly Ala Gly Thr Ile Gly Ser

10 15 20gaa gtt gta aaa ctc tta act gaa gaa ggc gca acc gcg gta gcg gcg 211Glu Val Val Lys Leu Leu Thr Glu Glu Gly Ala Thr Ala Val Ala Ala

25 30 35tcg aga agc acg ccc tta tct att gac gct tcg gat gaa gcg tcc gtc 259Ser Arg Ser Thr Pro Leu Ser Ile Asp Ala Ser Asp Glu Ala Ser Val

40 45 50cgt gcg ggc att gat cag gtg atc gca gaa cat ggt cgc ctg gat ggg 307Arg Ala Gly Ile AspGln Val Ile Ala Glu His Gly Arg Leu Asp Gly

55 60 65ctg gtt gtt tct tct gca ccc gct gcg caa acg ctc agc gcg gag aca 355Leu Val Val Ser Ser Ala Pro Ala Ala Gln Thr Leu Ser Ala Glu Thr 70 75 80 85gca gat gat ccg gac act gtg ttg gct gct att gaa ggc aaa gcc atc 403Ala Asp Asp Pro Asp Thr Val Leu Ala Ala Ile Glu Gly Lys Ala Ile

90 95 100acg ttt atg aag gct gca acc gtg gcg ctc gag aag atg cgt gag gct 451Thr Phe Met Lys Ala Ala Thr Val Ala Leu Glu Lys Met Arg Glu Ala

105 110 115gga cat ggg cgc atc gtt gca ctt tcc ggc atg aac tca tac aaa aca 499Gly His Gly Arg Ile Val Ala Leu Ser Gly Met Asn Ser Tyr Lys Thr

120 125 130ttg agt act act gcg tcg gcg cga aat gct gcg ctg aat gtc gtg gtg 547Leu Ser Thr Thr Ala Ser Ala Arg Asn Ala Ala Leu Asn Val Val Val

135 140 145aaa aat ttg gcg gat cgt cac gcg ggc acc gga att aca gta aat gcg 595Lys Asn Leu Ala Asp Arg His Ala Gly Thr Gly Ile Thr Val Asn Ala150 155 160 165att agc ccg gga ttc gtg gta gct gag cca gac gct gag gta aac cgc 643Ile Ser Pro Gly Phe Val Val Ala Glu Pro Asp Ala Glu Val Asn Arg

170 175 180gca aat ggt gac acc acg tgg agg agg tcg cgg agg cga tcg cgt ttt 691Ala Asn Gly Asp Thr Thr Trp Arg Arg Ser Arg Arg Arg Ser Arg Phe

185 190 195tgt tgt cgc cgc gca ccg cat caa ttt ctg gag aga tta ttt cgg tgg 739Cys Cys Arg Arg Ala Pro His Gln Phe Leu Glu Arg Leu Phe Arg Trp

200 205210gac ata agg cga agg gca tca tcc ttc ctt agc tcg cgt gag ctt ccc 787Asp Ile Arg Arg Arg Ala Ser Ser Phe Leu Ser Ser Arg Glu Leu Pro

215220225 aag cgt aag cac ccc cgt gtg agg gca taacggccgt tctgttaaag 834Lys Arg Lys His Pro Arg Val Arg Ala 230235 att 837<210>92<211>238<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>92Met Asp Leu Lys Leu Gly Gly Gln Val Ile Leu Val Val Gly Gly Ala 151015 Gly Thr Ile Gly Ser Glu Val Val Lys Leu Leu Thr Glu Glu Gly Ala

20 25 30Thr Ala Val Ala Ala Ser Arg Ser Thr Pro Leu Ser Ile Asp Ala Ser

35 40 45Asp Glu Ala Ser Val Arg Ala Gly Ile Asp Gln Val Ile Ala Glu His

50 55 60Gly Arg Leu Asp Gly Leu Val Val Ser Ser Ala Pro Ala Ala Gln Thr 65 70 75 80Leu Ser Ala Glu Thr Ala Asp Asp Pro Asp Thr Val Leu Ala Ala Ile

85 90 95Glu Gly Lys Ala Ile Thr Phe Met Lys Ala Ala Thr Val Ala Leu Glu

100 105 110Lys Met Arg Glu Ala Gly His Gly Arg Ile Val Ala Leu Ser Gly Met

115 120 125Asn Ser Tyr Lys Thr Leu Ser Thr Thr Ala Ser Ala Arg Asn Ala Ala

130 135 140Leu Asn Val Val Val Lys Asn Leu Ala Asp Arg His Ala Gly Thr Gly145 150 155 160Ile Thr Val Asn Ala Ile Ser Pro Gly Phe Val Val Ala Glu Pro Asp

165 170 175Ala Glu Val Asn Arg Ala Asn Gly Asp Thr Thr Trp Arg Arg Ser Arg

180 185 190Arg Arg Ser Arg Phe Cys Cys Arg Arg Ala Pro His Gln Phe Leu Glu

195 200 205Arg Leu Phe Arg Trp Asp Ile Arg Arg Arg Ala Ser Ser Phe Leu Ser

210215220 Ser Arg Glu Leu Pro Lys Arg Lys His Pro Arg Val Arg Ala 225230235<210>93<211>329<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1).<306><223>RXA02133<400>93gaa aac ccc tac att ggc gga gct gga tac aac gca gca aaa ttc ggt 48Glu Asn Pro Tyr Ile Gly Gly Ala Gly Tyr Asn Ala Ala Lys Phe Gly 151015 gta gca gca ttc aac cgt gtg ctt cgc ttg gaa acc cac cag cag acc 96Val Ala Ala Phe Asn Arg Val Leu Arg Leu Glu Thr His Gln Gln Thr<400>93 Glu Asn Pro Tyr Ile Gly Gly Ala Gly Tyr Asn Ala Ala Lys Phe Gly 015 gta gca gca ttc aac cgt gtg ctt cgc ttg gaa acc cac cag cag acc

20 25 30ctt cgc gta tct gag atc gat cca ggt cga gtt gcc acg gaa gaa ttc 144Leu Arg Val Ser Glu Ile Asp Pro Gly Arg Val Ala Thr Glu Glu Phe

35 40 45tcc ctc gtt cgt ttc ggc gga gat aaa gaa cgc gca gaa gca gtc tat 192Ser Leu Val Arg Phe Gly Gly Asp Lys Glu Arg Ala Glu Ala Val Tyr

50 55 60gac gac gtc ctc aac ctc acc get gaa gac atc gca gag tct gtg cgt 240Asp Asp Val Leu Asn Leu Thr Ala Glu Asp Ile Ala Glu Ser Val Arg 65 70 75 80tgg gtc gcg agc ctt cca aag cac atg aac att gac cgc atg cgt att 288Trp Val Ala Ser Leu Pro Lys His Met Asn Ile Asp Arg Met Arg Ile

85 90 95aca cct cgc gat cag gtc taaaacccgc actcttttga aat 329Thr Pro Arg Asp Gln Val

100<210>94<211>102<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>94Glu Asn Pro Tyr Ile Gly Gly Ala Gly Tyr Asn Ala Ala Lys Phe Gly 151015 Val Ala Ala Phe Asn Arg Val Leu Arg Leu Glu Thr His Gln Gln Thr

20 25 30Leu Arg Val Ser Glu Ile Asp Pro Gly Arg Val Ala Thr Glu Glu Phe

35 40 45Ser Leu Val Arg Phe Gly Gly Asp Lys Glu Arg Ala Glu Ala Val Tyr

50 55 60Asp Asp Val Leu Asn Leu Thr Ala Glu Asp Ile Ala Glu Ser Val Arg 65 70 75 80Trp Val Ala Ser Leu Pro Lys His Met Asn Ile Asp Arg Met Arg Ile

85 90 95Thr Pro Arg Asp Gln Val

100<210>95<211>1347<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1324)<223>RXN01114<400>95ttcggtggaa gatatccgca agctggtgct gccgcagctt ttagaaacgg ctcaagcaat 60ttcgacagat ctctctgcac tctaaattaa ggatcaaaaa atg aac cct caa gat 115

Met Asn Pro Gln Asp

1 5att gtc atc tgt tcc cca ttg cgc acc cca gtt ggt gct tac ggc gga 163Ile Val Ile Cys Ser Pro Leu Arg Thr Pro Val Gly Ala Tyr Gly Gly

10 15 20tcc ttc acc ggc gtc cct gtt gaa gaa ttg gcc acc acc gtg atc aac 211Ser Phe Thr Gly Val Pro Val Glu Glu Leu Ala Thr Thr Val Ile Asn

25 30 35gcg atc gtt gag gca acc ggc atc accggc gac gat gtg gac gat ctg 259Ala Ile Val Glu Ala Thr Gly Ile Thr Gly Asp Asp Val Asp Asp Leu

40 45 50atc ctc ggc cag gca tcc ccc aac ggt gcg gct cca gca ctg ggc cgt 307Ile Leu Gly Gln Ala Ser Pro Asn Gly Ala Ala Pro Ala Leu Gly Arg

55 60 65gtt gtt gct cta gat tcc aag ctt ggc caa aac gtt cca ggc atg cag 355Val Val Ala Leu Asp Ser Lys Leu Gly Gln Asn Val Pro Gly Met Gln 70 75 80 85ctt gat cgc cgc tgt ggt tcc ggc ctg cag gca atc gtc acc gct gct 403Leu Asp Arg Arg Cys Gly Ser Gly Leu Gln Ala Ile Val Thr Ala Ala

90 95 100gca cac gtt gca tcc ggc gct gct gat ctg atc atc gca ggt ggc gca 451Ala His Val Ala Ser Gly Ala Ala Asp Leu Ile Ile Ala Gly Gly Ala

105 110 115gaa tcc atg agc cgc gtt gag tac acc gtg tcc ggc gat atc cgt tgg 499Glu Ser Met Ser Arg Val Glu Tyr Thr Val Ser Gly Asp Ile Arg Trp

120 125 130ggt gtc aag ggc ggc gac atg cag ctt cgt gac cgc ctt gca gaa gca 547Gly Val Lys Gly Gly Asp Met Gln Leu Arg Asp Arg Leu Ala Glu Ala

135 140 145cgc gaa acc gct ggc gga cgc aac cac ccg atc cct ggt ggc atg atc 595Arg Glu Thr Ala Gly Gly Arg Asn His Pro Ile Pro Gly Gly Met Ile150 155 160 165gag acc gct gag aac ctg cgt cgc gaa tac ggc atc tcc cgc gag gag 643Glu Thr Ala Glu Asn Leu Arg Arg Glu Tyr Gly Ile Ser Arg Glu Glu

170 175 180cag gac aag atc tcc gca gcg tcc cag cag cgt tgg ggc aag gct gct 691Gln Asp Lys Ile Ser Ala Ala Ser Gln Gln Arg Trp Gly Lys Ala Ala

185 190 195gat gcg ggg ctt ttc gac gac gag atc gtg cca gtc acc gtc cct gcc 739Asp Ala Gly Leu Phe Asp Asp Glu Ile Val Pro Val Thr Val Pro Ala

200 205 210aag aag cgc ggc cag gag cca acc atc gtt tct cga gac gag cat ggt 787Lys Lys Arg Gly Gln Glu Pro Thr Ile Val Ser Arg Asp Glu His Gly

215 220 225cga cca gga aca acc gtc gaa aag ctt gct gct ttg cgc ccc atc atg 835Arg Pro Gly Thr Thr Val Glu Lys Leu Ala Ala Leu Arg Pro Ile Met230 235 240 245ggc cgc cag gat gcg gaa gca acc gtc acc gct ggc aac gcg tcc ggc 883Gly Arg Gln Asp Ala Glu Ala Thr Val Thr Ala Gly Asn Ala Ser Gly

250 255 260caa aat gat ggc gct gct gcc gtc atc gtg acc act cgc gcc aag gcc 931Gln Asn Asp Gly Ala Ala Ala Val Ile Val Thr Thr Arg Ala Lys Ala

265 270 275gag gag aag ggc ctg cgc cca gtc atg cgt ttg gct ggc tgg tct gtg 979Glu Glu Lys Gly Leu Arg Pro Val Met Arg Leu Ala Gly Trp Ser Val

280 285 290gct gct gtt ccc cca gag acc atg ggt att gga cct gtt cct gcc acc 1027Ala Ala Val Pro Pro Glu Thr Met Gly Ile Gly Pro Val Pro Ala Thr

295 300 305aag aag gtc ctg gat cgt ttg ggc ctt acc ctg gag gac atc ggc gcg 1075Lys Lys Val Leu Asp Arg Leu Gly Leu Thr Leu Glu Asp Ile Gly Ala310 315 320 325atc gaa ctc aac gaa gct ttc gca gct cag gca ctg tct gtg ctg aag 1123Ile Glu Leu Asn Glu Ala Phe Ala Ala Gln Ala Leu Ser Val Leu Lys

330 335 340gaa tgg aac att tct tgg gaa gat gag cgc gtc aac cca ctg ggt tcc 1171Glu Trp Asn Ile Ser Trp Glu Asp Glu Arg Val Asn Pro Leu Gly Ser

345 350 355ggt att tcc atg gga cac cca gtc ggt gcc acc ggt gct cgc atg gca 1219Gly Ile Ser Met Gly His Pro Val Gly Ala Thr Gly Ala Arg Met Ala

360 365 370gta acc ttg gct cac cgc atg cag cgt gaa aac act cag tac gga ctg 1267Val Thr Leu Ala His Arg Met Gln Arg Glu Asn Thr Gln Tyr Gly Leu

375380385 gcc acc atg tgc atc ggt ggc ggc cag ggt ctt gca gct gtc ttt gaa 1315Ala Thr Met Cys Ile Gly Gly Gly Gln Gly Leu Ala Ala Val Phe Glu 390395400405 aag gag aac taaaaatggc tattttgcac agc 1347Lys Glu Asn<210>96<211>408<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>96Met Asn Pro Gln Asp Ile Val Ile Cys Ser Pro Leu Arg Thr Pro Val 151015 Gly Ala Tyr Gly Gly Ser Phe Thr Gly Val Pro Val Glu Glu Leu Ala

20 25 30Thr Thr Val Ile Asn Ala Ile Val Glu Ala Thr Gly Ile Thr Gly Asp

35 40 45Asp Val Asp Asp Leu Ile Leu Gly Gln Ala Ser Pro Asn Gly Ala Ala

50 55 60Pro Ala Leu Gly Arg Val Val Ala Leu Asp Ser Lys Leu Gly Gln Asn 65 70 75 80Val Pro Gly Met Gln Leu Asp Arg Arg Cys Gly Ser Gly Leu Gln Ala

85 90 95Ile Val Thr Ala Ala Ala His Val Ala Ser Gly Ala Ala Asp Leu Ile

100 105 110Ile Ala Gly Gly Ala Glu Ser Met Ser Arg Val Glu Tyr Thr Val Ser

115 120 125Gly Asp Ile Arg Trp Gly Val Lys Gly Gly Asp Met Gln Leu Arg Asp

130 135 140Arg Leu Ala Glu Ala Arg Glu Thr Ala Gly Gly Arg Asn His Pro Ile145 150 155 160Pro Gly Gly Met Ile Glu Thr Ala Glu Asn Leu Arg Arg Glu Tyr Gly

165 170 175Ile Ser Arg Glu Glu Gln Asp Lys Ile Ser Ala Ala Ser Gln Gln Arg

180 185 190Trp Gly Lys Ala Ala Asp Ala Gly Leu Phe Asp Asp Glu Ile Val Pro

195 200 205Val Thr Val Pro Ala Lys Lys Arg Gly Gln Glu Pro Thr Ile Val Ser

210 215 220Arg Asp Glu His Gly Arg Pro Gly Thr Thr Val Glu Lys Leu Ala Ala225 230 235 240Leu Arg Pro Ile Met Gly Arg Gln Asp Ala Glu Ala Thr Val Thr Ala

245 250 255Gly Asn Ala Ser Gly Gln Asn Asp Gly Ala Ala Ala Val Ile Val Thr

260 265 270Thr Arg Ala Lys Ala Glu Glu Lys Gly Leu Arg Pro Val Met Arg Leu

275 280 285Ala Gly Trp Ser Val Ala Ala Val Pro Pro Glu Thr Met Gly Ile Gly

290 295 300Pro Val Pro Ala Thr Lys Lys Val Leu Asp Arg Leu Gly Leu Thr Leu305 310 315 320Glu Asp Ile Gly Ala Ile Glu Leu Asn Glu Ala Phe Ala Ala Gln Ala

325 330 335Leu Ser Val Leu Lys Glu Trp Asn Ile Ser Trp Glu Asp Glu Arg Val

340 345 350Asn Pro Leu Gly Ser Gly Ile Ser Met Gly His Pro Val Gly Ala Thr

355 360 365Gly Ala Arg Met Ala Val Thr Leu Ala His Arg Met Gln Arg Glu Asn

370 375 380Thr Gln Tyr Gly Leu Ala Thr Met Cys Ile Gly Gly Gly Gln Gly Leu385 390 395 400Ala Ala Val Phe Glu Lys Glu Asn

405<210>97<211>815<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (792)<223>FRXA01114<400>97cgc ctt gca gaa gca cgc gaa acc gct ggc gga cgc aac cac ccg atc 48Arg Leu Ala Glu Ala Arg Glu Thr Ala Gly Gly Arg Asn His Pro Ile 151015 cct ggt ggc atg atc gag acc gct gag aac ctg cgt cgc gaa tac ggc 96Pro Gly Gly Met Ile Glu Thr Ala Glu Asn Leu Arg Arg Glu Tyr Gly

20 25 30atc tcc cgc gag gag cag gac aag atc tcc gca gcg tcc cag cag cgt 144Ile Ser Arg Glu Glu Gln Asp Lys Ile Ser Ala Ala Ser Gln Gln Arg

35 40 45tgg ggc aag gct gct gat gcg ggg ctt ttc gac gac gag atc gtg cca 192Trp Gly Lys Ala Ala Asp Ala Gly Leu Phe Asp Asp Glu Ile Val Pro

50 55 60gtc acc gtc cct gcc aag aag cgc ggc cag gag cca acc atc gtt tct 240Val Thr Val Pro Ala Lys Lys Arg Gly Gln Glu Pro Thr Ile Val Ser 65 70 75 80cga gac gag cat ggt cga cca gga aca acc gtc gaa aag ctt gct gct 288Arg Asp Glu His Gly Arg Pro Gly Thr Thr Val Glu Lys Leu Ala Ala

85 90 95ttg cgc ccc atc atg ggc cgc cag gat gcg gaa gca acc gtc acc gct 336Leu Arg Pro Ile Met Gly Arg Gln Asp Ala Glu Ala Thr Val Thr Ala

100 105 110ggc aac gcg tcc ggc caa aat gat ggc gct gct gcc gtc atc gtg acc 384Gly Asn Ala Ser Gly Gln Asn Asp Gly Ala Ala Ala Val Ile Val Thr

115 120 125act cgc gcc aag gcc gag gag aag ggc ctg cgc cca gtc atg cgt ttg 432Thr Arg Ala Lys Ala Glu Glu Lys Gly Leu Arg Pro Val Met Arg Leu

130 135 140gct ggc tgg tct gtg gct gct gtt ccc cca gag acc atg ggt att gga 480Ala Gly Trp Ser Val Ala Ala Val Pro Pro Glu Thr Met Gly Ile Gly

145 150 155 160cct gtt cct gcc acc aag aag gtc ctg gat cgt ttg ggc ctt acc ctg 528Pro Val Pro Ala Thr Lys Lys Val Leu Asp Arg Leu Gly Leu Thr Leu

165 170 175gag gac atc ggc gcg atc gaa ctc aac gaa gct ttc gca gct cag gca 576Glu Asp Ile Gly Ala Ile Glu Leu Asn Glu Ala Phc Ala Ala Gln Ala

180 185 190ctg tct gtg ctg aag gaa tgg aac att tct tgg gaa gat gag cgc gtc 624Leu Ser Val Leu Lys Glu Trp Asn Ile Ser Trp Glu Asp Glu Arg Val

195 200 205aac cca ctg ggt tcc ggt att tcc atg gga cac cca gtc ggt gcc acc 672Asn Pro Leu Gly Ser Gly Ile Ser Met Gly His Pro Val Gly Ala Thr

210 215 220ggt gct cgc atg gca gta acc ttg gct cac cgc atg cag cgt gaa aac 720Gly Ala Arg Met Ala Val Thr Leu Ala His Arg Met Gln Arg Glu Asn

225 230 235 240act cag tac gga ctg gcc acc atg tgc atc ggt ggc ggc cag ggt ctt 768Thr Gln Tyr Gly Leu Ala Thr Met Cys Ile Gly Gly Gly Gln Gly Leu

245 250 255gca gct gtc ttt gaa aag gag aac taaaaatggc tattttgcacagc 815Ala Ala Val Phe Glu Lys Glu Asn

260<210>98<211>264<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>98Arg Leu Ala Glu Ala Arg Glu Thr Ala Gly Gly Arg Asn His Pro Ile 151015 Pro Gly Gly Met Ile Glu Thr Ala Glu Asn Leu Arg Arg Glu Tyr Gly

20 25 30Ile Ser Arg Glu Glu Gln Asp Lys Ile Ser Ala Ala Ser Gln Gln Arg

35 40 45Trp Gly Lys Ala Ala Asp Ala Gly Leu Phe Asp Asp Glu Ile Val Pro

50 55 60Val Thr Val Pro Ala Lys Lys Arg Gly Gln Glu Pro Thr Ile Val Ser 65 70 75 80Arg Asp Glu His Gly Arg Pro Gly Thr Thr Val Glu Lys Leu Ala Ala

85 90 95Leu Arg Pro Ile Met Gly Arg Gln Asp Ala Glu Ala Thr Val Thr Ala

100 105 110Gly Asn Ala Ser Gly Gln Asn Asp Gly Ala Ala Ala Val Ile Val Thr

115 120 125Thr Arg Ala Lys Ala Glu Glu Lys Gly Leu Arg Pro Val Met Arg Leu

130 135 140Ala Gly Trp Ser Val Ala Ala Val Pro Pro Glu Thr Met Gly Ile Gly145 150 155 160Pro Val Pro Ala Thr Lys Lys Val Leu Asp Arg Leu Gly Leu Thr Leu

165 170 175Glu Asp Ile Gly Ala Ile Glu Leu Asn Glu Ala Phe Ala Ala Gln Ala

180 185 190Leu Ser Val Leu Lys Glu Trp Asn Ile Ser Trp Glu Asp Glu Arg Val

195 200 205Asn Pro LeuGly Ser Gly Ile Ser Met Gly His Pro Val Gly Ala Thr

210 215 220Gly Ala Arg Met Ala Val Thr Leu Ala His Arg Met Gln Arg Glu Asn225 230 235 240Thr Gln Tyr Gly Leu Ala Thr Met Cys Ile Gly Gly Gly Gln Gly Leu

245 250 255Ala Ala Val Phe Glu Lys Glu Asn

260<210>99<211>978<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (955)<223>RXA01894<400>99agaatttttt cgaaaatgct ggcaccatca acagtgacat tgttagaaac ttcaaggaga 60acccatgaat gaaccggagc aacatcaccg gtccatgagg atg ccc aaa ccc aaa 115

Met Pro Lys Pro Lys

1 5aat aat gcg ggt cga gat ctc aaa gct gcc att gct gtg ggg atc gga 163Asn Asn Ala Gly Arg Asp Leu Lys Ala Ala Ile Ala Val Gly Ile Gly

10 15 20ctg ggg gtc ctg gtt ctt ttg ggg att gtc cta agc cca tgg ggt tgg 211Leu Gly Val Leu Val Leu Leu Gly Ile Val Leu Ser Pro Trp Gly Trp

25 30 35tac atc ctc gtt gca ggt ttt atg gct gca gca aca tgg gaa gtt ggt 259Tyr Ile Leu Val Ala Gly Phe Met Ala Ala Ala Thr Trp Glu Val Gly

40 45 50agc aga ctt aaa gaa ggc ggc tat cat ttg cca ctg ccg att atg atc 307Ser Arg Leu Lys Glu Gly Gly Tyr His Leu Pro Leu Pro Ile Met Ile

55 60 65atc ggc ggt cag gca atc atc tgg ctg tca tgg cca ttt ggc acg atg 355Ile Gly Gly Gln Ala Ile Ile Trp Leu Ser Trp Pro Phe Gly Thr Met 7075 80 85ggc att ttg gcg tct ttt gtg gcc act gtg ttg gtg ctg atg tat ttc 403Gly Ile Leu Ala Ser Phe Val Ala Thr Val Leu Val Leu Met Tyr Phe

90 95 100cga att ttc tac aat ggc acg gaa aaa gaa gcc cgc aac tat ttg agg 451Arg Ile Phe Tyr Asn Gly Thr Glu Lys Glu Ala Arg Asn Tyr Leu Arg

105 110 115gac acc tct gtg ggc atc ttc gtg ctc acc tgg att cca ttg ttc gga 499Asp Thr Ser Val Gly Ile Phe Val Leu Thr Trp Ile Pro Leu Phe Gly

120 125 130agc ttc gct gcg atg ctg tcg ctg atg caa aac aat tcc atc ccg ggt 547Ser Phe Ala Ala Met Leu Ser Leu Met Gln Asn Asn Ser Ile Pro Gly

135 140 145aca tat ttc att ttg acg ttc atg ctg tgt gtg atc gca tcg gat gtg 595Thr Tyr Phe Ile Leu Thr Phe Met Leu Cys Val Ile Ala Ser Asp Val150 155 160 165ggc ggg tat atc gcg ggt gtg ttc ttt gga tcg cac cca atg gcg ccg 643Gly Gly Tyr Ile Ala Gly Val Phe Phe Gly Ser His Pro Met Ala Pro

170 175 180ttg gtg agt ccg aag aag tct tgg gaa ggc ttt gcc ggc tcc att gtc 691Leu Val Ser Pro Lys Lys Ser Trp Glu Gly Phe Ala Gly Ser Ile Val

185 190 195tta gga tcg gtc act ggt gca ctc agt gtt cac ttc ctg ctc gat cac 739Leu Gly Ser Val Thr Gly Ala Leu Ser Val His Phe Leu Leu Asp His

200 205 210cac tgg tgg atg ggt gtg atc ttg ggt tgt gcc cta gtt gtg tgc gcc 787His Trp Trp Met Gly Val Ile Leu Gly Cys Ala Leu Val Val Cys Ala

215 220 225acg ttg ggt gac ttg gtt gag tcg cag ttc aaa cgc gatttg ggc atc 835Thr Leu Gly Asp Leu Val Glu Ser Gln Phe Lys Arg Asp Leu Gly Ile230 235 240 245aag gat atg tcg aac ctt ctt cca ggc cac ggc gga ttg atg gac cgt 883Lys Asp Met Ser Asn Leu Leu Pro Gly His Gly Gly Leu Met Asp Arg

250 255 260ttg gat ggc atg ctc ccg gcc gcg atg gtg acg tgg ttg atc ctg agt 931Leu Asp Gly Met Leu Pro Ala Ala Met Val Thr Trp Leu Ile Leu Ser

265 270 275gtg atc agc agc tcg tat ccg tcg taaagcttgg gccagcttta agt 978Val Ile Ser Ser Ser Tyr Pro Ser

280285<210>100<211>285<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>100Met Pro Lys Pro Lys Asn Asn Ala Gly Arg Asp Leu Lys Ala Ala Ile 151015 Ala Val Gly Ile Gly Leu Gly Val Leu Val Leu Leu Gly Ile Val Leu

20 25 30Ser Pro Trp Gly Trp Tyr Ile Leu Val Ala Gly Phe Met Ala Ala Ala

35 40 45Thr Trp Glu Val Gly Ser Arg Leu Lys Glu Gly Gly Tyr His Leu Pro

50 55 60Leu Pro Ile Met Ile Ile Gly Gly Gln Ala Ile Ile Trp Leu Ser Trp 65 70 75 80Pro Phe Gly Thr Met Gly Ile Leu Ala Ser Phe Val Ala Thr Val Leu

85 90 95Val Leu Met Tyr Phe Arg Ile Phe Tyr Asn Gly Thr Glu Lys Glu Ala

100 105 110Arg Asn Tyr Leu Arg Asp Thr Ser Val Gly Ile Phe Val Leu Thr Trp

115 120 125Ile Pro Leu Phe Gly Ser Phe Ala Ala Met Leu Ser Leu Met Gln Asn

130 135 140Asn Ser Ile Pro Gly Thr Tyr Phe Ile Leu Thr Phe Met Leu Cys Val145 150 155 160Ile Ala Ser Asp Val Gly Gly Tyr Ile Ala Gly Val Phe Phe Gly Ser

165 170 175His Pro Met Ala Pro Leu Val Ser Pro Lys Lys Ser Trp Glu Gly Phe

180 185 190Ala Gly Ser Ile Val Leu Gly Ser Val Thr Gly Ala Leu Ser Val His

195 200 205Phe Leu Leu Asp His His Trp Trp Met Gly Val Ile Leu Gly Cys Ala

210 215 220Leu Val Val Cys Ala Thr Leu Gly Asp Leu Val Glu Ser Gln Phe Lys225 230 235 240Arg Asp Leu Gly Ile Lys Asp Met Ser Asn Leu Leu Pro Gly His Gly

245 250 255Gly Leu Met Asp Arg Leu Asp Gly Met Leu Pro Ala Ala Met Val Thr

260 265 270Trp Leu Ile Leu Ser Val Ile Ser Ser Ser Tyr Pro Ser

275280285<210>101<211>600<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (577)<223>RXA02599<400>101gatcaagcat catacgatgt cggagattgt ggcgggcgtt gttacaggag cagttgcaac 60cggcatttgt tatgcactcc tacttgcgta aaggagaatt atg gat cag cta atc 115

Met Asp Gln Leu Ile

1 5ctc gac gca ttt atc ggc ttg aga gtg act tgg ctg agt ccg gtg att 163Leu Asp Ala Phe Ile Gly Leu Arg Val Thr Trp Leu Ser Pro Val Ile

10 1520att ttg ttc acc cag ctc acc ggg cca aca ctg atg ttt gtg tat gcg 211Ile Leu Phe Thr Gln Leu Thr Gly Pro Thr Leu Met Phe Val Tyr Ala

25 30 35ctt gtg tgg ggc ttg ttg cgc aag agc gcc act gcc ccg atc gcg gtg 259Leu Val Trp Gly Leu Leu Arg Lys Ser Ala Thr Ala Pro Ile Ala Val

40 45 50ggg ctg gct aat ctg atc agt cat ttt ctc aag agg gcg ttt gaa cgg 307Gly Leu Ala Asn Leu Ile Ser His Phe Leu Lys Arg Ala Phe Glu Arg

55 60 65cct cga cca aat aca gca gag cac ttg gtt gta gaa act aac ttt tca 355Pro Arg Pro Asn Thr Ala Glu His Leu Val Val Glu Thr Asn Phe Ser 70 75 80 85ttc cct tct ggt cat gct gtg ggc gct gca gca tgt gcc gtg gca gtg 403Phe Pro Ser Gly His Ala Val Gly Ala Ala Ala Cys Ala Val Ala Val

90 95 100ggg tac tcc gtg aac cgg tgg tgg aaa ctc acg ctg tgg gta atc gcg 451Gly Tyr Ser Val Asn Arg Trp Trp Lys Leu Thr Leu Trp Val Ile Ala

105 110 115ctg ctt gtg ggg ctg tct cgg ttg tat gtc ggt gtg cat tgg ccc agc 499Leu Leu Val Gly Leu Ser Arg Leu Tyr Val Gly Val His Trp Pro Ser

120 125 130gat gtg ctt gcc ggc tgg gcc atc ggt gcg ttg act tca gtg gtg gtg 547Asp Val Leu Ala Gly Trp Ala Ile Gly Ala Leu Thr Ser Val Val Val

135140145 ttt acc agc tgg aac ctc ctc cag cgc cgc tgaaaccact gctgaaagtg 597Phe Thr Ser Trp Asn Leu Leu Gln Arg Arg 150155 gta 600<210>102<211>159<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>102Met Asp Gln Leu Ile Leu Asp Ala Phe Ile Gly Leu Arg Val Thr Trp 151015 Leu Ser Pro ValIle Ile Leu Phe Thr Gln Leu Thr Gly Pro Thr Leu

20 25 30Met Phe Val Tyr Ala Leu Val Trp Gly Leu Leu Arg Lys Ser Ala Thr

35 40 45Ala Pro Ile Ala Val Gly Leu Ala Asn Leu Ile Ser His Phe Leu Lys

50 55 60Arg Ala Phe Glu Arg Pro Arg Pro Asn Thr Ala Glu His Leu Val Val65 70 75 80Glu Thr Asn Phe Ser Phe Pro Ser Gly His Ala Val Gly Ala Ala Ala

85 90 95Cys Ala Val Ala Val Gly Tyr Ser Val Asn Arg Trp Trp Lys Leu Thr

100 105 110Leu Trp Val Ile Ala Leu Leu Val Gly Leu Ser Arg Leu Tyr Val Gly

115 120 125Val His Trp Pro Ser Asp Val Leu Ala Gly Trp Ala Ile Gly Ala Leu

130135140 Thr Ser Val Val Val Phe Thr Ser Trp Asn Leu Leu Gln Arg Arg 145150155<210>103<211>999<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101) } (976)<223>RXN02638<400>103ctctgttgtt gttcctgagg cgcttcgtcc attcgtgggc aaagacgtgc tcaagccagt 60gaaacaagcc ggttaattaa gcggaaagct cgtggtcgac atg gtc aaa agg ttt 115

Met Val Lys Arg Phe

1 5ggc ttt ttc gta gag gat tcc ctg cct aag gtt ccg ctg cat ccc gaa 163Gly Phe Phe Val Glu Asp Ser Leu Pro Lys Val Pro Leu His Pro Glu

10 15 20gag tca cgg gag acg ttt tat ggg cgc atc atc att agt gct gtg cgg 211Glu Ser Arg Glu Thr Phe Tyr Gly Arg IleIle Ile Ser Ala Val Arg

25 30 35acg gtg atg aaa gcc cag gat gtg cag att tcc atc ttc ggt gcg gag 259Thr Val Met Lys Ala Gln Asp Val Gln Ile Ser Ile Phe Gly Ala Glu

40 45 50aac att ccg acc acc ggc ggc gca ctt ttc gca tca acc aca ctg gtt 307Asn Ile Pro Thr Thr Gly Gly Ala Leu Phe Ala Ser Thr Thr Leu Val

55 60 65att atg act tca ttc tgg gtg gta tcc ccc gca ttc gtg cgg ggt aag 355Ile Met Thr Ser Phe Trp Val Val Ser Pro Ala Phe Val Arg Gly Lys 70 75 80 85cgc ctg gtt cga ttc atg gcg aag aag gaa att ttc gac acc cca gtt 403Arg Leu Val Arg Phe Met Ala Lys Lys Glu Ile Phe Asp Thr Pro Val

90 95 100gtc ggc acc ctc atg cgc tgg atg aag cac gtc tct gtg gac cgc tcc 451Val Gly Thr Leu Met Arg Trp Met Lys His Val Ser Val Asp Arg Ser

105 110 115gca ggt gcc ggt tcc atg gaa gat gcg cgg aag cgt ctc gac gcc ggc 499Ala Gly Ala Gly Ser Met Glu Asp Ala Arg Lys Arg Leu Asp Ala Gly

120 125 130agc ctc gtc ggt atc ttc cct gag gcg acg gtg tca cgg tcc ttt gaa 547Ser Leu Val Gly Ile Phe Pro Glu Ala Thr Val Ser Arg Ser Phe Glu

135 140 145atc aag gaa cta aaa act ggc gcc gtc cgc atc gcc gac agc gct aac 595Ile Lys Glu Leu Lys Thr Gly Ala Val Arg Ile Ala Asp Ser Ala Asn150 155 160 165gtt ccg ctg ctg cca ctt att att tgg ggc ggc cag cgc atc atc acc 643Val Pro Leu Leu Pro Leu Ile Ile Trp Gly Gly Gln Arg Ile Ile Thr

170 175 180aaa gac atc gag cgc gac ttc ggc cgc tcc cac atc ccc gta ttc atc 691Lys Asp Ile Glu Arg Asp Phe Gly Arg Ser His Ile Pro Val Phe Ile

185 190 195agc gtg ggt gaa ccc gtc gac gcc agc ggc gat ccc gac gaa gca acg 739Ser Val Gly Glu Pro Val Asp Ala Ser Gly Asp Pro Asp Glu Ala Thr

200 205 210gaa cgc ctc tac gag gct atg aaa aag ctt ctc gac gaa acc cgc acc 787Glu Arg Leu Tyr Glu Ala Met Lys Lys Leu Leu Asp Glu Thr Arg Thr

215 220 225gcc tac gaa caa aag tat ggc cca ttc gaa ggt gga gaa ttg tgg cgc 835Ala Tyr Glu Gln Lys Tyr Gly Pro Phe Glu Gly Gly Glu Leu Trp Arg230 235 240 245ccg aaa tcc ctc ggc ggc ggc gcc cca acg ttg gag cag gcg aaa atg 883Pro Lys Ser Leu Gly Gly Gly Ala Pro Thr Leu Glu Gln Ala Lys Met

250 255 260ttg gaa atc gcc gaa cgg gaa cgt cga caa gca aaa cgc gcg gca aag 931Leu Glu Ile Ala Glu Arg Glu Arg Arg Gln Ala Lys Arg Ala Ala Lys

265 270 275gtc gcc aag aaa cgc acc acc ttt ata agg aaa atc ttt aaa aaa 976Val Ala Lys Lys Arg Thr Thr Phe Ile Arg Lys Ile Phe Lys Lys

280285290 tgattgcact gggttcagcg ccc 999<210>104<211>292<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>104Met Val Lys Arg Phe Gly Phe Phe Val Glu Asp Ser Leu Pro Lys Val 151015 Pro Leu His Pro Glu Glu Ser Arg Glu Thr Phe Tyr Gly Arg Ile Ile

20 25 30Ile Ser Ala Val Arg Thr Val Met Lys Ala Gln Asp Val Gln Ile Ser

35 40 45Ile Phe Gly Ala Glu Asn Ile Pro Thr Thr Gly Gly AlaLeu Phe Ala

50 55 60Ser Thr Thr Leu Val Ile Met Thr Ser Phe Trp Val Val Ser Pro Ala 65 70 75 80Phe Val Arg Gly Lys Arg Leu Val Arg Phe Met Ala Lys Lys Glu Ile

85 90 95Phe Asp Thr Pro Val Val Gly Thr Leu Met Arg Trp Met Lys His Val

100 105 110Ser Val Asp Arg Ser Ala Gly Ala Gly Ser Met Glu Asp Ala Arg Lys

115 120 125Arg Leu Asp Ala Gly Ser Leu Val Gly Ile Phe Pro Glu Ala Thr Val

130 135 140Ser Arg Ser Phe Glu Ile Lys Glu Leu Lys Thr Gly Ala Val Arg Ile145 150 155 160Ala Asp Ser Ala Asn Val Pro Leu Leu Pro Leu Ile Ile Trp Gly Gly

165 170 175Gln Arg Ile Ile Thr Lys Asp Ile Glu Arg Asp Phe Gly Arg Ser His

180 185 190Ile Pro Val Phe Ile Ser Val Gly Glu Pro Val Asp Ala Ser Gly Asp

195 200 205Pro Asp Glu Ala Thr Glu Arg Leu Tyr Glu Ala Met Lys Lys Leu Leu

210 215 220Asp Glu Thr Arg Thr Ala Tyr Glu Gln Lys Tyr Gly Pro Phe Glu Gly225 230 235 240Gly Glu Leu Trp Arg Pro Lys Ser Leu Gly Gly Gly Ala Pro Thr Leu

245 250 255Glu Gln Ala Lys Met Leu Glu Ile Ala Glu Arg Glu Arg Arg Gln Ala

260 265 270Lys Arg Ala Ala Lys Val Ala Lys Lys Arg Thr Thr Phe Ile Arg Lys

275 280 285Ile Phe Lys Lys

290<210>105<211>534<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(8.) (511)<223>FRXA02638<400>105atgaaga atg gcg cgg aag cgt ctt aac gcc ggc agc ctc gtc ggt atc 49

Met Ala Arg Lys Arg Leu Asn Ala Gly Ser Leu Val Gly Ile

1 5 10ttc cct gag gcg acg gtg tca cgg tcc ttt gaa atc aag gaa cta aaa 97Phe Pro Glu Ala Thr Val Ser Arg Ser Phe Glu Ile Lys Glu Leu Lys 15 20 25 30act ggc gcc gtc cgc atc gcc gac agc gct aac gtt ccg ctg ctg cca 145Thr Gly Ala Val Arg Ile Ala Asp Ser Ala Asn Val Pro Leu Leu Pro

35 40 45ctt att att tgg ggc ggc cag cgc atc atc acc aaa gac atc gag cgc 193Leu Ile Ile Trp Gly Gly Gln Arg Ile Ile Thr Lys Asp Ile Glu Arg

50 55 60gac ttc ggc cgc tcc cac atc ccc gta ttc atc agc gtg ggt gaa ccc 241Asp Phe Gly Arg Ser His Ile Pro Val Phe Ile Ser Val Gly Glu Pro

65 70 75gtc gac gcc agc ggc gat ccc gac gaa gca acg gaa cgc ctc tac gag 289Val Asp Ala Ser Gly Asp Pro Asp Glu Ala Thr Glu Arg Leu Tyr Glu

80 85 90gct atg aaa aag ctt ctc gac gaa acc cgc acc gcc tac gaa caa aag 337Ala Met Lys Lys Leu Leu Asp Glu Thr Arg Thr Ala Tyr Glu Gln Lys 95 100 105 110tat ggc cca ttc gaa ggt gga gaa ttg tgg cgc ccg aaa tcc ctc ggc 385Tyr Gly Pro Phe Glu Gly Gly Glu Leu Trp Arg Pro Lys Ser Leu Gly

115 120125ggc ggc gcc cca acg ttg gag cag gcg aaa atg ttg gaa atc gcc gaa 433Gly Gly Ala Pro Thr Leu Glu Gln Ala Lys Met Leu Glu Ile Ala Glu

130 135 140cgg gaa cgt cga caa gca aaa cgc gcg gca aag gtc gcc aag aaa cgc 481Arg Glu Arg Arg Gln Ala Lys Arg Ala Ala Lys Val Ala Lys Lys Arg

145 150 155acc acc ttt ata agg aaa atc ttt aaa aaa tgattgcact gggttcagcg 531Thr Thr Phe Ile Arg Lys Ile Phe Lys Lys

160165 ccc 534<210>106<211>168<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>106Met Ala Arg Lys Arg Leu Asn Ala Gly Ser Leu Val Gly Ile Phe Pro 151015 Glu Ala Thr Val Ser Arg Ser Phe Glu Ile Lys Glu Leu Lys Thr Gly

20 25 30Ala Val Arg Ile Ala Asp Ser Ala Asn Val Pro Leu Leu Pro Leu Ile

35 40 45Ile Trp Gly Gly Gln Arg Ile Ile Thr Lys Asp Ile Glu Arg Asp Phe

50 55 60Gly Arg Ser His Ile Pro Val Phe Ile Ser Val Gly Glu Pro Val Asp 65 70 75 80Ala Ser Gly Asp Pro Asp Glu Ala Thr Glu Arg Leu Tyr Glu Ala Met

85 90 95Lys Lys Leu Leu Asp Glu Thr Arg Thr Ala Tyr Glu Gln Lys Tyr Gly

100 105 110Pro Phe Glu Gly Gly Glu Leu Trp Arg Pro Lys Ser Leu Gly Gly Gly

115 120 125Ala Pro Thr Leu Glu Gln Ala Lys Met Leu Glu Ile Ala Glu Arg Glu

130 135 140Arg Arg Gln Ala Lys Arg Ala Ala Lys Val Ala Lys Lys Arg Thr Thr145 150 155 160Phe Ile Arg Lys Ile Phe Lys Lys

165<210>107<211>637<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (637)<223>RXA00856<400>107gtttttagga atagagtggg ctcaagcttt gtgacaagtt ttttggagaa atcattacta 60gtcgtagtct tcaatttggg tgcaggtagg gtggaacacc gtg agt gat gta tca 115

Val Ser Asp Val Ser

1 5gca ggc gta aat ggc gca caa gat cca agc aat caa gcg gtc aag cct 163Ala Gly Val Asn Gly Ala Gln Asp Pro Ser Asn Gln Ala Val Lys Pro

10 15 20tcc aac tgg aac ctt ccg aac ttc ttg acc agc ttg cgt atc att gtc 211Ser Asn Trp Asn Leu Pro Asn Phe Leu Thr Ser Leu Arg Ile Ile Val

25 30 35atc cct ttg ttt gcg tgg ctt acg ctt aaa ggt gag acg gaa aac aat 259Ile Pro Leu Phe Ala Trp Leu Thr Leu Lys Gly Glu Thr Glu Asn Asn

40 45 50gct ttt gcc tgg tgg gcg ttg gtt gtt ttc att ttg ctc atg atc acc 307Ala Phe Ala Trp Trp Ala Leu Val Val Phe Ile Leu Leu Met Ile Thr

55 60 65gac aag ctt gac ggc gat att gcg cga gca cgt ggc ctg gtc act gac 355Asp Lys Leu Asp Gly Asp Ile Ala Arg Ala Arg Gly Leu Val Thr Asp 70 75 80 85ttt ggc aag atc gcg gat ccg att gcc gat aag gcg ttg atg acc aca 403Phe Gly Lys Ile Ala Asp Pro Ile Ala Asp Lys Ala Leu Met Thr Thr

90 95 100gca ttt gtc tgt ttc aac atc atc ggc att ttg ccc tgg tgg gtc act 451AlaPhe Val Cys Phe Asn Ile Ile Gly Ile Leu Pro Trp Trp Val Thr

105 110 115gcg ttg att gtg ctt cga gag ttc ggc att acc atc tgg cgt ttc ttc 499Ala Leu Ile Val Leu Arg Glu Phe Gly Ile Thr Ile Trp Arg Phe Phe

120 125 130caa ctg cgc gct gga aat gtt gtg cct gca tca aag ggg ggc aag ctt 547Gln Leu Arg Ala Gly Asn Val Val Pro Ala Ser Lys Gly Gly Lys Leu

135 140 145aag act gct ctg cag act gtt gcc gtt gct ctg tat ctg tgc cct ttc 595Lys Thr Ala Leu Gln Thr Val Ala Val Ala Leu Tyr Leu Cys Pro Phe150 155 160 165cca agt tgg atg gat att cca agc cag atc gtc atg tat gca 637Pro Ser Trp Met Asp Ile Pro Ser Gln Ile Val Met Tyr Ala

170175<210>108<211>179<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>108Val Ser Asp Val Ser Ala Gly Val Asn Gly Ala Gln Asp Pro Ser Asn 151015 Gln Ala Val Lys Pro Ser Asn Trp Asn Leu Pro Asn Phe Leu Thr Ser

20 25 30Leu Arg Ile Ile Val Ile Pro Leu Phe Ala Trp Leu Thr Leu Lys Gly

35 40 45Glu Thr Glu Asn Asn Ala Phe Ala Trp Trp Ala Leu Val Val Phe Ile

50 55 60Leu Leu Met Ile Thr Asp Lys Leu Asp Gly Asp Ile Ala Arg Ala Arg 65 70 75 80Gly Leu Val Thr Asp Phe Gly Lys Ile Ala Asp Pro Ile Ala Asp Lys

85 90 95Ala Leu Met Thr Thr Ala Phe Val Cys Phe Asn Ile Ile Gly Ile Leu

100 105 110Pro Trp Trp Val Thr AlaLeu Ile Val Leu Arg Glu Phe Gly Ile Thr

115 120 125Ile Trp Arg Phe Phe Gln Leu arg Ala Gly Asn Val Val Pro Ala Ser

130 135 140Lys Gly Gly Lys Leu Lys Thr Ala Leu Gln Thr Val Ala Val Ala Leu145 150 155 160Tyr Leu Cys Pro Phe Pro Ser Trp Met Asp Ile Pro Ser Gln Ile Val

165170175 Met Tyr Ala<210>109<211>780<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (757)<223>RXA02511<400>109ccatgcttgc gcaagcatgg ggcaccattg atggggcacc aggcactgtc gacccaacgc 60tgacttcagc gatccgtacc gcagcaccga aggagcactg atg ctg gga ctt cat 115

Met Leu Gly Leu His

1 5gga cgt aag cct gcg cag gtt att gtt gag cct gtt gcc aaa ttg atg 163Gly Arg Lys Pro Ala Gln Val Ile Val Glu Pro Val Ala Lys Leu Met

10 15 20atc aag ttg aag gtg acg cct aat cag ctc acc tta gtc agc gct ggc 211Ile Lys Leu Lys Val Thr Pro Asn Gln Leu Thr Leu Val Ser Ala Gly

25 30 35ctc acc gtt ggg gtg gct ttg ctg ctg att cct acg ggg cat ttg att 259Leu Thr Val Gly Val Ala Leu Leu Leu Ile Pro Thr Gly His Leu Ile

40 45 50tgg gcg gca gtt ttg acg ggc ctg ttt gcg gct ttc gac atg att gat 307Trp Ala Ala Val Leu Thr Gly Leu Phe Ala Ala Phe Asp Met Ile Asp

55 60 65ggc acg gtt gct cgc atg caa ggt ggt ggc acc aaa ttt ggt gcc acc 355Gly Thr Val Ala Arg Met Gln Gly Gly Gly Thr Lys Phe Gly Ala Thr 70 75 80 85ttg gat gcc acg tgt gac cgc atc act gat ggt gca cta ttt ggt gcg 403Leu Asp Ala Thr Cys Asp Arg Ile Thr Asp Gly Ala Leu Phe Gly Ala

90 95 100att acc tgg tgg ctg gtg tat tcc tac gat gca cca cag gca ttg gtc 451Ile Thr Trp Trp Leu Val Tyr Ser Tyr Asp Ala Pro Gln Ala Leu Val

105 110 115gct gcc tcc ttg gtt tgt ttg gtt gcc tcc cag gtg atc tct tac gtg 499Ala Ala Ser Leu Val Cys Leu Val Ala Ser Gln Val Ile Ser Tyr Val

120 125 130aaa gcc agg gga gag gcc tcc gga ttc acc atg gac ggc ggt ctc gtg 547Lys Ala Arg Gly Glu Ala Ser Gly Phe Thr Met Asp Gly Gly Leu Val

135 140 145gaa cgc cct gag cgt ctg att gtc agc ctt gtt ggt ttg ggg ctg acc 595Glu Arg Pro Glu Arg Leu Ile Val Ser Leu Val Gly Leu Gly Leu Thr150 155 160 165gga atg ggc gtt cca tat gcc atc gat gtg gca ctg tgg gcc ctt gca 643Gly Met Gly Val Pro Tyr Ala Ile Asp Val Ala Leu Trp Ala Leu Ala

170 175 180gct ggc agt att tac act gtt gtg cag cgc ttg gtc atg gct gga aag 691Ala Gly Ser Ile Tyr Thr Val Val Gln Arg Leu Val Met Ala Gly Lys

185 190 195tcc cca ttg gct aag gaa ttt acc aag gca cca gca ggt gcg aag gca 739Ser Pro Leu Ala Lys Glu Phe Thr Lys Ala Pro Ala Gly Ala Lys Ala

200 205 210gat tac agc aac acc aaa taaaaattag ccgagggagc atc 780Asp Tyr Ser Asn Thr Lys

215<210>110<211>219<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>110Met Leu Gly Leu His Gly Arg Lys Pro Ala Gln Val Ile Val Glu Pro 151015 Val Ala Lys Leu Met Ile Lys Leu Lys Val Thr Pro Asn Gln Leu Thr

20 25 30Leu Val Ser Ala Gly Leu Thr Val Gly Val Ala Leu Leu Leu Ile Pro

35 40 45Thr Gly His Leu Ile Trp Ala Ala Val Leu Thr Gly Leu Phe Ala Ala

50 55 60Phe Asp Met Ile Asp Gly Thr Val Ala Arg Met Gln Gly Gly Gly Thr 65 70 75 80Lys Phe Gly Ala Thr Leu Asp Ala Thr Cys Asp Arg Ile Thr Asp Gly

85 90 95Ala Leu Phe Gly Ala Ile Thr Trp Trp Leu Val Tyr Ser Tyr Asp Ala

100 105 110Pro Gln Ala Leu Val Ala Ala Ser Leu Val Cys Leu Val Ala Ser Gln

115 120 125Val Ile Ser Tyr Val Lys Ala Arg Gly Glu Ala Ser Gly Phe Thr Met

130 135 140Asp Gly Gly Leu Val Glu Arg Pro Glu Arg Leu Ile Val Ser Leu Val145 150 155 160Gly Leu Gly Leu Thr Gly Met Gly Val Pro Tyr Ala Ile Asp Val Ala

165 170 175Leu Trp Ala Leu Ala Ala Gly Ser Ile Tyr Thr Val Val Gln Arg Leu

180 185 190Val Met Ala Gly Lys Ser Pro Leu Ala Lys Glu Phe Thr Lys Ala Pro

195 200 205Ala Gly Ala Lys Ala Asp Tyr Ser Asn Thr Lys

210215<210>111<211>678<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (655)<223>RXN02836<400>111ccatcactcg gcttcaccgt ctacggtgct gcccgcagga cagagcgccc ccaaaagctc 60gcttcagacg ggatccaccc cctcgagatg gacgtcaccg atg aca atc gat gaa 115

Met Thr Ile Asp Glu

1 5ggc cgt cgc cag ttc gag gtc aat gta ttc ggc gcg atg gcc ctc acc 163Gly Arg Arg Gln Phe Glu Val Asn Val Phe Gly Ala Met Ala Leu Thr

10 15 20cga ctc gtc ctg ccc cac atg cag aaa caa aag tgg ggg acg atc gtg 211Arg Leu Val Leu Pro His Met Gln Lys Gln Lys Trp Gly Thr Ile Val

25 30 35aac atc aca tcg atg ggc ggg aag atc tac acg cct ctc ggc ggc tgg 259Asn Ile Thr Ser Met Gly Gly Lys Ile Tyr Thr Pro Leu Gly Gly Trp

40 45 50tat cac ggc acc aag ttc gcc ctc gag gcc ctc tcg gac gcc ctc cgc 307Tyr His Gly Thr Lys Phe Ala Leu Glu Ala Leu Ser Asp Ala Leu Arg

55 60 65ctg gag gtc gcc cca ttc ggc atc gac gtt gtt gtc atc gaa ccg ggc 355Leu Glu Val Ala Pro Phe Gly Ile Asp Val Val Val Ile Glu Pro Gly 70 75 80 85ggc atc gcc acc gag tgg gga gga atc gct gcc gac aat ctc gac gca 403Gly Ile Ala Thr Glu Trp Gly Gly Ile Ala Ala Asp Asn Leu Asp Ala

90 95 100gtg tcg aaa gac agc gca tac aag cgc cag gct gac gca gta tcg aag 451Val Ser Lys Asp Ser Ala Tyr Lys Arg Gln Ala Asp Ala Val Ser Lys

105 110 115tcg ttg cga tct gag gcg aac agc aac cgc aac tca cca ccg tcg gtt 499Ser Leu Arg Ser Glu Ala Asn Ser Asn Arg Asn Ser Pro ProSer Val

120 125 130gtc gcc gat gcg att gga aag gcc gtg acg gca cgt cac ccc aag acc 547Val Ala Asp Ala Ile Gly Lys Ala Val Thr Ala Arg His Pro Lys Thr

135 140 145cgc tat gcc atc ggc ttc ggt gcc aaa ccg ctg att gcc tcg cgc aac 595Arg Tyr Ala Ile Gly Phe Gly Ala Lys Pro Leu Ile Ala Ser Arg Asn150 155 160 165atc ctc acc gat cgc cag ttc gac cca gtg atc act cga gcg act ggc 643Ile Leu Thr Asp Arg Gln Phe Asp Pro Val Ile Thr Arg Ala Thr Gly

170 175 180gtc ccc cgc gac tgaccactct tctgcgcccg tca 678Val Pro Arg Asp

185<210>112<211>185<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>112Met Thr Ile Asp Glu Gly Arg Arg Gln Phe Glu Val Asn Val Phe Gly 151015 Ala Met Ala Leu Thr Arg Leu Val Leu Pro His Met Gln Lys Gln Lys

20 25 30Trp Gly Thr Ile Val Asn Ile Thr Ser Met Gly Gly Lys Ile Tyr Thr

35 40 45Pro Leu Gly Gly Trp Tyr His Gly Thr Lys Phe Ala Leu Glu Ala Leu

50 55 60Ser Asp Ala Leu Arg Leu Glu Val Ala Pro Phe Gly Ile Asp Val Val 65 70 75 80Val Ile Glu Pro Gly Gly Ile Ala Thr Glu Trp Gly Gly Ile Ala Ala

85 90 95Asp Asn Leu Asp Ala Val Ser Lys Asp Ser Ala Tyr Lys Arg Gln Ala

100 105 110Asp Ala Val Ser Lys Ser Leu Arg Ser Glu Ala Asn Ser Asn Arg Asn

115120 125Ser Pro Pro Ser Val Val Ala Asp Ala Ile Gly Lys Ala Val Thr Ala

130 135 140Arg His Pro Lys Thr Arg Tyr Ala Ile Gly Phe Gly Ala Lys Pro Leu145 150 155 160Ile Ala Ser Arg Asn Ile Leu Thr Asp Arg Gln Phe Asp Pro Val Ile

165 170 175Thr Arg Ala Thr Gly Val Pro Arg Asp

180185<210>113<211>406<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (406)<223>FRXA02836<400>113ccatcactcg gcttcaccgt ctacggtgct gcccgcagga cagagcgccc ccaaaagctc 60gcttcagacg ggatccaccc cctcgagatg gacgtcaccg atg aca atc gat gaa 115

Met Thr Ile Asp Glu

1 5ggc cgt cgc cag ttc gag gtc aat gta ttc ggc gcg atg gcc ctc acc 163Gly Arg Arg Gln Phe Glu Val Asn Val Phe Gly Ala Met Ala Leu Thr

10 15 20cga ctc gtc ctg ccc cac atg cag aaa caa aag tgg ggg acg atc gtg 211Arg Leu Val Leu Pro His Met Gln Lys Gln Lys Trp Gly Thr Ile Val

25 30 35aac atc aca tcg atg ggc ggg aag atc tac acg cct ctc ggc ggc tgg 259Asn Ile Thr Ser Met Gly Gly Lys Ile Tyr Thr Pro Leu Gly Gly Trp

40 45 50tat cac ggc acc aag ttc gcc ctc gag gcc ctc tcg gac gcc ctc cgc 307Tyr His Gly Thr Lys Phe Ala Leu Glu Ala Leu Ser Asp Ala Leu Arg

55 60 65ctg gag gtc gcc cca ttc ggc atc gac gtt gtt gtc atc gaa ccg ggc 355Leu Glu Val Ala Pro Phe Gly Ile Asp Val Val Val Ile Glu Pro Gly 70 75 80 85ggc atc gcc acc gag tgg gga gga atc gct gcc gac aat ctc gac gca 403Gly Ile Ala Thr Glu Trp Gly Gly Ile Ala Ala Asp Asn Leu Asp Ala

9095100 gtg 406Val<210>114<211>102<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>114Met Thr Ile Asp Glu Gly Arg Arg Gln Phe Glu Val Asn Val Phe Gly 151015 Ala Met Ala Leu Thr Arg Leu Val Leu Pro His Met Gln Lys Gln Lys

20 25 30Trp Gly Thr Ile Val Asn Ile Thr Ser Met Gly Gly Lys Ile Tyr Thr

35 40 45Pro Leu Gly Gly Trp Tyr His Gly Thr Lys Phe Ala Leu Glu Ala Leu

50 55 60Ser Asp Ala Leu Arg Leu Glu Val Ala Pro Phe Gly Ile Asp Val Val 65 70 75 80Val Ile Glu Pro Gly Gly Ile Ala Thr Glu Trp Gly Gly Ile Ala Ala

85 90 95Asp Asn Leu Asp Ala Val

100<210>115<211>1227<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1204)<223>RXA02578<400>115ggcaaaaatg aggaacagca cgcccgcaat aatgaggacc gttgcagatc gcttcataaa 60aacagcccac acctttccgc taaactcgca tgttgaaata atg tct acc caa tca 115

Met Ser Thr Gln Ser

1 5tat gca ccc atc cgc cat cgc gga ttc atc agc tca ctc gag gga cta 163Tyr Ala Pro Ile Arg His Arg Gly Phe Ile Ser Ser Leu Glu Gly Leu

10 15 20cgc gcaatc gcc tcc ctg gga gtc ttg gcg acc cac gtt gca ttc caa 211Arg Ala Ile Ala Ser Leu Gly Val Leu Ala Thr His Val Ala Phe Gln

25 30 35acc tcc gtc gac ccc gcc agc aac atc ggt gca gta ctc gcg cgt ttc 259Thr Ser Val Asp Pro Ala Ser Asn Ile Gly Ala Val Leu Ala Arg Phe

40 45 50gac ttt ttc gtc gcc gtc ttc ttc gcc ctc tcc gcc ttc gtt ctt tgg 307Asp Phe Phe Val Ala Val Phe Phe Ala Leu Ser Ala Phe Val Leu Trp

55 60 65cga cgc cgc gcc ggg caa cca gtg gga ctg tac tac ctc aaa cgc cta 355Arg Arg Arg Ala Gly Gln Pro Val Gly Leu Tyr Tyr Leu Lys Arg Leu 70 75 80 85gcc cgc atc atg ccc gca tac tgg gca acg gtc att gca gtc ctg ctg 403Ala Arg Ile Met Pro Ala Tyr Trp Ala Thr Val Ile Ala Val Leu Leu

90 95 100ttt att ccc acc ggc ccc tgg tta gcc aac ctg acg atg acc caa atc 451Phe Ile Pro Thr Gly Pro Trp Leu Ala Asn Leu Thr Met Thr Gln Ile

105 110 115tac tgg cca gac ggg ctc atg aca ggc ctc acc cac ctt tgg tcc ctg 499Tyr Trp Pro Asp Gly Leu Met Thr Gly Leu Thr His Leu Trp Ser Leu

120 125 130tgc gtg gaa gtg gcg ttt tac ctg gtg atg ccg ctt ctc gcg tgg gtg 547Cys Val Glu Val Ala Phe Tyr Leu Val Met Pro Leu Leu Ala Trp Val

135 140 145ttg gat agg ttt ggt cgg ccg gtg cgc atc ctg ttg att gtt ggt ggg 595Leu Asp Arg Phe Gly Arg Pro Val Arg Ile Leu Leu Ile Val Gly Gly150 155 160 165gca gtg ttg agt ctg gcg tgg ccg tgg att ccc ctt gtg gag cat gcg 643Ala Val Leu Ser Leu Ala Trp Pro Trp Ile Pro Leu Val Glu His Ala

170 175 180ttg gac gag ggg tgg gcg aac atg cag atc tgg cca ccc gct tac gct 691Leu Asp Glu Gly Trp Ala Asn Met Gln Ile Trp Pro Pro Ala Tyr Ala

185 190 195tgc tgg ttt gca gtc ggc atg atc gcc gca gaa att gaa gga gtt cga 739Cys Trp Phe Ala Val Gly Met Ile Ala Ala Glu Ile Glu Gly Val Arg

200 205 210ttc cca cgg gtt ccg agc ttt gtg tgg gtg ggt tta gct tta gtg gtc 787Phe Pro Arg Val Pro Ser Phe Val Trp Val Gly Leu Ala Leu Val Val

215 220 225gct tgg atc gcg ggc caa gaa tgg ttc gga cca cta ggt tta gtg cac 835Ala Trp Ile Ala Gly Gln Glu Trp Phe Gly Pro Leu Gly Leu Val His230 235 240 245ccc agc ccc tgg gaa ttc aac tta aga gtc ctc gcg ggc aca ctt ttc 883Pro Ser Pro Trp Glu Phe Asn Leu Arg Val Leu Ala Gly Thr Leu Phe

250 255 260gct gta ttt ctg gtg gtt ccc tac gcg ctg ggt acg ccc tct cgg ctt 931Ala Val Phe Leu Val Val Pro Tyr Ala Leu Gly Thr Pro Ser Arg Leu

265 270 275ctt gat tcc agt tgg atg aaa acg ctc ggc acc tgg tcg tat tcc atc 979Leu Asp Ser Ser Trp Met Lys Thr Leu Gly Thr Trp Ser Tyr Ser Ile

280 285 290ttc ctc tgg cac ctt ccc gtg ctg acg att gtg ttc cca ctg ctc ggg 1027Phe Leu Trp His Leu Pro Val Leu Thr Ile Val Phe Pro Leu Leu Gly

295 300 305ttg cct tta ttt agt gga aat ttc ctg ttg gtg ttc atc gtg acg gtc 1075Leu Pro Leu Phe Ser Gly Asn Phe Leu Leu Val Phe Ile Val Thr Val310 315 320 325ttg ttg acg atc cca gtt gcc gcc atc agc tac acc ttc atc gaa gag 1123Leu Leu Thr Ile Pro Val Ala Ala Ile Ser Tyr Thr Phe Ile Glu Glu

330 335 340ccc atc agc ggt gga ccc ggc gcg cca ttc agg ctg ggg gtc gtt agg 1171Pro Ile Ser Gly Gly Pro Gly Ala Pro Phe Arg Leu Gly Val Val Arg

345 350 355att cac cat ttt tct ggg ggt agg tct gga aaa tgatgaattg gcaccacgtc 1224Ile His His Phe Ser Gly Gly Arg Ser Gly Lys

360365 aag1227<210>116<211>368<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>116Met Ser Thr Gln Ser Tyr Ala Pro Ile Arg His Arg Gly Phe Ile Ser 151015 Ser Leu Glu Gly Leu Arg Ala Ile Ala Ser Leu Gly Val Leu Ala Thr

20 25 30His Val Ala Phe Gln Thr Ser Val Asp Pro Ala Ser Asn Ile Gly Ala

35 40 45Val Leu Ala Arg Phe Asp Phe Phe Val Ala Val Phe Phe Ala Leu Ser

50 55 60Ala Phe Val Leu Trp Arg Arg Arg Ala Gly Gln Pro Val Gly Leu Tyr 65 70 75 80Tyr Leu Lys Arg Leu Ala Arg Ile Met Pro Ala Tyr Trp Ala Thr Val

85 90 95Ile Ala Val Leu Leu Phe Ile Pro Thr Gly Pro Trp Leu Ala Asn Leu

100 105 110Thr Met Thr Gln Ile Tyr Trp Pro Asp Gly Leu Met Thr Gly Leu Thr

115 120 125His Leu Trp Ser Leu Cys Val Glu Val Ala Phe Tyr Leu Val Met Pro

130 135 140Leu Leu Ala Trp Val Leu Asp Arg Phe Gly Arg Pro Val Arg Ile Leu145 150 155160Leu Ile Val Gly Gly Ala Val Leu Ser Leu Ala Trp Pro Trp Ile Pro

165 170 175Leu Val Glu His Ala Leu Asp Glu Gly Trp Ala Asn Met Gln Ile Trp

180 185 190Pro Pro Ala Tyr Ala Cys Trp Phe Ala Val Gly Met Ile Ala Ala Glu

195 200 205Ile Glu Gly Val Arg Phe Pro Arg Val Pro Ser Phe Val Trp Val Gly

210 215 220Leu Ala Leu Val Val Ala Trp Ile Ala Gly Gln Glu Trp Phe Gly Pro225 230 235 240Leu Gly Leu Val His Pro Ser Pro Trp Glu Phe Asn Leu Arg Val Leu

245 250 255Ala Gly Thr Leu Phe Ala Val Phe Leu Val Val Pro Tyr Ala Leu Gly

260 265 270Thr Pro Ser Arg Leu Leu Asp Ser Ser Trp Met Lys Thr Leu Gly Thr

275 280 285Trp Ser Tyr Ser Ile Phe Leu Trp His Leu Pro Val Leu Thr Ile Val

290 295 300Phe Pro Leu Leu Gly Leu Pro Leu Phe Ser Gly Asn Phe Leu Leu Val305 310 315 320Phe Ile Val Thr Val Leu Leu Thr Ile Pro Val Ala Ala Ile Ser Tyr

325 330 335Thr Phe Ile Glu Glu Pro Ile Ser Gly Gly Pro Gly Ala Pro Phe Arg

340 345 350Leu Gly Val Val Arg Ile His His Phe Ser Gly Gly Arg Ser Gly Lys

355360365<210>117<211>924<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (901)<223>RXA02150<400>117gtgtttttcg gtgggctgcg atgacgcatg tccaccaaaa gagccacccc ttaaagaaat 60taaaaagtgg ttttggtagc ttcgcagcaa aatacacatc gtg ggt aac gta ttc 115

Val Gly Asn Val Phe

1 5tta gaa gtt cct aca gca gta aag cgc gaa gaa ggg gta aac cca aac 163Leu Glu Val Pro Thr Ala Val Lys Arg Glu Glu Gly Val Asn Pro Asn

10 15 20atc atg aaa aac aac tgg tat cgg ctt ttc aag tat gtg cta att ggc 211Ile Met Lys Asn Asn Trp Tyr Arg Leu Phe Lys Tyr Val Leu Ile Gly

25 30 35ccg ttt ttg cgt gtg tac aac cgc ccg gag atc gaa ggc aaa gaa aac 259Pro Phe Leu Arg Val Tyr Asn Arg Pro Glu Ile Glu Gly Lys Glu Asn

40 45 50atc cct gca gaa ggt gcc gcg atc atg gcg tcc aac cac gaa gca gtg 307Ile Pro Ala Glu Gly Ala Ala Ile Met Ala Ser Asn His Glu Ala Val

55 60 65atg gat tcc ttt tat ttt ccc ctg ctg tgc cca cgg cag ctg acc ttc 355Met Asp Ser Phe Tyr Phe Pro Leu Leu Cys Pro Arg Gln Leu Thr Phe 70 75 80 85cca gcg aag gcc gaa tac ttc aca tca cca ggt att aaa ggc aag atg 403Pro Ala Lys Ala Glu Tyr Phe Thr Ser Pro Gly Ile Lys Gly Lys Met

90 95 100cag aag tgg ttt ttt act tct gtg ggg caa gta ccc ctg gac cgc acc 451Gln Lys Trp Phe Phe Thr Ser Val Gly Gln Val Pro Leu Asp Arg Thr

105 110 115gca gat aat gcc atg gat tct ttg atg aat acc gcc aaa atg gtg ctg 499Ala Asp Asn Ala Met Asp Ser Leu Met Asn Thr Ala Lys Met Val Leu

120 125 130gat cgg gga gac ctc ttc ggt att tac cct gaa gga tct cgt tcg ccc 547Asp Arg Gly Asp Leu Phe Gly Ile Tyr Pro Glu Gly Ser Arg Ser Pro

135 140 145gat ggt cgc atc tac aag ggc aaa acc gga atg gcc tat gtt gcg atg 595Asp Gly Arg Ile Tyr Lys Gly Lys Thr Gly Met Ala Tyr Val Ala Met150 155 160 165gaa act ggt acg aca gtt atc ccc gtt gcc atg att ggc agc cgg gac 643Glu Thr Gly Thr Thr Val Ile Pro Val Ala Met Ile Gly Ser Arg Asp

170 175 180gcg aac cct atc gga agt tgg ttt ccg aaa ccc gca aaa gtc agg atc 691Ala Asn Pro Ile Gly Ser Trp Phe Pro Lys Pro Ala Lys Val Arg Ile

185 190 195aag gta gga agc cca att gat ccc ctc gca ttc gtc aaa gaa car ggg 739Lys Val Gly Ser Pro Ile Asp Pro Leu Ala Phe Val Lys Glu His Gly

200 205 210ttg aag cct gga acc tac gaa gca gcg cgc aag ctg aca gat cac gtt 787Leu Lys Pro Gly Thr Tyr Glu Ala Ala Arg Lys Leu Thr Asp His Val

215 220 225atg ttc att ctt gct gat ctc act ggt cag ccg tat gtt gat gcg tac 835Met Phe Ile Leu Ala Asp Leu Thr Gly Gln Pro Tyr Val Asp Ala Tyr230 235 240 245tct aaa gat gtg aaa aac gct ctg gag gaa gga aaa gga tac ccg gag 883Ser Lys Asp Val Lys Asn Ala Leu Glu Glu Gly Lys Gly Tyr Pro Glu

250 255 260ggc aca gct cct tca cag taatcgggtc ttttctgtta aaa 924Gly Thr Ala Pro Ser Gln

265<210>118<211>267<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>118Val Gly Asn Val Phe Leu Glu Val Pro Thr Ala Val Lys Arg Glu Glu 151015 Gly Val Asn Pro Asn Ile Met Lys Asn Asn Trp Tyr Arg Leu Phe Lys

20 25 30Tyr Val Leu Ile Gly Pro Phe Leu Arg Val Tyr Asn Arg Pro Glu Ile

35 40 45Glu Gly Lys Glu Asn Ile Pro Ala Glu Gly Ala Ala Ile Met Ala Ser

50 55 60Asn His Glu Ala Val Met Asp Ser Phe Tyr Phe Pro Leu Leu Cys Pro 65 70 75 80Arg Gln Leu Thr Phe Pro Ala Lys Ala Glu Tyr Phe Thr Ser Pro Gly

85 90 95Ile Lys Gly Lys Met Gln Lys Trp Phe Phe Thr Ser Val Gly Gln Val

100 105 110Pro Leu Asp Arg Thr Ala Asp Asn Ala Met Asp Ser Leu Met Asn Thr

115 120 125Ala Lys Met Val Leu Asp Arg Gly Asp Leu Phe Gly Ile Tyr Pro Glu

130 135 140Gly Ser Arg Ser Pro Asp Gly Arg Ile Tyr Lys Gly Lys Thr Gly Met145 150 155 160Ala Tyr Val Ala Met Glu Thr Gly Thr Thr Val Ile Pro Val Ala Met

165 170 175Ile Gly Ser Arg Asp Ala Asn Pro Ile Gly Ser Trp Phe Pro Lys Pro

180 185 190Ala Lys Val Arg Ile Lys Val Gly Ser Pro Ile Asp Pro Leu Ala Phe

195 200 205Val Lys Glu His Gly Leu Lys Pro Gly Thr Tyr Glu Ala Ala Arg Lys

210 215 220Leu Thr Asp His Val Met Phe Ile Leu Ala Asp Leu Thr Gly Gln Pro225 230 235 240Tyr Val Asp Ala Tyr Ser Lys Asp Val Lys Asn Ala Leu Glu Glu Gly

245 250 255Lys Gly Tyr Pro Glu Gly Thr Ala Pro Ser Gln

260265<210>119<211>504<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (481)<223>RXA00607<400>119cactgccagc aacgccaacg gttgaacccg aaccagaagg cgatgaagac tggcccgaac 60ccatcaaccc cgcaggcgat aacaaagagg aggcaaaccg atg att ctc gca ctg 115

Met Ile Leu Ala Leu

1 5aca gtc gcg ata ctt ttc ggt gga ggt gtc tac ctc att cag caa cgc 163Thr Val Ala Ile Leu Phe Gly Gly Gly Val Tyr Leu Ile Gln Gln Arg

10 15 20gga atg gtg cgc atc gtc ttc ggc atg tca ctg atc ggc cac gca gcg 211Gly Met Val Arg Ile Val Phe Gly Met Ser Leu Ile Gly His Ala Ala

25 30 35aac ctg acc atc ctg tac gcc ggt gtg ccc acg tgg cgc ggc gaa gcc 259Asn Leu Thr Ile Leu Tyr Ala Gly Val Pro Thr Trp Arg Gly Glu Ala

40 45 50ttc ccc gac agg acc ccg ctt acc gac gcc gcc gat cca ctc ccc cag 307Phe Pro Asp Arg Thr Pro Leu Thr Asp Ala Ala Asp Pro Leu Pro Gln

55 60 65gcc ttc gtc ctc acc gcc atc gtc atc gcg atg gcc acc aca acc atc 355Ala Phe Val Leu Thr Ala Ile Val Ile Ala Met Ala Thr Thr Thr Ile 70 75 80 85atg ttg gcc ttg gca gca ctg gga cgc agc gac gac acc cgg tcc atc 403Met Leu Ala Leu Ala Ala Leu Gly Arg Ser Asp Asp Thr Arg Ser Ile

90 95 100gaa cca gat gac gat caa tcg cct ttg act act agc gct cgt tca gtc 451Glu Pro Asp Asp Asp Gln Ser Pro Leu Thr Thr Ser Ala Arg Ser Val

105 110 115acc aac cca aca gat cag gag gat aaa gct taaatggcca tggatgttct 501Thr Asn Pro Thr Asp Gln Glu Asp Lys Ala

120125 cct 504<210>120<211>127<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>120Met Ile Leu Ala Leu Thr Val Ala Ile Leu Phe Gly Gly Gly Val Tyr 151015 Leu Ile Gln Gln Arg Gly Met Val Arg Ile Val Phe Gly Met Ser Leu

20 25 30Ile Gly His Ala Ala Asn Leu Thr Ile Leu Tyr Ala Gly Val Pro Thr

35 40 45Trp Arg Gly Glu Ala Phe Pro Asp Arg Thr Pro Leu Thr Asp Ala Ala

50 55 60Asp Pro Leu Pro Gln Ala Phe Val Leu Thr Ala Ile Val Ile Ala Met 65 70 75 80Ala Thr Thr Thr Ile Met Leu Ala Leu Ala Ala Leu Gly Arg Ser Asp

85 90 95Asp Thr Arg Ser Ile Glu Pro Asp Asp Asp Gln Ser Pro Leu Thr Thr

100 105 110Ser Ala Arg Ser Val Thr Asn Pro Thr Asp Gln Glu Asp Lys Ala

115120125<210>121<211>1119<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1096)<223>RXA02397<400>121gtgtgaataa aacttgtttc ctggtcattt cccctactga actgcgctta tgcctatgct 60tagaaaccag agacaagctt aagaaggaca ggggccggcc atg aat gat ttc gaa 115

Met Asn Asp Phe Glu

1 5aca acc atc gat cgg atc tct aaa gaa caa gat ccc gca gcc cga agc 163Thr Thr Ile Asp Arg Ile Ser Lys Glu Gln Asp Pro Ala Ala Arg Ser

10 15 20cgc gtg gaa cag ttc att gtg gaa aca gta cgt gca cta ccc aac ttg 211Arg Val Glu Gln Phe Ile Val Glu Thr Val Arg Ala Leu Pro Asn Leu

25 30 35acc acc aaa caa ggt gca tcg ttg gct atc caa ctt ctt gat gcg gta 259Thr Thr Lys Gln Gly Ala Ser Leu Ala Ile Gln Leu Leu Asp Ala Val

40 45 50cag ctc gcg gat gcg gcg gga acc aag ggg ggt gcg tcg aca agc aat 307Gln Leu Ala Asp Ala Ala Gly Thr Lys Gly Gly Ala Ser Thr Ser Asn

55 60 65gct tca tcg ctg cct gac acc ttt gac gcg ctg acc agc ctg att ggc 355Ala Ser Ser Leu Pro Asp Thr Phe Asp Ala Leu Thr Ser Leu Ile Gly 70 75 80 85aag ctc gat gtg cgc agc gat tct gaa tgg cgc tcg ttt ggg ttc cag 403Lys Leu Asp Val Arg Ser Asp Ser Glu Trp Arg Ser Phe Gly Phe Gln

90 95 100cct tct gaa act gcg cac ccg cta atg atc gct atc cct gag att gag 451Pro Ser Glu Thr Ala His Pro Leu Met Ile Ala Ile Pro Glu Ile Glu

105 110 115att ttt tat cag cac acc gat gtg gag ccg gga agc gat gac gcc gtg 499Ile Phe Tyr Gln His Thr Asp Val Glu Pro Gly Set Asp Asp Ala Val

120 125 130gcg ccg gac ttt cag gaa aat cag gat atg tgg cgc agg cgt ctc gga 547Ala Pro Asp Phe Gln Glu Asn Gln Asp Met Trp Arg Arg Arg Leu Gly

135 140 145tct gtc acc gaa cca aac ctt ata tat aaa gag ttt tcc gga ccc ggc 595Ser Val Thr Glu Pro Asn Leu Ile Tyr Lys Glu Phe Ser Gly Pro Gly150 155 160 165aaa gcg cag cgt gcc gta gaa atg ctg ggc aat ctg tgg aag atc ggc 643Lys Ala Gln Arg Ala Val Glu Met Leu Gly Asn Leu Trp Lys Ile Gly

170 175 180gtg gtg gtg agt agg aat acg gaa agt cgc ctt ggg tta act cgt gtg 691Val Val Val Ser Arg Asn Thr Glu Ser Arg Leu Gly Leu Thr Arg Val

185 190 195gaa tac acc ccc acc cct ggc gaa gta ccc gtg ccg ctg atg tcg gag 739Glu Tyr Thr Pro Thr Pro Gly Glu Val Pro Val Pro Leu Met Ser Glu

200 205 210aag aac tgt tgg tac agc att cgg gtg tct gaa acc att ggt gag aac 787Lys Asn Cys Trp Tyr Ser Ile Arg Val Ser Glu Thr Ile Gly Glu Asn

215 220 225cag gtt ccg gaa att gtg cgc tgc tta ggc gag att ttc tgt ggc tat 835Gln Val Pro Glu Ile Val Arg Cys Leu Gly Glu Ile Phe Cys Gly Tyr230 235 240 245ctt ccc cag atg tgg ctc aaa gaa cca gta aag gcc ggc aag ttg cga 883Leu Pro Gln Met Trp Leu Lys Glu Pro Val Lys Ala Gly Lys Leu Arg

250 255 260atc caa gaa tcg gaa gca gca gcg tat atc gcg atg gcg cga cta gat 931Ile Gln Glu Ser Glu Ala Ala Ala Tyr Ile Ala Met Ala Arg Leu Asp

265 270 275ctt tcc cca cgc acc ggc aac acc act tgg acc aac agc tat att tcc 979Leu Ser Pro Arg Thr Gly Asn Thr Thr Trp Thr Asn Ser Tyr Ile Ser

280 285 290acg cgt cct ctc tcc ccc gct ttt agg tgg gac gtg gtg ctg gag gct 1027Thr Arg Pro LeuSer Pro Ala Phe Arg Trp Asp Val Val Leu Glu Ala

295 300 305tcc cac caa ttg gag aac ctg ctg cgt gga gac aca ggg ccg gtc act 1075Ser His Gln Leu Glu Asn Leu Leu Arg Gly Asp Thr Gly Pro Val Thr310 315 320 325gcc aca caa tcg gca gct ggt taaccaaaag ttcacgtgga gat 1119Ala Thr Gln Ser Ala Ala Gly

330<210>122<211>332<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>122Met Asn Asp Phe Glu Thr Thr Ile Asp Arg Ile Ser Lys Glu Gln Asp 151015 Pro Ala Ala Arg Ser Arg Val Glu Gln Phe Ile Val Glu Thr Val Arg

20 25 30Ala Leu Pro Asn Leu Thr Thr Lys Gln Gly Ala Ser Leu Ala Ile Gln

35 40 45Leu Leu Asp Ala Val Gln Leu Ala Asp Ala Ala Gly Thr Lys Gly Gly

50 55 60Ala Ser Thr Ser Asn Ala Ser Ser Leu Pro Asp Thr Phe Asp Ala Leu 65 70 75 80Thr Ser Leu Ile Gly Lys Leu Asp Val Arg Ser Asp Ser Glu Trp Arg

85 90 95Ser Phe Gly Phe Gln Pro Ser Glu Thr Ala His Pro Leu Met Ile Ala

100 105 110Ile Pro Glu Ile Glu Ile Phe Tyr Gln His Thr Asp Val Glu Pro Gly

115 120 125Ser Asp Asp Ala Val Ala Pro Asp Phe Gln Glu Asn Gln Asp Met Trp

130 135 140Arg Arg Arg Leu Gly Ser Val Thr Glu Pro Asn Leu Ile Tyr Lys Glu145 150 155 160Phe Ser Gly Pro Gly Lys Ala Gln Arg Ala Val Glu Met Leu Gly Asn

165 170 175Leu Trp Lys Ile Gly Val Val Val Ser Arg Asn Thr Glu Ser Arg Leu

180 185 190Gly Leu Thr Arg Val Glu Tyr Thr Pro Thr Pro Gly Glu Val Pro Val

195 200 205Pro Leu Met Ser Glu Lys Asn Cys Trp Tyr Ser Ile Arg Val Ser Glu

210 215 220Thr Ile Gly Glu Asn Gln Val Pro Glu Ile Val Arg Cys Leu Gly Glu225 230 235 240Ile Phe Cys Gly Tyr Leu Pro Gln Met Trp Leu Lys Glu Pro Val Lys

245 250 255Ala Gly Lys Leu Arg Ile Gln Glu Ser Glu Ala Ala Ala Tyr Ile Ala

260 265 270Met Ala Arg Leu Asp Leu Ser Pro Arg Thr Gly Asn Thr Thr Trp Thr

275 280 285Asn Ser Tyr Ile Ser Thr Arg Pro Leu Ser Pro Ala Phe Arg Trp Asp

290 295 300Val Val Leu Glu Ala Ser His Gln Leu Glu Asn Leu Leu Arg Gly Asp305 310 315 320Thr Gly Pro Val Thr Ala Thr Gln Ser Ala Ala Gly

325330<210>123<211>1462<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1462)<223>RXN03110<400>123aatgagtgaa cctgcgcttg aactataccc cctggggtat tactgtagat tctcaatacc 60ccgaggggta tctagttttt acgttgagaa ggagagctca gtg ctt att gaa cgc 115

Val Leu Ile Glu Arg

1 5atc tac gac gaa gac ctt gcg cag gcc agc tat ttcatt ggc tgc caa 163Ile Tyr Asp Glu Asp Leu Ala Gln Ala Ser Tyr Phe Ile Gly Cys Gln

10 15 20gcc cac aac acc gca gtc gtg gtt gat ccg cgt cgc gat att gcc gtc 211Ala His Asn Thr Ala Val Val Val Asp Pro Arg Arg Asp Ile Ala Val

25 30 35tat ctg gac atg gcc aag aaa aac gga atg gag att gtt gga gtt acc 259Tyr Leu Asp Met Ala Lys Lys Asn Gly Met Glu Ile Val Gly Val Thr

40 45 50gaa acc cat atc cat gcg gac tat ttg tca gga acc cgt gag tta gct 307Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly Thr Arg Glu Leu Ala

55 60 65gct gca act aat gcc acc atg tac gtc tca ggg gag ggc ggc gcc gat 355Ala Ala Thr Asn Ala Thr Met Tyr Val Ser Gly Glu Gly Gly Ala Asp 70 75 80 85tgg cag tat gaa ttc gac gcc gag cga ata tgc gac ggc agc gag att 403Trp Gln Tyr Glu Phe Asp Ala Glu Arg Ile Cys Asp Gly Ser Glu Ile

90 95 100cgc ctg gga aat ctg gtg ctc aca gct gtt cac acc cca ggc cat acc 451Arg Leu Gly Asn Leu Val Leu Thr Ala Val His Thr Pro Gly His Thr

105 110 115ccg gaa cac tta tcg ttc ctg ctg aag gac ggc gcg ttc gca gat gag 499Pro Glu His Leu Ser Phe Leu Leu Lys Asp Gly Ala Phe Ala Asp Glu

120 125 130cca gga ttc atg ctc act ggc gat ttc gtt ttc gcg ggt gat crt ggc 547Pro Gly Phe Met Leu Thr Gly Asp Phe Val Phe Ala Gly Asp Leu Gly

135 140 145cga cca gat ttg ctc gat gaa gca gct ggg gga gtg gac act cgt ttt 595Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly Val Asp Thr Arg Phe150 155160 165gag ggg gct cgc caa atg ttc aag agc ttg aag gaa aaa ttc ctg aca 643Glu Gly Ala Arg Gln Met Phe Lys Ser Leu Lys Glu Lys Phe Leu Thr

170 175 180ttg cct gat cac atc cag atc ttc cct ggt cat ggt tcc ggt tcc gcg 691Leu Pro Asp His Ile Gln Ile Phe Pro Gly His Gly Ser Gly Ser Ala

185 190 195tgt ggc aaa gcc ttg ggt tcg gtt cct tca aca aca ctt gga tat gaa 739Cys Gly Lys Ala Leu Gly Ser Val Pro Ser Thr Thr Leu Gly Tyr Glu

200 205 210cgt caa ttt gcg tgg tgg gga aag tat ctg gag gca gat gat gaa caa 787Arg Gln Phe Ala Trp Trp Gly Lys Tyr Leu Glu Ala Asp Asp Glu Gln

215 220 225gga ttc att gat gag ctt ctg gaa ggc caa cct gat gca cct gca tac 835Gly Phe Ile Asp Glu Leu Leu Glu Gly Gln Pro Asp Ala Pro Ala Tyr230 235 240 245ttc ggc agg atg aag agg caa aat agg caa ggg ccc gca att atg ggc 883Phe Gly Arg Met Lys Arg Gln Asn Arg Gln Gly Pro Ala Ile Met Gly

250 255 260gct cgc gag ctg ttg cca cag ctg gaa gct tct gat ctg cac gac gtc 931Ala Arg Glu Leu Leu Pro Gln Leu Glu Ala Ser Asp Leu His Asp Val

265 270 275att gtt gtt gat acc cgc tca gcc gat gaa gtt cac cag ggc act gta 979Ile Val Val Asp Thr Arg Ser Ala Asp Glu Val His Gln Gly Thr Val

280 285 290gct ggt gca gtg aat att cct gcg ggc aat tcg atg gcg aaa ttt ggc 1027Ala Gly Ala Val Asn Ile Pro Ala Gly Asn Ser Met Ala Lys Phe Gly

295 300 305tcg tgg acc gtt gat ccc gag aag gat tcc cga gct ttg gtt ctg ctc 1075Ser Trp Thr Val Asp Pro Glu Lys Asp Ser Arg Ala Leu Val Leu Leu310 315 320 325gcg gca agc caa att ggt gcc atg gag atg tgg gac cac atg gtt cgc 1123Ala Ala Ser Gln Ile Gly Ala Met Glu Met Trp Asp His Met Val Arg

330 335 340gtg gga atc gat aat gtt gct ggt ttt atc acc aac ttt gat ggg gtg 1171Val Gly Ile Asp Asn Val Ala Gly Phe Ile Thr Asn Phe Asp Gly Val

345 350 355gac cta gtt gca ccg caa act gtg tcc cca gat cag ctg gat gaa ttg 1219Asp Leu Val Ala Pro Gln Thr Val Ser Pro Asp Gln Leu Asp Glu Leu

360 365 370gaa tac gat cta ctt ctt gat gtc cgc aac cgc agt gaa gtc gaa gaa 1267Glu Tyr Asp Leu Leu Leu Asp Val Arg Asn Arg Ser Glu Val Glu Glu

375 380 385ggc tac atc cca gga gca ctc cat att aat ggt gca tcc gtg ctg tgg 1315Gly Tyr Ile Pro Gly Ala Leu His Ile Asn Gly Ala Ser Val Leu Trp390 395 400 405aat ctg gag aaa ctg cca cgt gac gga aag atc gtg agc tac tgc aag 1363Asn Leu Glu Lys Leu Pro Arg Asp Gly Lys Ile Val Ser Tyr Cys Lys

410 415 420agt gga aca cgc agc tca atc gcc gca agc acc ctg cgt aat gct ggt 1411Ser Gly Thr Arg Ser Ser Ile Ala Ala Ser Thr Leu Arg Asn Ala Gly

425 430 435ttt gat gtg gtg gaa ctt caa gga tcc tat gac aac tgg gtc cgg cac 1459Phe Asp Val Val Glu Leu Gln Gly Ser Tyr Asp Asn Trp Val Arg His

440445450 aac1462Asn<210>124<211>454<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>124Val Leu Ile Glu Arg Ile Tyr Asp Glu Asp Leu Ala Gln Ala Ser Tyr 151015 Phe Ile Gly Cys Gln Ala His Asn Thr Ala Val Val Val Asp Pro Arg

20 25 30Arg Asp Ile Ala Val Tyr Leu Asp Met Ala Lys Lys Asn Gly Met Glu

35 40 45Ile Val Gly Val Thr Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly

50 55 60Thr Arg Glu Leu Ala Ala Ala Thr Asn Ala Thr Met Tyr Val Ser Gly 65 70 75 80Glu Gly Gly Ala Asp Trp Gln Tyr Glu Phe Asp Ala Glu Arg Ile Cys

85 90 95Asp Gly Ser Glu Ile Arg Leu Gly Asn Leu Val Leu Thr Ala Val His

100 105 110Thr Pro Gly His Thr Pro Glu His Leu Ser Phe Leu Leu Lys Asp Gly

115 120 125Ala Phe Ala Asp Glu Pro Gly Phe Met Leu Thr Gly Asp Phe Val Phe

130 135 140Ala Gly Asp Leu Gly Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly145 150 155 160Val Asp Thr Arg Phe Glu Gly Ala Arg Gln Met Phe Lys Ser Leu Lys

165 170 175Glu Lys Phe Leu Thr Leu Pro Asp His Ile Gln Ile Phe Pro Gly His

180 185 190Gly Ser Gly Ser Ala Cys Gly Lys Ala Leu Gly Ser Val Pro Ser Thr

195 200 205Thr Leu Gly Tyr Glu Arg Gln Phe Ala Trp Trp Gly Lys Tyr Leu Glu

210 215 220Ala Asp Asp Glu Gln Gly Phe Ile Asp Glu Leu Leu Glu Gly Gln Pro225 230 235 240Asp Ala Pro Ala Tyr Phe Gly Arg Met Lys Arg Gln Asn Arg Gln Gly

245 250 255Pro Ala Ile Met Gly Ala Arg Glu Leu Leu Pro Gln Leu Glu Ala Ser

260 265 270Asp Leu His Asp Val Ile Val Val Asp Thr Arg Ser Ala Asp Glu Val

275 280 285His Gln Gly Thr Val Ala Gly Ala Val Asn Ile Pro Ala Gly Asn Ser

290 295 300Met Ala Lys Phe Gly Ser Trp Thr Val Asp Pro Glu Lys Asp Ser Arg305 310 315 320Ala Leu Val Leu Leu Ala Ala Ser Gln Ile Gly Ala Met Glu Met Trp

325 330 335Asp His Met Val Arg Val Gly Ile Asp Asn Val Ala Gly Phe Ile Thr

340 345 350Asn Phe Asp Gly Val Asp Leu Val Ala Pro Gln Thr Val Ser Pro Asp

355 360 365Gln Leu Asp Glu Leu Glu Tyr Asp Leu Leu Leu Asp Val Arg Asn Arg

370 375 380Ser Glu Val Glu Glu Gly Tyr Ile Pro Gly Ala Leu His Ile Asn Gly385 390 395 400Ala Ser Val Leu Trp Asn Leu Glu Lys Leu Pro Arg Asp Gly Lys Ile

405 410 415Val Ser Tyr Cys Lys Ser Gly Thr Arg Ser Ser Ile Ala Ala Ser Thr

420 425 430Leu Arg Asn Ala Gly Phe Asp Val Val Glu Leu Gln Gly Ser Tyr Asp

435 440 445Asn Trp Val Arg His Asn

450<210>125<211>1023<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (1023)<223>FRXA00660<400>125cca ggc cat acc ccg gaa cac tta tcg ttc ctg ctg aag gac ggc gcg 48Pro Gly His Thr Pro Glu His Leu Ser Phe Leu Leu Lys Asp Gly Ala 151015 ttc gca cat gag cca gga ttc atg ctc act ggc gat ttc gtt ttc gcg 96Phe Ala His Glu Pro Gly Phe Met Leu Thr Gly Asp Phe Val Phe Ala

20 25 30ggt gat ctt ggc cga cca gat ttg ctc gat gaa gca gct ggg gga gtg 144Gly Asp Leu Gly Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly Val

35 40 45gac act cgt ttt gag ggg gct cgc caa atg ttc aag agc ttg aag gaa 192Asp Thr Arg Phe Glu Gly Ala Arg Gln Met Phe Lys Ser Leu Lys Glu

50 55 60aaa ttc ctg aca ttg cct gat cac atc cag atc ttc cct ggt cat ggt 240Lys Phe Leu Thr Leu Pro Asp His Ile Gln Ile Phe Pro Gly His Gly 65 70 75 80tcc ggt tcc gcg tgt ggc aaa gcc ttg ggt tcg gtt cct tca aca aca 288Ser Gly Ser Ala Cys Gly Lys Ala Leu Gly Ser Val Pro Ser Thr Thr

85 90 95ctt gga tat gaa cgt caa ttt gcg tgg tgg gga aag tat ctg gag gca 336Leu Gly Tyr Glu Arg Gln Phe Ala Trp Trp Gly Lys Tyr Leu Glu Ala

100 105 110gat gat gaa caa gga ttc att gat gag ctt ctg gaa ggc caa cct gat 384Asp Asp Glu Gln Gly Phe Ile Asp Glu Leu Leu Glu Gly Gln Pro Asp

115 120 125gca cct gca tac ttc ggc agg atg aag agg caa aat agg caa ggg ccc 432Ala Pro Ala Tyr Phe Gly Arg Met Lys Arg Gln Asn Arg Gln Gly Pro

130 135 140gca att atg ggc gct cgc gag ctg ttg cca cag ctg gaa gct tct gat 480Ala Ile Met Gly Ala Arg Glu Leu Leu Pro Gln Leu Glu Ala Ser Asp145 150 155 160ctg cac gac gtc att gtt gtt gat acc cgc tca gcc gat gaa gtt cac 528Leu His Asp Val Ile Val Val Asp Thr Arg Ser Ala Asp Glu Val His

165 170 175cag ggc act gta gct ggt gca gtg aat att cct gcg ggc aat tcg atg 576Gln Gly Thr Val Ala Gly Ala Val Asn Ile Pro Ala Gly Asn Ser Met

180 185 190gcg aaa ttt ggc tcg tgg acc gtt gat ccc gag aag gat tcc cga gct 624Ala Lys Phe Gly Ser Trp Thr Val Asp Pro Glu Lys Asp Ser Arg Ala

195 200 205ttg gtt ctg ctc gcg gca agc caa att ggt gcc atg gag atg tgg gac 672Leu Val Leu Leu Ala Ala Ser Gln Ile Gly Ala Met Glu Met Trp Asp

210 215 220cac atg gtt cgc gtg gga atc gat aat gtt gct ggt ttt atc acc aac 720His Met Val Arg Val Gly Ile Asp Asn Val Ala Gly Phe Ile Thr Asn225 230 235 240ttt gat ggg gtg gac cta gtt gca ccg caa act gtg tcc cca gat cag 768Phe Asp Gly Val Asp Leu Val Ala Pro Gln Thr Val Ser Pro Asp Gln

245 250 255ctg gat gaa ttg gaa tac gat cta ctt ctt gat gtc cgc aac cgc agt 816Leu Asp Glu Leu Glu Tyr Asp Leu Leu Leu Asp Val Arg Asn Arg Ser

260 265 270gaa gtc gaa gaa ggc tac atc cca gga gca ctc cat att aat ggt gca 864Glu Val Glu Glu Gly Tyr Ile Pro Gly Ala Leu His Ile Asn Gly Ala

275 280 285tcc gtg ctg tgg aat ctg gag aaa ctg cca cgt gac gga aag atc gtg 912Ser Val Leu Trp Asn Leu Glu Lys Leu Pro Arg Asp Gly Lys Ile Val

290 295300agc tac tgc aag agt gga aca cgc agc tca atc gcc gca agc acc ctg 960Ser Tyr Cys Lys Ser Gly Thr Arg Ser Ser Ile Ala Ala Ser Thr Leu305 310 315 320cgt aat gct ggt ttt gat gtg gtg gaa ctt caa gga tcc tat gac aac 1008Arg Asn Ala Gly Phe Asp Val Val Glu Leu Gln Gly Ser Tyr Asp Asn

325 330 335tgg gtc cgg cac aac 1023Trp Val Arg His Asn

340<210>126<211>341<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>126Pro Gly His Thr Pro Glu His Leu Ser Phe Leu Leu Lys Asp Gly Ala 151015 Phe Ala His Glu Pro Gly Phe Met Leu Thr Gly Asp Phe Val Phe Ala

20 25 30Gly Asp Leu Gly Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly Val

35 40 45Asp Thr Arg Phe Glu Gly Ala Arg Gln Met Phe Lys Ser Leu Lys Glu

50 55 60Lys Phe Leu Thr Leu Pro Asp His Ile Gln Ile Phe Pro Gly His Gly65 70 75 80Ser Gly Ser Ala Cys Gly Lys Ala Leu Gly Ser Val Pro Ser Thr Thr

85 90 95Leu Gly Tyr Glu Arg Gln Phe Ala Trp Trp Gly Lys Tyr Leu Glu Ala

100 105 110Asp Asp Glu Gln Gly Phe Ile Asp Glu Leu Leu Glu Gly Gln Pro Asp

115 120 125Ala Pro Ala Tyr Phe Gly Arg Met Lys Arg Gln Asn Arg Gln Gly Pro

130 135 140Ala Ile Met Gly Ala Arg Glu Leu Leu Pro Gln Leu Glu Ala Ser Asp145 150 155160Leu His Asp Val Ile Val Val Asp Thr Arg Ser Ala Asp Glu Val His

165 170 175Gln Gly Thr Val Ala Gly Ala Val Asn Ile Pro Ala Gly Asn Ser Met

180 185 190Ala Lys Phe Gly Ser Trp Thr Val Asp Pro Glu Lys Asp Ser Arg Ala

195 200 205Leu Val Leu Leu Ala Ala Ser Gln Ile Gly Ala Met Glu Met Trp Asp

210 215 220His Met Val Arg Val Gly Ile Asp Asn Val Ala Gly Phe Ile Thr Asn225 230 235 240Phe Asp Gly Val Asp Leu Val Ala Pro Gln Thr Val Ser Pro Asp Gln

245 250 255Leu Asp Glu Leu Glu Tyr Asp Leu Leu Leu Asp Val Arg Asn Arg Ser

260 265 270Glu Val Glu Glu Gly Tyr Ile Pro Gly Ala Leu His Ile Asn Gly Ala

275 280 285Ser Val Leu Trp Asn Leu Glu Lys Leu Pro Arg Asp Gly Lys Ile Val

290 295 300Ser Tyr Cys Lys Ser Gly Thr Arg Ser Ser Ile Ala Ala Ser Thr Leu305 310 315 320Arg Asn Ala Gly Phe Asp Val Val Glu Leu Gln Gly Ser Tyr Asp Asn

325 330 335Trp Val Arg His Asn

340<210>127<211>756<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (733)<223>RXA00801<400>127ggataagttt gtttctgagc gtattggtct tgatgatgtt gaagaggctt tcaacaccat 60gaaggctggc gacgtgctgc gttctgtggt ggagatctaa atg gct cac gac gga 115

Met Ala His Asp Gly

1 5ttg cgc gta gaa aac att gtc acc tca ggc atc ttt gcc ctt gat ggt 163Leu Arg Val Glu Asn Ile Val Thr Ser Gly Ile Phe Ala Leu Asp Gly

10 15 20ggc gaa tgg gaa gtc gac aac aac atc tgg gtt gtg gga aat gat gat 211Gly Glu Trp Glu Val Asp Asn Asn Ile Trp Val Val Gly Asn Asp Asp

25 30 35gag gtt ttc atc atc gat gcg gca cac act gca gca ccc atc atc gag 259Glu Val Phe Ile Ile Asp Ala Ala His Thr Ala Ala Pro Ile Ile Glu

40 45 50gct gtc ggt gga cgt gct gtg aag ggc att ttg tgc acc cac gca cac 307Ala Val Gly Gly Arg Ala Val Lys Gly Ile Leu Cys Thr His Ala His

55 60 65aat gac cac atc act gtc gca cca gag cta tcc aag gaa ttt gat gca 355Asn Asp His Ile Thr Val Ala Pro Glu Leu Ser Lys Glu Phe Asp Ala 70 75 80 85cca atc ttc gtg cac cca ggt gac caa atg ctg tgg gag gaa acc cac 403Pro Ile Phe Val His Pro Gly Asp Gln Met Leu Trp Glu Glu Thr His

90 95 100gga aac ctg acc cac gag gat ttg gca gat cag cag aag ttc caa atc 451Gly Asn Leu Thr His Glu Asp Leu Ala Asp Gln Gln Lys Phe Gln Ile

105 110 115gct gga act gaa ctg atc gtg ctt aat acc cct gga cac tca cct gga 499Ala Gly Thr Glu Leu Ile Val Leu Asn Thr Pro Gly His Ser Pro Gly

120 125 130tcc agc tgc ttc tac ctc cct gaa gca aac gag ctc ttc tct gga gac 547Ser Ser Cys Phe Tyr Leu Pro Glu Ala Asn Glu Leu Phe Ser Gly Asp

135 140 145act ttg ttc cag ggt ggg ccg gga gca act ggc cgt aag tac agc tcc 595Thr Leu Phe Gln Gly Gly Pro Gly Ala Thr Gly Arg Lys Tyr Ser Ser150 155 160 165ttt gac acc atc att gag tcc ctc aag acc tca att ttg gat cta cca 643Phe Asp Thr Ile Ile Glu Ser Leu Lys Thr Ser Ile Leu Asp Leu Pro

170 175 180gcg gaa acc acc gtg cgc act ggc cat ggt gat cac acc agt gtg ggg 691Ala Glu Thr Thr Val Arg Thr Gly His Gly Asp His Thr Ser Val Gly

185 190 195gct gag gct cca cac ttg gag gaa tgg att aaa cgc ggg cac 733Ala Glu Ala Pro His Leu Glu Glu Trp Ile Lys Arg Gly His

200205210 taagccccga acgat tagta ggc 756<210>128<211>211<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>128Met Ala His Asp Gly Leu Arg Val Glu Asn Ile Val Thr Ser Gly Ile 151015 Phe Ala Leu Asp Gly Gly Glu Trp Glu Val Asp Asn Asn Ile Trp Val

20 25 30Val Gly Asn Asp Asp Glu Val Phe Ile Ile Asp Ala Ala His Thr Ala

35 40 45Ala Pro Ile Ile Glu Ala Val Gly Gly Arg Ala Val Lys Gly Ile Leu

50 55 60Cys Thr His Ala His Asn Asp His Ile Thr Val Ala Pro Glu Leu Ser 65 70 75 80Lys Glu Phe Asp Ala Pro Ile Phe Val His Pro Gly Asp Gln Met Leu

85 90 95Trp Glu Glu Thr His Gly Asn Leu Thr His Glu Asp Leu Ala Asp Gln

100 105 110Gln Lys Phe Gln Ile Ala Gly Thr Glu Leu Ile Val Leu Asn Thr Pro

115 120 125Gly His Ser Pro Gly Ser Ser Cys Phe Tyr Leu Pro Glu Ala Asn Glu

130 135 140Leu Phe Ser Gly Asp Thr Leu Phe Gln Gly Gly Pro Gly Ala Thr Gly145 150 155 160Arg Lys Tyr Ser Ser Phe Asp Thr Ile Ile Glu Ser Leu Lys Thr Ser

165 170 175Ile Leu Asp Leu Pro Ala Glu Thr Thr Val Arg Thr Gly His Gly Asp

180 185 190His Thr Ser Val Gly Ala Glu Ala Pro His Leu Glu Glu Trp Ile Lys

195 200 205Arg Gly His

210<210>129<211>966<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (943)<223>RXA00821<400>129ttaaaagctt gcttctcgac gcaaaaaccc atccggcgca tcccttcaat gttaggggtg 60cgctgctatt tttctcccca gttctacgaa atgacttatt gtg act aag ctt gag 115

Val Thr Lys Leu Glu

1 5cgc atg gag cat cct gct tac agc caa ttg cgg ccg gtt acc ccg tcc 163Arg Met Glu His Pro Ala Tyr Ser Gln Leu Arg Pro Val Thr Pro Ser

10 15 20gca tct gtt gtt ttg tgc cct aat ccc ggt tac agc tcg ctg gaa ggc 211Ala Ser Val Val Leu Cys Pro Asn Pro Gly Tyr Ser Ser Leu Glu Gly

25 30 35act aat tct tgg gtt atc cgg gca cca gaa gac ccc cgg agc att gtc 259Thr Asn Ser Trp Val Ile Arg Ala Pro Glu Asp Pro Arg Ser Ile Val

40 45 50atc gat cca ggt cct gaa gat gag ggc cac ctt aac gtc ttg cat tcc 307Ile Asp Pro Gly Pro Glu Asp Glu Gly His Leu Asn Val Leu His Ser

55 60 65aag gct gag gag gtg ggt ttg att ctt ctg acc cac cgt cac tat gat 355Lys Ala Glu Glu Val Gly Leu Ile Leu Leu Thr His Arg His Tyr Asp 70 75 80 85cat gct gac ggc gca cag cgt ttc cgt cag ctg acc aat gca cct gtg 403His Ala Asp Gly Ala Gln Arg Phe Arg Gln Leu Thr Asn Ala Pro Val

90 95 100cgt gcg atg gac cct tcg tac tgt gct ggt gcg gag gag att cat gat 451Arg Ala Met Asp Pro Ser Tyr Cys Ala Gly Ala Glu Glu Ile His Asp

105 110 115ggt gag atc atc acg atc gac ggt gtc acc cca cag att gag gtg gtg 499Gly Glu Ile Ile Thr Ile Asp Gly Val Thr Pro Gln Ile Glu Val Val

120 125 130gcc aca cct ggt cat acc cgt gat tct gtg tct tat ttc atc tgg agt 547Ala Thr Pro Gly His Thr Arg Asp Ser Val Ser Tyr Phe Ile Trp Ser

135 140 145gga gtc cct cat gag tcc act ttg gag ggc atc gtt tct ggc gac acc 595Gly Val Pro His Glu Ser Thr Leu Glu Gly Ile Val Ser Gly Asp Thr150 155 160 165att gcg ggt cgt cac acc acg atg att tca gag acc gac ggc gat ttg 643Ile Ala Gly Arg His Thr Thr Met Ile Ser Glu Thr Asp Gly Asp Leu

170 175 180ggt gag tac ctg aat tct ttg gcc att ttg gag gag cgc ggc aag gat 691Gly Glu Tyr Leu Asn Ser Leu Ala Ile Leu Glu Glu Arg Gly Lys Asp

185 190 195att ccg ctg ctt cca gga cat ggt cca gat gga cag gac gtg tcc tcc 739Ile Pro Leu Leu Pro Gly His Gly Pro Asp Gly Gln Asp Val Ser Ser

200 205 210ttc gcg cgt aag tac att gag cgt cgt gag ctg cgt ctg aac cag atc 787Phe Ala Arg Lys Tyr Ile Glu Arg Arg Glu Leu Arg Leu Asn Gln Ile

215 220 225cgt gag gta tgg gag acc cgt ggc cgt gac gtg tcc atg aag gat ctc 835Arg Glu Val Trp Glu Thr Arg Gly Arg Asp Val Ser Met Lys Asp Leu230 235 240 245atc gac gcc atc tac gat gat gtt gat cca gtt ctg cgt ggt gca gcc 883Ile Asp Ala Ile Tyr Asp Asp Val Asp Pro Val Leu Arg Gly Ala Ala

250 255 260gag cag tcc act cat gtg gct att cgt tac ctg cag gct cag gaa gct 931Glu Gln Ser Thr His Val Ala Ile Arg Tyr Leu Gln Ala Gln Glu Ala

265 270 275tcc gcc tca aac taaacacttt taactaaaca aca 966Ser Ala Ser Asn

280<210>130<211>281<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>130Val Thr Lys Leu Glu Arg Met Glu His Pro Ala Tyr Ser Gln Leu Arg 151015 Pro Val Thr Pro Ser Ala Ser Val Val Leu Cys Pro Asn Pro Gly Tyr

20 25 30Ser Ser Leu Glu Gly Thr Asn Ser Trp Val Ile Arg Ala Pro Glu Asp

35 40 45Pro Arg Ser Ile Val Ile Asp Pro Gly Pro Glu Asp Glu Gly His Leu

50 55 60Asn Val Leu His Ser Lys Ala Glu Glu Val Gly Leu Ile Leu Leu Thr 65 70 75 80His Arg His Tyr Asp His Ala Asp Gly Ala Gln Arg Phe Arg Gln Leu

85 90 95Thr Asn Ala Pro ValArg Ala Met Asp Pro Ser Tyr Cys Ala Gly Ala

100 105 110Glu Glu Ile His Asp Gly Glu Ile Ile Thr Ile Asp Gly Val Thr Pro

115 120 125Gln Ile Glu Val Val Ala Thr Pro Gly His Thr Arg Asp Ser Val Ser

130 135 140Tyr Phe Ile Trp Ser Gly Val Pro His Glu Ser Thr Leu Glu Gly Ile145 150 155 160Val Ser Gly Asp Thr Ile Ala Gly Arg His Thr Thr Met Ile Ser Glu

165 170 175Thr Asp Gly Asp Leu Gly Glu Tyr Leu Asn Ser Leu Ala Ile Leu Glu

180 185 190Glu Arg Gly Lys Asp Ile Pro Leu Leu Pro Gly His Gly Pro Asp Gly

195 200 205Gln Asp Val Ser Ser Phe Ala Arg Lys Tyr Ile Glu Arg Arg Glu Leu

210 215 220Arg Leu Asn Gln Ile Arg Glu Val Trp Glu Thr Arg Gly Arg Asp Val225 230 235 240Ser Met Lys Asp Leu Ile Asp Ala Ile Tyr Asp Asp Val Asp Pro Val

245 250 255Leu Arg Gly Ala Ala Glu Gln Ser Thr His Val Ala Ile Arg Tyr Leu

260 265 270Gln Ala Gln Glu Ala Ser Ala Ser Asn

275280<210>131<211>1530<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1507)<223>RXN02966<400>131aaatataccc cccagggtat cttgacagat taaagctcga tgttttaggc tctacatata 60cccccacggg tatcccctca actttgatct aaggtgtcac atg ctt ttt gaa cgc 115

Met Leu Phe Glu Arg

1 5atc tac gaa gaa ggc ctc gcc caa gcc agc tat ttc att ggc tgc caa 163Ile Tyr Glu Glu Gly Leu Ala Gln Ala Ser Tyr Phe Ile Gly Cys Gln

10 15 20cgc gaa ggc aaa gcg att gtt gtt gat gct cgc cga gat atc cag acc 211Arg Glu Gly Lys Ala Ile Val Val Asp Ala Arg Arg Asp Ile Gln Thr

25 30 35tat ctg gac ctt gca gca aaa aac aac atg gtc att agc gcc gta acc 259Tyr Leu Asp Leu Ala Ala Lys Asn Asn Met Val Ile Ser Ala Val Thr

40 45 50gaa acc cat att cat gcc gat tat ctc tcc ggt act cgc gaa ctt gca 307Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly Thr Arg Glu Leu Ala

55 60 65gct gcc acc ggc gcc gag att ttc ctc tct ggc gaa ggc gga gct gat 355Ala Ala Thr Gly Ala Glu Ile Phe Leu Ser Gly Glu Gly Gly Ala Asp 70 75 80 85tgg caa tat ggc ttt aca ggc acc acc ttg atg cac aat tcc acc atc 403Trp Gln Tyr Gly Phe Thr Gly Thr Thr Leu Met His Asn Ser Thr Ile

90 95 100aag ctg gga aat atc acc atc aca gcc aag cac act ccc gga cac act 451Lys Leu Gly Asn Ile Thr Ile Thr Ala Lys His Thr Pro Gly His Thr

105 110 115cca gag cac ctg tca ttt ttg att act gat ggt gcg gtc tca aag gat 499Pro Glu His Leu Ser Phe Leu Ile Thr Asp Gly Ala Val Ser Lys Asp

120 125 130ccc ggt ttt atg ctc agc ggt gac ttc gtc ttc gta ggt gac gtg gga 547Pro Gly Phe Met Leu Ser Gly Asp Phe Val Phe Val Gly Asp Val Gly

135140 145cgt cca gat tta ctt gat gag gca gct ggc ggc gtg gac acc cgc ttc 595Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly Val Asp Thr Arg Phe150 155 160 165gcc gga gca cag caa ctc ttc cat agc cta aaa gag cag ttc ctt gca 643Ala Gly Ala Gln Gln Leu Phe His Ser Leu Lys Glu Gln Phe Leu Ala

170 175 180ctc ccc gac cac att cag gtt tat cca ggt cat ggt gct ggc agc cct 691Leu Pro Asp His Ile Gln Val Tyr Pro Gly His Gly Ala Gly Ser Pro

185 190 195tgt ggc aag gca ttg ggc gcg atc cct agc acc acc gtg gga tat gaa 739Cys Gly Lys Ala Leu Gly Ala Ile Pro Ser Thr Thr Val Gly Tyr Glu

200 205 210aag gct aat gcg tgg tgg gct cca tat ctg cgc agt gat gat gaa gcc 787Lys Ala Asn Ala Trp Trp Ala Pro Tyr Leu Arg Ser Asp Asp Glu Ala

215 220 225ggc ttt gtg gaa gag ctt ctc gac ggc cag cca gat gcc cac gct tac 835Gly Phe Val Glu Glu Leu Leu Asp Gly Gln Pro Asp Ala His Ala Tyr230 235 240 245ttt gct cgc atg aaa aag cag aac aag cag gga cct gca gta ctt agt 883Phe Ala Arg Met Lys Lys Gln Asn Lys Gln Gly Pro Ala Val Leu Ser

250 255 260aca tta tcc ccg ctt gtg aag cta gaa gcc gag gaa gtc gtc gaa aag 931Thr Leu Ser Pro Leu Val Lys Leu Glu Ala Glu Glu Val Val Glu Lys

265 270 275ctt ggt tct gaa gca gta ttt gtg gat acc cgc gag caa aac caa gtc 979Leu Gly Ser Glu Ala Val Phe Val Asp Thr Arg Glu Gln Asn Gln Val

280 285 290cat ctc gga acc gtt gtt ggg gca ttg aat att ccg cgc ggc gcc aag 1027His LeuGly Thr Val Val Gly Ala Leu Asn Ile Pro Arg Gly Ala Lys

295 300 305gcg tcc aat ttt gcg gcg tgg gtt att gat cct caa aag gat gct cag 1075Ala Ser Asn Phe Ala Ala Trp Val Ile Asp Pro Gln Lys Asp Ala Gln310 315 320 325gac ctt att gtt ttg gct ccg gac gcc aat acc gct gcg gat ttc cgc 1123Asp Leu Ile Val Leu Ala Pro Asp Ala Asn Thr Ala Ala Asp Phe Arg

330 335 340gac gct ttg ctg cgg gtt ggc atc gac act gtg cgt tat ttc acc aac 1171Asp Ala Leu Leu Arg Val Gly Ile Asp Thr Val Arg Tyr Phe Thr Asn

345 350 355agt atc gat gga ttg cct acc ttt gtg cca gaa ctc atc tcc ccc gct 1219Ser Ile Asp Gly Leu Pro Thr Phe Val Pro Glu Leu Ile Ser Pro Ala

360 365 370gag cta gct gag acc aac tat gac gca ctg att gat atc cgt gca aag 1267Glu Leu Ala Glu Thr Asn Tyr Asp Ala Leu Ile Asp Ile Arg Ala Lys

375 380 385tcc gaa ttt gcc gct ggc agc att ccc ggc gcg cag cag ctt tct gga 1315Ser Glu Phe Ala Ala Gly Ser Ile Pro Gly Ala Gln Gln Leu Ser Gly390 395 400 405ggt tcg gcc atg tgg cgc ctc aat gag ctg cct gcg ggt ggc act ttg 1363Gly Ser Ala Met Trp Arg Leu Asn Glu Leu Pro Ala Gly Gly Thr Leu

410 415 420gta acc ttc tgc caa tca gga gcg cga aat acc gtg gta gcc aat gct 1411Val Thr Phe Cys Gln Ser Gly Ala Arg Asn Thr Val Val Ala Asn Ala

425 430 435ttg cga cgc gcc gga ttc acc gtt atc gag ctc gag ggc agc tac gcc 1459Leu Arg Arg Ala Gly Phe Thr Val Ile Glu Leu Glu Gly Ser Tyr Ala

440445 450gcg tgg gaa aaa tca gct gcc aat cct aaa aac ttg cag act gcc gtc 1507Ala Trp Glu Lys Ser Ala Ala Asn Pro Lys Asn Leu Gln Thr Ala Val

455460465 tagttttaga tccggcgctg tat 1530<210>132<211>469<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>132Met Leu Phe Glu Arg Ile Tyr Glu Glu Gly Leu Ala Gln Ala Ser Tyr 151015 Phe Ile Gly Cys Gln Arg Glu Gly Lys Ala Ile Val Val Asp Ala Arg

20 25 30Arg Asp Ile Gln Thr Tyr Leu Asp Leu Ala Ala Lys Asn Asn Met Val

35 40 45Ile Ser Ala Val Thr Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly

50 55 60Thr Arg Glu Leu Ala Ala Ala Thr Gly Ala Glu Ile Phe Leu Ser Gly 65 70 75 80Glu Gly Gly Ala Asp Trp Gln Tyr Gly Phe Thr Gly Thr Thr Leu Met

85 90 95His Asn Ser Thr Ile Lys Leu Gly Asn Ile Thr Ile Thr Ala Lys His

100 105 110Thr Pro Gly His Thr Pro Glu His Leu Ser Phe Leu Ile Thr Asp Gly

115 120 125Ala Val Ser Lys Asp Pro Gly Phe Met Leu Ser Gly Asp Phe Val Phe

130 135 140Val Gly Asp Val Gly Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly145 150 155 160Val Asp Thr Arg Phe Ala Gly Ala Gln Gln Leu Phe His Ser Leu Lys

165 170 175Glu Gln Phe Leu Ala Leu Pro Asp His Ile Gln Val Tyr Pro Gly His

180 185 190Gly Ala Gly Ser Pro Cys Gly Lys Ala Leu Gly Ala Ile Pro Ser Thr

195 200 205Thr Val Gly Tyr Glu Lys Ala Asn Ala Trp Trp Ala Pro Tyr Leu Arg

210 215 220Ser Asp Asp Glu Ala Gly Phe Val Glu Glu Leu Leu Asp Gly Gln Pro225 230 235 240Asp Ala His Ala Tyr Phe Ala Arg Met Lys Lys Gln Asn Lys Gln Gly

245 250 255Pro Ala Val Leu Ser Thr Leu Ser Pro Leu Val Lys Leu Glu Ala Glu

260 265 270Glu Val Val Glu Lys Leu Gly Ser Glu Ala Val Phe Val Asp Thr Arg

275 280 285Glu Gln Asn Gln Val His Leu Gly Thr Val Val Gly Ala Leu Asn Ile

290 295 300Pro Arg Gly Ala Lys Ala Ser Asn Phe Ala Ala Trp Val Ile Asp Pro305 310 315 320Gln Lys Asp Ala Gln Asp Leu Ile Val Leu Ala Pro Asp Ala Asn Thr

325 330 335Ala Ala Asp Phe Arg Asp Ala Leu Leu Arg Val Gly Ile Asp Thr Val

340 345 350Arg Tyr Phe Thr Asn Ser Ile Asp Gly Leu Pro Thr Phe Val Pro Glu

355 360 365Leu Ile Ser Pro Ala Glu Leu Ala Glu Thr Asn Tyr Asp Ala Leu Ile

370 375 380Asp Ile Arg Ala Lys Ser Glu Phe Ala Ala Gly Ser Ile Pro Gly Ala385 390 395 400Gln Gln Leu Ser Gly Gly Ser Ala Met Trp Arg Leu Asn Glu Leu Pro

405 410 415Ala Gly Gly Thr Leu Val Thr Phe Cys Gln Ser Gly Ala Arg Asn Thr

420 425 430Val Val Ala Asn Ala Leu Arg Arg Ala Gly Phe Thr Val Ile Glu Leu

435 440 445Glu Gly Ser Tyr Ala Ala Trp Glu Lys Ser Ala Ala Asn Pro Lys Asn

450455460 Leu Gln Thr Ala Val465<210>133<211>1530<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1507)<223>FRXA01833<400>133aaatataccc cccagggtat cttgacagat taaagctcga tgttttaggc tctacatata 60cccccacggg tatcccctca actttgatct aaggtgtcac atg crt ttt gaa cgc 115

Met Leu Phe Glu Arg

1 5atc tac gaa gaa ggc ctc gcc caa gcc agc tat ttc att ggc tgc caa 163Ile Tyr Glu Glu Gly Leu Ala Gln Ala Ser Tyr Phe Ile Gly Cys Gln

10 15 20cgc gaa ggc aaa gcg att gtt gtt gat gct cgc cga gat atc cag acc 211Arg Glu Gly Lys Ala Ile Val Val Asp Ala Arg Arg Asp Ile Gln Thr

25 30 35tat ctg gac ctt gca gca aaa aac aac atg gtc att agc gcc gta acc 259Tyr Leu Asp Leu Ala Ala Lys Asn Asn Met Val Ile Ser Ala Val Thr

40 45 50gaa acc cat att cat gcc gat tat ctc tcc ggt act cgc gaa ctt gca 307Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly Thr Arg Glu Leu Ala

55 60 65gct gcc acc ggc gcc gag att ttc ctc tct ggc gaa ggc gga gct gat 355Ala Ala Thr Gly Ala Glu Ile Phe Leu Ser Gly Glu Gly Gly Ala Asp 70 75 80 85tgg caa tat ggc ttt aca ggc acc acc ttg atg cacaat tcc acc atc 403Trp Gln Tyr Gly Phe Thr Gly Thr Thr Leu Met His Asn Ser Thr Ile

90 95 100aag ctg gaa aat atc acc atc aca gcc aag cac act ccc gga cac act 451Lys Leu Glu Asn Ile Thr Ile Thr Ala Lys His Thr Pro Gly His Thr

105 110 115cca gag cac ctg tca ttt ttg att act gat ggt gcg gtc tca aag gat 499Pro Glu His Leu Ser Phe Leu Ile Thr Asp Gly Ala Val Ser Lys Asp

120 125 130ccc ggt ttt atg ctc agc ggt gac ttc gtc ttc gta ggt gac gtg gga 547Pro Gly Phe Met Leu Ser Gly Asp Phe Val Phe Val Gly Asp Val Gly

135 140 145cgt cca gat tta ctt gat gag gca gct ggc ggc gtg gac acc cgc ttc 595Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly Val Asp Thr Arg Phe150 155 160 165gcc gga gca cag caa ctc ttc cat agc cta aaa gag cag ttc ctt gca 643Ala Gly Ala Gln Gln Leu Phe His Ser Leu Lys Glu Gln Phe Leu Ala

170 175 180ctc ccc gac cac att cag gtt tat cca ggt cat ggt gct ggc agc cct 691Leu Pro Asp His Ile Gln Val Tyr Pro Gly His Gly Ala Gly Ser Pro

185 190 195tgt ggc aag gca ttg ggc gcg atc cct agc acc acc gtg gga tat gaa 739Cys Gly Lys Ala Leu Gly Ala Ile Pro Ser Thr Thr Val Gly Tyr Glu

200 205 210aag gct aat gcg tgg tgg gct cca tat ctg cgc agt gat gat gaa gcc 787Lys Ala Asn Ala Trp Trp Ala Pro Tyr Leu Arg Ser Asp Asp Glu Ala

215 220 225ggc ttt gtg gaa gag ctt ctc gac ggc cag cca gat gcc cac gct tac 835Gly Phe Val Glu Glu Leu Leu Asp Gly Gln Pro Asp Ala His Ala Tyr230235 240 245ttt gct cgc atg aaa aag cag aac aag cag gga cct gca gta ctt agt 883Phe Ala Arg Met Lys Lys Gln Asn Lys Gln Gly Pro Ala Val Leu Ser

250 255 260aca tta tcc ccg ctt gtg aag cta gaa gcc gag gaa gtc gtc gaa aag 931Thr Leu Ser Pro Leu Val Lys Leu Glu Ala Glu Glu Val Val Glu Lys

265 270 275ctt ggt tct gaa gca gta ttt gtg gat acc cgc gag caa aac caa gtc 979Leu Gly Ser Glu Ala Val Phe Val Asp Thr Arg Glu Gln Asn Gln Val

280 285 290cat ctc gga acc gtt gtt ggg gca ttg aat att ccg cgc ggc gcc aag 1027His Leu Gly Thr Val Val Gly Ala Leu Asn Ile Pro Arg Gly Ala Lys

295 300 305gcg tcc aat ttt gcg gcg tgg gtt att gat cct caa aag gat gct cag 1075Ala Ser Asn Phe Ala Ala Trp Val Ile Asp Pro Gln Lys Asp Ala Gln310 315 320 325gac ctt att gtt ttg gct ccg gac gcc aat acc gct gcg gat ttc cgc 1123Asp Leu Ile Val Leu Ala Pro Asp Ala Asn Thr Ala Ala Asp Phe Arg

330 335 340gac gct ttg ctg cgg gtt ggc atc gac act gtg cgt tat ttc acc aac 1171Asp Ala Leu Leu Arg Val Gly Ile Asp Thr Val Arg Tyr Phe Thr Asn

345 350 355agt atc gat gga ttg cct acc ttt gtg cca gaa ctc atc tcc ccc gct 1219Ser Ile Asp Gly Leu Pro Thr Phe Val Pro Glu Leu Ile Ser Pro Ala

360 365 370gag cta gct gag acc aac tat gac gca ctg att gat atc cgt gca aag 1267Glu Leu Ala Glu Thr Asn Tyr Asp Ala Leu Ile Asp Ile Arg Ala Lys

375 380 385tcc gaa ttt gcc gct ggc agc att ccc ggc gcg cag cag ctttct gga 1315Ser Glu Phe Ala Ala Gly Ser Ile Pro Gly Ala Gln Gln Leu Ser Gly390 395 400 405ggt tcg gcc atg tgg cgc ctc aat gag ctg cct gcg ggt ggc act ttg 1363Gly Ser Ala Met Trp Arg Leu Asn Glu Leu Pro Ala Gly Gly Thr Leu

410 415 420gta acc ttc tgc caa tca gga gcg cga aat acc gtg gta gcc aat gct 1411Val Thr Phe Cys Gln Ser Gly Ala Arg Asn Thr Val Val Ala Asn Ala

425 430 435ttg cga cgc gcc gga ttc acc gtt atc gag ctc gag ggc agc tac gcc 1459Leu Arg Arg Ala Gly Phe Thr Val Ile Glu Leu Glu Gly Ser Tyr Ala

440 445 450gcg tgg gaa aaa tca gct gcc aat cct aaa aac ttg cag act gcc gtc 1507Ala Trp Glu Lys Ser Ala Ala Asn Pro Lys Asn Leu Gln Thr Ala Val

455460465 tagttttaga tccggcgctg tat 1530<210>134<211>469<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>134Met Leu Phe Glu Arg Ile Tyr Glu Glu Gly Leu Ala Gln Ala Ser Tyr 151015 Phe Ile Gly Cys Gln Arg Glu Gly Lys Ala Ile Val Val Asp Ala Arg

20 25 30Arg Asp Ile Gln Thr Tyr Leu Asp Leu Ala Ala Lys Asn Asn Met Val

35 40 45Ile Ser Ala Val Thr Glu Thr His Ile His Ala Asp Tyr Leu Ser Gly

50 55 60Thr Arg Glu Leu Ala Ala Ala Thr Gly Ala Glu Ile Phe Leu Ser Gly 65 70 75 80Glu Gly Gly Ala Asp Trp Gln Tyr Gly Phe Thr Gly Thr Thr Leu Met

85 90 95His Asn Ser Thr Ile Lys Leu Glu Asn Ile Thr Ile Thr Ala Lys His

100 105 110Thr Pro Gly His Thr Pro Glu His Leu Ser Phe Leu Ile Thr Asp Gly

115 120 125Ala Val Ser Lys Asp Pro Gly Phe Met Leu Ser Gly Asp Phe Val Phe

130 135 140Val Gly Asp Val Gly Arg Pro Asp Leu Leu Asp Glu Ala Ala Gly Gly145 150 155 160Val Asp Thr Arg Phe Ala Gly Ala Gln Gln Leu Phe His Ser Leu Lys

165 170 175Glu Gln Phe Leu Ala Leu Pro Asp His Ile Gln Val Tyr Pro Gly His

180 185 190Gly Ala Gly Ser Pro Cys Gly Lys Ala Leu Gly Ala Ile Pro Ser Thr

195 200 205Thr Val Gly Tyr Glu Lys Ala Asn Ala Trp Trp Ala Pro Tyr Leu Arg

210 215 220Ser Asp Asp Glu Ala Gly Phe Val Glu Glu Leu Leu Asp Gly Gln Pro225 230 235 240Asp Ala His Ala Tyr Phe Ala Arg Met Lys Lys Gln Asn Lys Gln Gly

245 250 255Pro Ala Val Leu Ser Thr Leu Ser Pro Leu Val Lys Leu Glu Ala Glu

260 265 270Glu Val Val Glu Lys Leu Gly Ser Glu Ala Val Phe Val Asp Thr Arg

275 280 285Glu Gln Asn Gln Val His Leu Gly Thr Val Val Gly Ala Leu Asn Ile

290 295 300Pro Arg Gly Ala Lys Ala Ser Asn Phe Ala Ala Trp Val Ile Asp Pro305 310 315 320Gln Lys Asp Ala Gln Asp Leu Ile Val Leu Ala Pro Asp Ala Asn Thr

325 330 335Ala Ala Asp Phe Arg Asp Ala Leu Leu Arg Val Gly Ile Asp Thr Val

340 345 350Arg Tyr Phe Thr Asn Ser Ile Asp Gly Leu Pro Thr Phe Val Pro Glu

355 360 365Leu Ile Ser Pro Ala Glu Leu Ala Glu Thr Asn Tyr Asp Ala Leu Ile

370 375 380Asp Ile Arg Ala Lys Ser Glu Phe Ala Ala Gly Ser Ile Pro Gly Ala385 390 395 400Gln Gln Leu Ser Gly Gly Ser Ala Met Trp Arg Leu Asn Glu Leu Pro

405 410 415Ala Gly Gly Thr Leu Val Thr Phe Cys Gln Ser Gly Ala Arg Asn Thr

420 425 430Val Val Ala Asn Ala Leu Arg Arg Ala Gly Phe Thr Val Ile Glu Leu

435 440 445Glu Gly Ser Tyr Ala Ala Trp Glu Lys Ser Ala Ala Asn Pro Lys Asn

450455460 Leu Gln Thr Ala Val465<210>135<211>675<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<652><223>RXA01853<400>135gaatgtccaa cgtcaaaaaa attcttttct atcctaaccg tatcttcaca ccttgaggga 60atgatggggg agcgccgctt acgcactaca ctgtttattc atg gag atc ctc gga 115

Met Glu Ile Leu Gly

1 5ttc gcg gct ggt ccg tat aaa aca aat tgc tat gtg gtg cgc ggg gag 163Phe Ala Ala Gly Pro Tyr Lys Thr Asn Cys Tyr Val Val Arg Gly Glu

10 15 20aat gag gtc gcg atc att gat cct ggc atg cat gcc cac gat gat ttg 211Asn Glu Val Ala Ile Ile Asp Pro Gly Met His Ala His Asp Asp Leu

25 30 35gtg gaa tac atc acc acg aat aat ttg agc gtg gac aag att gtg ctc 259Val Glu Tyr Ile Thr Thr Asn Asn Leu Ser Val Asp Lys Ile Val Leu

40 45 50acc cac gga cac att gat cac acc cgt gat gct ggt gtt gtg gca aag 307Thr His Gly His Ile Asp His Thr Arg Asp Ala Gly Val Val Ala Lys

55 60 65cgt ttc aat gcg ccg gtc tat atc cat cct gat gat gcg ttt ttc ctt 355Arg Phe Asn Ala Pro Val Tyr Ile His Pro Asp Asp Ala Phe Phe Leu 70 75 80 85gag gtc tac aag gga tct gga aca aag acg gcc atg ctt ttc gac gcc 403Glu Val Tyr Lys Gly Ser Gly Thr Lys Thr Ala Met Leu Phe Asp Ala

90 95 100gac aac atg gtg tcc cct gat cct gag tca ctg cgt gat ctg gtt gat 451Asp Asn Met Val Ser Pro Asp Pro Glu Ser Leu Arg Asp Leu Val Asp

105 110 115ggt gag aca atc act ttg gct ggc gaa gaa ttc acg ttg aag cat gca 499Gly Glu Thr Ile Thr Leu Ala Gly Glu Glu Phe Thr Leu Lys His Ala

120 125 130cca ggg cat tca cct ggt tgt acg ctg atc gtc ggc aag gaa tac tgc 547Pro Gly His Ser Pro Gly Cys Thr Leu Ile Val Gly Lys Glu Tyr Cys

135 140 145ttt agc ggt gat gtg ttg ttc aag ggc tct att ggt cgc act gat ttt 595Phe Ser Gly Asp Val Leu Phe Lys Gly Ser Ile Gly Arg Thr Asp Phe150 155 160 165gag tgg tct gat gca gat gcc atg aat gag tca cta cgc acg gca gtg 643Glu Trp Ser Asp Ala Asp Ala Met Asn Glu Ser Leu Arg Thr Ala Val

170175180 ctc cca ctt tgatgatgca ttgcagattc ttc 675Leu Pro Leu<210>136<211>184<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>136Met Glu Ile Leu Gly Phe Ala Ala Gly Pro Tyr Lys Thr Asn Cys Tyr 151015 Val Val Arg Gly Glu Asn Glu Val Ala Ile Ile Asp Pro Gly Met His

20 25 30Ala His Asp Asp Leu Val Glu Tyr Ile Thr Thr Asn Asn Leu Ser Val

35 40 45Asp Lys Ile Val Leu Thr His Gly His Ile Asp His Thr Arg Asp Ala

50 55 60Gly Val Val Ala Lys Arg Phe Asn Ala Pro Val Tyr Ile His Pro Asp 65 70 75 80Asp Ala Phe Phe Leu Glu Val Tyr Lys Gly Ser Gly Thr Lys Thr Ala

85 90 95Met Leu Phe Asp Ala Asp Asn Met Val Ser Pro Asp Pro Glu Ser Leu

100 105 110Arg Asp Leu Val Asp Gly Glu Thr Ile Thr Leu Ala Gly Glu Glu Phe

115 120 125Thr Leu Lys His Ala Pro Gly His Ser Pro Gly Cys Thr Leu Ile Val

130 135 140Gly Lys Glu Tyr Cys Phe Ser Gly Asp Val Leu Phe Lys Gly Ser Ile145 150 155 160Gly Arg Thr Asp Phe Glu Trp Ser Asp Ala Asp Ala Met Asn Glu Ser

165 170 175Leu Arg Thr Ala Val Leu Pro Leu

180<210>137<211>723<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (700)<223>RXN02424<400>137agccaatgct caactgccct tcaaaatcga tttttgtcgc ttcaaaaaat acaccttcga 60acatagcatc gaacaaggtgtttccgctag tctgaaccac atg act aac gag ctc 115

Met Thr Asn Glu Leu

1 5act ctt cac cat att tcc gtg tcc caa atg gac aac aat tgc tac ctt 163Thr Leu His His Ile Ser Val Ser Gln Met Asp Asn Asn Cys Tyr Leu

10 15 20ttg gcc gca aat ggc aac ggt tta ctc att gat gct gca gat gac gca 211Leu Ala Ala Asn Gly Asn Gly Leu Leu Ile Asp Ala Ala Asp Asp Ala

25 30 35gct gca cta ctt aaa tta gcc gaa gat gcc ggt gtg acc atc acc aaa 259Ala Ala Leu Leu Lys Leu Ala Glu Asp Ala Gly Val Thr Ile Thr Lys

40 45 50gtg ttg acc acc cac cgc cac gca gac cac gtc cgt gca ttg ccg gag 307Val Leu Thr Thr His Arg His Ala Asp His Val Arg Ala Leu Pro Glu

55 60 65gtt ctc cag aag acc gga gca act cac tac gcg cct ttc ctt gag gtg 355Val Leu Gln Lys Thr Gly Ala Thr His Tyr Ala Pro Phe Leu Glu Val 70 75 80 85cca gct ttg ccc tcc gct gtt gat gtg gaa ctg cat cat ggt gat tca 403Pro Ala Leu Pro Ser Ala Val Asp Val Glu Leu His His Gly Asp Ser

90 95 100att gaa ttt gag ggt cat gta ttc cct atc agc att ctg cgc ggc cac 451Ile Glu Phe Glu Gly His Val Phe Pro Ile Ser Ile Leu Arg Gly His

105 110 115acc cca ggc ggt gca gta ctc acc gct gag atc gac ggt aaa act cac 499Thr Pro Gly Gly Ala Val Leu Thr Ala Glu Ile Asp Gly Lys Thr His

120 125 130ctt ttc gtg ggt gac agc ctc ttc ccc ggc ggt ttg ggc aaa acc agc 547Leu Phe Val Gly Asp SerLeu Phe Pro Gly Gly Leu Gly Lys Thr Ser

135 140 145agc gaa ggc gac ttc gtc cga ctg ttc aac gat gtc aaa gag cgc atc 595Ser Glu Gly Asp Phe Val Arg Leu Phe Asn Asp Val Lys Glu Arg Ile150 155 160 165ttt gac acc tac gac gat gac agc atc gtg tgg cca ggt cac ggc aag 643Phe Asp Thr Tyr Asp Asp Asp Ser Ile Val Trp Pro Gly His Gly Lys

170 175 180gaa acc acc ctt gga gcc gag cgt cca cag ctg gaa atc tgg tgg gag 691Glu Thr Thr Leu Gly Ala Glu Arg Pro Gln Leu Glu Ile Trp Trp Glu

185 190 195cgt cgc tgg taagcgcttt tctcaaccag gca 723Arg Arg Trp

200<210>138<211>200<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>138Met Thr Asn Glu Leu Thr Leu His His Ile Ser Val Ser Gln Met Asp 151015 Asn Asn Cys Tyr Leu Leu Ala Ala Asn Gly Asn Gly Leu Leu Ile Asp

20 25 30Ala Ala Asp Asp Ala Ala Ala Leu Leu Lys Leu Ala Glu Asp Ala Gly

35 40 45Val Thr Ile Thr Lys Val Leu Thr Thr His Arg His Ala Asp His Val

50 55 60Arg Ala Leu Pro Glu Val Leu Gln Lys Thr Gly Ala Thr His Tyr Ala 65 70 75 80Pro Phe Leu Glu Val Pro Ala Leu Pro Ser Ala Val Asp Val Glu Leu

85 90 95His His Gly Asp Ser Ile Glu Phe Glu Gly His Val Phe Pro Ile Ser

100 105 110Ile Leu Arg Gly His Thr Pro Gly Gly Ala Val Leu Thr Ala Glu Ile

115 120 125Asp Gly Lys Thr His Leu Phe Val Gly Asp Ser Leu Phe Pro Gly Gly

130 135 140Leu Gly Lys Thr Ser Ser Glu Gly Asp Phe Val Arg Leu Phe Asn Asp145 150 155 160Val Lys Glu Arg Ile Phe Asp Thr Tyr Asp Asp Asp Ser Ile Val Trp

165 170 175Pro Gly His Gly Lys Glu Thr Thr Leu Gly Ala Glu Arg Pro Gln Leu

180 185 190Glu Ile Trp Trp Glu Arg Arg Trp

195200<210>139<211>404<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (381)<223>FRXA02424<400>139acc gga gca act cac tac gcg cct ttc ctt gag gtg cca gct ttg ccc 48Thr Gly Ala Thr His Tyr Ala Pro Phe Leu Glu Val Pro Ala Leu Pro 151015 tcc gct gtt gat gtg gaa ctg cat cat ggt gat tca att gaa ttt gag 96Ser Ala Val Asp Val Glu Leu His His Gly Asp Ser Ile Glu Phe Glu

20 25 30ggt cat gta ttc cct atc agc att ctg cgc ggc cac acc cca ggc ggt 144Gly His Val Phe Pro Ile Ser Ile Leu Arg Gly His Thr Pro Gly Gly

35 40 45gca gta ctc acc gct gag atc gac ggt aaa act cac ctt ttc gtg ggt 192Ala Val Leu Thr Ala Glu Ile Asp Gly Lys Thr His Leu Phe Val Gly

50 55 60gac agc ctc ttc ccc ggc ggt ttg ggc aaa acc agc agc gaa ggc gac 240Asp Ser Leu Phe Pro Gly Gly Leu Gly Lys Thr Ser Ser Glu Gly Asp 65 70 75 80ttc gtc cga ctg ttc aac gat gtc aaa gag cgc atc ttt gac acc tac 288Phe Val Arg Leu Phe Asn Asp Val Lys Glu Arg Ile Phe Asp Thr Tyr

85 90 95gac gat gac agc atc gtg tgg cca ggt cac ggc aag gaa acc acc ctt 336Asp Asp Asp Ser Ile Val Trp Pro Gly His Gly Lys Glu Thr Thr Leu

100 105 110gga gcc gag cgt cca cag ctg gaa atc tgg tgg gag cgt cgc tgg 381Gly Ala Glu Arg Pro Gln Leu Glu Ile Trp Trp Glu Arg Arg Trp

115120125 taagcgcttt tctcaaccag gca 404<210>140<211>127<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>140Thr Gly Ala Thr His Tyr Ala Pro Phe Leu Glu Val Pro Ala Leu Pro 151015 Ser Ala Val Asp Val Glu Leu His His Gly Asp Ser Ile Glu Phe Glu

20 25 30Gly His Val Phe Pro Ile Ser Ile Leu Arg Gly His Thr Pro Gly Gly

35 40 45Ala Val Leu Thr Ala Glu Ile Asp Gly Lys Thr His Leu Phe Val Gly

50 55 60Asp Ser Leu Phe Pro Gly Gly Leu Gly Lys Thr Ser Ser Glu Gly Asp 65 70 75 80Phe Val Arg Leu Phe Asn Asp Val Lys Glu Arg Ile Phe Asp Thr Tyr

85 90 95Asp Asp Asp Ser Ile Val Trp Pro Gly His Gly Lys Glu Thr Thr Leu

100 105 110Gly Ala Glu Arg Pro Gln Leu Glu Ile Trp Trp Glu Arg Arg Trp

115120125<210>141<211>882<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (859)<223>RXN00419<400>141gctggttgaa gactcgaaat gagatcgacc caaccggagt ctttgcatct gacatgtccc 60gccgacttga gctttcttaa gaaagggctt gaactaaaca atg ctt aac gca gtg 115

Met Leu Asn Ala Val

1 5ggc aaa gcc caa aac att ctc ctt ctt ggt gga acc tct gag atc ggt 163Gly Lys Ala Gln Asn Ile Leu Leu Leu Gly Gly Thr Ser Glu Ile Gly

10 15 20att tcc att gtc tcc cgc ttc ctc aag cag ggt cca tcc cat gtg acc 211Ile Ser Ile Val Ser Arg Phe Leu Lys Gln Gly Pro Ser His Val Thr

25 30 35ttg gca gcg cgt aaa gat tcc cca cgc gtg gac gca gca gtc gca gag 259Leu Ala Ala Arg Lys Asp Ser Pro Arg Val Asp Ala Ala Val Ala Glu

40 45 50atc aaa gca gct ggc gct gct tcc gtt gct gtt gtt gat ttc gat gcg 307Ile Lys Ala Ala Gly Ala Ala Ser Val Ala Val Val Asp Phe Asp Ala

55 60 65ctc gac acc gaa tcc cac cct gca gcc atc gac gca gcc ttt gaa aac 355Leu Asp Thr Glu Ser His Pro Ala Ala Ile Asp Ala Ala Phe Glu Asn 70 75 80 85ggc gac gtt gac gta gca atc gtg gct ttc ggc atc ctc ggc gac aac 403Gly Asp Val Asp Val Ala Ile Val Ala Phe Gly Ile Leu Gly Asp Asn

90 95 100gaa gca cag tgg cgc gac caa gca cta gca gtg gaa gca acc acc gtg 451Glu Ala Gln Trp Arg Asp Gln Ala Leu Ala Val Glu Ala Thr Thr Val

105 110 115aac tac acc gcc ggc gtt tcc gta ggt gta ctg ctg ggc cag aaa ttt 499Asn Tyr Thr Ala Gly Val Ser Val Gly Val Leu Leu Gly Gln Lys Phe

120 125 130gag cag cag ggc cac ggc acc atc gtg gca ttg tcc tct gtg gca ggc 547Glu Gln Gln Gly His Gly Thr Ile Val Ala Leu Ser Ser Val Ala Gly

135 140 145cag cga gtc cgc cgc tcc aac ttt gtc tac ggc tcc gcc aag gca ggt 595Gln Arg Val Arg Arg Ser Asn Phe Val Tyr Gly Ser Ala Lys Ala Gly150 155 160 165ttc gac ggt ttc tac acc cag ctc ggc gaa gcc ctg cgt gga tcc ggt 643Phe Asp Gly Phe Tyr Thr Gln Leu Gly Glu Ala Leu Arg Gly Ser Gly

170 175 180gcc aac gta ttg gtg gtt cgc cca ggc cag gta cgc acc aag atg tcc 691Ala Asn Val Leu Val Val Arg Pro Gly Gln Val Arg Thr Lys Met Ser

185 190 195gca gat ggt ggc gaa gcc cca ctg acc gtc aac cgc gaa gac gtg gca 739Ala Asp Gly Gly Glu Ala Pro Leu Thr Val Asn Arg Glu Asp Val Ala

200 205 210gat gct gtt tat gat gca gtg gtg aac aag aag gac atc atc ttt gtc 787Asp Ala Val Tyr Asp Ala Val Val Asn Lys Lys Asp Ile Ile Phe Val

215 220 225cac cca ctg ttc cag tac gtc tct ttt gcg ttc caa ttc att ccg cga 835His Pro Leu Phe Gln Tyr Val Ser Phe Ala Phe Gln Phe Ile Pro Arg230 235 240 245gca atc ttc cgc aag ctg ccg ttc taacggaagt tacggaagtt acg 882Ala Ile Phe Arg Lys Leu Pro Phe

250<210>142<211>253<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>142Met Leu Asn Ala Val Gly Lys Ala Gln Asn Ile Leu Leu Leu Gly Gly 151015 Thr Ser Glu Ile Gly Ile Ser Ile Val Ser Arg Phe Leu Lys Gln Gly

20 25 30Pro Ser His Val Thr Leu Ala Ala Arg Lys Asp Ser Pro Arg Val Asp

35 40 45Ala Ala Val Ala Glu Ile Lys Ala Ala Gly Ala Ala SerVal Ala Val

50 55 60Val Asp Phe Asp Ala Leu Asp Thr Glu Ser His Pro Ala Ala Ile Asp 65 70 75 80Ala Ala Phe Glu Asn Gly Asp Val Asp Val Ala Ile Val Ala Phe Gly

85 90 95Ile Leu Gly Asp Asn Glu Ala Gln Trp Arg Asp Gln Ala Leu Ala Val

100 105 110Glu Ala Thr Thr Val Asn Tyr Thr Ala Gly Val Ser Val Gly Val Leu

115 120 125Leu Gly Gln Lys Phe Glu Gln Gln Gly His Gly Thr Ile Val Ala Leu

130 135 140Ser Ser Val Ala Gly Gln Arg Val Arg Arg Ser Asn Phe Val Tyr Gly145 150 155 160Ser Ala Lys Ala Gly Phe Asp Gly Phe Tyr Thr Gln Leu Gly Glu Ala

165 170 175Leu Arg Gly Ser Gly Ala Asn Val Leu Val Val Arg Pro Gly Gln Val

180 185 190Arg Thr Lys Met Ser Ala Asp Gly Gly Glu Ala Pro Leu Thr Val Asn

195 200 205Arg Glu Asp Val Ala Asp Ala Val Tyr Asp Ala Val Val Asn Lys Lys

210 215 220Asp Ile Ile Phe Val His Pro Leu Phe Gln Tyr Val Ser Phe Ala Phe225 230 235 240Gln Phe Ile Pro Arg Ala Ile Phe Arg Lys Leu Pro Phe

245250<210>143<211>485<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (462)<223>FRXA00419<400>143gac aac gaa gca cag tgg cgc gac caa gca cta gca gtg gaa gca acc 48Asp Asn Glu Ala Gln Trp Arg Asp Gln Ala Leu Ala Val Glu Ala Thr 151015 acc gtg aac tac acc gcc ggc gtt tcc gta ggt gta ctg ctg ggc cag 96Thr Val Asn Tyr Thr Ala Gly Val Ser Val Gly Val Leu Leu Gly Gln

20 25 30aaa ttt gag cag cag ggc cac ggc acc atc gtg gca ttg tcc tct gtg 144Lys Phe Glu Gln Gln Gly His Gly Thr Ile Val Ala Leu Ser Ser Val

35 40 45gca ggc cag cga gtc cgc cgc tcc aac ttt gtc tac ggc tcc gcc aag 192Ala Gly Gln Arg Val Arg Arg Ser Asn Phe Val Tyr Gly Ser Ala Lys

50 55 60gca ggt ttc gac ggt ttc tac acc cag ctc ggc gaa gcc ctg cgt gga 240Ala Gly Phe Asp Gly Phe Tyr Thr Gln Leu Gly Glu Ala Leu Arg Gly 65 70 75 80tcc ggt gcc aac gta ttg gtg gtt cgc cca ggc cag gta cgc acc aag 288Ser Gly Ala Asn Val Leu Val Val Arg Pro Gly Gln Val Arg Thr Lys

85 90 95atg tcc gca gat ggt ggc gaa gcc cca ctg acc gtc aac cgc gaa gac 336Met Ser Ala Asp Gly Gly Glu Ala Pro Leu Thr Val Asn Arg Glu Asp

100 105 110gtg gca gat gct gtt tat gat gca gtg gtg aac aag aag gac atc atc 384Val Ala Asp Ala Val Tyr Asp Ala Val Val Asn Lys Lys Asp Ile Ile

115 120 125ttt gtc cac cca ctg ttc cag tac gtc tct ttt gcg ttc caa ttc att 432Phe Val His Pro Leu Phe Gln Tyr Val Ser Phe Ala Phe Gln Phe Ile

130135140 ccg cga gca atc ttc cgc aag ctg ccg ttc taacggaagt tacggaagtt 482Pro Arg Ala Ile Phe Arg Lys Leu Pro Phe 145150 acg 485<210>144<211>154<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>144Asp Asn Glu Ala Gln Trp Arg Asp Gln Ala Leu AlaVal Glu Ala Thr 151015 Thr Val Asn Tyr Thr Ala Gly Val Ser Val Gly Val Leu Leu Gly Gln

20 25 30Lys Phe Glu Gln Gln Gly His Gly Thr Ile Val Ala Leu Ser Ser Val

35 40 45Ala Gly Gln Arg Val Arg Arg Ser Asn Phe Val Tyr Gly Ser Ala Lys

50 55 60Ala Gly Phe Asp Gly Phe Tyr Thr Gln Leu Gly Glu Ala Leu Arg Gly 65 70 75 80Ser Gly Ala Asn Val Leu Val Val Arg Pro Gly Gln Val Arg Thr Lys

85 90 95Met Ser Ala Asp Gly Gly Glu Ala Pro Leu Thr Val Asn Arg Glu Asp

100 105 110Val Ala Asp Ala Val Tyr Asp Ala Val Val Asn Lys Lys Asp Ile Ile

115 120 125Phe Val His Pro Leu Phe Gln Tyr Val Ser Phe Ala Phe Gln Phe Ile

130135140 Pro Arg Ala Ile Phe Arg Lys Leu Pro Phe 145150<210>145<211>259<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (259)<223>FRXA00421<400>145gctggttgaa gactcgaaat gagatcgacc caaccggagt ctttgcatct gacatgtccc 60gccgacttga gctttcttaa gaaagggctt gaactaaaca atg ctt aac gca gtg 115

Met Leu Asn Ala Val

1 5ggc aaa gcc caa aac att ctc ctt ctt ggt gga acc tct gag atc ggt 163Gly Lys Ala Gln Asn Ile Leu Leu Leu Gly Gly Thr Ser Glu Ile Gly

10 15 20att tcc att gtc tcc cgc ttc ctc aag cag ggt cca tcc cat gtg acc 211Ile Ser Ile Val Ser Arg Phe Leu Lys Gln Gly Pro Ser His Val Thr

25 30 35ttg gca gcg cgt aaa gat tcc cca cgc gtg gac gca gca gtc gca gag 259Leu Ala Ala Arg Lys Asp Ser Pro Arg Val Asp Ala Ala Val Ala Glu

404550<210>146<211>53<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>146Met Leu Asn Ala Val Gly Lys Ala Gln Asn Ile Leu Leu Leu Gly Gly 151015 Thr Ser Glu Ile Gly Ile Ser Ile Val Ser Arg Phe Leu Lys Gln Gly

20 25 30Pro Ser His Val Thr Leu Ala Ala Arg Lys Asp Ser Pro Arg Val Asp

35 40 45Ala Ala Val Ala Glu

50<210>147<211>861<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (838)<223>RXN02923<400>147gcatctacat tgaaggaatc cacggagcgc gcatcgaaga catcgttgtg gtgaatgaag 60acggttgtga aaccctcaac aaccagccca aggaactgcg ttg agc att ctt ctc 115

Leu Ser Ile Leu Leu

1 5cta ggc gga acc tct gac att gcc ggt gag att gcc acg ttg acg tgt 163Leu Gly Gly Thr Ser Asp Ile Ala Gly Glu Ile Ala Thr Leu Thr Cys

10 15 20cac ggc gaa gac gtt gtt ttg gct gct cgt cga cca gag gct gca cag 211His Gly Glu Asp Val Val Leu Ala Ala Arg Arg Pro Glu Ala Ala Gln

25 30 35ggc tta gcg gaa gat ctt cga cag cgc ggt gcc aca tct gtt cat gtt 259Gly Leu Ala Glu Asp Leu Arg Gln Arg Gly Ala Thr Ser Val His Val

40 45 50ttg agc ttt gac gcc caa gta cta gac acg cac cga gaa ctt gtg aag 307Leu Ser Phe Asp Ala Gln Val Leu Asp Thr His Arg Glu Leu Val Lys

55 60 65aaa aca caa gag cta gct ggc gag att tcc ctt gcc gtg gtt gct ttt 355Lys Thr Gln Glu Leu Ala Gly Glu Ile Ser Leu Ala Val Val Ala Phe 70 75 80 85ggc atc ttg gga gac caa gaa cgc gca gaa acc gat gag acc cat gcg 403Gly Ile Leu Gly Asp Gln Glu Arg Ala Glu Thr Asp Glu Thr His Ala

90 95 100gta gag atc gcc acc gtg gat tac acc gct cag gtc tcc atg ctc act 451Val Glu Ile Ala Thr Val Asp Tyr Thr Ala Gln Val Ser Met Leu Thr

105 110 115gtg ctt gct gat gag ctc cgc gca caa act act cca gca gcg atc gtg 499Val Leu Ala Asp Glu Leu Arg Ala Gln Thr Thr Pro Ala Ala Ile Val

120 125 130gcg ttt tcc tcg att gct ggg tgg cgg gcg cgc cgg cct aac tat gtc 547Ala Phe Ser Ser Ile Ala Gly Trp Arg Ala Arg Arg Pro Asn Tyr Val

135 140 145tat gga tcc acc aag gct ggt ctc gat gca ttt tgc caa ggg ctt gca 595Tyr Gly Ser Thr Lys Ala Gly Leu Asp Ala Phe Cys Gln Gly Leu Ala150 155 160 165gat agc ctg cat ggg aca cac gtg cga ttg att att gcg cgt cct ggc 643Asp Ser Leu His Gly Thr His Val Arg Leu Ile Ile Ala Arg Pro Gly

170 175 180ttt gtt att ggt tct atg acc acg ggg atg aag cct gct ccg atg tcg 691Phe Val Ile Gly Ser Met Thr Thr Gly Met Lys Pro Ala Pro Met Ser

185 190 195gtg tat cca cga gat gtt gcc gca gct gtt gtt agt gct tat acc tct 739Val Tyr Pro Arg Asp Val Ala Ala Ala Val Val Ser Ala Tyr Thr Ser

200 205 210aag aag agg agc acg acc ttg tgg att ccg gga cgt ctg cgg gtt ctc 787Lys Lys Arg Ser Thr Thr Leu Trp Ile Pro Gly Arg Leu Arg Val Leu

215220225 gcc tgg att atg cgg atg gtt cct cgt ccg gtg tgg cgg aag atg cca 835Ala Trp Ile Met Arg Met Val Pro Arg Pro Val Trp Arg Lys Met Pro 230235240245 cgc tagatacccg ttcagccctc aca 861Arg<210>148<211>246<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>148Leu Ser Ile Leu Leu Leu Gly Gly Thr Ser Asp Ile Ala Gly Glu Ile 151015 Ala Thr Leu Thr Cys His Gly Glu Asp Val Val Leu Ala Ala Arg Arg

20 25 30Pro Glu Ala Ala Gln Gly Leu Ala Glu Asp Leu Arg Gln Arg Gly Ala

35 40 45Thr Ser Val His Val Leu Ser Phe Asp Ala Gln Val Leu Asp Thr His

50 55 60Arg Glu Leu Val Lys Lys Thr Gln Glu Leu Ala Gly Glu Ile Ser Leu 65 70 75 80Ala Val Val Ala Phe Gly Ile Leu Gly Asp Gln Glu Arg Ala Glu Thr

85 90 95Asp Glu Thr His Ala Val Glu Ile Ala Thr Val Asp Tyr Thr Ala Gln

100 105 110Val Ser Met Leu Thr Val Leu Ala Asp Glu Leu Arg Ala Gln Thr Thr

115 120 125Pro Ala Ala Ile Val Ala Phe Ser Ser Ile Ala Gly Trp Arg Ala Arg

130 135 140Arg Pro Asn Tyr Val Tyr Gly Ser Thr Lys Ala Gly Leu Asp Ala Phe145 150 155 160Cys Gln Gly Leu Ala Asp Ser Leu His Gly Thr His Val Arg Leu Ile

165 170 175Ile Ala Arg Pro Gly Phe Val Ile Gly Ser Met Thr Thr Gly Met Lys

180 185 190Pro Ala Pro Met Ser Val Tyr Pro Arg Asp Val Ala Ala Ala Val Val

195 200 205Ser Ala Tyr Thr Ser Lys Lys Arg Ser Thr Thr Leu Trp Ile Pro Gly

210 215 220Arg Leu Arg Val Leu Ala Trp Ile Met Arg Met Val Pro Arg Pro Val225 230 235 240Trp Arg Lys Met Pro Arg

245<210>149<211>1203<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1180)<223>RXN02922<400>149cccaccgcgg cgcaagctac cgcctaggcg ctcggaactc caccgccact attgatctca 60gttccatatc cgcccaacta gtttcccagg gagcccactc atg atc tca ccg caa 115

Met Ile Ser Pro Gln

1 5aca atc atc gac aat ctt gct cca gtc ctc gcg gag atc gca gca acg 163Thr Ile Ile Asp Asn Leu Ala Pro Val Leu Ala Glu Ile Ala Ala Thr

10 15 20gct gcg cag cgc gaa cag gat cga gaa ttc agc cgt gat ttg gca aag 211Ala Ala Gln Arg Glu Gln Asp Arg Glu Phe Ser Arg Asp Leu Ala Lys

25 30 35cag ctt agt gcc ggt ggg ttc act aaa ctc cgc att cca gtt gaa ttt 259Gln Leu Ser Ala Gly Gly Phe Thr Lys Leu Arg Ile Pro Val Glu Phe

40 45 50ggc ggt ttg ggt ttt agc ctt cca gaa gca ttt gag gtg ctg gtg gca 307Gly Gly Leu Gly Phe Ser Leu Pro Glu Ala Phe Glu Val Leu Val Ala

55 60 65gcg gcc gct gca gat tca aat atc gcg cag gga ttg cgg cct cac ttc 355Ala Ala Ala Ala Asp Ser Asn Ile Ala Gln Gly Leu Arg Pro His Phe 70 75 80 85ttg gca gtg gag agc tta ttg atc gct cct tat tca gag cac cgc acc 403Leu Ala Val Glu Ser Leu Leu Ile Ala Pro Tyr Ser Glu His Arg Thr

90 95 100aag tgg ctg cga aaa atc gct gag aaa ggc gtg gtc att ggc aat gcg 451Lys Trp Leu Arg Lys Ile Ala Glu Lys Gly Val Val Ile Gly Asn Ala

105 110 115ttg act gaa gtg gga aac aag cca ggt gag ctg aaa acc aag atc cga 499Leu Thr Glu Val Gly Asn Lys Pro Gly Glu Leu Lys Thr Lys Ile Arg

120 125 130aag gaa ggc gag tct tac gtt ctc agc gac acc aag ttc tat tcc acg 547Lys Glu Gly Glu Ser Tyr Val Leu Ser Asp Thr Lys Phe Tyr Ser Thr

135 140 145ggc agt ctt tac gcc gac tgg att caa gta cat gcg aaa gat gag gaa 595Gly Ser Leu Tyr Ala Asp Trp Ile Gln Val His Ala Lys Asp Glu Glu150 155 160 165gat caa gat gtt ttc gcc ttt gtt gat cgc gac gca tca ggc gtt gtt 643Asp Gln Asp Val Phe Ala Phe Val Asp Arg Asp Ala Ser Gly Val Val

170 175 180ttg gtg gat tac tgg gac gaa ttt ggg caa caa cta ttt gcc tcc gga 691Leu Val Asp Tyr Trp Asp Glu Phe Gly Gln Gln Leu Phe Ala Ser Gly

185 190 195acc agc ttc ttt gaa aaa gtc gtg gta gat cca ctg gac att gtc acc 739Thr Ser Phe Phe Glu Lys Val Val Val Asp Pro Leu Asp Ile Val Thr

200 205 210cgt gat tac acc gca ccc agc gct ttc cag gcg ctg gcg cag tca cat 787Arg Asp Tyr Thr Ala Pro Ser Ala Phe Gln Ala Leu Ala Gln Ser His

215 220 225cat ttg tct acg ttg act ggt att tcg cag gca atc acc cgt gac att 835His Leu Ser Thr Leu Thr Gly Ile Ser Gln Ala Ile Thr Arg Asp Ile230 235 240 245gtt acc tat gta caa aac cgc acc cgt att ttc agc cac gga agt ggt 883Val Thr Tyr Val Gln Asn Arg Thr Arg Ile Phe Ser His Gly Ser Gly

250 255 260gac ctt cca cgc ttt gat ccg cag gtg caa cag gtg gtg ggt gag gtg 931Asp Leu Pro Arg Phe Asp Pro Gln Val Gln Gln Val Val Gly Glu Val

265 270 275aaa gcc aag tcg tat gca gtc gag aaa atc ttt cag ggt ttc gca caa 979Lys Ala Lys Ser Tyr Ala Val Glu Lys Ile Phe Gln Gly Phe Ala Gln

280 285 290gaa ctg gat ctt gtc gtc gat aag gca aaa gcc ggc act gct acg gag 1027Glu Leu Asp Leu Val Val Asp Lys Ala Lys Ala Gly Thr Ala Thr Glu

295 300 305gtc gat ctg gcc gct gtc gac ctg agc gcc tac caa gcc cag tta gcg 1075Val Asp Leu Ala Ala Val Asp Leu Ser Ala Tyr Gln Ala Gln Leu Ala310 315 320 325gtg gca cct ttg gtg ctg agc cag gcc acc cag gcc ttt gag gtt ggc 1123Val Ala Pro Leu Val Leu Ser Gln Ala Thr Gln Ala Phe Glu Val Gly

330 335 340gca gat gcc tta aac ggc ggc cac gtg gct gcc caa tac acg atc gga 1171Ala Asp Ala Leu Asn Gly Gly His Val Ala Ala Gln Tyr Thr Ile Gly

345 350 355tcc ttg tca tgagccaaga aattttgagc cat 1203Ser Leu Ser

360<210>150<211>360<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>150Met Ile Ser Pro Gln Thr Ile Ile Asp Asn Leu Ala Pro Val Leu Ala 151015 Glu Ile Ala Ala Thr Ala Ala Gln Arg Glu Gln Asp Arg Glu Phe Ser

20 25 30Arg Asp Leu Ala Lys Gln Leu Ser Ala Gly Gly Phe Thr Lys Leu Arg

35 40 45Ile Pro Val Glu Phe Gly Gly Leu Gly Phe Ser Leu Pro Glu Ala Phe

50 55 60Glu Val Leu Val Ala Ala Ala Ala Ala Asp Ser Asn Ile Ala Gln Gly 65 70 75 80Leu Arg Pro His Phe Leu Ala Val Glu Ser Leu Leu Ile Ala Pro Tyr

85 90 95Ser Glu His Arg Thr Lys Trp Leu Arg Lys Ile Ala Glu Lys Gly Val

100 105 110Val Ile Gly Asn Ala Leu Thr Glu Val Gly Asn Lys Pro Gly Glu Leu

115 120 125Lys Thr Lys Ile Arg Lys Glu Gly Glu Ser Tyr Val Leu Ser Asp Thr

130 135 140Lys Phe Tyr Ser Thr Gly Ser Leu Tyr Ala Asp Trp Ile Gln Val His145 150 155 160Ala Lys Asp Glu Glu Asp Gln Asp Val Phe Ala Phe Val Asp Arg Asp

165 170 175Ala Ser Gly Val Val Leu Val Asp Tyr Trp Asp Glu Phe Gly Gln Gln

180 185 190Leu Phe Ala Ser Gly Thr Ser Phe Phe Glu Lys Val Val Val Asp Pro

195 200 205Leu Asp Ile Val Thr Arg Asp Tyr Thr Ala Pro Ser Ala Phe Gln Ala

210 215 220Leu Ala Gln Ser His His Leu Ser Thr Leu Thr Gly Ile Ser Gln Ala225 230 235 240Ile Thr Arg Asp Ile Val Thr Tyr Val Gln Asn Arg Thr Arg Ile Phe

245 250 255Ser His Gly Ser Gly Asp Leu Pro Arg Phe Asp Pro Gln Val Gln Gln

260 265 270Val Val Gly Glu Val Lys Ala Lys Ser Tyr Ala Val Glu Lys Ile Phe

275 280 285Gln Gly Phe Ala Gln Glu Leu Asp Leu Val Val Asp Lys Ala Lys Ala

290 295 300Gly Thr Ala Thr Glu Val Asp Leu Ala Ala Val Asp Leu Ser Ala Tyr305 310 315 320

Gln Ala Gln Leu Ala Val Ala Pro Leu Val Leu Ser Gln Ala Thr Gln

325 330 335Ala Phe Glu Val Gly Ala Asp Ala Leu Asn Gly Gly His Val Ala Ala

340 345 350Gln Tyr Thr Ile Gly Ser Leu Ser

355360<210>151<211>516<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (493)<223>RXN03065<400>151gacggcgcca actctgcatt cttcgcctca gcgtgcgtgg cagtgtttgc actgatcgtg 60ggcttctttg taaagaggcc agcccgctaa gctaggtcgc atg atc agc att gga 115

Met Ile Ser Ile Gly

1 5acc gac ctc gtt cac att tcg gcg ttc gca gag cag ctt gca cag ccg 163Thr Asp Leu Val His Ile Ser Ala Phe Ala Glu Gln Leu Ala Gln Pro

10 15 20gga agttcc ttc atg gag gtg ttt tcc gca ggg gag cgt cgt aaa gca 211Gly Ser Ser Phe Met Glu Val Phe Ser Ala Gly Glu Arg Arg Lys Ala

25 30 35aat gaa cgc cag gca agc cgc tac gcc gag cat ttg gcg ggg cgg tgg 259Asn Glu Arg Gln Ala Ser Arg Tyr Ala Glu His Leu Ala Gly Arg Trp

40 45 50gcg gca aaa gaa tcc ttt att aag gcc tgg tca cag gcc att tat ggc 307Ala Ala Lys Glu Ser Phe Ile Lys Ala Trp Ser Gln Ala Ile Tyr Gly

55 60 65cag cca ccc gtg atc gcc gaa gaa gcc gtg gtg tgg cgg gac atc gaa 355Gln Pro Pro Val Ile Ala Glu Glu Ala Val Val Trp Arg Asp Ile Glu 70 75 80 85gtt cgc gca gac gcg tgg ggg cgc gtc gcg atc gaa ttg gcg ccc gaa 403Val Arg Ala Asp Ala Trp Gly Arg Val Ala Ile Glu Leu Ala Pro Glu

90 95 100ttg gcc gca gtg gtc cgg gaa tcc atc ggg gag ttt tcc agc agc ttg 451Leu Ala Ala Val Val Arg Glu Ser Ile Gly Glu Phe Ser Ser Ser Leu

105 110 115agc atc agc cac gac ggc gac tac gcg gtg gaa cgt gcg tgt 493Ser Ile Ser His Asp Gly Asp Tyr Ala Val Glu Arg Ala Cys

120125130 tgactatcca gtagccacgg aga 516<210>152<211>131<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>152Met Ile Ser Ile Gly Thr Asp Leu Val His Ile Ser Ala Phe Ala Glu 151015 Gln Leu Ala Gln Pro Gly Ser Ser Phe Met Glu Val Phe Ser Ala Gly

20 25 30Glu Arg Arg Lys Ala Asn Glu Arg Gln Ala Ser Arg Tyr Ala Glu His

35 40 45Leu Ala Gly Arg Trp Ala Ala Lys Glu Ser Phe Ile Lys AlaTrp Ser

50 55 60Gln Ala Ile Tyr Gly Gln Pro Pro Val Ile Ala Glu Glu Ala Val Val 65 70 75 80Trp Arg Asp Ile Glu Val Arg Ala Asp Ala Trp Gly Arg Val Ala Ile

85 90 95Glu Leu Ala Pro Glu Leu Ala Ala Val Val Arg Glu Ser Ile Gly Glu

100 105 110Phe Ser Ser Ser Leu Ser Ile Ser His Asp Gly Asp Tyr Ala Val Glu

115 120 125Arg Ala Cys

130<210>153<211>543<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (520)<223>RXN03132<400>153taacttattt atacataaaa acacaataaa aaccgcacac gcggcgaaac ttcaataaat 60ccctagactg caaaaaatgg ttaggctaac cttatttcca atg aat gtg aat caa 115

Met Asn Val Asn Gln

1 5cag ttg gga gcc cgc acc gcc atg aac cac cct gag acc gca acc gtc 163Gln Leu Gly Ala Arg Thr Ala Met Asn His Pro Glu Thr Ala Thr Val

10 15 20ctt cgc tcc atc tct gac atg gtt agc acc gaa acc aat ccg cgc cgt 211Leu Arg Ser Ile Ser Asp Met Val Ser Thr Glu Thr Asn Pro Arg Arg

25 30 35aaa agc cgc ctc gag cag ctc att tac gcc acc gcc agc gcc tgg ccc 259Lys Ser Arg Leu Glu Gln Leu Ile Tyr Ala Thr Ala Ser Ala Trp Pro

40 45 50cac tac ccc att gcc cac gca gcc cag gcc gcg gtg caa tta gcc agg 307His Tyr Pro Ile Ala His Ala Ala Gln Ala Ala Val Gln Leu AlaArg

55 60 65cca atg cgg gtt ttt gag ctc cag agc ttt gaa ggc gtc aag cac gca 355Pro Met Arg Val Phe Glu Leu Gln Ser Phe Glu Gly Val Lys His Ala 70 75 80 85ctc cac cac atc gat ctt cgc ccc gcc ctc gaa tgg gac atc atg gga 403Leu His His Ile Asp Leu Arg Pro Ala Leu Glu Trp Asp Ile Met Gly

90 95 100ttt ccc gaa tcc ccc gac acg ctg ccc att ttg ctc agt gac ctg cgc 451Phe Pro Glu Ser Pro Asp Thr Leu Pro Ile Leu Leu Ser Asp Leu Arg

105 110 115gac ccc cct tac gcc acc act gct gtg cca cct caa tcc acg cca cgc 499Asp Pro Pro Tyr Ala Thr Thr Ala Val Pro Pro Gln Ser Thr Pro Arg

120 125 130tcc gct cac cga tcc aca cat tgacgcttcc aggcgccacc gcg 543Ser Ala His Arg Ser Thr His

135140<210>154<211>140<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>154Met Asn Val Asn Gln Gln Leu Gly Ala Arg Thr Ala Met Asn His Pro 151015 Glu Thr Ala Thr Val Leu Arg Ser Ile Ser Asp Met Val Ser Thr Glu

20 25 30Thr Asn Pro Arg Arg Lys Ser Arg Leu Glu Gln Leu Ile Tyr Ala Thr

35 40 45Ala Ser Ala Trp Pro His Tyr Pro Ile Ala His Ala Ala Gln Ala Ala

50 55 60Val Gln Leu Ala Arg Pro Met Arg Val Phe Glu Leu Gln Ser Phe Glu 65 70 75 80Gly Val Lys His Ala Leu His His Ile Asp Leu Arg Pro Ala Leu Glu

85 90 95Trp Asp Ile Met Gly Phe Pro Glu SerPro Asp Thr Leu Pro Ile Leu

100 105 110Leu Ser Asp Leu Arg Asp Pro Pro Tyr Ala Thr Thr Ala Val Pro Pro

115 120 125Gln Ser Thr Pro Arg Ser Ala His Arg Ser Thr His

130135140<210>155<211>461<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (438)<223>RXN03157<400>155ggc cac ctc gac atc gtg acc cgc gcc gcc gcg caa ttt agc gaa gtc 48Gly His Leu Asp Ile Val Thr Arg Ala Ala Ala Gln Phe Ser Glu Val 151015 acc atc ttg gtc acc gcc aac ccc aac aaa aac tca gga ctg ttc acc 96Thr Ile Leu Val Thr Ala Asn Pro Asn Lys Asn Ser Gly Leu Phe Thr

20 25 30gtc gca gaa cgc atg gat ctc atc cgc gaa tcc acc gca cac ctg gac 144Val Ala Glu Arg Met Asp Leu Ile Arg Glu Ser Thr Ala His Leu Asp

35 40 45aac gta aaa gta gac act tgg gcc tca ctg ctc gtg gat tac acc acc 192Asn Val Lys Val Asp Thr Trp Ala Ser Leu Leu Val Asp Tyr Thr Thr

50 55 60gaa cat ggc atc ggc gcc cta gtc aaa ggc ctg cga agc tcc ctc gac 240Glu His Gly Ile Gly Ala Leu Val Lys Gly Leu Arg Ser Ser Leu Asp 65 70 75 80tac gaa tac gag ctc ccc atg gca cag atg aac agg cga ctc acg ggc 288Tyr Glu Tyr Glu Leu Pro Met Ala Gln Met Asn Arg Arg Leu Thr Gly

85 90 95gta gac acc ttc ttc ctc ctc acc gac gag aaa tac ggc tac gtc agc 336Val Asp Thr Phe Phe Leu Leu Thr Asp Glu Lys Tyr Gly Tyr Val Ser

100 105 110tcc aca ctg tgc aaa gaa gtt gcc cgc ttc ggt ggc gat gtc tcc ggc 384Ser Thr Leu Cys Lys Glu Val Ala Arg Phe Gly Gly Asp Val Ser Gly

115 120 125ctc cta cct gag gta gtg gca aaa gcc gtg aca gaa aaa tac agc aac 432Leu Leu Pro Glu Val Val Ala Lys Ala Val Thr Glu Lys Tyr Ser Asn

130135140 cag cac tagtttcttt tgcatcaagc gtc 461Gln His145<210>156<211>146<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>156Gly His Leu Asp Ile Val Thr Arg Ala Ala Ala Gln Phe Ser Glu Val 151015 Thr Ile Leu Val Thr Ala Asn Pro Asn Lys Asn Ser Gly Leu Phe Thr

20 25 30Val Ala Glu Arg Met Asp Leu Ile Arg Glu Ser Thr Ala His Leu Asp

35 40 45Asn Val Lys Val Asp Thr Trp Ala Ser Leu Leu Val Asp Tyr Thr Thr

50 55 60Glu His Gly Ile Gly Ala Leu Val Lys Gly Leu Arg Ser Ser Leu Asp 65 70 75 80Tyr Glu Tyr Glu Leu Pro Met Ala Gln Met Asn Arg Arg Leu Thr Gly

85 90 95Val Asp Thr Phe Phe Leu Leu Thr Asp Glu Lys Tyr Gly Tyr Val Ser

100 105 110Ser Thr Leu Cys Lys Glu Val Ala Arg Phe Gly Gly Asp Val Ser Gly

115 120 125Leu Leu Pro Glu Val Val Ala Lys Ala Val Thr Glu Lys Tyr Ser Asn

130135140 Gln His145<210>157<211>1206<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1183)<223>RXN00934<400>157ccaacccctg tggtttggtg atttggatcc ggagcgtctc aagcgctcta gggagcagac 60aaatgttcac aaaccggtgg cattacagga ggacaattag gtg cga att gga atg 115

Val Arg Ile Gly Met

1 5gtc tgc ccg tac tcc ttc gat gag ccg ggc ggt gtt caa gcg cat atc 163Val Cys Pro Tyr Ser Phe Asp Glu Pro Gly Gly Val Gln Ala His Ile

10 15 20ctt gac tta gcg cga acc ttc att gcc caa ggc cat gag gtt cag gtg 211Leu Asp Leu Ala Arg Thr Phe Ile Ala Gln Gly His Glu Val Gln Val

25 30 35ctt ggt ccg tgt agt gcg gat acg cag gtg ccc gat ttc gtg gtg cgc 259Leu Gly Pro Cys Ser Ala Asp Thr Gln Val Pro Asp Phe Val Val Arg

40 45 50ggt ggt ggc agc atc ccg att ccg tac aat ggc tcg gtt gcc cgc ttg 307Gly Gly Gly Ser Ile Pro Ile Pro Tyr Asn Gly Ser Val Ala Arg Leu

55 60 65agc ttt ggg ccg aaa atg ttc aag gcc gtg cgc acg ttc ctc cgc gaa 355Ser Phe Gly Pro Lys Met Phe Lys Ala Val Arg Thr Phe Leu Arg Glu 70 75 80 85ggc aac ttc gat gtg ctg cat atc cat gaa ccg aat tca cca agt ttt 403Gly Asn Phe Asp Val Leu His Ile His Glu Pro Asn Ser Pro Ser Phe

90 95 100tcc atg gcg gcg cta cgc ttt gcg gaa ggc ccc atc gtt gct act tac 451Ser Met Ala Ala Leu Arg Phe Ala Glu Gly Pro Ile Val Ala Thr Tyr

105 110 115cac gcc tcc agt agc gga tcg aag ctg ctc aag gct ttc tta cca gtg 499His Ala Ser Ser Ser Gly Ser Lys Leu Leu Lys Ala Phe Leu Pro Val

120 125 130ctt tcg ccc atg ctg gag aaa gtg cgc gca ggc atc gcc gtg tct gaa 547Leu Ser Pro Met Leu Glu Lys Val Arg Ala Gly Ile Ala Val Ser Glu

135 140 145atg gct cgg cgc tgg cag gtg gag caa gtc ggc ggc gat ccc gtg ctg 595Met Ala Arg Arg Trp Gln Val Glu Gln Val Gly Gly Asp Pro Val Leu150 155 160 165atc ccc aac ggg gta gag acc tcc atg ttc aaa gcc gcg cgc caa atc 643Ile Pro Asn Gly Val Glu Thr Ser Met Phe Lys Ala Ala Arg Gln Ile

170 175 180gaa ccg aat gat cct gta gag atc gtc ttt ttg ggt cgc ctc gat gag 691Glu Pro Asn Asp Pro Val Glu Ile Val Phe Leu Gly Arg Leu Asp Glu

185 190 195tcc cgc aaa ggc ctc gac atc ctc ctg cgc gct ctg acc agg ctg gat 739Ser Arg Lys Gly Leu Asp Ile Leu Leu Arg Ala Leu Thr Arg Leu Asp

200 205 210cgc ccg ttt acc tgc acc gtc att ggc ggc ggc acc ccg cga gaa gtc 787Arg Pro Phe Thr Cys Thr Val Ile Gly Gly Gly Thr Pro Arg Glu Val

215 220 225gcc ggc atc aac ttt gtg ggc cgc gtc agc gat gag gaa aag gca gca 835Ala Gly Ile Asn Phe Val Gly Arg Val Ser Asp Glu Glu Lys Ala Ala230 235 240 245atc tta ggt cgc gca gac atc tat gtc gca ccc aac acc ggc ggc gaa 883Ile Leu Gly Arg Ala Asp Ile Tyr Val Ala Pro Asn Thr Gly Gly Glu

250 255 260agc ttc ggc atc gtg cta gtt gaa gcg atg gcc gcg gga tgc gct gtc 931Ser Phe Gly Ile Val Leu Val Glu Ala Met Ala Ala Gly Cys Ala Val

265 270 275gtc gcc agc gac cta gaa gcg ttc tcc ctg gtc acc gat tct gaa gcc 979Val Ala Ser Asp Leu Glu Ala Phe Ser Leu Val Thr Asp Ser Glu Ala

280 285 290gca cag cca gcgggc gtg cta ttt aaa acc ggc tca gac gcc gac cta 1027Ala Gln Pro Ala Gly Val Leu Phe Lys Thr Gly Ser Asp Ala Asp Leu

295 300 305gcc aaa aaa ctt caa gcg ctt atc gac gac ccc tcc tcc cgt tcc acg 1075Ala Lys Lys Leu Gln Ala Leu Ile Asp Asp Pro Ser Ser Arg Ser Thr310 315 320 325ctt atc gcc gcg ggg cta aag cgc gca aac gcc tac gac tgg tcg aca 1123Leu Ile Ala Ala Gly Leu Lys Arg Ala Asn Ala Tyr Asp Trp Ser Thr

330 335 340gta tcc acc cag gtc atg gca gtc tat gaa acc att gcg atc gac aaa 1171Val Ser Thr Gln Val Met Ala Val Tyr Glu Thr Ile Ala Ile Asp Lys

345 350 355gtg agg ctt gga tgacccttgt ttacctcctc atc 1206Val Arg Leu Gly

360<210>158<211>361<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>158Val Arg Ile Gly Met Val Cys Pro Tyr Ser Phe Asp Glu Pro Gly Gly 151015 Val Gln Ala His Ile Leu Asp Leu Ala Arg Thr Phe Ile Ala Gln Gly

20 25 30His Glu Val Gln Val Leu Gly Pro Cys Ser Ala Asp Thr Gln Val Pro

35 40 45Asp Phe Val Val Arg Gly Gly Gly Ser Ile Pro Ile Pro Tyr Asn Gly

50 55 60Ser Val Ala Arg Leu Ser Phe Gly Pro Lys Met Phe Lys Ala Val Arg 65 70 75 80Thr Phe Leu Arg Glu Gly Asn Phe Asp Val Leu His Ile His Glu Pro

85 90 95Asn Ser Pro Ser Phe Ser Met Ala Ala Leu Arg Phe Ala Glu Gly Pro

100 105110Ile Val Ala Thr Tyr His Ala Ser Ser Ser Gly Ser Lys Leu Leu Lys

115 120 125Ala Phe Leu Pro Val Leu Ser Pro Met Leu Glu Lys Val Arg Ala Gly

130 135 140Ile Ala Val Ser Glu Met Ala Arg Arg Trp Gln Val Glu Gln Val Gly145 150 155 160Gly Asp Pro Val Leu Ile Pro Asn Gly Val Glu Thr Ser Met Phe Lys

165 170 175Ala Ala Arg Gln Ile Glu Pro Asn Asp Pro Val Glu Ile Val Phe Leu

180 185 190Gly Arg Leu Asp Glu Ser Arg Lys Gly Leu Asp Ile Leu Leu Arg Ala

195 200 205Leu Thr Arg Leu Asp Arg Pro Phe Thr Cys Thr Val Ile Gly Gly Gly

210 215 220Thr Pro Arg Glu Val Ala Gly Ile Asn Phe Val Gly Arg Val Ser Asp225 230 235 240Glu Glu Lys Ala Ala Ile Leu Gly Arg Ala Asp Ile Tyr Val Ala Pro

245 250 255Asn Thr Gly Gly Glu Ser Phe Gly Ile Val Leu Val Glu Ala Met Ala

260 265 270Ala Gly Cys Ala Val Val Ala Ser Asp Leu Glu Ala Phe Ser Leu Val

275 280 285Thr Asp Ser Glu Ala Ala Gln Pro Ala Gly Val Leu Phe Lys Thr Gly

290 295 300Ser Asp Ala Asp Leu Ala Lys Lys Leu Gln Ala Leu Ile Asp Asp Pro305 310 315 320Ser Ser Arg Ser Thr Leu Ile Ala Ala Gly Leu Lys Arg Ala Asn Ala

325 330 335Tyr AspTrp Ser Thr Val Ser Thr Gln Val Met Ala Val Tyr Glu Thr

340 345 350Ile Ala Ile Asp Lys Val Arg Leu Gly

355360<210>159<211>1320<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1297)<223>RXN00792<400>159cacctttggt gctgagccag gccacccagg cctttgaggt tggcgcagat gccttaaacg 60gcggccacgt ggctgcccaa tacacgatcg gatccttgtc atg agc caa gaa att 115

Met Ser Gln Glu Ile

1 5ttg agc cat ttt gca ccc gca tta gag cgc att cga agc ggc gcc gtc 163Leu Ser His Phe Ala Pro Ala Leu Glu Arg Ile Arg Ser Gly Ala Val

10 15 20gag cgc gaa cag cag cgc gcc ttg cca gtg gaa gag att aaa gag ctg 211Glu Arg Glu Gln Gln Arg Ala Leu Pro Val Glu Glu Ile Lys Glu Leu

25 30 35gta gag cta ggt ttt act ggg ctt cga gtg ccc gaa gaa cta ggc ggt 259Val Glu Leu Gly Phe Thr Gly Leu Arg Val Pro Glu Glu Leu Gly Gly

40 45 50gcg ggc gct tcc ctg gaa agc gta gtt gag tta ctg atc gag atc gcg 307Ala Gly Ala Ser Leu Glu Ser Val Val Glu Leu Leu Ile Glu Ile Ala

55 60 65ggc gcc gat tcc aat atc gcc caa gcc ctg cgc gga cat ttt gcc ttc 355Gly Ala Asp Ser Asn Ile Ala Gln Ala Leu Arg Gly His Phe Ala Phe 70 75 80 85gtg gaa cta ctc ctg gaa gcg ccg gag agc gaa ttc cgc acc cat tgg 403Val Glu Leu Leu Leu Glu Ala Pro Glu Ser Glu Phe Arg Thr His Trp

90 95100ctg cgc gaa gtc gcc acc gga aga ctt gtg ggc aac gcc gaa agt gag 451Leu Arg Glu Val Ala Thr Gly Arg Leu Val Gly Asn Ala Glu Ser Glu

105 110 115aaa cgc ggc gtt tac ggc gat ccg cag acc ttc atc gat gag gtg gag 499Lys Arg Gly Val Tyr Gly Asp Pro Gln Thr Phe Ile Asp Glu Val Glu

120 125 130act gaa aac gga ccg att ttc gtg ctc aac ggc act aag ttt tat acc 547Thr Glu Asn Gly Pro Ile Phe Val Leu Asn Gly Thr Lys Phe Tyr Thr

135 140 145acc ggc acc tat ttt gcg gac tac acc tgg acc acc gcg ctg ctg cgc 595Thr Gly Thr Tyr Phe Ala Asp Tyr Thr Trp Thr Thr Ala Leu Leu Arg150 155 160 165aac ctt aac ggc caa gaa act ttg gtc agt ttg ccg gtc gat ctg cac 643Asn Leu Asn Gly Gln Glu Thr Leu Val Ser Leu Pro Val Asp Leu His

170 175 180gcg ccg ggc gtg gat gtt gct gat gat tgg agc ggg ttt ggg caa aag 691Ala Pro Gly Val Asp Val Ala Asp Asp Trp Ser Gly Phe Gly Gln Lys

185 190 195ctc acc gcc tct gga acg acc acg ttt aaa gac ctg gag gtg gat ccg 739Leu Thr Ala Ser Gly Thr Thr Thr Phe Lys Asp Leu Glu Val Asp Pro

200 205 210cgg tgg atc att cca cgc act gat gcg ccc acg ctg gtg tgg acg tat 787Arg Trp Ile Ile Pro Arg Thr Asp Ala Pro Thr Leu Val Trp Thr Tyr

215 220 225ctg cag ctg agc ctg ctg acc gtg ctg gtt ggc agt gcc gca gca gct 835Leu Gln Leu Ser Leu Leu Thr Val Leu Val Gly Ser Ala Ala Ala Ala230 235 240 245gtc gat gag gtg gtt gcc cgc gcc caa tcc tcc acc aga aat gcg tgg 883Val Asp Glu Val Val Ala Arg Ala Gln Ser Ser Thr Arg Asn Ala Trp

250 255 260aac cct ggc gtc gag cgc cgc agc gat ccg gcc gca acc ata gcg atc 931Asn Pro Gly Val Glu Arg Arg Ser Asp Pro Ala Ala Thr Ile Ala Ile

265 270 275ggc gac gca cgc agc cga gtc acc gtt att cgt gga gcg ctt ctc gac 979Gly Asp Ala Arg Ser Arg Val Thr Val Ile Arg Gly Ala Leu Leu Asp

280 285 290gcc acc cgc cac gtt tcc aac gcc gcc acg atc gta acc ccc gaa gcc 1027Ala Thr Arg His Val Ser Asn Ala Ala Thr Ile Val Thr Pro Glu Ala

295 300 305ttc aac gag gcg gac gct att gtt gca gcg ctc tgg ccc atc gtc tcc 1075Phe Asn Glu Ala Asp Ala Ile Val Ala Ala Leu Trp Pro Ile Val Ser310 315 320 325gga caa gct ttg gtg gtg aca tcc aac gtt ttc gat gcg gtg ggt gca 1123Gly Gln Ala Leu Val Val Thr Ser Asn Val Phe Asp Ala Val Gly Ala

330 335 340tct gca gtg ctt ggt gag cat tcc att gat cgc cac tgg cgc aat gtg 1171Ser Ala Val Leu Gly Glu His Ser Ile Asp Arg His Trp Arg Asn Val

345 350 355cgt acc gtg tcc tca aac aac ccg gtg ttc ctg gcc aag aat gca gtg 1219Arg Thr Val Ser Ser Asn Asn Pro Val Phe Leu Ala Lys Asn Ala Val

360 365 370ggg gag tat gcc ctc aac ggc act cct gtg ggt acc aac att ggt aaa 1267Gly Glu Tyr Ala Leu Asn Gly Thr Pro Val Gly Thr Asn Ile Gly Lys

375380385 gca ctg agc cgt ccg gtg agc cta agc agc tagacgtgtg atttcgctgg 1317Ala Leu Ser Arg Pro Val Ser Leu Ser Ser 390395 ttt1320<210>160<211>399<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>160Met Ser GlnGlu Ile Leu Ser His Phe Ala Pro Ala Leu Glu Arg Ile 151015 Arg Ser Gly Ala Val Glu Arg Glu Gln Gln Arg Ala Leu Pro Val Glu

20 25 30Glu Ile Lys Glu Leu Val Glu Leu Gly Phe Thr Gly Leu Arg Val Pro

35 40 45Glu Glu Leu Gly Gly Ala Gly Ala Ser Leu Glu Ser Val Val Glu Leu

50 55 60Leu Ile Glu Ile Ala Gly Ala Asp Ser Asn Ile Ala Gln Ala Leu Arg 65 70 75 80Gly His Phe Ala Phe Val Glu Leu Leu Leu Glu Ala Pro Glu Ser Glu

85 90 95Phe Arg Thr His Trp Leu Arg Glu Val Ala Thr Gly Arg Leu Val Gly

100 105 110Asn Ala Glu Ser Glu Lys Arg Gly Val Tyr Gly Asp Pro Gln Thr Phe

115 120 125Ile Asp Glu Val Glu Thr Glu Asn Gly Pro Ile Phe Val Leu Asn Gly

130 135 140Thr Lys Phe Tyr Thr Thr Gly Thr Tyr Phe Ala Asp Tyr Thr Trp Thr145 150 155 160Thr Ala Leu Leu Arg Asn Leu Asn Gly Gln Glu Thr Leu Val Ser Leu

165 170 175Pro Val Asp Leu His Ala Pro Gly Val Asp Val Ala Asp Asp Trp Ser

180 185 190Gly Phe Gly Gln Lys Leu Thr Ala Ser Gly Thr Thr Thr Phe Lys Asp

195 200 205Leu Glu Val Asp Pro Arg Trp Ile Ile Pro Arg Thr Asp Ala Pro Thr

210 215 220Leu Val Trp Thr Tyr Leu Gln Leu Ser Leu Leu Thr Val Leu Val Gly225230 235 240Ser Ala Ala Ala Ala Val Asp Glu Val Val Ala Arg Ala Gln Ser Ser

245 250 255Thr Arg Asn Ala Trp Asn Pro Gly Val Glu Arg Arg Ser Asp Pro Ala

260 265 270Ala Thr Ile Ala Ile Gly Asp Ala Arg Ser Arg Val Thr Val Ile Arg

275 280 285Gly Ala Leu Leu Asp Ala Thr Arg His Val Ser Asn Ala Ala Thr Ile

290 295 300Val Thr Pro Glu Ala Phe Asn Glu Ala Asp Ala Ile Val Ala Ala Leu305 310 315 320Trp Pro Ile Val Ser Gly Gln Ala Leu Val Val Thr Ser Asn Val Phe

325 330 335Asp Ala Val Gly Ala Ser Ala Val Leu Gly Glu His Ser Ile Asp Arg

340 345 350His Trp Arg Asn Val Arg Thr Val Ser Ser Asn Asn Pro Val Phe Leu

355 360 365Ala Lys Asn Ala Val Gly Glu Tyr Ala Leu Asn Gly Thr Pro Val Gly

370375380 Thr Asn Ile Gly Lys Ala Leu Ser Arg Pro Val Ser Leu Ser Ser 385390395<210>161<211>969<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101). (946)<223>RXN00931<400>161ccgtaaccta atcgttgaaa catcacctta ttgctgggct ttgcacgcta ctctttgtga 60gtaacctcac cgaagtgcat aaattaattg ggagtgatca gtg aaa act att gaa 115

Val Lys Thr Ile Glu

1 5gat att ttg acc ttg gaa gaa atc gac cgc gat att tac cgt ggt ccc 163Asp Ile Leu Thr Leu Glu Glu Ile Asp Arg Asp Ile Tyr Arg Gly Pro

10 15 20gtt atc gaa tct tat tta gcc agg act ttc ggt ggc cag gtc gct gcc 211Val Ile Glu Ser Tyr Leu Ala Arg Thr Phe Gly Gly Gln Val Ala Ala

25 30 35caa gct tta gta gca gca acg cat act gtt gat aaa gcc ttt act gtg 259Gln Ala Leu Val Ala Ala Thr His Thr Val Asp Lys Ala Phe Thr Val

40 45 50cat tct ttg cat ggc tac ttt ata gct cct ggt gat cca aca gca ccc 307His Ser Leu His Gly Tyr Phe Ile Ala Pro Gly Asp Pro Thr Ala Pro

55 60 65gca att tat tta gtg gat cga gtt cgc gac gga aaa agc tac gtc acc 355Ala Ile Tyr Leu Val Asp Arg Val Arg Asp Gly Lys Ser Tyr Val Thr 70 75 80 85cgc tcg gtg cgt ggc atc caa gac ggc gaa gta atc ttc agc atg cag 403Arg Ser Val Arg Gly Ile Gln Asp Gly Glu Val Ile Phe Ser Met Gln

90 95 100gcc agc ttt cat cgt ggg gat gaa ggc att gag cac atg gac aag atg 451Ala Ser Phe His Arg Gly Asp Glu Gly Ile Glu His Met Asp Lys Met

105 110 115cgt aaa gtt cca gct cct gat gag atc aag gga aca gta gaa cgt atg 499Arg Lys Val Pro Ala Pro Asp Glu Ile Lys Gly Thr Val Glu Arg Met

120 125 130ccg atc tca agt agg cga gtg ctt gat gaa tgg gcg gaa tgg gat atc 547Pro Ile Ser Ser Arg Arg Val Leu Asp Glu Trp Ala Glu Trp Asp Ile

135 140 145cgc gtt att ccg cag gat caa tta gaa ctc agc gat ttc acc gct act 595Arg Val Ile Pro Gln Asp Gln Leu Glu Leu Ser Asp Phe Thr Ala Thr150 155 160 165gag caa gct gtg tgg att cgg tgcacc gct gat ctt ccg gat aat ccc 643Glu Gln Ala Val Trp Ile Arg Cys Thr Ala Asp Leu Pro Asp Asn Pro

170 175 180acc ttc cac cag tgc tca ctg act tat ctg tcc gat atg act ttg ctg 691Thr Phe His Gln Cys Ser Leu Thr Tyr Leu Ser Asp Met Thr Leu Leu

185 190 195cat agt gcc ctg gtg cca cac cca ggt gag aaa atg cag atg gcc tca 739His Ser Ala Leu Val Pro His Pro Gly Glu Lys Met Gln Met Ala Ser

200 205 210ctt gat cac gct gtg tgg ttc ctg cgt ccc ttc cgc gtc gat gaa tgg 787Leu Asp His Ala Val Trp Phe Leu Arg Pro Phe Arg Val Asp Glu Trp

215 220 225ttg ctt tat gat cag cgc tct cca tcg gcc tca agt ggg cga gcc ttg 835Leu Leu Tyr Asp Gln Arg Ser Pro Ser Ala Ser Ser Gly Arg Ala Leu230 235 240 245act cac ggg cgg ctt ttc aac cag cag gga gat ttg gtc gct att gtc 883Thr His Gly Arg Leu Phe Asn Gln Gln Gly Asp Leu Val Ala Ile Val

250 255 260aat caa gag gga atg acc cgc aca ctc cac gag ggt gcg caa tca att 931Asn Gln Glu Gly Met Thr Arg Thr Leu His Glu Gly Ala Gln Ser Ile

265 270 275ccg atg cgc aaa gac taaaa tgcag cgaact tgaa gat 969Pro Met Arg Lys Asp

280<210>162<211>282<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>162Val Lys Thr Ile Glu Asp Ile Leu Thr Leu Glu Glu Ile Asp Arg Asp 151015 Ile Tyr Arg Gly Pro Val Ile Glu Ser Tyr Leu Ala Arg Thr Phe Gly

20 25 30Gly Gln Val Ala Ala Gln Ala Leu Val Ala Ala Thr His Thr Val Asp

35 40 45Lys Ala Phe Thr Val His Ser Leu His Gly Tyr Phe Ile Ala Pro Gly

50 55 60Asp Pro Thr Ala Pro Ala Ile Tyr Leu Val Asp Arg Val Arg Asp Gly 65 70 75 80Lys Ser Tyr Val Thr Arg Ser Val Arg Gly Ile Gln Asp Gly Glu Val

85 90 95Ile Phe Ser Met Gln Ala Ser Phe His Arg Gly Asp Glu Gly Ile Glu

100 105 110His Met Asp Lys Met Arg Lys Val Pro Ala Pro Asp Glu Ile Lys Gly

115 120 125Thr Val Glu Arg Met Pro Ile Ser Ser Arg Arg Val Leu Asp Glu Trp

130 135 140Ala Glu Trp Asp Ile Arg Val Ile Pro Gln Asp Gln Leu Glu Leu Ser145 150 155 160Asp Phe Thr Ala Thr Glu Gln Ala Val Trp Ile Arg Cys Thr Ala Asp

165 170 175Leu Pro Asp Asn Pro Thr Phe His Gln Cys Ser Leu Thr Tyr Leu Ser

180 185 190Asp Met Thr Leu Leu His Ser Ala Leu Val Pro His Pro Gly Glu Lys

195 200 205Met Gln Met Ala Ser Leu Asp His Ala Val Trp Phe Leu Arg Pro Phe

210 215 220Arg Val Asp Glu Trp Leu Leu Tyr Asp Gln Arg Ser Pro Ser Ala Ser225 230 235 240Ser Gly Arg Ala Leu Thr His Gly Arg Leu Phe Asn Gln Gln Gly Asp

245 250 255Leu Val Ala Ile Val Asn Gln Glu Gly Met Thr Arg Thr Leu His Glu

260 265 270Gly Ala Gln Ser Ile Pro Met Arg Lys Asp

275280<210>163<211>969<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<946><223>FRXA00931<400>163ccgtaaccta atcgttgaaa catcacctta ttgctgggct ttgcacgcta ctctttgtga 60gtaacctcac cgaagtgcat aaattaattg ggagtgatca gtg aaa act att gaa 115

Val Lys Thr Ile Glu

1 5gat att ttg acc ttg gaa gaa atc gac cgc gat att tac cgt ggt ccc 163Asp Ile Leu Thr Leu Glu Glu Ile Asp Arg Asp Ile Tyr Arg Gly Pro

10 15 20gtt atc gaa tct tat tta gcc agg act ttc ggt ggc cag gtc gct gcc 211Val Ile Glu Ser Tyr Leu Ala Arg Thr Phe Gly Gly Gln Val Ala Ala

25 30 35caa gct tta gta gca gca acg cat act gtt gat aaa gcc ttt act gtg 259Gln Ala Leu Val Ala Ala Thr His Thr Val Asp Lys Ala Phe Thr Val

40 45 50cat tct ttg cat ggc tac ttt ata gct cct ggt gat cca aca gca ccc 307His Ser Leu His Gly Tyr Phe Ile Ala Pro Gly Asp Pro Thr Ala Pro

55 60 65gca att tat tta gtg gat cga gtt cgc gac gga aaa agc tac gtc acc 355Ala Ile Tyr Leu Val Asp Arg Val Arg Asp Gly Lys Ser Tyr Val Thr 70 75 80 85cgc tcg gtg cgt ggc atc caa gac ggc gaa gta atc ttc agc atg cag 403Arg Ser Val Arg Gly Ile Gln Asp Gly Glu Val Ile Phe Ser Met Gln

90 95 100gcc agc ttt cat cgt ggg gat gaa ggc att gag cac atg gac aag atg 451Ala Ser Phe His Arg Gly Asp Glu Gly Ile Glu His Met Asp Lys Met

105 110 115cgt aaa gtt cca gct cct gat gag atc aag gga aca gta gaa cgt atg 499Arg Lys Val Pro Ala Pro Asp Glu Ile Lys Gly Thr Val Glu Arg Met

120 125 130ccg atc tca agt agg cga gtg ctt gat gaa tgg gcg gaa tgg gat atc 547Pro Ile Ser Ser Arg Arg Val Leu Asp Glu Trp Ala Glu Trp Asp Ile

135 140 145cgc gtt att ccg cag gat caa tta gaa ctc agc gat ttc acc gct act 595Arg Val Ile Pro Gln Asp Gln Leu Glu Leu Ser Asp Phe Thr Ala Thr150 155 160 165gag caa gct gtg tgg att cgg tgc acc gct gat ctt ccg gat aat ccc 643Glu Gln Ala Val Trp Ile Arg Cys Thr Ala Asp Leu Pro Asp Asn Pro

170 175 180acc ttc cac cag tgc tca ctg act tat ctg tcc gat atg act ttg ctg 691Thr Phe His Gln Cys Ser Leu Thr Tyr Leu Ser Asp Met Thr Leu Leu

185 190 195cat agt gcc ctg gtg cca cac cca ggt gag aaa atg cag atg gcc tca 739His Ser Ala Leu Val Pro His Pro Gly Glu Lys Met Gln Met Ala Ser

200 205 210ctt gat cac gct gtg tgg ttc ctg cgt ccc ttc cgc gtc gat gaa tgg 787Leu Asp His Ala Val Trp Phe Leu Arg Pro Phe Arg Val Asp Glu Trp

215 220 225ttg ctt tat gat cag cgc tct cca tcg gcc tca agt ggg cga gcc ttg 835Leu Leu Tyr Asp Gln Arg Ser Pro Ser Ala Ser Ser Gly Arg Ala Leu230 235 240 245act cac ggg cgg ctt ttc aac cag cag gga gat ttg gtc gct att gtc 883Thr His Gly Arg Leu Phe Asn Gln Gln Gly Asp Leu Val Ala Ile Val

250255 260aat caa gag gga atg acc cgc aca ctc cac gag ggt gcg caa tca att 931Asn Gln Glu Gly Met Thr Arg Thr Leu His Glu Gly Ala Gln Ser Ile

265 270 275ccg atg cgc aaa gac taaaatgcag cgaacttgaa gat 969Pro Met Arg Lys Asp

280<210>164<211>282<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>164Val Lys Thr Ile Glu Asp Ile Leu Thr Leu Glu Glu Ile Asp Arg Asp 151015 Ile Tyr Arg Gly Pro Val Ile Glu Ser Tyr Leu Ala Arg Thr Phe Gly

20 25 30Gly Gln Val Ala Ala Gln Ala Leu Val Ala Ala Thr His Thr Val Asp

35 40 45Lys Ala Phe Thr Val His Ser Leu His Gly Tyr Phe Ile Ala Pro Gly

50 55 60Asp Pro Thr Ala Pro Ala Ile Tyr Leu Val Asp Arg Val Arg Asp Gly 65 70 75 80Lys Ser Tyr Val Thr Arg Ser Val Arg Gly Ile Gln Asp Gly Glu Val

85 90 95Ile Phe Ser Met Gln Ala Ser Phe His Arg Gly Asp Glu Gly Ile Glu

100 105 110His Met Asp Lys Met Arg Lys Val Pro Ala Pro Asp Glu Ile Lys Gly

115 120 125Thr Val Glu Arg Met Pro Ile Ser Ser Arg Arg Val Leu Asp Glu Trp

130 135 140Ala Glu Trp Asp Ile Arg Val Ile Pro Gln Asp Gln Leu Glu Leu Ser145 150 155 160Asp Phe Thr Ala Thr Glu Gln Ala Val Trp Ile Arg Cys Thr Ala Asp

165 170 175Leu Pro Asp Asn Pro Thr Phe His Gln Cys Ser Leu Thr Tyr Leu Ser

180 185 190Asp Met Thr Leu Leu His Ser Ala Leu Val Pro His Pro Gly Glu Lys

195 200 205Met Gln Met Ala Ser Leu Asp His Ala Val Trp Phe Leu Arg Pro Phe

210 215 220Arg Val Asp Glu Trp Leu Leu Tyr Asp Gln Arg Ser Pro Ser Ala Ser225 230 235 240Ser Gly Arg Ala Leu Thr His Gly Arg Leu Phe Asn Gln Gln Gly Asp

245 250 255Leu Val Ala Ile Val Asn Gln Glu Gly Met Thr Arg Thr Leu His Glu

260 265 270Gly Ala Gln Ser Ile Pro Met Arg Lys Asp

275280<210>165<211>510<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). - (487)<223>RXN01421<400>165ttgatgcacg tgcagaaatc gtcggcggtc cgtggcaccc atctgttaag ggagactcgg 60ttactgcagg gatcctgcga gatcgagtaa acgcctaaag atg acg tcg aaa agc 115

Met Thr Ser Lys Ser

1 5att agc ggc aag cgc ccg aat ctg ccg tcg ctc act gga gcg cgg tgg 163Ile Ser Gly Lys Arg Pro Asn Leu Pro Ser Leu Thr Gly Ala Arg Trp

10 15 20ctc gcg gcg ctc gct gtt tat ttt ttg cat gcg ttg gtg ttt ttg tcg 211Leu Ala Ala Leu Ala Val Tyr Phe Leu His Ala Leu Val Phe Leu Ser

25 30 35gtg tat ccg ttc cag cag tcg gaa ctg ttt gcc aca atc cat aaa ttt 259Val Tyr Pro Phe Gln Gln Ser Glu Leu Phe Ala Thr Ile His Lys Phe

40 45 50gtc ccc atg cag ctg ggt tca gct ggt gta acc ttc ttc ttt atc ttg 307Val Pro Met Gln Leu Gly Ser Ala Gly Val Thr Phe Phe Phe Ile Leu

55 60 65tcc gga ttt ttg atc tat tgg tca aat agc cag ctc aag ggc atg aag 355Ser Gly Phe Leu Ile Tyr Trp Ser Asn Ser Gln Leu Lys Gly Met Lys 70 75 80 85aat gtg ctg tat tac tgc aag cgc cgc atc acc aag att tat ccc atg 403Asn Val Leu Tyr Tyr Cys Lys Arg Arg Ile Thr Lys Ile Tyr Pro Met

90 95 100cac ttg att gcg ttg ccg atg ttt att gag gcg tcg gcg aag ttc acg 451His Leu Ile Ala Leu Pro Met Phe Ile Glu Ala Ser Ala Lys Phe Thr

105 110 115act aca ggc att acc tgg gtg ctg att ttg cgc gag taaagctgtg 497Thr Thr Gly Ile Thr Trp Val Leu Ile Leu Arg Glu

120125 gctgcggaat gcg 510<510>166<211>129<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>166Met Thr Ser Lys Ser Ile Ser Gly Lys Arg Pro Asn Leu Pro Ser Leu 151015 Thr Gly Ala Arg Trp Leu Ala Ala Leu Ala Val Tyr Phe Leu His Ala

20 25 30Leu Val Phe Leu Ser Val Tyr Pro Phe Gln Gln Ser Glu Leu Phe Ala

35 40 45Thr Ile His Lys Phe Val Pro Met Gln Leu Gly Ser Ala Gly Val Thr

50 55 60Phe Phe Phe Ile Leu Ser Gly Phe Leu Ile Tyr Trp Ser Asn Ser Gln 65 70 75 80Leu Lys Gly Met Lys Asn Val Leu Tyr Tyr Cys Lys Arg Arg Ile Thr

85 9095Lys Ile Tyr Pro Met His Leu Ile Ala Leu Pro Met Phe Ile Glu Ala

100 105 110Ser Ala Lys Phe Thr Thr Thr Gly Ile Thr Trp Val Leu Ile Leu Arg

115120125 Glu<210>167<211>930<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (907)<223>RXN02342<400>167caggttcgtg ctgcgtgcgg gtagttttta aaggtaaaac tttttgggcg tgtcgccctt 60aaagcgcgct tttcgacgcg accccactac attggcttcc atg aac gtt gac att 115

Met Asn Val Asp Ile

1 5tca cga tcc aga gag ccg cta aac gtt gag ctc ctg aag gaa aaa ttg 163Ser Arg Ser Arg Glu Pro Leu Asn Val Glu Leu Leu Lys Glu Lys Leu

10 15 20ctc caa aac ggt gac ttt ggc cag gtc att tac gaa aaa gtg aca ggc 211Leu Gln Asn Gly Asp Phe Gly Gln Val Ile Tyr Glu Lys Val Thr Gly

25 30 35tcc act aat gct gac ttg ctg gca ctt gca ggt tct ggc gct cca aac 259Ser Thr Asn Ala Asp Leu Leu Ala Leu Ala Gly Ser Gly Ala Pro Asn

40 45 50tgg acg gtg aaa act gtc gag ttt caa gat cat gcg cgt ggg cga ctc 307Trp Thr Val Lys Thr Val Glu Phe Gln Asp His Ala Arg Gly Arg Leu

55 60 65ggc cgc ccg tgg tct gcc cct gag ggt tcc caa aca atc gtg tct gtg 355Gly Arg Pro Trp Ser Ala Pro Glu Gly Ser Gln Thr Ile Val Ser Val 70 75 80 85ctc gtt caa cta tct att gat caa gtg gac cgg att ggc act att cca 403Leu Val Gln Leu Ser Ile Asp Gln Val Asp Arg Ile Gly Thr Ile Pro

90 95 100ctc gcg gcg gga ctc gct gtc atg gat gcg ttg aat gac ctc ggt gtg 451Leu Ala Ala Gly Leu Ala Val Met Asp Ala Leu Asn Asp Leu Gly Val

105 110 115gaa ggt gcc gga ctg aaa tgg ccc aac gat gtt caa atc cac ggc aag 499Glu Gly Ala Gly Leu Lys Trp Pro Asn Asp Val Gln Ile His Gly Lys

120 125 130aaa ctc tgc ggc atc ctg gtg gaa gcc acc ggc ttt gat tcc acc cca 547Lys Leu Cys Gly Ile Leu Val Glu Ala Thr Gly Phe Asp Ser Thr Pro

135 140 145aca gtt gtc atc ggt tgg ggc act aat atc agc ctg act aaa gag gag 595Thr Val Val Ile Gly Trp Gly Thr Asn Ile Ser Leu Thr Lys Glu Glu150 155 160 165ctt cct gtt cct cat gca act tcc ctc gca ttg gaa ggt gtt gaa gtc 643Leu Pro Val Pro His Ala Thr Ser Leu Ala Leu Glu Gly Val Glu Val

170 175 180gac aga acc aca ttc ctt att aat atg ctc aca cat ctg cat act cga 691Asp Arg Thr Thr Phe Leu Ile Asn Met Leu Thr His Leu His Thr Arg

185 190 195ctg gac cag tgg cag ggt cca agt gtg gat tgg ctc gat gat tac cgt 739Leu Asp Gln Trp Gln Gly Pro Ser Val Asp Trp Leu Asp Asp Tyr Arg

200 205 210gcg gta tgt tcc agt att ggc caa gat gtt cga gtg ctt cta cct ggg 787Ala Val Cys Ser Ser Ile Gly Gln Asp Val Arg Val Leu Leu Pro Gly

215 220 225gat aaa gaa ctc tta ggt gaa gcg atc ggt gtc gcg act ggc gga gaa 835Asp Lys Glu Leu Leu Gly Glu Ala Ile Gly Val Ala Thr Gly Gly Glu230 235 240 245att cgt gtt cgc gat gct tcg ggc acc gtt cac acc ctc aac gcc ggt 883Ile Arg Val Arg Asp Ala Ser Gly Thr Val His Thr Leu Asn Ala Gly

250 255 260gaa att acg cac ctt cgc ctg cag taaggtgacg gtatggggaa ttc 930Glu Ile Thr His Leu Arg Leu Gln

265<210>168<211>269<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>168Met Asn Val Asp Ile Ser Arg Ser Arg Glu Pro Leu Asn Val Glu Leu 151015 Leu Lys Glu Lys Leu Leu Gln Asn Gly Asp Phe Gly Gln Val Ile Tyr

20 25 30Glu Lys Val Thr Gly Ser Thr Asn Ala Asp Leu Leu Ala Leu Ala Gly

35 40 45Ser Gly Ala Pro Asn Trp Thr Val Lys Thr Val Glu Phe Gln Asp His

50 55 60Ala Arg Gly Arg Leu Gly Arg Pro Trp Ser Ala Pro Glu Gly Ser Gln 65 70 75 80Thr Ile Val Ser Val Leu Val Gln Leu Ser Ile Asp Gln Val Asp Arg

85 90 95Ile Gly Thr Ile Pro Leu Ala Ala Gly Leu Ala Val Met Asp Ala Leu

100 105 110Asn Asp Leu Gly Val Glu Gly Ala Gly Leu Lys Trp Pro Asn Asp Val

115 120 125Gln Ile His Gly Lys Lys Leu Cys Gly Ile Leu Val Glu Ala Thr Gly

130 135 140Phe Asp Ser Thr Pro Thr Val Val Ile Gly Trp Gly Thr Asn Ile Ser145 150 155 160Leu Thr Lys Glu Glu Leu Pro Val Pro His Ala Thr Ser Leu Ala Leu

165 170 175Glu Gly Val Glu Val Asp Arg Thr Thr Phe Leu Ile Asn Met Leu Thr

180 185 190His Leu His Thr Arg Leu Asp Gln Trp Gln Gly Pro Ser Val Asp Trp

195 200 205Leu Asp Asp Tyr Arg Ala Val Cys Ser Ser Ile Gly Gln Asp Val Arg

210 215 220Val Leu Leu Pro Gly Asp Lys Glu Leu Leu Gly Glu Ala Ile Gly Val225 230 235 240Ala Thr Gly Gly Glu Ile Arg Val Arg Asp Ala Ser Gly Thr Val His

245 250 255Thr Leu Asn Ala Gly Glu Ile Thr His Leu Arg Leu Gln

260265<210>169<211>2762<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (2739)<223>RXN00563<400>169ttc tac aag gat ctc tac gca cgt tcc gca cgc ggc acg gca gca ctg 48Phe Tyr Lys Asp Leu Tyr Ala Arg Ser Ala Arg Gly Thr Ala Ala Leu 151015 tgg atc gtg gcg gct aac ttg agc tcc tac tca gac atc gac gcc atc 96Trp Ile Val Ala Ala Asn Leu Ser Ser Tyr Ser Asp Ile Asp Ala Ile

20 25 30atc aac tgg gtc gga tcc gag cag acc acc acc gtc aac ggc gca tcc 144Ile Asn Trp Val Gly Ser Glu Gln Thr Thr Thr Val Asn Gly Ala Ser

35 40 45aag ctg gtc aag cca gct ttg gtc cct acc ttg ctg ttc cca ttc gcg 192Lys Leu Val Lys Pro Ala Leu Val Pro Thr Leu Leu Phe Pro Phe Ala

50 55 60gca cct cgc gtg tcc gga tcc atg gca gat gca ggc cca cag gca gaa 240Ala Pro Arg Val Ser Gly Ser Met Ala Asp Ala Gly Pro Gln Ala Glu 65 70 75 80tcc cag atg cga ctt ctg ctc tgg tct gtt gag cgc ctc atc gca ggt 288Ser Gln Met Arg Leu Leu Leu Trp Ser Val Glu Arg Leu Ile Ala Gly

85 90 95ctt gcg cca ttg ggc tcc tcc atc aac gtg ggt cac cgc ctg cac gtg 336Leu Ala Pro Leu Gly Ser Ser Ile Asn Val Gly His Arg Leu His Val

100 105 110gtc atc cca ggt tca cca aac cgt gga cgc ttc ggt ggc gat ggt gca 384Val Ile Pro Gly Ser Pro Asn Arg Gly Arg Phe Gly Gly Asp Gly Ala

115 120 125tac ggt gaa tcc aag gca gct ctc gac gcc gtg gtt acc cgt tgg aac 432Tyr Gly Glu Ser Lys Ala Ala Leu Asp Ala Val Val Thr Arg Trp Asn

130 135 140gca gag caa gct gca tgg gga gca cac acc tcc ctc gtg cac gct cac 480Ala Glu Gln Ala Ala Trp Gly Ala His Thr Ser Leu Val His Ala His145 150 155 160atc ggt tgg gtt cgc ggc acc ggc ctc atg ggc ggc aac gat cct ttg 528Ile Gly Trp Val Arg Gly Thr Gly Leu Met Gly Gly Asn Asp Pro Leu

165 170 175gtc aag gca gct gaa gaa gca ggc gtg gaa acc tac tcc acc caa gaa 576Val Lys Ala Ala Glu Glu Ala Gly Val Glu Thr Tyr Ser Thr Gln Glu

180 185 190att gca gag aaa ctg ctg tcc cag gca act tcc act gtt cgc gag cag 624Ile Ala Glu Lys Leu Leu Ser Gln Ala Thr Ser Thr Val Arg Glu Gln

195 200 205gca gca tcc gcg cca atc acc gtc gac ttc act ggc gga ctt ggt gaa 672Ala Ala Ser Ala Pro Ile Thr Val Asp Phe Thr Gly Gly Leu Gly Glu

210 215 220tct gat ctg aac ctg gcg gaa atg gca cgt gca gaa gca gct aag gca 720Ser Asp Leu Asn Leu Ala Glu Met Ala Arg Ala Glu Ala Ala Lys Ala225 230 235 240gct aac gca cca gtg gtt gag gct cca cgc aca gtg gca gca ctg cca 768Ala Asn Ala Pro Val Val Glu Ala Pro Arg Thr Val Ala Ala Leu Pro

245 250 255act cct tac cga cca gtg gtt caa acc acc cct gat ttc gca ggt caa 816Thr Pro Tyr Arg Pro Val Val Gln Thr Thr Pro Asp Phe Ala Gly Gln

260 265 270gtc acc caa aac ctt gac gag atg gtc gtc atc gtt ggc gcc ggc gag 864Val Thr Gln Asn Leu Asp Glu Met Val Val Ile Val Gly Ala Gly Glu

275 280 285ctc ggc cca ctg ggt tct gca cgt acg cgt ttc gac gcc gaa ctc aac 912Leu Gly Pro Leu Gly Ser Ala Arg Thr Arg Phe Asp Ala Glu Leu Asn

290 295 300ggt tcc ctc tcc gcc gcg ggt gtc atc gaa ctt gca tgg acg atg gga 960Gly Ser Leu Ser Ala Ala Gly Val Ile Glu Leu Ala Trp Thr Met Gly305 310 315 320ctt atc cac tgg gat gaa gat cca aag cca ggc tgg tac gac gac tcc 1008Leu Ile His Trp Asp Glu Asp Pro Lys Pro Gly Trp Tyr Asp Asp Ser

325 330 335gac gac gca gtg gcc gaa gaa gac atc ttc gac cgc tac cac gac gaa 1056Asp Asp Ala Val Ala Glu Glu Asp Ile Phe Asp Arg Tyr His Asp Glu

340 345 350gtc atg gca cgc gtt ggt gtc cgc aag tac aat gac atg cct gag tac 1104Val Met Ala Arg Val Gly Val Arg Lys Tyr Asn Asp Met Pro Glu Tyr

355 360 365ggc atg atc gac aac ttt gca cca gag ctg acc acc gtc tac ctc gac 1152Gly Met Ile Asp Asn Phe Ala Pro Glu Leu Thr Thr Val Tyr Leu Asp

370 375 380cag gac ctc acc ttc aac gtg gga tcc cgc gaa gag gca ctg acc tac 1200Gln Asp Leu Thr Phe Asn Val Gly Ser Arg Glu Glu Ala Leu Thr Tyr385390 395 400gtc gac tcc gag cca gaa ctc acc ttt gct tct ttc gac gaa gca gca 1248Val Asp Ser Glu Pro Glu Leu Thr Phe Ala Ser Phe Asp Glu Ala Ala

405 410 415ggg gag tgg aag gtc act cgc aag gca ggc tcc gca atc cgc gta cct 1296Gly Glu Trp Lys Val Thr Arg Lys Ala Gly Ser Ala Ile Arg Val Pro

420 425 430cgc cgc atg gcg atg acc cgc ttc gtt ggt gga cag gtt cct aag gac 1344Arg Arg Met Ala Met Thr Arg Phe Val Gly Gly Gln Val Pro Lys Asp

435 440 445ttc gac cca gct gtg tgg ggc att cca gct gac atg gtg gac aac ctg 1392Phe Asp Pro Ala Val Trp Gly Ile Pro Ala Asp Met Val Asp Asn Leu

450 455 460gac acc gtc gcg ctg tgg aac att gtc tgt act gtc gac gcc ttc ctg 1440Asp Thr Val Ala Leu Trp Asn Ile Val Cys Thr Val Asp Ala Phe Leu465 470 475 480tcc gct gga ttc acc cca gca gag ctg ctt gct tcc gtt cac cca gca 1488Ser Ala Gly Phe Thr Pro Ala Glu Leu Leu Ala Ser Val His Pro Ala

485 490 495cgc gtg tcc tct acc caa ggc acc ggc atg ggc ggc atg gaa tcc ctc 1536Arg Val Ser Ser Thr Gln Gly Thr Gly Met Gly Gly Met Glu Ser Leu

500 505 510cgt ggc atc tac gtc gac cgc att ctg gca gag cca cgc gcc aac gac 1584Arg Gly Ile Tyr Val Asp Arg Ile Leu Ala Glu Pro Arg Ala Asn Asp

515 520 525gtt ctg cag gaa gca ctg ccc aac gtt gtt gca gct cac gtc atg cag 1632Val Leu Gln Glu Ala Leu Pro Asn Val Val Ala Ala His Val Met Gln

530 535 540tcc tac gtc ggt ggc tac gga cag atg atc cac cca gtc gca gct tgt 1680Ser Tyr Val Gly Gly Tyr Gly Gln Met Ile His Pro Val Ala Ala Cys545 550 555 560gca acc gca gct gtt tct gtg gaa gaa gca ctg gac aag atc cgc atc 1728Ala Thr Ala Ala Val Ser Val Glu Glu Ala Leu Asp Lys Ile Arg Ile

565 570 575ggc aag tcc gac ttc gtt gtc gca ggt ggc ttc gat gcc ctg tcc gtt 1776Gly Lys Ser Asp Phe Val Val Ala Gly Gly Phe Asp Ala Leu Ser Val

580 585 590gaa ggc atc acc ggc ttc ggc gac atg gca gca acc gcc gac tcc gca 1824Glu Gly Ile Thr Gly Phe Gly Asp Met Ala Ala Thr Ala Asp Ser Ala

595 600 605gag atg gaa ggc aag gga att gag cac cgc ttc ttc tcc cgc gcc aac 1872Glu Met Glu Gly Lys Gly Ile Glu His Arg Phe Phe Ser Arg Ala Asn

610 615 620gac cgg cgc cgc ggt gga ttc atc gaa tcc gaa ggt ggc gga acc gtc 1920Asp Arg Arg Arg Gly Gly Phe Ile Glu Ser Glu Gly Gly Gly Thr Val625 630 635 640ctt ctg gca cgc gga tca ctc gca gct gac ctg ggc ctt cca gta ctc 1968Leu Leu Ala Arg Gly Ser Leu Ala Ala Asp Leu Gly Leu Pro Val Leu

645 650 655ggt gtc atc gga ttc gca gag tcc ttt gca gat ggt gcc cac acc tcc 2016Gly Val Ile Gly Phe Ala Glu Ser Phe Ala Asp Gly Ala His Thr Ser

660 665 670atc cca gcc cca ggc ctc ggt gcc ctt ggt gct gct cgc gat ggt gtg 2064Ile Pro Ala Pro Gly Leu Gly Ala Leu Gly Ala Ala Arg Asp Gly Val

675 680 685gaa tct cgc ctt gca gta gca ctg cgt tcc gtc ggt gtc tct gct gat 2112Glu Ser Arg Leu Ala Val Ala Leu Arg Ser Val Gly Val Ser Ala Asp

690 695 700gag atc tcc att atc tcc aag cac gac acc tcc acc aac gcg aat gat 2160Glu Ile Ser Ile Ile Ser Lys His Asp Thr Ser Thr Asn Ala Asn Asp705 710 715 720cca aac gag tcc gac ctg cac gag cgc atc gca tcc gct atc ggt cgt 2208Pro Asn Glu Ser Asp Leu His Glu Arg Ile Ala Ser Ala Ile Gly Arg

725 730 735gca gac ggc aac ccg atg tac gtg att tcc cag aag tca ctc acc gga 2256Ala Asp Gly Asn Pro Met Tyr Val Ile Ser Gln Lys Ser Leu Thr Gly

740 745 750cac gcc aag ggt ggt gca gca gca ttc cag atg atc ggt ctc acc cag 2304His Ala Lys Gly Gly Ala Ala Ala Phe Gln Met Ile Gly Leu Thr Gln

755 760 765gtc ctc cga tcc gga ctg gtg cca gcc aac cgc gca ctc gac tgc gtt 2352Val Leu Arg Ser Gly Leu Val Pro Ala Asn Arg Ala Leu Asp Cys Val

770 775 780gac cca gta ctg tcc aag cat tcc cac ctc gtc tgg ctg cgc aag cca 2400Asp Pro Val Leu Ser Lys His Ser His Leu Val Trp Leu Arg Lys Pro785 790 795 800cta gac ctt cgt gcg aag gca cca aag gca ggt ctt gtt acc tcc ctt 2448Leu Asp Leu Arg Ala Lys Ala Pro Lys Ala Gly Leu Val Thr Ser Leu

805 810 815ggc ttc gga cac gtc tcc gct ctg gtt gcg att gtt cac cca gac gcc 2496Gly Phe Gly His Val Ser Ala Leu Val Ala Ile Val His Pro Asp Ala

820 825 830ttc tat gag gca gtt cgt gtg gca cgt ggt gct gag gca gct gac gta 2544Phe Tyr Glu Ala Val Arg Val Ala Arg Gly Ala Glu Ala Ala Asp Val

835 840 845tgg cgc gca tcc gcg atc gct cgc gaa gaagca ggc ctt cgt acc atc 2592Trp Arg Ala Ser Ala Ile Ala Arg Glu Glu Ala Gly Leu Arg Thr Ile

850 855 860gtc gcc ggt atg cac ggt ggc gta ctg tac gaa cgc cca gtc gag cgc 2640Val Ala Gly Met His Gly Gly Val Leu Tyr Glu Arg Pro Val Glu Arg865 870 875 880aac ctc ggt gtc cac gga gac gca gct aag gaa gtt gaa gct gca gtc 2688Asn Leu Gly Val His Gly Asp Ala Ala Lys Glu Val Glu Ala Ala Val

885 890 895ctc ctg gat tcc cgc gcc cgc cta gtt gac ggt gtc ctc cgc gcc gaa 2736Leu Leu Asp Ser Arg Ala Arg Leu Val Asp Gly Val Leu Arg Ala Glu

900905910 ggc tagttggtta ttgcgttgag ccc 2762Gly<210>170<211>913<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>170Phe Tyr Lys Asp Leu Tyr Ala Arg Ser Ala Arg Gly Thr Ala Ala Leu 151015 Trp Ile Val Ala Ala Asn Leu Ser Ser Tyr Ser Asp Ile Asp Ala Ile

20 25 30Ile Asn Trp Val Gly Ser Glu Gln Thr Thr Thr Val Asn Gly Ala Ser

35 40 45Lys Leu Val Lys Pro Ala Leu Val Pro Thr Leu Leu Phe Pro Phe Ala

50 55 60Ala Pro Arg Val Ser Gly Ser Met Ala Asp Ala Gly Pro Gln Ala Glu 65 70 75 80Ser Gln Met Arg Leu Leu Leu Trp Ser Val Glu Arg Leu Ile Ala Gly

85 90 95Leu Ala Pro Leu Gly Ser Ser Ile Asn Val Gly His Arg Leu His Val

100 105 110Val Ile Pro Gly Ser Pro Asn Arg Gly Arg Phe Gly Gly Asp Gly Ala

115 120125Tyr Gly Glu Ser Lys Ala Ala Leu Asp Ala Val Val Thr Arg Trp Asn

130 135 140Ala Glu Gln Ala Ala Trp Gly Ala His Thr Ser Leu Val His Ala His145 150 155 160Ile Gly Trp Val Arg Gly Thr Gly Leu Met Gly Gly Asn Asp Pro Leu

165 170 175Val Lys Ala Ala Glu Glu Ala Gly Val Glu Thr Tyr Ser Thr Gln Glu

180 185 190Ile Ala Glu Lys Leu Leu Ser Gln Ala Thr Ser Thr Val Arg Glu Gln

195 200 205Ala Ala Ser Ala Pro Ile Thr Val Asp Phe Thr Gly Gly Leu Gly Glu

210 215 220Ser Asp Leu Asn Leu Ala Glu Met Ala Arg Ala Glu Ala Ala Lys Ala225 230 235 240Ala Asn Ala Pro Val Val Glu Ala Pro Arg Thr Val Ala Ala Leu Pro

245 250 255Thr Pro Tyr Arg Pro Val Val Gln Thr Thr Pro Asp Phe Ala Gly Gln

260 265 270Val Thr Gln Asn Leu Asp Glu Met Val Val Ile Val Gly Ala Gly Glu

275 280 285Leu Gly Pro Leu Gly Ser Ala Arg Thr Arg Phe Asp Ala Glu Leu Asn

290 295 300Gly Ser Leu Ser Ala Ala Gly Val Ile Glu Leu Ala Trp Thr Met Gly305 310 315 320Leu Ile His Trp Asp Glu Asp Pro Lys Pro Gly Trp Tyr Asp Asp Ser

325 330 335Asp Asp Ala Val Ala Glu Glu Asp Ile Phe Asp Arg Tyr His Asp Glu

340 345 350Val Met Ala Arg Val Gly Val Arg Lys Tyr Asn Asp Met Pro Glu Tyr

355 360 365Gly Met Ile Asp Asn Phe Ala Pro Glu Leu Thr Thr Val Tyr Leu Asp

370 375 380Gln Asp Leu Thr Phe Asn Val Gly Ser Arg Glu Glu Ala Leu Thr Tyr385 390 395 400Val Asp Ser Glu Pro Glu Leu Thr Phe Ala Ser Phe Asp Glu Ala Ala

405 410 415 Gly Glu Trp Lys Val Thr Arg Lys Ala Gly Ser Ala Ile Arg Val Pro

420 425 430Arg Arg Met Ala Met Thr Arg Phe Val Gly Gly Gln Val Pro Lys Asp

435 440 445Phe Asp Pro Ala Val Trp Gly Ile Pro Ala Asp Met Val Asp Asn Leu

450 455 460Asp Thr Val Ala Leu Trp Asn Ile Val Cys Thr Val Asp Ala Phe Leu465 470 475 480Ser Ala Gly Phe Thr Pro Ala Glu Leu Leu Ala Ser Val His Pro Ala

485 490 495Arg Val Ser Ser Thr Gln Gly Thr Gly Met Gly Gly Met Glu Ser Leu

500 505 510Arg Gly Ile Tyr Val Asp Arg Ile Leu Ala Glu Pro Arg Ala Asn Asp

515 520 525Val Leu Gln Glu Ala Leu Pro Asn Val Val Ala Ala His Val Met Gln

530 535 540Ser Tyr Val Gly Gly Tyr Gly Gln Met Ile His Pro Val Ala Ala Cys545 550 555 560Ala Thr Ala Ala Val Ser Val Glu Glu Ala Leu Asp Lys Ile Arg Ile

565 570 575Gly Lys Ser Asp Phe Val Val Ala Gly GlyPhe Asp Ala Leu Ser Val

580 585 590Glu Gly Ile Thr Gly Phe Gly Asp Met Ala Ala Thr Ala Asp Ser Ala

595 600 605Glu Met Glu Gly Lys Gly Ile Glu His Arg Phe Phe Ser Arg Ala Asn

610 615 620Asp Arg Arg Arg Gly Gly Phe Ile Glu Ser Glu Gly Gly Gly Thr Val625 630 635 640Leu Leu Ala Arg Gly Ser Leu Ala Ala Asp Leu Gly Leu Pro Val Leu

645 650 655Gly Val Ile Gly Phe Ala Glu Ser Phe Ala Asp Gly Ala His Thr Ser

660 665 670Ile Pro Ala Pro Gly Leu Gly Ala Leu Gly Ala Ala Arg Asp Gly Val

675 680 685Glu Ser Arg Leu Ala Val Ala Leu Arg Ser Val Gly Val Ser Ala Asp

690 695 700Glu Ile Ser Ile Ile Ser Lys His Asp Thr Ser Thr Asn Ala Asn Asp705 710 715 720Pro Asn Glu Ser Asp Leu His Glu Arg Ile Ala Ser Ala Ile Gly Arg

725 730 735Ala Asp Gly Asn Pro Met Tyr Val Ile Ser Gln Lys Ser Leu Thr Gly

740 745 750His Ala Lys Gly Gly Ala Ala Ala Phe Gln Met Ile Gly Leu Thr Gln

755 760 765Val Leu Arg Ser Gly Leu Val Pro Ala Asn Arg Ala Leu Asp Cys Val

770 775 780Asp Pro Val Leu Ser Lys His Ser His Leu Val Trp Leu Arg Lys Pro785 790 795 800Leu Asp Leu Arg Ala Lys Ala Pro Lys Ala Gly Leu Val ThrSer Leu

805 810 815Gly Phe Gly His Val Ser Ala Leu Val Ala Ile Val His Pro Asp Ala

820 825 830Phe Tyr Glu Ala Val Arg Val Ala Arg Gly Ala Glu Ala Ala Asp Val

835 840 845Trp Arg Ala Ser Ala Ile Ala Arg Glu Glu Ala Gly Leu Arg Thr Ile

850 855 860Val Ala Gly Met His Gly Gly Val Leu Tyr Glu Arg Pro Val Glu Arg865 870 875 880Asn Leu Gly Val His Gly Asp Ala Ala Lys Glu Val Glu Ala Ala Val

885 890 895Leu Leu Asp Ser Arg Ala Arg Leu Val Asp Gly Val Leu Arg Ala Glu

900905910 Gly<210>171<211>2937<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (2914)<223>RXN02168<400>171agggtttagt catctatttc ggctacgctc acgtaaccta cgcattcgta agtggtcatg 60ggtccaagaa gcccattcca agacttagga gctttatttc gtg agt att tct tca 115

Val Ser Ile Ser Ser

1 5ctg aca ccg ctg cac tct ttc aaa gag cca gca att ctg tac gcc ggt 163Leu Thr Pro Leu His Ser Phe Lys Glu Pro Ala Ile Leu Tyr Ala Gly

10 15 20cag gct tct gcc tgg cag cag gtg atc gct gat tcc agc gaa gac cac 211Gln Ala Ser Ala Trp Gln Gln Val Ile Ala Asp Ser Ser Glu Asp His

25 30 35atc acc gca acg cac ctg cgc gag ctc ctg tct cgc tcc cgt gca aag 259Ile Thr Ala Thr His Leu Arg Glu Leu Leu Ser Arg Ser Arg Ala Lys

40 45 50act gca cct ttc gct cgc caa atc acc gcc atc gtg cct ggc tca ctt 307Thr Ala Pro Phe Ala Arg Gln Ile Thr Ala Ile Val Pro Gly Ser Leu

55 60 65gct cgt ctt gag gaa ctg acc cgc gaa gac gca caa atc ggt gca gac 355Ala Arg Leu Glu Glu Leu Thr Arg Glu Asp Ala Gln Ile Gly Ala Asp 70 75 80 85atc gac gca cag cct gcc gtt tcc att cca ggc att ctg ctg gga cag 403Ile Asp Ala Gln Pro Ala Val Ser Ile Pro Gly Ile Leu Leu Gly Gln

90 95 100atc gct gca acc cgt cag ctg cgt gac ctc gga ctc gat gtc gca gca 451Ile Ala Ala Thr Arg Gln Leu Arg Asp Leu Gly Leu Asp Val Ala Ala

105 110 115gct tcc cgc ctt gga cac tcc cag ggc att ttg ggc gtt gaa gca gta 499Ala Ser Arg Leu Gly His Ser Gln Gly Ile Leu Gly Val Glu Ala Val

120 125 130gac aat gaa gaa gac gtt tta gct ttc gcc atc ctg ctg ggc gca gca 547Asp Asn Glu Glu Asp Val Leu Ala Phe Ala Ile Leu Leu Gly Ala Ala

135 140 145gct tcc cag ttc gct ggc aag ggc gca cat atg ctc tct gtt cgc ggc 595Ala Ser Gln Phe Ala Gly Lys Gly Ala His Met Leu Ser Val Arg Gly150 155 160 165ctg tcc cgt gag atc atc cag gac acc atc gct ggt gtc gat ggg gta 643Leu Ser Arg Glu Ile Ile Gln Asp Thr Ile Ala Gly Val Asp Gly Val

170 175 180gag gtc tcc ctg cgc aac gct cgt gca cac ttt gtt gtc tct ggt aag 691Glu Val Ser Leu Arg Asn Ala Arg Ala His Phe Val Val Ser Gly Lys

185 190 195cca gag gca ctg aag aag gct gct gct gct cta cag cgc gca gct gat 739Pro Glu Ala Leu Lys Lys Ala Ala Ala Ala Leu Gln Arg Ala Ala Asp

200 205 210gtt tac aac gaa gac atc aac gaa aag cgc aag ggt gga tcc ctg gca 787Val Tyr Asn Glu Asp Ile Asn Glu Lys Arg Lys Gly Gly Ser Leu Ala

215 220 225gag cct aag ttt gac tac ttg gat gtg gcc att cct ttc cac cac tcc 835Glu Pro Lys Phe Asp Tyr Leu Asp Val Ala Ile Pro Phe His His Ser230 235 240 245tcc atg cag gac gca gcc gac ttg gct gtc gag tgg gca acc acc tgt 883Ser Met Gln Asp Ala Ala Asp Leu Ala Val Glu Trp Ala Thr Thr Cys

250 255 260ggc cta aac gtc aac gcg cgc gcg ttg gca gaa gca att cta gtt aac 931Gly Leu Asn Val Asn Ala Arg Ala Leu Ala Glu Ala Ile Leu Val Asn

265 270 275cca gct gac tgg gtt gag cag atc gca aac ctc aag gct gat tac gtt 979Pro Ala Asp Trp Val Glu Gln Ile Ala Asn Leu Lys Ala Asp Tyr Val

280 285 290ctt tcc ctc gat gca ggc gtc agc cgt ttc acc gct cca ttg cta gac 1027Leu Ser Leu Asp Ala Gly Val Ser Arg Phe Thr Ala Pro Leu Leu Asp

295 300 305ggt cgc gga atc tct ttg gtt cct gcg ttc tcc gct gca gag cgc gac 1075Gly Arg Gly Ile Ser Leu Val Pro Ala Phe Ser Ala Ala Glu Arg Asp310 315 320 325aac ttg gct cgc cct ggc ttc cac gtt cct acc gct gag gat tgg tcc 1123Asn Leu Ala Arg Pro Gly Phe His Val Pro Thr Ala Glu Asp Trp Ser

330 335 340gag ttc gct cca aag ctg gtt aag ctt cca aac ggt gag cac aag gtt 1171Glu Phe Ala Pro Lys Leu Val Lys Leu Pro Asn Gly Glu His Lys Val

345 350 355ctc acc ggg ttc tcc cgc ctg act ggt tat tcc cca atc gtc ctg gct 1219Leu Thr Gly Phe Ser Arg Leu Thr Gly Tyr Ser Pro Ile Val Leu Ala

360 365 370ggc atg acc cca acc acc gtt gat cct gag atc gtt gca gct gca gcg 1267Gly Met Thr Pro Thr Thr Val Asp Pro Glu Ile Val Ala Ala Ala Ala

375 380 385aac gct gga cac tgg gcc gaa atg gcc ggt ggc gga cag tac tct gaa 1315Asn Ala Gly His Trp Ala Glu Met Ala Gly Gly Gly Gln Tyr Ser Glu390 395 400 405gaa gtc ttc acc aag aac aag gaa aag ctc gtt tcc ctg ctc aag gtt 1363Glu Val Phe Thr Lys Asn Lys Glu Lys Leu Val Ser Leu Leu Lys Val

410 415 420gga cgc tcc gca cag ttc aac tcc atg ttc ttc gac cgc tac atg tgg 1411Gly Arg Ser Ala Gln Phe Asn Ser Met Phe Phe Asp Arg Tyr Met Trp

425 430 435aac ctg cag ttc ggt gca cag cgc atc gtt tcc aag gca cgt gca acc 1459Asn Leu Gln Phe Gly Ala Gln Arg lle Val Ser Lys Ala Arg Ala Thr

440 445 450ggt acc tcc atc aac ggt gtt gtt gtc tcc gct ggt atc cca gag gtt 1507Gly Thr Ser Ile Asn Gly Val Val Val Ser Ala Gly Ile Pro Glu Val

455 460 465gag gaa gca act gag ctg atc aac gat ctg aac gct gat ggc ttc cca 1555Glu Glu Ala Thr Glu Leu Ile Asn Asp Leu Asn Ala Asp Gly Phe Pro470 475 480 485tac gtt gca ttc aag cca ggc acc gtg gat cag atc cgc gca acc ctg 1603Tyr Val Ala Phe Lys Pro Gly Thr Val Asp Gln Ile Arg Ala Thr Leu

490 495 500aag att gct gat gca aac cca gag acc aag atc atc atc cag atc gag 1651Lys Ile Ala Asp Ala Asn Pro Glu Thr Lys Ile Ile Ile Gln Ile Glu

505 510 515gac gga cac gct ggt ggc cac cac tcc tgg gtc aac ttg gac gat ctg 1699Asp Gly His Ala Gly Gly His His Ser Trp Val Asn Leu Asp Asp Leu

520 525 530ctc ctg acc acc tac gca gag ctg cgt tcc cgc aag aac gtt gtc gtc 1747Leu Leu Thr Thr Tyr Ala Glu Leu Arg Ser Arg Lys Asn Val Val Val

535 540 545atg atc ggt ggc ggc atc gga acc cct gca aag gct gct tac tac ctg 1795Met Ile Gly Gly Gly Ile Gly Thr Pro Ala Lys Ala Ala Tyr Tyr Leu550 555 560 565acc ggt gaa tgg tcc acc gat ttg ggc ttc cca gca atg cca gtg gac 1843Thr Gly Glu Trp Ser Thr Asp Leu Gly Phe Pro Ala Met Pro Val Asp

570 575 580ggc atc ctc gtg ggt acc gct gcc atg gca acc aag gaa gca acc act 1891Gly Ile Leu Val Gly Thr Ala Ala Met Ala Thr Lys Glu Ala Thr Thr

585 590 595tct cct cag gtc aag cag gca ctg gtc gac acc cca ggt gtt gat cca 1939Ser Pro Gln Val Lys Gln Ala Leu Val Asp Thr Pro Gly Val Asp Pro

600 605 610cac gac gct ggc ggc tgg gtt ggc cgt ggc gat gct cgt ggt ggc gtg 1987His Asp Ala Gly Gly Trp Val Gly Arg Gly Asp Ala Arg Gly Gly Val

615 620 625acc tct ggt ctg tca cac ctg cac gct gac atg tac gag ctg gac aac 2035Thr Ser Gly Leu Ser His Leu His Ala Asp Met Tyr Glu Leu Asp Asn630 635 640 645gat tct gct gca gct tcc cgc ctg atc tct tcc atc gat tct gat gat 2083Asp Ser Ala Ala Ala Ser Arg Leu Ile Ser Ser Ile Asp Ser Asp Asp

650 655 660tac gca gat cac cgc gaa gag ctc atc gag gct atc aac aag acc gct 2131Tyr Ala Asp His Arg Glu Glu Leu Ile Glu Ala Ile Asn Lys Thr Ala

665 670 675aag cct ttc ttc ggc gag gtc gaa gag atg act tac gca gag tgg atc 2179Lys Pro Phe Phe Gly Glu Val Glu Glu Met Thr Tyr Ala Glu Trp Ile

680 685 690cag cgt tgg gtt gag ctt gct tac cca act cag gac cca acc tgg gat 2227Gln Arg Trp Val Glu Leu Ala Tyr Pro Thr Gln Asp Pro Thr Trp Asp

695 700 705gat cgt ttc ctc gat ttg gtt cac cgc att gaa gct cgt ctc aac gag 2275Asp Arg Phe Leu Asp Leu Val His Arg Ile Glu Ala Arg Leu Asn Glu710 715 720 725gca gag cac ggc gcc atc acc aca ctg ttc cca gac cat gcg tct gtg 2323Ala Glu His Gly Ala Ile Thr Thr Leu Phe Pro Asp His Ala Ser Val

730 735 740gaa aat gag gaa gag gcc gtc gaa aag ctt ctt gct gct tac ccg cag 2371Glu Asn Glu Glu Glu Ala Val Glu Lys Leu Leu Ala Ala Tyr Pro Gln

745 750 755gcc cgc gag atc cag gtc tct gcg cgc gac gcc gcg tgg ttt att ggt 2419Ala Arg Glu Ile Gln Val Ser Ala Arg Asp Ala Ala Trp Phe Ile Gly

760 765 770ctg tgc cgc aag cac cac aag cct atg cct tgg gtt cca gca atc gat 2467Leu Cys Arg Lys His His Lys Pro Met Pro Trp Val Pro Ala Ile Asp

775 780 785gct gac cta gca cgc tgg tgg ggc ctt gac acc ctg tgg cag tcc cag 2515Ala Asp Leu Ala Arg Trp Trp Gly Leu Asp Thr Leu Trp Gln Ser Gln790 795 800 805aac gag cgc tac ggc gcg aac tca gtc cgc gtt atc cca gga ccagtc 2563Asn Glu Arg Tyr Gly Ala Asn Ser Val Arg Val Ile Pro Gly Pro Val

810 815 820tcc gtc gcc ggc atc gac cgt gtt gac gag cca gtt gca gag ctg ctc 2611Ser Val Ala Gly Ile Asp Arg Val Asp Glu Pro Val Ala Glu Leu Leu

825 830 835ggc cgc ttc gaa gct gcc tgc gtt gac gct ctc gac ggc gag cca gaa 2659Gly Arg Phe Glu Ala Ala Cys Val Asp Ala Leu Asp Gly Glu Pro Glu

840 845 850gag atc ttc gct cgc ctc aat gag tcc aag aac gag cgc gaa ttc ctg 2707Glu Ile Phe Ala Arg Leu Asn Glu Ser Lys Asn Glu Arg Glu Phe Leu

855 860 865ctg gct acc cca cac atc gtg tgg cac ggc aac ctg atc gac aac cca 2755Leu Ala Thr Pro His Ile Val Trp His Gly Asn Leu Ile Asp Asn Pro870 875 880 885gct cac gtc ctc aac gag ggt gct ttc gag ctc atc gag gag gat ggc 2803Ala His Val Leu Asn Glu Gly Ala Phe Glu Leu Ile Glu Glu Asp Gly

890 895 900tac tgg gtc atc cgt atc ctg gct gat tcc tac ttc gac gat ctg cca 2851Tyr Trp Val Ile Arg Ile Leu Ala Asp Ser Tyr Phe Asp Asp Leu Pro

905 910 915gtt gag cag cgc cca tac ctg gtt cag cat gtt gac atc cca gtt gag 2899Val Glu Gln Arg Pro Tyr Leu Val Gln His Val Asp Ile Pro Val Glu

920 925 930ctg ggt gac gct ggt tgaaccggtg gtttcccaat tgg 2937Leu Gly Asp Ala Gly

935<210>172<211>938<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>172Val Ser Ile Ser Ser Leu Thr Pro Leu His Ser Phe Lys Glu Pro Ala 151015 Ile Leu Tyr Ala Gly Gln Ala Ser Ala Trp Gln Gln Val Ile Ala Asp

20 25 30Ser Ser Glu Asp His Ile Thr Ala Thr His Leu Arg Glu Leu Leu Ser

35 40 45Arg Ser Arg Ala Lys Thr Ala Pro Phe Ala Arg Gln Ile Thr Ala Ile

50 55 60Val Pro Gly Ser Leu Ala Arg Leu Glu Glu Leu Thr Arg Glu Asp Ala 65 70 75 80Gln Ile Gly Ala Asp Ile Asp Ala Gln Pro Ala Val Ser Ile Pro Gly

85 90 95Ile Leu Leu Gly Gln Ile Ala Ala Thr Arg Gln Leu Arg Asp Leu Gly

100 105 110Leu Asp Val Ala Ala Ala Ser Arg Leu Gly His Ser Gln Gly Ile Leu

115 120 125Gly Val Glu Ala Val Asp Asn Glu Glu Asp Val Leu Ala Phe Ala Ile

130 135 140Leu Leu Gly Ala Ala Ala Ser Gln Phe Ala Gly Lys Gly Ala His Met145 150 155 160Leu Ser Val Arg Gly Leu Ser Arg Glu Ile Ile Gln Asp Thr Ile Ala

165 170 175Gly Val Asp Gly Val Glu Val Ser Leu Arg Asn Ala Arg Ala His Phe

180 185 190Val Val Ser Gly Lys Pro Glu Ala Leu Lys Lys Ala Ala Ala Ala Leu

195 200 205Gln Arg Ala Ala Asp Val Tyr Asn Glu Asp Ile Asn Glu Lys Arg Lys

210 215 220Gly Gly Ser Leu Ala Glu Pro Lys Phe Asp Tyr Leu Asp Val Ala Ile225 230 235 240Pro Phe His His Ser Ser Met Gln Asp Ala Ala Asp Leu AlaVal Glu

245 250 255Trp Ala Thr Thr Cys Gly Leu Asn Val Asn Ala Arg Ala Leu Ala Glu

260 265 270Ala Ile Leu Val Asn Pro Ala Asp Trp Val Glu Gln Ile Ala Asn Leu

275 280 285Lys Ala Asp Tyr Val Leu Ser Leu Asp Ala Gly Val Ser Arg Phe Thr

290 295 300Ala Pro Leu Leu Asp Gly Arg Gly Ile Ser Leu Val Pro Ala Phe Ser305 310 315 320Ala Ala Glu Arg Asp Asn Leu Ala Arg Pro Gly Phe His Val Pro Thr

325 330 335Ala Glu Asp Trp Ser Glu Phe Ala Pro Lys Leu Val Lys Leu Pro Asn

340 345 350Gly Glu His Lys Val Leu Thr Gly Phe Ser Arg Leu Thr Gly Tyr Ser

355 360 365Pro Ile Val Leu Ala Gly Met Thr Pro Thr Thr Val Asp Pro Glu Ile

370 375 380Val Ala Ala Ala Ala Asn Ala Gly His Trp Ala Glu Met Ala Gly Gly385 390 395 400Gly Gln Tyr Ser Glu Glu Val Phe Thr Lys Asn Lys Glu Lys Leu Val

405 410 415Ser Leu Leu Lys Val Gly Arg Ser Ala Gln Phe Asn Ser Met Phe Phe

420 425 430Asp Arg Tyr Met Trp Asn Leu Gln Phe Gly Ala Gln Arg Ile Val Ser

435 440 445Lys Ala Arg Ala Thr Gly Thr Ser Ile Asn Gly Val Val Val Ser Ala

450 455 460Gly Ile Pro Glu Val Glu Glu Ala Thr Glu Leu Ile Asn Asp Leu Asn465470 475 480Ala Asp Gly Phe Pro Tyr Val Ala Phe Lys Pro Gly Thr Val Asp Gln

485 490 495Ile Arg Ala Thr Leu Lys Ile Ala Asp Ala Asn Pro Glu Thr Lys Ile

500 505 510Ile Ile Gln Ile Glu Asp Gly His Ala Gly Gly His His Ser Trp Val

515 520 525Asn Leu Asp Asp Leu Leu Leu Thr Thr Tyr Ala Glu Leu Arg Ser Arg

530 535 540Lys Asn Val Val Val Met Ile Gly Gly Gly Ile Gly Thr Pro Ala Lys545 550 555 560Ala Ala Tyr Tyr Leu Thr Gly Glu Trp Ser Thr Asp Leu Gly Phe Pro

565 570 575Ala Met Pro Val Asp Gly Ile Leu Val Gly Thr Ala Ala Met Ala Thr

580 585 590Lys Glu Ala Thr Thr Ser Pro Gln Val Lys Gln Ala Leu Val Asp Thr

595 600 605Pro Gly Val Asp Pro His Asp Ala Gly Gly Trp Val Gly Arg Gly Asp

610 615 620Ala Arg Gly Gly Val Thr Ser Gly Leu Ser His Leu His Ala Asp Met625 630 635 640Tyr Glu Leu Asp Asn Asp Ser Ala Ala Ala Ser Arg Leu Ile Ser Ser

645 650 655Ile Asp Ser Asp Asp Tyr Ala Asp His Arg Glu Glu Leu Ile Glu Ala

660 665 670Ile Asn Lys Thr Ala Lys Pro Phe Phe Gly Glu Val Glu Glu Met Thr

675 680 685Tyr Ala Glu Trp Ile Gln Arg Trp Val Glu Leu Ala Tyr Pro Thr Gln

690 695 700Asp Pro Thr Trp Asp Asp Arg Phe Leu Asp Leu Val His Arg Ile Glu705 710 715 720Ala Arg Leu Asn Glu Ala Glu His Gly Ala Ile Thr Thr Leu Phe Pro

725 730 735Asp His Ala Ser Val Glu Asn Glu Glu Glu Ala Val Glu Lys Leu Leu

740 745 750Ala Ala Tyr Pro Gln Ala Arg Glu Ile Gln Val Ser Ala Arg Asp Ala

755 760 765Ala Trp Phe Ile Gly Leu Cys Arg Lys His His Lys Pro Met Pro Trp

770 775 780Val Pro Ala Ile Asp Ala Asp Leu Ala Arg Trp Trp Gly Leu Asp Thr785 790 795 800Leu Trp Gln Ser Gln Asn Glu Arg Tyr Gly Ala Asn Ser Val Arg Val

805 810 815Ile Pro Gly Pro Val Ser Val Ala Gly Ile Asp Arg Val Asp Glu Pro

820 825 830Val Ala Glu Leu Leu Gly Arg Phe Glu Ala Ala Cys Val Asp Ala Leu

835 840 845Asp Gly Glu Pro Glu Glu Ile Phe Ala Arg Leu Asn Glu Ser Lys Asn

850 855 860Glu Arg Glu Phe Leu Leu Ala Thr Pro His Ile Val Trp His Gly Asn865 870 875 880Leu Ile Asp Asn Pro Ala His Val Leu Asn Glu Gly Ala Phe Glu Leu

885 890 895Ile Glu Glu Asp Gly Tyr Trp Val Ile Arg Ile Leu Ala Asp Ser Tyr

900 905 910Phe Asp Asp Leu Pro Val Glu Gln Arg Pro Tyr Leu Val Gln His Val

915 920 925Asp Ile Pro Val Glu Leu Gly Asp Ala Gly

930935<210>173<211>921<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (898)<223>RXN01090<400>173gccggtttgg gctggttgga gctctagatc gtaagtggtg tcgtacccat gacgtaccat 60taaccacgaa cgttttaaag aagccacgaa ggagcctgac atg gcg tta cca cta 115

Met Ala Leu Pro Leu

1 5ccc agc aag agc gct cga gca ctt gtt act ggg gca agc caa ggc att 163Pro Ser Lys Ser Ala Arg Ala Leu Val Thr Gly Ala Ser Gln Gly Ile

10 15 20ggc ctc gcc atc gcc aaa gat ttg gcg cgg tat ggg cac aac ctc att 211Gly Leu Ala Ile Ala Lys Asp Leu Ala Arg Tyr Gly His Asn Leu Ile

25 30 35ttg gtt gct cgc cgc gag gat gtc ctc aaa gag atc gcc gca gat cta 259Leu Val Ala Arg Arg Glu Asp Val Leu Lys Glu Ile Ala Ala Asp Leu

40 45 50gag aag aag cac ggc gtg atc gtt gag gtc cgc ccg gtg gat ttg agt 307Glu Lys Lys His Gly Val Ile Val Glu Val Arg Pro Val Asp Leu Ser

55 60 65gat gag cca gcc cgc aag gtg ttg atc gat gag atc aag aca agg gaa 355Asp Glu Pro Ala Arg Lys Val Leu Ile Asp Glu Ile Lys Thr Arg Glu 70 75 80 85atc aac atc atc att aac tct gct ggc atc gca agc ttt ggg ccg ttc 403Ile Asn Ile Ile Ile Asn Ser Ala Gly Ile Ala Ser Phe Gly Pro Phe

90 95 100aag gac cag gat tgg tct tat gag act gcc cag ttc tca ctt aat gcc 451Lys Asp Gln Asp Trp Ser Tyr Glu Thr Ala Gln Phe Ser Leu Asn Ala

105 110 115aca gcc gtt ttt gag ctc acc cac gcg gtg ttg ggt ggc atg att gac 499Thr Ala Val Phe Glu Leu Thr His Ala Val Leu Gly Gly Met Ile Asp

120 125 130cgt ggc acg ggc gct att tgc aat gtg gga tct gcg gct ggc aat gtg 547Arg Gly Thr Gly Ala Ile Cys Asn Val Gly Ser Ala Ala Gly Asn Val

135 140 145cca atc ccc aac aac gcc acg tat gtg ctc acc aag gct ggc gtg aac 595Pro Ile Pro Asn Asn Ala Thr Tyr Val Leu Thr Lys Ala Gly Val Asn150 155 160 165gcg ttc acc gag gca atg cat tat gag ctg cgc gga act ggt gtg gcg 643Ala Phe Thr Glu Ala Met His Tyr Glu Leu Arg Gly Thr Gly Val Ala

170 175 180tgt act ttg ctc gca ccg gga cct gtc cgt gag gcg gag atc cct gag 691Cys Thr Leu Leu Ala Pro Gly Pro Val Arg Glu Ala Glu Ile Pro Glu

185 190 195tct gag aag tcg atc gtg gac aag gtt gtc cct gat ttc ttg tgg acc 739Ser Glu Lys Ser Ile Val Asp Lys Val Val Pro Asp Phe Leu Trp Thr

200 205 210acc tat gag tcc tgc tcc gca gag acc ttg cgt gcg ctg tct aag aat 787Thr Tyr Glu Ser Cys Ser Ala Glu Thr Leu Arg Ala Leu Ser Lys Asn

215 220 225cag cgt cgc gtt gtt cca ggt ccg ctg tcc aag gcc atg aat ttt gtg 835Gln Arg Arg Val Val Pro Gly Pro Leu Ser Lys Ala Met Asn Phe Val230 235 240 245tcc tct gtt gct cca acc gct gtg ctc tcc cct gtt atg ggc tgg gtt 883Ser Ser Val Ala Pro Thr Ala Val Leu Ser Pro Val Met Gly Trp Val

250 255 260tat aag aag atg ggt tagtttttaa aagtgtctga atc 921Tyr Lys Lys Met Gly

265<210>174<211>266<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>174Met Ala Leu Pro Leu Pro Ser Lys Ser Ala Arg Ala Leu Val Thr Gly 151015 Ala Ser Gln Gly Ile Gly Leu Ala Ile Ala Lys Asp Leu Ala Arg Tyr

20 25 30Gly His Asn Leu Ile Leu Val Ala Arg Arg Glu Asp Val Leu Lys Glu

35 40 45Ile Ala Ala Asp Leu Glu Lys Lys His Gly Val Ile Val Glu Val Arg

50 55 60Pro Val Asp Leu Ser Asp Glu Pro Ala Arg Lys Val Leu Ile Asp Glu 65 70 75 80Ile Lys Thr Arg Glu Ile Asn Ile Ile Ile Asn Ser Ala Gly Ile Ala

85 90 95Ser Phe Gly Pro Phe Lys Asp Gln Asp Trp Ser Tyr Glu Thr Ala Gln

100 105 110Phe Ser Leu Asn Ala Thr Ala Val Phe Glu Leu Thr His Ala Val Leu

115 120 125Gly Gly Met Ile Asp Arg Gly Thr Gly Ala Ile Cys Asn Val Gly Ser

130 135 140Ala Ala Gly Asn Val Pro Ile Pro Asn Asn Ala Thr Tyr Val Leu Thr145 150 155 160Lys Ala Gly Val Asn Ala Phe Thr Glu Ala Met His Tyr Glu Leu Arg

165 170 175Gly Thr Gly Val Ala Cys Thr Leu Leu Ala Pro Gly Pro Val Arg Glu

180 185 190Ala Glu Ile Pro Glu Ser Glu Lys Ser Ile Val Asp Lys Val Val Pro

195 200205Asp Phe Leu Trp Thr Thr Tyr Glu Ser Cys Ser Ala Glu Thr Leu Arg

210 215 220Ala Leu Ser Lys Asn Gln Arg Arg Val Val Pro Gly Pro Leu Ser Lys225 230 235 240Ala Met Asn Phe Val Ser Ser Val Ala Pro Thr Ala Val Leu Ser Pro

245 250 255Val Met Gly Trp Val Tyr Lys Lys Met Gly

260265<210>175<211>1293<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1270)<223>RXN02062<400>175ttgtctaaac atcgttttgg ggtccgaatg atagcccctt ttaatgcccc catttcggta 60tcgctgcgca actgttttta gatggctaat ctttgaaatt atg aga gtc gga atg 115

Met Arg Val Gly Met

1 5atg aca aga gag tat cca cca gag gtt tac ggc ggc gct ggc gtg cac 163Met Thr Arg Glu Tyr Pro Pro Glu Val Tyr Gly Gly Ala Gly Val His

10 15 20gtc acc gaa ttg acc cga ttc atg cgt gag atc gct gaa gtt gat gtt 211Val Thr Glu Leu Thr Arg Phe Met Arg Glu Ile Ala Glu Val Asp Val

25 30 35cac tgc atg ggt gca cct cgc gat atg gag gga gtt ttc gtc cac ggc 259His Cys Met Gly Ala Pro Arg Asp Met Glu Gly Val Phe Val His Gly

40 45 50gtc gat cct gcc ttg gaa agc gcg aac cct gcg att aag aca ctg tcc 307Val Asp Pro Ala Leu Glu Ser Ala Asn Pro Ala Ile Lys Thr Leu Ser

55 60 65acc ggt tta cgc atg gca gaa gct gca aac aac gtg gat gtc gtg cac 355Thr Gly Leu Arg Met Ala Glu Ala Ala Asn Asn Val Asp Val Val His 70 75 80 85tca cac act tgg tat gca ggt ctt ggc ggc cac ctt gca gct cgt ctc 403Ser His Thr Trp Tyr Ala Gly Leu Gly Gly His Leu Ala Ala Arg Leu

90 95 100cac ggc att cct cac gtg gct acc gcg cac tct ttg gag cca gat cgc 451His Gly Ile Pro His Val Ala Thr Ala His Ser Leu Glu Pro Asp Arg

105 110 115cca tgg aag cgt gag cag ctt ggc ggt gga tac gac gtg tcc tcc tgg 499Pro Trp Lys Arg Glu Gln Leu Gly Gly Gly Tyr Asp Val Ser Ser Trp

120 125 130tct gaa aaa aat gcc atg gaa tac gct gac gcg gtc atc gct gtg tcg 547Ser Glu Lys Asn Ala Met Glu Tyr Ala Asp Ala Val Ile Ala Val Ser

135 140 145gct cgc atg aaa gat tcc atc ctc gct gcg tac cct cgc atc gag ccg 595Ala Arg Met Lys Asp Ser Ile Leu Ala Ala Tyr Pro Arg Ile Glu Pro150 155 160 165gac aac gtg cgt gtt gtc ctc aac ggc atc gac act gag ttg tgg cag 643Asp Asn Val Arg Val Val Leu Asn Gly Ile Asp Thr Glu Leu Trp Gln

170 175 180cct cgc ccg act ttc gat gac gcg gaa gat tcc gta ctc cgc tcc cta 691Pro Arg Pro Thr Phe Asp Asp Ala Glu Asp Ser Val Leu Arg Ser Leu

185 190 195ggc gtt gac cca cag cgg ccc atc gtc gca ttt gtc ggc cgc atc acc 739Gly Val Asp Pro Gln Arg Pro Ile Val Ala Phe Val Gly Arg Ile Thr

200 205 210cgc caa aaa ggc gtc gag cac ctc atc aag gca gca gcg ctt ttc gac 787Arg Gln Lys Gly Val Glu His Leu Ile Lys Ala Ala Ala Leu Phe Asp

215 220 225gag tccgtg cag ctt gtg ctc tgt gcc ggc gcg cca gac acc ccc gaa 835Glu Ser Val Gln Leu Val Leu Cys Ala Gly Ala Pro Asp Thr Pro Glu230 235 240 245atc gca gct cgc acc acc gcc ctg gtg gaa gaa ctc cag gca aag cgc 883Ile Ala Ala Arg Thr Thr Ala Leu Val Glu Glu Leu Gln Ala Lys Arg

250 255 260gaa ggc att ttc tgg gtt cag gac atg ctg ggc aag gac aaa atc caa 931Glu Gly Ile Phe Trp Val Gln Asp Met Leu Gly Lys Asp Lys Ile Gln

265 270 275gag att ctc acc gct gct gac acc ttc gtg tgc cca tcc att tac gag 979Glu Ile Leu Thr Ala Ala Asp Thr Phe Val Cys Pro Ser Ile Tyr Glu

280 285 290cca ctg ggc atc gtg aac ttg gaa gca atg gcc tgc aac acc gca gtt 1027Pro Leu Gly Ile Val Asn Leu Glu Ala Met Ala Cys Asn Thr Ala Val

295 300 305gtc gca tcc gac gtt gga ggc atc cct gag gtt gtt gtc gac ggc acc 1075Val Ala Ser Asp Val Gly Gly Ile Pro Glu Val Val Val Asp Gly Thr310 315 320 325acc ggc gcc ctc gtt cac tac gac gaa aat gat gtc gaa acc ttc gag 1123Thr Gly Ala Leu Val His Tyr Asp Glu Asn Asp Val Glu Thr Phe Glu

330 335 340cgc gat atc gcc gaa gcg gtg aat aaa atg gtc gct gat cga gag acc 1171Arg Asp Ile Ala Glu Ala Val Asn Lys Met Val Ala Asp Arg Glu Thr

345 350 355gca gcc aaa ttt ggt ctc gca ggg cgc gaa cgt gct atc aat gat ttc 1219Ala Ala Lys Phe Gly Leu Ala Gly Arg Glu Arg Ala Ile Asn Asp Phe

360 365 370tcc tgg gca acg att gct cag cag acc att gat gtg tac aaa tcc ttg 1267Ser Trp Ala Thr Ile Ala Gln Gln Thr Ile Asp Val Tyr Lys Ser Leu

375380385 atg taaaaccgaa agccggggaa cct 1293Met390<210>176<211>390<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>176Met Arg Val Gly Met Met Thr Arg Glu Tyr Pro Pro Glu Val Tyr Gly 151015 Gly Ala Gly Val His Val Thr Glu Leu Thr Arg Phe Met Arg Glu Ile

20 25 30Ala Glu Val Asp Val His Cys Met Gly Ala Pro Arg Asp Met Glu Gly

35 40 45Val Phe Val His Gly Val Asp Pro Ala Leu Glu Ser Ala Asn Pro Ala

50 55 60Ile Lys Thr Leu Ser Thr Gly Leu Arg Met Ala Glu Ala Ala Asn Asn 65 70 75 80Val Asp Val Val His Ser His Thr Trp Tyr Ala Gly Leu Gly Gly His

85 90 95Leu Ala Ala Arg Leu His Gly Ile Pro His Val Ala Thr Ala His Ser

100 105 110Leu Glu Pro Asp Arg Pro Trp Lys Arg Glu Gln Leu Gly Gly Gly Tyr

115 120 125Asp Val Ser Ser Trp Ser Glu Lys Asn Ala Met Glu Tyr Ala Asp Ala

130 135 140Val Ile Ala Val Ser Ala Arg Met Lys Asp Ser Ile Leu Ala Ala Tyr145 150 155 160Pro Arg Ile Glu Pro Asp Asn Val Arg Val Val Leu Asn Gly Ile Asp

165 170 175Thr Glu Leu Trp Gln Pro Arg Pro Thr Phe Asp Asp Ala Glu Asp Ser

180 185 190Val Leu Arg Ser Leu Gly Val Asp Pro Gln Arg Pro Ile Val Ala Phe

195 200 205Val Gly Arg Ile Thr Arg Gln Lys Gly Val Glu His Leu Ile Lys Ala

210 215 220Ala Ala Leu Phe Asp Glu Ser Val Gln Leu Val Leu Cys Ala Gly Ala225 230 235 240Pro Asp Thr Pro Glu Ile Ala Ala Arg Thr Thr Ala Leu Val Glu Glu

245 250 255Leu Gln Ala Lys Arg Glu Gly Ile Phe Trp Val Gln Asp Met Leu Gly

260 265 270Lys Asp Lys Ile Gln Glu Ile Leu Thr Ala Ala Asp Thr Phe Val Cys

275 280 285Pro Ser Ile Tyr Glu Pro Leu Gly Ile Val Asn Leu Glu Ala Met Ala

290 295 300Cys Asn Thr Ala Val Val Ala Ser Asp Val Gly Gly Ile Pro Glu Val305 310 315 320Val Val Asp Gly Thr Thr Gly Ala Leu Val His Tyr Asp Glu Asn Asp

325 330 335Val Glu Thr Phe Glu Arg Asp Ile Ala Glu Ala Val Asn Lys Met Val

340 345 350Ala Asp Arg Glu Thr Ala Ala Lys Phe Gly Leu Ala Gly Arg Glu Arg

355 360 365Ala Ile Asn Asp Phe Ser Trp Ala Thr Ile Ala Gln Gln Thr Ile Asp

370375380 Val Tyr Lys Ser Leu Met 385390<210>177<211>1266<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1243)<223>RXN02148<400>177gcctcagact acggaatccc tgtgcaggtg gtatctgttg attcagcacc gttttatggt 60gcgcgtcgct actaagaaat agttcgtcag gagaatcttt gtg tct gca tcc cga 115

Val Ser Ala Ser Arg

1 5aaa act ctc gtt gtg acc aat gat ttt cct cca cgg atc ggc gga atc 163Lys Thr Leu Val Val Thr Asn Asp Phe Pro Pro Arg Ile Gly Gly Ile

10 15 20caa agc tat ttg agg gat ttc atc gct act caa gat cct gag tcg atc 211Gln Ser Tyr Leu Arg Asp Phe Ile Ala Thr Gln Asp Pro Glu Ser Ile

25 30 35gtg gtg ttt gcg tcg act caa aac gct gag gaa gcg cat gcc tac gac 259Val Val Phe Ala Ser Thr Gln Asn Ala Glu Glu Ala His Ala Tyr Asp

40 45 50aag act ttg gac tat gag gtc att agg tgg cct cgt tcg gtg atg ctg 307Lys Thr Leu Asp Tyr Glu Val Ile Arg Trp Pro Arg Ser Val Met Leu

55 60 65ccc acc cca aca acg gca cac gct atg gcg gag atc att cgt gag cga 355Pro Thr Pro Thr Thr Ala His Ala Met Ala Glu Ile Ile Arg Glu Arg 70 75 80 85gag atc gat aat gtg tgg ttc ggt gct gcg gct ccg ttg gcg ttg atg 403Glu Ile Asp Asn Val Trp Phe Gly Ala Ala Ala Pro Leu Ala Leu Met

90 95 100gca ggc aca gcg aag cag gca ggt gcg agc aag gtt att gcc tcc act 451Ala Gly Thr Ala Lys Gln Ala Gly Ala Ser Lys Val Ile Ala Ser Thr

105 110 115cat ggg cat gag gtg ggg tgg tca atg ctt cct gga tcg aga caa tcg 499His Gly His Glu Val Gly Trp Ser Met Leu Pro Gly Ser Arg Gln Ser

120 125 130ttg cgc aaa atc ggc act gag gtg gac gtg ctg act tat atc tcg cag 547Leu Arg Lys Ile Gly Thr Glu Val Asp Val Leu Thr Tyr Ile Ser Gln

135 140 145tac acg ctg cgc aga ttc aaa agt gct ttt gga tcg cac ccg act ttt 595Tyr Thr Leu Arg Arg Phe Lys Ser Ala Phe Gly Ser His Pro Thr Phe150 155 160 165gaa cat ttg cct tcc ggc gtg gac gtt aag aga ttc act ccg gcc acg 643Glu His Leu Pro Ser Gly Val Asp Val Lys Arg Phe Thr Pro Ala Thr

170 175 180cca gag gac aaa agc gca aca agg aaa aag cta gga ttc acg gac acc 691Pro Glu Asp Lys Ser Ala Thr Arg Lys Lys Leu Gly Phe Thr Asp Thr

185 190 195acc ccg gtt att gcc tgt aac tcg cgt tta gtg ccg agg aaa ggc cag 739Thr Pro Val Ile Ala Cys Asn Ser Arg Leu Val Pro Arg Lys Gly Gln

200 205 210gac tcg ctg atc aag gcg atg cca cag gtg att gcg gcg cgc cca gat 787Asp Ser Leu Ile Lys Ala Met Pro Gln Val Ile Ala Ala Arg Pro Asp

215 220 225gcg cag ttg ctc att gtg ggc agt ggg cga tac gag tcg act ttg cgg 835Ala Gln Leu Leu Ile Val Gly Ser Gly Arg Tyr Glu Ser Thr Leu Arg230 235 240 245cgc ctt gcc act gac gtg agc cag aac gtg aaa ttc ctt ggg cgc ctt 883Arg Leu Ala Thr Asp Val Ser Gln Asn Val Lys Phe Leu Gly Arg Leu

250 255 260gaa tat caa gat atg atc aac acg ctt gcc gcc gca gat att ttc gcg 931Glu Tyr Gln Asp Met Ile Asn Thr Leu Ala Ala Ala Asp Ile Phe Ala

265 270 275atg cca gcg cgc acc cgc ggt ggc gga ctt gat gtt gaa ggc ttg ggc 979Met Pro Ala Arg Thr Arg Gly Gly Gly Leu Asp Val Glu Gly Leu Gly

280 285 290att gtc tat ctc gag gca caa gcc tgc gga gtg ccg gtg ata gcc ggc 1027Ile Val Tyr Leu Glu Ala Gln Ala Cys Gly Val Pro Val Ile Ala Gly

295 300 305acc tct ggc ggc gcg cca gag acg gtg act ccg gca act ggc ctg gtt 1075Thr Ser Gly Gly Ala Pro Glu Thr Val Thr Pro Ala Thr Gly Leu Val310 315 320 325gtg gag ggg tcg gac gtc gat aag ctg tct gag ctt tta att gag ctt 1123Val Glu Gly Ser Asp Val Asp Lys Leu Ser Glu Leu Leu Ile Glu Leu

330 335 340ctc gac gat ccg atc cgc cgc gcc gcg atg ggc gct gca ggt agg gcg 1171Leu Asp Asp Pro Ile Arg Arg Ala Ala Met Gly Ala Ala Gly Arg Ala

345 350 355cat gtg gag gcc gaa tgg tcg tgg gaa atc atg ggg gag cgg ttg acc 1219His Val Glu Ala Glu Trp Ser Trp Glu Ile Met Gly Glu Arg Leu Thr

360 365 370aat att ttg cag agt gaa cca cga tgatggttgg acagctgttg ata 1266Asn Ile Leu Gln Ser Glu Pro Arg

375380<210>178<211>381<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>178Val Ser Ala Ser Arg Lys Thr Leu Val Val Thr Asn Asp Phe Pro Pro 151015 Arg Ile Gly Gly Ile Gln Ser Tyr Leu Arg Asp Phe Ile Ala Thr Gln

20 25 30Asp Pro Glu Ser Ile Val Val Phe Ala Ser Thr Gln Asn Ala Glu Glu

35 40 45Ala His Ala Tyr Asp Lys Thr Leu Asp Tyr Glu Val Ile Arg Trp Pro

50 55 60Arg Ser Val Met Leu Pro Thr Pro Thr Thr Ala His Ala Met Ala Glu 65 70 75 80Ile Ile Arg Glu Arg Glu Ile Asp Asn Val Trp Phe Gly Ala Ala Ala

85 90 95Pro Leu Ala Leu Met Ala Gly Thr Ala Lys GlnAla Gly Ala Ser Lys

100 105 110Val Ile Ala Ser Thr His Gly His Glu Val Gly Trp Ser Met Leu Pro

115 120 125Gly Ser Arg Gln Ser Leu Arg Lys Ile Gly Thr Glu Val Asp Val Leu

130 135 140Thr Tyr Ile Ser Gln Tyr Thr Leu Arg Arg Phe Lys Ser Ala Phe Gly145 150 155 160Ser His Pro Thr Phe Glu His Leu Pro Ser Gly Val Asp Val Lys Arg

165 170 175Phe Thr Pro Ala Thr Pro Glu Asp Lys Ser Ala Thr Arg Lys Lys Leu

180 185 190Gly Phe Thr Asp Thr Thr Pro Val Ile Ala Cys Asn Ser Arg Leu Val

195 200 205Pro Arg Lys Gly Gln Asp Ser Leu Ile Lys Ala Met Pro Gln Val Ile

210 215 220Ala Ala Arg Pro Asp Ala Gln Leu Leu Ile Val Gly Ser Gly Arg Tyr225 230 235 240Glu Ser Thr Leu Arg Arg Leu Ala Thr Asp Val Ser Gln Asn Val Lys

245 250 255Phe Leu Gly Arg Leu Glu Tyr Gln Asp Met Ile Asn Thr Leu Ala Ala

260 265 270Ala Asp Ile Phe Ala Met Pro Ala Arg Thr Arg Gly Gly Gly Leu Asp

275 280 285Val Glu Gly Leu Gly Ile Val Tyr Leu Glu Ala Gln Ala Cys Gly Val

290 295 300Pro Val Ile Ala Gly Thr Ser Gly Gly Ala Pro Glu Thr Val Thr Pro305 310 315 320Ala Thr Gly Leu Val Val Glu Gly Ser Asp Val Asp Lys Leu SerGlu

325 330 335Leu Leu Ile Glu Leu Leu Asp Asp Pro Ile Arg Arg Ala Ala Met Gly

340 345 350Ala Ala Gly Arg Ala His Val Glu Ala Glu Trp Ser Trp Glu Ile Met

355 360 365Gly Glu Arg Leu Thr Asn Ile Leu Gln Ser Glu Pro Arg

370375380<210>179<211>1287<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1264)<223>RXN02595<400>179gtgggtaaag gggactccga ggaagtccac gtcgtcttct ttcgcggcgc tgaggatggt 60ttcgcggatt tgtgcggggg agtgggtggg agagaaaacg gtg atc gtt gtg gcc 115

Val Ile Val Val Ala

1 5atg gct tcc att atg gct tgt tta aaa gca gct aga ctg aat aac cct 163Met Ala Ser Ile Met Ala Cys Leu Lys Ala Ala Arg Leu Asn Asn Pro

10 15 20atg aag atc ctt ttg ttg tgc tgg cgt gat acc act cat cct caa ggt 211Met Lys Ile Leu Leu Leu Cys Trp Arg Asp Thr Thr His Pro Gln Gly

25 30 35ggc gga agt gaa cgc tat ctg gag cgg gtg ggt gag ttt ttg gcg gat 259Gly Gly Ser Glu Arg Tyr Leu Glu Arg Val Gly Glu Phe Leu Ala Asp

40 45 50cag ggc cat gag gtg gtg ttt cgt act gct ggg cac acg gat gcg cca 307Gln Gly His Glu Val Val Phe Arg Thr Ala Gly His Thr Asp Ala Pro

55 60 65cgg cgt tct ttc cgc gat ggt gtg agg tat tcc agg agc ggt ggg aag 355Arg Arg Ser Phe Arg Asp Gly Val Arg Tyr Ser Arg Ser Gly Gly Lys7075 80 85ttt agt gtg tat ccc aag gcg tgg gtg gcc atg atg ttg ggt cgt gtg 403Phe Ser Val Tyr Pro Lys Ala Trp Val Ala Met Met Leu Gly Arg Val

90 95 100ggg att ggc acg ttt tcc aag gtt gat gtg gtg gtg gat acg cag aat 451Gly Ile Gly Thr Phe Ser Lys Val Asp Val Val Val Asp Thr Gln Asn

105 110 115ggc att ccg ttt ttt gga aag ttt ttc tcc ggt aag ccg act gtg ttg 499Gly Ile Pro Phe Phe Gly Lys Phe Phe Ser Gly Lys Pro Thr Val Leu

120 125 130ctc acg cat cat tgc cat aag gag cag tgg ccg gtg gtg ggt cgg gtg 547Leu Thr His His Cys His Lys Glu Gln Trp Pro Val Val Gly Arg Val

135 140 145ctg gcg aag gtt ggt tgg ctg att gag agc cag atc gcg ccg cgc gct 595Leu Ala Lys Val Gly Trp Leu Ile Glu Ser Gln Ile Ala Pro Arg Ala150 155 160 165tac aaa act gcg ccg tat gtg act gtt tca gag ccg agc gct gag gag 643Tyr Lys Thr Ala Pro Tyr Val Thr Val Ser Glu Pro Ser Ala Glu Glu

170 175 180ctc att gcg ttg ggt gtg gat cag cag cgg att cat atc gtg cgc aat 691Leu Ile Ala Leu Gly Val Asp Gln Gln Arg Ile His Ile Val Arg Asn

185 190 195ggc gtg gat ccc gtg ccg ctg cac acg ccg aag ctg gat cgc gat ggc 739Gly Val Asp Pro yal Pro Leu His Thr Pro Lys Leu Asp Arg Asp Gly

200 205 210cag cat gcg gtg acg ttg tcg cgc ctg gtt ccg cac aag cag att gag 787Gln His Ala Val Thr Leu Ser Arg Leu Val Pro His Lys Gln Ile Glu

215 220 225cat gcg atg gat gtc gtc gcg gcg ctc gac ggc gtg gtg ctg gat gta 835His Ala Met Asp Val Val Ala Ala Leu Asp Gly Val Val Leu Asp Val230 235 240 245gtc gaa agc ggt tgg tgg cag aag gaa ctg gtc gat tat gcc cgc acg 883Val Glu Ser Gly Trp Trp Gln Lys Glu Leu Val Asp Tyr Ala Arg Thr

250 255 260ctg ggt gtg agc gat cgc gtg gtt ttc cac ggc cag gtc gcc gag gat 931Leu Gly Val Ser Asp Arg Val Val Phe His Gly Gln Val Ala Glu Asp

265 270 275cac aag cac gcc ctg ttg gag cgc gcc acg att cat ctc atg cct tcg 979His Lys His Ala Leu Leu Glu Arg Ala Thr Ile His Leu Met Pro Ser

280 285 290cgc aag gaa ggc tgg ggc ctg gcg gtc acg gag gcg gcg cag cac ggc 1027Arg Lys Glu Gly Trp Gly Leu Ala Val Thr Glu Ala Ala Gln His Gly

295 300 305gtt ccg acg atc ggt tac cga agc tca ggc ggc ctg cgc gat tcc gtc 1075Val Pro Thr Ile Gly Tyr Arg Ser Ser Gly Gly Leu Arg Asp Ser Val310 315 320 325gtc gac ggc gaa acc ggc ctg ctt gtc gac tcc aag gcc gag ctt att 1123Val Asp Gly Glu Thr Gly Leu Leu Val Asp Ser Lys Ala Glu Leu Ile

330 335 340tca gcc acc aaa acc ctg ctt atc gac gcc tcc ctc cgc tcc aag ctc 1171Ser Ala Thr Lys Thr Leu Leu Ile Asp Ala Ser Leu Arg Ser Lys Leu

345 350 355ggc gcc agc gcg aag cag cgc gcc gaa aac tac aag tgg gac acc gcg 1219Gly Ala Ser Ala Lys Gln Arg Ala Glu Asn Tyr Lys Trp Asp Thr Ala

360 365 370gga gcg cag ttc gag gaa cta ctt ctt ggt ctt gcg tcg aaa aag 1264Gly Ala Gln Phe Glu Glu Leu Leu Leu Gly Leu Ala Ser Lys Lys

375380385 tagtcccagc ggcaacgcca tcc 1287<210>180<211>388<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>180Val Ile Val Val Ala Met Ala Ser Ile Met Ala Cys Leu Lys Ala Ala 151015 Arg Leu Asn Asn Pro Met Lys Ile Leu Leu Leu Cys Trp Arg Asp Thr

20 25 30Thr His Pro Gln Gly Gly Gly Ser Glu Arg Tyr Leu Glu Arg Val Gly

35 40 45Glu Phe Leu Ala Asp Gln Gly His Glu Val Val Phe Arg Thr Ala Gly

50 55 60His Thr Asp Ala Pro Arg Arg Ser Phe Arg Asp Gly Val Arg Tyr Ser 65 70 75 80Arg Ser Gly Gly Lys Phe Ser Val Tyr Pro Lys Ala Trp Val Ala Met

85 90 95Met Leu Gly Arg Val Gly Ile Gly Thr Phe Ser Lys Val Asp Val Val

100 105 110Val Asp Thr Gln Asn Gly Ile Pro Phe Phe Gly Lys Phe Phe Ser Gly

115 120 125Lys Pro Thr Val Leu Leu Thr His His Cys His Lys Glu Gln Trp Pro

130 135 140Val Val Gly Arg Val Leu Ala Lys Val Gly Trp Leu Ile Glu Ser Gln145 150 155 160Ile Ala Pro Arg Ala Tyr Lys Thr Ala Pro Tyr Val Thr Val Ser Glu

165 170 175Pro Ser Ala Glu Glu Leu Ile Ala Leu Gly Val Asp Gln Gln Arg Ile

180 185 190His Ile Val Arg Asn Gly Val Asp Pro Val Pro Leu His Thr Pro Lys

195 200 205Leu Asp Arg Asp Gly Gln His Ala Val Thr LeuSer Arg Leu Val Pro

210 215 220His Lys Gln Ile Glu His Ala Met Asp Val Val Ala Ala Leu Asp Gly225 230 235 240Val Val Leu Asp Val Val Glu Ser Gly Trp Trp Gln Lys Glu Leu Val

245 250 255Asp Tyr Ala Arg Thr Leu Gly Val Ser Asp Arg Val Val Phe His Gly

260 265 270Gln Val Ala Glu Asp His Lys His Ala Leu Leu Glu Arg Ala Thr Ile

275 280 285His Leu Met Pro Ser Arg Lys Glu Gly Trp Gly Leu Ala Val Thr Glu

290 295 300Ala Ala Gln His Gly Val Pro Thr Ile Gly Tyr Arg Ser Ser Gly Gly305 310 315 320Leu Arg Asp Ser Val Val Asp Gly Glu Thr Gly Leu Leu Val Asp Ser

325 330 335Lys Ala Glu Leu Ile Ser Ala Thr Lys Thr Leu Leu Ile Asp Ala Ser

340 345 350Leu Arg Ser Lys Leu Gly Ala Ser Ala Lys Gln Arg Ala Glu Asn Tyr

355 360 365Lys Trp Asp Thr Ala Gly Ala Gln Phe Glu Glu Leu Leu Leu Gly Leu

370375380 Ala Ser Lys Lys385<210>181<211>2334<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (2311)<223>RXS00148<400>181ctttgagggc agcgcgcatg cgcccgatgg ttatttgaac atgacaattg atgccgcggc 60gacgctggct gacctgctag atgctttggg agcttaaatc atg acg tcg atc cct 115

Met Thr Ser Ile Pro

1 5aat ttt tca gac atc cca ttg act gct gag aca cgt gca tcg gag tca 163Asn Phe Ser Asp Ile Pro Leu Thr Ala Glu Thr Arg Ala Ser Glu Ser

10 15 20cac aac gtt gac gcc ggc aag gtg tgg aac act ccc gaa ggc att gat 211His Asn Val Asp Ala Gly Lys Val Trp Asn Thr Pro Glu Gly Ile Asp

25 30 35gtc aag cgc gta ttc acg cag gct gac cgc gac gag gcg caa gcg gcg 259Val Lys Arg Val Phe Thr Gln Ala Asp Arg Asp Glu Ala Gln Ala Ala

40 45 50gga cat ccg gtg gat tct ttg cca ggt caa aag cca ttt atg cgc ggg 307Gly His Pro Val Asp Ser Leu Pro Gly Gln Lys Pro Phe Met Arg Gly

55 60 65ccg tac cca act atg tac acc aat cag ccg tgg acg att cgc cag tac 355Pro Tyr Pro Thr Met Tyr Thr Asn Gln Pro Trp Thr Ile Arg Gln Tyr 70 75 80 85gca ggc ttt tca acc gcc gcg gaa tcc aat gcg ttt tat cgg agg aac 403Ala Gly Phe Ser Thr Ala Ala Glu Ser Asn Ala Phe Tyr Arg Arg Asn

90 95 100ctt gct gcg ggt caa aaa ggt ttg tcg gtt gcg ttc gat cta gcg acc 451Leu Ala Ala Gly Gln Lys Gly Leu Ser Val Ala Phe Asp Leu Ala Thr

105 110 115cac cgc ggt tat gac tcg gat aat gag cgc gtg gtc ggc gat gtg ggt 499His Arg Gly Tyr Asp Ser Asp Asn Glu Arg Val Val Gly Asp Val Gly

120 125 130atg gcc ggc gtg gcg att gat tcg att ttg gat atg cgt cag ctg ttt 547Met Ala Gly Val Ala Ile Asp Ser Ile Leu Asp Met Arg Gln Leu Phe

135 140 145gat ggc att gat ttg tcc agc gtg tcg gtg tcg atg acc atg aat ggc 595Asp Gly Ile Asp Leu Ser Ser Val Ser Val Ser Met Thr Met Asn Gly150 155 160 165gct gtg ctg ccg att ctt gcg ttc tat atc gtg gcg gct gag gaa caa 643Ala Val Leu Pro Ile Leu Ala Phe Tyr Ile Val Ala Ala Glu Glu Gln

170 175 180ggt gtg ggt ccg gag cag ctt gcg ggc acg atc cag aat gac atc ttg 691Gly Val Gly Pro Glu Gln Leu Ala Gly Thr Ile Gln Asn Asp Ile Leu

185 190 195aaa gaa ttt atg gtg cgc aac acc tat att tat ccg ccg aag ccg tcg 739Lys Glu Phe Met Val Arg Asn Thr Tyr Ile Tyr Pro Pro Lys Pro Ser

200 205 210atg cgc atc att tcc aac atc ttt gag tac acc tcc ttg aag atg cca 787Met Arg Ile Ile Ser Asn Ile Phe Glu Tyr Thr Ser Leu Lys Met Pro

215 220 225cgt ttt aac tcc att tcg att tct ggc tat cac atc cag gaa gcg gga 835Arg Phe Asn Ser Ile Ser Ile Ser Gly Tyr His Ile Gln Glu Ala Gly230 235 240 245gcg act gcc gat ttg gag ctg gcc tac act ctg gcg gat ggt att gaa 883Ala Thr Ala Asp Leu Glu Leu Ala Tyr Thr Leu Ala Asp Gly Ile Glu

250 255 260tac atc cgt gca ggt aaa gag gta ggc ctt gac gtg gat aag ttc gcg 931Tyr Ile Arg Ala Gly Lys Glu Val Gly Leu Asp Val Asp Lys Phe Ala

265 270 275cct cgt ctg tcc ttc ttc tgg ggt att tct atg tac acc ttc atg gag 979Pro Arg Leu Ser Phe Phe Trp Gly Ile Ser Met Tyr Thr Phe Met Glu

280 285 290atc gca aag ctg cgt gcg gga cga ctg ctg tgg agc gag ttg gtg gca 1027Ile Ala Lys Leu Arg Ala Gly Arg Leu Leu Trp Ser Glu Leu Val Ala

295300 305aaa ttc gat ccg aaa aac gcc aag tcc cag tcg ctg cgc acg cac tcg 1075Lys Phe Asp Pro Lys Asn Ala Lys Ser Gln Ser Leu Arg Thr His Ser310 315 320 325cag acc tct ggt tgg tcg ttg acc gcg cag gat gtg tac aac aac gtc 1123Gln Thr Ser Gly Trp Ser Leu Thr Ala Gln Asp Val Tyr Asn Asn Val

330 335 340gcc cgc acc gcg att gag gcg atg gct gca acc cag ggc cac acc cag 1171Ala Arg Thr Ala Ile Glu Ala Met Ala Ala Thr Gln Gly His Thr Gln

345 350 355tcg ctg cac acc aat gca ctt gat gag gcg ttg gcg ctg ccc acc gat 1219Ser Leu His Thr Asn Ala Leu Asp Glu Ala Leu Ala Leu Pro Thr Asp

360 365 370ttc tct gct cgt atc gcc cga aac acc cag ctg ttg ctg cag cag gaa 1267Phe Ser Ala Arg Ile Ala Arg Asn Thr Gln Leu Leu Leu Gln Gln Glu

375 380 385tct ggc acg gtg cgt cca gtt gat cca tgg gcg ggc tcc tat tac gtg 1315Ser Gly Thr Val Arg Pro Val Asp Pro Trp Ala Gly Ser Tyr Tyr Val390 395 400 405gag tgg ttg acc aat gag ctg gct aac cgc gcg cgc aag cac atc gat 1363Glu Trp Leu Thr Asn Glu Leu Ala Asn Arg Ala Arg Lys His Ile Asp

410 415 420gag gtg gag gaa gcc ggc gga atg gcg cag gcc acc gcg cag gga att 1411Glu Val Glu Glu Ala Gly Gly Met Ala Gln Ala Thr Ala Gln Gly Ile

425 430 435cct aag ctg cgc att gag gaa tca gcg gca cgc acc cag gct cgc att 1459Pro Lys Leu Arg Ile Glu Glu Ser Ala Ala Arg Thr Gln Ala Arg Ile

440 445 450gat tcc ggc cgc cag gcg ctg atc ggc gtg aat cgc tac gtg gcg gaa 1507AspSer Gly Arg Gln Ala Leu Ile Gly Val Asn Arg Tyr Val Ala Glu

455 460 465gaa gat gag gaa att gaa gtc ctc aag gtt gac aac acc aag gtt cgc 1555Glu Asp Glu Glu Ile Glu Val Leu Lys Val Asp Asn Thr Lys Val Arg470 475 480 485gca gaa cag ttg gct aaa ctc gcg caa ctg aaa gca gag cgc aac gat 1603Ala Glu Gln Leu Ala Lys Leu Ala Gln Leu Lys Ala Glu Arg Asn Asp

490 495 500gcg gaa gtc aag gct gcg ctg gat gcg ttg aca gct gct gcc cgc aac 1651Ala Glu Val Lys Ala Ala Leu Asp Ala Leu Thr Ala Ala Ala Arg Asn

505 510 515gag cat aaa gag cca ggg gat ttg gat cag aac ctg ctc aaa ctt gcc 1699Glu His Lys Glu Pro Gly Asp Leu Asp Gln Asn Leu Leu Lys Leu Ala

520 525 530gtc gat gct gcg cgc gca aaa gct acc att gga gag atc tcc gat gct 1747Val Asp Ala Ala Arg Ala Lys Ala Thr Ile Gly Glu Ile Ser Asp Ala

535 540 545ttg gaa gtt gtc ttt ggc cgc cac gaa gca gaa atc agg acg ctg tct 1795Leu Glu Val Val Phe Gly Arg His Glu Ala Glu Ile Arg Thr Leu Ser550 555 560 565ggc gtg tac aag gat gag gtt gga aag gaa ggc aca gtg agc aac gtc 1843Gly Val Tyr Lys Asp Glu Val Gly Lys Glu Gly Thr Val Ser Asn Val

570 575 580gaa cgc gcg atc gcc ctg gct gac gcc ttt gag gct gag gaa ggc cgc 1891Glu Arg Ala Ile Ala Leu Ala Asp Ala Phe Glu Ala Glu Glu Gly Arg

585 590 595cgc cca cgt atc ttt att gcc aag atg ggc cag gat gga cat gac cgt 1939Arg Pro Arg Ile Phe Ile Ala Lys Met Gly Gln Asp Gly His Asp Arg

600 605 610gga cag aag gtt gtc gcg tct gcc tat gct gac ctg ggc atg gac gtg 1987Gly Gln Lys Val Val Ala Ser Ala Tyr Ala Asp Leu Gly Met Asp Val

615 620 625gat gtt gga ccg ctg ttt caa act cca gcc gaa gct gcc cgc gcc gcc 2035Asp Val Gly Pro Leu Phe Gln Thr Pro Ala Glu Ala Ala Arg Ala Ala630 635 640 645gtg gac gcc gat gtt cac gtg gtg ggt atg tct tcg ctg gca gca ggc 2083Val Asp Ala Asp Val His Val Val Gly Met Ser Ser Leu Ala Ala Gly

650 655 660cac ctc acc ttg ctg ccc gag ctg aag aaa gaa ctt gca gct ctt ggc 2131His Leu Thr Leu Leu Pro Glu Leu Lys Lys Glu Leu Ala Ala Leu Gly

665 670 675cgc gat gac att ctg gtc acc gtg ggc ggc gtc att ccg ccg ggc gat 2179Arg Asp Asp Ile Leu Val Thr Val Gly Gly Val Ile Pro Pro Gly Asp

680 685 690ttc cag gat ctc tac gat atg ggt gcc gcc gcg att tac cct tca gga 2227Phe Gln Asp Leu Tyr Asp Met Gly Ala Ala Ala Ile Tyr Pro Ser Gly

695 700 705acc gtc atc gcg gag tcg gcg atc gat ctg atc acc cga ctc gcc gca 2275Thr Val Ile Ala Glu Ser Ala Ile Asp Leu Ile Thr Arg Leu Ala Ala710 715 720 725cac ctg ggc ttt gac ctg gat gtg gat gtg aat gaa tgatcacggt 2321His Leu Gly Phe Asp Leu Asp Val Asp Val Asn Glu

730735 ttcctagaag aca 2334<210>182<211>737<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>182Met Thr Ser Ile Pro Asn Phe Ser Asp Ile Pro Leu Thr Ala Glu Thr 151015 Arg Ala Ser Glu Ser His Asn Val Asp Ala Gly Lys Val Trp Asn Thr

2025 30Pro Glu Gly Ile Asp Val Lys Arg Val Phe Thr Gln Ala Asp Arg Asp

35 40 45Glu Ala Gln Ala Ala Gly His Pro Val Asp Ser Leu Pro Gly Gln Lys

50 55 60Pro Phe Met Arg Gly Pro Tyr Pro Thr Met Tyr Thr Asn Gln Pro Trp 65 70 75 80Thr Ile Arg Gln Tyr Ala Gly Phe Ser Thr Ala Ala Glu Ser Asn Ala

85 90 95Phe Tyr Arg Arg Asn Leu Ala Ala Gly Gln Lys Gly Leu Ser Val Ala

100 105 110Phe Asp Leu Ala Thr His Arg Gly Tyr Asp Ser Asp Asn Glu Arg Val

115 120 125Val Gly Asp Val Gly Met Ala Gly Val Ala Ile Asp Ser Ile Leu Asp

130 135 140Met Arg Gln Leu Phe Asp Gly Ile Asp Leu Ser Ser Val Ser Val Ser145 150 155 160Met Thr Met Asn Gly Ala Val Leu Pro Ile Leu Ala Phe Tyr Ile Val

165 170 175Ala Ala Glu Glu Gln Gly Val Gly Pro Glu Gln Leu Ala Gly Thr Ile

180 185 190Gln Asn Asp Ile Leu Lys Glu Phe Met Val Arg Asn Thr Tyr Ile Tyr

195 200 205Pro Pro Lys Pro Ser Met Arg Ile Ile Ser Asn Ile Phe Glu Tyr Thr

210 215 220Ser Leu Lys Met Pro Arg Phe Asn Ser Ile Ser Ile Ser Gly Tyr His225 230 235 240Ile Gln Glu Ala Gly Ala Thr Ala Asp Leu Glu Leu Ala Tyr Thr Leu

245 250 255Ala Asp Gly Ile Glu Tyr Ile Arg Ala Gly Lys Glu Val Gly Leu Asp

260 265 270Val Asp Lys Phe Ala Pro Arg Leu Ser Phe Phe Trp Gly Ile Ser Met

275 280 285Tyr Thr Phe Met Glu Ile Ala Lys Leu Arg Ala Gly Arg Leu Leu Trp

290 295 300Ser Glu Leu Val Ala Lys Phe Asp Pro Lys Asn Ala Lys Ser Gln Ser305 310 315 320Leu Arg Thr His Ser Gln Thr Ser Gly Trp Ser Leu Thr Ala Gln Asp

325 330 335Val Tyr Asn Asn Val Ala Arg Thr Ala Ile Glu Ala Met Ala Ala Thr

340 345 350Gln Gly His Thr Gln Ser Leu His Thr Asn Ala Leu Asp Glu Ala Leu

355 360 365Ala Leu Pro Thr Asp Phe Ser Ala Arg Ile Ala Arg Asn Thr Gln Leu

370 375 380Leu Leu Gln Gln Glu Ser Gly Thr Val Arg Pro Val Asp Pro Trp Ala385 390 395 400Gly Ser Tyr Tyr Val Glu Trp Leu Thr Asn Glu Leu Ala Asn Arg Ala

405 410 415Arg Lys His Ile Asp Glu Val Glu Glu Ala Gly Gly Met Ala Gln Ala

420 425 430Thr Ala Gln Gly Ile Pro Lys Leu Arg Ile Glu Glu Ser Ala Ala Arg

435 440 445Thr Gln Ala Arg Ile Asp Ser Gly Arg Gln Ala Leu Ile Gly Val Asn

450 455 460Arg Tyr Val Ala Glu Glu Asp Glu Glu Ile Glu Val Leu Lys Val Asp465 470 475 480Asn Thr Lys Val Arg Ala Glu Gln Leu AlaLys Leu Ala Gln Leu Lys

485 490 495Ala Glu Arg Asn Asp Ala Glu Val Lys Ala Ala Leu Asp Ala Leu Thr

500 505 510Ala Ala Ala Arg Asn Glu His Lys Glu Pro Gly Asp Leu Asp Gln Asn

515 520 525Leu Leu Lys Leu Ala Val Asp Ala Ala Arg Ala Lys Ala Thr Ile Gly

530 535 540Glu Ile Ser Asp Ala Leu Glu Val Val Phe Gly Arg His Glu Ala Glu545 550 555 560Ile Arg Thr Leu Ser Gly Val Tyr Lys Asp Glu Val Gly Lys Glu Gly

565 570 575Thr Val Ser Asn Val Glu Arg Ala Ile Ala Leu Ala Asp Ala Phe Glu

580 585 590Ala Glu Glu Gly Arg Arg Pro Arg Ile Phe Ile Ala Lys Met Gly Gln

595 600 605Asp Gly His Asp Arg Gly Gln Lys Val Val Ala Ser Ala Tyr Ala Asp

610 615 620Leu Gly Met Asp Val Asp Val Gly Pro Leu Phe Gln Thr Pro Ala Glu625 630 635 640Ala Ala Arg Ala Ala Val Asp Ala Asp Val His Val Val Gly Met Ser

645 650 655Ser Leu Ala Ala Gly His Leu Thr Leu Leu Pro Glu Leu Lys Lys Glu

660 665 670Leu Ala Ala Leu Gly Arg Asp Asp Ile Leu Val Thr Val Gly Gly Val

675 680 685Ile Pro Pro Gly Asp Phe Gln Asp Leu Tyr Asp Met Gly Ala Ala Ala

690 695 700Ile Tyr Pro Ser Gly Thr ValIle Ala Glu Ser Ala Ile Asp Leu Ile705 710 715 720Thr Arg Leu Ala Ala His Leu Gly Phe Asp Leu Asp Val Asp Val Asn

725730735 Glu<210>183<211>1971<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1948)<223>RXS00149<400>183ttttcgtagg taaacacagg tgaaggcttt acaagcttgt gaactcccta cacaaaagca 60atccaatagc tatccataag caagagaaag taagtctacg ttg act gat ctc aca 115

Leu Thr Asp Leu Thr

1 5aag act gcg gtg ccc gag gaa ctt tca gag aac ctc gaa act tgg tac 163Lys Thr Ala Val Pro Glu Glu Leu Ser Glu Asn Leu Glu Thr Trp Tyr

10 15 20aag gct gtg gcc ggt gtt ttc gcg cgc aca cag aaa aaa gac atc ggc 211Lys Ala Val Ala Gly Val Phe Ala Arg Thr Gln Lys Lys Asp Ile Gly

25 30 35gac att gcc gta gat gtg tgg aag aaa ctc atc gtc act aca ccg gat 259Asp Ile Ala Val Asp Val Trp Lys Lys Leu Ile Val Thr Thr Pro Asp

40 45 50ggt gtt gat atc aat ccg ctg tac acc aga gca gat gag tcc cag agg 307Gly Val Asp Ile Asn Pro Leu Tyr Thr Arg Ala Asp Glu Ser Gln Arg

55 60 65aaa ttc act gag gtt cct ggt gag ttt ccc ttc act agg gga acc act 355Lys Phe Thr Glu Val Pro Gly Glu Phe Pro Phe Thr Arg Gly Thr Thr70 75 80 85gtt gat ggt gaa cgc gtt ggt tgg ggt gtt act gag act ttc gga cat 403Val Asp Gly Glu Arg Val Gly Trp Gly Val Thr Glu Thr Phe Gly His

90 95 100gac agc ccg aag aat atc aac gct gcg gtg ctg aat gct ctg aat tct 451Asp Ser Pro Lys Asn Ile Asn Ala Ala Val Leu Asn Ala Leu Asn Ser

105 110 115ggc acc acc aca ttg ggt ttt gag ttc tct gag gaa ttc acg gca gct 499Gly Thr Thr Thr Leu Gly Phe Glu Phe Ser Glu Glu Phe Thr Ala Ala

120 125 130gat ctt aaa gtt gct ctc gaa ggc gtg tat ctc aac atg gct ccg ttg 547Asp Leu Lys Val Ala Leu Glu Gly Val Tyr Leu Asn Met Ala Pro Leu

135 140 145ctg att cat gcg ggt gga tcc acg tca gag gtt gca gcg gcg ttg tat 595Leu Ile His Ala Gly Gly Ser Thr Ser Glu Val Ala Ala Ala Leu Tyr150 155 160 165acg ttg gcg gag gaa gcc gga acg ttt ttt gct gcg ttg acc ttg ggt 643Thr Leu Ala Glu Glu Ala Gly Thr Phe Phe Ala Ala Leu Thr Leu Gly

170 175 180tct cgt cct ttg acg gcg cag gtt gat ggt tcg cac agt gac acc att 691Ser Arg Pro Leu Thr Ala Gln Val Asp Gly Ser His Ser Asp Thr Ile

185 190 195gaa gaa gca gtt cag ttg gca gtg aat gct tcc aag cgt gcg aat gtg 739Glu Glu Ala Val Gln Leu Ala Val Asn Ala Ser Lys Arg Ala Asn Val

200 205 210cgc gct atc ttg gtg gat ggt tcc agt ttt tcc aac cag ggc gcg tcg 787Arg Ala Ile Leu Val Asp Gly Ser Ser Phe Ser Asn Gln Gly Ala Ser

215 220 225gat gct caa gaa att ggt cta agt atc gcc gcc ggt gtg gat tat gtc 835Asp Ala Gln Glu Ile Gly Leu Ser Ile Ala Ala Gly Val Asp Tyr Val230 235 240 245cgt cgc ttg gtc gat gca ggc ctt tcc acg gaa gct gca ctt aag cag 883Arg Arg Leu Val Asp Ala Gly Leu Ser Thr Glu Ala Ala Leu Lys Gln

250 255 260gtg gcg ttc cgt ttt gcg gtc acc gat gag cag ttc gcg cag att tct 931Val Ala Phe Arg Phe Ala Val Thr Asp Glu Gln Phe Ala Gln Ile Ser

265 270 275aag ctg cgt gtg gct cga cgt ctg tgg gcc agg gtg tgt gag gtg ctt 979Lys Leu Arg Val Ala Arg Arg Leu Trp Ala Arg Val Cys Glu Val Leu

280 285 290ggt ttt cca gag ctg gcc gta gca cca cag cat gcg gtg act gca cga 1027Gly Phe Pro Glu Leu Ala Val Ala Pro Gln His Ala Val Thr Ala Arg

295 300 305gcg atg ttt agc cag cgt gat ccg tgg gtg aat atg ctg cgc agt act 1075Ala Met Phe Ser Gln Arg Asp Pro Trp Val Asn Met Leu Arg Ser Thr310 315 320 325gtt gca gct ttc gct gca ggc gtc ggt gga gca acc gat gtg gag gtt 1123Val Ala Ala Phe Ala Ala Gly Val Gly Gly Ala Thr Asp Val Glu Val

330 335 340cgt act ttt gat gat gcg atc cca gat gga gtt cct gga gtg tcg agg 1171Arg Thr Phe Asp Asp Ala Ile Pro Asp Gly Val Pro Gly Val Ser Arg

345 350 355aat ttc gct cac cgc atc gcg cgc aat act aat ttg ttg ttg cta gaa 1219Asn Phe Ala His Arg Ile Ala Arg Asn Thr Asn Leu Leu Leu Leu Glu

360 365 370gag tca cat ctt ggt cac gtg gtt gat cct gct ggt gga tca tat ttc 1267Glu Ser His Leu Gly His Val Val Asp Pro Ala Gly Gly Ser Tyr Phe

375 380 385gtg gag agc ttc acc gat gat cta gcg gag aag gcg tgg gct gtg ttc 1315Val Glu Ser Phe Thr Asp Asp Leu Ala Glu Lys Ala Trp Ala Val Phe390 395 400 405agt ggc atc gaa gct gag ggc gga tac agt gca gct tgt gca tcc ggc 1363Ser Gly Ile Glu Ala Glu Gly Gly Tyr Ser Ala Ala Cys Ala Ser Gly

410 415 420acg gtg act gcc atg ctt gat cag acg tgg gag cag act cgc gct gat 1411Thr Val Thr Ala Met Leu Asp Gln Thr Trp Glu Gln Thr Arg Ala Asp

425 430 435gtg gcg tcg aga aag aag aag ctc act gga att aat gag ttc ccg aac 1459Val Ala Ser Arg Lys Lys Lys Leu Thr Gly Ile Asn Glu Phe Pro Asn

440 445 450ttg gcg gag tct ccg ctg cca gct gat cgt cgg gta gaa cct gca ggt 1507Leu Ala Glu Ser Pro Leu Pro Ala Asp Arg Arg Val Glu Pro Ala Gly

455 460 465gtg cgt cga tgg gca gcg gat ttt gaa gcg ctg cgc aat cgt tcg gat 1555Val Arg Arg Trp Ala Ala Asp Phe Glu Ala Leu Arg Asn Arg Ser Asp470 475 480 485gct ttc ttg gaa aag aac ggc gcg agg cca cag atc acg atg att cct 1603Ala Phe Leu Glu Lys Asn Gly Ala Arg Pro Gln Ile Thr Met Ile Pro

490 495 500ctg gga ccg ttg tcc aag cac aat att cgc act ggt ttt act tcc aac 1651Leu Gly Pro Leu Ser Lys His Asn Ile Arg Thr Gly Phe Thr Ser Asn

505 510 515ctg ttg gct tcc ggt ggc att gaa gca atc aac ccg ggt caa ctt gtt 1699Leu Leu Ala Ser Gly Gly Ile Glu Ala Ile Asn Pro Gly Gln Leu Val

520 525 530ccc ggc act gac gct ttt gca gaa gct gca cag gcc gca ggc att gta 1747Pro Gly Thr Asp Ala Phe Ala Glu Ala Ala Gln Ala Ala Gly Ile Val

535 540 545gtg gtg tgt gga acg gac caa gag tat gcc gaa acg ggg gag gga gcc 1795Val Val Cys Gly Thr Asp Gln Glu Tyr Ala Glu Thr Gly Glu Gly Ala550 555 560 565gtc gaa aag ctc cgc gaa gcg ggc gtt gag cgc atc ctg ctt gct ggc 1843Val Glu Lys Leu Arg Glu Ala Gly Val Glu Arg Ile Leu Leu Ala Gly

570 575 580gcg ccg aag agc ttt gag ggc agc gcg cat gcg ccc gat ggt tat ttg 1891Ala Pro Lys Ser Phe Glu Gly Ser Ala His Ala Pro Asp Gly Tyr Leu

585 590 595aac atg aca att gat gcc gcg gcg acg ctg gct gac ctg cta gat gct 1939Asn Met Thr Ile Asp Ala Ala Ala Thr Leu Ala Asp Leu Leu Asp Ala

600 605 610ttg gga gct taaatcatga cgtcgatccc taa 1971Leu Gly Ala

615<210>184<211>616<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>184Leu Thr Asp Leu Thr Lys Thr Ala Val Pro Glu Glu Leu Ser Glu Asn 151015 Leu Glu Thr Trp Tyr Lys Ala Val Ala Gly Val Phe Ala Arg Thr Gln

20 25 30Lys Lys Asp Ile Gly Asp Ile Ala Val Asp Val Trp Lys Lys Leu Ile

35 40 45Val Thr Thr Pro Asp Gly Val Asp Ile Asn Pro Leu Tyr Thr Arg Ala

50 55 60Asp Glu Ser Gln Arg Lys Phe Thr Glu Val Pro Gly Glu Phe Pro Phe 65 70 75 80Thr Arg Gly Thr Thr Val Asp Gly Glu Arg Val Gly Trp Gly Val Thr

85 90 95Glu Thr Phe Gly His Asp Ser Pro Lys Asn Ile Asn Ala Ala Val Leu

100 105 110Asn Ala Leu Asn Ser Gly Thr Thr Thr Leu Gly Phe Glu Phe Ser Glu

115120 125Glu Phe Thr Ala Ala Asp Leu Lys Val Ala Leu Glu Gly Val Tyr Leu

130 135 140Asn Met Ala Pro Leu Leu Ile His Ala Gly Gly Ser Thr Ser Glu Val145 150 155 160Ala Ala Ala Leu Tyr Thr Leu Ala Glu Glu Ala Gly Thr Phe Phe Ala

165 170 175Ala Leu Thr Leu Gly Ser Arg Pro Leu Thr Ala Gln Val Asp Gly Ser

180 185 190His Ser Asp Thr Ile Glu Glu Ala Val Gln Leu Ala Val Asn Ala Ser

195 200 205Lys Arg Ala Asn Val Arg Ala Ile Leu Val Asp Gly Ser Ser Phe Ser

210 215 220Asn Gln Gly Ala Ser Asp Ala Gln Glu Ile Gly Leu Ser Ile Ala Ala225 230 235 240Gly Val Asp Tyr Val Arg Arg Leu Val Asp Ala Gly Leu Ser Thr Glu

245 250 255Ala Ala Leu Lys Gln Val Ala Phe Arg Phe Ala Val Thr Asp Glu Gln

260 265 270Phe Ala Gln Ile Ser Lys Leu Arg Val Ala Arg Arg Leu Trp Ala Arg

275 280 285Val Cys Glu Val Leu Gly Phe Pro Glu Leu Ala Val Ala Pro Gln His

290 295 300Ala Val Thr Ala Arg Ala Met Phe Ser Gln Arg Asp Pro Trp Val Asn305 310 315 320Met Leu Arg Ser Thr Val Ala Ala Phe Ala Ala Gly Val Gly Gly Ala

325 330 335Thr Asp Val Glu Val Arg Thr Phe Asp Asp Ala Ile Pro Asp Gly Val

340 345350Pro Gly Val Ser Arg Asn Phe Ala His Arg Ile Ala Arg Asn Thr Asn

355 360 365Leu Leu Leu Leu Glu Glu Ser His Leu Gly His Val Val Asp Pro Ala

370 375 380Gly Gly Ser Tyr Phe Val Glu Ser Phe Thr Asp Asp Leu Ala Glu Lys385 390 395 400Ala Trp Ala Val Phe Ser Gly Ile Glu Ala Glu Gly Gly Tyr Ser Ala

405 410 415Ala Cys Ala Ser Gly Thr Val Thr Ala Met Leu Asp Gln Thr Trp Glu

420 425 430Gln Thr Arg Ala Asp Val Ala Ser Arg Lys Lys Lys Leu Thr Gly Ile

435 440 445Asn Glu Phe Pro Asn Leu Ala Glu Ser Pro Leu Pro Ala Asp Arg Arg

450 455 460Val Glu Pro Ala Gly Val Arg Arg Trp Ala Ala Asp Phe Glu Ala Leu465 470 475 480Arg Asn Arg Ser Asp Ala Phe Leu Glu Lys Asn Gly Ala Arg Pro Gln

485 490 495Ile Thr Met Ile Pro Leu Gly Pro Leu Ser Lys His Asn Ile Arg Thr

500 505 510Gly Phe Thr Ser Asn Leu Leu Ala Ser Gly Gly Ile Glu Ala Ile Asn

515 520 525Pro Gly Gln Leu Val Pro Gly Thr Asp Ala Phe Ala Glu Ala Ala Gln

530 535 540Ala Ala Gly Ile Val Val Val Cys Gly Thr Asp Gln Glu Tyr Ala Glu545 550 555 560Thr Gly Glu Gly Ala Val Glu Lys Leu Arg Glu Ala Gly Val Glu Arg

565 570 575IleLeu Leu Ala Gly Ala Pro Lys Ser Phe Glu Gly Ser Ala His Ala

580 585 590Pro Asp Gly Tyr Leu Asn Met Thr Ile Asp Ala Ala Ala Thr Leu Ala

595 600 605Asp Leu Leu Asp Ala Leu Gly Ala

610615<210>185<211>1179<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1156)<223>RXS02106<400>185ggtcgccgct tttcgacgcc cgcctgcggc gggatgactg tgatggaggg gcgcgtcgac 60aagcaaaatc tctttagcaa attcggttac tgtggggcgc atg aat aac cat ttt 115

Met Asn Asn His Phe

1 5gag ctc aaa gta cct ggt gga aag ctt gtc gtc gtt gat gtg acc acc 163Glu Leu Lys Val Pro Gly Gly Lys Leu Val Val Val Asp Val Thr Thr

10 15 20gat ctg gat tcc att gct gac gtg aag att tcc ggc gat ttc ttc ctc 211Asp Leu Asp Ser Ile Ala Asp Val Lys Ile Ser Gly Asp Phe Phe Leu

25 30 35gaa ccc gat gag gca ttc ttc gcc ctt ggc cgg gcg ctg cag ggg gcg 259Glu Pro Asp Glu Ala Phe Phe Ala Leu Gly Arg Ala Leu Gln Gly Ala

40 45 50tcg gtg ggt gat aac act gat cgt ttg cag gca aag ttg gat gca gcg 307Ser Val Gly Asp Asn Thr Asp Arg Leu Gln Ala Lys Leu Asp Ala Ala

55 60 65ttg gcg gaa tat gat gac gtt gag cta cac ggc ttt agc act gcg gat 355Leu Ala Glu Tyr Asp Asp Val Glu Leu His Gly Phe Ser Thr Ala Asp 70 75 80 85att gct tta gct gtg cgt cgg gca gtc acc ggc gcg caa gat ttc acc403Ile Ala Leu Ala Val Arg Arg Ala Val Thr Gly Ala Gln Asp Phe Thr

90 95 100gat tat gaa tgg gaa atc ctg cac cca ggg gtg ctt cct acc cca ctt 451Asp Tyr Glu Trp Glu Ile Leu His Pro Gly Val Leu Pro Thr Pro Leu

105 110 115aac gtt gcg ttg gat gag ctc ctt ttg gac caa gtt gcc agt ggt cag 499Asn Val Ala Leu Asp Glu Leu Leu Leu Asp Gln Val Ala Ser Gly Gln

120 125 130cgt ggc ccg acg atg cgc att tgg gat tgg gat gat cgc gcc aca gtg 547Arg Gly Pro Thr Met Arg Ile Trp Asp Trp Asp Asp Arg Ala Thr Val

135 140 145atc ggt agt ttc cag tca tat gtc aat gaa atc aac caa gaa ggc gtt 595Ile Gly Ser Phe Gln Ser Tyr Val Asn Glu Ile Asn Gln Glu Gly Val150 155 160 165aat gaa cat ggt gtg acc gtg gta cga cgc atg tct ggt ggc ggt gca 643Asn Glu His Gly Val Thr Val Val Arg Arg Met Ser Gly Gly Gly Ala

170 175 180atg ttt atg gag ggc ggc aac tgc atc acc tat tcc ctg tat gca ccg 691Met Phe Met Glu Gly Gly Asn Cys Ile Thr Tyr Ser Leu Tyr Ala Pro

185 190 195gaa tct ctc gtt gct ggt ttg agc tat gag cag tcc tat gaa tat ttg 739Glu Ser Leu Val Ala Gly Leu Ser Tyr Glu Gln Ser Tyr Glu Tyr Leu

200 205 210gat cgt tgg gtg att gct gcg ctg aag aca cac gat gtt gac gct tgg 787Asp Arg Trp Val Ile Ala Ala Leu Lys Thr His Asp Val Asp Ala Trp

215 220 225tac gtg cct atc aat gac atc acc tcc acc ggc gga aaa atc ggt ggc 835Tyr Val Pro Ile Asn Asp Ile Thr Ser Thr Gly Gly Lys Ile Gly Gly230 235 240245gct gca cag aaa cgt cgc agt ggc gca gtc ctc cac cac gtg acc atg 883Ala Ala Gln Lys Arg Arg Ser Gly Ala Val Leu His His Val Thr Met

250 255 260tcc tat gac atc gat gcg gac atg atg acc cag gtg ttg cgc att gga 931Ser Tyr Asp Ile Asp Ala Asp Met Met Thr Gln Val Leu Arg Ile Gly

265 270 275aag gtg aag att tcc gac aag ggt ctt cgc agc gca aag aag cgc gtt 979Lys Val Lys Ile Ser Asp Lys Gly Leu Arg Ser Ala Lys Lys Arg Val

280 285 290gat cct ctg cgc cgc caa aca ggt gca tca cgt gag caa atc atc gac 1027Asp Pro Leu Arg Arg Gln Thr Gly Ala Ser Arg Glu Gln Ile Ile Asp

295 300 305acc cta aag tcc aca ttc agt gct agg tac ggc gcg caa gaa gta gag 1075Thr Leu Lys Ser Thr Phe Ser Ala Arg Tyr Gly Ala Gln Glu Val Glu310 315 320 325ctc agc gat gaa gat ttc gcg gca ggc cac gac cta gta aaa acc aaa 1123Leu Ser Asp Glu Asp Phe Ala Ala Gly His Asp Leu Val Lys Thr Lys

330 335 340tac gcc acc gag gag tgg act aag cga gtt caa tagtttctat ggatctgcac 1176Tyr Ala Thr Glu Glu Trp Thr Lys Arg Val Gln

345350 aag1179<210>186<211>352<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>186Met Asn Asn His Phe Glu Leu Lys Val Pro Gly Gly Lys Leu Val Val 151015 Val Asp Val Thr Thr Asp Leu Asp Ser Ile Ala Asp Val Lys Ile Ser

20 25 30Gly Asp Phe Phe Leu Glu Pro Asp Glu Ala Phe Phe Ala Leu Gly Arg

35 40 45Ala Leu Gln Gly Ala Ser Val Gly Asp Asn Thr Asp Arg Leu Gln Ala

50 55 60Lys Leu Asp Ala Ala Leu Ala Glu Tyr Asp Asp Val Glu Leu His Gly 65 70 75 80Phe Ser Thr Ala Asp Ile Ala Leu Ala Val Arg Arg Ala Val Thr Gly

85 90 95Ala Gln Asp Phe Thr Asp Tyr Glu Trp Glu Ile Leu His Pro Gly Val

100 105 110Leu Pro Thr Pro Leu Asn Val Ala Leu Asp Glu Leu Leu Leu Asp Gln

115 120 125Val Ala Ser Gly Gln Arg Gly Pro Thr Met Arg Ile Trp Asp Trp Asp

130 135 140Asp Arg Ala Thr Val Ile Gly Ser Phe Gln Ser Tyr Val Asn Glu Ile145 150 155 160Asn Gln Glu Gly Val Asn Glu His Gly Val Thr Val Val Arg Arg Met

165 170 175Ser Gly Gly Gly Ala Met Phe Met Glu Gly Gly Asn Cys Ile Thr Tyr

180 185 190Ser Leu Tyr Ala Pro Glu Ser Leu Val Ala Gly Leu Ser Tyr Glu Gln

195 200 205Ser Tyr Glu Tyr Leu Asp Arg Trp Val Ile Ala Ala Leu Lys Thr His

210 215 220Asp Val Asp Ala Trp Tyr Val Pro Ile Asn Asp Ile Thr Ser Thr Gly225 230 235 240Gly Lys Ile Gly Gly Ala Ala Gln Lys Arg Arg Ser Gly Ala Val Leu

245 250 255His His Val Thr Met Ser Tyr Asp Ile Asp Ala Asp Met Met Thr Gln

260 265 270Val Leu Arg Ile Gly Lys Val Lys Ile Ser Asp Lys Gly Leu Arg Ser

275 280 285Ala Lys Lys Arg Val Asp Pro Leu Arg Arg Gln Thr Gly Ala Ser Arg

290 295 300Glu Gln Ile Ile Asp Thr Leu Lys Ser Thr Phe Ser Ala Arg Tyr Gly305 310 315 320Ala Gln Glu Val Glu Leu Ser Asp Glu Asp Phe Ala Ala Gly His Asp

325 330 335Leu Val Lys Thr Lys Tyr Ala Thr Glu Glu Trp Thr Lys Arg Val Gln

340345350<210>187<211>876<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (853)<223>RXS01746<400>187aaaccgccac tcccctttca ctggggagtg gcggttttgt cgtttcatgc atgcagtgtg 60tgacttatca accttgttag ggctagggtg gatatctatc atg act gca cca aga 115

Met Thr Ala Pro Arg

1 5gat cct ttt ttc ccc gca gat ctt tct atc cgc gcg tct gca gag ccc 163Asp Pro Phe Phe Pro Ala Asp Leu Ser Ile Arg Ala Ser Ala Glu Pro

10 15 20att gaa att cag cgg ttg ggt ttg atc gat tat caa gag gcc tgg gat 211Ile Glu Ile Gln Arg Leu Gly Leu Ile Asp Tyr Gln Glu Ala Trp Asp

25 30 35tat caa gca gag ctt gct acc cgt agg gct aat gat gaa atc cct gat 259Tyr Gln Ala Glu Leu Ala Thr Arg Arg Ala Asn Asp Glu Ile Pro Asp

40 45 50cag ctg ctt att ttg gag cac ccg tcg gtg tat acc gca ggt aag cgc 307Gln Leu Leu Ile Leu Glu His Pro Ser Val Tyr Thr Ala Gly Lys Arg

55 60 65acc cag ccg gaa gat ctt ccc acc aac gga ctg ccg gtg atc aat gct 355Thr GlnPro Glu Asp Leu Pro Thr Asn Gly Leu Pro Val Ile Asn Ala 70 75 80 85gat cgt ggt ggt cgc atc acg tgg cat ggt cct ggc caa ttg gtg atc 403Asp Arg Gly Gly Arg Ile Thr Trp His Gly Pro Gly Gln Leu Val Ile

90 95 100tat ccg atc atc aaa tta gcc gat ccg atc gat gtg gtt gat tac gta 451Tyr Pro Ile Ile Lys Leu Ala Asp Pro Ile Asp Val Val Asp Tyr Val

105 110 115aga cgc ctc gag gaa gcg ctc atc caa gtt gtc ggc gat atg ggt gtt 499Arg Arg Leu Glu Glu Ala Leu Ile Gln Val Val Gly Asp Met Gly Val

120 125 130gcc ggc gct ggg cgc att gat ggg cgt tcg ggt gtg tgg gtg cca gct 547Ala Gly Ala Gly Arg Ile Asp Gly Arg Ser Gly Val Trp Val Pro Ala

135 140 145cat gat ggt tgg gtg gac agc aag gtt gcg gcc atc ggc att cga ata 595His Asp Gly Trp Val Asp Ser Lys Val Ala Ala Ile Gly Ile Arg Ile150 155 160 165act cgt ggt gtt gca atg cac ggt gtg gcc atc aac tgc aac aac acg 643Thr Arg Gly Val Ala Met His Gly Val Ala Ile Asn Cys Asn Asn Thr

170 175 180ttg gat ttc tat gag cac atc att ccg tgt ggc att gct gat gca ggc 691Leu Asp Phe Tyr Glu His Ile Ile Pro Cys Gly Ile Ala Asp Ala Gly

185 190 195ttg agc aca ctc tcg agg gaa ctg aaa agg gac gtt tca gtt gag gaa 739Leu Ser Thr Leu Ser Arg Glu Leu Lys Arg Asp Val Ser Val Glu Glu

200 205 210tta gtc gag cca tcg atc cgc gca ttg gat gat gct ttg gct ggt cgg 787Leu Val Glu Pro Ser Ile Arg Ala Leu Asp Asp Ala Leu Ala Gly Arg

215220 225ctg gtt gtt tct gat cat tct ttc ggc agc gcg ccc gac cca act aag 835Leu Val Val Ser Asp His Ser Phe Gly Ser Ala Pro Asp Pro Thr Lys230 235 240 245aat ctc cct aaa cgg ggg tagtacgagg aattttgtcg gtg 876Asn Leu Pro Lys Arg Gly

250<210>188<211>251<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>188Met Thr Ala Pro Arg Asp Pro Phe Phe Pro Ala Asp Leu Ser Ile Arg 151015 Ala Ser Ala Glu Pro Ile Glu Ile Gln Arg Leu Gly Leu Ile Asp Tyr

20 25 30Gln Glu Ala Trp Asp Tyr Gln Ala Glu Leu Ala Thr Arg Arg Ala Asn

35 40 45Asp Glu Ile Pro Asp Gln Leu Leu Ile Leu Glu His Pro Ser Val Tyr

50 55 60Thr Ala Gly Lys Arg Thr Gln Pro Glu Asp Leu Pro Thr Asn Gly Leu 65 70 75 80Pro Val Ile Asn Ala Asp Arg Gly Gly Arg Ile Thr Trp His Gly Pro

85 90 95Gly Gln Leu Val Ile Tyr Pro Ile Ile Lys Leu Ala Asp Pro Ile Asp

100 105 110Val Val Asp Tyr Val Arg Arg Leu Glu Glu Ala Leu Ile Gln Val Val

115 120 125Gly Asp Met Gly Val Ala Gly Ala Gly Arg Ile Asp Gly Arg Ser Gly

130 135 140Val Trp Val Pro Ala His Asp Gly Trp Val Asp Ser Lys Val Ala Ala145 150 155 160Ile Gly Ile Arg Ile Thr Arg Gly Val Ala Met His Gly Val Ala Ile

165 170 175Asn Cys Asn Asn Thr Leu Asp Phe Tyr Glu His Ile Ile Pro CysGly

180 185 190Ile Ala Asp Ala Gly Leu Ser Thr Leu Ser Arg Glu Leu Lys Arg Asp

195 200 205Val Ser Val Glu Glu Leu Val Glu Pro Ser Ile Arg Ala Leu Asp Asp

210 2l5 220Ala Leu Ala Gly Arg Leu Val Val Ser Asp His Ser Phe Gly Ser Ala225 230 235 240Pro Asp Pro Thr Lys Asn Leu Pro Lys Arg Gly

245250<210>189<211>1167<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1144)<223>RXS01747<400>189cgaagtagag ccgattgcag aatcggcgga atgagacgtc gaaaagcgtt taagctttcc 60ctaaaaatat cactaactcg aaagatgtaa ggttgcattt gtg act atc gca cct 115

Val Thr Ile Ala Pro

1 5gaa gga cga cga ctg cta cgc gtc gaa gct cga aac tca gaa acc ccg 163Glu Gly Arg Arg Leu Leu Arg Val Glu Ala Arg Asn Ser Glu Thr Pro

10 15 20att gag acg aag cct cga tgg att aga aac cag gtc aaa aac gga cct 211Ile Glu Thr Lys Pro Arg Trp Ile Arg Asn Gln Val Lys Asn Gly Pro

25 30 35gag tat cag gat atg aag gaa cgt gtc gct ggc gca tca cta cac act 259Glu Tyr Gln Asp Met Lys Glu Arg Val Ala Gly Ala Ser Leu His Thr

40 45 50gtg tgt cag gag gct ggc tgt cct aat atc cat gag tgt tgg gaa tcc 307Val Cys Gln Glu Ala Gly Cys Pro Asn Ile His Glu Cys Trp Glu Ser

55 60 65cgt gag gca acc ttc ctc att ggt ggc gcc aac tgc tct cgc cgc tgt 355Arg Glu Ala Thr Phe Leu Ile Gly Gly Ala Asn Cys Ser Arg Arg Cys 70 75 80 85gat ttc tgc atg atc aac tcg gct cgc cct gag cca ctc gac cgc ggt 403Asp Phe Cys Met Ile Asn Ser Ala Arg Pro Glu Pro Leu Asp Arg Gly

90 95 100gag cca ctg cgt gtc gct gag tct gtt cgt gag atg cag ctg aat tac 451Glu Pro Leu Arg Val Ala Glu Ser Val Arg Glu Met Gln Leu Asn Tyr

105 110 115tcc acc atc acc ggt gtt acc cgt gat gat ctg gat gat gaa ggc gca 499Ser Thr Ile Thr Gly Val Thr Arg Asp Asp Leu Asp Asp Glu Gly Ala

120 125 130tgg ctg tac tca gaa gtg gtt cgt aag atc cac gag ctg aac cca cac 547Trp Leu Tyr Ser Glu Val Val Arg Lys Ile His Glu Leu Asn Pro His

135 140 145acc ggt gtg gaa aac ctg gtg cct gat ttc tcc ggc aag aag gat ctg 595Thr Gly Val Glu Asn Leu Val Pro Asp Phe Ser Gly Lys Lys Asp Leu150 155 160 165ctg cag gaa gtt ttt gaa tcc cgc cca gag gtt ttc gct cac aac gtg 643Leu Gln Glu Val Phe Glu Ser Arg Pro Glu Val Phe Ala His Asn Val

170 175 180gaa act gtg cca cgt att ttc aag cgc att cgc cca gca ttc cgc tac 691Glu Thr Val Pro Arg Ile Phe Lys Arg Ile Arg Pro Ala Phe Arg Tyr

185 190 195gag cgt tca ctt gat gtg atc cgt cag gct cgc gat ttc ggt ctg gtg 739Glu Arg Ser Leu Asp Val Ile Arg Gln Ala Arg Asp Phe Gly Leu Val

200 205 210acc aag tcc aac ctg att ttg ggc atg ggt gaa acc aag gaa gaa atc 787Thr Lys Ser Asn Leu Ile Leu Gly Met Gly Glu Thr Lys Glu Glu Ile

215 220 225acc gag gcg ctg cag gat ctg cac gac gct ggc tgt gac atc atc acc 835Thr Glu Ala Leu Gln Asp Leu His Asp Ala Gly Cys Asp Ile Ile Thr230 235 240 245atc acc cag tac ctg cgt cct ggt cct ttg ttc cac ccc atc gag cgt 883Ile Thr Gln Tyr Leu Arg Pro Gly Pro Leu Phe His Pro Ile Glu Arg

250 255 260tgg gtg aag cct gag gag ttc ctc gag cac gct gat gct gca aag gaa 931Trp Val Lys Pro Glu Glu Phe Leu Glu His Ala Asp Ala Ala Lys Glu

265 270 275atg ggc ttc gct gct gtt atg tcc ggc cca ttg gtt cgt tcc tct tac 979Met Gly Phe Ala Ala Val Met Ser Gly Pro Leu Val Arg Ser Ser Tyr

280 285 290cgt gca ggc cgt ctg tac gcg cag gcc atg gag ttc cgt ggc gag gaa 1027Arg Ala Gly Arg Leu Tyr Ala Gln Ala Met Glu Phe Arg Gly Glu Glu

295 300 305atc cca gca cac ctc gcg cac ctg aag gat act tcc gga gga tcc acc 1075Ile Pro Ala His Leu Ala His Leu Lys Asp Thr Ser Gly Gly Ser Thr310 315 320 325gcc cag gaa gca tct aca ctt ctg gag cgt tac ggt gct tcc gaa gac 1123Ala Gln Glu Ala Ser Thr Leu Leu Glu Arg Tyr Gly Ala Ser Glu Asp

330 335 340acc cca gtg gtg tcc ttc aac taagcccgaa gttttttaac cgc 1167Thr Pro Val Val Ser Phe Asn

345<210>190<211>348<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>190Val Thr Ile Ala Pro Glu Gly Arg Arg Leu Leu Arg Val Glu Ala Arg 151015 Asn Ser Glu Thr Pro Ile Glu Thr Lys Pro Arg Trp Ile Arg Asn Gln

20 2530Val Lys Asn Gly Pro Glu Tyr Gln Asp Met Lys Glu Arg Val Ala Gly

35 40 45Ala Ser Leu His Thr Val Cys Gln Glu Ala Gly Cys Pro Asn Ile His

50 55 60Glu Cys Trp Glu Ser Arg Glu Ala Thr Phe Leu Ile Gly Gly Ala Asn 65 70 75 80Cys Ser Arg Arg Cys Asp Phe Cys Met Ile Asn Ser Ala Arg Pro Glu

85 90 95Pro Leu Asp Arg Gly Glu Pro Leu Arg Val Ala Glu Ser Val Arg Glu

100 105 110Met Gln Leu Asn Tyr Ser Thr Ile Thr Gly Val Thr Arg Asp Asp Leu

115 120 125Asp Asp Glu Gly Ala Trp Leu Tyr Ser Glu Val Val Arg Lys Ile His

130 135 140Glu Leu Asn Pro His Thr Gly Val Glu Asn Leu Val Pro Asp Phe Ser145 150 155 160Gly Lys Lys Asp Leu Leu Gln Glu Val Phe Glu Ser Arg Pro Glu Val

165 170 175Phe Ala His Asn Val Glu Thr Val Pro Arg Ile Phe Lys Arg Ile Arg

180 185 190Pro Ala Phe Arg Tyr Glu Arg Ser Leu Asp Val Ile Arg Gln Ala Arg

195 200 205Asp Phe Gly Leu Val Thr Lys Ser Asn Leu Ile Leu Gly Met Gly Glu

210 215 220Thr Lys Glu Glu Ile Thr Glu Ala Leu Gln Asp Leu His Asp Ala Gly225 230 235 240Cys Asp Ile Ile Thr Ile Thr Gln Tyr Leu Arg Pro Gly Pro Leu Phe

245 250255His Pro Ile Glu Arg Trp Val Lys Pro Glu Glu Phe Leu Glu His Ala

260 265 270Asp Ala Ala Lys Glu Met Gly Phe Ala Ala Val Met Ser Gly Pro Leu

275 280 285Val Arg Ser Ser Tyr Arg Ala Gly Arg Leu Tyr Ala Gln Ala Met Glu

290 295 300Phe Arg Gly Glu Glu Ile Pro Ala His Leu Ala His Leu Lys Asp Thr305 310 315 320Ser Gly Gly Ser Thr Ala Gln Glu Ala Ser Thr Leu Leu Glu Arg Tyr

325 330 335Gly Ala Ser Glu Asp Thr Pro Val Val Ser Phe Asn

340345<210>191<211>903<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (880)<223>RXC01748<400>191atcaccaaat gtggcggttt tgcgtcgaaa agcgtgctct ttctacacct ctttgaggtt 60cattttcgcg gtttcctcac aatcgcctat tgttaagtac atg gca gac gcg aaa 115

Met Ala Asp Ala Lys

1 5aag cag gcg gat aaa gcc gcc aag aag cag gta aga gca gcc aag aag 163Lys Gln Ala Asp Lys Ala Ala Lys Lys Gln Val Arg Ala Ala Lys Lys

10 15 20gca cag cgc aag gag act cgc tca caa atg tgg cag gtc ttc aac atg 211Ala Gln Arg Lys Glu Thr Arg Ser Gln Met Trp Gln Val Phe Asn Met

25 30 35caa cgc aag cag gat aag gct ctt att ccg ctt ctg ttg ctc gct att 259Gln Arg Lys Gln Asp Lys Ala Leu Ile Pro Leu Leu Leu Leu Ala Ile

40 45 50ctt ggt atc ccg ctg gtc ctt ttc ctc atc ggt ttg att tgg ggt ggt 307Leu Gly Ile Pro Leu Val Leu Phe Leu Ile Gly Leu Ile Trp Gly Gly

55 60 65cag tgg tgg atg ctt ccg atc ggc att gct gca ggt gtt gta gct gca 355Gln Trp Trp Met Leu Pro Ile Gly Ile Ala Ala Gly Val Val Ala Ala 70 75 80 85atg ttt att ttc acc cgt cgc gtt gag cgt gac gtg tac aag cgc gcc 403Met Phe Ile Phe Thr Arg Arg Val Glu Arg Asp Val Tyr Lys Arg Ala

90 95 100gaa ggt cag cag ggt gct gct ggt tgg gct gtg gag aac ctc cgc tct 451Glu Gly Gln Gln Gly Ala Ala Gly Trp Ala Val Glu Asn Leu Arg Ser

105 110 115ggc gtg ggc atg acc tgg cgc acc aag acc gct gtt gca gtg acc act 499Gly Val Gly Met Thr Trp Arg Thr Lys Thr Ala Val Ala Val Thr Thr

120 125 130cag atg gat gca gtg cac cgc gtc att ggt ctg tgt ggt gtt gtg ctg 547Gln Met Asp Ala Val His Arg Val Ile Gly Leu Cys Gly Val Val Leu

135 140 145gtc ggc gag ggc tcc cct cac cgc ctg aag cca atg ctt gcg cag caa 595Val Gly Glu Gly Ser Pro His Arg Leu Lys Pro Met Leu Ala Gln Gln150 155 160 165aag aag cgc ctg aac cgc gtg gca cct ggt gtt cca gtg tat gaa atc 643Lys Lys Arg Leu Asn Arg Val Ala Pro Gly Val Pro Val Tyr Glu Ile

170 175 180atc acg ggc aac ggc gaa ggc cag acc cct atc gcg aag ctg cag cgt 691Ile Thr Gly Asn Gly Glu Gly Gln Thr Pro Ile Ala Lys Leu Gln Arg

185 190 195gaa ctg gtc aag ctg cct cgc aac tac aag aag aac gac gtc gct gcc 739Glu Leu Val Lys Leu Pro Arg Asn Tyr Lys Lys Asn Asp Val Ala Ala

200 205 210ctg gcc gct cgc att gag gct atg gac aat gtc gga aac gct cct ggc 787Leu Ala Ala Arg Ile Glu Ala Met Asp Asn Val Gly Asn Ala Pro Gly

215 220 225gga tct ttg cct aag ggt cca ttg cca aag ggc gca agc atg tcc ggt 835Gly Ser Leu Pro Lys Gly Pro Leu Pro Lys Gly Ala Ser Met Ser Gly230 235 240 245atg aac cgc cgc gct cgc cga cag gct gaa cgc aag ggc gag gct 880Met Asn Arg Arg Ala Arg Arg Gln Ala Glu Arg Lys Gly Glu Ala

250255260 taaagccttt tcgctttcgc gtc 903<210>192<211>260<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>192Met Ala Asp Ala Lys Lys Gln Ala Asp Lys Ala Ala Lys Lys Gln Val 151015 Arg Ala Ala Lys Lys Ala Gln Arg Lys Glu Thr Arg Ser Gln Met Trp

20 25 30Gln Val Phe Asn Met Gln Arg Lys Gln Asp Lys Ala Leu Ile Pro Leu

35 40 45Leu Leu Leu Ala Ile Leu Gly Ile Pro Leu Val Leu Phe Leu Ile Gly

50 55 60Leu Ile Trp Gly Gly Gln Trp Trp Met Leu Pro Ile Gly Ile Ala Ala 65 70 75 80Gly Val Val Ala Ala Met Phe Ile Phe Thr Arg Arg Val Glu Arg Asp

85 90 95Val Tyr Lys Arg Ala Glu Gly Gln Gln Gly Ala Ala Gly Trp Ala Val

100 105 110Glu Asn Leu Arg Ser Gly Val Gly Met Thr Trp Arg Thr Lys Thr Ala

115 120 125Val Ala Val Thr Thr Gln Met Asp Ala Val His Arg Val Ile Gly Leu

130 135 140Cys Gly Val Val Leu Val Gly Glu Gly Ser Pro His Arg Leu Lys Pro145 150 155 160Met Leu Ala Gln Gln Lys Lys Arg Leu Asn Arg Val Ala Pro Gly Val

165 170 175Pro Val Tyr Glu Ile Ile Thr Gly Asn Gly Glu Gly Gln Thr Pro Ile

180 185 190Ala Lys Leu Gln Arg Glu Leu Val Lys Leu Pro Arg Asn Tyr Lys Lys

195 200 205Asn Asp Val Ala Ala Leu Ala Ala Arg Ile Glu Ala Met Asp Asn Val

210 215 220Gly Asn Ala Pro Gly Gly Ser Leu Pro Lys Gly Pro Leu Pro Lys Gly225 230 235 240Ala Ser Met Ser Gly Met Asn Arg Arg Ala Arg Arg Gln Ala Glu Arg

245 250 255Lys Gly Glu Ala

260<210>193<211>936<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (913)<223>RXC00354<400>193ggcttgtcgg taaggctgca gggtagcggg agtttccttc agattggaag ttctttaatt 60ttctcgatta tgtacctcat ttacgcgtaa agtttggggc atg gga aag tta ctt 115

Met Gly Lys Leu Leu

1 5ttc gta gac atc ggt ggc aca ctg ctg gat tac tca aat gaa gtt ccg 163Phe Val Asp Ile Gly Gly Thr Leu Leu Asp Tyr Ser Asn Glu Val Pro

10 15 20cgt tcg gcc gtt gac gcg atc cgt aag gca cgc gcc aaa gga cac cgc 211Arg Ser Ala Val Asp Ala Ile Arg Lys Ala Arg Ala Lys Gly His Arg

25 30 35gtg tac ttg agctct ggt cga agc agc gct gag gtg act tct cag ttg 259Val Tyr Leu Ser Ser Gly Arg Ser Ser Ala Glu Val Thr Ser Gln Leu

40 45 50tgg gat atc gga gtg gat ggc ctc att ggc gca aat ggt gga tat gtg 307Trp Asp Ile Gly Val Asp Gly Leu Ile Gly Ala Asn Gly Gly Tyr Val

55 60 65gaa agc gca cag gag tct gtg ttc cac cgc cgt ttg tcg ggt gag gag 355Glu Ser Ala Gln Glu Ser Val Phe His Arg Arg Leu Ser Gly Glu Glu 70 75 80 85acc cgc cac att gtg gag tgg ctc tac aac cgt ggt ttg gag ttt tat 403Thr Arg His Ile Val Glu Trp Leu Tyr Asn Arg Gly Leu Glu Phe Tyr

90 95 100ctc gag tcc aac aac ggt ttg tat gca agc cgt ggt ttc cgt gag gct 451Leu Glu Ser Asn Asn Gly Leu Tyr Ala Ser Arg Gly Phe Arg Glu Ala

105 110 115tct aag cca gtg ctg tct cgc ctt tcg gag aag acc gac gtg aca gtc 499Ser Lys Pro Val Leu Ser Arg Leu Ser Glu Lys Thr Asp Val Thr Val

120 125 130gat agc atg tac ccg gat atg ttc tgg ggc gcg agc ctt gat cgt gac 547Asp Ser Met Tyr Pro Asp Met Phe Trp Gly Ala Ser Leu Asp Arg Asp

135 140 145gat gtg aac aag atc agt tac atc ttc aat tct cag gaa gat ttg gac 595Asp Val Asn Lys Ile Ser Tyr Ile Phe Asn Ser Gln Glu Asp Leu Asp150 155 160 165gca gcg cgt gag gcg ttc cct aac ctg gag cac acc acg tgg ggt ggt 643Ala Ala Arg Glu Ala Phe Pro Asn Leu Glu His Thr Thr Trp Gly Gly

170 175 180cag acg ggt gcg ttg ttc ggc acg atc ggt gtg tct gtc aac aag aag 691Gln Thr Gly Ala Leu Phe Gly Thr Ile Gly Val Ser Val Asn Lys Lys

185 190 195atc ggc gtg gat cgc ctg ctg aag tac ctg aac gca gat cgc gca aac 739Ile Gly Val Asp Arg Leu Leu Lys Tyr Leu Asn Ala Asp Arg Ala Asn

200 205 210acc att gcg ttc ggc gac agc gat gag gat ctc tcc cta ttt gag gcg 787Thr Ile Ala Phe Gly Asp Ser Asp Glu Asp Leu Ser Leu Phe Glu Ala

215 220 225agc gct tac ggc gtc gcg atg ggc gag gcc acc gaa tcg ctc aag gct 835Ser Ala Tyr Gly Val Ala Met Gly Glu Ala Thr Glu Ser Leu Lys Ala230 235 240 245gct gct gac ctg gtc acg gat gct gtt ggg cag gac ggc ttg cgc aat 883Ala Ala Asp Leu Val Thr Asp Ala Val Gly Gln Asp Gly Leu Arg Asn

250 255 260gcg ttt tta aag ctt gag ctt atc gac gcc tgaccccatc aaagaacttc 933Ala Phe Leu Lys Leu Glu Leu Ile Asp Ala

265270 cca 936<210>194<211>271<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>194Met Gly Lys Leu Leu Phe Val Asp Ile Gly Gly Thr Leu Leu Asp Tyr 151015 Ser Asn Glu Val Pro Arg Ser Ala Val Asp Ala Ile Arg Lys Ala Arg

20 25 30Ala Lys Gly His Arg Val Tyr Leu Ser Ser Gly Arg Ser Ser Ala Glu

35 40 45Val Thr Ser Gln Leu Trp Asp Ile Gly Val Asp Gly Leu Ile Gly Ala

50 55 60Asn Gly Gly Tyr Val Glu Ser Ala Gln Glu Ser Val Phe His Arg Arg 65 70 75 80Leu Ser Gly Glu Glu Thr Arg His Ile Val Glu Trp Leu Tyr Asn Arg

85 90 95Gly Leu Glu Phe Tyr Leu Glu Ser Asn Asn Gly Leu Tyr Ala Ser Arg

100 105 110Gly Phe Arg Glu Ala Ser Lys Pro Val Leu Ser Arg Leu Ser Glu Lys

115 120 125Thr Asp Val Thr Val Asp Ser Met Tyr Pro Asp Met Phe Trp Gly Ala

130 135 140Ser Leu Asp Arg Asp Asp Val Asn Lys Ile Ser Tyr Ile Phe Asn Ser145 150 155 160Gln Glu Asp Leu Asp Ala Ala Arg Glu Ala Phe Pro Asn Leu Glu His

165 170 175Thr Thr Trp Gly Gly Gln Thr Gly Ala Leu Phe Gly Thr Ile Gly Val

180 185 190Ser Val Asn Lys Lys Ile Gly Val Asp Arg Leu Leu Lys Tyr Leu Asn

195 200 205Ala Asp Arg Ala Asn Thr Ile Ala Phe Gly Asp Ser Asp Glu Asp Leu

210 215 220Ser Leu Phe Glu Ala Ser Ala Tyr Gly Val Ala Met Gly Glu Ala Thr225 230 235 240Glu Ser Leu Lys Ala Ala Ala Asp Leu Val Thr Asp Ala Val Gly Gln

245 250 255Asp Gly Leu Arg Asn Ala Phe Leu Lys Leu Glu Leu Ile Asp Ala

260265270<210>195<211>1740<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1717)<223>RXC01749<400>195ggtttttgcg tgctctggtt tagggactgg ttttgggaac gtgcccagtt ccacatcaaa 60taacgctgag gtcgtactta atccatgaga tcatgaatgg gtg agc ttc ctt gta 115

Val Ser Phe Leu Val

15gaa aat caa tta ctc gcg ttg gtt gtc atc atg acg gtc gga cta ttg 163Glu Asn Gln Leu Leu Ala Leu Val Val Ile Met Thr Val Gly Leu Leu

10 15 20ctc ggc cgc atc aaa att ttc ggg ttc cgt ctc ggc gtc gcc gct gta 211Leu Gly Arg Ile Lys Ile Phe Gly Phe Arg Leu Gly Val Ala Ala Val

25 30 35ctg ttt gta ggt cta gcg cta tcc acc att gag ccg gat att tcc gtc 259Leu Phe Val Gly Leu Ala Leu Ser Thr Ile Glu Pro Asp Ile Ser Val

40 45 50cca tcc ctc att tac gtg gtt gga ctg tcg ctt ttt gtc tac acg atc 307Pro Ser Leu Ile Tyr Val Val Gly Leu Ser Leu Phe Val Tyr Thr Ile

55 60 65ggt ctg gaa gcc ggc cct gga ttc ttc acc tcc atg aaa acc act ggt 355Gly Leu Glu Ala Gly Pro Gly Phe Phe Thr Ser Met Lys Thr Thr Gly 70 75 80 85ctg cgc aac aac gca ctg acc ttg ggc gcc atc atc gcc acc acg gca 403Leu Arg Asn Asn Ala Leu Thr Leu Gly Ala Ile Ile Ala Thr Thr Ala

90 95 100ctc gca tgg gca ctc atc aca gtt ttg aac atc gat gcc gcc tcc ggc 451Leu Ala Trp Ala Leu Ile Thr Val Leu Asn Ile Asp Ala Ala Ser Gly

105 110 115gcc ggc atg ctc acc ggc gcg ctc acc aac acc cca gcc atg gcc gca 499Ala Gly Met Leu Thr Gly Ala Leu Thr Asn Thr Pro Ala Met Ala Ala

120 125 130gtt gtt gac gca ctt cct tcg ctt atc gac gac acc ggc cag ctt cac 547Val Val Asp Ala Leu Pro Ser Leu Ile Asp Asp Thr Gly Gln Leu His

135 140 145ctc atc gcc gag ctg ccc gtc gtc gca tat tcc ttg gca tac ccc ctc 595Leu Ile AlaGlu Leu Pro Val Val Ala Tyr Ser Leu Ala Tyr Pro Leu150 155 160 165ggt gtg ctc atc gtt att ctc tcc atc gcc atc ttc agc tct gtg ttc 643Gly Val Leu Ile Val Ile Leu Ser Ile Ala Ile Phe Ser Ser Val Phe

170 175 180aaa gtc gac cac aac aaa gaa gcc gaa gaa gcg ggc gtt gcg gtc cag 691Lys Val Asp His Asn Lys Glu Ala Glu Glu Ala Gly Val Ala Val Gln

185 190 195gaa ctc aaa ggc cgt cgc atc cgc gtc acc gtc gct gat ctt cca gcc 739Glu Leu Lys Gly Arg Arg Ile Arg Val Thr Val Ala Asp Leu Pro Ala

200 205 210ctg gag aac atc cca gag ctg ctc aac ctc cac gtc att gtg tcc cga 787Leu Glu Asn Ile Pro Glu Leu Leu Asn Leu His Val Ile Val Ser Arg

215 220 225gtg gaa cga gac ggt gag caa ttc atc ccg ctt tat ggc gaa cac gca 835Val Glu Arg Asp Gly Glu Gln Phe Ile Pro Leu Tyr Gly Glu His Ala230 235 240 245cgc atc ggc gat gtc tta aca gtg gtg ggt gcc gat gaa gaa ctc aac 883Arg Ile Gly Asp Val Leu Thr Val Val Gly Ala Asp Glu Glu Leu Asn

250 255 260cgc gcg gaa aaa gcc atc ggt gaa ctc att gac ggc gac ccc tac agc 931Arg Ala Glu Lys Ala Ile Gly Glu Leu Ile Asp Gly Asp Pro Tyr Ser

265 270 275aat gtg gaa ctt gat tac cga cgc atc ttc gtc tca aac aca gca gtc 979Asn Val Glu Leu Asp Tyr Arg Arg Ile Phe Val Ser Asn Thr Ala Val

280 285 290gtg ggc act ccc cta tcc aag ctc cag cca ctg ttt aaa gac atg ctg 1027Val Gly Thr Pro Leu Ser Lys Leu Gln Pro Leu Phe Lys Asp Met Leu

295300 305atc acc cgc atc agg cgc ggc gac aca gat ttg gtg gcc tcc tcc gac 1075Ile Thr Arg Ile Arg Arg Gly Asp Thr Asp Leu Val Ala Ser Ser Asp310 315 320 325atg act ttg cag ctc ggt gac cgt gtc cgc gtt gtc gca cca gca gaa 1123Met Thr Leu Gln Leu Gly Asp Arg Val Arg Val Val Ala Pro Ala Glu

330 335 340aaa ctc cgc gaa gca acc caa ttg ctc ggc gat tcc tac aag aaa ctc 1171Lys Leu Arg Glu Ala Thr Gln Leu Leu Gly Asp Ser Tyr Lys Lys Leu

345 350 355tcc gat ttc aac ctg ctc cca ctc gct gcc ggc ctc atg atc ggt gtg 1219Ser Asp Phe Asn Leu Leu Pro Leu Ala Ala Gly Leu Met Ile Gly Val

360 365 370ctt gtc ggc atg gtg gag ttc cca cta cca ggt gga agc tcc ctg aaa 1267Leu Val Gly Met Val Glu Phe Pro Leu Pro Gly Gly Ser Ser Leu Lys

375 380 385ctg ggt aac gca ggt gga ccg cta gtt gtt gcg ctg ctg ctc ggc atg 1315Leu Gly Asn Ala Gly Gly Pro Leu Val Val Ala Leu Leu Leu Gly Met390 395 400 405atc aat cgc aca ggc aag ttc gtc tgg caa atc ccc tac gga gca aac 1363Ile Asn Arg Thr Gly Lys Phe Val Trp Gln Ile Pro Tyr Gly Ala Asn

410 415 420ctt gcc ctt cgc caa ctg ggc atc aca cta ttt ttg gct gcc atc ggt 1411Leu Ala Leu Arg Gln Leu Gly Ile Thr Leu Phe Leu Ala Ala Ile Gly

425 430 435acc tca gcg ggc gca gga ttt cga tca gcg atc agc gac ccc caa tca 1459Thr Ser Ala Gly Ala Gly Phe Arg Ser Ala Ile Ser Asp Pro Gln Ser

440 445 450ctc acc atc atc ggc ttc ggt gcg ctg ctc act ttg ttc atc tcc atc 1507Leu Thr Ile Ile Gly PheGly Ala Leu Leu Thr Leu Phe Ile Ser Ile

455 460 465acg gtg ctg ttc gtt ggc cac aaa ctg atg aaa atc ccc ttc ggt gaa 1555Thr Val Leu Phe Val Gly His Lys Leu Met Lys Ile Pro Phe Gly Glu470 475 480 485acc gct ggc atc ctc gcc ggt acg caa acc cac cct gct gtg ctg agt 1603Thr Ala Gly Ile Leu Ala Gly Thr Gln Thr His Pro Ala Val Leu Ser

490 495 500tat gtg tca gat gcc tcc cgc aac gag ctc cct gcc atg ggt tat acc 1651Tyr Val Ser Asp Ala Ser Arg Asn Glu Leu Pro Ala Met Gly Tyr Thr

505 510 515tct gtg tat ccg ctg gcg atg atc gca aag atc ctg gcc gcc caa acg 1699Ser Val Tyr Pro Leu Ala Met Ile Ala Lys Ile Leu Ala Ala Gln Thr

520 525 530ttg ttg ttc cta ctt atc tagcattgac cccttaagcg cag 1740Leu Leu Phe Leu Leu Ile

535<210>196<211>539<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>196Val Ser Phe Leu Val Glu Asn Gln Leu Leu Ala Leu Val Val Ile Met 151015 Thr Val Gly Leu Leu Leu Gly Arg Ile Lys Ile Phe Gly Phe Arg Leu

20 25 30Gly Val Ala Ala Val Leu Phe Val Gly Leu Ala Leu Ser Thr Ile Glu

35 40 45Pro Asp Ile Ser Val Pro Ser Leu Ile Tyr Val Val Gly Leu Ser Leu

50 55 60Phe Val Tyr Thr Ile Gly Leu Glu Ala Gly Pro Gly Phe Phe Thr Ser 65 70 75 80Met Lys Thr Thr Gly Leu Arg Asn Asn Ala Leu Thr Leu Gly Ala Ile

85 9095Ile Ala Thr Thr Ala Leu Ala Trp Ala Leu Ile Thr Val Leu Asn Ile

100 105 110Asp Ala Ala Ser Gly Ala Gly Met Leu Thr Gly Ala Leu Thr Asn Thr

115 120 125Pro Ala Met Ala Ala Val Val Asp Ala Leu Pro Ser Leu Ile Asp Asp

130 135 140Thr Gly Gln Leu His Leu Ile Ala Glu Leu Pro Val Val Ala Tyr Ser145 150 155 160Leu Ala Tyr Pro Leu Gly Val Leu Ile Val Ile Leu Ser Ile Ala Ile

165 170 17Phe Ser Ser Val Phe Lys Val Asp His Asn Lys Glu Ala Glu Glu Ala

180 185 190Gly Val Ala Val Gln Glu Leu Lys Gly Arg Arg Ile Arg Val Thr Val

195 200 205Ala Asp Leu Pro Ala Leu Glu Asn Ile Pro Glu Leu Leu Asn Leu His

210 215 220Val Ile Val Ser Arg Val Glu Arg Asp Gly Glu Gln Phe Ile Pro Leu225 230 235 240Tyr Gly Glu His Ala Arg Ile Gly Asp Val Leu Thr Val Val Gly Ala

245 250 255Asp Glu Glu Leu Asn Arg Ala Glu Lys Ala Ile Gly Glu Leu Ile Asp

260 265 270Gly Asp Pro Tyr Ser Asn Val Glu Leu Asp Tyr Arg Arg Ile Phe Val

275 280 285Ser Asn Thr Ala Val Val Gly Thr Pro Leu Ser Lys Leu Gln Pro Leu

290 295 300Phe Lys Asp Met Leu Ile Thr Arg Ile Arg Arg Gly Asp Thr Asp Leu305 310 315 320Val Ala SerSer Asp Met Thr Leu Gln Leu Gly Asp Arg Val Arg Val

325 330 335Val Ala Pro Ala Glu Lys Leu Arg Glu Ala Thr Gln Leu Leu Gly Asp

340 345 350Ser Tyr Lys Lys Leu Ser Asp Phe Asn Leu Leu Pro Leu Ala Ala Gly

355 360 365Leu Met Ile Gly Val Leu Val Gly Met Val Glu Phe Pro Leu Pro Gly

370 375 380Gly Ser Ser Leu Lys Leu Gly Asn Ala Gly Gly Pro Leu Val Val Ala385 390 395 400Leu Leu Leu Gly Met Ile Asn Arg Thr Gly Lys Phe Val Trp Gln Ile

405 410 415Pro Tyr Gly Ala Asn Leu Ala Leu Arg Gln Leu Gly Ile Thr Leu Phe

420 425 430Leu Ala Ala Ile Gly Thr Ser Ala Gly Ala Gly Phe Arg Ser Ala Ile

435 440 445Ser Asp Pro Gln Ser Leu Thr Ile Ile Gly Phe Gly Ala Leu Leu Thr

450 455 460Leu Phe Ile Ser Ile Thr Val Leu Phe Val Gly His Lys Leu Met Lys465 470 475 480Ile Pro Phe Gly Glu Thr Ala Gly Ile Leu Ala Gly Thr Gln Thr His

485 490 495Pro Ala Val Leu Ser Tyr Val Ser Asp Ala Ser Arg Asn Glu Leu Pro

500 505 510Ala Met Gly Tyr Thr Ser Val Tyr Pro Leu Ala Met Ile Ala Lys Ile

515 520 525Leu Ala Ala Gln Thr Leu Leu Phe Leu Leu Ile

530535<210>197<211>1023<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1000)<223>RXA02268<400>197tgaatcgttg gtgcttcgag ttgggattgt tatgtgggga gacgtcgata agcaaaacac 60ttgccgagcg caagccggcc tacggcgcta gtgtgagcac atg tcc cag gaa aat 115

Met Ser Gln Glu Asn

1 5tct ggt ttg ttc aag cgc gcg att aca cgt ggg gtg gct aag gtg cgc 163Ser Gly Leu Phe Lys Arg Ala Ile Thr Arg Gly Val Ala Lys Val Arg

10 15 20cgg aat ccg cgc gag gat ttt gcg gag gaa ttc acc caa gaa ctc tac 211Arg Asn Pro Arg Glu Asp Phe Ala Glu Glu Phe Thr Gln Glu Leu Tyr

25 30 35gat cac gca aca aat atc acc ctg ccc ctg acg gcg cgg ctg aag ccg 259Asp His Ala Thr Asn Ile Thr Leu Pro Leu Thr Ala Arg Leu Lys Pro

40 45 50aat ggg ttt ttc cag gat gat tgg cgg gcg cga cca agt ggt gcg cga 307Asn Gly Phe Phe Gln Asp Asp Trp Arg Ala Arg Pro Ser Gly Ala Arg

55 60 65ccg tgg ccg atc gtg cta att cac gga tcc ggg gcc agc aag ggt tca 355Pro Trp Pro Ile Val Leu Ile His Gly Ser Gly Ala Ser Lys Gly Ser 70 75 80 85tgg gag gaa atg ggc gct gag ctg cgc agc aaa ggt tgg gcc gtg ttt 403Trp Glu Glu Met Gly Ala Glu Leu Arg Ser Lys Gly Trp Ala Val Phe

90 95 100gcc cct gac ttt gga acg cgt gcc acc gag cca att gcg gcg tcg gct 451Ala Pro Asp Phe Gly Thr Arg Ala Thr Glu Pro Ile Ala Ala Ser Ala

105 110 115gcc caa att ggt gcg tat att gat gcc gtt ttg ttg gtg acg ggc gct 499Ala Gln Ile Gly Ala Tyr Ile Asp Ala Val Leu Leu Val Thr Gly Ala

120 125 130gcg cag att gtg ctg gtt ggg cat tcg caa ggc ggt gtc gtg gcg cgg 547Ala Gln Ile Val Leu Val Gly His Ser Gln Gly Gly Val Val Ala Arg

135 140 145tat tgg atg cgc acc tac ggc gga tac atg aag gtc agg cac atg att 595Tyr Trp Met Arg Thr Tyr Gly Gly Tyr Met Lys Val Arg His Met Ile150 155 160 165tcc atc tct acg cca aat cac gga acg ctc atg gga ggc att tta aac 643Ser Ile Ser Thr Pro Asn His Gly Thr Leu Met Gly Gly Ile Leu Asn

170 175 180ccg atg acg aag gtg aaa tcg gga gag gga acg atc gaa aag ctg atg 691Pro Met Thr Lys Val Lys Ser Gly Glu Gly Thr Ile Glu Lys Leu Met

185 190 195cac aga cta ttc ggg ccc act ggt ttt gaa cag ctg cgc gga cac gac 739His Arg Leu Phe Gly Pro Thr Gly Phe Glu Gln Leu Arg Gly His Asp

200 205 210atc atc gag ttt ttg gcc gac ggt ggg gac ctc gat cca ggc gtc acc 787Ile Ile Glu Phe Leu Ala Asp Gly Gly Asp Leu Asp Pro Gly Val Thr

215 220 225tac acc tgc att ggt acc cat ttt gat cct ttc atc caa cct ccg gag 835Tyr Thr Cys Ile Gly Thr His Phe Asp Pro Phe Ile Gln Pro Pro Glu230 235 240 245gtg gcc ttt ttg gag gtc aac gag gac gat gat cca aat cga gtc cac 883Val Ala Phe Leu Glu Val Asn Glu Asp Asp Asp Pro Asn Arg Val His

250 255 260aat att tgg gtc gaa gat gaa cac ccg cgc gca atg att gcc cac aac 931Asn Ile Trp Val Glu Asp Glu His Pro Arg Ala Met Ile Ala His Asn

265270 275gat atg gtg cgc gat ccc agg gtg atc gaa atc gta cgc gca gag ctc 979Asp Met Val Arg Asp Pro Arg Val Ile Glu Ile Val Arg Ala Glu Leu

280 285 290gac cgg gtg gca cgc ctc ggc taagttgggg acatggttga cgc 1023Asp Arg Val Ala Arg Leu Gly

295300<210>198<211>300<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>198Met Ser Gln Glu Asn Ser Gly Leu Phe Lys Arg Ala Ile Thr Arg Gly 151015 Val Ala Lys Val Arg Arg Asn Pro Arg Glu Asp Phe Ala Glu Glu Phe

20 25 30Thr Gln Glu Leu Tyr Asp His Ala Thr Asn Ile Thr Leu Pro Leu Thr

35 40 45Ala Arg Leu Lys Pro Asn Gly Phe Phe Gln Asp Asp Trp Arg Ala Arg

50 55 60Pro Ser Gly Ala Arg Pro Trp Pro Ile Val Leu Ile His Gly Ser Gly 65 70 75 80Ala Ser Lys Gly Ser Trp Glu Glu Met Gly Ala Glu Leu Arg Ser Lys

85 90 95Gly Trp Ala Val Phe Ala Pro Asp Phe Gly Thr Arg Ala Thr Glu Pro

100 105 110Ile Ala Ala Ser Ala Ala Gln Ile Gly Ala Tyr Ile Asp Ala Val Leu

115 120 125Leu Val Thr Gly Ala Ala Gln Ile Val Leu Val Gly His Ser Gln Gly

130 135 140Gly Val Val Ala Arg Tyr Trp Met Arg Thr Tyr Gly Gly Tyr Met Lys145 150 155 160Val Arg His Met Ile Ser Ile Ser Thr Pro Asn His Gly Thr Leu Met

165 170 175GlyGly Ile Leu Asn Pro Met Thr Lys Val Lys Ser Gly Glu Gly Thr

180 185 190Ile Glu Lys Leu Met His Arg Leu Phe Gly Pro Thr Gly Phe Glu Gln

195 200 205Leu Arg Gly His Asp Ile Ile Glu Phe Leu Ala Asp Gly Gly Asp Leu

210 215 220Asp Pro Gly Val Thr Tyr Thr Cys Ile Gly Thr His Phe Asp Pro Phe225 230 235 240Ile Gln Pro Pro Glu Val Ala Phe Leu Glu Val Asn Glu Asp Asp Asp

245 250 255Pro Asn Arg Val His Asn Ile Trp Val Glu Asp Glu His Pro Arg Ala

260 265 270Met Ile Ala His Asn Asp Met Val Arg Asp Pro Arg Val Ile Glu Ile

275 280 285Val Arg Ala Glu Leu Asp Arg Val Ala Arg Leu Gly

290295300<210>199<211>1095<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1072)<223>RXA02269<400>199cgcaatgatt gcccacaacg atatggtgcg cgatcccagg gtgatcgaaa tcgtacgcgc 60agagctcgac cgggtggcac gcctcggcta agttggggac atg gtt gac gcc ctc 115

Met Val Asp Ala Leu

1 5aat gat ctc cgc cga gaa ctc aca aac gcg tta agg tcc gtg tgg aaa 163Asn Asp Leu Arg Arg Glu Leu Thr Asn Ala Leu Arg Ser Val Trp Lys

10 15 20aac ctc ccc act gat aac gcc ccg cag gcc gat gcc ttg cca gac gat 211Asn Leu Pro Thr Asp Asn Ala Pro Gln Ala Asp Ala Leu Pro Asp Asp

25 30 35gta gtg gaa gag att gcg ata aat ttc tac cgt gat ccc aaa aac cgc 259Val Val Glu Glu Ile Ala Ile Asn Phe Tyr Arg Asp Pro Lys Asn Arg

40 45 50ggc aaa ctc aac gaa gac aaa aca gat tcc ttg ccg atg ctc gcg cgc 307Gly Lys Leu Asn Glu Asp Lys Thr Asp Ser Leu Pro Met Leu Ala Arg

55 60 65ata cgt tca cgt gga ctt ttt gaa gac gat tgg cgc gcc cgc ccc acc 355Ile Arg Ser Arg Gly Leu Phe Glu Asp Asp Trp Arg Ala Arg Pro Thr 70 75 80 85gaa gac cgc ccc tgg cca gtg gta tta gtc cac gga act gga tca aca 403Glu Asp Arg Pro Trp Pro Val Val Leu Val His Gly Thr Gly Ser Thr

90 95 100aaa ggt gat tgg caa gac ttg gga gcc gat cta cgc cgc gac ggc tgg 451Lys Gly Asp Trp Gln Asp Leu Gly Ala Asp Leu Arg Arg Asp Gly Trp

105 110 115gca gtg ttt gca ccc gaa ttt ggc caa cgc gcc acc ggt tca gtc gca 499Ala Val Phe Ala Pro Glu Phe Gly Gln Arg Ala Thr Gly Ser Val Ala

120 125 130gaa tca tcc gca caa att ggc gcc tat ata gat aca gta ttg ctt gct 547Glu Ser Ser Ala Gln Ile Gly Ala Tyr Ile Asp Thr Val Leu Leu Ala

135 140 145aca gga gcc tca aaa gtc att gtc gtt ggc cac tcc caa ggc ggc gtg 595Thr Gly Ala Ser Lys Val Ile Val Val Gly His Ser Gln Gly Gly Val150 155 160 165ttg ctg aga tac tgg atg cgt gtt ttg ggt ggt gca tcc aaa gtc aaa 643Leu Leu Arg Tyr Trp Met Arg Val Leu Gly Gly Ala Ser Lys Val Lys

170 175 180cac atg gtc tcc ctc gct gtc ccc aat cac ggc acc acc atg ggc gga 691His Met Val Ser Leu Ala Val Pro Asn His Gly Thr Thr Met Gly Gly

185 190 195atc gtc agc ccg cta atc cgt asc aat cgt ggc gaa agt gtg gtt aat 739Ile Val Ser Pro Leu Ile Arg Asn Asn Arg Gly Glu Ser Val Val Asn

200 205 210tct gtc gtt caa tca tgg ttc ggc gaa gct gga ttt gaa atg atc cgc 787Ser Val Val Gln Ser Trp Phe Gly Glu Ala Gly Phe Glu Met Ile Arg

215 220 225gga cac gac acc atc aac gcc atc aat gaa ggc ggc gat ttg gat cca 835Gly His Asp Thr Ile Asn Ala Ile Asn Glu Gly Gly Asp Leu Asp Pro230 235 240 245gac gtg aca tat ctg tgc atc gcc acc cac ttt gac acc gtg att cag 883Asp Val Thr Tyr Leu Cys Ile Ala Thr His Phe Asp Thr Val Ile Gln

250 255 260ccc cct gaa acc tgc ttc cta gag gcc cgg aac ccc gaa gaa ctc aag 931Pro Pro Glu Thr Cys Phe Leu Glu Ala Arg Asn Pro Glu Glu Leu Lys

265 270 275cgg gtc caa aac atc tgg gtg gaa aac ctc gac ccc aat tca gtc gtg 979Arg Val Gln Asn Ile Trp Val Glu Asn Leu Asp Pro Asn Ser Val Val

280 285 290ctc cac gaa gca atg cct tac gat ccc cgc gta cgc gca ctg gtc agg 1027Leu His Glu Ala Met Pro Tyr Asp Pro Arg Val Arg Ala Leu Val Arg

295300305 gcg gat ttg agc aaa ttg gtg gag att tcc gag act gcg gag aac 1072Ala Asp Leu Ser Lys Leu Val Glu Ile Ser Glu Thr Ala Glu Asn 310315320 tagggtttt ggtggttgtc taa 1095<210>200<211>324<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>200Met Val Asp Ala Leu Asn Asp Leu Arg Arg Glu Leu Thr Asn Ala Leu 151015 Arg Ser Val Trp Lys Asn Leu Pro Thr Asp Asn Ala Pro Gln Ala Asp

20 25 30Ala Leu Pro Asp Asp Val Val Glu Glu Ile Ala Ile Asn Phe Tyr Arg

35 40 45Asp Pro Lys Asn Arg Gly Lys Leu Asn Glu Asp Lys Thr Asp Ser Leu

50 55 60Pro Met Leu Ala Arg Ile Arg Ser Arg Gly Leu Phe Glu Asp Asp Trp 65 70 75 80Arg Ala Arg Pro Thr Glu Asp Arg Pro Trp Pro Val Val Leu Val His

85 90 95Gly Thr Gly Ser Thr Lys Gly Asp Trp Gln Asp Leu Gly Ala Asp Leu

100 105 110Arg Arg Asp Gly Trp Ala Val Phe Ala Pro Glu Phe Gly Gln Arg Ala

115 120 125Thr Gly Ser Val Ala Glu Ser Ser Ala Gln Ile Gly Ala Tyr Ile Asp

130 135 140Thr Val Leu Leu Ala Thr Gly Ala Ser Lys Val Ile Val Val Gly His145 150 155 160Ser Gln Gly Gly Val Leu Leu Arg Tyr Trp Met Arg Val Leu Gly Gly

165 170 175Ala Ser Lys Val Lys His Met Val Ser Leu Ala Val Pro Asn His Gly

180 185 190Thr Thr Met Gly Gly Ile Val Ser Pro Leu Ile Arg Asn Asn Arg Gly

195 200 205Glu Ser Val Val Asn Ser Val Val Gln Ser Trp Phe Gly Glu Ala Gly

210 215 220Phe Glu Met Ile Arg Gly His Asp Thr Ile Asn Ala Ile Asn Glu Gly225 230 235 240Gly Asp Leu Asp Pro Asp Val Thr Tyr Leu Cys Ile Ala Thr His Phe

245 250 255Asp Thr Val Ile Gln Pro Pro Glu Thr Cys Phe Leu Glu Ala Arg Asn

260 265 270Pro Glu Glu Leu Lys Arg Val Gln Asn Ile Trp Val Glu Asn Leu Asp

275 280 285Pro Asn Ser Val Val Leu His Glu Ala Met Pro Tyr Asp Pro Arg Val

290295300 Arg Ala Leu Val Arg Ala Asp Leu Ser Lys Leu Val Glu Ile Ser Glu 3053103 l 5320 Thr Ala Glu Asn<210>201<211>1146<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).&lt 3)<223>RXA01614<400>201tgcaattcgc aaacatgagt agtatcgcgg aagtttcacc acgtgaacat ttcagtcgac 60tcgcgcacac cacaccaaca atcgacctat cgttatacgt atg aat cag atg cag 115

Met Asn Gln Met Gln

1 5cag tgg aaa cca gac ttc ctg gga gag ggc tac caa aac ctc acc atc 163Gln Trp Lys Pro Asp Phe Leu Gly Glu Gly Tyr Gln Asn Leu Thr Ile

10 15 20gag ctc ggc gac gac ccg gat aat gaa aca gat gtt gtg aca acg gtt 211Glu Leu Gly Asp Asp Pro Asp Asn Glu Thr Asp Val Val Thr Thr Val

25 30 35gtg cgc tac aac cca gac aat cac gcg gac gag tct ttt gct gcc cgc 259Val Arg Tyr Asn Pro Asp Asn His Ala Asp Glu Ser Phe Ala Ala Arg

40 45 50cca gcg ttg ctg tgg gtt cac ggc atg acg gac tac ttc ttc cac act 307Pro Ala Leu Leu Trp Val His Gly Met Thr Asp Tyr Phe Phe His Thr

55 60 65gaa ttc gcg gag ttt ttc cac aat gcc ggt ttt gct gtg tac ggc att 355Glu Phe Ala Glu Phe Phe His Asn Ala Gly Phe Ala Val Tyr Gly Ile 70 75 80 85gat ctt aga aaa tgt gga cgc tcc tac cgt cca gga cag cag tgg cac 403Asp Leu Arg Lys Cys Gly Arg Ser Tyr Arg Pro Gly Gln Gln Trp His

90 95 100tac acc tct gat ctt gcc cat tac ttc cct gac tta aca gct gct gcc 451Tyr Thr Ser Asp Leu Ala His Tyr Phe Pro Asp Leu Thr Ala Ala Ala

105 110 115gag gtc atc tct tcc acc cac cct gag cta gtc ccc gtc gcc cat tcc 499Glu Val Ile Ser Ser Thr His Pro Glu Leu Val Pro Val Ala His Ser

120 125 130act ggt gga ctc atc gtt cct ctg tgg atg tcc cag atg cgc aca agc 547Thr Gly Gly Leu Ile Val Pro Leu Trp Met Ser Gln Met Arg Thr Ser

135 140 145aat cca gct gcc att gag aag att cca gcg ctg gtc ctc aac agt ccg 595Asn Pro Ala Ala Ile Glu Lys Ile Pro Ala Leu Val Leu Asn Ser Pro150 155 160 165tgg ctg gac atg atg tat cca cca ctg ttc atc aag ctg atc acc cct 643Trp Leu Asp Met Met Tyr Pro Pro Leu Phe Ile Lys Leu Ile Thr Pro

170 175 180atg gtg agg gtg ttg ggc aaa cgc tcc ccc aca acc atc atc cca ggc 691Met Val Arg Val Leu Gly Lys Arg Ser Pro Thr Thr Ile Ile Pro Gly

185 190 195gga ggt ttg gga gca tac gga aaa tcg atc cat aag aac ttt tac ggc 739Gly Gly Leu Gly Ala Tyr Gly Lys Ser Ile His Lys Asn Phe Tyr Gly

200 205 210gaa tgg gac ttt gac acc acc atc aag cct gta gaa gga cat aaa aag 787Glu Trp Asp Phe Asp Thr Thr Ile Lys Pro Val Glu Gly His Lys Lys

215220 225agc atc gga tgg ctt cgg gca gtc atg gct ggc caa gca gaa atc cat 835Ser Ile Gly Trp Leu Arg Ala Val Met Ala Gly Gln Ala Glu Ile His230 235 240 245cac gac cac gtg aat gtc gga gtg gac gtg ctc acg ctg tgt tca aat 883His Asp His Val Asn Val Gly Val Asp Val Leu Thr Leu Cys Ser Asn

250 255 260aag tcc tgg ttg aag tct gaa tac aca gag gac acc aac act tca gac 931Lys Ser Trp Leu Lys Ser Glu Tyr Thr Glu Asp Thr Asn Thr Ser Asp

265 270 275gcg gtt ttg gat gtg aaa cac att caa aag tgg gct cct cat ttg agc 979Ala Val Leu Asp Val Lys His Ile Gln Lys Trp Ala Pro His Leu Ser

280 285 290tcg cca tcg tcc agg gtt gat gtt gag atc atc gac aac gct cgc cac 1027Ser Pro Ser Ser Arg Val Asp Val Glu Ile Ile Asp Asn Ala Arg His

295 300 305gat att ttc ctc tca agg aaa ccc gcc aga gat cac gcc tct gaa gta 1075Asp Ile Phe Leu Ser Arg Lys Pro Ala Arg Asp His Ala Ser Glu Val310 315 320 325ctc aac aac tgg ctg caa tcg aag ctt tcc agc ctc aaa cca tct caa 1123Leu Asn Asn Trp Leu Gln Ser Lys Leu Ser Ser Leu Lys Pro Ser Gln

330335340 taacaccgcg aat tatagac tga 1146<210>202<211>341<212>PRT213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>202Met Asn Gln Met Gln Gln Trp Lys Pro Asp Phe Leu Gly Glu Gly Tyr 151015 Gln Asn Leu Thr Ile Glu Leu Gly Asp Asp Pro Asp Asn Glu Thr Asp

20 25 30Val Val Thr Thr Val Val Arg Tyr Asn Pro Asp Asn His Ala Asp Glu

35 40 45Ser Phe Ala Ala Arg Pro Ala Leu Leu Trp Val His Gly Met Thr Asp

50 55 60Tyr Phe Phe His Thr Glu Phe Ala Glu Phe Phe His Asn Ala Gly Phe 65 70 75 80Ala Val Tyr Gly Ile Asp Leu Arg Lys Cys Gly Arg Ser Tyr Arg Pro

85 90 95Gly Gln Gln Trp His Tyr Thr Ser Asp Leu Ala His Tyr Phe Pro Asp

100 105 110Leu Thr Ala Ala Ala Glu Val Ile Ser Ser Thr His Pro Glu Leu Val

115 120 125Pro Val Ala His Ser Thr Gly Gly Leu Ile Val Pro Leu Trp Met Ser

130 135 140Gln Met Arg Thr Ser Asn Pro Ala Ala Ile Glu Lys Ile Pro Ala Leu145 150 155 160Val Leu Asn Ser Pro Trp Leu Asp Met Met Tyr Pro Pro Leu Phe Ile

165 170 175Lys Leu Ile Thr Pro Met Val Arg Val Leu Gly Lys Arg Ser Pro Thr

180 185 190Thr Ile Ile Pro Gly Gly Gly Leu Gly Ala Tyr Gly Lys Ser Ile His

195 200 205Lys Asn Phe Tyr Gly Glu Trp Asp Phe Asp Thr Thr Ile Lys Pro Val

210 215 220Glu Gly His Lys Lys Ser Ile Gly Trp Leu Arg Ala Val Met Ala Gly225 230 235 240Gln Ala Glu Ile His His Asp His Val Asn Val Gly Val Asp Val Leu

245 250 255Thr Leu Cys Ser Asn Lys Ser Trp Leu Lys Ser Glu Tyr Thr Glu Asp

260 265 270Thr Asn Thr Ser Asp Ala Val Leu Asp Val Lys His Ile Gln Lys Trp

275 280 285Ala Pro His Leu Ser Ser Pro Ser Ser Arg Val Asp Val Glu Ile Ile

290 295 300Asp Asn Ala Arg His Asp Ile Phe Leu Ser Arg Lys Pro Ala Arg Asp305 310 315 320His Ala Ser Glu Val Leu Asn Asn Trp Leu Gln Ser Lys Leu Ser Ser

325 330 335Leu Lys Pro Ser Gln

340<210>203<211>630<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (607)<223>RXA01983<400>203atatcgctgc catggcagcc ttgctgggca acctcaagca cactgaccta gaagagctcc 60ccaccgatta ccaggggtgt cctcccatgt ccgctgcgtt atg gaa ggc tac gga 115

Met Glu Gly Tyr Gly

1 5cct acc cag atc gaa aag ctc tta cct gca tac aca cag gtc aac aca 163Pro Thr Gln Ile Glu Lys Leu Leu Pro Ala Tyr Thr Gln Val Asn Thr

10 15 20gcc ggg aat aat cca gcg acg acg cct gag caa gat ctc ctc ggc gga 211Ala Gly Asn Asn Pro Ala Thr Thr Pro Glu Gln Asp Leu Leu Gly Gly

25 30 35gct gca acc tcg ccg gaa aac tac gac cac cag ctg cag tac gca gtc 259Ala Ala Thr Ser Pro Glu Asn Tyr Asp His Gln Leu Gln Tyr Ala Val

40 45 50gac gcc agt ccg gtg cat cag aat gcg gca cag gca ccg ccc ttc ctg 307Asp Ala Ser Pro Val His Gln Asn Ala Ala Gln Ala Pro Pro Phe Leu

55 60 65atc atg cac ggc act ggt gac cgg atg gtc cct ccg gag caa tcg gct355Ile Met His Gly Thr Gly Asp Arg Met Val Pro Pro Glu Gln Ser Ala 70 75 80 85gcg ctg cac acc cat ctt gtg cag gct ggt cgg cag tcc acc ctg gta 403Ala Leu His Thr His Leu Val Gln Ala Gly Arg Gln Ser Thr Leu Val

90 95 100ctc att gag ggc ttt ggc cac ggt ttc ctc aat ccc ggg gaa gtc gcg 451Leu Ile Glu Gly Phe Gly His Gly Phe Leu Asn Pro Gly Glu Val Ala

105 110 115gag ctg ggg cca aac gtt cga cta gac aat ggt cgg ctc gag cgg gag 499Glu Leu Gly Pro Asn Val Arg Leu Asp Asn Gly Arg Leu Glu Arg Glu

120 125 130cct cag aca aat ttc agc gcg cag cag agt ccg gga aac ccc ttt gaa 547Pro Gln Thr Asn Phe Ser Ala Gln Gln Ser Pro Gly Asn Pro Phe Glu

135140145 cta cag gga ctt gcc gcc gac cat gag atg atc aag cgc ttt ttc acc 595Leu Gln Gly Leu Ala Ala Asp His Glu Met Ile Lys Arg Phe Phe Thr 150155160165 ctg cac ctt cgc taagactcta ccttcaccca act 630Leu His Leu Arg<210>204<211>169<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>204Met Glu Gly Tyr Gly Pro Thr Gln Ile Glu Lys Leu Leu Pro Ala Tyr 151015 Thr Gln Val Asn Thr Ala Gly Asn Asn Pro Ala Thr Thr Pro Glu Gln

20 25 30Asp Leu Leu Gly Gly Ala Ala Thr Ser Pro Glu Asn Tyr Asp His Gln

35 40 45Leu Gln Tyr Ala Val Asp Ala Ser Pro Val His Gln Asn Ala Ala Gln

50 55 60Ala Pro Pro Phe Leu Ile Met His Gly Thr Gly Asp Arg Met Val Pro 65 70 75 80Pro Glu Gln Ser Ala Ala Leu His Thr His Leu Val Gln Ala Gly Arg

85 90 95Gln Ser Thr Leu Val Leu Ile Glu Gly Phe Gly His Gly Phe Leu Asn

100 105 110Pro Gly Glu Val Ala Glu Leu Gly Pro Asn Val Arg Leu Asp Asn Gly

115 120 125Arg Leu Glu Arg Glu Pro Gln Thr Asn Phe Ser Ala Gln Gln Ser Pro

130 135 140Gly Asn Pro Phe Glu Leu Gln Gly Leu Ala Ala Asp His Glu Met Ile145 150 155 160Lys Arg Phe Phe Thr Leu His Leu Arg

165<210>205<211>1414<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1414)<223>RXN02947<400>205gtatgttcac acaagaaccc tgcacaacgc cttcaaagta cgtcgaccac gaccaagcgc 60attattcact ctcacccttc aggatttaga ctaagaaacc atg act gca gca cag 115

Met Thr Ala Ala Gln

1 5acc aaa cct gac ctc acc acc acg gct gga aag ctg tcc gat ctt cgc 163Thr Lys Pro Asp Leu Thr Thr Thr Ala Gly Lys Leu Ser Asp Leu Arg

10 15 20tcc cgt ctt gca gaa gct caa gct cca atg ggc gaa gca act gta gaa 211Ser Arg Leu Ala Glu Ala Gln Ala Pro Met Gly Glu Ala Thr Val Glu

25 30 35aaa gtg cac gct gct ggc agg aag act gcc cgc gaa cgt atc gag tat 259Lys Val His Ala Ala Gly Arg Lys Thr Ala Arg Glu Arg Ile Glu Tyr

40 45 50ttg ctc gat gag ggc tct ttc gta gag atc gat gct ctt gct cgt cac 307Leu Leu Asp Glu Gly Ser Phe Val Glu Ile Asp Ala Leu Ala Arg His

55 60 65cgt tcc aag aac ttc ggc ctg gat gcc aag cgt cca gtt act gac ggt 355Arg Ser Lys Asn Phe Gly Leu Asp Ala Lys Arg Pro Val Thr Asp Gly 70 75 80 85gtt gtg act ggt tac ggc acc atc gat ggc cgt aag gtc tgt gtg ttc 403Val Val Thr Gly Tyr Gly Thr Ile Asp Gly Arg Lys Val Cys Val Phe

90 95 100tcc cag gac ggc gct gta ttc ggt ggc gct ttg ggt gaa gtt tat ggt 451Ser Gln Asp Gly Ala Val Phe Gly Gly Ala Leu Gly Glu Val Tyr Gly

105 110 115gaa aag atc gtt aag gtt atg gat ctt gcg atc aag acc ggt gtg cct 499Glu Lys Ile Val Lys Val Met Asp Leu Ala Ile Lys Thr Gly Val Pro

120 125 130ttg atc gga atc aat gag ggt gct ggt gcg cgt atc cag gaa ggt gtt 547Leu Ile Gly Ile Asn Glu Gly Ala Gly Ala Arg Ile Gln Glu Gly Val

135 140 145gtg tct ctg ggt ctg tac tca cag atc ttc tac cgc aac acc cag gcg 595Val Ser Leu Gly Leu Tyr Ser Gln Ile Phe Tyr Arg Asn Thr Gln Ala150 155 160 165tct ggc gtt atc cca cag atc tct ttg atc atg ggt gcc tgc gct ggt 643Ser Gly Val Ile Pro Gln Ile Ser Leu Ile Met Gly Ala Cys Ala Gly

170 175 180ggt cac gtg tac tcc cct gct ctg act gac ttc atc gtc atg gtg gat 691Gly His Val Tyr Ser Pro Ala Leu Thr Asp Phe Ile Val Met Val Asp

185 190 195cag act tcc aag atg ttt atc acc ggc cct gat gtc atc aag act gtc 739Gln Thr Ser Lys Met Phe Ile Thr Gly Pro Asp Val Ile Lys Thr Val

200 205 210acc ggt gaa gat gtc acccag gag gag ctc ggt ggc gct cac acc cac 787Thr Gly Glu Asp Val Thr Gln Glu Glu Leu Gly Gly Ala His Thr His

215 220 225atg gct acc tcc ggt acc tcc cat tac tct gct tct gat gat tca gat 835Met Ala Thr Ser Gly Thr Ser His Tyr Ser Ala Ser Asp Asp Ser Asp230 235 240 245gct ttg gat tgg gtt cgc gag ctg acc tct tat ctt cca tcc aac aac 883Ala Leu Asp Trp Val Arg Glu Leu Thr Ser Tyr Leu Pro Ser Asn Asn

250 255 260cgt gcg gaa act cct cgc cag gag gcc gac atc atg atc ggt tcc atc 931Arg Ala Glu Thr Pro Arg Gln Glu Ala Asp Ile Met Ile Gly Ser Ile

265 270 275cag gaa aac atc aac gat gtg gat ctg gaa ttg gac acc atc atc ccg 979Gln Glu Asn Ile Asn Asp Val Asp Leu Glu Leu Asp Thr Ile Ile Pro

280 285 290gat tcc ccg aac cag cct tat gac atg aag gaa gtt att tcc cgc atc 1027Asp Ser Pro Asn Gln Pro Tyr Asp Met Lys Glu Val Ile Ser Arg Ile

295 300 305gtc gac gac gcc gag ttc ttc gag atc cag gaa gac tac gca gag aac 1075Val Asp Asp Ala Glu Phe Phe Glu Ile Gln Glu Asp Tyr Ala Glu Asn310 315 320 325atc ctg tgt ggc ttc gct cgc gtt gag gtc cgt tct gtt ggc atc gtg 1123Ile Leu Cys Gly Phe Ala Arg Val Glu Val Arg Ser Val Gly Ile Val

330 335 340gct aac cag cca acc cag ttc gct ggc tgc ttg gat att aag gca tct 1171Ala Asn Gln Pro Thr Gln Phe Ala Gly Cys Leu Asp Ile Lys Ala Ser

345 350 355gag aag gct gcc cgt ttc atc cgc acc tgc gat gcc ttc aac atc cca 1219Glu Lys Ala Ala Arg Phe Ile Arg Thr Cys Asp Ala Phe Asn Ile Pro

360 365 370atc ctt gag ttc gtg gac gtt cca ggc ttc ctg cct ggc acc aac cag 1267Ile Leu Glu Phe Val Asp Val Pro Gly Phe Leu Pro Gly Thr Asn Gln

375 380 385gaa ttc gac ggc atc atc cgc cgc ggc gca aag ctg ctt tac gct tac 1315Glu Phe Asp Gly Ile Ile Arg Arg Gly Ala Lys Leu Leu Tyr Ala Tyr390 395 400 405gct gaa gca acc gtc ggc aag atc acc gtc atc acc cgc aag tcc tac 1363Ala Glu Ala Thr Val Gly Lys Ile Thr Val Ile Thr Arg Lys Ser Tyr

410 415 420ggc gga gcg tac tgc gtg atg ggt tcc aag gat atg ggc gct ggc ctg 1411Gly Gly Ala Tyr Cys Val Met Gly Ser Lys Asp Met Gly Ala Gly Leu

425430435 gta1414Val<210>206<211>438<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>206Met Thr Ala Ala Gln Thr Lys Pro Asp Leu Thr Thr Thr Ala Gly Lys 151015 Leu Ser Asp Leu Arg Ser Arg Leu Ala Glu Ala Gln Ala Pro Met Gly

20 25 30Glu Ala Thr Val Glu Lys Val His Ala Ala Gly Arg Lys Thr Ala Arg

35 40 45Glu Arg Ile Glu Tyr Leu Leu Asp Glu Gly Ser Phe Val Glu Ile Asp

50 55 60Ala Leu Ala Arg His Arg Ser Lys Asn Phe Gly Leu Asp Ala Lys Arg 65 70 75 80Pro Val Thr Asp Gly Val Val Thr Gly Tyr Gly Thr Ile Asp Gly Arg

85 90 95Lys Val Cys Val Phe Ser Gln Asp Gly Ala Val Phe Gly Gly Ala Leu

100 105 110Gly Glu Val Tyr Gly Glu Lys Ile Val Lys Val Met Asp Leu Ala Ile

115 120 125Lys Thr Gly Val Pro Leu Ile Gly Ile Asn Glu Gly Ala Gly Ala Arg

130 135 140Ile Gln Glu Gly Val Val Ser Leu Gly Leu Tyr Ser Gln Ile Phe Tyr145 150 155 160Arg Asn Thr Gln Ala Ser Gly Val Ile Pro Gln Ile Ser Leu Ile Met

165 170 175Gly Ala Cys Ala Gly Gly His Val Tyr Ser Pro Ala Leu Thr Asp Phe

180 185 190Ile Val Met Val Asp Gln Thr Ser Lys Met Phe Ile Thr Gly Pro Asp

195 200 205Val Ile Lys Thr Val Thr Gly Glu Asp Val Thr Gln Glu Glu Leu Gly

210 215 220Gly Ala His Thr His Met Ala Thr Ser Gly Thr Ser His Tyr Ser Ala225 230 235 240Ser Asp Asp Ser Asp Ala Leu Asp Trp Val Arg Glu Leu Thr Ser Tyr

245 250 255Leu Pro Ser Asn Asn Arg Ala Glu Thr Pro Arg Gln Glu Ala Asp Ile

260 265 270Met Ile Gly Ser Ile Gln Glu Asn Ile Asn Asp Val Asp Leu Glu Leu

275 280 285Asp Thr Ile Ile Pro Asp Ser Pro Asn Gln Pro Tyr Asp Met Lys Glu

290 295 300Val Ile Ser Arg Ile Val Asp Asp Ala Glu Phe Phe Glu Ile Gln Glu305 310 315 320Asp Tyr Ala Glu Asn Ile Leu Cys Gly Phe Ala Arg Val Glu Val Arg

325 330 335Ser Val Gly Ile Val Ala Asn Gln Pro Thr Gln Phe Ala Gly Cys Leu

340 345 350Asp Ile Lys Ala Ser Glu Lys Ala Ala Arg Phe Ile Arg Thr Cys Asp

355 360 365Ala Phe Asn Ile Pro Ile Leu Glu Phe Val Asp Val Pro Gly Phe Leu

370 375 380Pro Gly Thr Asn Gln Glu Phe Asp Gly Ile Ile Arg Arg Gly Ala Lys385 390 395 400Leu Leu Tyr Ala Tyr Ala Glu Ala Thr Val Gly Lys Ile Thr Val Ile

405 410 415Thr Arg Lys Ser Tyr Gly Gly Ala Tyr Cys Val Met Gly Ser Lys Asp

420 425 430Met Gly Ala Gly Leu Val

435<210>207<211>688<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (688)<223>FRXA02320<400>207gtatgttcac acaagaaccc tgcacaacgc cttcaaagta cgtcgaccac gaccaagcgc 60attattcact ctcacccttc aggatttaga ctaagaaacc atg act gca gca cag 115

Met Thr Ala Ala Gln

1 5acc aaa cct gac ctc acc acc acg gct gga aag ctg tcc gat ctt cgc 163Thr Lys Pro Asp Leu Thr Thr Thr Ala Gly Lys Leu Ser Asp Leu Arg

10 15 20tcc cgt ctt gca gaa gct caa gct cca atg ggc gaa gca act gta gaa 211Ser Arg Leu Ala Glu Ala Gln Ala Pro Met Gly Glu Ala Thr Val Glu

25 30 35aaa gtg cac gct gct ggc agg aag act gcc cgc gaa cgt atc gag tat 259Lys Val His Ala Ala Gly Arg Lys Thr Ala Arg Glu Arg Ile Glu Tyr

40 4550ttg ctc gat gag ggc tct ttc gta gag atc gat gct ctt gct cgt cac 307Leu Leu Asp Glu Gly Ser Phe Val Glu Ile Asp Ala Leu Ala Arg His

55 60 65cgt tcc aag aac ttc ggc ctg gat gcc aag cgt cca gtt act gac ggt 355Arg Ser Lys Asn Phe Gly Leu Asp Ala Lys Arg Pro Val Thr Asp Gly 70 75 80 85gtt gtg act ggt tac ggc acc atc gat ggc cgt aag gtc tgt gtg ttc 403Val Val Thr Gly Tyr Gly Thr Ile Asp Gly Arg Lys Val Cys Val Phe

90 95 100tcc cag gac ggc gct gta ttc ggt ggc gct ttg ggt gaa gtt tat ggt 451Ser Gln Asp Gly Ala Val Phe Gly Gly Ala Leu Gly Glu Val Tyr Gly

105 110 115gaa aag atc gtt aag gtt atg gat ctt gcg atc aag acc ggt gtg cct 499Glu Lys Ile Val Lys Val Met Asp Leu Ala Ile Lys Thr Gly Val Pro

120 125 130ttg atc gga atc aat gag ggt gct ggt gcg cgt atc cag gaa ggt gtt 547Leu Ile Gly Ile Asn Glu Gly Ala Gly Ala Arg Ile Gln Glu Gly Val

135 140 145gtg tct ctg ggt ctg tac tca cag atc ttc tac cgc aac acc cag gcg 595Val Ser Leu Gly Leu Tyr Ser Gln Ile Phe Tyr Arg Asn Thr Gln Ala150 155 160 165tct ggc gtt atc cca cag atc tct ttg atc atg ggt gcc tgc gct ggt 643Ser Gly Val Ile Pro Gln Ile Ser Leu Ile Met Gly Ala Cys Ala Gly

170 175 180ggt cac gtg tac tcc cct gct ctg act gac ttc atc gtc atg gtg 688Gly His Val Tyr Ser Pro Ala Leu Thr Asp Phe Ile Val Met Val

185190195<210>208<211>196<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>208Met Thr Ala Ala GlnThr Lys Pro Asp Leu Thr Thr Thr Ala Gly Lys 151015 Leu Ser Asp Leu Arg Ser Arg Leu Ala Glu Ala Gln Ala Pro Met Gly

20 25 30Glu Ala Thr Val Glu Lys Val His Ala Ala Gly Arg Lys Thr Ala Arg

35 40 45Glu Arg Ile Glu Tyr Leu Leu Asp Glu Gly Ser Phe Val Glu Ile Asp

50 55 60Ala Leu Ala Arg His Arg Ser Lys Asn Phe Gly Leu Asp Ala Lys Arg 65 70 75 80 Pro Val Thr Asp Gly Val Val Thr Gly Tyr Gly Thr Ile Asp Gly Arg

85 90 95Lys Val Cys Val Phe Ser Gln Asp Gly Ala Val Phe Gly Gly Ala Leu

100 105 110Gly Glu Val Tyr Gly Glu Lys Ile Val Lys Val Met Asp Leu Ala Ile

115 120 125Lys Thr Gly Val Pro Leu Ile Gly Ile Asn Glu Gly Ala Gly Ala Arg

130 135 140Ile Gln Glu Gly Val Val Ser Leu Gly Leu Tyr Ser Gln Ile Phe Tyr145 150 155 160Arg Asn Thr Gln Ala Ser Gly Val Ile Pro Gln Ile Ser Leu Ile Met

165 170 175Gly Ala Cys Ala Gly Gly His Val Tyr Ser Pro Ala Leu Thr Asp Phe

180 185 190Ile Val Met Val

195<210>209<211>519<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) }, (519)<223>FRXA02851<220><221>misc _ feature<222>135<223>n represents any nucleotide<220><221>misc _ feature<222>209<223>n represents any nucleotide<220><221>misc _ feature<222>215<223>n represents any nucleotide<220><221>misc _ feature<222>258<223>n represents any nucleotide<220><221>variant<222>70<223>Xaa Val, Ala, Asp or Gly<220><221><222>72<223>Xaa Phe or<220><221>85<223>Xaa codon<84 Xaa<85 or<209>85aAC<84<8526>500<220>85aP>500<220>or<220><221>variants<222>221>85<223>Xaa<84 gat gtg gat ctg gaa ttg gac acc atc atc ccg gat tcc ccg aac 96Asn Asp Val Asp Leu Glu Leu Asp Thr Ile Ile Pro Asp Ser Pro Asn

20 25 30cag cct tat gac atg aag gaa gtt att tcc cgc atc gtn gac gac gcc 144Gln Pro Tyr Asp Met Lys Glu Val Ile Ser Arg Ile Val Asp Asp Ala

35 40 45gag ttc ttc gag atc cag gaa gac tac gca gag aac atc ctg tgt ggc 192Glu Phe Phe Glu Ile Gln Glu Asp Tyr Ala Glu Asn Ile Leu Cys Gly

50 55 60ttc gct cgc gtt gag gnc cgt tnt gtt ggc atc gtg gct aac cag cca 240Phe Ala Arg Val Glu Xaa Arg Xaa Val Gly Ile Val Ala Asn Gln Pro 65 70 75 80acc cag ttc gct ggc tgn ttg gat att aag gca tct gag aag gct gcc 288Thr Gln Phe Ala Gly Xaa Leu Asp Ile Lys Ala Ser Glu Lys Ala Ala

85 90 95cgt ttc atc cgc acc tgc gat gcc ttc aac atc cca atc ctt gag ttc 336Arg Phe Ile Arg Thr Cys Asp Ala Phe Asn Ile Pro Ile Leu Glu Phe

100 105 110gtg gac gtt cca ggc ttc ctg cct ggc acc aac cag gaa ttc gac ggc 384Val Asp Val Pro Gly Phe Leu Pro Gly Thr Asn Gln Glu Phe Asp Gly

115 120 125atc atc cgc cgc ggc gca aag ctg ctt tac gct tac gct gaa gca acc 432Ile Ile Arg Arg Gly Ala Lys Leu Leu Tyr Ala Tyr Ala Glu Ala Thr

130 135 140gtc ggc aag atc acc gtc atc acc cgc aag tcc tac ggc gga gcg tac 480Val Gly Lys Ile Thr Val Ile Thr Arg Lys Ser Tyr Gly Gly Ala Tyr145 150 155 160tgc gtg atg ggt tcc aag gat atg ggc gct ggc ctg gta 519Cys Val Met Gly Ser Lys Asp Met Gly Ala Gly Leu Val

165170<210>210<211>173<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>variant<222>70<223>Xaa Val, Ala, Asp or Gly<220><221>variant<222>72<223>Xaa Phe or Leu<220><221>variant<222>86<223>Xaa Cys, Trp or stop codon<400>210Pro Arg Gln Lys Ala Asp Ile Met Ile Gly Ser Ile Gln Glu Asn Ile 151015 Asn Asp Val Asp Leu Glu Leu Asp Thr Ile Ile Pro Asp Ser Pro Asn

20 25 30Gln Pro Tyr Asp Met Lys Glu Val Ile Ser Arg Ile Val Asp Asp Ala

35 40 45Glu Phe Phe Glu Ile Gln Glu Asp Tyr Ala Glu Asn Ile Leu Cys Gly

50 55 60Phe Ala Arg Val Glu Xaa Arg Xaa Val Gly Ile Val Ala Asn Gln Pro 65 70 75 80Thr Gln Phe Ala Gly Xaa Leu Asp Ile Lys Ala Ser Glu Lys Ala Ala

85 90 95Arg Phe Ile Arg Thr Cys Asp Ala Phe Asn Ile Pro Ile Leu Glu Phe

100 105 110Val Asp Val Pro Gly Phe Leu Pro Gly Thr Asn Gln Glu Phe Asp Gly

115 120 125Ile Ile Arg Arg Gly Ala Lys Leu Leu Tyr Ala Tyr Ala Glu Ala Thr

130 135 140Val Gly Lys Ile Thr Val Ile Thr Arg Lys Ser Tyr Gly Gly Ala Tyr145 150 155 160Cys Val Met Gly Ser Lys Asp Met Gly Ala Gly Leu Val

165170<210>211<211>1752<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1729)<223>RXN02321<400>211tttaaaaact acccgcacgc agcacgaacc tgttcagtga tgtaaatcac cgcggaaata 60ttgtggacgt tacccccgcc taccgctacg atttcaaaac atg acc att tcc tca 115

Met Thr Ile Ser Ser

1 5cct ttg att gac gtc gcc aac ctt cca gac atc aac acc act gcc ggc 163Pro Leu Ile Asp Val Ala Asn Leu Pro Asp Ile Asn Thr Thr Ala Gly

10 15 20aag atc gcc gac ctt aag gct cgc cgc gcg gaa gcc cat ttc ccc atg 211Lys Ile Ala Asp Leu Lys Ala Arg Arg Ala Glu Ala His Phe Pro Met

25 30 35ggt gaa aag gca gta gag aag gtc cac gct gct gga cgc ctc act gcc 259Gly Glu Lys Ala Val Glu Lys Val His Ala Ala Gly Arg Leu Thr Ala

40 45 50cgt gag cgc ttg gat tac tta ctc gat gag ggc tcc ttc atc gag acc 307Arg Glu Arg Leu Asp Tyr Leu Leu Asp Glu Gly Ser Phe Ile Glu Thr

55 60 65gat cag ctg gct cgc cac cgc acc acc gct ttc tgc ctg ggc gct aag 355Asp Gln Leu Ala Arg His Arg Thr Thr Ala Phe Cys Leu Gly Ala Lys 70 75 80 85cgt cct gca acc gac ggt atc gtg acc ggc tgg ggc acc att gat gga 403Arg Pro Ala Thr Asp Gly Ile Val Thr Gly Trp Gly Thr Ile Asp Gly

90 95 100cgc gaa gtc tgc atc ttc tcg cag gac ggc acc gta ttc ggt ggc gcg 451Arg Glu Val Cys Ile Phe Ser Gln Asp Gly Thr Val Phe Gly Gly Ala

105 110 115ctt ggt gag gtg tac ggc gaa aag atg atc aag atc atg gag ctg gca 499Leu Gly Glu Val Tyr Gly Glu Lys Met Ile Lys Ile Met Glu Leu Ala

120 125 130atc gac acc ggc cgc cca ttg atc ggt ctt tac gaa ggc gct ggc gct 547Ile Asp Thr Gly Arg Pro Leu Ile Gly Leu Tyr Glu Gly Ala Gly Ala

135 140 145cgt att cag gac ggc gct gtc tcc ctg gac ttc att tcc cag acc ttc 595Arg Ile Gln Asp Gly Ala Val Ser Leu Asp Phe Ile Ser Gln Thr Phe150 155 160 165tac caa aac att cag gct tct ggc gtt atc cca cag atc tcc gtc atc 643Tyr Gln Asn Ile Gln Ala Ser Gly Val Ile Pro Gln Ile Ser Val Ile

170 175 180atg ggc gca tgt gca ggt ggc aac gct tac ggc cca gct ctg acc gac 691Met Gly Ala Cys Ala Gly Gly Asn Ala Tyr Gly Pro Ala Leu Thr Asp

185 190 195ttc gtg gtc atg gtg gac aag acc tcc aag atg ttc gtt acc ggc cca 739Phe Val Val Met Val Asp Lys Thr Ser Lys Met Phe Val Thr Gly Pro

200 205 210gac gtg atc aag acc gtc acc ggc gag gaa atc acc cag gaa gag ctt 787Asp Val Ile Lys Thr Val Thr Gly Glu Glu Ile Thr Gln Glu Glu Leu

215 220 225ggc gga gca acc acc cac atg gtg acc gct ggt aac tcc cac tac acc 835Gly Gly Ala Thr Thr His Met Val Thr Ala Gly Asn Ser His Tyr Thr230 235 240 245gct gcg acc gat gag gaa gca ctg gat tgg gta cag gac ctg gtg tcc 883Ala Ala Thr Asp Glu Glu Ala Leu Asp Trp Val Gln Asp Leu Val Ser

250 255 260ttc ctc cca tcc aac aat cgc tcc tac gca ccg atg gaa gac ttc gac 931Phe Leu Pro Ser Asn Asn Arg Ser Tyr Ala Pro Met Glu Asp Phe Asp

265 270 275gag gaa gaa ggc ggc gtt gaa gaa aac atc acc gct gac gat ctg aag 979Glu Glu Glu Gly Gly Val Glu Glu Asn Ile Thr Ala Asp Asp Leu Lys

280 285 290ctc gac gag atc atc cca gat tcc gcg acc gtt cct tac gac gtc cgc 1027Leu Asp Glu Ile Ile Pro Asp Ser Ala Thr Val Pro Tyr Asp Val Arg

295 300 305gat gtc atc gaa tgc ctc acc gac gat ggc gaa tac ctg gaa atc cag 1075Asp Val Ile Glu Cys Leu Thr Asp Asp Gly Glu Tyr Leu Glu Ile Gln310 315 320 325gca gac cgc gca gaa aac gtt gtt att gca ttc ggc cgc atc gaa ggc 1123Ala Asp Arg Ala Glu Asn Val Val Ile Ala Phe Gly Arg Ile Glu Gly

330 335 340cag tcc gtt ggc ttt gtt gcc aac cag cca acc cag ttc gct ggc tgc 1171Gln Ser Val Gly Phe Val Ala Asn Gln Pro Thr Gln Phe Ala Gly Cys

345 350 355ctg gac atc gac tcc tct gag aag gca gct cgc ttc gtc cgc acc tgc 1219Leu Asp Ile Asp Ser Ser Glu Lys Ala Ala Arg Phe Val Arg Thr Cys

360 365 370gac gcg ttc aac atc cca atc gtc atg ctt gtc gac gtc ccc ggc ttc 1267Asp Ala Phe Asn Ile Pro Ile Val Met Leu Val Asp Val Pro Gly Phe

375 380 385ctc cca ggc gca ggc cag gag tac ggt ggc att ctg cgt cgt ggc gca 1315Leu Pro Gly Ala Gly Gln Glu Tyr Gly Gly Ile Leu Arg Arg Gly Ala390 395 400 405aag ctg ctc tac gca tac ggc gaa gca acc gtt cca aag atc acc gtc 1363Lys Leu Leu Tyr Ala Tyr Gly Glu Ala Thr Val Pro Lys Ile Thr Val

410 415 420acc atg cgt aag gct tac ggc gga gcg tac tgc gtg atg ggt tcc aag 1411Thr Met Arg Lys Ala Tyr Gly Gly Ala Tyr Cys Val Met Gly Ser Lys

425 430 435ggc ttg ggc tct gac atc aac ctt gca tgg cca acc gca cag atc gcc 1459Gly Leu Gly Ser Asp Ile Asn Leu Ala Trp Pro Thr Ala Gln Ile Ala

440 445 450gtc atg ggc gct gct ggc gca gtt gga ttc atc tac cgc aag gag ctc 1507Val Met Gly Ala Ala Gly Ala Val Gly Phe Ile Tyr Arg Lys Glu Leu

455 460 465atg gca gct gat gcc aag ggc ctc gat acc gta gct ctg gct aag tcc 1555Met Ala Ala Asp Ala Lys Gly Leu Asp Thr Val Ala Leu Ala Lys Ser470 475 480 485ttc gag cgc gag tat gaa gac cac atg ctc aac ccg tac cac gct gca 1603Phe Glu Arg Glu Tyr Glu Asp His Met Leu Asn Pro Tyr His Ala Ala

490 495 500gaa cgt ggc ctg atc gac gcc gtg atc ctg cca agc gaa acc cgc gga 1651Glu Arg Gly Leu Ile Asp Ala Val Ile Leu Pro Ser Glu Thr Arg Gly

505 510 515cag att tcc cgc aac ctt cgc ctg ctc aag cac aag aac gtc act cgc 1699Gln Ile Ser Arg Asn Leu Arg Leu Leu Lys His Lys Asn Val Thr Arg

520 525 530cct gct cgc aag cac ggc aac atg cca ctg taaatcggcg aatccataaa 1749Pro Ala Arg Lys His Gly Asn Met Pro Leu

535540 ggt1752<210>212<211>543<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>212Met Thr Ile Ser Ser Pro Leu Ile Asp Val Ala Asn Leu Pro Asp Ile 151015 Asn Thr Thr Ala Gly Lys Ile Ala Asp Leu Lys Ala Arg Arg Ala Glu

20 25 30Ala His Phe Pro Met Gly Glu Lys Ala Val Glu Lys Val His Ala Ala

35 40 45Gly Arg Leu Thr Ala Arg Glu Arg Leu Asp Tyr Leu Leu Asp Glu Gly

50 55 60Ser Phe Ile Glu Thr Asp Gln Leu Ala Arg His Arg Thr Thr Ala Phe 65 70 75 80Cys Leu Gly Ala Lys Arg Pro Ala Thr Asp Gly Ile Val Thr Gly Trp

85 90 95Gly Thr Ile Asp Gly Arg Glu Val Cys Ile Phe Ser Gln Asp Gly Thr

100 105 110Val Phe Gly Gly Ala Leu Gly Glu Val Tyr Gly Glu Lys Met Ile Lys

115 120 125Ile Met Glu Leu Ala Ile Asp Thr Gly Arg Pro Leu Ile Gly Leu Tyr

130 135 140Glu Gly Ala Gly Ala Arg Ile Gln Asp Gly Ala Val Ser Leu Asp Phe145 150 155 160Ile Ser Gln Thr Phe Tyr Gln Asn Ile Gln Ala Ser Gly Val Ile Pro

165 170 175Gln Ile Ser Val Ile Met Gly Ala Cys Ala Gly Gly Asn Ala Tyr Gly

180 185 190Pro Ala Leu Thr Asp Phe Val Val Met Val Asp Lys Thr Ser Lys Met

195 200 205Phe Val Thr Gly Pro Asp Val Ile Lys Thr Val Thr Gly Glu Glu Ile

210 215 220Thr Gln Glu Glu Leu Gly Gly Ala Thr Thr His Met Val Thr Ala Gly225 230 235 240Asn Ser His Tyr Thr Ala Ala Thr Asp Glu Glu Ala Leu Asp Trp Val

245 250 255Gln Asp Leu Val Ser Phe Leu Pro Ser Asn Asn Arg Ser Tyr Ala Pro

260 265 270Met Glu Asp Phe Asp Glu Glu Glu Gly Gly Val Glu Glu Asn Ile Thr

275 280 285Ala Asp Asp Leu Lys Leu Asp Glu Ile Ile Pro Asp Ser Ala Thr Val

290 295 300Pro Tyr Asp Val Arg Asp Val Ile Glu Cys Leu Thr Asp Asp Gly Glu305 310 315 320Tyr Leu Glu Ile Gln Ala Asp Arg Ala Glu Asn Val Val Ile Ala Phe

325 330 335Gly Arg Ile Glu Gly Gln Ser Val Gly Phe Val Ala Asn Gln Pro Thr

340 345 350Gln Phe Ala Gly Cys Leu Asp Ile Asp Ser Ser Glu Lys Ala Ala Arg

355 360 365Phe Val Arg Thr Cys Asp Ala Phe Asn Ile Pro Ile Val Met Leu Val

370 375 380Asp Val Pro Gly Phe Leu Pro Gly Ala Gly Gln Glu Tyr Gly Gly Ile385 390 395 400Leu Arg Arg Gly Ala Lys Leu Leu Tyr Ala Tyr Gly Glu Ala Thr Val

405 410 415Pro Lys Ile Thr Val Thr Met Arg Lys Ala Tyr Gly Gly Ala Tyr Cys

420 425 430Val Met Gly Ser Lys Gly Leu Gly Ser Asp Ile Asn Leu Ala Trp Pro

435 440 445Thr Ala Gln Ile Ala Val Met Gly Ala Ala Gly Ala Val Gly Phe Ile

450 455 460Tyr Arg Lys Glu Leu Met Ala Ala Asp Ala Lys Gly Leu Asp Thr Val465 470 475 480Ala Leu Ala Lys Ser Phe Glu Arg Glu Tyr Glu Asp His Met Leu Asn

485 490 495Pro Tyr His Ala Ala Glu Arg Gly Leu Ile Asp Ala Val Ile Leu Pro

500 505 510Ser Glu Thr Arg Gly Gln Ile Ser Arg Asn Leu Arg Leu Leu Lys His

515 520 525Lys Asn Val Thr Arg Pro Ala Arg Lys His Gly Asn Met Pro Leu

530535540<210>213<211>467<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (444)<223>FRXA02321<220><221>misc _ feature<222>50<223>n for any nucleotide<220><221>misc _ feature<222>51<223>n for any nucleotide<220><221>variant<222>17<223>Xaa-Val, Ala, asp, Glu or Gly<400>213gag tac ggt ggc att ctg cgt cgt ggc gca aag ctg ctc tac gca tcg 48Glu Tyr Gly Gly Ile Leu Arg Arg Gly Ala Lys Leu Leu Tyr Ala Ser 151015 gnn gaa gca ccg gtt cca aag atc acc gtc acc atg cgt aag gct tac 96Xaa Glu Ala Pro Val Pro Lys Ile Thr Val Thr Met Arg Lys Ala Tyr.

20 25 30ggc gga gcg tac tgc gtg atg ggt tcc aag ggc ttg ggc tct gac atc 144Gly Gly Ala Tyr Cys Val Met Gly Ser Lys Gly Leu Gly Ser Asp Ile

35 40 45aac ctt gca tgg cca acc gca cag atc gcc gtc atg ggc gct gct ggc 192Asn Leu AlaTrp Pro Thr Ala Gln Ile Ala Val Met Gly Ala Ala Gly

50 55 60gca gtt gga ttc atc tac cgc aag gag ctc atg gca gct gat gcc aag 240Ala Val Gly Phe Ile Tyr Arg Lys Glu Leu Met Ala Ala Asp Ala Lys 65 70 75 80ggc ctc gat acc gta gct ctg gct aag tcc ttc gag cgc gag tat gaa 288Gly Leu Asp Thr Val Ala Leu Ala Lys Ser Phe Glu Arg Glu Tyr Glu

85 90 95gac cac atg ctc aac ccg tac cac gct gca gaa cgt ggc ctg atc gac 336Asp His Met Leu Asn Pro Tyr His Ala Ala Glu Arg Gly Leu Ile Asp

100 105 110gcc gtg atc ctg cca agc gaa acc cgc gga cag att tcc cgc aac ctt 384Ala Val Ile Leu Pro Ser Glu Thr Arg Gly Gln Ile Ser Arg Asn Leu

115 120 125cgc ctg ctc aag cac aag aac gtc act cgc cct gct cgc aag cac ggc 432Arg Leu Leu Lys His Lys Asn Val Thr Arg Pro Ala Arg Lys His Gly

130135140 aac atg cca ctg taaatcggcg aatccataaa ggt 467Asn Met Pro Leu145<210>214<211>148<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>221>variant<222>17<223>Xaa ═ Val, Ala, Asp, Glu or Gly<400>214Glu Tyr Gly Gly Ile Leu Arg Arg Gly Ala Lys Leu Leu Tyr Ala Ser 151015 Xaa Glu Ala Pro Val Pro Lys Ile Thr Val Thr Met Arg Lys Ala Tyr

20 25 30Gly Gly Ala Tyr Cys Val Met Gly Ser Lys Gly Leu Gly Ser Asp Ile

35 40 45Asn Leu Ala Trp Pro Thr Ala Gln Ile Ala Val Met Gly Ala Ala Gly

50 55 60Ala Val Gly Phe Ile Tyr Arg Lys Glu Leu Met Ala Ala Asp Ala Lys 6570 75 80Gly Leu Asp Thr Val Ala Leu Ala Lys Ser Phe Glu Arg Glu Tyr Glu

85 90 95Asp His Met Leu Asn Pro Tyr His Ala Ala Glu Arg Gly Leu Ile Asp

100 105 110Ala Val Ile Leu Pro Ser Glu Thr Arg Gly Gln Ile Ser Arg Asn Leu

115 120 125Arg Leu Leu Lys His Lys Asn Val Thr Arg Pro Ala Arg Lys His Gly

130135140 Asn Met Pro Leu145<210>215<211>514<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (514)<223>FRXA02343<400>215tttaaaaact acccgcacgc agcacgaacc tgttcagtga tgtaaatcac cgcggaaata 60ttgtggacgt tacccccgcc taccgctacg atttcaaaac atg acc att tcc tca 115

Met Thr Ile Ser Ser

1 5cct ttg att gac gtc gcc aac ctt cca gac atc aac acc act gcc ggc 163Pro Leu Ile Asp Val Ala Asn Leu Pro Asp Ile Asn Thr Thr Ala Gly

10 15 20aag atc gcc gac ctt aag gct cgc cgc gcg gaa gcc cat ttc ccc atg 211Lys Ile Ala Asp Leu Lys Ala Arg Arg Ala Glu Ala His Phe Pro Met

25 30 35ggt gaa aag gca gta gag aag gtc cac gct gct gga cgc ctc act gcc 259Gly Glu Lys Ala Val Glu Lys Val His Ala Ala Gly Arg Leu Thr Ala

40 45 50cgt gag cgc ttg gat tac tta ctc gat gag ggc tcc ttc atc gag acc 307Arg Glu Arg Leu Asp Tyr Leu Leu Asp Glu Gly Ser Phe Ile Glu Thr

55 60 65gat cag ctg gct cgc cac cgc acc acc gct ttc tgc ctg ggc gct aag 355Asp Gln Leu Ala Arg His Arg Thr Thr Ala Phe Cys Leu Gly Ala Lys 70 75 80 85cgt cct gca acc gac ggc atc gtg acc ggc tgg ggc acc att gat gga 403Arg Pro Ala Thr Asp Gly Ile Val Thr Gly Trp Gly Thr Ile Asp Gly

90 95 100cgc gaa gtc tgc atc ttc tcg cag gac ggc acc gta ttc ggt ggc gcg 451Arg Glu Val Cys Ile Phe Ser Gln Asp Gly Thr Val Phe Gly Gly Ala

105 110 115ctt ggt gag gtg tac ggc gaa aag atg atc aag atc atg gag ctg gca 499Leu Gly Glu Val Tyr Gly Glu Lys Met Ile Lys Ile Met Glu Leu Ala

120 125 130atc gac acc ggc cgc 514Ile Asp Thr Gly Arg

135<210>216<211>138<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>216Met Thr Ile Ser Ser Pro Leu Ile Asp Val Ala Asn Leu Pro Asp Ile 151015 Asn Thr Thr Ala Gly Lys Ile Ala Asp Leu Lys Ala Arg Arg Ala Glu

20 25 30Ala His Phe Pro Met Gly Glu Lys Ala Val Glu Lys Val His Ala Ala

35 40 45Gly Arg Leu Thr Ala Arg Glu Arg Leu Asp Tyr Leu Leu Asp Glu Gly

50 55 60Ser Phe Ile Glu Thr Asp Gln Leu Ala Arg His Arg Thr Thr Ala Phe 65 70 75 80Cys Leu Gly Ala Lys Arg Pro Ala Thr Asp Gly Ile Val Thr Gly Trp

85 90 95Gly Thr Ile Asp Gly Arg Glu Val Cys Ile Phe Ser Gln Asp Gly Thr

100 105 110Val Phe GlyGly Ala Leu Gly Glu Val Tyr Gly Glu Lys Met Ile Lys

115 120 125Ile Met Glu Leu Ala Ile Asp Thr Gly Arg

130135<210>217<211>492<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (492)<223>FRXA02850<220><221>misc _ feature<222>258<223>n stands for any nucleotide<220><221>misc _ feature<222>302<223>n stands for any nucleotide<220><221>variant<222>86<223>Xa-Ile or Met<220><221>variant<222>101<223>Xaa-Val, Ala, asp or Gly<400>217gaa gag ctt ggc gga gca acc acc cac atg gtg acc gct ggt aac tcc 48Glu Glu Leu Gly Gly Ala Thr Thr His Met Val Thr Ala Gly Asn Ser 151015 cac tac acc gct gcg acc gat gag gaa gca ctg gat tgg gta cag gac 96His Tyr Thr Ala Ala Thr Asp Glu Glu Ala Leu Asp Trp Val Gln Asp.

20 25 30ctg gtg tcc ttc ctc cca tcc aac aat cgc tcc tac gca ccg atg gaa 144Leu Val Ser Phe Leu Pro Ser Asn Asn Arg Ser Tyr Ala Pro Met Glu

35 40 45gac ttc gac gag gaa gaa ggc ggc gtt gaa gaa aac atc acc gct gac 192Asp Phe Asp Glu Glu Glu Gly Gly Val Glu Glu Asn Ile Thr Ala Asp

50 55 60gat ctg aag ctc gac gag atc atc cca gat tcc gcg acc gtt cct tac 240Asp Leu Lys Leu Asp Glu Ile Ile Pro Asp Ser Ala Thr Val Pro Tyr 65 70 75 80gac gtc cgc gat gtc atn gaa tgc ctc acc gac gat ggc gaa tac ctg 288Asp Val Arg Asp Val Xaa Glu Cys Leu Thr Asp Asp Gly Glu Tyr Leu

85 90 95gaa atc cag gca gnc cgc gca gaa aac gtt gtt attgca ttc ggc cgc 336Glu Ile Gln Ala Xaa Arg Ala Glu Asn Val Val Ile Ala Phe Gly Arg

100 105 110atc gaa ggc cag tcc gtt ggc ttt gtt gcc aac cag cca acc cag ttc 384Ile Glu Gly Gln Ser yal Gly Phe Val Ala Asn Gln Pro Thr Gln Phe

115 120 125gct ggc tgc ctg gac atc gac tcc tct gag aag gca gct cgc ttc gtc 432Ala Gly Cys Leu Asp Ile Asp Ser Ser Glu Lys Ala Ala Arg Phe Val

130135140 cgc acc tgc gac gcg ttc aac atc cca atc gtc atg ctt gtg gac gtc 480Arg Thr Cys Asp Ala Phe Asn Ile Pro Ile Val Met Leu Val Asp Val 145150155160 ccc ggc ttc ctc 492Pro Gly Phe Leu<210>218<211>164<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>variant<222>86<223>Xaa ═ Ile or Met<220><221>variant<222>101<223>Xaa ═ Val, Ala, Asp or Gly<400>218Glu Glu Leu Gly Gly Ala Thr Thr His Met Val Thr Ala Gly Asn Ser 151015 His Tyr Thr Ala Ala Thr Asp Glu Glu Ala Leu Asp Trp Val Gln Asp

20 25 30Leu Val Ser Phe Leu Pro Ser Asn Asn Arg Ser Tyr Ala Pro Met Glu

35 40 45Asp Phe Asp Glu Glu Glu Gly Gly Val Glu Glu Asn Ile Thr Ala Asp

50 55 60Asp Leu Lys Leu Asp Glu Ile Ile Pro Asp Ser Ala Thr Val Pro Tyr 65 70 75 80Asp Val Arg Asp Val Xaa Glu Cys Leu Thr Asp Asp Gly Glu Tyr Leu

85 90 95Glu Ile Gln Ala Xaa Arg Ala Glu Asn Val Val Ile Ala Phe Gly Arg

100 105 110Ile Glu Gly Gln Ser Val Gly Phe Val Ala Asn Gln Pro ThrGln Phe

115 120 125Ala Gly Cys Leu Asp Ile Asp Ser Ser Glu Lys Ala Ala Arg Phe Val

130135140 Arg Thr Cys Asp Ala Phe Asn Ile Pro Ile Val Met Leu Val Asp Val 145150155160 Pro Gly Phe Leu<210>219<211>1671<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1648)<223>RXA02583<400>219cagttgtcga tgaaccagaa atcggcacag tcggagctca tttgagtcgc cgcattgatg 60agatttctcg gaagaattag taacggagag ctgacggaag ttg agt aac acc act 115

Leu Ser Asn Thr Thr

1 5act gca gag aag cta gcg gat ctg cgc gca cgc ctg gag att gcc aaa 163Thr Ala Glu Lys Leu Ala Asp Leu Arg Ala Arg Leu Glu Ile Ala Lys

10 15 20gac cca ggt agt gaa cgc gca cgt aaa aag cgc gac gag gaa ggc cga 211Asp Pro Gly Ser Glu Arg Ala Arg Lys Lys Arg Asp Glu Glu Gly Arg

25 30 35acc acc cct cgt cag cgt att gat gct ctg ctt gat gcc gga tcc ttt 259Thr Thr Pro Arg Gln Arg Ile Asp Ala Leu Leu Asp Ala Gly Ser Phe

40 45 50gtg gag atc ggc gca cta ggc cgt acc ccg gat gaa ccc gat gcg cct 307Val Glu Ile Gly Ala Leu Gly Arg Thr Pro Asp Glu Pro Asp Ala Pro

55 60 65tac tct gac ggt gtg gtg act ggt tat ggt cgc atc gat ggt cgc cca 355Tyr Ser Asp Gly Val Val Thr Gly Tyr Gly Arg Ile Asp Gly Arg Pro 70 75 80 85gtg gcc atc tac gcc cat gac aag acc gtt tac ggt ggt tcc gtg ggc 403Val Ala Ile Tyr Ala His Asp Lys Thr Val Tyr Gly Gly Ser Val Gly

90 95 100atg act ttc gga cgt aaa gtc agc gaa gtc atg gac atg gct atc cgc 451Met Thr Phe Gly Arg Lys Val Ser Glu Val Met Asp Met Ala Ile Arg

105 110 115att ggt tgc cca gtt atc ggt att cag gat tcc ggc gga gcc cgc att 499Ile Gly Cys Pro Val Ile Gly Ile Gln Asp Ser Gly Gly Ala Arg Ile

120 125 130cag gat gcg gtg acc tcc ttg gcg atg tac tca gag atc gcg cgt cgt 547Gln Asp Ala Val Thr Ser Leu Ala Met Tyr Ser Glu Ile Ala Arg Arg

135 140 145cag ctt ccg ctg tct ggc cgc agc cct cag att tcc atc atg ctg ggt 595Gln Leu Pro Leu Ser Gly Arg Ser Pro Gln Ile Ser Ile Met Leu Gly150 155 160 165aaa tcg gca ggt ggc gca gtg tat gca cct gtg acc act gac ttt gtt 643Lys Ser Ala Gly Gly Ala Val Tyr Ala Pro Val Thr Thr Asp Phe Val

170 175 180atc ggc gtt gat ggt gaa aca gaa atg tat gtc acc ggc cca gcc gtg 691Ile Gly Val Asp Gly Glu Thr Glu Met Tyr Val Thr Gly Pro Ala Val

185 190 195atc aag gaa gtc acc ggc gag cag atc act tcc gca gac ctc ggt ggc 739Ile Lys Glu Val Thr Gly Glu Gln Ile Thr Ser Ala Asp Leu Gly Gly

200 205 210ggt gcg cag cag atg caa aac ggc aac att tcc tat ttg gcg tcc tct 787Gly Ala Gln Gln Met Gln Asn Gly Asn Ile Ser Tyr Leu Ala Ser Ser

215 220 225gaa gaa gag gcc ctg aat atg gtc aag gat ttg ctc gac ttc ctg cct 835Glu Glu Glu Ala Leu Asn Met Val Lys Asp Leu Leu Asp Phe Leu Pro230 235 240 245ttg acc tgc aat gat cca gcc cct gtg ttt gca gca cca acg gat gaa 883Leu Thr Cys Asn Asp Pro Ala Pro Val Phe Ala Ala Pro Thr Asp Glu

250 255 260gag atc gcc tac gac gaa gct ctg aac tcg ttc atg cct gac gac act 931Glu Ile Ala Tyr Asp Glu Ala Leu Asn Ser Phe Met Pro Asp Asp Thr

265 270 275aac cag ggc tac gac atg cat gac ctg ctg gac aag ctt ttc gac gac 979Asn Gln Gly Tyr Asp Met His Asp Leu Leu Asp Lys Leu Phe Asp Asp

280 285 290gcc aac ctg ctg gaa atc caa gag gag tac gcc ccc aac ctg atc act 1027Ala Asn Leu Leu Glu Ile Gln Glu Glu Tyr Ala Pro Asn Leu Ile Thr

295 300 305acc ttc gcc cgc gtt gat ggc aag gca gtc ggt gtg gtg gcc aac caa 1075Thr Phe Ala Arg Val Asp Gly Lys Ala Val Gly Val Val Ala Asn Gln310 315 320 325cca atg gat aag gca ggc tgc atc gac gct gac gcc gcc gac aag ggc 1123Pro Met Asp Lys Ala Gly Cys Ile Asp Ala Asp Ala Ala Asp Lys Gly

330 335 340gcc cgc ttc atc cgt atc tgc gac gcc tac aac atc ccg atc atc ttc 1171Ala Arg Phe Ile Arg Ile Cys Asp Ala Tyr Asn Ile Pro Ile Ile Phe

345 350 355gtc gtg gac acc cct ggc tac ctg cct ggc gtg gac caa gag aag gtc 1219Val Val Asp Thr Pro Gly Tyr Leu Pro Gly Val Asp Gln Glu Lys Val

360 365 370ggt ttg att cac cgt ggc gca aag cta gcc ttc gca gtg gtg gaa tcg 1267Gly Leu Ile His Arg Gly Ala Lys Leu Ala Phe Ala Val Val Glu Ser

375 380 385acc gtc cct aag att tcc ttg atc gtg cgc aag gcc tac ggc gga gca 1315Thr Val Pro Lys Ile Ser Leu Ile Val Arg Lys Ala Tyr Gly Gly Ala390 395 400 405tat gcc gtg atg ggt tcc aag aac ctc acc ggt gac ctc aac ttc gca 1363Tyr Ala Val Met Gly Ser Lys Asn Leu Thr Gly Asp Leu Asn Phe Ala

410 415 420tgg cca acc gca cag atc gcc gtg atg ggc gca gcc gca gct gtc gtg 1411Trp Pro Thr Ala Gln Ile Ala Val Met Gly Ala Ala Ala Ala Val Val

425 430 435atg atc cag ggc aag cag ctc gaa gcc gcc cca cct gag cag cgt gaa 1459Met Ile Gln Gly Lys Gln Leu Glu Ala Ala Pro Pro Glu Gln Arg Glu

440 445 450tac atg aag aaa ctg ttc atg gac ttc tac gat gag aac atg acc agc 1507Tyr Met Lys Lys Leu Phe Met Asp Phe Tyr Asp Glu Asn Met Thr Ser

455 460 465cca tat gtg gcc gcc gag cgt ggt tac atc gac gcc atg atc gaa cct 1555Pro Tyr Val Ala Ala Glu Arg Gly Tyr Ile Asp Ala Met Ile Glu Pro470 475 480 485gca gag acc cgt ttg gtg ctt cgc cga gca gtc cgc cag ctg gaa acc 1603Ala Glu Thr Arg Leu Val Leu Arg Arg Ala Val Arg Gln Leu Glu Thr

490 495 500aag gct gtg cga gac ctc gac aag aag cac acg atc atg ccg atg 1648Lys Ala Val Arg Asp Leu Asp Lys Lys His Thr Ile Met Pro Met

505510515 taacgtccaa agaattatcc aga 1671<210>220<211>516<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>220Leu Ser Asn Thr Thr Thr Ala Glu Lys Leu Ala Asp Leu Arg Ala Arg 151015 Leu Glu Ile Ala Lys Asp Pro Gly Ser Glu Arg Ala Arg Lys Lys Arg

20 25 30Asp Glu Glu Gly Arg Thr Thr Pro Arg Gln Arg Ile Asp Ala Leu Leu

3540 45Asp Ala Gly Ser Phe Val Glu Ile Gly Ala Leu Gly Arg Thr Pro Asp

50 55 60Glu Pro Asp Ala Pro Tyr Ser Asp Gly Val Val Thr Gly Tyr Gly Arg 65 70 75 80Ile Asp Gly Arg Pro Val Ala Ile Tyr Ala His Asp Lys Thr Val Tyr

85 90 95Gly Gly Ser Val Gly Met Thr Phe Gly Arg Lys Val Ser Glu Val Met

100 105 110Asp Met Ala Ile Arg Ile Gly Cys Pro Val Ile Gly Ile Gln Asp Ser

115 120 125Gly Gly Ala Arg Ile Gln Asp Ala Val Thr Ser Leu Ala Met Tyr Ser130 135 140Glu Ile Ala Arg Arg Gln Leu Pro Leu Ser Gly Arg Ser Pro Gln Ile145 150 155 160Ser Ile Met Leu Gly Lys Ser Ala Gly Gly Ala Val Tyr Ala Pro Val

165 170 175Thr Thr Asp Phe Val Ile Gly Val Asp Gly Glu Thr Glu Met Tyr Val

180 185 190Thr Gly Pro Ala Val Ile Lys Glu Val Thr Gly Glu Gln Ile Thr Ser

195 200 205Ala Asp Leu Gly Gly Gly Ala Gln Gln Met Gln Asn Gly Asn Ile Ser

210 215 220Tyr Leu Ala Ser Ser Glu Glu Glu Ala Leu Asn Met Val Lys Asp Leu225 230 235 240Leu Asp Phe Leu Pro Leu Thr Cys Asn Asp Pro Ala Pro Val Phe Ala

245 250 255Ala Pro Thr Asp Glu Glu Ile Ala Tyr Asp Glu Ala Leu Asn Ser Phe

260 265 270Met Pro Asp Asp Thr Asn Gln Gly Tyr Asp Met His Asp Leu Leu Asp

275 280 285Lys Leu Phe Asp Asp Ala Asn Leu Leu Glu Ile Gln Glu Glu Tyr Ala

290 295 300Pro Asn Leu Ile Thr Thr Phe Ala Arg Val Asp Gly Lys Ala Val Gly305 310 315 320Val Val Ala Asn Gln Pro Met Asp Lys Ala Gly Cys Ile Asp Ala Asp

325 330 335Ala Ala Asp Lys Gly Ala Arg Phe Ile Arg Ile Cys Asp Ala Tyr Asn

340 345 350Ile Pro Ile Ile Phe Val Val Asp Thr Pro Gly Tyr Leu Pro Gly Val

355 360 365Asp Gln Glu Lys Val Gly Leu Ile His Arg Gly Ala Lys Leu Ala Phe

370 375 380Ala Val Val Glu Ser Thr Val Pro Lys Ile Ser Leu Ile Val Arg Lys385 390 395 400Ala Tyr Gly Gly Ala Tyr Ala Val Met Gly Ser Lys Asn Leu Thr Gly

405 410 415Asp Leu Asn Phe Ala Trp Pro Thr Ala Gln Ile Ala Val Met Gly Ala

420 425 430Ala Ala Ala Val Val Met Ile Gln Gly Lys Gln Leu Glu Ala Ala Pro

435 440 445Pro Glu Gln Arg Glu Tyr Met Lys Lys Leu Phe Met Asp Phe Tyr Asp

450 455 460Glu Asn Met Thr Ser Pro Tyr Val Ala Ala Glu Arg Gly Tyr Ile Asp465 470 475 480Ala Met Ile Glu Pro Ala Glu Thr Arg Leu Val Leu Arg Arg Ala Val

485 490 495Arg Gln Leu Glu Thr Lys Ala Val Arg Asp Leu Asp Lys Lys His Thr

500 505 510Ile Met Pro Met

515<210>221<211>1635<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1612)<223>RXA00870<400>221caagacggcg atgtcgccgc cgctgttgat accgcagcgc gacttgttca cacagatatt 60caacaattca cttcgcagag catttaagga atttacacac atg tct gaa cca caa 115

Met Ser Glu Pro Gln

1 5acc atc tcg cac tgg att gac ggc gcg att tcc cca tcc act tcc ggc 163Thr Ile Ser His Trp Ile Asp Gly Ala Ile Ser Pro Ser Thr Ser Gly

10 15 20aag acc gct cct gtc tac aat cct gca act ggc cag gtc acc gcc aat 211Lys Thr Ala Pro Val Tyr Asn Pro Ala Thr Gly Gln Val Thr Ala Asn

25 30 35gtt gcg ctg gct agc cag gaa gag atc gat gcc acc atc gct tct gcc 259Val Ala Leu Ala Ser Gln Glu Glu Ile Asp Ala Thr Ile Ala Ser Ala

40 45 50acc aag gct gct aag acg tgg ggc aac ctg tct atc gct aag cgc caa 307Thr Lys Ala Ala Lys Thr Trp Gly Asn Leu Ser Ile Ala Lys Arg Gln

55 60 65gct gtg ctt ttc aac ttc cgt gag ctg ctg aat gct cgc aag ggt gag 355Ala Val Leu Phe Asn Phe Arg Glu Leu Leu Asn Ala Arg Lys Gly Glu 70 75 80 85ctg gcg gag atc atc act gca gag cac ggc aag gtc ttg tcc gat gcc 403Leu Ala Glu Ile Ile Thr Ala Glu His Gly Lys Val Leu Ser Asp Ala

90 95 100atg ggt gaa atc ctg cgc ggc cag gaa gtc gtg gag ctt gct acc ggt451Met Gly Glu Ile Leu Arg Gly Gln Glu Val Val Glu Leu Ala Thr Gly

105 110 115ttc cca cac ctg ctt aaa ggt gcg ttc aac gag aac gtc tcc acc ggc 499Phe Pro His Leu Leu Lys Gly Ala Phe Asn Glu Asn Val Ser Thr Gly

120 125 130att gat gtg tat tcc ttg aag cag cca ctg ggt gtt gtc ggt atc atc 547Ile Asp Val Tyr Ser Leu Lys Gln Pro Leu Gly Val Val Gly Ile Ile

135 140 145agc ccg ttc aac ttc cct gcg atg gtg ccg atg tgg ttt ttc cca atc 595Ser Pro Phe Asn Phe Pro Ala Met Val Pro Met Trp Phe Phe Pro Ile150 155 160 165gca atc gct gca ggc aac gca gtt att ttg aag cct tca gag aag gat 643Ala Ile Ala Ala Gly Asn Ala Val Ile Leu Lys Pro Ser Glu Lys Asp

170 175 180cct tcg gca gcg ctg tgg atg gct cag atc tgg aag gaa gct ggt ctt 691Pro Ser Ala Ala Leu Trp Met Ala Gln Ile Trp Lys Glu Ala Gly Leu

185 190 195cca gac ggc gta ttc aac gtg ctc cag ggc gac aag ctg gct gtt gat 739Pro Asp Gly Val Phe Asn Val Leu Gln Gly Asp Lys Leu Ala Val Asp

200 205 210ggt ttg ctg aac agc cct gat gtc tct gcg att tcc ttc gtg ggt tcc 787Gly Leu Leu Asn Ser Pro Asp Val Ser Ala Ile Ser Phe Val Gly Ser

215 220 225acc cca atc gca aag tac atc tac gag act tcc gcg aag aac ggc aag 835Thr Pro Ile Ala Lys Tyr Ile Tyr Glu Thr Ser Ala Lys Asn Gly Lys230 235 240 245cgc gtc cag gcg ttg ggc ggc gcg aag aac cac atg ctg gtg ctg cca 883Arg Val Gln Ala Leu Gly Gly Ala Lys Asn His Met Leu Val Leu Pro

250255 260gat gct gat ctg gat ctg gtt gcc gat cag gca atc aac gca ggt tac 931Asp Ala Asp Leu Asp Leu Val Ala Asp Gln Ala Ile Asn Ala Gly Tyr

265 270 275ggc gct gcc ggt gag cgt tgc atg gct gtt tct gtg gtc ttg gct att 979Gly Ala Ala Gly Glu Arg Cys Met Ala Val Ser Val Val Leu Ala Ile

280 285 290gaa tct gtt gcc gac gag ctc att gag aag atc aag gag cgc atc gac 1027Glu Ser Val Ala Asp Glu Leu Ile Glu Lys Ile Lys Glu Arg Ile Asp

295 300 305acc ctg cgc atc ggc aac ggt gcc ggc gac gag cag ggc gag ccg cac 1075Thr Leu Arg Ile Gly Asn Gly Ala Gly Asp Glu Gln Gly Glu Pro His310 315 320 325ctg ggc cca cta atc acc gac gtc cac cgc gac aag gtc gct tct tat 1123Leu GIy Pro Leu Ile Thr Asp Val His Arg Asp Lys Val Ala Ser Tyr

330 335 340gtc gac atc gct gag gcc gac ggc gcc aag atc atc gtg gac ggg cgt 1171Val Asp Ile Ala Glu Ala Asp Gly Ala Lys Ile Ile Val Asp Gly Arg

345 350 355aac tgc gcc gta gac ggg cac gag gag ggc ttc ttc ttc ggc cct acg 1219Asn Cys Ala Val Asp Gly His Glu Glu Gly Phe Phe Phe Gly Pro Thr

360 365 370ctt atc gac gac atc cca ctc acg ttc cgc gcc tac acc gaa gaa atc 1267Leu Ile Asp Asp Ile Pro Leu Thr Phe Arg Ala Tyr Thr Glu Glu Ile

375 380 385ttc ggc ccg gtc ctc tct gtc gtt cgt gtc gca tcc ttc gac gag gca 1315Phe Gly Pro Val Leu Ser Val Val Arg Val Ala Ser Phe Asp Glu Ala390 395 400 405att gag ctg atc aac tcc ggt gaa ttc ggc aac gga acc gca atc ttc 1363Ile Glu Leu Ile Asn Ser Gly Glu Phe Gly Asn Gly Thr Ala Ile Phe

410 415 420acc aac gat ggt gga gcg gca cgc cgc ttc cag cat gag atc gaa gtg 1411Thr Asn Asp Gly Gly Ala Ala Arg Arg Phe Gln His Glu Ile Glu Val

425 430 435ggc atg atc ggc atc aac gta cca atc cca gtg cct gtt gcg tac cac 1459Gly Met Ile Gly Ile Asn Val Pro Ile Pro Val Pro Val Ala Tyr His

440 445 450tcc ttc ggt ggt tgg aag aac tcc ctc ttc ggt gac gcc aag gca tat 1507Ser Phe Gly Gly Trp Lys Asn Ser Leu Phe Gly Asp Ala Lys Ala Tyr

455 460 465ggc act caa ggt ttt gat ttc ttc acc agg gaa aag gcg atc acc agc 1555Gly Thr Gln Gly Phe Asp Phe Phe Thr Arg Glu Lys Ala Ile Thr Ser470 475 480 485cgt tgg ctc gac cca gca acc cac ggt ggc att aac ctc ggt ttc cca 1603Arg Trp Leu Asp Pro Ala Thr His Gly Gly Ile Asn Leu Gly Phe Pro

490495500 cag aac gat taattgaagg agagcacagg act 1635Gln Asn Asp<210>222<211>504<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>222Met Ser Glu Pro Gln Thr Ile Ser His Trp Ile Asp Gly Ala Ile Ser 151015 Pro Ser Thr Ser Gly Lys Thr Ala Pro Val Tyr Asn Pro Ala Thr Gly

20 25 30Gln Val Thr Ala Asn Val Ala Leu Ala Ser Gln Glu Glu Ile Asp Ala

35 40 45Thr Ile Ala Ser Ala Thr Lys Ala Ala Lys Thr Trp Gly Asn Leu Ser

50 55 60Ile Ala Lys Arg Gln Ala Val Leu Phe Asn Phe Arg Glu Leu Leu Asn 65 70 75 80Ala Arg Lys Gly Glu Leu Ala Glu IleIle Thr Ala Glu His Gly Lys

85 90 95Val Leu Ser Asp Ala Met Gly Glu Ile Leu Arg Gly Gln Glu Val Val

100 105 110Glu Leu Ala Thr Gly Phe Pro His Leu Leu Lys Gly Ala Phe Asn Glu

115 120 125Asn Val Ser Thr Gly Ile Asp Val Tyr Ser Leu Lys Gln Pro Leu Gly

130 135 140Val Val Gly Ile Ile Ser Pro Phe Asn Phe Pro Ala Met Val Pro Met145 150 155 160Trp Phe Phe Pro Ile Ala Ile Ala Ala Gly Asn Ala Val Ile Leu Lys

165 170 175Pro Ser Glu Lys Asp Pro Ser Ala Ala Leu Trp Met Ala Gln Ile Trp

180 185 190Lys Glu Ala Gly Leu Pro Asp Gly Val Phe Asn Val Leu Gln Gly Asp

195 200 205Lys Leu Ala Val Asp Gly Leu Leu Asn Ser Pro Asp Val Ser Ala Ile

210 215 220Ser Phe Val Gly Ser Thr Pro Ile Ala Lys Tyr Ile Tyr Glu Thr Ser225 230 235 240Ala Lys Asn Gly Lys Arg Val Gln Ala Leu Gly Gly Ala Lys Asn His

245 250 255Met Leu Val Leu Pro Asp Ala Asp Leu Asp Leu Val Ala Asp Gln Ala

260 265 270Ile Asn Ala Gly Tyr Gly Ala Ala Gly Glu Arg Cys Met Ala Val Ser

275 280 285Val Val Leu Ala Ile Glu Ser Val Ala Asp Glu Leu Ile Glu Lys Ile

290 295 300Lys Glu Arg Ile Asp Thr Leu Arg Ile Gly Asn Gly Ala GlyAsp Glu305 310 315 320Gln Gly Glu Pro His Leu Gly Pro Leu Ile Thr Asp Val His Arg Asp

325 330 335Lys Val Ala Ser Tyr Val Asp Ile Ala Glu Ala Asp Gly Ala Lys Ile

340 345 350Ile Val Asp Gly Arg Asn Cys Ala Val Asp Gly His Glu Glu Gly Phe

355 360 365Phe Phe Gly Pro Thr Leu Ile Asp Asp Ile Pro Leu Thr Phe Arg Ala

370 375 380Tyr Thr Glu Glu Ile Phe Gly Pro Val Leu Ser Val Val Arg Val Ala385 390 395 400Ser Phe Asp Glu Ala Ile Glu Leu Ile Asn Ser Gly Glu Phe Gly Asn

405 410 415Gly Thr Ala Ile Phe Thr Asn Asp Gly Gly Ala Ala Arg Arg Phe Gln

420 425 430His Glu Ile Glu Val Gly Met Ile Gly Ile Asn Val Pro Ile Pro Val

435 440 445Pro Val Ala Tyr His Ser Phe Gly Gly Trp Lys Asn Ser Leu Phe Gly

450 455 460Asp Ala Lys Ala Tyr Gly Thr Gln Gly Phe Asp Phe Phe Thr Arg Glu465 470 475 480Lys Ala Ile Thr Ser Arg Trp Leu Asp Pro Ala Thr His Gly Gly Ile

485 490 495Asn Leu Gly Phe Pro Gln Asn Asp

500<210>223<211>1305<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1282)<223>RXA01260<400>223ctaaacgtgg gctgcattcc ttccaaagtc tctgatcaaa aacgctgaag ttgcccatac 60ctttacccat gagaagaaga ccttcggcat caatggcgaa gtg acc ttc aac tat 115

Val Thr Phe Asn Tyr

1 5gag gat gct cac aag cgt tcc cgt ggc gtt tcc gac aag atc gtt gga 163Glu Asp Ala His Lys Arg Ser Arg Gly Val Ser Asp Lys Ile Val Gly

10 15 20ggc gtt cat tac ttg atg aag aag aac aag atc atc gaa att cat ggt 211Gly Val His Tyr Leu Met Lys Lys Asn Lys Ile Ile Glu Ile His Gly

25 30 35ctt gga aac ttc aag gat gct aag act ctt gag gtc acc gac ggt aag 259Leu Gly Asn Phe Lys Asp Ala Lys Thr Leu Glu Val Thr Asp Gly Lys

40 45 50gat gct ggc aag acc atc acc ttt gat gac tgc atc atc gca acc ggt 307Asp Ala Gly Lys Thr Ile Thr Phe Asp Asp Cys Ile Ile Ala Thr Gly

55 60 65tcg gta gtc aac acc ctc cgt ggc gtt gac ttc tca gag aac gtt gtg 355Ser Val Val Asn Thr Leu Arg Gly Val Asp Phe Ser Glu Asn Val Val70 75 80 85tct ttt gaa gag cag att ctt aac cct gtt gcg cca aag aag atg gtc 403Ser Phe Glu Glu Gln Ile Leu Asn Pro Val Ala Pro Lys Lys Met Val

90 95 100att gtt ggt gca ggc gca att gga atg gaa ttc gcc tac gtt ctt ggt 451Ile Val Gly Ala Gly Ala Ile Gly Met Glu Phe Ala Tyr Val Leu Gly

105 110 115aac tac ggt gta gat gta acc gtc atc gag ttc atg gat cgt gtg ctt 499Asn Tyr Gly Val Asp Val Thr Val Ile Glu Phe Met Asp Arg Val Leu

120 125 130cca aat gaa gat gct gaa gtc tcc aag gtt att gca aag gcc tac aag 547Pro Asn Glu Asp Ala Glu Val Ser Lys Val Ile Ala Lys Ala Tyr Lys

135 140 145aag atg ggc gtt aag ctt ctt cct ggc cat gca acc act gct gtt cgg 595Lys Met Gly Val Lys Leu Leu Pro Gly His Ala Thr Thr Ala Val Arg150 155 160 165gac aac ggt gac ttt gtc gag gtt gat tac cag aag aag ggc tct gac 643Asp Asn Gly Asp Phe Val Glu Val Asp Tyr Gln Lys Lys Gly Ser Asp

170 175 180aag aca gag act ctt act gtt gat cga gtc atg gtt tcc gtt ggt ttc 691Lys Thr Glu Thr Leu Thr Val Asp Arg Val Met Val Ser Val Gly Phe

185 190 195cgt cca cgc gtt gag gga ttt ggt ctt gaa aac act ggc gtt aag ctc 739Arg Pro Arg Val Glu Gly Phe Gly Leu Glu Asn Thr Gly Val Lys Leu

200 205 210acc gag cgt ggc gca atc gag atc gat gat tac atg cgt acc aac gtc 787Thr Glu Arg Gly Ala Ile Glu Ile Asp Asp Tyr Met Arg Thr Asn Val

215 220 225gat ggc att tac gcc atc ggt gac gtg acc gcc aag ctt cag ctt gct 835Asp Gly Ile Tyr Ala Ile Gly Asp Val Thr Ala Lys Leu Gln Leu Ala230 235 240 245cac gtc gca gaa gca cag ggc att gtt gcc gca gag act att gct ggt 883His Val Ala Glu Ala Gln Gly Ile Val Ala Ala Glu Thr Ile Ala Gly

250 255 260gca gaa act cag act ctt ggt gat tac atg atg atg cca cgt gca acc 931Ala Glu Thr Gln Thr Leu Gly Asp Tyr Met Met Met Pro Arg Ala Thr

265 270 275ttc tgc aac cca cag gtt tct tcc ttt ggt tac acc gaa gag cag gcc 979Phe Cys Asn Pro Gln Val Ser Ser Phe Gly Tyr Thr Glu Glu Gln Ala

280 285290aag gag aag tgg cca gat cgt gag atc aag gtt gct tcc ttc cca ttc 1027Lys Glu Lys Trp Pro Asp Arg Glu Ile Lys Val Ala Ser Phe Pro Phe

295 300 305tct gca aac ggt aaa gca gtt ggc ctg gca gaa act gat ggt ttc gca 1075Ser Ala Asn Gly Lys Ala Val Gly Leu Ala Glu Thr Asp Gly Phe Ala310 315 320 325aag atc gtt gct gat gca gaa ttc ggt gag ctg ctc ggt gca cac ctg 1123Lys Ile Val Ala Asp Ala Glu Phe Gly Glu Leu Leu Gly Ala His Leu

330 335 340gtt gga gca aat gca tca gag ctc atc aat gaa ttg gtg ctt gct cag 1171Val Gly Ala Asn Ala Ser Glu Leu Ile Asn Glu Leu Val Leu Ala Gln

345 350 355aac tgg gat ctc acc act gaa gag atc tct cgt agc gtc cat att cac 1219Asn Trp Asp Leu Thr Thr Glu Glu Ile Ser Arg Ser Val His Ile His

360 365 370cca acg cta tct gag gca gtt aag gaa gct gca cac ggt atc tct gga 1267Pro Thr Leu Ser Glu Ala Val Lys Glu Ala Ala His Gly Ile Ser Gly

375380385 cac atg atc aac ttc tagaatccac ctcgttggcc ctg 1305His Met Ile Asn Phe390<210>224<211>394<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>224Val Thr Phe Asn Tyr Glu Asp Ala His Lys Arg Ser Arg Gly Val Ser 151015 Asp Lys Ile Val Gly Gly Val His Tyr Leu Met Lys Lys Asn Lys Ile

20 25 30Ile Glu Ile His Gly Leu Gly Asn Phe Lys Asp Ala Lys Thr Leu Glu

35 40 45Val Thr Asp Gly Lys Asp Ala Gly Lys Thr Ile Thr Phe Asp Asp Cys

50 55 60Ile Ile Ala Thr Gly Ser Val Val Asn Thr Leu Arg Gly Val Asp Phe 65 70 75 80Ser Glu Asn Val Val Ser Phe Glu Glu Gln Ile Leu Asn Pro Val Ala

85 90 95Pro Lys Lys Met Val Ile Val Gly Ala Gly Ala Ile Gly Met Glu Phe

100 105 110Ala Tyr Val Leu Gly Asn Tyr Gly Val Asp Val Thr Val Ile Glu Phe

115 120 125Met Asp Arg Val Leu Pro Asn Glu Asp Ala Glu Val Ser Lys Val Ile

130 135 140Ala Lys Ala Tyr Lys Lys Met Gly Val Lys Leu Leu Pro Gly His Ala145 150 155 160Thr Thr Ala Val Arg Asp Asn Gly Asp Phe Val Glu Val Asp Tyr Gln

165 170 175Lys Lys Gly Ser Asp Lys Thr Glu Thr Leu Thr Val Asp Arg Val Met

180 185 190Val Ser Val Gly Phe Arg Pro Arg Val Glu Gly Phe Gly Leu Glu Asn

195 200 205Thr Gly Val Lys Leu Thr Glu Arg Gly Ala Ile Glu Ile Asp Asp Tyr

210 215 220Met Arg Thr Asn Val Asp Gly Ile Tyr Ala Ile Gly Asp Val Thr Ala225 230 235 240Lys Leu Gln Leu Ala His Val Ala Glu Ala Gln Gly Ile Val Ala Ala

245 250 255Glu Thr Ile Ala Gly Ala Glu Thr Gln Thr Leu Gly Asp Tyr Met Met

260 265 270Met Pro Arg Ala Thr Phe Cys Asn Pro Gln Val Ser Ser Phe Gly Tyr

275 280 285Thr Glu Glu Gln Ala Lys Glu Lys Trp Pro Asp Arg Glu Ile Lys Val

290 295 300Ala Ser Phe Pro Phe Ser Ala Asn Gly Lys Ala Val Gly Leu Ala Glu305 310 315 320Thr Asp Gly Phe Ala Lys Ile Val Ala Asp Ala Glu Phe Gly Glu Leu

325 330 335Leu Gly Ala His Leu Val Gly Ala Asn Ala Ser Glu Leu Ile Asn Glu

340 345 350Leu Val Leu Ala Gln Asn Trp Asp Leu Thr Thr Glu Glu Ile Ser Arg

355 360 365Ser Val His Ile His Pro Thr Leu Ser Glu Ala Val Lys Glu Ala Ala

370375380 His Gly Ile Ser Gly His Met Ile Asn Phe 385390<210>225<211>294<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) · (271)<223>RXA01261<400>225gtgggtgttt ttcattttct tccactctaa aattaagtat ggaaaaccaa ccgcacccgg 60atgcacgaca atgacccact aaacacgtat ccttgaatgc gtg act gaa cat tat 115

Val Thr Glu His Tyr

1 5gac gta gta gta ctc gga gcc ggc ccc ggt ggc tat gtc tcc gcc atc 163Asp Val Val Val Leu Gly Ala Gly Pro Gly Gly Tyr Val Ser Ala Ile

10 15 20cgt gca gcg cag ctt ggc aag aag gtt gct gta att gag aag cag tac 211Arg Ala Ala Gln Leu Gly Lys Lys Val Ala Val Ile Glu Lys Gln Tyr

25 30 35tgg ggt ggt gtt tgc cta aac gtg ggc tgc att cct tcc aaa gtc tct 259Trp Gly Gly Val Cys Leu Asn Val Gly Cys Ile Pro Ser Lys Val Ser

40 45 50gat caa aaa cgc tgaagttgcc cataccttta ccc 294Asp Gln Lys Arg

55<210>226<211>57<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>226Val Thr Glu His Tyr Asp Val Val Val Leu Gly Ala Gly Pro Gly Gly 151015 Tyr Val Ser Ala Ile Arg Ala Ala Gln Leu Gly Lys Lys Val Ala Val

20 25 30Ile Glu Lys Gln Tyr Trp Gly Gly Val Cys Leu Asn Val Gly Cys Ile

35 40 45Pro Ser Lys Val Ser Asp Gln Lys Arg

5055<210>227<211>555<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (532)<223>RXA01136<400>227ccctcgcaac accgacggta gcctcttgga aatggcgcgc atcgtgcgtg agctttcccg 60ctaggacctg tctactgcct tcactttgtg cgaacaccgc atg acc ttg gat tac 115

Met Thr Leu Asp Tyr

1 5ttc aag gca tcc ggc act gac tat gct ttg gga ttg gct gca gag tcg 163Phe Lys Ala Ser Gly Thr Asp Tyr Ala Leu Gly Leu Ala Ala Glu Ser

10 15 20gaa ggg gca cga cgc act ggt atc acc ggc atg gcg agt gca ttc aag 211Glu Gly Ala Arg Arg Thr Gly Ile Thr Gly Met Ala Ser Ala Phe Lys

25 30 35gag ttt gct ggt tgt ggt gag atc gac ctt gaa gca acc agg gta gaa 259Glu Phe Ala Gly Cys Gly Glu Ile Asp Leu Glu Ala Thr Arg Val Glu

40 45 50ggt ggc ctc aaa gtt agt gga aag ctt cgt tgg gct tcc aac ttg tgc 307Gly Gly Leu Lys Val Ser Gly Lys Leu Arg Trp Ala Ser Asn Leu Cys

5560 65gaa gat cca gtg att gtg cct gct gca aag acc gca gag ggc tta caa 355Glu Asp Pro Val Ile Val Pro Ala Ala Lys Thr Ala Glu Gly Leu Gln 70 75 80 85cta ctg ttc gca ttg ggc gca gaa acc gaa ggt gtc acc ctc ggt tct 403Leu Leu Phe Ala Leu Gly Ala Glu Thr Glu Gly Val Thr Leu Gly Ser

90 95 100tca ctt gct cta ctc ggt ttg aac gca act gct tgc gct tgg gtg agc 451Ser Leu Ala Leu Leu Gly Leu Asn Ala Thr Ala Cys Ala Trp Val Ser

105 110 115ttt gag gat gtc ttc att cct ggg gct cag att cta agc cac gat ttc 499Phe Glu Asp Val Phe Ile Pro Gly Ala Gln Ile Leu Ser His Asp Phe

120 125 130ctt acc ttg tgg cat cgg tgc gcc caa cct tcg tgatcctacg gatctccgaa 552Leu Thr Leu Trp His Arg Cys Ala Gln Pro Ser

135140 tac 555<210>228<211>144<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>228Met Thr Leu Asp Tyr Phe Lys Ala Ser Gly Thr Asp Tyr Ala Leu Gly 151015 Leu Ala Ala Glu Ser Glu Gly Ala Arg Arg Thr Gly Ile Thr Gly Met

20 25 30Ala Ser Ala Phe Lys Glu Phe Ala Gly Cys Gly Glu Ile Asp Leu Glu

35 40 45Ala Thr Arg Val Glu Gly Gly Leu Lys Val Ser Gly Lys Leu Arg Trp

50 55 60Ala Ser Asn Leu Cys Glu Asp Pro Val Ile Val Pro Ala Ala Lys Thr 65 70 75 80Ala Glu Gly Leu Gln Leu Leu Phe Ala Leu Gly Ala Glu Thr Glu Gly

85 90 95Val Thr Leu Gly Ser Ser Leu Ala Leu Leu Gly Leu Asn Ala ThrAla

100 105 110Cys Ala Trp Val Ser Phe Glu Asp Val Phe Ile Pro Gly Ala Gln Ile

115 120 125Leu Ser His Asp Phe Leu Thr Leu Trp His Arg Cys Ala Gln Pro Ser

130135140<210>229<211>1140<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1117)<223>RXN00559<400>229cccttcaatc cagtctttga cggccaatac ggcttgccgg gtttccagcg gatcaatcct 60catgaagcat cagcctagta cgaaccgtta aagtgtccat atg tct gat aat ccg 115

Met Ser Asp Asn Pro

1 5cat gag aat ccc cgt gag aat cca cac cgc tcc cca gaa gtc gtc ctt 163His Glu Asn Pro Arg Glu Asn Pro His Arg Ser Pro Glu Val Val Leu

10 15 20cgt ttc atg gct gcc cct act gac gtt ttg atg gct ggt agc cat ggc 211Arg Phe Met Ala Ala Pro Thr Asp Val Leu Met Ala Gly Ser His Gly

25 30 35gtt ggc ggt ggc cga gtc ctg gaa tgg atc gat aag gct gct tat gct 259Val Gly Gly Gly Arg Val Leu Glu Trp Ile Asp Lys Ala Ala Tyr Ala

40 45 50tgt gct acc cag tgg tct gga acc tac tgt gtc act gct tat gtt ggt 307Cys Ala Thr Gln Trp Ser Gly Thr Tyr Cys Val Thr Ala Tyr Val Gly

55 60 65cac att cac ttc act cgc cct att ccc tct ggc cac atg gtc gag gtg 355His Ile His Phe Thr Arg Pro Ile Pro Ser Gly His Met Val Glu Val 70 75 80 85cgt tcc cgc att gcg atg act ggc cgt tcc tcc atg cac atc gtg aat 403Arg Ser Arg Ile Ala Met Thr Gly Arg Ser Ser Met His Ile Val Asn

90 95 100gag gtg ctt tct gcg gat cct cgc gat ggc aac tac acc cgt gcg tgt 451Glu Val Leu Ser Ala Asp Pro Arg Asp Gly Asn Tyr Thr Arg Ala Cys

105 110 115gac tgc ttg gtt att ttc gtg gcg aag gac acc gca act ggt cgc gct 499Asp Cys Leu Val Ile Phe Val Ala Lys Asp Thr Ala Thr Gly Arg Ala

120 125 130acc cca gtt cct tca ttt acc cct aag aat gaa gaa gag cag cgc gtg 547Thr Pro Val Pro Ser Phe Thr Pro Lys Asn Glu Glu Glu Gln Arg Val

135 140 145ttg gaa gct gct aac tcc cgc atc ggg ctg cgc aag gct att gaa gcg 595Leu Glu Ala Ala Asn Ser Arg Ile Gly Leu Arg Lys Ala Ile Glu Ala150 155 160 165gag atg gaa aag cag acg tac aac gga cct tct gag gcc cct cgt ttg 643Glu Met Glu Lys Gln Thr Tyr Asn Gly Pro Ser Glu Ala Pro Arg Leu

170 175 180att acc cgc ttc ttg gct aag cca aca gat atc aac tgg ggt ggc aag 691Ile Thr Arg Phe Leu Ala Lys Pro Thr Asp Ile Asn Trp Gly Gly Lys

185 190 195gtc cac ggt ggc act gcc atg gaa tgg atc gat gag gcg ggt gct gcg 739Val His Gly Gly Thr Ala Met Glu Trp Ile Asp Glu Ala Gly Ala Ala

200 205 210tgc acc atg gag tgg tct ggt aac cac acc gtt gcg gtt tat gct ggt 787Cys Thr Met Glu Trp Ser Gly Asn His Thr Val Ala Val Tyr Ala Gly

215 220 225ggt atc cgc ttc tac cag ccc att cag atc ggt gac ctc att gag gtg 835Gly Ile Arg Phe Tyr Gln Pro Ile Gln Ile Gly Asp Leu Ile Glu Val230 235 240 245gac gcccgc atg atg cgt acc gat aag cgt tcc atg cag atg tcc atc 883Asp Ala Arg Met Met Arg Thr Asp Lys Arg Ser Met Gln Met Ser Ile

250 255 260cac gtc cgt gcc ggt gat gct cac cgt ggc cgt gct gag cta gaa acc 931His Val Arg Ala Gly Asp Ala His Arg Gly Arg Ala Glu Leu Glu Thr

265 270 275gct att cac gca acg gtg acc tac tta gga att gat gtc gac gga gag 979Ala Ile His Ala Thr Val Thr Tyr Leu Gly Ile Asp Val Asp Gly Glu

280 285 290cct ttg cct gca cca cag ttt gtg cct cgt acc cct gag gat atc cag 1027Pro Leu Pro Ala Pro Gln Phe Val Pro Arg Thr Pro Glu Asp Ile Gln

295 300 305ttg gct gag cat gca aac atc ctg agg gat ctg cgt gct gat tac acc 1075Leu Ala Glu His Ala Asn Ile Leu Arg Asp Leu Arg Ala Asp Tyr Thr310 315 320 325cca atg ccg ctg ttc cag cgc agg gtt cca ctg cag atc gac 1117Pro Met Pro Leu Phe Gln Arg Arg Val Pro Leu Gln Ile Asp

330335 tagttagacc cgaaaaagcc ccc 1140<210>230<211>339<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>230Met Ser Asp Asn Pro His Glu Asn Pro Arg Glu Asn Pro His Arg Ser 151015 Pro Glu Val Val Leu Arg Phe Met Ala Ala Pro Thr Asp Val Leu Met

20 25 30Ala Gly Ser His Gly Val Gly Gly Gly Arg Val Leu Glu Trp Ile Asp

35 40 45Lys Ala Ala Tyr Ala Cys Ala Thr Gln Trp Ser Gly Thr Tyr Cys Val

50 55 60Thr Ala Tyr Val Gly His Ile His Phe Thr Arg Pro Ile Pro Ser Gly 65 70 75 80His Met Val Glu Val Arg Ser Arg Ile Ala Met Thr Gly Arg Ser Ser

85 90 95Met His Ile Val Asn Glu Val Leu Ser Ala Asp Pro Arg Asp Gly Asn

100 105 110Tyr Thr Arg Ala Cys Asp Cys Leu Val Ile Phe Val Ala Lys Asp Thr

115 120 125Ala Thr Gly Arg Ala Thr Pro Val Pro Ser Phe Thr Pro Lys Asn Glu

130 135 140Glu Glu Gln Arg Val Leu Glu Ala Ala Asn Ser Arg Ile Gly Leu Arg145 150 155 160Lys Ala Ile Glu Ala Glu Met Glu Lys Gln Thr Tyr Asn Gly Pro Ser

165 170 175Glu Ala Pro Arg Leu Ile Thr Arg Phe Leu Ala Lys Pro Thr Asp Ile

180 185 190Asn Trp Gly Gly Lys Val His Gly Gly Thr Ala Met Glu Trp Ile Asp

195 200 205Glu Ala Gly Ala Ala Cys Thr Met Glu Trp Ser Gly Asn His Thr Val

210 215 220Ala Val Tyr Ala Gly Gly Ile Arg Phe Tyr Gln Pro Ile Gln Ile Gly225 230 235 240Asp Leu Ile Glu Val Asp Ala Arg Met Met Arg Thr Asp Lys Arg Ser

245 250 255Met Gln Met Ser Ile His Val Arg Ala Gly Asp Ala His Arg Gly Arg

260 265 270Ala Glu Leu Glu Thr Ala Ile His Ala Thr Val Thr Tyr Leu Gly Ile

275 280 285Asp Val Asp Gly Glu Pro Leu Pro Ala Pro Gln Phe Val Pro Arg Thr

290 295300Pro Glu Asp Ile Gln Leu Ala Glu His Ala Asn Ile Leu Arg Asp Leu305 310 315 320Arg Ala Asp Tyr Thr Pro Met Pro Leu Phe Gln Arg Arg Val Pro Leu

325330335 Gln Ile Asp<210>231<211>313<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (313)<223>FRXA00559<400>231cccttcaatc cagtctttga cggccaatac ggcttgccgg gtttccagcg gatcaatcct 60catgaagcat cagcctagta cgaaccgtta aagtgtccat atg tct gat aat ccg 115

Met Ser Asp Asn Pro

1 5cat gag aat ccc cgt gag aat cca cac cgc tcc cca gaa gtc gtc ctt 163His Glu Asn Pro Arg Glu Asn Pro His Arg Ser Pro Glu Val Val Leu

10 15 20cgt ttc atg gct gcc cct act gac gtt ttg atg gct ggt agc cat ggc 211Arg Phe Met Ala Ala Pro Thr Asp Val Leu Met Ala Gly Ser His Gly

25 30 35gtt ggc ggt ggc cga gtc ctg gaa tgg atc gat aag gct gct tat gct 259Val Gly Gly Gly Arg Val Leu Glu Trp Ile Asp Lys Ala Ala Tyr Ala

40 45 50tgt gct acc cac ggg tct gga acc tac tgc gtc act gct tat gtt ggt 307Cys Ala Thr His Gly Ser Gly Thr Tyr Cys Val Thr Ala Tyr Val Gly

556065 cac att 313His 70<210>232<211>71<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>232Met Ser Asp Asn Pro His Glu Asn Pro Arg Glu Asn Pro His Arg Ser 151015 Pro Glu Val Val Leu Arg Phe Met Ala Ala Pro Thr Asp Val Leu Met

20 25 30Ala Gly Ser His Gly Val Gly Gly Gly Arg Val LeuGlu Trp Ile Asp

35 40 45Lys Ala Ala Tyr Ala Cys Ala Thr His Gly Ser Gly Thr Tyr Cys Val

505560 Thr Ala Tyr Val Gly His Ile 6570<210>233<211>802<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101) }, (802)<223>RXA01580<400>233cggtaaacgc ctcattaaag tccaatgcca tgctcataac actaacagtt aaccgtgcgg 60tcaactttgc tccctatcct taaaaagccc acagaaaagg atg tat aag aat atg 115

Met Tyr Lys Asn Met

1 5cac att gtt gcc cat cgc ggt gcg gaa gat ctg cac ctc gaa aac acc 163His Ile Val Ala His Arg Gly Ala Glu Asp Leu His Leu Glu Asn Thr

10 15 20atg acc gct ttc cag gct gcc gcg ccc gct gac gct ttt gag ctg gat 211Met Thr Ala Phe Gln Ala Ala Ala Pro Ala Asp Ala Phe Glu Leu Asp

25 30 35atc cac gcc acc gct gac aat cag gtc gtc gtt atc cac gac cgc acc 259Ile His Ala Thr Ala Asp Asn Gln Val Val Val Ile His Asp Arg Thr

40 45 50gca gcg cgt gtt gcc gcg cca gat tcc ctg cac cgc gac acc ccg gtt 307Ala Ala Arg Val Ala Ala Pro Asp Ser Leu His Arg Asp Thr Pro Val

55 60 65gcg cgc tta agc gcc gcg caa atc aag gag ata acg ctt atc gac gga 355Ala Arg Leu Ser Ala Ala Gln Ile Lys Glu Ile Thr Leu Ile Asp Gly 70 75 80 85tcc ccc gta cca acc ctg gag gaa gtt cta ctc cag acg agc ctg ccg 403Ser Pro Val Pro Thr Leu Glu Glu Val Leu Leu Gln Thr Ser Leu Pro

90 95100atc caa gtg gaa atc aaa tct gcc ggt gca gtt cca gca gcc gca gca 451Ile Gln Val Glu Ile Lys Ser Ala Gly Ala Val Pro Ala Ala Ala Ala

105 110 115tta ttg cag aaa tac cca gag cac ctg gag cgc ctg ctg ttc atc agt 499Leu Leu Gln Lys Tyr Pro Glu His Leu Glu Arg Leu Leu Phe Ile Ser

120 125 130ttc atc gat gca gca ctg gtg gaa atc gtg gat cga ctg cca gaa gct 547Phe Ile Asp Ala Ala Leu Val Glu Ile Val Asp Arg Leu Pro Glu Ala

135 140 145cgc gtg gga atc ttg cgc gat gcg tcc atg gat gat ctg cgc att ctt 595Arg Val Gly Ile Leu Arg Asp Ala Ser Met Asp Asp Leu Arg Ile Leu150 155 160 165gat tac atc ccg cta aaa aat gtg ggc gcg atc ttg ccc tcg tgg aaa 643Asp Tyr Ile Pro Leu Lys Asn Val Gly Ala Ile Leu Pro Ser Trp Lys

170 175 180gca cta aac gtg gcg tca att gct gat cta cat acc aag gga atc aag 691Ala Leu Asn Val Ala Ser Ile Ala Asp Leu His Thr Lys Gly Ile Lys

185 190 195gtt ggc tgc tgg aca att cgg gat gaa aat gcg ttt ggg atc gca caa 739Val Gly Cys Trp Thr Ile Arg Asp Glu Asn Ala Phe Gly Ile Ala Gln

200 205 210caa gct ggc gtt gat tac ccc act gtt agc gat ccc tct cgt ttc tcg 787Gln Ala Gly Val Asp Tyr Pro Thr Val Ser Asp Pro Ser Arg Phe Ser

215220225 cgc cct ccc ctg ctg 802Arg Pro Pro Leu Leu230<210>234<211>234<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>234Met Tyr Lys Asn Met His Ile Val Ala His Arg Gly Ala Glu Asp Leu 151015 His Leu Glu Asn Thr Met Thr Ala Phe Gln Ala Ala Ala Pro Ala Asp

20 25 30Ala Phe Glu Leu Asp Ile His Ala Thr Ala Asp Asn Gln Val Val Val

35 40 45Ile His Asp Arg Thr Ala Ala Arg Val Ala Ala Pro Asp Ser Leu His

50 55 60Arg Asp Thr Pro Val Ala Arg Leu Ser Ala Ala Gln Ile Lys Glu Ile 65 70 75 80Thr Leu Ile Asp Gly Ser Pro Val Pro Thr Leu Glu Glu Val Leu Leu

85 90 95Gln Thr Ser Leu Pro Ile Gln Val Glu Ile Lys Ser Ala Gly Ala Val

100 105 110Pro Ala Ala Ala Ala Leu Leu Gln Lys Tyr Pro Glu His Leu Glu Arg

115 120 125Leu Leu Phe Ile Ser Phe Ile Asp Ala Ala Leu Val Glu Ile Val Asp

130 135 140Arg Leu Pro Glu Ala Arg Val Gly Ile Leu Arg Asp Ala Ser Met Asp145 150 155 160Asp Leu Arg Ile Leu Asp Tyr Ile Pro Leu Lys Asn Val Gly Ala Ile

165 170 175Leu Pro Ser Trp Lys Ala Leu Asn Val Ala Ser Ile Ala Asp Leu His

180 185 190Thr Lys Gly Ile Lys Val Gly Cys Trp Thr Ile Arg Asp Glu Asn Ala

195 200 205Phe Gly Ile Ala Gln Gln Ala Gly Val Asp Tyr Pro Thr Val Ser Asp

210215220 Pro Ser Arg Phe Ser Arg Pro Pro Leu Leu 225230<210>235<211>882<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (859)<223>RXA02677<400>235ttagtgcagt gtatttattt ccgttcacgc tgcggggctg gtggtttgga gggatactag 60agtcgatagc aggtatataa aggccaggag agatgggttc atg aaa gtc atc gcg 115

Met Lys Val Ile Ala

1 5cac cga ggt tta tcg tct cgc ttt ccc gaa tta aca gag tct gcg ttt 163His Arg Gly Leu Ser Ser Arg Phe Pro Glu Leu Thr Glu Ser Ala Phe

10 15 20cgg gcg gct cta gag cta ccg att cat gga att gaa act gat gtc cgg 211Arg Ala Ala Leu Glu Leu Pro Ile His Gly Ile Glu Thr Asp Val Arg

25 30 35ctg act aaa tgt ggc gaa gtg gtt aac gtc cat gac ccc att gtg gat 259Leu Thr Lys Cys Gly Glu Val Val Asn Val His Asp Pro Ile Val Asp

40 45 50cgc gtg tcg aat ggt cgc ggt cgg gtg tcg cgt ttg gac ttg gaa tcc 307Arg Val Ser Asn Gly Arg Gly Arg Val Ser Arg Leu Asp Leu Glu Ser

55 60 65ttg ctg agc ttg aac ttt gga acc aaa gaa acc cca gaa aaa gtg ctt 355Leu Leu Ser Leu Asn Phe Gly Thr Lys Glu Thr Pro Glu Lys Val Leu 70 75 80 85act tta aac aat cta tta gat att ttt gag gat tat cca gat aag cac 403Thr Leu Asn Asn Leu Leu Asp Ile Phe Glu Asp Tyr Pro Asp Lys His

90 95 100ctt tat ata gaa acc aag cac cca atg cgc tac gcg gtc atg ctg gaa 451Leu Tyr Ile Glu Thr Lys His Pro Met Arg Tyr Ala Val Met Leu Glu

105 110 115gaa gaa atc aca aaa atc tta aaa tat cgt ggg ctg acg gaa gac cca 499Glu Glu Ile Thr Lys Ile Leu Lys Tyr Arg Gly Leu Thr Glu Asp Pro

120 125 130cgc atc cac atc att tct ttt gca ctt ccc gcg atg tat cgc atg gct 547Arg Ile His Ile Ile Ser Phe Ala Leu Pro Ala Met Tyr Arg Met Ala

135 140 145cgc ctt gct cca cag ctt gat cgc att cat ctg cgc agg tcg tgg gag 595Arg Leu Ala Pro Gln Leu Asp Arg Ile His Leu Arg Arg Ser Trp Glu150 155 160 165cgt tgg ggt aat ccg cgc gat gtg cgc tgc ggt gta ccc acc ggt ttg 643Arg Trp Gly Asn Pro Arg Asp Val Arg Cys Gly Val Pro Thr Gly Leu

170 175 180ggg ttg tcg ctg gag cgg gcg aag atg gat cca agg atg att ggg gcg 691Gly Leu Ser Leu Glu Arg Ala Lys Met Asp Pro Arg Met Ile Gly Ala

185 190 195aaa ggg tta ccc acc tat ctt ttc acc gtc gat aag caa aaa gac atg 739Lys Gly Leu Pro Thr Tyr Leu Phe Thr Val Asp Lys Gln Lys Asp Met

200 205 210ctg tgg gcg cgc gaa cag ggc gtc gac atg ctc gcc acc aat tat ccg 787Leu Trp Ala Arg Glu Gln Gly Val Asp Met Leu Ala Thr Asn Tyr Pro

215 220 225gac cgt gcg gcg gag ctt ttg aac gca cat ccc aag ccc gcc atg tac 835Asp Arg Ala Ala Glu Leu Leu Asn Ala His Pro Lys Pro Ala Met Tyr230 235 240 245gct aat gcg cat ggc aaa gaa gac taagaagaat gaacagctgc cgg 882Ala Asn Ala His Gly Lys Glu Asp

250<210>236<211>253<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>236Met Lys Val Ile Ala His Arg Gly Leu Ser Ser Arg Phe Pro Glu Leu 151015 Thr Glu Ser Ala Phe Arg Ala Ala Leu Glu Leu Pro Ile His Gly Ile

20 25 30Glu Thr Asp Val Arg Leu Thr Lys Cys Gly Glu Val Val Asn Val His

35 40 45Asp Pro Ile Val Asp Arg Val Ser Asn Gly Arg Gly Arg Val Ser Arg

50 55 60Leu Asp Leu Glu Ser Leu Leu Ser Leu Asn Phe Gly Thr Lys Glu Thr 65 70 75 80Pro Glu Lys Val Leu Thr Leu Asn Asn Leu Leu Asp Ile Phe Glu Asp

85 90 95Tyr Pro Asp Lys His Leu Tyr Ile Glu Thr Lys His Pro Met Arg Tyr

100 105 110Ala Val Met Leu Glu Glu Glu Ile Thr Lys Ile Leu Lys Tyr Arg Gly

115 120 125Leu Thr Glu Asp Pro Arg Ile His Ile Ile Ser Phe Ala Leu Pro Ala

130 135 140Met Tyr Arg Met Ala Arg Leu Ala Pro Gln Leu Asp Arg Ile His Leu145 150 155 160Arg Arg Ser Trp Glu Arg Trp Gly Asn Pro Arg Asp Val Arg Cys Gly

165 170 175Val Pro Thr Gly Leu Gly Leu Ser Leu Glu Arg Ala Lys Met Asp Pro

180 185 190Arg Met Ile Gly Ala Lys Gly Leu Pro Thr Tyr Leu Phe Thr Val Asp

195 200 205Lys Gln Lys Asp Met Leu Trp Ala Arg Glu Gln Gly Val Asp Met Leu

210 215 220Ala Thr Asn Tyr Pro Asp Arg Ala Ala Glu Leu Leu Asn Ala His Pro225 230 235 240Lys Pro Ala Met Tyr Ala Asn Ala His Gly Lys Glu Asp

245250<210>237<211>1428<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1405)<223>RXS01166<400>237accgtaccca cagacacacc agaattaaca gaaacagact gaaaaacaac atcgctcgac 60atgcgcgtaa tcctaacccg cgcacactaa tgtggccgat atg ggc tac acc aac 115

Met Gly Tyr Thr Asn

1 5ctc aac gac aca cgg gtc ttg cgc gcc ggg tca tgt gat gcc tgg tgg 163Leu Asn Asp Thr Arg Val Leu Arg Ala Gly Ser Cys Asp Ala Trp Trp

10 15 20cgc acg atg tct ccg cta gtg cag cag gga agt gag gca gtc ttt cgg 211Arg Thr Met Ser Pro Leu Val Gln Gln Gly Ser Glu Ala Val Phe Arg

25 30 35cgc atc atg ggt ctc tcg cgg cgt cct gat cgg aaa cct ggc ttt gac 259Arg Ile Met Gly Leu Ser Arg Arg Pro Asp Arg Lys Pro Gly Phe Asp

40 45 50gat gtc cca cat ttc ggc gca gct gtt cga gtt ccc ggt cta aaa cac 307Asp Val Pro His Phe Gly Ala Ala Val Arg Val Pro Gly Leu Lys His

55 60 65ggc acg ttg gtc aat gct gca ccc ttg aaa gtt ttg ggc gca cgg ggc 355Gly Thr Leu Val Asn Ala Ala Pro Leu Lys Val Leu Gly Ala Arg Gly 70 75 80 85gag ccc aac ccc gcg agt tcg tac cgt ttt gaa tac atc acc ggt gat 403Glu Pro Asn Pro Ala Ser Ser Tyr Arg Phe Glu Tyr Ile Thr Gly Asp

90 95 100tcc gca ggt cga gcc atc act gcg acc ggc gct gtc ctc ttt tcc aca 451Ser Ala Gly Arg Ala Ile Thr Ala Thr Gly Ala Val Leu Phe Ser Thr

105 110 115cgc ccc tgg aca acc ggc ccg cgt ccc gcg atc gcc atg gct cca tcc 499Arg Pro Trp Thr Thr Gly Pro Arg Pro Ala Ile Ala Met Ala Pro Ser

120 125 130acc caa ggc gtc gca cag cac tgc gat ccc tcc cac acc tgc gcc atc 547Thr Gln Gly Val Ala Gln His Cys Asp Pro Ser His Thr Cys Ala Ile

135 140 145gga ctc aac gca ttc tat gac aaa ccc ttc gac gca atc att gct tac 595Gly Leu Asn Ala Phe Tyr Asp Lys Pro Phe Asp Ala Ile Ile Ala Tyr150 155 160 165gaa ctc ccc gtc atc ctc tgg ttt cta gct cac gga ctt gac gtt gtg 643Glu Leu Pro Val Ile Leu Trp Phe Leu Ala His Gly Leu Asp Val Val

170 175 180ttc atc gat tac ccc cgc gac ccc gca acc ggc gtc caa tac tat tgc 691Phe Ile Asp Tyr Pro Arg Asp Pro Ala Thr Gly Val Gln Tyr Tyr Cys

185 190 195gat tcc atc gct gca gct aaa tcg ctt ctc gac gcc gtc ctc gcc tcc 739Asp Ser Ile Ala Ala Ala Lys Ser Leu Leu Asp Ala Val Leu Ala Ser

200 205 210aga caa ctc ggc ctt tca ccg gaa gca ccg ctt ggc ctg tgg gga ttc 787Arg Gln Leu Gly Leu Ser Pro Glu Ala Pro Leu Gly Leu Trp Gly Phe

215 220 225tcc caa gga ggc ggc gcc act ggc tgg gct gca caa ttg cag gat tac 835Ser Gln Gly Gly Gly Ala Thr Gly Trp Ala Ala Gln Leu Gln Asp Tyr230 235 240 245gca cct gat gtc cgc cca aag gca gcg gtc gtg ggc gct cca cca gtg 883Ala Pro Asp Val Arg Pro Lys Ala Ala Val Val Gly Ala Pro Pro Val

250 255 260gat ctc ttc cgc gtc ttg gac act gtc gac ggc gga ttg ctc acc gga 931Asp Leu Phe Arg Val Leu Asp Thr Val Asp Gly Gly Leu Leu Thr Gly

265 270 275gtg att gcc tac gcc atc gcg gga ctt gcagtg aac tct tca gag atg 979Val Ile Ala Tyr Ala Ile Ala Gly Leu Ala Val Asn Ser Ser Glu Met

280 285 290ttt gag gaa atc atg tcg gtg tta aat gaa cgc gga gtc agt gat gtg 1027Phe Glu Glu Ile Met Ser Val Leu Asn Glu Arg Gly Val Ser Asp Val

295 300 305ctg aaa aat atc acc agc tgc gcg gga ggt tcc ttg ttg gcc agt ggc 1075Leu Lys Asn Ile Thr Ser Cys Ala Gly Gly Ser Leu Leu Ala Ser Gly310 315 320 325tac tcg tct tcc cgc ggg tgg aca cat cag ggc acg ccg ctg gca gac 1123Tyr Ser Ser Ser Arg Gly Trp Thr His Gln Gly Thr Pro Leu Ala Asp

330 335 340att ctg gac gat ctg cca ctt gtt gtc gct gag ttt ggg aag caa aag 1171Ile Leu Asp Asp Leu Pro Leu Val Val Ala Glu Phe Gly Lys Gln Lys

345 350 355ctg ggt cgt gtg gcg cca gaa atc cca gtg ctg ttg tgg ggc tct aaa 1219Leu Gly Arg Val Ala Pro Glu Ile Pro Val Leu Leu Trp Gly Ser Lys

360 365 370aat gat gat gtc att ccc att gat ccc att agg gaa ttg cgt gat agc 1267Asn Asp Asp Val Ile Pro Ile Asp Pro Ile Arg Glu Leu Arg Asp Ser

375 380 385tgg gcg gac aag ggt acg cca ttg acc tgg cat gaa tcc caa gcg ccg 1315Trp Ala Asp Lys Gly Thr Pro Leu Thr Trp His Glu Ser Gln Ala Pro390 395 400 405cgt gtg cca gga cgc aca ggt ctc aac cat ttc ggg ccc tat ttt aga 1363Arg Val Pro Gly Arg Thr Gly Leu Asn His Phe Gly Pro Tyr Phe Arg

410 415 420aac ctg gaa aag tac tcg gga tgg ctc ata gat cat ctt gtc 1405Asn Leu Glu Lys Tyr Ser Gly Trp Leu Ile Asp His Leu Val

425430435 tgagtgccgt tttaaaggct cgg 1428<8>238<211>435<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>238Met Gly Tyr Thr Asn Leu Asn Asp Thr Arg Val Leu Arg Ala Gly Ser 151015 Cys Asp Ala Trp Trp Arg Thr Met Ser Pro Leu Val Gln Gln Gly Ser

20 25 30Glu Ala Val Phe Arg Arg Ile Met Gly Leu Ser Arg Arg Pro Asp Arg

35 40 45Lys Pro Gly Phe Asp Asp Val Pro His Phe Gly Ala Ala Val Arg Val

50 55 60Pro Gly Leu Lys His Gly Thr Leu Val Asn Ala Ala Pro Leu Lys Val 65 70 75 80Leu Gly Ala Arg Gly Glu Pro Asn Pro Ala Ser Ser Tyr Arg Phe Glu

85 90 95Tyr Ile Thr Gly Asp Ser Ala Gly Arg Ala Ile Thr Ala Thr Gly Ala

100 105 110Val Leu Phe Ser Thr Arg Pro Trp Thr Thr Gly Pro Arg Pro Ala Ile

115 120 125Ala Met Ala Pro Ser Thr Gln Gly Val Ala Gln His Cys Asp Pro Ser

130 135 140His Thr Cys Ala Ile Gly Leu Asn Ala Phe Tyr Asp Lys Pro Phe Asp145 150 155 160Ala Ile Ile Ala Tyr Glu Leu Pro Val Ile Leu Trp Phe Leu Ala His

165 170 175Gly Leu Asp Val Val Phe Ile Asp Tyr Pro Arg Asp Pro Ala Thr Gly

180 185 190Val Gln Tyr Tyr Cys Asp Ser Ile Ala Ala Ala Lys Ser Leu Leu Asp

195 200 205Ala Val Leu Ala Ser Arg Gln Leu Gly Leu Ser Pro Glu Ala Pro Leu

210 215 220Gly Leu Trp Gly Phe Ser Gln Gly Gly Gly Ala Thr Gly Trp Ala Ala225 230 235 240Gln Leu Gln Asp Tyr Ala Pro Asp Val Arg Pro Lys Ala Ala Val Val

245 250 255Gly Ala Pro Pro Val Asp Leu Phe Arg Val Leu Asp Thr Val Asp Gly

260 265 270Gly Leu Leu Thr Gly Val Ile Ala Tyr Ala Ile Ala Gly Leu Ala Val

275 280 285Asn Ser Ser Glu Met Phe Glu Glu Ile Met Ser Val Leu Asn Glu Arg

290 295 300Gly Val Ser Asp Val Leu Lys Asn Ile Thr Ser Cys Ala Gly Gly Ser305 310 315 320Leu Leu Ala Ser Gly Tyr Ser Ser Ser Arg Gly Trp Thr His Gln Gly

325 330 335Thr Pro Leu Ala Asp Ile Leu Asp Asp Leu Pro Leu Val Val Ala Glu

340 345 350Phe Gly Lys Gln Lys Leu Gly Arg Val Ala Pro Glu Ile Pro Val Leu

355 360 365Leu Trp Gly Ser Lys Asn Asp Asp Val Ile Pro Ile Asp Pro Ile Arg

370 375 380Glu Leu Arg Asp Ser Trp Ala Asp Lys Gly Thr Pro Leu Thr Trp His385 390 395 400Glu Ser Gln Ala Pro Arg Val Pro Gly Arg Thr Gly Leu Asn His Phe

405 410 415Gly Pro Tyr Phe Arg Asn Leu Glu Lys Tyr Ser Gly Trp Leu Ile Asp

420 425 430His Leu Val

435<210>239<211>690<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (667)<223>RXA00875<400>239caatttggcg gcgctgctgg gtgatcgggg gccggttgtt ccgggtgtga ttggtgactg 60ggtgaggggc taacgcaaca atgtgtctaa gcttaggggc atg act act gag gtt 115

Met Thr Thr Glu Val

1 5gaa ctg gtt gtt tta gct gat tcc gag ggc aat cct att ggt act gcg 163Glu Leu Val Val Leu Ala Asp Ser Glu Gly Asn Pro Ile Gly Thr Ala

10 15 20ccg aaa gct acg gtg cac act aag gac acg cct ctg cat ttc gcg ttt 211Pro Lys Ala Thr Val His Thr Lys Asp Thr Pro Leu His Phe Ala Phe

25 30 35tcc acc tat att ttg aac ccg cgt ggg gag ctg ttg gtg acg cgt cgt 259Ser Thr Tyr Ile Leu Asn Pro Arg Gly Glu Leu Leu Val Thr Arg Arg

40 45 50gca ttg tcg aag aag aca tgg cct ggt gtg tgg acg aac tct atg tgt 307Ala Leu Ser Lys Lys Thr Trp Pro Gly Val Trp Thr Asn Ser Met Cys

55 60 65ggg cac cct ggt ccg gat gag aca aac gcg gat gcg att cgt cgc agg 355Gly His Pro Gly Pro Asp Glu Thr Asn Ala Asp Ala Ile Arg Arg Arg 70 75 80 85ggt gtc gat gag ttg ggg ctg gag gta gat tct ttc ttg gat att caa 403Gly Val Asp Glu Leu Gly Leu Glu Val Asp Ser Phe Leu Asp Ile Gln

90 95 100gag att ctg cct gat tac cag tac cgt gct gtc gac gcg tcc ggc att 451Glu Ile Leu Pro Asp Tyr Gln Tyr Arg Ala Val Asp Ala Ser Gly Ile

105 110 115gtg gag tgg gag ttg tgc ccg gtc cacctc gtg cgt tta gcg gtg ggg 499Val Glu Trp Glu Leu Cys Pro Val His Leu Val Arg Leu Ala Val Gly

120 125 130gaa ttt gtg gag cca ctg gat gat gag gtg gag gag ttc gag tgg gcg 547Glu Phe Val Glu Pro Leu Asp Asp Glu Val Glu Glu Phe Glu Trp Ala

135 140 145gaa ccg cag aag ctt ttc gac gct gtt gat gcc aca cca ttt gtg ttt 595Glu Pro Gln Lys Leu Phe Asp Ala Val Asp Ala Thr Pro Phe Val Phe150 155 160 165tct cca tgg cta gtg gat cag ctt agc gcc cct gag ctg cgc caa gcc 643Ser Pro Trp Leu Val Asp Gln Leu Ser Ala Pro Glu Leu Arg Gln Ala

170 175 180atc ctg gaa gcg ttt gac gca gag taactaacta gtctagaagc ctt 690Ile Leu Glu Ala Phe Asp Ala Glu

185<210>240<211>189<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>240Met Thr Thr Glu Val Glu Leu Val Val Leu Ala Asp Ser Glu Gly Asn 151015 Pro Ile Gly Thr Ala Pro Lys Ala Thr Val His Thr Lys Asp Thr Pro

20 25 30Leu His Phe Ala Phe Ser Thr Tyr Ile Leu Asn Pro Arg Gly Glu Leu

35 40 45Leu Val Thr Arg Arg Ala Leu Ser Lys Lys Thr Trp Pro Gly Val Trp

50 55 60Thr Asn Ser Met Cys Gly His Pro Gly Pro Asp Glu Thr Asn Ala Asp 65 70 75 80Ala Ile Arg Arg Arg Gly Val Asp Glu Leu Gly Leu Glu Val Asp Ser

85 90 95Phe Leu Asp Ile Gln Glu Ile Leu Pro Asp Tyr Gln Tyr Arg Ala Val

100 105 110Asp AlaSer Gly Ile Val Glu Trp Glu Leu Cys Pro Val His Leu Val

115 120 125Arg Leu Ala Val Gly Glu Phe Val Glu Pro Leu Asp Asp Glu Val Glu

130 135 140Glu Phe Glu Trp Ala Glu Pro Gln Lys Leu Phe Asp Ala Val Asp Ala145 150 155 160Thr Pro Phe Val Phe Ser Pro Trp Leu Val Asp Gln Leu Ser Ala Pro

165 170 175Glu Leu Arg Gln Ala Ile Leu Glu Ala Phe Asp Ala Glu

180185<210>241<211>1308<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1285)<223>RXA01292<400>241tccgcgtccc tcgaagactt aaaaaacggg cgggattttg tgccgtcttt aaaaaagcca 60gcctggcaac caaagcaatg tggaaagaag tgtttcaaaa atg aca aaa gca gtg 115

Met Thr Lys Ala Val

1 5gtc atc ggc ggg gga cta gca gga cta gcc acc acc gca ctg ctc tta 163Val Ile Gly Gly Gly Leu Ala Gly Leu Ala Thr Thr Ala Leu Leu Leu

10 15 20cgc gaa gga tat gaa gtc cac ctc gtc gaa caa aac gag cac ctc ggc 211Arg Glu Gly Tyr Glu Val His Leu Val Glu Gln Asn Glu His Leu Gly

25 30 35ggc cgc gcc ggg acc ttc gaa ctc gac ggc ttc cgc tgg gac acc ggc 259Gly Arg Ala Gly Thr Phe Glu Leu Asp Gly Phe Arg Trp Asp Thr Gly

40 45 50ccc agc tgg tac ctc atg ccc gac gcc atg tcc cac ttc ttt aag ctc 307Pro Ser Trp Tyr Leu Met Pro Asp Ala Met Ser His Phe Phe Lys Leu

55 6065tgc ggc acc tcc atc gac gac cac ctc gac ctc gtg cca ctt gaa ccc 355Cys Gly Thr Ser Ile Asp Asp His Leu Asp Leu Val Pro Leu Glu Pro 70 75 80 85gcc tac cgc gtc atc gac gac cac ggc gaa ttc atc gac gtc acc tcc 403Ala Tyr Arg Val Ile Asp Asp His Gly Glu Phe Ile Asp Val Thr Ser

90 95 100gac atc gat gcg atg gcc gag ctt ttc gaa tcc cgc gaa ccc ggc gcc 451Asp Ile Asp Ala Met Ala Glu Leu Phe Glu Ser Arg Glu Pro Gly Ala

105 110 115ggc gcc aaa ctg cgc acc tat atc gac tcc gcc aca cag gtc tac aac 499Gly Ala Lys Leu Arg Thr Tyr Ile Asp Ser Ala Thr Gln Val Tyr Asn

120 125 130ctg gcc atc gac ggc ttc ctc tac acc aac ttc acc aac ttc atc cca 547Leu Ala Ile Asp Gly Phe Leu Tyr Thr Asn Phe Thr Asn Phe Ile Pro

135 140 145tac tta agc ccc ggc atg ctg cgc ctt tta ccc aaa ctt cta gca agc 595Tyr Leu Ser Pro Gly Met Leu Arg Leu Leu Pro Lys Leu Leu Ala Ser150 155 160 165ctg tcg acc tcg cta aaa gtc aag gtc aac acc caa ttc cgc gat aca 643Leu Ser Thr Ser Leu Lys Val Lys Val Asn Thr Gln Phe Arg Asp Thr

170 175 180aaa ctg cgc caa atc tta agc tac ccc gca gtt ttc ctc tcc tca gac 691Lys Leu Arg Gln Ile Leu Ser Tyr Pro Ala Val Phe Leu Ser Ser Asp

185 190 195cct tcg cac acc ccg gcg ctc tat cac ctc atg agc cac acc gac ctc 739Pro Ser His Thr Pro Ala Leu Tyr His Leu Met Ser His Thr Asp Leu

200 205 210gtc caa ggc gtc tcc tat ccc cga ggc ggc ttc acc gcc ttc atc aag 787Val Gln Gly Val Ser Tyr Pro Arg Gly Gly Phe Thr Ala Phe Ile Lys

215 220 225gca cta att tcg ctt atc gac gac gcc gtc ctc cac ctc ggc acc ccc 835Ala Leu Ile Ser Leu Ile Asp Asp Ala Val Leu His Leu Gly Thr Pro230 235 240 245gtc agc gca atc acc acc caa ggc cga aac gcc aca ggc gtc caa gtc 883Val Ser Ala Ile Thr Thr Gln Gly Arg Asn Ala Thr Gly Val Gln Val

250 255 260ggc tca gag ttc atc gaa gcc gat atc gtg atc agc tgc gct gat cag 931Gly Ser Glu Phe Ile Glu Ala Asp Ile Val Ile Ser Cys Ala Asp Gln

265 270 275cac cac acc gaa acc caa ctc cta cct gct tcg ttg tgc gcg aag ccg 979His His Thr Glu Thr Gln Leu Leu Pro Ala Ser Leu Cys Ala Lys Pro

280 285 290gag acg agc tgg aag aac aaa caa ccc ggc ctc agt act gtg ctg gtt 1027Glu Thr Ser Trp Lys Asn Lys Gln Pro Gly Leu Ser Thr Val Leu Val

295 300 305ttg gca ggc gtg aag ggg gag cac acc ctg ctt ttt cct ccg act ggg 1075Leu Ala Gly Val Lys Gly Glu His Thr Leu Leu Phe Pro Pro Thr Gly310 315 320 325acg aag att tcc gca aag ttt tcg acg gct cca ccc cag aat tcc cgg 1123Thr Lys Ile Ser Ala Lys Phe Ser Thr Ala Pro Pro Gln Asn Ser Arg

330 335 340ctt cag aat cca tct aga tct cca aga cct ccg caa cag att ccg atg 1171Leu Gln Asn Pro Ser Arg Ser Pro Arg Pro Pro Gln Gln Ile Pro Met

345 350 355ccg cac ccg aag gcc acg aga acc tct tca tcc tgg tcc cag tac ccg 1219Pro His Pro Lys Ala Thr Arg Thr Ser Ser Ser Trp Ser Gln Tyr Pro

360 365 370ccg atg tct cca ttg gtc acg ggt ccg ctt acg gag aag aat ctg aca 1267Pro Met Ser Pro Leu Val Thr Gly Pro Leu Thr Glu Lys Asn Leu Thr

375380385 tgg tgg gcc gga tcg caa tagcagcagt ggctcaaatt ggg 1308Trp Trp Ala Gly Ser Gln 390395<210>242<211>395<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>242Met Thr Lys Ala Val Val Ile Gly Gly Gly Leu Ala Gly Leu Ala Thr 151015 Thr Ala Leu Leu Leu Arg Glu Gly Tyr Glu Val His Leu Val Glu Gln

20 25 30Asn Glu His Leu Gly Gly Arg Ala Gly Thr Phe Glu Leu Asp Gly Phe

35 40 45Arg Trp Asp Thr Gly Pro Ser Trp Tyr Leu Met Pro Asp Ala Met Ser

50 55 60His Phe Phe Lys Leu Cys Gly Thr Ser Ile Asp Asp His Leu Asp Leu 65 70 75 80Val Pro Leu Glu Pro Ala Tyr Arg Val Ile Asp Asp His Gly Glu Phe

85 90 95Ile Asp Val Thr Ser Asp Ile Asp Ala Met Ala Glu Leu Phe Glu Ser

100 105 110Arg Glu Pro Gly Ala Gly Ala Lys Leu Arg Thr Tyr Ile Asp Ser Ala

115 120 125Thr Gln Val Tyr Asn Leu Ala Ile Asp Gly Phe Leu Tyr Thr Asn Phe

130 135 140Thr Asn Phe Ile Pro Tyr Leu Ser Pro Gly Met Leu Arg Leu Leu Pro145 150 155 160Lys Leu Leu Ala Ser Leu Ser Thr Ser Leu Lys Val Lys Val Asn Thr

165 170 175Gln Phe Arg Asp Thr Lys Leu Arg Gln Ile Leu Ser Tyr Pro Ala Val

180185 190Phe Leu Ser Ser Asp Pro Ser His Thr Pro Ala Leu Tyr His Leu Met

195 200 205Ser His Thr Asp Leu Val Gln Gly Val Ser Tyr Pro Arg Gly Gly Phe

210 215 220Thr Ala Phe Ile Lys Ala Leu Ile Ser Leu Ile Asp Asp Ala Val Leu225 230 235 240His Leu Gly Thr Pro Val Ser Ala Ile Thr Thr Gln Gly Arg Asn Ala

245 250 255Thr Gly Val Gln Val Gly Ser Glu Phe Ile Glu Ala Asp Ile Val Ile

260 265 270Ser Cys Ala Asp Gln His His Thr Glu Thr Gln Leu Leu Pro Ala Ser

275 280 285Leu Cys Ala Lys Pro Glu Thr Ser Trp Lys Asn Lys Gln Pro Gly Leu

290 295 300Ser Thr Val Leu Val Leu Ala Gly Val Lys Gly Glu His Thr Leu Leu305 310 315 320Phe Pro Pro Thr Gly Thr Lys Ile Ser Ala Lys Phe Ser Thr Ala Pro

325 330 335Pro Gln Asn Ser Arg Leu Gln Asn Pro Ser Arg Ser Pro Arg Pro Pro

340 345 350Gln Gln Ile Pro Met Pro His Pro Lys Ala Thr Arg Thr Ser Ser Ser

355 360 365Trp Ser Gln Tyr Pro Pro Met Ser Pro Leu Val Thr Gly Pro Leu Thr

370375380 Glu Lys Asn Leu Thr Trp Trp Ala Gly Ser Gln 385390395<210>243<211>450<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><22I>CDS<222>(101) · (427)<223>RXA01293<400>243cgatgccgca cccgaaggcc acgagaacct cttcatcctg gtcccagtac ccgccgatgt 60ctccattggt cacgggtccg cttacggaga agaatctgac atg gtg ggc cgg atc 115

Met Val Gly Arg Ile

1 5gca ata gca gca gtg gct caa att ggg cga tgg gct ggc att gat ggt 163Ala Ile Ala Ala Val Ala Gln Ile Gly Arg Trp Ala Gly Ile Asp Gly

10 15 20ttg gaa agc cgc att gtt gtg cag cgc acc atc ggc cct gcc gac ttc 211Leu Glu Ser Arg Ile Val Val Gln Arg Thr Ile Gly Pro Ala Asp Phe

25 30 35gca gac cga tac aac tcc tgg agc ggc ggg tcc att ggc ccc tca cac 259Ala Asp Arg Tyr Asn Ser Trp Ser Gly Gly Ser Ile Gly Pro Ser His

40 45 50acc ctg gca caa tcg gcg ttc ttt agg ggt tct aac aaa tcc cgc aaa 307Thr Leu Ala Gln Ser Ala Phe Phe Arg Gly Ser Asn Lys Ser Arg Lys

55 60 65gta gat ggc ctg tat gac gca ggt gac acc aca gtt cca ggg gtg ggc 355Val Asp Gly Leu Tyr Asp Ala Gly Asp Thr Thr Val Pro Gly Val Gly 70 75 80 85gta tct atg tgt ttg atc tct gca gaa aac gtg ctc aag cgt ctc cgc 403Val Ser Met Cys Leu Ile Ser Ala Glu Asn Val Leu Lys Arg Leu Arg

90 95 100ggg gac aac agt gtg gat cgg act taacgggact tttttctttt gct 450Gly Asp Asn Ser Val Asp Arg Thr

105<210>244<211>109<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>244Met Val Gly Arg Ile Ala Ile Ala Ala Val Ala Gln Ile Gly Arg Trp 151015 Ala Gly Ile Asp Gly Leu Glu Ser Arg Ile Val Val Gln Arg Thr Ile

20 2530Gly Pro Ala Asp Phe Ala Asp Arg Tyr Asn Ser Trp Ser Gly Gly Ser

35 40 45Ile Gly Pro Ser His Thr Leu Ala Gln Ser Ala Phe Phe Arg Gly Ser

50 55 60Asn Lys Ser Arg Lys Val Asp Gly Leu Tyr Asp Ala Gly Asp Thr Thr 65 70 75 80Val Pro Gly Val Gly Val Ser Met Cys Leu Ile Ser Ala Glu Asn Val

85 90 95Leu Lys Arg Leu Arg Gly As p Asn Ser Val Asp Arg Thr

100105<210>245<211>1386<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1363)<223>RXA02310<400>245gaaatggaca aaaagctttt tgtttaaccg tagtcgacgg aaggcacttg aagcaccttg 60ggttagtctt cttgctctcc ggactgagac aatggggttt gtg tct aca act ttt 115

Val Ser Thr Thr Phe

1 5gat gtg ttg atc atc ggc gcg ggc ccc tca ggt gcc agc gcc gcc gtc 163Asp Val Leu Ile Ile Gly Ala Gly Pro Ser Gly Ala Ser Ala Ala Val

10 15 20cat gcg gcc agg act ggg ctt caa aca ttg ctt atc gac gcc tcc tcc 211His Ala Ala Arg Thr Gly Leu Gln Thr Leu Leu Ile Asp Ala Ser Ser

25 30 35ttc ccg cgg gat aaa acg tgt ggc gat ggc ctt act ccc cgt gcg att 259Phe Pro Arg Asp Lys Thr Cys Gly Asp Gly Leu Thr Pro Arg Ala Ile

40 45 50cac cag cta gaa ctt cta ggt gtt gct gat cag gtt acc ggg gat tat 307His Gln Leu Glu Leu Leu Gly Val Ala Asp Gln Val Thr Gly Asp Tyr

55 60 65ttc aac aag ggc ttg aaa ctg cat ggt ttt ggt ggc tct gtt gag gcg 355Phe Asn Lys Gly Leu Lys Leu His Gly Phe Gly Gly Ser Val Glu Ala 70 75 80 85ccg tgg ccg gag aca tat ttc acg aat aag ggt tcc gcg atg tcg cgg 403Pro Trp Pro Glu Thr Tyr Phe Thr Asn Lys Gly Ser Ala Met Ser Arg

90 95 100atg gag ttc gat gat ttg tta ttc cgc ttg gca aaa tct cat gag gaa 451Met Glu Phe Asp Asp Leu Leu Phe Arg Leu Ala Lys Ser His Glu Glu

105 110 115gta acc acg tgg gag aac gcg agc gcc caa gac ccc att ttg agg ggg 499Val Thr Thr Trp Glu Asn Ala Ser Ala Gln Asp Pro Ile Leu Arg Gly

120 125 130aat ttc ttg gaa ggc gtt gtg att aat cac gca ggg caa gag aaa acc 547Asn Phe Leu Glu Gly Val Val Ile Asn His Ala Gly Gln Glu Lys Thr

135 140 145gtc aag gcg aag cat gtg att att gcc gat ggt gtc cgc tcc cct ttc 595Val Lys Ala Lys His Val Ile Ile Ala Asp Gly Val Arg Ser Pro Phe150 155 160 165ggt aag aaa ctg ggt agg cag tgg caa cgc gat gag gtg tat ggc att 643Gly Lys Lys Leu Gly Arg Gln Trp Gln Arg Asp Glu Val Tyr Gly Ile

170 175 180gcg gct cgt gct tat tgt gaa act ccg ctg tct gat gaa ccg tgg att 691Ala Ala Arg Ala Tyr Cys Glu Thr Pro Leu Ser Asp Glu Pro Trp Ile

185 190 195cac tcc cat gtg gaa ctg cgc gat gaa gat ggt gtg gtg cag cca gga 739His Ser His Val Glu Leu Arg Asp Glu Asp Gly Val Val Gln Pro Gly

200 205 210tat ggg tgg att ttc ccg ctg ggc aac ggc acg gtg aat ttgggt tgt 787Tyr Gly Trp Ile Phe Pro Leu Gly Asn Gly Thr Val Asn Leu Gly Cys

215 220 225ggc gcg ctc tcg acg gat acg aga cca gcg aag atc aat acg aag aaa 835Gly Ala Leu Ser Thr Asp Thr Arg Pro Ala Lys Ile Asn Thr Lys Lys230 235 240 245ttg ttg agc ttc tat gcg ggt cag cgt cgt aaa gca tgg caa ctc ggg 883Leu Leu Ser Phe Tyr Ala Gly Gln Arg Arg Lys Ala Trp Gln Leu Gly

250 255 260ccc gag cac gac gtc gcc tct gcc ctg ctg cct atg ggc ggc gcg gtg 931Pro Glu His Asp Val Ala Ser Ala Leu Leu Pro Met Gly Gly Ala Val

265 270 275tcg aat gtg gct ggc gcg aac tgg atg ctg atc ggc gat tcc gcc gcg 979Ser Asn Val Ala Gly Ala Asn Trp Met Leu Ile Gly Asp Ser Ala Ala

280 285 290tgt gtg aac ccg ctg aac ggc gaa ggc atc gac tat ggc ctg gaa acc 1027Cys Val Asn Pro Leu Asn Gly Glu Gly Ile Asp Tyr Gly Leu Glu Thr

295 300 305gcg gcg atg gcc gtc gac acg ctt gtg gaa aac ccc aag cgc gat ttg 1075Ala Ala Met Ala Val Asp Thr Leu Val Glu Asn Pro Lys Arg Asp Leu310 315 320 325acc ttg gta tgg cca cat agg ttg cgc gac gcg tac ggc gag acc ttc 1123Thr Leu Val Trp Pro His Arg Leu Arg Asp Ala Tyr Gly Glu Thr Phe

330 335 340atg ttg gcg cgc acg gct gct cga ctg ctg acg tac ccg cag ttt ttg 1171Met Leu Ala Arg Thr Ala Ala Arg Leu Leu Thr Tyr Pro Gln Phe Leu

345 350 355ccg atg gct ggg ccg ctc gca ttc cgc ggg ccg ctg caa aag gcc atc 1219Pro Met Ala Gly Pro Leu Ala Phe Arg Gly Pro Leu Gln Lys Ala Ile

360 365 370atg ccg gcg gct gcg cgt ttg atg ggc aac ctg atc aca gag gag gat 1267Met Pro Ala Ala Ala Arg Leu Met Gly Asn Leu Ile Thr Glu Glu Asp

375 380 385aaa gac ctg ctc gcc agg ggt tgg cag gcc gcc gga tcc gcg att agt 1315Lys Asp Leu Leu Ala Arg Gly Trp Gln Ala Ala Gly Ser Ala Ile Ser390 395 400 405tgg gcg cgg aag ggc tcc cct ctg tgg gac tcg act agt tct ctg gtt 1363Trp Ala Arg Lys Gly Ser Pro Leu Trp Asp Ser Thr Ser Ser Leu Val

410415420 taatcgccga gtgcagcgcg acg 1386<210>246<211>421<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>246Val Ser Thr Thr Phe Asp Val Leu Ile Ile Gly Ala Gly Pro Ser Gly 151015 Ala Ser Ala Ala Val His Ala Ala Arg Thr Gly Leu Gln Thr Leu Leu

20 25 30Ile Asp Ala Ser Ser Phe Pro Arg Asp Lys Thr Cys Gly Asp Gly Leu

35 40 45Thr Pro Arg Ala Ile His Gln Leu Glu Leu Leu Gly Val Ala Asp Gln

50 55 60Val Thr Gly Asp Tyr Phe Asn Lys Gly Leu Lys Leu His Gly Phe Gly 65 70 75 80Gly Ser Val Glu Ala Pro Trp Pro Glu Thr Tyr Phe Thr Asn Lys Gly

85 90 95Ser Ala Met Ser Arg Met Glu Phe Asp Asp Leu Leu Phe Arg Leu Ala

100 105 110Lys Ser His Glu Glu Val Thr Thr Trp Glu Asn Ala Ser Ala Gln Asp

115 120 125Pro Ile Leu Arg Gly Asn Phe Leu Glu Gly Val Val Ile Asn His Ala

130 135 140Gly Gln Glu Lys Thr Val Lys Ala Lys His Val Ile Ile Ala Asp Gly145 150 155 160Val Arg Ser Pro Phe Gly Lys Lys Leu Gly Arg Gln Trp Gln Arg Asp

165 170 175Glu Val Tyr Gly Ile Ala Ala Arg Ala Tyr Cys Glu Thr Pro Leu Ser

180 185 190Asp Glu Pro Trp Ile His Ser His Val Glu Leu Arg Asp Glu Asp Gly

195 200 205Val Val Gln Pro Gly Tyr Gly Trp Ile Phe Pro Leu Gly Asn Gly Thr

210 215 220Val Asn Leu Gly Cys Gly Ala Leu Ser Thr Asp Thr Arg Pro Ala Lys225 230 235 240Ile Asn Thr Lys Lys Leu Leu Ser Phe Tyr Ala Gly Gln Arg Arg Lys

245 250 255Ala Trp Gln Leu Gly Pro Glu His Asp Val Ala Ser Ala Leu Leu Pro

260 265 270Met Gly Gly Ala Val Ser Asn Val Ala Gly Ala Asn Trp Met Leu Ile

275 280 285Gly Asp Ser Ala Ala Cys Val Asn Pro Leu Asn Gly Glu Gly Ile Asp

290 295 300Tyr Gly Leu Glu Thr Ala Ala Met Ala Val Asp Thr Leu Val Glu Asn305 310 315 320Pro Lys Arg Asp Leu Thr Leu Val Trp Pro His Arg Leu Arg Asp Ala

325 330 335Tyr Gly Glu Thr Phe Met Leu Ala Arg Thr Ala Ala Arg Leu Leu Thr

340 345 350Tyr Pro Gln Phe Leu Pro Met Ala Gly Pro Leu Ala Phe Arg Gly Pro

355 360 365Leu Gln Lys Ala Ile Met Pro Ala AlaAla Arg Leu Met Gly Asn Leu

370 375 380Ile Thr Glu Glu Asp Lys Asp Leu Leu Ala Arg Gly Trp Gln Ala Ala385 390 395 400Gly Ser Ala Ile Ser Trp Ala Arg Lys Gly Ser Pro Leu Trp Asp Ser

405 410 415Thr Ser Ser Leu Val

420<210>247<211>1170<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1147)<223>RXA02718<400>247tccaccaaaa ttcagcccgc atccccctat tcgattgaag gacgtctcct tgagcagttt 60cgatgcccat gaccttgacc tcgacaaatt tccggaggtc gtg cga gat cgt ttg 115

Val Arg Asp Arg Leu

1 5acg cag ttc ctc gat gct caa gag cta aca att gct gat atc ggc gct 163Thr Gln Phe Leu Asp Ala Gln Glu Leu Thr Ile Ala Asp Ile Gly Ala

10 15 20cct gtc aca gat gct gtg gcc cat ctt cgc agt ttc gtg ctc aat gga 211Pro Val Thr Asp Ala Val Ala His Leu Arg Ser Phe Val Leu Asn Gly

25 30 35gga aag cga atc cgt cct ctt tat gcg tgg gct ggt ttc ctg gcg gcg 259Gly Lys Arg Ile Arg Pro Leu Tyr Ala Trp Ala Gly Phe Leu Ala Ala

40 45 50caa ggc cat aag aat tct tct gaa aaa ctt gag tcc gtc ctt gac gcc 307Gln Gly His Lys Asn Ser Ser Glu Lys Leu Glu Ser Val Leu Asp Ala

55 60 65gca gcg agt ctc gaa ttc atc cag gct tgt gcc ttg att cat gac gat 355Ala Ala Ser Leu Glu Phe Ile Gln Ala Cys Ala Leu Ile His Asp Asp 70 75 8085att atc gat tct tct gat acc cgg cgc gga gcc ccc aca gtt cac cgg 403Ile Ile Asp Ser Ser Asp Thr Arg Arg Gly Ala Pro Thr Val His Arg

90 95 100gct gtg gaa gct gat cac cgc gcc aat aat ttc gaa ggc gat ccc gag 451Ala Val Glu Ala Asp His Arg Ala Asn Asn Phe Glu Gly Asp Pro Glu

105 110 115cac ttt ggc gtt tca gtc tcg att ttg gct ggc gat atg gca ttg gtg 499His Phe Gly Val Ser Val Ser Ile Leu Ala Gly Asp Met Ala Leu Val

120 125 130tgg gca gaa gac atg ctg cag gat tcc ggt ttg agt gca gag gca ttg 547Trp Ala Glu Asp Met Leu Gln Asp Ser Gly Leu Ser Ala Glu Ala Leu

135 140 145gcc cgc acg agg gat gct tgg cgt ggc atg cgt act gag gtt att ggc 595Ala Arg Thr Arg Asp Ala Trp Arg Gly Met Arg Thr Glu Val Ile Gly150 155 160 165ggc cag ctg ctt gat att tat cta gag tcg cac gcc aac gag tcg gtg 643Gly Gln Leu Leu Asp Ile Tyr Leu Glu Ser His Ala Asn Glu Ser Val

170 175 180gag ctt gcg gat tct gtc aac cgc ttc aaa acg gcc gct tac acg att 691Glu Leu Ala Asp Ser Val Asn Arg Phe Lys Thr Ala Ala Tyr Thr Ile

185 190 195gcg cgc cca ttg cac ctg ggc gcc tcc att gct ggc ggt tcg ccg cag 739Ala Arg Pro Leu His Leu Gly Ala Ser Ile Ala Gly Gly Ser Pro Gln

200 205 210ctt atc gac gcg ctc ctc cac tac ggc cac gac atc ggc att gca ttc 787Leu Ile Asp Ala Leu Leu His Tyr Gly His Asp Ile Gly Ile Ala Phe

215 220 225cag ttg agg gat gat ctg ctt ggt gtg ttt ggg gat ccc gct atc acc 835Gln Leu Arg Asp Asp Leu Leu Gly Val Phe Gly Asp Pro Ala Ile Thr230 235 240 245ggc aaa cca gct gga gac gat atc cgt gaa ggc aag cgc act gtt ctt 883Gly Lys Pro Ala Gly Asp Asp Ile Arg Glu Gly Lys Arg Thr Val Leu

250 255 260ctt gcg ctc gct cta caa cgc gct gat aag caa tct cct gaa gct gca 931Leu Ala Leu Ala Leu Gln Arg Ala Asp Lys Gln Ser Pro Glu Ala Ala

265 270 275acg gcc att cgc gca ggt gtt gga aag gtg act tca cca gaa gat att 979Thr Ala Ile Arg Ala Gly Val Gly Lys Val Thr Ser Pro Glu Asp Ile

280 285 290gct gtc att aca gag cat att cga gct act ggt gct gaa gaa gaa gtt 1027Ala Val Ile Thr Glu His Ile Arg Ala Thr Gly Ala Glu Glu Glu Val

295 300 305gag cag cga att tcc cag ctg act gaa tcc ggt ttg gct cac ctc gat 1075Glu Gln Arg Ile Ser Gln Leu Thr Glu Ser Gly Leu Ala His Leu Asp310 3l5 320 325gat gta gac atc ccc gat gag gtg cgc gca cag ttg cgg gca ctg gct 1123Asp Val Asp Ile Pro Asp Glu Val Arg Ala Gln Leu Arg Ala Leu Ala

330 335 340atc cgc tca acc gaa cgt cgg atg tagtagacgc gtatgacact ttt 1170Ile Arg Ser Thr Glu Arg Arg Met

345<210>248<211>349<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>248Val Arg Asp Arg Leu Thr Gln Phe Leu Asp Ala Gln Glu Leu Thr Ile 151015 Ala Asp Ile Gly Ala Pro Val Thr Asp Ala Val Ala His Leu Arg Ser

20 25 30Phe Val Leu Asn Gly Gly Lys Arg Ile Arg Pro Leu Tyr Ala Trp Ala

35 4045Gly Phe Leu Ala Ala Gln Gly His Lys Asn Ser Ser Glu Lys Leu Glu

50 55 60Ser Val Leu Asp Ala Ala Ala Ser Leu Glu Phe Ile Gln Ala Cys Ala 65 70 75 80Leu Ile His Asp Asp Ile Ile Asp Ser Ser Asp Thr Arg Arg Gly Ala

85 90 95Pro Thr Val His Arg Ala Val Glu Ala Asp His Arg Ala Asn Asn Phe

100 105 110Glu Gly Asp Pro Glu His Phe Gly Val Ser Val Ser Ile Leu Ala Gly

115 120 125Asp Met Ala Leu Val Trp Ala Glu Asp Met Leu Gln Asp Ser Gly Leu

130 135 140Ser Ala Glu Ala Leu Ala Arg Thr Arg Asp Ala Trp Arg Gly Met Arg145 150 155 160Thr Glu Val Ile Gly Gly Gln Leu Leu Asp Ile Tyr Leu Glu Ser His

165 170 175Ala Asn Glu Ser Val Glu Leu Ala Asp Ser Val Asn Arg Phe Lys Thr

180 185 190Ala Ala Tyr Thr Ile Ala Arg Pro Leu His Leu Gly Ala Ser Ile Ala

195 200 205Gly Gly Ser Pro Gln Leu Ile Asp Ala Leu Leu His Tyr Gly His Asp

210 215 220Ile Gly Ile Ala Phe Gln Leu Arg Asp Asp Leu Leu Gly Val Phe Gly225 230 235 240Asp Pro Ala Ile Thr Gly Lys Pro Ala Gly Asp Asp Ile Arg Glu Gly

245 250 255Lys Arg Thr Val Leu Leu Ala Leu Ala Leu Gln Arg Ala Asp Lys Gln

260 265 270Ser Pro Glu Ala Ala Thr Ala Ile Arg Ala Gly Val Gly Lys Val Thr

275 280 285Ser Pro Glu Asp Ile Ala Val Ile Thr Glu His Ile Arg Ala Thr Gly

290 295 300Ala Glu Glu Glu Val Glu Gln Arg Ile Ser Gln Leu Thr Glu Ser Gly305 310 315 320Leu Ala His Leu Asp Asp Val Asp Ile Pro Asp Glu Val Arg Ala Gln

325 330 335Leu Arg Ala Leu Ala Ile Arg Ser Thr Glu Arg Arg Met

340345<210>249<211>852<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (829)<223>RXA01067<400>249ggctttaagg ccgaggtgcc tggctgaact gcagcccctc cagaccctga gatcaggcta 60aatggcaaac acaaatagtt tgcatggcag aatagcttag gtg agt gaa ttc caa 115

Val Ser Glu Phe Gln

1 5gta ccc gaa atc cct gcc caa ttc cta ccc aag cat att gcg ctt gtc 163Val Pro Glu Ile Pro Ala Gln Phe Leu Pro Lys His Ile Ala Leu Val

10 15 20atg gat gga aat gga cgc tgg gct acc gag cgt ggc atg aag cgc acc 211Met Asp Gly Asn Gly Arg Trp Ala Thr Glu Arg Gly Met Lys Arg Thr

25 30 35gaa ggc cat aag cgt ggc gag gca gtc ctg ctt gat gtt gtt gat gca 259Glu Gly His Lys Arg Gly Glu Ala Val Leu Leu Asp Val Val Asp Ala

40 45 50tgc att gaa ctt ggt gtt ccg tac ctt tct gct tat gcc ttc tct act 307Cys Ile Glu Leu Gly Val Pro Tyr Leu Ser Ala Tyr Ala Phe Ser Thr

55 60 65gaa aactgg cgt cgt tcc acc gat gag gtc cgt ttc ctc atg gga ttc 355Glu Asn Trp Arg Arg Ser Thr Asp Glu Val Arg Phe Leu Met Gly Phe 70 75 80 85aac cga gat gtg ctg cga cga caa cgc gat gac cta cat gaa aag ggc 403Asn Arg Asp Val Leu Arg Arg Gln Arg Asp Asp Leu His Glu Lys Gly

90 95 100gtt cgt gtg cgt tgg gtt ggc cgt cgt ccc cgc ctgtgg cgt tcg gtt 451Val Arg Val Arg Trp Val Gly Arg Arg Pro Arg Leu Trp Arg Ser Val

105 110 115atc cgt gag ctg gaa act gcg gaa gag cta acc aaa gac aac acc acc 499Ile Arg Glu Leu Glu Thr Ala Glu Glu Leu Thr Lys Asp Asn Thr Thr

120 125 130atg acc ttg gcc atg tgt gtg aac tat ggt gga cgc gcc gaa atc atc 547Met Thr Leu Ala Met Cys Val Asn Tyr Gly Gly Arg Ala Glu Ile Ile

135 140 145gac gca gcc cgc gac atc gcc cgc ctt gca gct gaa ggc aaa ctg cgc 595Asp Ala Ala Arg Asp Ile Ala Arg Leu Ala Ala Glu Gly Lys Leu Arg150 155 160 165ccg gaa caa atc act gag aag acc ttc ccg aac ttc ctc gac gaa cct 643Pro Glu Gln Ile Thr Glu Lys Thr Phe Pro Asn Phe Leu Asp Glu Pro

170 175 180gac atg cca gac gtc gac ctg ttc ctg cgc cca tcc ggt gag aag cgc 691Asp Met Pro Asp Val Asp Leu Phe Leu Arg Pro Ser Gly Glu Lys Arg

185 190 195acg tca aac ttc ctg ctg tgg cag tct gcc tac gcg gaa atg gtc tac 739Thr Ser Asn Phe Leu Leu Trp Gln Ser Ala Tyr Ala Glu Met Val Tyr

200 205 210caa gac aag ctg ttc cct gat ttc acg cag caa gat ctg tac gac gcg 787Gln Asp Lys Leu Phe Pro Asp Phe Thr GlnGln Asp Leu Tyr Asp Ala

215220225 gtc ctg gaa tac gcc aag cgg gat cgc aga ttc gga agc gca 829Val Leu Glu Tyr Ala Lys Arg Asp Arg Arg Phe Gly Ser Ala 230235240 taa tgcccac caaccagccg acg 852<210>250<211>243<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>250Val Ser Glu Phe Gln Val Pro Glu Ile Pro Ala Gln Phe Leu Pro Lys 151015 His Ile Ala Leu Val Met Asp Gly Asn Gly Arg Trp Ala Thr Glu Arg

20 25 30Gly Met Lys Arg Thr Glu Gly His Lys Arg Gly Glu Ala Val Leu Leu

35 40 45Asp Val Val Asp Ala Cys Ile Glu Leu Gly Val Pro Tyr Leu Ser Ala

50 55 60Tyr Ala Phe Ser Thr Glu Asn Trp Arg Arg Ser Thr Asp Glu Val Arg 65 70 75 80Phe Leu Met Gly Phe Asn Arg Asp Val Leu Arg Arg Gln Arg Asp Asp

85 90 95Leu His Glu Lys Gly Val Arg Val Arg Trp Val Gly Arg Arg Pro Arg

100 105 110Leu Trp Arg Ser Val Ile Arg Glu Leu Glu Thr Ala Glu Glu Leu Thr

115 120 125Lys Asp Asn Thr Thr Met Thr Leu Ala Met Cys Val Asn Tyr Gly Gly

130 135 140Arg Ala Glu Ile Ile Asp Ala Ala Arg Asp Ile Ala Arg Leu Ala Ala145 150 155 160Glu Gly Lys Leu Arg Pro Glu Gln Ile Thr Glu Lys Thr Phe Pro Asn

165 170 175Phe Leu Asp Glu Pro Asp Met Pro Asp Val Asp Leu Phe Leu Arg Pro

180 185 190Ser GlyGlu Lys Arg Thr Ser Asn Phe Leu Leu Trp Gln Ser Ala Tyr

195 200 205Ala Glu Met Val Tyr Gln Asp Lys Leu Phe Pro Asp Phe Thr Gln Gln

210215220 Asp Leu Tyr Asp Ala Val Leu Glu Tyr Ala Lys Arg Asp Arg Arg Phe 225230235240 Gly Ser Ala<210>251<211>564<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (541)<223>RXA01269<400>251gattatctct gcgccgattc agctggcaat agcagcagtt gtattgagag ctcatggtcg 60tccgattcta tttcgtcaac cacgacctgg gaaagacggt gtg gta ttt gag atg 115

Val Val Phe Glu Met

1 5att aag ttt cga acc atg ctt gaa cca gat gaa aaa cat gta act gat 163Ile Lys Phe Arg Thr Met Leu Glu Pro Asp Glu Lys His Val Thr Asp

10 15 20gaa cag cgt cta act aaa gtt gga aag ctt ctg cgg gaa acg agt tta 211Glu Gln Arg Leu Thr Lys Val Gly Lys Leu Leu Arg Glu Thr Ser Leu

25 30 35gat gag tta cct aca ctc tgg aat gta ttt aaa ggt gat atg agc ctt 259Asp Glu Leu Pro Thr Leu Trp Asn Val Phe Lys Gly Asp Met Ser Leu

40 45 50gta ggg cct cga cct ttg ctt gtt agc tat ctg gaa cat tac tct tct 307Val Gly Pro Arg Pro Leu Leu Val Ser Tyr Leu Glu His Tyr Ser Ser

55 60 65gaa caa gct cga cgc cat gaa gtt cgt cct ggg att act ggt ttg gct 355Glu Gln Ala Arg Arg His Glu Val Arg Pro Gly Ile Thr Gly Leu Ala 70 75 80 85cag gtg aat ggc cgt aat caa act act tgg gat gaa cga ctt aag ttg 403Gln Val Asn Gly Arg AsnGln Thr Thr Trp Asp Glu Arg Leu Lys Leu

90 95 100gat gtc gaa tat gtg gat cgc tgt agt ttg aaa cta gat ttc aaa ata 451Asp Val Glu Tyr Val Asp Arg Cys Ser Leu Lys Leu Asp Phe Lys Ile

105 110 115tta atc gcc act gta aaa aca gtt ctt tct aaa aag ggc att agt aat 499Leu Ile Ala Thr Val Lys Thr Val Leu Ser Lys Lys Gly Ile Ser Asn

120 125 130gaa ggt cat gtc acg atg cca tcc ttc att gaa gaa aga aaa 541Glu Gly His Val Thr Met Pro Ser Phe Ile Glu Glu Arg Lys

135140145 tagcaggtaa aaattttact ttc 564<210>252<211>147<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>252Val Val Phe Glu Met Ile Lys Phe Arg Thr Met Leu Glu Pro Asp Glu 151015 Lys His Val Thr Asp Glu Gln Arg Leu Thr Lys Val Gly Lys Leu Leu

20 25 30Arg Glu Thr Ser Leu Asp Glu Leu Pro Thr Leu Trp Asn Val Phe Lys

35 40 45Gly Asp Met Ser Leu Val Gly Pro Arg Pro Leu Leu Val Ser Tyr Leu

50 55 60Glu His Tyr Ser Ser Glu Gln Ala Arg Arg His Glu Val Arg Pro Gly 65 70 75 80Ile Thr Gly Leu Ala Gln Val Asn Gly Arg Asn Gln Thr Thr Trp Asp

85 90 95Glu Arg Leu Lys Leu Asp Val Glu Tyr Val Asp Arg Cys Ser Leu Lys

100 105 110Leu Asp Phe Lys Ile Leu Ile Ala Thr Val Lys Thr Val Leu Ser Lys

115 120 125Lys Gly Ile Ser Asn Glu Gly His Val Thr Met Pro Ser Phe Ile Glu

130135140 Glu Arg Lys145<210>253<211>554<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) · (531)<223>RXA01205<400>253gta tcg gcc tat ccg ccg gcc atc atc gca gcg gct ctc gta gga att 48Val Ser Ala Tyr Pro Pro Ala Ile Ile Ala Ala Ala Leu Val Gly Ile 151015 tgc gcg gga gtt ttg ccc cat aat ttt gaa ccc tcg cga ata ttt atg 96Cys Ala Gly Val Leu Pro His Asn Phe Glu Pro Ser Arg Ile Phe Met<400>-253 gta tcg gcc tat ccg ccg gcc atc atc gca gcg gct ctc gta gga att Val Ser Ala Tyr Pro Pro Ala Ile Ile Ala Ala Ala Leu Val Gly Ile tgc gcg gga gtt ttg ccc cat aat ttt gaa ccc tcg cga ata ttt atg

20 25 30ggc gat tcc ggc tcc atg ctc atc ggc ctg ctg ttg gct gca gca tcg 144Gly Asp Ser Gly Ser Met Leu Ile Gly Leu Leu Leu Ala Ala Ala Ser

35 40 45acc tca gcg tca gga aaa atc aac atg agc ctg tat ggc gca gct gat 192Thr Ser Ala Ser Gly Lys Ile Asn Met Ser Leu Tyr Gly Ala Ala Asp

50 55 60ttt atc gca ttg atc tca ccc atc atc gtt gtt ctc gcc gcc gtg gcc 240Phe Ile Ala Leu Ile Ser Pro Ile Ile Val Val Leu Ala Ala Val Ala 65 70 75 80atc cca ctg ctc gac ctc gtg atg gca gtg gtt agg cgc gtg ggc agg 288Ile Pro Leu Leu Asp Leu Val Met Ala Val Val Arg Arg Val Gly Arg

85 90 95gga gca tca ccc ttt tcc ccg gac aaa atg cat ctg cac cac cga ctg 336Gly Ala Ser Pro Phe Ser Pro Asp Lys Met His Leu His His Arg Leu

100 105 110ctg tcc atc gga cac acc cat agg cgc gtg gtc cta gtg ctc tac acc 384Leu Ser Ile Gly His Thr His Arg Arg Val Val Leu Val Leu Tyr Thr

115 120 125tgg gcg agc gcc gtg gca ttc ggc gca gtg agc ttc tcc gtc gtt ccg 432Trp Ala Ser Ala Val Ala Phe Gly Ala Val Ser Phe Ser Val Val Pro

130 135 140cca ctg ttt gcc acc gga tcg agc atc tgt ggc atc ctc atc gcc gtc 480Pro Leu Phe Ala Thr Gly Ser Ser Ile Cys Gly Ile Leu Ile Ala Val145 150 155 160gct gtc aca gcc gtg cca gtg atg aaa agc cgg cga gcc gcc aaa ctt 528Ala Val Thr Ala Val Pro Val Met Lys Ser Arg Arg Ala Ala Lys Leu

165170175 gat taagtgattg tcactttgga ttg 554Asp<210>254<211>177<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>254Val Ser Ala Tyr Pro Pro Ala Ile Ile Ala Ala Ala Leu Val Gly Ile 151015 Cys Ala Gly Val Leu Pro His Asn Phe Glu Pro Ser Arg Ile Phe Met

20 25 30Gly Asp Ser Gly Ser Met Leu Ile Gly Leu Leu Leu Ala Ala Ala Ser

35 40 45Thr Ser Ala Ser Gly Lys Ile Asn Met Ser Leu Tyr Gly Ala Ala Asp

50 55 60Phe Ile Ala Leu Ile Ser Pro Ile Ile Val Val Leu Ala Ala Val Ala 65 70 75 80Ile Pro Leu Leu Asp Leu Val Met Ala Val Val Arg Arg Val Gly Arg

85 90 95Gly Ala Ser Pro Phe Ser Pro Asp Lys Met His Leu His His Arg Leu

100 105 110Leu Ser Ile Gly His Thr His Arg Arg Val Val Leu Val Leu Tyr Thr

115 120 125Trp Ala Ser Ala Val Ala Phe Gly Ala Val Ser Phe Ser Val Val Pro

130135 140Pro Leu Phe Ala Thr Gly Ser Ser Ile Cys Gly Ile Leu Ile Ala Val145 150 155 160Ala Val Thr Ala Val Pro Val Met Lys Ser Arg Arg Ala Ala Lys Leu

165170175 Asp<210>255<211>882<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (859)<223>RXA01576<400>255atcggtgatc tttcgcgatt gatacgtgcg cgattgcgtg cccgccagct gctcaagatc 60aatggatttc atgacaatca agttatcatc actggggtcg gtg gca cct aac agg 115

Val Ala Pro Asn Arg

1 5aaa atc agc cat cat gca cta ggc tct att cct atc atg gat gca tca 163Lys Ile Ser His His Ala Leu Gly Ser Ile Pro Ile Met Asp Ala Ser

10 15 20aaa aac agc gac ttt aaa gac acc tgg cta gtc gta cct tgt tat aac 211Lys Asn Ser Asp Phe Lys Asp Thr Trp Leu Val Val Pro Cys Tyr Asn

25 30 35gag gca aca gtt atc cgg gaa gtt tta gag aac gca ctc aaa aca ttc 259Glu Ala Thr Val Ile Arg Glu Val Leu Glu Asn Ala Leu Lys Thr Phe

40 45 50cct aat att gtt gcg gtc aac gat ggc tcc ccg gac aac tcc gcg gaa 307Pro Asn Ile Val Ala Val Asn Asp Gly Ser Pro Asp Asn Ser Ala Glu

55 60 65gaa atc cat gcg gcc ggc gca cac ctg gtc aac cac ccc gtg aac ctc 355Glu Ile His Ala Ala Gly Ala His Leu Val Asn His Pro Val Asn Leu 70 75 80 85gga caa ggt gcc gcg atc caa acc ggc atc gaa tac gcc cgc aag caa 403Gly Gln Gly Ala Ala Ile Gln Thr Gly Ile Glu Tyr Ala Arg Lys Gln

90 95 100ccc ggt gca aaa tac ttt gta act ttc gac gcc gac ggc caa cac caa 451Pro Gly Ala Lys Tyr Phe Val Thr Phe Asp Ala Asp Gly Gln His Gln

105 110 115gtg aaa gac gtt atc cgc atg gtg gag cga ctg cgt gcc gag gac gtg 499Val Lys Asp Val Ile Arg Met Val Glu Arg Leu Arg Ala Glu Asp Val

120 125 130gac att atc gtc ggc acg cgt ttt gga cgc cca cgc caa gcc gat gac 547Asp Ile Ile Val Gly Thr Arg Phe Gly Arg Pro Arg Gln Ala Asp Asp

135 140 145cag gtg cca cta atc aag cgc ctt gtg ctg cgc acc gtg gtc ctg ctg 595Gln Val Pro Leu Ile Lys Arg Leu Val Leu Arg Thr Val Val Leu Leu150 155 160 165tca ccg aaa acc cgc cga ctt ggg ctc acc gac gcc cac aac ggc ctg 643Ser Pro Lys Thr Arg Arg Leu Gly Leu Thr Asp Ala His Asn Gly Leu

170 175 180cgc gta ttc aac caa aaa gtg gcg cag gaa atg aac atc cgc atg aac 691Arg Val Phe Asn Gln Lys Val Ala Gln Glu Met Asn Ile Arg Met Asn

185 190 195ggc atg tcg cat gca tcc gaa atc gtc gac caa atc gat gaa cgc ggc 739Gly Met Ser His Ala Ser Glu Ile Val Asp Gln Ile Asp Glu Arg Gly

200 205 210tgg cgc att tca gaa gaa ccc gta gac atc ctc tac acc gaa tac tcc 787Trp Arg Ile Ser Glu Glu Pro Val Asp Ile Leu Tyr Thr Glu Tyr Ser

215 220 225atg agc aag ggg caa tcc ctg ctc aac ggc gta aac atc ctg gcc gac 835Met Ser Lys Gly Gln Ser Leu Leu Asn Gly Val Asn Ile Leu Ala Asp230 235 240 245ggc ttc cta gcg agg aga ctc cca tgacgcagac caccacccaa atc882Gly Phe Leu Ala Arg Arg Leu Pro

250<210>256<211>253<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>256Val Ala Pro Asn Arg Lys Ile Ser His His Ala Leu Gly Ser Ile Pro 151015 Ile Met Asp Ala Ser Lys Asn Ser Asp Phe Lys Asp Thr Trp Leu Val

20 25 30Val Pro Cys Tyr Asn Glu Ala Thr Val Ile Arg Glu Val Leu Glu Asn

35 40 45Ala Leu Lys Thr Phe Pro Asn Ile Val Ala Val Asn Asp Gly Ser Pro

50 55 60Asp Asn Ser Ala Glu Glu Ile His Ala Ala Gly Ala His Leu Val Asn 65 70 75 80His Pro Val Asn Leu Gly Gln Gly Ala Ala Ile Gln Thr Gly Ile Glu

85 90 95Tyr Ala Arg Lys Gln Pro Gly Ala Lys Tyr Phe Val Thr Phe Asp Ala

100 105 110Asp Gly Gln His Gln Val Lys Asp Val Ile Arg Met Val Glu Arg Leu

115 120 125Arg Ala Glu Asp Val Asp Ile Ile Val Gly Thr Arg Phe Gly Arg Pro

130 135 140Arg Gln Ala Asp Asp Gln Val Pro Leu Ile Lys Arg Leu Val Leu Arg145 150 155 160Thr Val Val Leu Leu Ser Pro Lys Thr Arg Arg Leu Gly Leu Thr Asp

165 170 175Ala His Asn Gly Leu Arg Val Phe Asn Gln Lys Val Ala Gln Glu Met

180 185 190Asn Ile Arg Met Asn Gly Met Ser His Ala Ser Glu Ile Val Asp Gln

195 200 205Ile Asp Glu Arg Gly Trp Arg Ile Ser Glu Glu Pro Val Asp Ile Leu

210 215 220Tyr Thr Glu Tyr Ser Met Ser Lys Gly Gln Ser Leu Leu Asn Gly Val225 230 235 240Asn Ile Leu Ala Asp Gly Phe Leu Ala Arg Arg Leu Pro

245250<210>257<211>1173<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1150)<223>RXN02309<400>257gtgccttccg tcgactacgg ttaaacaaaa agctttttgt ccatttcact ggattcaccg 60aaagaatgaa tccacactcg atcaccaaag gtagcgatga atg agt agc ggc cga 115

Met Ser Ser Gly Arg

1 5acc gtt cca acc cgt tcc cac ggg ctc gga aaa gaa ggt gta tcc acc 163Thr Val Pro Thr Arg Ser His Gly Leu Gly Lys Glu Gly Val Ser Thr

10 15 20aca gga gca tct cag gtc gag ttt ggt gat ccc gag cta acg gcc agg 211Thr Gly Ala Ser Gln Val Glu Phe Gly Asp Pro Glu Leu Thr Ala Arg

25 30 35atc aat gac gcc atg gtg cag gta gaa gaa ctc ctg cac act gaa cta 259Ile Asn Asp Ala Met Val Gln Val Glu Glu Leu Leu His Thr Glu Leu

40 45 50tcg tcc ggg gaa gac ttc ctc gtc gat atc gtc atg cac cta aca cga 307Ser Ser Gly Glu Asp Phe Leu Val Asp Ile Val Met His Leu Thr Arg

55 60 65gcc ggc ggc aaa cga ttc cgc ccc atg ttt gca ctg ctg gcc tcc gag 355Ala Gly Gly Lys Arg Phe Arg Pro Met Phe Ala Leu Leu Ala Ser Glu70 75 80 85ttc ggt gaa aaa cca ctc tcc gaa aac gtc atc aaa gcc gcc gtt gtc 403Phe Gly Glu Lys Pro Leu Ser Glu Asn Val Ile Lys Ala Ala Val Val

90 95 100gta gag atc acc cac ctg gcc acc ctg tac cac gac gat gtc atg gac 451Val Glu Ile Thr His Leu Ala Thr Leu Tyr His Asp Asp Val Met Asp

105 110 115gag gca tcc atg cgc cgc ggc gtc cca agt gct aac gcg cga tgg gac 499Glu Ala Ser Met Arg Arg Gly Val Pro Ser Ala Asn Ala Arg Trp Asp

120 125 130aac tcc gta gcc atc ctc gca ggc gac atc ctc cta gca cat gca tca 547Asn Ser Val Ala Ile Leu Ala Gly Asp Ile Leu Leu Ala His Ala Ser

135 140 145ggt ctg atg agt cag ctg ggt acc gac aca gtc gcc cac ttt gcc gaa 595Gly Leu Met Ser Gln Leu Gly Thr Asp Thr Val Ala His Phe Ala Glu150 155 160 165aca ttc ggc gaa cta gtc acc ggc caa atg cgc gaa aca gtc ggg cca 643Thr Phe Gly Glu Leu Val Thr Gly Gln Met Arg Glu Thr Val Gly Pro

170 175 180cgc gac acc gac ccg atc gag cac tac acc aac gta atc cgt gaa aaa 691Arg Asp Thr Asp Pro Ile Glu His Tyr Thr Asn Val Ile Arg Glu Lys

185 190 195act ggt gtc ctc atc gcc tcc gca ggc tat ttg gga gcc atg cac gca 739Thr Gly Val Leu Ile Ala Ser Ala Gly Tyr Leu Gly Ala Met His Ala

200 205 210ggc gcc gca cct gaa cac atc gac gcc ctg aag aac ttc ggc gca gcc 787Gly Ala Ala Pro Glu His Ile Asp Ala Leu Lys Asn Phe Gly Ala Ala

215 220 225gtc ggc atg atc ttc caa atc gtc gac gac atc atc gac atc ttc tcg 835Val Gly Met Ile Phe Gln Ile Val Asp Asp Ile Ile Asp Ile Phe Ser230 235 240 245gaa acc cac gaa tccgga aaa acg ccc ggc acc gac ctc cgc gaa ggt 883Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr Asp Leu Arg Glu Gly

250 255 260gta ttc acc ctc cca gtg ctc tac gca ctc cgt gaa gac acc ccc gtc 931Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg Glu Asp Thr Pro Val

265 270 275ggc gca gaa ctc cgc gac atc ctc acc ggc cct cta gaa gac gac gag 979Gly Ala Glu Leu Arg Asp Ile Leu Thr Gly Pro Leu Glu Asp Asp Glu

280 285 290acc gtc aac cac gtc ctc gag ctc ctc tcc caa tcc ggc gga cgc caa 1027Thr Val Asn His Val Leu Glu Leu Leu Ser Gln Ser Gly Gly Arg Gln

295 300 305gca gcc ctc gac gag gtc tac cgc tac atg gac atc gcc aac gca gaa 1075Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp Ile Ala Asn Ala Glu310 315 320 325ctc gac cgc ctc cca gac agc acc gtc aag gaa gcc ctc cgc aac ctt 1123Leu Asp Arg Leu Pro Asp Ser Thr Val Lys Glu Ala Leu Arg Asn Leu

330 335 340gca acc ttc aca gtc aag cgc gtc gga taaccccgta atccaccact 1170Ala Thr Phe Thr Val Lys Arg Val Gly

345350 taa1173<210>258<211>350<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>258Met Ser Ser Gly Arg Thr Val Pro Thr Arg Ser His Gly Leu Gly Lys 151015 Glu Gly Val Ser Thr Thr Gly Ala Ser Gln Val Glu Phe Gly Asp Pro

20 25 30Glu Leu Thr Ala Arg Ile Asn Asp Ala Met Val Gln Val Glu Glu Leu

35 40 45Leu His Thr Glu Leu Ser Ser Gly Glu Asp Phe Leu Val Asp Ile Val

50 55 60Met His Leu Thr Arg Ala Gly Gly Lys Arg Phe Arg Pro Met Phe Ala 65 70 75 80Leu Leu Ala Ser Glu Phe Gly Glu Lys Pro Leu Ser Glu Asn Val Ile

85 90 95Lys Ala Ala Val Val Val Glu Ile Thr His Leu Ala Thr Leu Tyr His

100 105 110Asp Asp Val Met Asp Glu Ala Ser Met Arg Arg Gly Val Pro Ser Ala

115 120 125Asn Ala Arg Trp Asp Asn Ser Val Ala Ile Leu Ala Gly Asp Ile Leu

130 135 140Leu Ala His Ala Ser Gly Leu Met Ser Gln Leu Gly Thr Asp Thr Val145 150 155 160Ala His Phe Ala Glu Thr Phe Gly Glu Leu Val Thr Gly Gln Met Arg

165 170 175Glu Thr Val Gly Pro Arg Asp Thr Asp Pro Ile Glu His Tyr Thr Asn

180 185 190Val Ile Arg Glu Lys Thr Gly Val Leu Ile Ala Ser Ala Gly Tyr Leu

195 200 205Gly Ala Met His Ala Gly Ala Ala Pro Glu His Ile Asp Ala Leu Lys

210 215 220Asn Phe Gly Ala Ala Val Gly Met Ile Phe Gln Ile Val Asp Asp Ile225 230 235 240Ile Asp Ile Phe Ser Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr

245 250 255Asp Leu Arg Glu Gly Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg

260 265 270Glu Asp Thr Pro Val Gly Ala Glu Leu Arg Asp Ile Leu Thr Gly Pro

275280 285Leu Glu Asp Asp Glu Thr Val Asn His Val Leu Glu Leu Leu Ser Gln

290 295 300Ser Gly Gly Arg Gln Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp305 310 315 320Ile Ala Asn Ala Glu Leu Asp Arg Leu Pro Asp Ser Thr Val Lys Glu

325 330 335Ala Leu Arg Asn Leu Ala Thr Phe Thr Val Lys Arg Val Gly

340345350<210>259<211>1075<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1075)<223>FRXA02309<400>259gtgccttccg tcgactacgg ttaaacaaaa agctttttgt ccatttcact ggattcaccg 60aaagaatgaa tccacactcg atcaccaaag gtagcgatga atg agt agc ggc cga 115

Met Ser Ser Gly Arg

1 5acc gtt cca acc cgt tcc cac ggg ctc gga aaa gaa ggt gta tcc acc 163Thr Val Pro Thr Arg Ser His Gly Leu Gly Lys Glu Gly Val Ser Thr

10 15 20aca gga gca tct cag gtc gag ttt ggt gat ccc gag cta acg gcc agg 211Thr Gly Ala Ser Gln Val Glu Phe Gly Asp Pro Glu Leu Thr Ala Arg

25 30 35atc aat gac gcc atg gtg cag gta gaa gaa ctc ctg cac act gaa cta 259Ile Ash Asp Ala Met Val Gln Val Glu Glu Leu Leu His Thr Glu Leu

40 45 50tcg tcc ggg gaa gac ttc ctc gtc gat atc gtc atg cac cta aca cga 307Ser Ser Gly Glu Asp Phe Leu Val Asp Ile Val Met His Leu Thr Arg

55 60 65gcc ggc ggc aaa cga ttc cgc ccc atg ttt gca ctg ctg gcc tcc gag355Ala Gly Gly Lys Arg Phe Arg Pro Met Phe Ala Leu Leu Ala Ser Glu 70 75 80 85ttc ggt gaa aaa cca ctc tcc gaa aac gtc atc aaa gcc gcc gtt gtc 403Phe Gly Glu Lys Pro Leu Ser Glu Asn Val Ile Lys Ala Ala Val Val

90 95 100gta gag atc acc cac ctg gcc acc ctg tac cac gac gat gtc atg gac 451Val Glu Ile Thr His Leu Ala Thr Leu Tyr His Asp Asp Val Met Asp

105 110 115gag gca tcc atg cgc cgc ggc gtc cca agt gct aac gcg cga tgg gac 499Glu Ala Ser Met Arg Arg Gly Val Pro Ser Ala Asn Ala Arg Trp Asp

120 125 130aac tcc gta gcc atc ctc gca ggc gac atc ctc cta gca cat gca tca 547Asn Ser Val Ala Ile Leu Ala Gly Asp Ile Leu Leu Ala His Ala Ser

135 140 145ggt ctg atg agt cag ctg ggt acc gac aca gtc gcc cac ttt gcc gaa 595Gly Leu Met Ser Gln Leu Gly Thr Asp Thr Val Ala His Phe Ala Glu150 155 160 165aca ttc ggc gaa cta gtc acc ggc caa atg cgc gaa aca gtc ggg cca 643Thr Phe Gly Glu Leu Val Thr Gly Gln Met Arg Glu Thr Val Gly Pro

170 175 180cgc gac acc gac ccg atc gag cac tac acc aac gta atc cgt gaa aaa 691Arg Asp Thr Asp Pro Ile Glu His Tyr Thr Asn Val Ile Arg Glu Lys

185 190 195act ggt gtc ctc atc gcc tcc gca ggc tat ttg gga gcc atg cac gca 739Thr Gly Val Leu Ile Ala Ser Ala Gly Tyr Leu Gly Ala Met His Ala

200 205 210ggc gcc gca cct gaa cac atc gac gcc ctg aag aac ttc ggc gca gcc 787Gly Ala Ala Pro Glu His Ile Asp Ala Leu Lys Asn Phe Gly Ala Ala

215220 225gtc ggc atg atc ttc caa atc gtc gac gac atc atc gac atc ttc tcg 835Val Gly Met Ile Phe Gln Ile Val Asp Asp Ile Ile Asp Ile Phe Ser230 235 240 245gaa acc cac gaa tcc gga aaa acg ccc ggc acc gac ctc cgc gaa ggt 883Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr Asp Leu Arg Glu Gly

250 255 260gta ttc acc ctc cca gtg ctc tac gca ctc cgt gaa gac acc ccc gtc 931Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg Glu Asp Thr Pro Val

265 270 275ggc gca gaa ctc cgc gac atc ctc acc ggc cct cta gaa gac gac gag 979Gly Ala Glu Leu Arg Asp Ile Leu Thr Gly Pro Leu Glu Asp Asp Glu

280 285 290acc gtc aac cac gtc ctc gag ctc ctc tcc caa tcc ggc gga cgc caa 1027Thr Val Asn His Val Leu Glu Leu Leu Ser Gln Ser Gly Gly Arg Gln

295300305 gca gcc ctc gac gag gtc tac cgc tac atg gac atc gcc aac gca gaa 1075Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp Ile Ala Asn Ala Glu 310315320325<210>260<211>325<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>260Met Ser Ser Gly Arg Thr Val Pro Thr Arg Ser His Gly Leu Gly Lys 151015 Glu Gly Val Ser Thr Thr Gly Ala Ser Gln Val Glu Phe Gly Asp Pro

20 25 30Glu Leu Thr Ala Arg Ile Asn Asp Ala Met Val Gln Val Glu Glu Leu

35 40 45Leu His Thr Glu Leu Ser Ser Gly Glu Asp Phe Leu Val Asp Ile Val

50 55 60Met His Leu Thr Arg Ala Gly Gly Lys Arg Phe Arg Pro Met Phe Ala 65 70 75 80Leu Leu Ala Ser Glu Phe Gly Glu Lys Pro Leu Ser Glu Asn Val Ile

85 90 95Lys Ala Ala Val Val Val Glu Ile Thr His Leu Ala Thr Leu Tyr His

100 105 110Asp Asp Val Met Asp Glu Ala Ser Met Arg Arg Gly Val Pro Ser Ala

115 120 125Asn Ala Arg Trp Asp Asn Ser Val Ala Ile Leu Ala Gly Asp Ile Leu

130 135 140Leu Ala His Ala Ser Gly Leu Met Ser Gln Leu Gly Thr Asp Thr Val145 150 155 160Ala His Phe Ala Glu Thr Phe Gly Glu Leu Val Thr Gly Gln Met Arg

165 170 175Glu Thr Val Gly Pro Arg Asp Thr Asp Pro Ile Glu His Tyr Thr Asn

180 185 190Val Ile Arg Glu Lys Thr Gly Val Leu Ile Ala Ser Ala Gly Tyr Leu

195 200 205Gly Ala Met His Ala Gly Ala Ala Pro Glu His Ile Asp Ala Leu Lys

210 215 220Asn Phe Gly Ala Ala Val Gly Met Ile Phe Gln Ile Val Asp Asp Ile225 230 235 240Ile Asp Ile Phe Ser Glu Thr His Glu Ser Gly Lys Thr Pro Gly Thr

245 250 255Asp Leu Arg Glu Gly Val Phe Thr Leu Pro Val Leu Tyr Ala Leu Arg

260 265 270Glu Asp Thr Pro Val Gly Ala Glu Leu Arg Asp Ile Leu Thr Gly Pro

275 280 285Leu Glu Asp Asp Glu Thr Val Asn His Val Leu Glu Leu Leu Ser Gln

290 295 300Ser Gly Gly Arg Gln Ala Ala Leu Asp Glu Val Tyr Arg Tyr Met Asp305310 315 320Ile Ala Asn Ala Glu

325<210>261<211>1767<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1744)<223>RXN00477<400>261tgcgggagcg aatcagagtt ccacttcata tcaaactctc tacactcgct agagccacga 60tgaaaggtct atctatgagc atctacagaa agaattcgtg atg aag gtc tcg act 115

Met Lys Val Ser Thr

1 5aaa act cca cgc tcc tca ggt acc gcc gta gtc ata ggc gca ggt gtt 163Lys Thr Pro Arg Ser Ser Gly Thr Ala Val Val Ile Gly Ala Gly Val

10 15 20 gct ggt tta gcc act tct gca ctt tta gca cgt gat ggc tgg caa gta 211Ala Gly Leu Ala Thr Ser Ala Leu Leu Ala Arg Asp Gly Trp Gln Val

25 30 35act gtt ttg gaa aaa aat act gat gtc ggt ggc cga gct gga tcg ctt 259Thr Val Leu Glu Lys Asn Thr Asp Val Gly Gly Arg Ala Gly Ser Leu

40 45 50gaa ata tca ggc ttt cct ggc ttt cga tgg gat acc gga cct tct tgg 307Glu Ile Ser Gly Phe Pro Gly Phe Arg Trp Asp Thr Gly Pro Ser Trp

55 60 65tac ctc atg ccc gag gcc ttt gac cat ttc ttc gca ctt ttt ggt gca 355Tyr Leu Met Pro Glu Ala Phe Asp His Phe Phe Ala Leu Phe Gly Ala 70 75 80 85tgt act tct gat tat ctc gat ttg gta gaa tta acg cct ggt tat cga 403Cys Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu Thr Pro Gly Tyr Arg

90 95 100gtt ttt tct ggc aca cat gac gct gtc gat gtc ccc act ggg cgt gaa 451Val Phe Ser Gly ThrHis Asp Ala Val Asp Val Pro Thr Gly Arg Glu

105 110 115gaa gca att gcg cta ttc gaa tcc atc gaa ccc ggc gcg ggt gca aaa 499Glu Ala Ile Ala Leu Phe Glu Ser Ile Glu Pro Gly Ala Gly Ala Lys

120 125 130cta gga aat tat ctt gat agc gcg gca gac gcc tat gac att gcc att 547Leu Gly Asn Tyr Leu Asp Ser Ala Ala Asp Ala Tyr Asp Ile Ala Ile

135 140 145gat aga ttc ctt tat aat aat ttc tcc acg tta ggc ccg ctg ctt cac 595Asp Arg Phe Leu Tyr Asn Asn Phe Ser Thr Leu Gly Pro Leu Leu His150 155 160 165cgg gat gta ctg acc cga gct ggc cga ctg ttt tct cta ctg acc cgt 643Arg Asp Val Leu Thr Arg Ala Gly Arg Leu Phe Ser Leu Leu Thr Arg

170 175 180tct tta caa aag tac gta aat agt caa ttc agt agc ccg gtg ttg cgc 691Ser Leu Gln Lys Tyr Val Asn Ser Gln Phe Ser Ser Pro Val Leu Arg

185 190 195cag atc cta acc tat cca gca gtc ttc ctg tct tcc cga ccc act act 739Gln Ile Leu Thr Tyr Pro Ala Val Phe Leu Ser Ser Arg Pro Thr Thr

200 205 210acc cca tcg atg tac cac ttg atg agt cat acc gat ttg gtg cag gga 787Thr Pro Ser Met Tyr His Leu Met Ser His Thr Asp Leu Val Gln Gly

215 220 225gtg aaa tac cct ata ggt ggt ttt act gca gtg gtt aac gct ctg cat 835Val Lys Tyr Pro Ile Gly Gly Phe Thr Ala Val Val Asn Ala Leu His230 235 240 245cag tta gcg ctg gaa aac ggg gtt gag ttt caa ctc gat tct gag gtc 883Gln Leu Ala Leu Glu Asn Gly Val Glu Phe Gln Leu Asp Ser Glu Val

250 255260att tcc atc aac act gct tca tcg agg ggc aac aca agc gcc aca ggt 931Ile Ser Ile Asn Thr Ala Ser Ser Arg Gly Asn Thr Ser Ala Thr Gly

265 270 275gtg agc ttg ctt cac aac aga aaa gtg caa aat cta gat gcg gat ctt 979Val Ser Leu Leu His Asn Arg Lys Val Gln Asn Leu Asp Ala Asp Leu

280 285 290gtg gtt tca gca ggc gac cta cac cat aca gaa aat aat ctg ctt ccc 1027Val Val Ser Ala Gly Asp Leu His His Thr Glu Asn Asn Leu Leu Pro

295 300 305cgg gaa ctt cga acc tat ccc gaa cga tat tgg tcc aat cgc aat cct 1075Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp Ser Asn Arg Asn Pro310 315 320 325gga att gga gcg gta tta atc ctc ctg ggc gta aaa gga gag tta ccc 1123Gly Ile Gly Ala Val Leu Ile Leu Leu Gly Val Lys Gly Glu Leu Pro

330 335 340cag ctc gac cat cac aac ctt ttc ttc agt gaa gat tgg aca gat gat 1171Gln Leu Asp His His Asn Leu Phe Phe Ser Glu Asp Trp Thr Asp Asp

345 350 355ttt gct gta gtt ttc gac ggg cct caa ctt acc cgc ccc cac aat gca 1219Phe Ala Val Val Phe Asp Gly Pro Gln Leu Thr Arg Pro His Asn Ala

360 365 370tca aat tcc att tat gtc tcc aag cct tca acg tcc gaa gac ggc gtt 1267Ser Asn Ser Ile Tyr Val Ser Lys Pro Ser Thr Ser Glu Asp Gly Val

375 380 385gca cct gct gga tac gaa aac ctt ttt gtt tta att ccg acc aag gcc 1315Ala Pro Ala Gly Tyr Glu Asn Leu Phe Val Leu Ile Pro Thr Lys Ala390 395 400 405tct agc agc atc ggc cac ggt gat gcg tat atg cag tcg gct tca gca 1363Ser Ser Ser Ile Gly His Gly Asp Ala Tyr Met Gln Ser Ala Ser Ala

410 415 420tcc gtg gaa aca atc gcg tca cat gca atc aat caa att gct acg caa 1411Ser Val Glu Thr Ile Ala Ser His Ala Ile Asn Gln Ile Ala Thr Gln

425 430 435gcc ggc atc cct gac ctc act gac cga att gtg gtc aaa cgc acc att 1459Ala Gly Ile Pro Asp Leu Thr Asp Arg Ile Val Val Lys Arg Thr Ile

440 445 450ggc cct gcg gat ttt gag cac cgc tac cat tca tgg gta ggc agt gcg 1507Gly Pro Ala Asp Phe Glu His Arg Tyr His Ser Trp Val Gly Ser Ala

455 460 465ctg ggt cca gca cat acc ctc aga cag tcc gct ttc tta aga ggg cgc 1555Leu Gly Pro Ala His Thr Leu Arg Gln Ser Ala Phe Leu Arg Gly Arg470 475 480 485aat agc tcc cgc aag gtc aat aac ctc ttc tat tcc ggt gcc acc acc 1603Asn Ser Ser Arg Lys Val Asn Asn Leu Phe Tyr Ser Gly Ala Thr Thr

490 495 500gtc ccg ggt gta gga ata ccc atg tgt tta att tct gcc gag aat att 1651Val Pro Gly Val Gly Ile Pro Met Cys Leu Ile Ser Ala Glu Asn Ile

505 510 515att aag cgt tta cat gcc gat acc agt gca gga cca ctg ccc gaa cca 1699Ile Lys Arg Leu His Ala Asp Thr Ser Ala Gly Pro Leu Pro Glu Pro

520 525 530ttg ccg cct aaa acg aca cca tct caa aag acc tca tac gat cat 1744Leu Pro Pro Lys Thr Thr Pro Ser Gln Lys Thr Ser Tyr Asp His

535540545 taaattttga tccctatcat cga 1767<210>262<211>548<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>262Met Lys Val Ser Thr Lys Thr Pro Arg Ser Ser Gly Thr Ala Val Val 151015 Ile Gly Ala Gly Val AlaGly Leu Ala Thr Ser Ala Leu Leu Ala Arg

20 25 30Asp Gly Trp Gln Val Thr Val Leu Glu Lys Asn Thr Asp Val Gly Gly

35 40 45Arg Ala Gly Ser Leu Glu Ile Ser Gly Phe Pro Gly Phe Arg Trp Asp

50 55 60Thr Gly Pro Ser Trp Tyr Leu Met Pro Glu Ala Phe Asp His Phe Phe 65 70 75 80Ala Leu Phe Gly Ala Cys Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu

85 90 95Thr Pro Gly Tyr Arg Val Phe Ser Gly Thr His Asp Ala Val Asp Val

100 105 110Pro Thr Gly Arg Glu Glu Ala Ile Ala Leu Phe Glu Ser Ile Glu Pro

115 120 125Gly Ala Gly Ala Lys Leu Gly Asn Tyr Leu Asp Ser Ala Ala Asp Ala

130 135 140Tyr Asp Ile Ala Ile Asp Arg Phe Leu Tyr Asn Asn Phe Ser Thr Leu145 150 155 160Gly Pro Leu Leu His Arg Asp Val Leu Thr Arg Ala Gly Arg Leu Phe

165 170 175Ser Leu Leu Thr Arg Ser Leu Gln Lys Tyr Val Asn Ser Gln Phe Ser

180 185 190Ser Pro Val Leu Arg Gln Ile Leu Thr Tyr Pro Ala Val Phe Leu Ser

195 200 205Ser Arg Pro Thr Thr Thr Pro Ser Met Tyr His Leu Met Ser His Thr

210 215 220Asp Leu Val Gln Gly Val Lys Tyr Pro Ile Gly Gly Phe Thr Ala Val225 230 235 240Val Asn Ala Leu His Gln Leu Ala Leu Glu Asn Gly Val Glu Phe Gln

245 250 255Leu Asp Ser Glu Val Ile Ser Ile Asn Thr Ala Ser Ser Arg Gly Asn

260 265 270Thr Ser Ala Thr Gly Val Ser Leu Leu His Asn Arg Lys Val Gln Asn

275 280 285Leu Asp Ala Asp Leu Val Val Ser Ala Gly Asp Leu His His Thr Glu

290 295 300Asn Asn Leu Leu Pro Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp305 310 315 320Ser Asn Arg Asn Pro Gly Ile Gly Ala Val Leu Ile Leu Leu Gly Val

325 330 335Lys Gly Glu Leu Pro Gln Leu Asp His His Asn Leu Phe Phe Ser Glu

340 345 350Asp Trp Thr Asp Asp Phe Ala Val Val Phe Asp Gly Pro Gln Leu Thr

355 360 365Arg Pro His Asn Ala Ser Asn Ser Ile Tyr Val Ser Lys Pro Ser Thr

370 375 380Ser Glu Asp Gly Val Ala Pro Ala Gly Tyr Glu Asn Leu Phe Val Leu385 390 395 400Ile Pro Thr Lys Ala Ser Ser Ser Ile Gly His Gly Asp Ala Tyr Met

405 410 415Gln Ser Ala Ser Ala Ser Val Glu Thr Ile Ala Ser His Ala Ile Asn

420 425 430Gln Ile Ala Thr Gln Ala Gly Ile Pro Asp Leu Thr Asp Arg Ile Val

435 440 445Val Lys Arg Thr Ile Gly Pro Ala Asp Phe Glu His Arg Tyr His Ser

450 455 460Trp Val Gly Ser Ala Leu Gly Pro Ala His Thr Leu Arg Gln Ser Ala465 470 475 480Phe Leu Arg Gly Arg Asn Ser Ser Arg Lys Val Asn Asn Leu Phe Tyr

485 490 495Ser Gly Ala Thr Thr Val Pro Gly Val Gly Ile Pro Met Cys Leu Ile

500 505 510Ser Ala Glu Asn Ile Ile Lys Arg Leu His Ala Asp Thr Ser Ala Gly

515 520 525Pro Leu Pro Glu Pro Leu Pro Pro Lys Thr Thr Pro Ser Gln Lys Thr

530535540 Ser Tyr Asp His545<210>263<211>1767<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1744)<223>FRXA00477<400>263tgcgggagcg aatcagagtt ccacttcata tcaaactctc tacactcgct agagccacga 60tgaaaggtct atctatgagc atctacagaa agaattcgtg atg aag gtc tcg act 115

Met Lys Val Ser Thr

1 5aaa act cca cgc tcc tca ggt acc gcc gta gtc ata ggc gca ggt gtt 163Lys Thr Pro Arg Ser Ser Gly Thr Ala Val Val Ile Gly Ala Gly Val

10 15 20gct ggt tta gcc act tct gca ctt tta gca cgt gat ggc tgg caa gta 211Ala Gly Leu Ala Thr Ser Ala Leu Leu Ala Arg Asp Gly Trp Gln Val

25 30 35act gtt ttg gaa aaa aat act gat gtc ggt ggc cga gct gga tcg ctt 259Thr Val Leu Glu Lys Asn Thr Asp Val Gly Gly Arg Ala Gly Ser Leu

40 45 50gaa ata tca ggc ttt cct ggc ttt cga tgg gat acc gga cct tct tgg 307Glu Ile Ser Gly Phe Pro Gly Phe Arg Trp Asp Thr Gly Pro Ser Trp

55 6065tac ctc atg ccc gag gcc ttt gac cat ttc ttc gca ctt ttt ggt gca 355Tyr Leu Met Pro Glu Ala Phe Asp His Phe Phe Ala Leu Phe Gly Ala 70 75 80 85tgt act tct gat tat ctc gat ttg gta gaa tta acg cct ggt tat cga 403Cys Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu Thr Pro Gly Tyr Arg

90 95 100gtt ttt tct ggc aca cat gac gct gtc gat gtc ccc act ggg cgt gaa 451Val Phe Ser Gly Thr His Asp Ala Val Asp Val Pro Thr Gly Arg Glu

105 110 115gaa gca att gcg cta ttc gaa tcc atc gaa ccc ggc gcg ggt gca aaa 499Glu Ala Ile Ala Leu Phe Glu Ser Ile Glu Pro Gly Ala Gly Ala Lys

120 125 130cta gga aat tat ctt gat agc gcg gca gac gcc tat gac att gcc att 547Leu Gly Asn Tyr Leu Asp Ser Ala Ala Asp Ala Tyr Asp Ile Ala Ile

135 140 145gat aga ttc ctt tat aat aat ttc tcc acg tta ggc ccg ctg ctt cac 595Asp Arg Phe Leu Tyr Asn Asn Phe Ser Thr Leu Gly Pro Leu Leu His150 155 160 165cgg gat gta ctg acc cga gct ggc cga ctg ttt tct cta ctg acc cgt 643Arg Asp Val Leu Thr Arg Ala Gly Arg Leu Phe Ser Leu Leu Thr Arg

170 175 180tct tta caa aag tac gta aat agt caa ttc agt agc ccg gtg ttg cgc 691Ser Leu Gln Lys Tyr Val Asn Ser Gln Phe Ser Ser Pro Val Leu Arg

185 190 195cag atc cra acc tat cca gca gtc ttc ctg tct tcc cga ccc act act 739Gln Ile Leu Thr Tyr Pro Ala Val Phe Leu Ser Ser Arg Pro Thr Thr

200 205 210acc cca tcg atg tac cac ttg atg agt cat acc gat ttg gtg cag gga 787Thr Pro Ser Met Tyr His LeuMet Ser His Thr Asp Leu Val Gln Gly

215 220 225gtg aaa tac cct ata ggt ggt ttt act gca gtg gtt aac gct ctg cat 835Val Lys Tyr Pro Ile Gly Gly Phe Thr Ala Val Val Asn Ala Leu His230 235 240 245cag tta gcg ctg gaa aac ggg gtt gag ttt caa ctc gat tct gag gtc 883Gln Leu Ala Leu Glu Asn Gly Val Glu Phe Gln Leu Asp Ser Glu Val

250 255 260att tcc atc aac act gct tca tcg agg ggc aac aca agc gcc aca ggt 931Ile Ser Ile Asn Thr Ala Ser Ser Arg Gly Asn Thr Ser Ala Thr Gly

265 270 275gtg agc ttg ctt cac aac aga aaa gtg caa aat cta gat gcg gat ctt 979Val Ser Leu Leu His Asn Arg Lys Val Gln Asn Leu Asp Ala Asp Leu

280 285 290gtg gtt tca gca ggc gac cta cac cat aca gaa aat aat ctg ctt ccc 1027Val Val Ser Ala Gly Asp Leu His His Thr Glu Asn Asn Leu Leu Pro

295 300 305cgg gaa ctt cga acc tat ccc gaa cga tat tgg tcc aat cgc aat cct 1075Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp Ser Asn Arg Asn Pro310 315 320 325gga att gga gcg gta tta atc ctc ctg ggc gta aaa gga gag tta ccc 1123Gly Ile Gly Ala Val Leu Ile Leu Leu Gly Val Lys Gly Glu Leu Pro

330 335 340cag ctc gac cat cac aac ctt ttc ttc agt gaa gat tgg aca gat gat 1171Gln Leu Asp His His Asn Leu Phe Phe Ser Glu Asp Trp Thr Asp Asp

345 350 355ttt gct gta gtt ttc gac ggg cct caa ctt acc cgc ccc cac aat gca 1219Phe Ala Val Val Phe Asp Gly Pro Gln Leu Thr Arg Pro His Asn Ala

360 365370tca aat tcc att tat gtc tcc aag cct tca acg tcc gaa gac ggc gtt 1267Ser Asn Ser Ile Tyr Val Ser Lys Pro Ser Thr Ser Glu Asp Gly Val

375 380 385gca cct gct gga tac gaa aac ctt ttt gtt tta att ccg acc aag gcc 1315Ala Pro Ala Gly Tyr Glu Asn Leu Phe Val Leu Ile Pro Thr Lys Ala390 395 400 405tct agc agc atc ggc cac ggt gat gcg tat atg cag tcg gct tca gca 1363Ser Ser Ser Ile Gly His Gly Asp Ala Tyr Met Gln Ser Ala Ser Ala

410 415 420tcc gtg gaa aca atc gcg tca cat gca atc aat caa att gct acg caa 1411Ser Val Glu Thr Ile Ala Ser His Ala Ile Asn Gln Ile Ala Thr Gln

425 430 435gcc ggc atc cct gac ctc act gac cga att gtg gtc aaa cgc acc att 1459Ala Gly Ile Pro Asp Leu Thr Asp Arg Ile Val Val Lys Arg Thr Ile

440 445 450ggc cct gcg gat ttt gag cac cgc tac cat tca tgg gta ggc agt gcg 1507Gly Pro Ala Asp Phe Glu His Arg Tyr His Ser Trp Val Gly Ser Ala

455 460 465ctg ggt cca gca cat acc ctc aga cag tcc gct ttc tta aga ggg cgc 1555Leu Gly Pro Ala His Thr Leu Arg Gln Ser Ala Phe Leu Arg Gly Arg470 475 480 485aat agc tcc cgc aag gtc aat aac ctc ttc tat tcc ggt gcc acc acc 1603Asn Ser Ser Arg Lys Val Asn Asn Leu Phe Tyr Ser Gly Ala Thr Thr

490 495 500gtc ccg ggt gta gga ata ccc atg tgt tta att tct gcc gag aat att 1651Val Pro Gly Val Gly Ile Pro Met Cys Leu Ile Ser Ala Glu Asn Ile

505 510 515att aag cgt tta cat gcc gat acc agt gca gga cca ctg ccc gaa cca 1699Ile Lys Arg Leu HisAla Asp Thr Ser Ala Gly Pro Leu Pro Glu Pro

520 525 530ttg ccg cct aaa acg aca cca tct caa aag acc tca tac gat cat 1744Leu Pro Pro Lys Thr Thr Pro Ser Gln Lys Thr Ser Tyr Asp His

535540545 taaattttga tccctatcat cga 1767<210>264<211>548<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>264Met Lys Val Ser Thr Lys Thr Pro Arg Ser Ser Gly Thr Ala Val Val 151015 Ile Gly Ala Gly Val Ala Gly Leu Ala Thr Ser Ala Leu Leu Ala Arg

20 25 30Asp Gly Trp Gln Val Thr Val Leu Glu Lys Asn Thr Asp Val Gly Gly

35 40 45Arg Ala Gly Ser Leu Glu Ile Ser Gly Phe Pro Gly Phe Arg Trp Asp

50 55 60Thr Gly Pro Ser Trp Tyr Leu Met Pro Glu Ala Phe Asp His Phe Phe 65 70 75 80Ala Leu Phe Gly Ala Cys Thr Ser Asp Tyr Leu Asp Leu Val Glu Leu

85 90 95Thr Pro Gly Tyr Arg Val Phe Ser Gly Thr His Asp Ala Val Asp Val

100 105 110Pro Thr Gly Arg Glu Glu Ala Ile Ala Leu Phe Glu Ser Ile Glu Pro

115 120 125Gly Ala Gly Ala Lys Leu Gly Asn Tyr Leu Asp Ser Ala Ala Asp Ala

130 135 140Tyr Asp Ile Ala Ile Asp Arg Phe Leu Tyr Asn Asn Phe Ser Thr Leu145 150 155 160Gly Pro Leu Leu His Arg Asp Val Leu Thr Arg Ala Gly Arg Leu Phe

165 170 175Ser Leu Leu Thr Arg Ser Leu Gln Lys Tyr Val Asn Ser Gln Phe Ser

180 185 190Ser Pro Val Leu Arg Gln Ile Leu Thr Tyr Pro Ala Val Phe Leu Ser

195 200 205Ser Arg Pro Thr Thr Thr Pro Ser Met Tyr His Leu Met Ser His Thr

210 215 220Asp Leu Val Gln Gly Val Lys Tyr Pro Ile Gly Gly Phe Thr Ala Val225 230 235 240Val Asn Ala Leu His Gln Leu Ala Leu Glu Asn Gly Val Glu Phe Gln

245 250 255Leu Asp Ser Glu Val Ile Ser Ile Asn Thr Ala Ser Ser Arg Gly Asn

260 265 270Thr Ser Ala Thr Gly Val Ser Leu Leu His Asn Arg Lys Val Gln Asn

275 280 285Leu Asp Ala Asp Leu Val Val Ser Ala Gly Asp Leu His His Thr Glu

290 295 300Asn Asn Leu Leu Pro Arg Glu Leu Arg Thr Tyr Pro Glu Arg Tyr Trp305 310 315 320Ser Asn Arg Asn Pro Gly Ile Gly Ala Val Leu Ile Leu Leu Gly Val

325 330 335Lys Gly Glu Leu Pro Gln Leu Asp His His Asn Leu Phe Phe Ser Glu

340 345 350Asp Trp Thr Asp Asp Phe Ala Val Val Phe Asp Gly Pro Gln Leu Thr

355 360 365Arg Pro His Asn Ala Ser Asn Ser Ile Tyr Val Ser Lys Pro Ser Thr

370 375 380Ser Glu Asp Gly Val Ala Pro Ala Gly Tyr Glu Asn Leu Phe Val Leu385 390 395 400Ile Pro Thr Lys Ala Ser Ser Ser Ile Gly His Gly Asp Ala Tyr Met

405 410 415Gln Ser Ala Ser Ala Ser Val Glu Thr Ile Ala Ser His Ala Ile Asn

420 425 430Gln Ile Ala Thr Gln Ala Gly Ile Pro Asp Leu Thr Asp Arg Ile Val

435 440 445Val Lys Arg Thr Ile Gly Pro Ala Asp Phe Glu His Arg Tyr His Ser

450 455 460Trp Val Gly Ser Ala Leu Gly Pro Ala His Thr Leu Arg Gln Ser Ala465 470 475 480Phe Leu Arg Gly Arg Asn Ser Ser Arg Lys Val Asn Asn Leu Phe Tyr

485 490 495Ser Gly Ala Thr Thr Val Pro Gly Val Gly Ile Pro Met Cys Leu Ile

500 505 510Ser Ala Glu Asn Ile Ile Lys Arg Leu His Ala Asp Thr Ser Ala Gly

515 520 525Pro Leu Pro Glu Pro Leu Pro Pro Lys Thr Thr Pro Ser Gln Lys Thr

530535540 Ser Tyr Asp His545<210>265<211>954<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (931)<223>RXA00478<400>265accagaagca gcctcagcta tgacacacca aaattcgcct ctcttcctta aaagtgcact 60gagactttac aatcgggcct cattcaaggc ttcacataaa gtg atc gaa gaa tat 115

Val Ile Glu Glu Tyr

1 5tcc acg agc ttc agt ctg tct acg tgg ttg cta tcc cca cgc ata cga 163Ser Thr Ser Phe Ser Leu Ser Thr Trp Leu Leu Ser Pro Arg Ile Arg

10 15 20aat gac ata cga aat ctc tat gca gta gtt cgt atc gcc gat gag att 211Asn Asp Ile Arg Asn Leu Tyr Ala Val Val Arg Ile Ala Asp Glu Ile

25 30 35gtc gac ggc act gca cat gcc gct ggt tgc tca act gcc aaa atc gaa 259Val Asp Gly Thr Ala His Ala Ala Gly Cys Ser Thr Ala Lys Ile Glu

40 45 50gag att ctc gat gcc tat gaa att gcg gtt ctt gca gca cca caa caa 307Glu Ile Leu Asp Ala Tyr Glu Ile Ala Val Leu Ala Ala Pro Gln Gln

55 60 65cgc ttc aac aca gat ctt gtt tta caa gct tat ggt gaa act gcc cga 355Arg Phe Asn Thr Asp Leu Val Leu Gln Ala Tyr Gly Glu Thr Ala Arg 70 75 80 85cgc tgt gat ttc gaa caa gag cat gta ata gcc ttc ttt gca tca atg 403Arg Cys Asp Phe Glu Gln Glu His Val Ile Ala Phe Phe Ala Ser Met

90 95 100cgt aag gac ctc aaa gct aat aca cac gac cca gat agc ttc aca acg 451Arg Lys Asp Leu Lys Ala Asn Thr His Asp Pro Asp Ser Phe Thr Thr

105 110 115tat gtc tat ggc tcc gcg gaa gtt ata ggc ctg ctt tgt ctc agc gtt 499Tyr Val Tyr Gly Ser Ala Glu Val Ile Gly Leu Leu Cys Leu Ser Val

120 125 130ttc aac caa ggt aga acg att agc aaa aaa cgg cta gag att atg caa 547Phe Asn Gln Gly Arg Thr Ile Ser Lys Lys Arg Leu Glu Ile Met Gln

135 140 145aac gga gcc cgc tca ttg gga gcg gca ttc cag aaa att aac ttt ctc 595Asn Gly Ala Arg Ser Leu Gly Ala Ala Phe Gln Lys Ile Asn Phe Leu150 155 160 165cgt gac ttg gca gaa gat cag caa aat ttg ggc cga ttt tat ttc ccc 643Arg Asp Leu Ala Glu Asp Gln Gln Asn Leu Gly Arg Phe Tyr Phe Pro

170175 180aaa acc agc caa gga act ctt act aaa gaa caa aaa gaa gat ctc atc 691Lys Thr Ser Gln Gly Thr Leu Thr Lys Glu Gln Lys Glu Asp Leu Ile

185 190 195gct gat atc cgt caa gac cta gca att gcc cac gat gca ttt cca gaa 739Ala Asp Ile Arg Gln Asp Leu Ala Ile Ala His Asp Ala Phe Pro Glu

200 205 210ata cca gtg cag gct cgc atc gga gtg atc tct gct tat ttg ctc ttt 787Ile Pro Val Gln Ala Arg Ile Gly Val Ile Ser Ala Tyr Leu Leu Phe

215 220 225caa aaa ctc act gac cga att gag gct act cct acc gcc gat tta ttg 835Gln Lys Leu Thr Asp Arg Ile Glu Ala Thr Pro Thr Ala Asp Leu Leu230 235 240 245cgg gag cga atc aga gtt cca ctt cat atc aaa ctc tct aca ctc gct 883Arg Glu Arg Ile Arg Val Pro Leu His Ile Lys Leu Ser Thr Leu Ala

250 255 260aga gcc acg atg aaa ggt cta tct atg agc atc tac aga aag aat tcg 931Arg Ala Thr Met Lys Gly Leu Ser Met Ser Ile Tyr Arg Lys Asn Ser

265270275 tgatgaaggt ctcgactaaa act 954<210>266<211>277<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>266Val Ile Glu Glu Tyr Ser Thr Ser Phe Ser Leu Ser Thr Trp Leu Leu 151015 Ser Pro Arg Ile Arg Asn Asp Ile Arg Asn Leu Tyr Ala Val Val Arg

20 25 30Ile Ala Asp Glu Ile Val Asp Gly Thr Ala His Ala Ala Gly Cys Ser

35 40 45Thr Ala Lys Ile Glu Glu Ile Leu Asp Ala Tyr Glu Ile Ala Val Leu

50 55 60Ala Ala Pro Gln Gln Arg Phe Asn Thr Asp Leu Val Leu Gln Ala Tyr65 7075 80Gly Glu Thr Ala Arg Arg Cys Asp Phe Glu Gln Glu His Val Ile Ala

85 90 95Phe Phe Ala Ser Met Arg Lys Asp Leu Lys Ala Asn Thr His Asp Pro

100 105 110Asp Ser Phe Thr Thr Tyr Val Tyr Gly Ser Ala Glu Val Ile Gly Leu

115 120 125Leu Cys Leu Ser Val Phe Asn Gln Gly Arg Thr Ile Ser Lys Lys Arg

130 135 140Leu Glu Ile Met Gln Asn Gly Ala Arg Ser Leu Gly Ala Ala Phe Gln145 l50 155 160Lys Ile Asn Phe Leu Arg Asp Leu Ala Glu Asp Gln Gln Asn Leu Gly

165 170 175Arg Phe Tyr Phe Pro Lys Thr Ser Gln Gly Thr Leu Thr Lys Glu Gln

180 185 190Lys Glu Asp Leu Ile Ala Asp Ile Arg Gln Asp Leu Ala Ile Ala His

195 200 205Asp Ala Phe Pro Glu Ile Pro Val Gln Ala Arg Ile Gly Val Ile Ser

210 215 220Ala Tyr Leu Leu Phe Gln Lys Leu Thr Asp Arg Ile Glu Ala Thr Pro225 230 235 240Thr Ala Asp Leu Leu Arg Glu Arg Ile Arg Val Pro Leu His Ile Lys

245 250 255Leu Ser Thr Leu Ala Arg Ala Thr Met Lys Gly Leu Ser Met Ser Ile

260 265 270Tyr Arg Lys Asn Ser

275<210>267<211>1056<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1033)<223>RXA01291<400>267aacccgcagc gggtggagcg gggctgaggg agacgtcgag aagcgtccct ttcggttgtc 60tggatttctc gcggtaaagt ttcctgtgaa ggaggcgagt gtg gct gat cag caa 115

Val Ala Asp Gln Gln

1 5gat ttt ttg ggc cgt ttt gat gcg atg agc tca aag gcg acg gcc acg 163Asp Phe Leu Gly Arg Phe Asp Ala Met Ser Ser Lys Ala Thr Ala Thr

10 15 20gta atc gcc cat tat tcc tcc agt ttt act ctg gca tcg aag ctg ttg 211Val Ile Ala His Tyr Ser Ser Ser Phe Thr Leu Ala Ser Lys Leu Leu

25 30 35tcg ccg aaa att cgt cgc gat att gag gca ttg tac gca atg gtg cga 259Ser Pro Lys Ile Arg Arg Asp Ile Glu Ala Leu Tyr Ala Met Val Arg

40 45 50gtg gcc gat gag gtt gtg gac ggc gct gct gct gcc gcg ggg tgt gcg 307Val Ala Asp Glu Val Val Asp Gly Ala Ala Ala Ala Ala Gly Cys Ala

55 60 65ccg gac gcc gtt gcg gag att ttg gac aat tac gaa cgc cag gtt ctg 355Pro Asp Ala Val Ala Glu Ile Leu Asp Asn Tyr Glu Arg Gln Val Leu 70 75 80 85ctc agt ttg tcc gtt cct ttt cat acc gat cca gtg atc cat gcg ttt 403Leu Ser Leu Ser Val Pro Phe His Thr Asp Pro Val Ile His Ala Phe

90 95 100ggc aat acc gcc cgc aaa tgt ggt ttt gag cag gct cac atc gtg gcg 451Gly Asn Thr Ala Arg Lys Cys Gly Phe Glu Gln Ala His Ile Val Ala

105 110 115ttt ttt gat tcc atg cgc cgc gat ctc tcc caa acc tcc tat gat ccg 499Phe Phe Asp Ser Met Arg Arg Asp Leu Ser Gln Thr Ser Tyr Asp Pro

120 125130act cag ttg gat gag tac att tac ggc tcc gct gag gtc atc ggg ttg 547Thr Gln Leu Asp Glu Tyr Ile Tyr Gly Ser Ala Glu Val Ile Gly Leu

135 140 145atg tgt ttg aaa att ttc ctc caa gat tcc act gcc agc ccg cag gat 595Met Cys Leu Lys Ile Phe Leu Gln Asp Ser Thr Ala Ser Pro Gln Asp150 155 160 165cgg gcc acg atg gaa cac ggc gcc agg cgt ttg ggt gcg gca ttt caa 643Arg Ala Thr Met Glu His Gly Ala Arg Arg Leu Gly Ala Ala Phe Gln

170 175 180aag gta aat ttc ctg cga gat cta gct gaa gac cgc gaa ggc cta ggc 691Lys Val Asn Phe Leu Arg Asp Leu Ala Glu Asp Arg Glu Gly Leu Gly

185 190 195cgt tct tat ttg ccg gta ttc acc gaa gaa atg cgc gat gag atc gtt 739Arg Ser Tyr Leu Pro Val Phe Thr Glu Glu Met Arg Asp Glu Ile Val

200 205 210act gat atc cga gag gat ttg gat gcc gcc cgg ctg agc att ccg ctg 787Thr Asp Ile Arg Glu Asp Leu Asp Ala Ala Arg Leu Ser Ile Pro Leu

215 220 225ctg cca ttt ggc gcg cga acc ggt gtg cgc gcc gcg acc gat ctc tac 835Leu Pro Phe Gly Ala Arg Thr Gly Val Arg Ala Ala Thr Asp Leu Tyr230 235 240 245ggt tgc ctc gtg gac aac ctg gaa tcc gcg tcc ctc gaa gac tta aaa 883Gly Cys Leu Val Asp Asn Leu Glu Ser Ala Ser Leu Glu Asp Leu Lys

250 255 260aac ggg cgg gat ttt gtg ccg tct tta aaa aag cca gcc tgg caa cca 931Asn Gly Arg Asp Phe Val Pro Ser Leu Lys Lys Pro Ala Trp Gln Pro

265 270 275aag caa tgt gga aag aag tgt ttc aaa aat gac aaa agc agt ggt cat 979Lys Gln Cys Gly Lys Lys Cys Phe Lys Asn Asp Lys Ser Ser Gly His

280 285 290cgg cgg ggg act agc agg act agc cac cac cgc act gct ctt acg cga 1027Arg Arg Gly Thr Ser Arg Thr Ser His His Arg Thr Ala Leu Thr Arg

295300305 agg ata tgaagtccac ctcgtcgaac aaa 1056Arg 310<210>268<211>311<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>268Val Ala Asp Gln Gln Asp Phe Leu Gly Arg Phe Asp Ala Met Ser Ser 151015 Lys Ala Thr Ala Thr Val Ile Ala His Tyr Ser Ser Ser Phe Thr Leu

20 25 30Ala Ser Lys Leu Leu Ser Pro Lys Ile Arg Arg Asp Ile Glu Ala Leu

35 40 45Tyr Ala Met Val Arg Val Ala Asp Glu Val Val Asp Gly Ala Ala Ala

50 55 60Ala Ala Gly Cys Ala Pro Asp Ala Val Ala Glu Ile Leu Asp Asn Tyr 65 70 75 80Glu Arg Gln Val Leu Leu Ser Leu Ser Val Pro Phe His Thr Asp Pro

85 90 95Val Ile His Ala Phe Gly Asn Thr Ala Arg Lys Cys Gly Phe Glu Gln

100 105 110Ala His Ile Val Ala Phe Phe Asp Ser Met Arg Arg Asp Leu Ser Gln

115 120 125Thr Ser Tyr Asp Pro Thr Gln Leu Asp Glu Tyr Ile Tyr Gly Ser Ala

130 135 140Glu Val Ile Gly Leu Met Cys Leu Lys Ile Phe Leu Gln Asp Ser Thr145 150 155 160Ala Ser Pro Gln Asp Arg Ala Thr Met Glu His Gly Ala Arg Arg Leu

165 170 175Gly Ala Ala Phe Gln Lys Val Asn Phe Leu ArgAsp Leu Ala Glu Asp

180 185 190Arg Glu Gly Leu Gly Arg Ser Tyr Leu Pro Val Phe Thr Glu Glu Met

195 200 205Arg Asp Glu Ile Val Thr Asp Ile Arg Glu Asp Leu Asp Ala Ala Arg

210 215 220Leu Ser Ile Pro Leu Leu Pro Phe Gly Ala Arg Thr Gly Val Arg Ala225 230 235 240Ala Thr Asp Leu Tyr Gly Cys Leu Val Asp Asn Leu Glu Ser Ala Ser

245 250 255Leu Glu Asp Leu Lys Asn Gly Arg Asp Phe Val Pro Ser Leu Lys Lys

260 265 270Pro Ala Trp Gln Pro Lys Gln Cys Gly Lys Lys Cys Phe Lys Asn Asp

275 280 285Lys Ser Ser Gly His Arg Arg Gly Thr Ser Arg Thr Ser His His Arg

290295300 Thr Ala Leu Thr Arg Arg Ile 305310<210>269<211>1239<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1216)<223>RXA00480<400>269tttatggacc caaattcaca ctttctgtac ttcatcaaaa taaagcgcca tatacaacga 60ttgggaattt ttgcgagata actggccgtg tgatactcga atg gac aat ggc atg 115

Met Asp Asn Gly Met

1 5aca atc acc aca gaa cat tca act cat cct gat ctt gat ttc aat gat 163Thr Ile Thr Thr Glu His Ser Thr His Pro Asp Leu Asp Phe Asn Asp

10 15 20gag att tat cgg gaa cta aac cgc atc tgc gct tcg cta tct caa cag 211Glu Ile Tyr Arg Glu Leu Asn Arg Ile Cys Ala Ser Leu Ser Gln Gln

25 30 35tgc agc aca tat caa cca gag ttc cgt acc tgc cta gat gct gct ttc 259Cys Ser Thr Tyr Gln Pro Glu Phe Arg Thr Cys Leu Asp Ala Ala Phe

40 45 50caa gct ttg cga ggt ggc aag tta atc cgc cct cga atg cta ctg ggg 307Gln Ala Leu Arg Gly Gly Lys Leu Ile Arg Pro Arg Met Leu Leu Gly

55 60 65cta tac aac acg ctt gta gac gat gac att gag gtc aaa ctc aac acc 355Leu Tyr Asn Thr Leu Val Asp Asp Asp Ile Glu Val Lys Leu Asn Thr 70 75 80 85gtt tta cag gta gca gtg gct tta gaa cta ctg cat ttt tcc ctt ttg 403Val Leu Gln Val Ala Val Ala Leu Glu Leu Leu His Phe Ser Leu Leu

90 95 100gtt cat gac gat gtt att gac gga gac ctc tat cgc cga ggc aaa ctt 451Val His Asp Asp Val Ile Asp Gly Asp Leu Tyr Arg Arg Gly Lys Leu

105 110 115aat ttt att ggg cag att ctc atg cat cgc aca cct gaa agt ttt gca 499Asn Phe Ile Gly Gln Ile Leu Met His Arg Thr Pro Glu Ser Phe Ala

120 125 130caa atc cag cgc gat cca gag cat cta gat tgg gca caa tct aat gga 547Gln Ile Gln Arg Asp Pro Glu His Leu Asp Trp Ala Gln Ser Asn Gly

135 140 145ctg ctt atg gga aat ctt ttt ctt gct gcc acc cat caa atc ttc gcg 595Leu Leu Met Gly Asn Leu Phe Leu Ala Ala Thr His Gln Ile Phe Ala150 155 160 165cgc ctt gac ctt cca cat cac caa cgg gtt cga ctt tta gat tta ctc 643Arg Leu Asp Leu Pro His His Gln Arg Val Arg Leu Leu Asp Leu Leu

170 175 180aac cac acg ata aat gac act att gtg ggt gag ttt ctt gat gtg gga 691AsnHis Thr Ile Asn Asp Thr Ile Val Gly Glu Phe Leu Asp Val Gly

185 190 195tta agc agc aaa gcc atc agc ccc aat atg gac att gct cta gaa atg 739Leu Ser Ser Lys Ala Ile Ser Pro Asn Met Asp Ile Ala Leu Glu Met

200 205 210agt cgg cta aaa aca gcc aca tac act ttt gaa ctt cca atg aga gca 787Ser Arg Leu Lys Thr Ala Thr Tyr Thr Phe Glu Leu Pro Met Arg Ala

215 220 225gcg gca att ctc gcg gaa cta cct cag gag att gaa aca aag ata ggt 835Ala Ala Ile Leu Ala Glu Leu Pro Gln Glu Ile Glu Thr Lys Ile Gly230 235 240 245gag ata ggc aca aac ttg ggc atc gct tat caa ttg cag gac gat tac 883Glu Ile Gly Thr Asn Leu Gly Ile Ala Tyr Gln Leu Gln Asp Asp Tyr

250 255 260tta tct act ttt ggt gac gca gcc gaa cac ggc aaa gat gcc ttt tct 931Leu Ser Thr Phe Gly Asp Ala Ala Glu His Gly Lys Asp Ala Phe Ser

265 270 275gac ctt cga gaa gga aaa gaa act aca att atc gcc ttc gct cga gat 979Asp Leu Arg Glu Gly Lys Glu Thr Thr Ile Ile Ala Phe Ala Arg Asp

280 285 290act gct aaa tgg act gat att caa gac aac ttc ggc tcc gca gat ctg 1027Thr Ala Lys Trp Thr Asp Ile Gln Asp Asn Phe Gly Ser Ala Asp Leu

295 300 305agc acc tct cag gca gag cga att caa cat ctt ctc ata cag tgt gga 1075Ser Thr Ser Gln Ala Glu Arg Ile Gln His Leu Leu Ile Gln Cys Gly310 315 320 325gca aag aat cac tcc ttg aat gcc atc tcc gac cac tta aat atc tgc 1123Ala Lys Asn His Ser Leu Asn Ala Ile Ser Asp His Leu Asn Ile Cys

330335 340cgt tcg atg atc aaa aca cta agc ccc cag gta gat ccc aag gct caa 1171Arg Ser Met Ile Lys Thr Leu Ser Pro Gln Val Asp Pro Lys Ala Gln

345 350 355aat tta tta ctt aaa caa gtt gag caa cta gcc agc cgc aaa tct 1216Asn Leu Leu Leu Lys Gln Val Glu Gln Leu Ala Ser Arg Lys Ser

360365370 tagaactaac ctttacgcct tta 1239<210>270<211>372<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>270Met Asp Asn Gly Met Thr Ile Thr Thr Glu His Ser Thr His Pro Asp 151015 Leu Asp Phe Asn Asp Glu Ile Tyr Arg Glu Leu Asn Arg Ile Cys Ala

20 25 30Ser Leu Ser Gln Gln Cys Ser Thr Tyr Gln Pro Glu Phe Arg Thr Cys

35 40 45Leu Asp Ala Ala Phe Gln Ala Leu Arg Gly Gly Lys Leu Ile Arg Pro

50 55 60Arg Met Leu Leu Gly Leu Tyr Asn Thr Leu Val Asp Asp Asp Ile Glu65 70 75 80Val Lys Leu Asn Thr Val Leu Gln Val Ala Val Ala Leu Glu Leu Leu

85 90 95His Phe Ser Leu Leu Val His Asp Asp Val Ile Asp Gly Asp Leu Tyr

100 105 110Arg Arg Gly Lys Leu Asn Phe Ile Gly Gln Ile Leu Met His Arg Thr

115 120 125Pro Glu Ser Phe Ala Gln Ile Gln Arg Asp Pro Glu His Leu Asp Trp

130 135 140Ala Gln Ser Asn Gly Leu Leu Met Gly Asn Leu Phe Leu Ala Ala Thr145 150 155 160His Gln Ile Phe Ala Arg Leu Asp Leu Pro His His Gln Arg Val Arg

165 170 175Leu Leu Asp Leu Leu Asn His Thr Ile Asn Asp Thr Ile Val Gly Glu

180 185 190Phe Leu Asp Val Gly Leu Ser Ser Lys Ala Ile Ser Pro Asn Met Asp

195 200 205Ile Ala Leu Glu Met Ser Arg Leu Lys Thr Ala Thr Tyr Thr Phe Glu

210 215 220Leu Pro Met Arg Ala Ala Ala Ile Leu Ala Glu Leu Pro Gln Glu Ile225 230 235 240Glu Thr Lys Ile Gly Glu Ile Gly Thr Asn Leu Gly Ile Ala Tyr Gln

245 250 255Leu Gln Asp Asp Tyr Leu Ser Thr Phe Gly Asp Ala Ala Glu His Gly

260 265 270Lys Asp Ala Phe Ser Asp Leu Arg Glu Gly Lys Glu Thr Thr Ile Ile

275 280 285Ala Phe Ala Arg Asp Thr Ala Lys Trp Thr Asp Ile Gln Asp Asn Phe

290 295 300Gly Ser Ala Asp Leu Ser Thr Ser Gln Ala Glu Arg Ile Gln His Leu305 310 315 320Leu Ile Gln Cys Gly Ala Lys Asn His Ser Leu Asn Ala Ile Ser Asp

325 330 335His Leu Asn Ile Cys Arg Ser Met Ile Lys Thr Leu Ser Pro Gln Val

340 345 350Asp Pro Lys Ala Gln Asn Leu Leu Leu Lys Gln Val Glu Gln Leu Ala

355 360 365Ser Arg Lys Ser

370<210>271<211>1056<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1033)<223>RXS01879<400>271ctttgcgggc cgctgatatt gatccaacgc ttcgtggcga aaagcttgat gtcactgac 60atgtgcgcct agctggggtg ttgcagcaaa aggatgagaa gtg aaa att acc gct 115

Val Lys Ile Thr Ala

1 5aag gcg tgg gcg aaa acc aac ctg cat tta ggt gtg gga ccg gct cac 163Lys Ala Trp Ala Lys Thr Asn Leu His Leu Gly Val Gly Pro Ala His

10 15 20gac gat gga ttt cac gag ctc atg acg gtg ttt caa acc att gat ctg 211Asp Asp Gly Phe His Glu Leu Met Thr Val Phe Gln Thr Ile Asp Leu

25 30 35ttt gac acc gtc acc tta acc acc ctc gat gag gag ttg gtg gag gag 259Phe Asp Thr Val Thr Leu Thr Thr Leu Asp Glu Glu Leu Val Glu Glu

40 45 50ggg agc gtc gtc aag caa tta tct gtg acc ggt gcc cgt ggc gtg cct 307Gly Ser Val Val Lys Gln Leu Ser Val Thr Gly Ala Arg Gly Val Pro

55 60 65gag gac gcc agc aat ctt gcg tgg cgc gct gtg gat gcg ttg gtt aag 355Glu Asp Ala Ser Asn Leu Ala Trp Arg Ala Val Asp Ala Leu Val Lys 70 75 80 85cgg cgc gcg gaa aag acg ccg ctg tct gca gtt tcg ctg cat att tcc 403Arg Arg Ala Glu Lys Thr Pro Leu Ser Ala Val Ser Leu His Ile Ser

90 95 100aag ggg att ccg gtg gct ggc ggc atg gct ggc ggc tct gcg gat gcg 45lLys Gly Ile Pro Val Ala Gly Gly Met Ala Gly Gly Ser Ala Asp Ala

105 110 115gct gcg aca ctg cgc gca gtg gat gcc tgg att ggg cct ttc ggc gag 499Ala Ala Thr Leu Arg Ala Val Asp Ala Trp Ile Gly Pro Phe Gly Glu

120 125 130gac aca ttg ctg gag gtt gcc gcg gag ctc ggc tca gat gtg ccg ttt 547Asp Thr Leu Leu Glu Val Ala Ala Glu Leu Gly Ser Asp Val Pro Phe

135 140 145tgc ctg ctt ggt ggc acc atg cgc ggt acc ggt cgc ggc gag cag ctg 595Cys Leu Leu Gly Gly Thr Met Arg Gly Thr Gly Arg Gly Glu Gln Leu150 155 160 165gta gat atg ttg acg cgc ggc aag cta cat tgg gtg gtg gcc gcg atg 643Val Asp Met Leu Thr Arg Gly Lys Leu His Trp Val Val Ala Ala Met

170 175 180gcg cat ggc ctg tcc acg cct gag gta ttc aaa aag cat gat gag ctg 691Ala His Gly Leu Ser Thr Pro Glu Val Phe Lys Lys His Asp Glu Leu

185 190 195aat ccg gaa tcg cat atg gat atc agc gac ctc agc gcc gca ctt ctc 739Asn Pro Glu Ser His Met Asp Ile Ser Asp Leu Ser Ala Ala Leu Leu

200 205 210acc ggc aac acc gcc gag gtg ggg cag tgg ctg cac aat gat ctg acc 787Thr Gly Asn Thr Ala Glu Val Gly Gln Trp Leu His Asn Asp Leu Thr

215 220 225agc gcc gca ctc agt ttg cgc cct gaa ctg cgc agc gtc ctc caa gaa 835Ser Ala Ala Leu Ser Leu Arg Pro Glu Leu Arg Ser Val Leu Gln Glu230 235 240 245ggc atc cgc tcc ggc gcg cat gca gga att gtc tcc ggc tcc ggc ccg 883Gly Ile Arg Ser Gly Ala His Ala Gly Ile Val Ser Gly Ser Gly Pro

250 255 260acc acg gta ttc ttg tgc gaa tcg gag cac aaa gcg caa gac gtt aaa 931Thr Thr Val Phe Leu Cys Glu Ser Glu His Lys Ala Gln Asp Val Lys

265 270 275gag gcg cta atc gac gcc ggc cag gtg tac gct gct tac acc gcc acc 979Glu Ala Leu Ile Asp Ala Gly Gln Val Tyr Ala Ala Tyr Thr Ala Thr

280 285 290ggc cct gcg gcc tca acc gcc gac cag cgc ggc gca cac att ttg act 1027Gly Pro Ala Ala Ser Thr Ala Asp Gln Arg Gly Ala His Ile Leu Thr

295300305 gtt tca taataaagac aaacttaagt atc 1056Val Ser310<210>272<211>311<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>272Val Lys Ile Thr Ala Lys Ala Trp Ala Lys Thr Asn Leu His Leu Gly 151015 Val Gly Pro Ala His Asp Asp Gly Phe His Glu Leu Met Thr Val Phe

20 25 30Gln Thr Ile Asp Leu Phe Asp Thr Val Thr Leu Thr Thr Leu Asp Glu

35 40 45Glu Leu Val Glu Glu Gly Ser Val Val Lys Gln Leu Ser Val Thr Gly

50 55 60Ala Arg Gly Val Pro Glu Asp Ala Ser Asn Leu Ala Trp Arg Ala Val 65 70 75 80Asp Ala Leu Val Lys Arg Arg Ala Glu Lys Thr Pro Leu Ser Ala Val

85 90 95Ser Leu His Ile Ser Lys Gly Ile Pro Val Ala Gly Gly Met Ala Gly

100 105 110Gly Ser Ala Asp Ala Ala Ala Thr Leu Arg Ala Val Asp Ala Trp Ile

115 120 125Gly Pro Phe Gly Glu Asp Thr Leu Leu Glu Val Ala Ala Glu Leu Gly

130 135 140Ser Asp Val Pro Phe Cys Leu Leu Gly Gly Thr Met Arg Gly Thr Gly145 150 155 160Arg Gly Glu Gln Leu Val Asp Met Leu Thr Arg Gly Lys Leu His Trp

165 170 175Val Val Ala Ala Met Ala HisGly Leu Ser Thr Pro Glu Val Phe Lys

180 185 190Lys His Asp Glu Leu Asn Pro Glu Ser His Met Asp Ile Ser Asp Leu

195 200 205Ser Ala Ala Leu Leu Thr Gly Asn Thr Ala Glu Val Gly Gln Trp Leu

210 215 220His Asn Asp Leu Thr Ser Ala Ala Leu Ser Leu Arg Pro Glu Leu Arg225 230 235 240Ser Val Leu Gln Glu Gly Ile Arg Ser Gly Ala His Ala Gly Ile Val

245 250 255Ser Gly Ser Gly Pro Thr Thr Val Phe Leu Cys Glu Ser Glu His Lys

260 265 270Ala Gln Asp Val Lys Glu Ala Leu Ile Asp Ala Gly Gln Val Tyr Ala

275 280 285Ala Tyr Thr Ala Thr Gly Pro Ala Ala Ser Thr Ala Asp Gln Arg Gly

290295300 Ala His Ile Leu Thr Val Ser 305310<210>273<211>891<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (868)<223>RXS02023<400>273gatgtggcag caattttgaa gcagtacctg agcgagtaac cgcattcggg gttatcgtgg 60gacttccgaa atgtaactag agactagagg aggaaacacg atg gct cct aaa caa 115

Met Ala Pro Lys Gln

1 5act ccc agc cca gag aag aat cga aac ctg gtg gga cca gtt ctg caa 163Thr Pro Ser Pro Glu Lys Asn Arg Asn Leu Val Gly Pro Val Leu Gln

10 15 20cgt cgg cag aca gag ggt act ttt gat caa cgc ttg cta gaa atg cgc 211Arg Arg Gln Thr Glu Gly Thr Phe Asp Gln Arg Leu Leu Glu Met Arg

25 30 35gct gat cac aat tgg aag cac gcc gat cca tgg cgt gta ctg cgt att 259Ala Asp His Asn Trp Lys His Ala Asp Pro Trp Arg Val Leu Arg Ile

40 45 50cag tct gag ttt gtg gcg ggt ttt gat gcc ctc cac gag atg cca aag 307Gln Ser Glu Phe Val Ala Gly Phe Asp Ala Leu His Glu Met Pro Lys

55 60 65gcc gta acc gtc ttt ggt tcc gca cgc att aaa gag gat cac ccg tac 355Ala Val Thr Val Phe Gly Ser Ala Arg Ile Lys Glu Asp His Pro Tyr 70 75 80 85tac aag gcg ggt gta gaa ctt ggt gaa aag ctc gtt gca gcg gac tac 403Tyr Lys Ala Gly Val Glu Leu Gly Glu Lys Leu Val Ala Ala Asp Tyr

90 95 100gca gtt gtc acc ggt ggc ggt cca ggt ctg atg gaa gcc ccc aat aag 451Ala Val Val Thr Gly Gly Gly Pro Gly Leu Met Glu Ala Pro Asn Lys

105 110 115ggg gca agc gag gcc aat ggt tta tca gtt ggt ctg ggc att gag ttg 499Gly Ala Ser Glu Ala Asn Gly Leu Ser Val Gly Leu Gly Ile Glu Leu

120 125 130cca cat gaa cag cat ctg aac cct tat gtg gat ttg ggt ctg aac ttc 547Pro His Glu Gln His Leu Asn Pro Tyr Val Asp Leu Gly Leu Asn Phe

135 140 145cgg tac ttc ttc gca cgc aag acc atg ttc ctg aaa tac tcc cag gct 595Arg Tyr Phe Phe Ala Arg Lys Thr Met Phe Leu Lys Tyr Ser Gln Ala150 155 160 165ttt gtg tgt ctg cct ggt ggt ttc ggc acg ctc gat gag ctt ttc gag 643Phe Val Cys Leu Pro Gly Gly Phe Gly Thr Leu Asp Glu Leu Phe Glu

170 175 180gtc ctc tgc atg gta caaacc ggc aag gta ccc aac ttt ccc atc gtg 691Val Leu Cys Met Val Gln Thr Gly Lys Val Pro Asn Phe Pro Ile Val

185 190 195ctg atc ggc act gag ttc tgg gca ggt ttg gtg gat tgg atc cgt cac 739Leu Ile Gly Thr Glu Phe Trp Ala Gly Leu Val Asp Trp Ile Arg His

200 205 210cgc ctg gta gag gaa ggc atg atc gat gag aag gat gtt gac cgg atg 787Arg Leu Val Glu Glu Gly Met Ile Asp Glu Lys Asp Val Asp Arg Met

215 220 225ttg gtc act gat gac ctg gat cag gcc gtc aaa ttc atc gtc gat gca 835Leu Val Thr Asp Asp Leu Asp Gln Ala Val Lys Phe Ile Val Asp Ala230 235 240 245cac gct gga ttg gac gta gcg cgt ctc cac aat taagcagtgg ctacattagg 888His Ala Gly Leu Asp Val Ala Arg Leu His Asn

250255 tgt 891<210>274<211>256<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>274Met Ala Pro Lys Gln Thr Pro Ser Pro Glu Lys Asn Arg Asn Leu Val 151015 Gly Pro Val Leu Gln Arg Arg Gln Thr Glu Gly Thr Phe Asp Gln Arg

20 25 30Leu Leu Glu Met Arg Ala Asp His Asn Trp Lys His Ala Asp Pro Trp

35 40 45Arg Val Leu Arg Ile Gln Ser Glu Phe Val Ala Gly Phe Asp Ala Leu

50 55 60His Glu Met Pro Lys Ala Val Thr Val Phe Gly Ser Ala Arg Ile Lys 65 70 75 80Glu Asp His Pro Tyr Tyr Lys Ala Gly Val Glu Leu Gly Glu Lys Leu

85 90 95Val Ala Ala Asp Tyr Ala Val Val Thr Gly Gly Gly Pro Gly Leu Met

100 105 110Glu Ala Pro Asn Lys Gly Ala Ser Glu Ala Asn Gly Leu Ser Val Gly

115 120 125Leu Gly Ile Glu Leu Pro His Glu Gln His Leu Asn Pro Tyr Val Asp

130 135 140Leu Gly Leu Asn Phe Arg Tyr Phe Phe Ala Arg Lys Thr Met Phe Leu145 150 155 160Lys Tyr Ser Gln Ala Phe Val Cys Leu Pro Gly Gly Phe Gly Thr Leu

165 170 175Asp Glu Leu Phe Glu Val Leu Cys Met Val Gln Thr Gly Lys Val Pro

180 185 190Asn Phe Pro Ile Val Leu Ile Gly Thr Glu Phe Trp Ala Gly Leu Val

195 200 205Asp Trp Ile Arg His Arg Leu Val Glu Glu Gly Met Ile Asp Glu Lys

210 215 220Asp Val Asp Arg Met Leu Val Thr Asp Asp Leu Asp Gln Ala Val Lys225 230 235 240Phe Ile Val Asp Ala His Ala Gly Leu Asp Val Ala Arg Leu His Asn

245250255<210>275<211>1242<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1219)<223>RXS00948<400>275acaccctcca aatgatctcg taaaacagta ttgaatttag gtacgactct aatcgtacct 60tgccctcaag ccaagctagt tgtacgatca aactcgttgt atg gca aac gtc gta 115

Met Ala Asn Val Val

1 5cta gtc gat cga atg gag cct ttg gtg tcc aag ctg ttt acc cca att 163Leu Val Asp Arg Met Glu Pro Leu Val Ser Lys Leu Phe Thr Pro Ile

10 15 20caa atc cgc gac atc acc atc ccc aac cgc gtg tgg atg tca ccg atg 211Gln Ile Arg Asp Ile Thr Ile Pro Asn Arg Val Trp Met Ser Pro Met

25 30 35tgc acc tac tct gca gcc acc ggt tca ggt ctt ccc acc gat ttt cac 259Cys Thr Tyr Ser Ala Ala Thr Gly Ser Gly Leu Pro Thr Asp Phe His

40 45 50cag gct cat tac gca gct cgc gca gca ggt ggt gtc gga tta gtc atg 307Gln Ala His Tyr Ala Ala Arg Ala Ala Gly Gly Val Gly Leu Val Met

55 60 65gtt gaa gca act gga gtg aac ccc gta gct ccc atc tcc cca gtc gac 355Val Glu Ala Thr Gly Val Asn Pro Val Ala Pro Ile Ser Pro Val Asp 70 75 80 85ctt gga ctt tgg agc cat gac caa att gaa cca ttc tcc cga gtg aca 403Leu Gly Leu Trp Ser His Asp Gln Ile Glu Pro Phe Ser Arg Val Thr

90 95 100gca gct att cgc gcc ggt ggg gca gta ccg gcc gtt caa tta gcc cat 451Ala Ala Ile Arg Ala Gly Gly Ala Val Pro Ala Val Gln Leu Ala His

105 110 115gct ggc cgc aag gca tcc acc gat gct ccg tgg aat ggt ggc gga tat 499Ala Gly Arg Lys Ala Ser Thr Asp Ala Pro Trp Asn Gly Gly Gly Tyr

120 125 130gtt gga cca gaa acc aat gga tgg gag act gtc ggc ccc agc cct ctg 547Val Gly Pro Glu Thr Asn Gly Trp Glu Thr Val Gly Pro Ser Pro Leu

135 140 145gca ttc cca ggt ttg cct gct ccg cgc gag ctg acg gtt tca gaa atc 595Ala Phe Pro Gly Leu Pro Ala Pro Arg Glu Leu Thr Val Ser Glu Ile150 155 160 165caa gag gtt gtg cag cag ttc gct ggc gcc gcc gtt cgt gcc gat cag 643Gln Glu Val Val Gln Gln Phe Ala Gly Ala Ala Val Arg Ala Asp Gln

170 175 180gct ggt ttt gat gtc gtg gaa att cac gca gca cac ggc tac ctt ttg 691Ala Gly Phe Asp Val Val Glu Ile His Ala Ala His Gly Tyr Leu Leu

185 190 195cat aac ttc ctt tct ccg atc tcc aac aag cgc acc gat tca tac ggc 739His Asn Phe Leu Ser Pro Ile Ser Asn Lys Arg Thr Asp Ser Tyr Gly

200 205 210gga tct tta gaa aac cgc gct cgc atc gtg ctc gaa gtc att gat gca 787Gly Ser Leu Glu Asn Arg Ala Arg Ile Val Leu Glu Val Ile Asp Ala

215 220 225atc cgc gca gtg tgg cca gag gaa aag cct gta ttc atg cgc att tcc 835Ile Arg Ala Val Trp Pro Glu Glu Lys Pro Val Phe Met Arg Ile Ser230 235 240 245acc acc gac tgg gtg gag gaa aac cca cag gat gat cgc gag tcc tgg 883Thr Thr Asp Trp Val Glu Glu Asn Pro Gln Asp Asp Arg Glu Ser Trp

250 255 260acg ctg agc caa agc agg cag ctg gct ttg tgg gca tcc gag cac gga 931Thr Leu Ser Gln Ser Arg Gln Leu Ala Leu Trp Ala Ser Glu His Gly

265 270 275gtt gat ttg atc gat gcc tct tct ggt ggc ctc gac atc gtc ccc att 979Val Asp Leu Ile Asp Ala Ser Ser Gly Gly Leu Asp Ile Val Pro Ile

280 285 290ccg cat gac cgc gat tac caa acc gcg aag gcc gca gat ctt cac gca 1027Pro His Asp Arg Asp Tyr Gln Thr Ala Lys Ala Ala Asp Leu His Ala

295 300 305agt acc gga gtg aca gtc gct gct gtg ggg cgc att gat gac gcc caa 1075Ser Thr Gly Val Thr Val Ala Ala Val Gly Arg Ile Asp Asp Ala Gln310 315 320 325act gcg cac aat ttg gtt gat tct ggc gat gtcaat gca gtt ttc ctc 1123Thr Ala His Asn Leu Val Asp Ser Gly Asp Val Asn Ala Val Phe Leu

330 335 340ggc cgt cca ctg ctc aag gat cct tcc tgg gca aac caa gca gcc ctc 1171Gly Arg Pro Leu Leu Lys Asp Pro Ser Trp Ala Asn Gln Ala Ala Leu

345 350 355gca cta ggt gcg gaa ccc agg tat gtt cac caa tac gac tac gta ctt 1219Ala Leu Gly Ala Glu Pro Arg Tyr Val His Gln Tyr Asp Tyr Val Leu

360365370 taaaggagag ttgacatgaa ggt 1242<210>276<211>373<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>276Met Ala Asn Val Val Leu Val Asp Arg Met Glu Pro Leu Val Ser Lys 151015 Leu Phe Thr Pro Ile Gln Ile Arg Asp Ile Thr Ile Pro Asn Arg Val

20 25 30Trp Met Ser Pro Met Cys Thr Tyr Ser Ala Ala Thr Gly Ser Gly Leu

35 40 45Pro Thr Asp Phe His Gln Ala His Tyr Ala Ala Arg Ala Ala Gly Gly

50 55 60Val Gly Leu Val Met Val Glu Ala Thr Gly Val Asn Pro Val Ala Pro 65 70 75 80Ile Ser Pro Val Asp Leu Gly Leu Trp Ser His Asp Gln Ile Glu Pro

85 90 95Phe Ser Arg Val Thr Ala Ala Ile Arg Ala Gly Gly Ala Val Pro Ala

100 105 110Val Gln Leu Ala His Ala Gly Arg Lys Ala Ser Thr Asp Ala Pro Trp

115 120 125Asn Gly Gly Gly Tyr Val Gly Pro Glu Thr Asn Gly Trp Glu Thr Val

130 135 140Gly Pro Ser Pro Leu Ala Phe Pro Gly Leu Pro Ala Pro Arg Glu Leu145 150 155 160Thr Val Ser Glu Ile Gln Glu Val Val Gln Gln Phe Ala Gly Ala Ala

165 170 175Val Arg Ala Asp Gln Ala Gly Phe Asp Val Val Glu Ile His Ala Ala

180 185 190His Gly Tyr Leu Leu His Asn Phe Leu Ser Pro Ile Ser Asn Lys Arg

195 200 205Thr Asp Ser Tyr Gly Gly Ser Leu Glu Asn Arg Ala Arg Ile Val Leu

210 215 220Glu Val Ile Asp Ala Ile Arg Ala Val Trp Pro Glu Glu Lys Pro Val225 230 235 240Phe Met Arg Ile Ser Thr Thr Asp Trp Val Glu Glu Asn Pro Gln Asp

245 250 255Asp Arg Glu Ser Trp Thr Leu Ser Gln Ser Arg Gln Leu Ala Leu Trp

260 265 270Ala Ser Glu His Gly Val Asp Leu Ile Asp Ala Ser Ser Gly Gly Leu

275 280 285Asp Ile Val Pro Ile Pro His Asp Arg Asp Tyr Gln Thr Ala Lys Ala

290 295 300Ala Asp Leu His Ala Ser Thr Gly Val Thr Val Ala Ala Val Gly Arg305 310 315 320Ile Asp Asp Ala Gln Thr Ala His Asn Leu Val Asp Ser Gly Asp Val

325 330 335Asn Ala Val Phe Leu Gly Arg Pro Leu Leu Lys Asp Pro Ser Trp Ala

340 345 350Asn Gln Ala Ala Leu Ala Leu Gly Ala Glu Pro Arg Tyr Val His Gln

355 360 365Tyr Asp Tyr Val Leu

370<210>277<211>1026<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1003)<223>RXS02228<400>277acagaagcgt caactgctca acttctcgac agcgacgaca cacacggcgt gggacgctac 60gttgctcgct ggacttttta acttaaggga gatctagatc gtg gta aca ccg atc 115

Val Val Thr Pro Ile

1 5gca gtg gtt gga ccc act gca tct gga aaa tca gct ttg gga att gct 163Ala Val Val Gly Pro Thr Ala Ser Gly Lys Ser Ala Leu Gly Ile Ala

10 15 20cta gcc cac aag ctt gac ggt gaa gta gtc aat gtg gat tcc atg cag 211Leu Ala His Lys Leu Asp Gly Glu Val Val Asn Val Asp Ser Met Gln

25 30 35ctg tac aaa ggc atg gac atc ggc acg gca aag ctg act gtc gaa gaa 259Leu Tyr Lys Gly Met Asp Ile Gly Thr Ala Lys Leu Thr Val Glu Glu

40 45 50cgc gaa ggc att gcg cat cat cag ctc gat gtc tgg gac gtt acc gaa 307Arg Glu Gly Ile Ala His His Gln Leu Asp Val Trp Asp Val Thr Glu

55 60 65act gcg tca gtg gcg agg ttt caa tcc gac gcc gtt gcc gat gtg gaa 355Thr Ala Ser Val Ala Arg Phe Gln Ser Asp Ala Val Ala Asp Val Glu 70 75 80 85gat att atg tcc cgt ggc aaa acc ccc atc ttg gtt ggc ggc tcc atg 403Asp Ile Met Ser Arg Gly Lys Thr Pro Ile Leu Val Gly Gly Ser Met

90 95 100ttg tac gtc caa tct ttg gtc gat gat tgg caa ttc cca cct acc gac 451Leu Tyr Val Gln Ser Leu Val Asp Asp Trp Gln Phe Pro Pro Thr Asp

105 110 115agc gct gtt cgc gca cgc ttt gag gcc cgc ttg gca gac atc ggt gtc 499Ser Ala Val Arg Ala Arg Phe Glu Ala Arg Leu Ala Asp Ile Gly Val

120 125 130gaa gca cta cac gct gaa ctt act cag ctt gac cca gaa gca gca gcc 547Glu Ala Leu His Ala Glu Leu Thr Gln Leu Asp Pro Glu Ala Ala Ala

135 140 145gtc atc gaa agc aat gat ccc cga cgc acc gtc cga gca tta gaa gtc 595Val Ile Glu Ser Asn Asp Pro Arg Arg Thr Val Arg Ala Leu Glu Val150 155 160 165att gaa cta acc ggc cag ccc ttc caa gca agc caa ccg ccc aaa gac 643Ile Glu Leu Thr Gly Gln Pro Phe Gln Ala Ser Gln Pro Pro Lys Asp

170 175 180gcg cca cct cgc tgg gga act cga atc att ggc ctg aaa acc act cca 691Ala Pro Pro Arg Trp Gly Thr Arg Ile Ile Gly Leu Lys Thr Thr Pro

185 190 195gaa tgg cta aat cca cgc atc gag cag cgc acc gcc agg atg ttt gaa 739Glu Trp Leu Asn Pro Arg Ile Glu Gln Arg Thr Ala Arg Met Phe Glu

200 205 210caa ggc ttt gtc gcc gaa gtg gaa cac ctt gtg cag caa gga ctc atc 787Gln Gly Phe Val Ala Glu Val Glu His Leu Val Gln Gln Gly Leu Ile

215 220 225gct gac tcc acc gcg gga cga gca atc ggc tac tcc caa gta ctg gca 835Ala Asp Ser Thr Ala Gly Arg Ala Ile Gly Tyr Ser Gln Val Leu Ala230 235 240 245gcc atg gca ggg gag atg acc tgg gaa gac gcc ttc gaa cgc acg gtc 883Ala Met Ala Gly Glu Met Thr Trp Glu Asp Ala Phe Glu Arg Thr Val

250 255 260acc gga acc aga cgc tat gtc agg cgc caa cgc agc tgg ttc aac aga 931Thr Gly Thr Arg Arg Tyr Val Arg Arg Gln Arg Ser Trp Phe Asn Arg

265 270 275gac cac cgc gtg tcc tgg gtc gac gcc tct ggc gat ccc acc gca caa 979Asp His Arg Val Ser Trp Val Asp Ala Ser Gly Asp Pro Thr Ala Gln

280 285 290gcc ttg gag att ttg ggt cta caa tagcgagggt gaatttgacc atc 1026Ala Leu Glu Ile Leu Gly Leu Gln

295300<210>278<211>301<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>278Val Val Thr Pro Ile Ala Val Val Gly Pro Thr Ala Ser Gly Lys Ser 151015 Ala Leu Gly Ile Ala Leu Ala His Lys Leu Asp Gly Glu Val Val Asn

20 25 30Val Asp Ser Met Gln Leu Tyr Lys Gly Met Asp Ile Gly Thr Ala Lys

35 40 45Leu Thr Val Glu Glu Arg Glu Gly Ile Ala His His Gln Leu Asp Val

50 55 60Trp Asp Val Thr Glu Thr Ala Ser Val Ala Arg Phe Gln Ser Asp Ala 65 70 75 80Val Ala Asp Val Glu Asp Ile Met Ser Arg Gly Lys Thr Pro Ile Leu

85 90 95Val Gly Gly Ser Met Leu Tyr Val Gln Ser Leu Val Asp Asp Trp Gln

100 105 110Phe Pro Pro Thr Asp Ser Ala Val Arg Ala Arg Phe Glu Ala Arg Leu

115 120 125Ala Asp Ile Gly Val Glu Ala Leu His Ala Glu Leu Thr Gln Leu Asp

130 135 140Pro Glu Ala Ala Ala Val Ile Glu Ser Asn Asp Pro Arg Arg Thr Val145 150 155 160Arg Ala Leu Glu Val Ile Glu Leu Thr Gly Gln Pro Phe Gln Ala Ser

165 170 175Gln Pro Pro Lys Asp Ala Pro Pro Arg Trp Gly Thr Arg Ile Ile Gly

180 185 190Leu Lys Thr Thr Pro Glu Trp Leu Asn Pro Arg Ile Glu Gln Arg Thr

195 200 205Ala Arg Met Phe Glu Gln Gly Phe Val Ala Glu Val Glu His Leu Val

210 215 220Gln Gln Gly Leu Ile Ala Asp Ser Thr Ala Gly Arg Ala Ile Gly Tyr225 230 235 240Ser Gln Val Leu Ala Ala Met Ala Gly Glu Met Thr Trp Glu Asp Ala

245 250 255Phe Glu Arg Thr Val Thr Gly Thr Arg Arg Tyr Val Arg Arg Gln Arg

260 265 270Ser Trp Phe Asn Arg Asp His Arg Val Ser Trp Val Asp Ala Ser Gly

275 280 285Asp Pro Thr Ala Gln Ala Leu Glu Ile Leu Gly Leu Gln

290295300<210>279<211>954<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (931)<223>RXC01971<400>279aggtcttgtt tatttcggct actgattcag tagctgcgct ccgataggat tcttagtttt 60cagttcagta tctttgagcc acggctagaa tgtgaatcct atg tct aag aag aag 115

Met Ser Lys Lys Lys

1 5cct cgc ccc att ccg gtt cct gcc caa ttt atc cct ggt ctc att gat 163Pro Arg Pro Ile Pro Val Pro Ala Gln Phe Ile Pro Gly Leu Ile Asp

10 15 20gcg cat aca cat ttg gca tcg tgt gga gga gat ctt gca ggg ttg gtg 211Ala His Thr His Leu Ala Ser Cys Gly Gly Asp Leu Ala Gly Leu Val

25 30 35gaa agg gcc aag gag gcg ggc gtc gaa aag ctt tgt acc gtc ggt gat 259Glu Arg Ala Lys Glu Ala Gly Val Glu Lys Leu Cys Thr Val Gly Asp

40 45 50ggt ttg gct gag gcc gag ctt gcg ctg gag gcc gcg caa cag ttt ggc 307Gly Leu Ala Glu Ala Glu Leu Ala Leu Glu Ala Ala Gln Gln Phe Gly

55 60 65aat gtg ttt gct gcg tgt gcg att cat ccg acg aag gct gat cag ttg 355Asn Val Phe Ala Ala Cys Ala Ile His Pro Thr Lys Ala Asp Gln Leu 70 75 80 85gat ggg gct gcg cgt gcg cgg ctg acg cag atg gcg gcg gat ccg aat 403Asp Gly Ala Ala Arg Ala Arg Leu Thr Gln Met Ala Ala Asp Pro Asn

90 95 100tgt gtg gcc att ggt gag act ggt ttg gat tcg tat tgg atc aag cac 451Cys Val Ala Ile Gly Glu Thr Gly Leu Asp Ser Tyr Trp Ile Lys His

105 110 115gat cca gag gac acg gcg gcg ttg gat gtg caa gag gag gcg ctg cgc 499Asp Pro Glu Asp Thr Ala Ala Leu Asp Val Gln Glu Glu Ala Leu Arg

120 125 130tgg cat att gat ttg gca att agt gcg gat aag ccg ttg atg att cac 547Trp His Ile Asp Leu Ala Ile Ser Ala Asp Lys Pro Leu Met Ile His

135 140 145aat cgt gag gcg gat gct gat ttg atg cga gtg ttg gcg gat gct cca 595Asn Arg Glu Ala Asp Ala Asp Leu Met Arg Val Leu Ala Asp Ala Pro150 155 160 165cct cca aaa gat acg att ctg cat tgt ttt tct tcg ccg ttg gac gtg 643Pro Pro Lys Asp Thr Ile Leu His Cys Phe Ser Ser Pro Leu Asp Val

170 175 180gcg aag gaa gcg ttggat cgt gga tat gtg ttg agt ttt gcg ggc aat 691Ala Lys Glu Ala Leu Asp Arg Gly Tyr Val Leu Ser Phe Ala Gly Asn

185 190 195gtg acg ttt aag cgt aat gag gag ttg cgg gag gct gct cgt att gcg 739Val Thr Phe Lys Arg Asn Glu Glu Leu Arg Glu Ala Ala Arg Ile Ala

200 205 210ccg att tcc cag att ttg att gaa acc gat gcg ccg tat atg acg ccg 787Pro Ile Ser Gln Ile Leu Ile Glu Thr Asp Ala Pro Tyr Met Thr Pro

215 220 225gag ccg ttt cgg ggg agt agg aat gag ccg tcg ttg att ggt cat acg 835Glu Pro Phe Arg Gly Ser Arg Asn Glu Pro Ser Leu Ile Gly His Thr230 235 240 245gcg cta tgc att gcg gag gtt cgg ggg atg gct gtg gag gat gtt gcg 883Ala Leu Cys Ile Ala Glu Val Arg Gly Met Ala Val Glu Asp Val Ala

250 255 260gcg gct ttg aat gag aat ttt gat cgc gtt tat ggg gtc aca aat cta 931Ala Ala Leu Asn Glu Asn Phe Asp Arg Val Tyr Gly Val Thr Asn Leu

265270275 taacgtgagg tagctcacag tca 954<210>280<211>277<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>280Met Ser Lys Lys Lys Pro Arg Pro Ile Pro Val Pro Ala Gln Phe Ile 151015 Pro Gly Leu Ile Asp Ala His Thr His Leu Ala Ser Cys Gly Gly Asp

20 25 30Leu Ala Gly Leu Val Glu Arg Ala Lys Glu Ala Gly Val Glu Lys Leu

35 40 45Cys Thr Val Gly Asp Gly Leu Ala Glu Ala Glu Leu Ala Leu Glu Ala

50 55 60Ala Gln Gln Phe Gly Asn Val Phe Ala Ala Cys Ala Ile His Pro Thr 65 70 75 80LysAla Asp Gln Leu Asp Gly Ala Ala Arg Ala Arg Leu Thr Gln Met

85 90 95Ala Ala Asp Pro Asn Cys Val Ala Ile Gly Glu Thr Gly Leu Asp Ser

100 105 110Tyr Trp Ile Lys His Asp Pro Glu Asp Thr Ala Ala Leu Asp Val Gln

115 120 125Glu Glu Ala Leu Arg Trp His Ile Asp Leu Ala Ile Ser Ala Asp Lys

130 135 140Pro Leu Met Ile His Asn Arg Glu Ala Asp Ala Asp Leu Met Arg Val145 150 155 160Leu Ala Asp Ala Pro Pro Pro Lys Asp Thr Ile Leu His Cys Phe Ser

165 170 175Ser Pro Leu Asp Val Ala Lys Glu Ala Leu Asp Arg Gly Tyr Val Leu

180 185 190Ser Phe Ala Gly Asn Val Thr Phe Lys Arg Asn Glu Glu Leu Arg Glu

195 200 205Ala Ala Arg Ile Ala Pro Ile Ser Gln Ile Leu Ile Glu Thr Asp Ala

210 215 220Pro Tyr Met Thr Pro Glu Pro Phe Arg Gly Ser Arg Asn Glu Pro Ser225 230 235 240Leu Ile Gly His Thr Ala Leu Cys Ile Ala Glu Val Arg Gly Met Ala

245 250 255Val Glu Asp Val Ala Ala Ala Leu Asn Glu Asn Phe Asp Arg Val Tyr

260 265 270Gly Val Thr Asn Leu

275<210>281<211>1650<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1627)<223>RXC02697<400>281tttggctcac ctcgatgatg tagacatccc cgatgaggtg cgcgcacagt tgcgggcact 60ggctatccgc tcaaccgaac gtcggatgta gtagacgcgt atg aca ctt ttt caa 115

Met Thr Leu Phe Gln

1 5cgt tta acc aac cct gta gtg ctc ggc ggc cta gca ggt gtt ttg ctt 163Arg Leu Thr Asn Pro Val Val Leu Gly Gly Leu Ala Gly Val Leu Leu

10 15 20ctg ctc ggc tct ttc ggt ggc ggt gcc att cgg tac cgt ggc gga gtg 211Leu Leu Gly Ser Phe Gly Gly Gly Ala Ile Arg Tyr Arg Gly Gly Val

25 30 35ctc gat gcg ttg ggg ctt aac ttc ctt gct ttt ggc cac gcg cag ggt 259Leu Asp Ala Leu Gly Leu Asn Phe Leu Ala Phe Gly His Ala Gln Gly

40 45 50att tcc aat acc gtg ttg tgg gtt ggg cag ctg ctg ctg att ggc gcg 307Ile Ser Asn Thr Val Leu Trp Val Gly Gln Leu Leu Leu Ile Gly Ala

55 60 65tgg gtt cac ctt gga cgt cgg ttg ttc aag aaa aaa gtc gct gat gac 355Trp Val His Leu Gly Arg Arg Leu Phe Lys Lys Lys Val Ala Asp Asp 70 75 80 85acc gca gac gct gct gac tta ggt ctt gta aag cgc acg ttg tat gcc 403Thr Ala Asp Ala Ala Asp Leu Gly Leu Val Lys Arg Thr Leu Tyr Ala

90 95 100atg gtg gtg ccc ctc att ttt gcg gca cca atg atg tcg cgt gat gtt 451Met Val Val Pro Leu Ile Phe Ala Ala Pro Met Met Ser Arg Asp Val

105 110 115tat tcc tat ctc atg cag ggc gcg atg ctg cgt gat ggc ttc gat ccc 499Tyr Ser Tyr Leu Met Gln Gly Ala Met Leu Arg Asp Gly Phe Asp Pro

120 125130tac act gag ggc gct gcg gta aac cct ggc ccc atg ttg ctt gag gtc 547Tyr Thr Glu Gly Ala Ala Val Asn Pro Gly Pro Met Leu Leu Glu Val

135 140 145tct cat gat tgg cgc aac acc acg acg ccg tat ggt cca cta cac ctg 595Ser His Asp Trp Arg Asn Thr Thr Thr Pro Tyr Gly Pro Leu His Leu150 155 160 165tgg att gga gac atg atc acc acg gtt gtg ggc gat aat gtc acc ttg 643Trp Ile Gly Asp Met Ile Thr Thr Val Val Gly Asp Asn Val Thr Leu

170 175 180ggc gtc gtc gct tac aag atc ttg tcg atc att ggc ctt gct gtg aca 691Gly Val Val Ala Tyr Lys Ile Leu Ser Ile Ile Gly Leu Ala Val Thr

185 190 195ggc tgg agc att gtc cgc att gca caa cat ttt gga gcc aac cca gca 739Gly Trp Ser Ile Val Arg Ile Ala Gln His Phe Gly Ala Asn Pro Ala

200 205 210att gca ttg tgg att ggt gtg gcc aat cct gtg atg atc atc cac atg 787Ile Ala Leu Trp Ile Gly Val Ala Asn Pro Val Met Ile Ile His Met

215 220 225atc ggc ggc atg cac aat gaa tcc ctc atg gtg gga ttg gtc agc gtc 835Ile Gly Gly Met His Asn Glu Ser Leu Met Val Gly Leu Val Ser Val230 235 240 245ggc ttg ttg cta gca ctg aag aag cgt ttc gtg gca ggt gtg gca ctc 883Gly Leu Leu Leu Ala Leu Lys Lys Arg Phe Val Ala Gly Val Ala Leu

250 255 260att gca gtg gct gtg tcg ctg aaa gct aca gcg gcg att gca ctt cct 931Ile Ala Val Ala Val Ser Leu Lys Ala Thr Ala Ala Ile Ala Leu Pro

265 270 275ttt gtg gtg tgg atc ggc atg cat cat ttc gca gga ttc tta gcc acc 979Phe Val Val Trp Ile Gly Met His His Phe Ala Gly Phe Leu Ala Thr

280 285 290aaa aag ggc aaa gac tcc cct acc ctt aag caa cag gtc ccc gcg ttc 1027Lys Lys Gly Lys Asp Ser Pro Thr Leu Lys Gln Gln Val Pro Ala Phe

295 300 305ttt gcc act gga gct gca ggt gtt gct gtc act ggt gtt gtt gtc agt 1075Phe Ala Thr Gly Ala Ala Gly Val Ala Val Thr Gly Val Val Val Ser310 315 320 325gcg atc act tgg gcg tct ggc gct tcg tgg ggc tgg atc agt gag atc 1123Ala Ile Thr Trp Ala Ser Gly Ala Ser Trp Gly Trp Ile Ser Glu Ile

330 335 340agt ggc aac agc aag gta atc aac ccg ctg gct ttc cct tct ttg gtg 1171Ser Gly Asn Ser Lys Val Ile Asn Pro Leu Ala Phe Pro Ser Leu Val

345 350 355gcc agt gtg atc acc atg gtg gct gaa gtg ttc gtt gac gat ttc gac 1219Ala Ser Val Ile Thr Met Val Ala Glu Val Phe Val Asp Asp Phe Asp

360 365 370tac aac gca gtg gtt aat gtt gtg cgc tca atc tcc atg ctg atc atg 1267Tyr Asn Ala Val Val Asn Val Val Arg Ser Ile Ser Met Leu Ile Met

375 380 385ctt ggc ggg ttg gtc gta tgt tgg tgg ctg ttc cgc cag aac gaa cgc 1315Leu Gly Gly Leu Val Val Cys Trp Trp Leu Phe Arg Gln Asn Glu Arg390 395 400 405agg gcg gtc act ggt aca gca gcg gct tat gcc gtg gct ttt gtg ttc 1363Arg Ala Val Thr Gly Thr Ala Ala Ala Tyr Ala Val Ala Phe Val Phe

410 415 420aat tct gtg acc ttg ccg tgg tac tac gcc agc ttg atc tct ttg ctc 1411Asn Ser Val Thr Leu Pro Trp Tyr Tyr Ala Ser Leu Ile Ser Leu Leu

425 430 435ggc aca ttt aaa cca ccg atg tgg ttg att cgc ttc gca gcg ggt gct 1459Gly Thr Phe Lys Pro Pro Met Trp Leu Ile Arg Phe Ala Ala Gly Ala

440 445 450tcg gtg ttt atc gcg ctg atg ttt acc gga agt gga aac cac cag ctg 1507Ser Val Phe Ile Ala Leu Met Phe Thr Gly Ser Gly Asn His Gln Leu

455 460 465tac aac atc gtt acg gtg atc atc gca gca att atc gcg tgg ctt gcc 1555Tyr Asn Ile Val Thr Val Ile Ile Ala Ala Ile Ile Ala Trp Leu Ala470 475 480 485acc gtg gtg atc ttt gat gac act gac cct gca aca acg gcc acg gag 1603Thr Val Val Ile Phe Asp Asp Thr Asp Pro Ala Thr Thr Ala Thr Glu

490 495 500aaa ccc tcc ccg cat acc gtt tcc tagttgcata aggtaaaccg cca 1650Lys Pro Ser Pro His Thr Val Ser

505<210>282<211>509<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>282Met Thr Leu Phe Gln Arg Leu Thr Asn Pro Val Val Leu Gly Gly Leu 151015 Ala Gly Val Leu Leu Leu Leu Gly Ser Phe Gly Gly Gly Ala Ile Arg

20 25 30Tyr Arg Gly Gly Val Leu Asp Ala Leu Gly Leu Asn Phe Leu Ala Phe

35 40 45Gly His Ala Gln Gly Ile Ser Asn Thr Val Leu Trp Val Gly Gln Leu

50 55 60Leu Leu Ile Gly Ala Trp Val His Leu Gly Arg Arg Leu Phe Lys Lys 65 70 75 80Lys Val Ala Asp Asp Thr Ala Asp Ala Ala Asp Leu Gly Leu Val Lys

85 90 95Arg Thr Leu Tyr Ala Met Val Val Pro Leu Ile Phe Ala Ala Pro Met

100 105 110Met Ser Arg Asp Val Tyr Ser Tyr Leu Met Gln Gly Ala Met Leu Arg

115 120 125Asp Gly Phe Asp Pro Tyr Thr Glu Gly Ala Ala Val Asn Pro Gly Pro

130 135 140Met Leu Leu Glu Val Ser His Asp Trp Arg Asn Thr Thr Thr Pro Tyr145 150 155 160Gly Pro Leu His Leu Trp Ile Gly Asp Met Ile Thr Thr Val Val Gly

165 170 175Asp Asn Val Thr Leu Gly Val Val Ala Tyr Lys Ile Leu Ser Ile Ile

180 185 190Gly Leu Ala Val Thr Gly Trp Ser Ile Val Arg Ile Ala Gln His Phe

195 200 205Gly Ala Asn Pro Ala Ile Ala Leu Trp Ile Gly Val Ala Asn Pro Val

210 215 220Met Ile Ile His Met Ile Gly Gly Met His Asn Glu Ser Leu Met Val225 230 235 240Gly Leu Val Ser Val Gly Leu Leu Leu Ala Leu Lys Lys Arg Phe Val

245 250 255Ala Gly Val Ala Leu Ile Ala Val Ala Val Ser Leu Lys Ala Thr Ala

260 265 270Ala Ile Ala Leu Pro Phe Val Val Trp Ile Gly Met His His Phe Ala

275 280 285Gly Phe Leu Ala Thr Lys Lys Gly Lys Asp Ser Pro Thr Leu Lys Gln

290 295 300Gln Val Pro Ala Phe Phe Ala Thr Gly Ala Ala Gly Val Ala Val Thr305 310 315 320Gly Val Val Val Ser Ala Ile Thr Trp Ala Ser Gly Ala Ser Trp Gly

325 330 335Trp Ile Ser Glu Ile SerGly Asn Ser Lys Val Ile Asn Pro Leu Ala

340 345 350Phe Pro Ser Leu Val Ala Ser Val Ile Thr Met Val Ala Glu Val Phe

355 360 365Val Asp Asp Phe Asp Tyr Asn Ala Val Val Asn Val Val Arg Ser Ile

370 375 380Ser Met Leu Ile Met Leu Gly Gly Leu Val Val Cys Trp Trp Leu Phe385 390 395 400Arg Gln Asn Glu Arg Arg Ala Val Thr Gly Thr Ala Ala Ala Tyr Ala

405 410 415Val Ala Phe Val Phe Asn Ser Val Thr Leu Pro Trp Tyr Tyr Ala Ser

420 425 430Leu Ile Ser Leu Leu Gly Thr Phe Lys Pro Pro Met Trp Leu Ile Arg

435 440 445Phe Ala Ala Gly Ala Ser Val Phe Ile Ala Leu Met Phe Thr Gly Ser

450 455 460Gly Asn His Gln Leu Tyr Asn Ile Val Thr Val Ile Ile Ala Ala Ile465 470 475 480Ile Ala Trp Leu Ala Thr Val Val Ile Phe Asp Asp Thr Asp Pro Ala

485 490 495Thr Thr Ala Thr Glu Lys Pro Ser Pro His Thr Val Ser

500505<210>283<211>1298<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (1275)<223>RXN01946<400>283atc cgc aag tac tcc agg ctc gag gaa caa ttc cag tcg ctc ggc ggc 48Ile Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly Gly 151015 tac gaa gct gac gcc gaa gca gcc cag atc tgc gac aac ctc ggc ctc 96Tyr Glu Ala Asp Ala Glu Ala Ala Gln Ile Cys Asp Asn Leu Gly Leu

20 25 30gag gca cgc atc ctc gac cag cag ctt aaa acc ctg tcc ggc ggc cag 144Glu Ala Arg Ile Leu Asp Gln Gln Leu Lys Thr Leu Ser Gly Gly Gln

35 40 45cgc cgc cgc gtc gag ttg gcg cag atc ctc ttc gcc gcc acc aac ggc 192Arg Arg Arg Val Glu Leu Ala Gln Ile Leu Phe Ala Ala Thr Asn Gly

50 55 60tcc ggc aaa tca aaa acc aca ttg ctt ctc gac gag ccc acc aac cac 240Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glu Pro Thr Asn His 65 70 75 80ttg gac gca gac tcg atc acc tgg ctc cgt gac ttc ctg gcg aag cac 288Leu Asp Ala Asp Ser Ile Thr Trp Leu Arg Asp Phe Leu Ala Lys His

85 90 95gaa ggt gga ctg atc atg att tcg cac gac gtc gaa ctg ctt ggc gcc 336Glu Gly Gly Leu Ile Met Ile Ser His Asp Val Glu Leu Leu Gly Ala

100 105 110gta tgt aac aag att tgg tac ctc gac gca gta cgc agc gaa gcc gat 384Val Cys Asn Lys Ile Trp Tyr Leu Asp Ala Val Arg Ser Glu Ala Asp

115 120 125gtc tac aac atg ggc ttt agc aaa tac gtc gat gca cgt gca ctc gat 432Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Ala Arg Ala Leu Asp

130 135 140gaa gca cgc cga cgc cgt gag cgc gca aac gcc gaa aag aag gcc gga 480Glu Ala Arg Arg Arg Arg Glu Arg Ala Asn Ala Glu Lys Lys Ala Gly145 150 155 160gcc ctc aag gac cag gct gca cgc ctc ggc gcg aaa gca acc aag gct 528Ala Leu Lys Asp Gln Ala Ala Arg Leu Gly Ala Lys Ala Thr Lys Ala

165 170 175gcc gca gct aag cag atg atc gcc cgt gcg gaa cga atg atc gac aac 576Ala Ala Ala Lys Gln Met Ile Ala Arg Ala Glu Arg Met Ile Asp Asn

180 185 190ctc gac gaa atc cgc gta gct gac cgc gcc gcc aac atc gtt ttc cca 624Leu Asp Glu Ile Arg Val Ala Asp Arg Ala Ala Asn Ile Val Phe Pro

195 200 205gaa cca gca ccc tgt gga aaa acc cca ctc aac gcc aag ggc ctg acc 672Glu Pro Ala Pro Cys Gly Lys Thr Pro Leu Asn Ala Lys Gly Leu Thr

210 215 220aag atg tac ggc tcc ctc gaa gtc ttc gcc ggc gtc gac cta gcc atc 720Lys Met Tyr Gly Ser Leu Glu Val Phe Ala Gly Val Asp Leu Ala Ile225 230 235 240gac aaa ggc tcc cgc gta gtc gtc ctc gga ttc aac ggt gca ggt aaa 768Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Ala Gly Lys

245 250 255acc acc ctg ctc aaa ctc ctc gcc ggt gtg gaa cgc acc gac ggc gaa 816Thr Thr Leu Leu Lys Leu Leu Ala Gly Val Glu Arg Thr Asp Gly Glu

260 265 270ggc ggc atc gtc acc gga tac ggc ctc aaa atc ggc tac ttc gcc cag 864Gly Gly Ile Val Thr Gly Tyr Gly Leu Lys Ile Gly Tyr Phe Ala Gln

275 280 285gaa cac gac acc atc gac ccc gac aaa tcc gtc tgg caa aac acc atc 912Glu His Asp Thr Ile Asp Pro Asp Lys Ser Val Trp Gln Asn Thr Ile

290 295 300gaa gcc tgc gcc gac gcc gac caa caa agc ctc cgc agc ctc ctc gga 960Glu Ala Cys Ala Asp Ala Asp Gln Gln Ser Leu Arg Ser Leu Leu Gly305 310 315 320tcc ttc atg ttc tcc ggc gaa caa ctc gac caa cca gca gga aca ctc 1008Ser Phe Met Phe Ser Gly Glu Gln Leu Asp Gln Pro Ala Gly Thr Leu

325330 335tcc ggc ggt gaa aaa acc cgc ctc gca ctg gcc acc ctc gtg tcc tcc 1056Ser Gly Gly Glu Lys Thr Arg Leu Ala Leu Ala Thr Leu Val Ser Ser

340 345 350cgc gca aac gtc ctg ctt ctc gac gag ccc acc aac aac ctt gac ccg 1104Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Pro

355 360 365atc tcc cgc gaa cag gtc ctc gac gca ctg cgc acc tac acc ggc gca 1152Ile Ser Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Ala

370 375 380gtc gtc ctg gtt acc cac gac ccg ggt gca gtc aag gcc ctt gag cca 1200Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu Pro385 390 395 400gaa cgc gtc atc gtg ctt cct gat ggc acc gag gat ctt tgg aat gat 1248Glu Arg Val Ile Val Leu Pro Asp Gly Thr GIu Asp Leu Trp Asn Asp

405 410 415cag tac atg gaa atc gtg gaa ttg gcg taggttctaa ggctgtttat 1295Gln Tyr Met Glu Ile Val Glu Leu Ala

420425 gct1298<210>284<211>425<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>284Ile Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly Gly 151015 Tyr Glu Ala Asp Ala Glu Ala Ala Gln Ile Cys Asp Asn Leu Gly Leu

20 25 30Glu Ala Arg Ile Leu Asp Gln Gln Leu Lys Thr Leu Ser Gly Gly Gln

35 40 45Arg Arg Arg Val Glu Leu Ala Gln Ile Leu Phe Ala Ala Thr Asn Gly

50 55 60Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glu Pro Thr Asn His 65 70 7580Leu Asp Ala Asp Ser Ile Thr Trp Leu Arg Asp Phe Leu Ala Lys His

85 90 95Glu Gly Gly Leu Ile Met Ile Ser His Asp Val Glu Leu Leu Gly Ala

100 105 110Val Cys Asn Lys Ile Trp Tyr Leu Asp Ala Val Arg Ser Glu Ala Asp

115 120 125Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Ala Arg Ala Leu Asp

130 135 140Glu Ala Arg Arg Arg Arg Glu Arg Ala Asn Ala Glu Lys Lys Ala Gly145 150 155 160Ala Leu Lys Asp Gln Ala Ala Arg Leu Gly Ala Lys Ala Thr Lys Ala

165 170 175Ala Ala Ala Lys Gln Met Ile Ala Arg Ala Glu Arg Met Ile Asp Asn

180 185 190Leu Asp Glu Ile Arg Val Ala Asp Arg Ala Ala Asn Ile Val Phe Pro

195 200 205Glu Pro Ala Pro Cys Gly Lys Thr Pro Leu Asn Ala Lys Gly Leu Thr

210 215 220Lys Met Tyr Gly Ser Leu Glu Val Phe Ala Gly Val Asp Leu Ala Ile225 230 235 240Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Ala Gly Lys

245 250 255Thr Thr Leu Leu Lys Leu Leu Ala Gly Val Glu Arg Thr Asp Gly Glu

260 265 270Gly Gly Ile Val Thr Gly Tyr Gly Leu Lys Ile Gly Tyr Phe Ala Gln

275 280 285Glu His Asp Thr Ile Asp Pro Asp Lys Ser Val Trp Gln Asn Thr Ile

290 295 300Glu Ala Cys Ala Asp Ala Asp Gln Gln Ser Leu Arg Ser Leu Leu Gly305 310 315 320Ser Phe Met Phe Ser Gly Glu Gln Leu Asp Gln Pro Ala Gly Thr Leu

325 330 335Ser Gly Gly Glu Lys Thr Arg Leu Ala Leu Ala Thr Leu Val Ser Ser

340 345 350Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Pro

355 360 365Ile Ser Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Ala

370 375 380Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu Pro

390 395 400Glu Arg Val Ile Val Leu Pro Asp Gly Thr Glu Asp Leu Trp Asn Asp

405 410 415Gln Tyr Met Glu Ile Val Glu Leu Ala

420425<210>285<211>1298<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (1275)<223>FRXA01946<400>285atc cgc aag tac tcc agg ctc gag gaa caa ttc cag tcg ctc ggc ggc 48Ile Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly Gly 151015 tac gaa gct gac gcc gaa gca gcc cag atc tgc gac aac ctc ggc ctc 96Tyr Glu Ala Asp Ala Glu Ala Ala Gln Ile Cys Asp Asn Leu Gly Leu

20 25 30gag gca cgc atc ctc gac cag cag ctt aaa acc ctg tcc ggc ggc cag 144Glu Ala Arg Ile Leu Asp Gln Gln Leu Lys Thr Leu Ser Gly Gly Gln

35 40 45cgc cgc cgc gtc gag ttg gcg cag atc ctc ttc gcc gcc acc aac ggc 192Arg Arg Arg Val Glu Leu Ala Gln Ile Leu Phe Ala Ala Thr Asn Gly

50 55 60tcc ggc aaa tca aaa acc aca ttg ctt ctc gac gag ccc acc aac cac 240Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glu Pro Thr Asn His 65 70 75 80ttg gac gca gac tcg atc acc tgg ctc cgt gac ttc ctg gcg aag cac 288Leu Asp Ala Asp Ser Ile Thr Trp Leu Arg Asp Phe Leu Ala Lys His

85 90 95gaa ggt gga ctg atc atg att tcg cac gac gtc gaa ctg ctt ggc gcc 336Glu Gly Gly Leu Ile Met Ile Ser His Asp Val Glu Leu Leu Gly Ala

100 105 110gta tgt aac aag att tgg tac ctc gac gca gta cgc agc gaa gcc gat 384Val Cys Asn Lys Ile Trp Tyr Leu Asp Ala Val Arg Ser Glu Ala Asp

115 120 125gtc tac aac atg ggc ttt agc aaa tac gtc gat gca cgt gca crc gat 432Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Ala Arg Ala Leu Asp

130 135 140gaa gca cgc cga cgc cgt gag cgc gca aac gcc gaa aag aag gcc gga 480Glu Ala Arg Arg Arg Arg Glu Arg Ala Asn Ala Glu Lys Lys Ala Gly145 150 155 160gcc ctc aag gac cag gct gca cgc ctc ggc gcg aaa gca acc aag gct 528Ala Leu Lys Asp Gln Ala Ala Arg Leu Gly Ala Lys Ala Thr Lys Ala

165 170 175gcc gca gct aag cag atg atc gcc cgt gcg gaa cga atg atc gac aac 576Ala Ala Ala Lys Gln Met Ile Ala Arg Ala Glu Arg Met Ile Asp Asn

180 185 190ctc gac gaa atc cgc gta gct gac cgc gcc gcc aac atc gtt ttc cca 624Leu Asp Glu Ile Arg Val Ala Asp Arg Ala Ala Asn Ile Val Phe Pro

195 200 205gaa cca gca ccc tgt gga aaa acc cca ctc aac gcc aag ggc ctg acc 672Glu Pro Ala Pro Cys Gly Lys Thr Pro Leu Asn Ala Lys Gly Leu Thr

210 215 220aag atg tac ggc tcc ctc gaa gtc ttc gcc ggc gtc gac cta gcc atc 720Lys Met Tyr Gly Ser Leu Glu Val Phe Ala Gly Val Asp Leu Ala Ile225 230 235 240gac aaa ggc tcc cgc gta gtc gtc ctc gga ttc aac ggt gca ggt aaa 768Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Ala Gly Lys

245 250 255acc acc ctg ctc aaa ctc ctc gcc ggt gtg gaa cgc acc gac ggc gaa 816Thr Thr Leu Leu Lys Leu Leu Ala Gly Val Glu Arg Thr Asp Gly Glu

260 265 270ggc ggc atc gtc acc gga tac ggc ctc aaa atc ggc tac ttc gcc cag 864Gly Gly Ile Val Thr Gly Tyr Gly Leu Lys Ile Gly Tyr Phe Ala Gln

275 280 285gaa cac gac acc atc gac ccc gac aaa tcc gtc tgg caa aac acc atc 912Glu His Asp Thr Ile Asp Pro Asp Lys Ser Val Trp Gln Asn Thr Ile

290 295 300gaa gcc tgc gcc gac gcc gac caa caa agc ctc cgc agc ctc ctc gga 960Glu Ala Cys Ala Asp Ala Asp Gln Gln Ser Leu Arg Ser Leu Leu Gly305 310 315 320tcc ttc atg ttc tcc ggc gaa caa ctc gac caa cca gca gga aca ctc 1008Ser Phe Met Phe Ser Gly Glu Gln Leu Asp Gln Pro Ala Gly Thr Leu

325 330 335tcc ggc ggt gaa aaa acc cgc ctc gca ctg gcc acc ctc gtg tcc tcc 1056Ser Gly Gly Glu Lys Thr Arg Leu Ala Leu Ala Thr Leu Val Ser Ser

340 345 350cgc gca aac gtc ctg ctt ctc gac gag ccc acc aac aac ctt gac ccg 1104Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Pro

355 360 365atc tcc cgc gaa cag gtc ctc gac gca ctg cgc acc tac acc ggc gca 1152Ile Ser Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Ala

370 375 380gtc gtc ctg gtt acc cac gac ccg ggt gca gtc aag gcc ctt gag cca 1200Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu Pro385 390 395 400gaa cgc gtc atc gtg ctt cct gat ggc acc gag gat ctt tgg aat gat 1248Glu Arg Val Ile Val Leu Pro Asp Gly Thr Glu Asp Leu Trp Asn Asp

405 410 415cag tac atg gaa atc gtg gaa ttg gcg taggttctaa ggctgtttat 1295Gln Tyr Met Glu Ile Val Glu Leu Ala

420425 gct1298<210>286<211>425<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>286Ile Arg Lys Tyr Ser Arg Leu Glu Glu Gln Phe Gln Ser Leu Gly Gly 151015 Tyr Glu Ala Asp Ala Glu Ala Ala Gln Ile Cys Asp Asn Leu Gly Leu

20 25 30Glu Ala Arg Ile Leu Asp Gln Gln Leu Lys Thr Leu Ser Gly Gly Gln

35 40 45Arg Arg Arg Val Glu Leu Ala Gln Ile Leu Phe Ala Ala Thr Asn Gly

50 55 60Ser Gly Lys Ser Lys Thr Thr Leu Leu Leu Asp Glu Pro Thr Asn His 65 70 75 80Leu Asp Ala Asp Ser Ile Thr Trp Leu Arg Asp Phe Leu Ala Lys His

85 90 95Glu Gly Gly Leu Ile Met Ile Ser His Asp Val Glu Leu Leu Gly Ala

100 105 110Val Cys Asn Lys Ile Trp Tyr Leu Asp Ala Val Arg Ser Glu Ala Asp

115 120 125Val Tyr Asn Met Gly Phe Ser Lys Tyr Val Asp Ala Arg Ala Leu Asp

130 135 l40Glu Ala Arg Arg Arg Arg Glu Arg Ala Asn Ala Glu Lys Lys Ala Gly145 150 155 160Ala Leu Lys Asp Gln Ala Ala Arg Leu Gly Ala Lys Ala Thr Lys Ala

165 170 175Ala Ala Ala Lys Gln Met Ile Ala Arg Ala Glu Arg Met Ile Asp Asn

180 185 190Leu Asp Glu Ile Arg Val Ala Asp Arg Ala Ala Asn Ile Val Phe Pro

195 200 205Glu Pro Ala Pro Cys Gly Lys Thr Pro Leu Asn Ala Lys Gly Leu Thr

210 215 220Lys Met Tyr Gly Ser Leu Glu Val Phe Ala Gly Val Asp Leu Ala Ile225 230 235 240Asp Lys Gly Ser Arg Val Val Val Leu Gly Phe Asn Gly Ala Gly Lys

245 250 255Thr Thr Leu Leu Lys Leu Leu Ala Gly Val Glu Arg Thr Asp Gly Glu

260 265 270Gly Gly Ile Val Thr Gly Tyr Gly Leu Lys Ile Gly Tyr Phe Ala Gln

275 280 285Glu His Asp Thr Ile Asp Pro Asp Lys Ser Val Trp Gln Asn Thr Ile

290 295 300Glu Ala Cys Ala Asp Ala Asp Gln Gln Ser Leu Arg Ser Leu Leu Gly305 310 315 320Ser Phe Met Phe Ser Gly Glu Gln Leu Asp Gln Pro Ala Gly Thr Leu

325 330 335Ser Gly Gly Glu Lys Thr Arg Leu Ala Leu Ala Thr Leu Val Ser Ser

340 345 350Arg Ala Asn Val Leu Leu Leu Asp Glu Pro Thr Asn Asn Leu Asp Pro

355 360 365Ile Ser Arg Glu Gln Val Leu Asp Ala Leu Arg Thr Tyr Thr Gly Ala

370 375 380Val Val Leu Val Thr His Asp Pro Gly Ala Val Lys Ala Leu Glu Pro385 390 395 400Glu Arg Val Ile Val Leu Pro Asp Gly Thr Glu Asp Leu Trp Asn Asp

405 410 415Gln Tyr Met Glu Ile Val Glu Leu Ala

420425<210>287<211>1812<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1789)<223>RXN00164<400>287ctgctttgcg ggaggttatg aaatgagtgg ggagacgtcg aaaagcatgc gctttccgtt 60ggccagcctg ccgcaagtgc ggcgcgaggt ggcccggcag gtg ggt cgt att ccg 115

Val Gly Arg Ile Pro

1 5cgg gcg aag tgg tgg ttt tta ggc gcg ctg gtg ttg ctg agt gcg ggc 163Arg Ala Lys Trp Trp Phe Leu Gly Ala Leu Val Leu Leu Ser Ala Gly

10 15 20gct tat gcg tcg gtg ctg gtg ccg cag gtg ctg ggg cgg att gtg gat 211Ala Tyr Ala Ser Val Leu Val Pro Gln Val Leu Gly Arg Ile Val Asp

25 30 35ctg gtg tcc gat ggc gcg cag atg cgt gat ttt gtt gag ctc agt gtg 259Leu Val Ser Asp Gly Ala Gln Met Arg Asp Phe Val Glu Leu Ser Val

40 45 50att ctc att gcg gtg gca att gcc ggc gcg gtg ctc agt gcg tgc ggg 307Ile Leu Ile Ala Val Ala Ile Ala Gly Ala Val Leu Ser Ala Cys Gly

55 6065ttc tat gtg gtg tcg cgg att tct gag aag att atc gcc aat ttg agg 355Phe Tyr Val Val Ser Arg Ile Ser Glu Lys Ile Ile Ala Asn Leu Arg 70 75 80 85gaa gat atg gtg ggc acc gcg ctt ggg ttg ccc acg cac cag gtg gaa 403Glu Asp Met Val Gly Thr Ala Leu Gly Leu Pro Thr His Gln Val Glu

90 95 100gat gcg ggc tct ggc gat ttg gtg agc cgc tcc acc gat gat gtc tcc 451Asp Ala Gly Ser Gly Asp Leu Val Ser Arg Ser Thr Asp Asp Val Ser

105 110 115gag cta tcc gca gcg gtg aca gag acc gtc ccg att tta agt tcc tca 499Glu Leu Ser Ala Ala Val Thr Glu Thr Val Pro Ile Leu Ser Ser Ser

120 125 130ctg ttt acc att gcc gcg acg atc att gcg ctg ttt tct ttg gac tgg 547Leu Phe Thr Ile Ala Ala Thr Ile Ile Ala Leu Phe Ser Leu Asp Trp

135 140 145caa ttt gtg ctc att cct gtc gtg gtg gcg ccg gtg tac tac ttc gcg 595Gln Phe Val Leu Ile Pro Val Val Val Ala Pro Val Tyr Tyr Phe Ala150 155 160 165tcc aag cac tat ttg agc aag gcg ccg gat cgg tat gcg gca gaa cgc 643Ser Lys His Tyr Leu Ser Lys Ala Pro Asp Arg Tyr Ala Ala Glu Arg

170 175 180gcg gcg atg gcg gag cgt gcg cga aag gta ctt gag gct att cgc ggg 691Ala Ala Met Ala Glu Arg Ala Arg Lys Val Leu Glu Ala Ile Arg Gly

185 190 195cgt gca act gtg cgg gcg tat tcc atg gaa gat gcc atg cat aat cag 739Arg Ala Thr Val Arg Ala Tyr Ser Met Glu Asp Ala Met His Asn Gln

200 205 210att gat cag gcg tcg tgg tct gtg gtg gtc aag ggt att cgt gcg cgc 787Ile Asp Gln Ala SerTrp Ser Val Val Val Lys Gly Ile Arg Ala Arg

215 220 225acc acc atg ttg att ttg aac atg tgg atg ctg ttt gcg gaa ttc ctc 835Thr Thr Met Leu Ile Leu Asn Met Trp Met Leu Phe Ala Glu Phe Leu230 235 240 245atg ctc gcg gtc gcg ttg gtg atc ggc tac aag ctg gtc att gat aat 883Met Leu Ala Val Ala Leu Val Ile Gly Tyr Lys Leu Val Ile Asp Asn

250 255 260gcg ctg acg atc ggc gcg gtt acc ggt gcc gtg ctg atg att att cgt 931Ala Leu Thr Ile Gly Ala Val Thr Gly Ala Val Leu Met Ile Ile Arg

265 270 275ctg cgt ggc ccg atg aat atg ttc atg cgc gtg ctc gac acc att caa 979Leu Arg Gly Pro Met Asn Met Phe Met Arg Val Leu Asp Thr Ile Gln

280 285 290tcc ggc tat gcg tcg ctg gcg cgc atc gtg gga gtt gtt gcg gat ccg 1027Ser Gly Tyr Ala Ser Leu Ala Arg Ile Val Gly Val Val Ala Asp Pro

295 300 305ccg att cct gtg ccc gac agc ggt gtg aaa gca cct cag ggc aaa gtg 1075Pro Ile Pro Val Pro Asp Ser Gly Val Lys Ala Pro Gln Gly Lys Val310 315 320 325gaa ttg cgc aac gtc agc ttt agc tat ggc gat tcc tgg gcg gtg aaa 1123Glu Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp Ser Trp Ala Val Lys

330 335 340gac atc gac atc acg atc aat tcc ggc gaa act gtc gcg ctc gtg ggc 1171Asp Ile Asp Ile Thr Ile Asn Ser Gly Glu Thr Val Ala Leu Val Gly

345 350 355gca tct ggc gca ggt aag acg acg gtc gcc gcc ttg ctg gcg ggc ttg 1219Ala Ser Gly Ala Gly Lys Thr Thr Val Ala Ala Leu Leu Ala Gly Leu

360 365 370cgg gtg cca gat caa ggg caa gtg ctt gtc gac gac ttc ccc gtc tct 1267Arg Val Pro Asp Gln Gly Gln Val Leu Val Asp Asp Phe Pro Val Ser

375 380 385cac ctc tct gac cgc gag cgt atc gcc cgc ttg gcc atg gtc agc cag 1315His Leu Ser Asp Arg Glu Arg Ile Ala Arg Leu Ala Met Val Ser Gln390 395 400 405gag gtt cat gtt ttc tcc ggc acg ctg cgc cag gat ctc acc ttg gct 1363Glu Val His Val Phe Ser Gly Thr Leu Arg Gln Asp Leu Thr Leu Ala

410 415 420aaa cca gat gcc tcc gat gag gaa tta gcg cat gct ctt ggg caa gtt 1411Lys Pro Asp Ala Ser Asp Glu Glu Leu Ala His Ala Leu Gly Gln Val

425 430 435aat gcc ctt gac tgg ttg gag agt ctt cca gaa gga ctg gac acg gtc 1459Asn Ala Leu Asp Trp Leu Glu Ser Leu Pro Glu Gly Leu Asp Thr Val

440 445 450gtt ggt gcg cga gga atc cag cta gaa cca gtg gtg gct cag cag ttg 1507Val Gly Ala Arg Gly Ile Gln Leu Glu Pro Val Val Ala Gln Gln Leu

455 460 465gcg ttg gcc cgg gtg ttg ttg ctc aat ccg gcg atc gtc atc atg gat 1555Ala Leu Ala Arg Val Leu Leu Leu Asn Pro Ala Ile Val Ile Met Asp470 475 480 485gaa gcc acg gca gaa gca gga tcg gcg ggt gcc agc gca ctg gaa gag 1603Glu Ala Thr Ala Glu Ala Gly Ser Ala Gly Ala Ser Ala Leu Glu Glu

490 495 500gct gca gat gca gtg agc aag aac cgt tcc gca ttg gtg gtg gcg cac 1651Ala Ala Asp Ala Val Ser Lys Asn Arg Ser Ala Leu Val Val Ala His

505 510 515cgg ttg gat cag gca tcg cgg gct gat cag att ctg gtg atg gat aag 1699Arg Leu Asp Gln Ala Ser Arg AlaAsp Gln Ile Leu Val Met Asp Lys

520 525 530ggg gag gtt gtg gaa tcc ggt act cac cag gag tta ttg gat cac ggg 1747Gly Glu Val Val Glu Ser Gly Thr His Gln Glu Leu Leu Asp His Gly

535540545 ggt att tat cag cgt ctg tgg act gcg tgg agt gtc gga aga 1789Gly Ile Tyr Gln Arg Leu Trp Thr Ala Trp Ser Val Gly Arg 550555560 taggttgactg ttcaatgcgt tga 1812<210>288<211>563<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>288Val Gly Arg Ile Pro Arg Ala Lys Trp Trp Phe Leu Gly Ala Leu Val 151015 Leu Leu Ser Ala Gly Ala Tyr Ala Ser Val Leu Val Pro Gln Val Leu

20 25 30Gly Arg Ile Val Asp Leu Val Ser Asp Gly Ala Gln Met Arg Asp Phe

35 40 45Val Glu Leu Ser Val Ile Leu Ile Ala Val Ala Ile Ala Gly Ala Val

50 55 60Leu Ser Ala Cys Gly Phe Tyr Val Val Ser Arg Ile Ser Glu Lys Ile 65 70 75 80Ile Ala Asn Leu Arg Glu Asp Met Val Gly Thr Ala Leu Gly Leu Pro

85 90 95Thr His Gln Val Glu Asp Ala Gly Ser Gly Asp Leu Val Ser Arg Ser

100 105 110Thr Asp Asp Val Ser Glu Leu Ser Ala Ala Val Thr Glu Thr Val Pro

115 120 125Ile Leu Ser Ser Ser Leu Phe Thr Ile Ala Ala Thr Ile Ile Ala Leu

130 135 140Phe Ser Leu Asp Trp Gln Phe Val Leu Ile Pro Val Val Val Ala Pro145 150 155 160Val Tyr Tyr Phe Ala Ser Lys His Tyr Leu Ser Lys Ala Pro Asp Arg

165 170 175Tyr Ala Ala Glu Arg Ala Ala Met Ala Glu Arg Ala Arg Lys Val Leu

180 185 190Glu Ala Ile Arg Gly Arg Ala Thr Val Arg Ala Tyr Ser Met Glu Asp

195 200 205Ala Met His Asn Gln Ile Asp Gln Ala Ser Trp Ser Val Val Val Lys

210 215 220Gly Ile Arg Ala Arg Thr Thr Met Leu Ile Leu Asn Met Trp Met Leu225 230 235 240Phe Ala Glu Phe Leu Met Leu Ala Val Ala Leu Val Ile Gly Tyr Lys

245 250 255Leu Val Ile Asp Asn Ala Leu Thr Ile Gly Ala Val Thr Gly Ala Val

260 265 270Leu Met Ile Ile Arg Leu Arg Gly Pro Met Asn Met Phe Met Arg Val

275 280 285Leu Asp Thr Ile Gln Ser Gly Tyr Ala Ser Leu Ala Arg Ile Val Gly

290 295 300Val Val Ala Asp Pro Pro Ile Pro Val Pro Asp Ser Gly Val Lys Ala305 310 315 320Pro Gln Gly Lys Val Glu Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp

325 330 335Ser Trp Ala Val Lys Asp Ile Asp Ile Thr Ile Asn Ser Gly Glu Thr

340 345 350Val Ala Leu Val Gly Ala Ser Gly Ala Gly Lys Thr Thr Val Ala Ala

355 360 365Leu Leu Ala Gly Leu Arg Val Pro Asp Gln Gly Gln Val Leu Val Asp

370 375 380Asp Phe Pro Val Ser His Leu Ser Asp Arg Glu Arg Ile Ala Arg Leu385 390395 400Ala Met Val Ser Gln Glu Val His Val Phe Ser Gly Thr Leu Arg Gln

405 410 415Asp Leu Thr Leu Ala Lys Pro Asp Ala Ser Asp Glu Glu Leu Ala His

420 425 430Ala Leu Gly Gln Val Asn Ala Leu Asp Trp Leu Glu Ser Leu Pro Glu

435 440 445Gly Leu Asp Thr Val Val Gly Ala Arg Gly Ile Gln Leu Glu Pro Val

450 455 460Val Ala Gln Gln Leu Ala Leu Ala Arg Val Leu Leu Leu Asn Pro Ala465 470 475 480Ile Val Ile Met Asp Glu Ala Thr Ala Glu Ala Gly Ser Ala Gly Ala

485 490 495Ser Ala Leu Glu Glu Ala Ala Asp Ala Val Ser Lys Asn Arg Ser Ala

500 505 510Leu Val Val Ala His Arg Leu Asp Gln Ala Ser Arg Ala Asp Gln Ile

515 520 525Leu Val Met Asp Lys Gly Glu Val Val Glu Ser Gly Thr His Gln Glu

530535540 Leu Leu Asp His Gly Gly Ile Tyr Gln Arg Leu Trp Thr Ala Trp Ser 545550555560 Val Gly Arg<210>289<211>1812<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1789)<223>FRXA00164<400>289ctgctttgcg ggaggttatg aaatgagtgg ggagacgtcg aaaagcatgc gctttccgtt 60ggccagcctg ccgcaagtgc ggcgcgaggt ggcccggcag gtg ggt cgt att ccg 115

Val Gly Arg Ile Pro

1 5cgg gcg aag tgg tgg ttt tta ggc gcg ctg gtg ttg ctg agt gcg ggc 163Arg Ala Lys Trp Trp PheLeu Gly Ala Leu Val Leu Leu Ser Ala Gly

10 15 20gct tat gcg tcg gtg ctg gtg ccg cag gtg ctg ggg cgg att gtg gat 211Ala Tyr Ala Ser Val Leu Val Pro Gln Val Leu Gly Arg Ile Val Asp

25 30 35ctg gtg tcc gat ggc gcg cag atg cgt gat ttt gtt gag ctc agt gtg 259Leu Val Ser Asp Gly Ala Gln Met Arg Asp Phe Val Glu Leu Ser Val

40 45 50att ctc att gcg gtg gca att gcc ggc gcg gtg ctc agt gcg tgc ggg 307Ile Leu Ile Ala Val Ala Ile Ala Gly Ala Val Leu Ser Ala Cys Gly

55 60 65ttc tat gtg gtg tcg cgg att tct gag aag att atc gcc aat ttg agg 355Phe Tyr Val Val Ser Arg Ile Ser Glu Lys Ile Ile Ala Asn Leu Arg 70 75 80 85gaa gat atg gtg ggc acc gcg ctt ggg ttg ccc acg cac cag gtg gaa 403Glu Asp Met Val Gly Thr Ala Leu Gly Leu Pro Thr His Gln Val Glu

90 95 100gat gcg ggc tct ggc gat ttg gtg agc cgc tcc acc gat gat gtc tcc 451Asp Ala Gly Ser Gly Asp Leu Val Ser Arg Ser Thr Asp Asp Val Ser

105 110 115gag cta tcc gca gcg gtg aca gag acc gtc ccg att tta agt tcc tca 499Glu Leu Ser Ala Ala Val Thr Glu Thr Val Pro Ile Leu Ser Ser Ser

120 125 130ctg ttt acc att gcc gcg acg atc att gcg ctg ttt tct ttg gac tgg 547Leu Phe Thr Ile Ala Ala Thr Ile Ile Ala Leu Phe Ser Leu Asp Trp

135 140 145caa ttt gtg ctc att cct gtc gtg gtg gcg ccg gtg tac tac ttc gcg 595Gln Phe Val Leu Ile Pro Val Val Val Ala Pro Val Tyr Tyr Phe Ala150 155 160 165tcc aag cac tat ttg agc aag gcg ccg gat egg tat gcg gca gaa cgc 643Ser Lys His Tyr Leu Ser Lys Ala Pro Asp Arg Tyr Ala Ala Glu Arg

170 175 180gcg gcg atg gcg gag cgt gcg cga aag gta ctt gag gct att cgc ggg 691Ala Ala Met Ala Glu Arg Ala Arg Lys Val Leu Glu Ala Ile Arg Gly

185 190 195cgt gca act gtg cgg gcg tat tcc atg gaa gat gcc atg cat aat cag 739Arg Ala Thr Val Arg Ala Tyr Ser Met Glu Asp Ala Met His Asn Gln

200 205 210att gat cag gcg tcg tgg tct gtg gtg gte aag ggt att cgt gcg cgc 787Ile Asp Gln Ala Ser Trp Ser Val Val Val Lys Gly Ile Arg Ala Arg

215 220 225acc acc atg ttg att ttg aac atg tgg atg ctg ttt gcg gaa ttc ctc 835Thr Thr Met Leu Ile Leu Asn Met Trp Met Leu Phe Ala Glu Phe Leu230 235 240 245atg ctc gcg gtc gcg ttg gtg atc ggc tac aag ctg gtc att gat aat 883Met Leu Ala Val Ala Leu Val Ile Gly Tyr Lys Leu Val Ile Asp Asn

250 255 260gcg ctg acg atc ggc gcg gtt acc ggt gcc gtg ctg atg att att cgt 931Ala Leu Thr Ile Gly Ala Val Thr Gly Ala Val Leu Met Ile Ile Arg

265 270 275ctg cgt ggc ccg atg aat atg ttc atg cgc gtg ctc gac acc att caa 979Leu Arg Gly Pro Met Asn Met Phe Met Arg Val Leu Asp Thr Ile Gln

280 285 290tcc ggc tat gcg tcg ctg gcg cgc atc gtg gga gtt gtt gcg gat ccg 1027Ser Gly Tyr Ala Ser Leu Ala Arg Ile Val Gly Val Val Ala Asp Pro

295 300 305ccg att cct gtg ccc gac agc ggt gtg aaa gca cct cag ggc aaa gtg 1075Pro Ile Pro Val Pro Asp Ser Gly ValLys Ala Pro Gln Gly Lys Val310 315 320 325gaa ttg cgc aac gtc agc ttt agc tat ggc gat tcc tgg gcg gtg aaa 1123Glu Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp Ser Trp Ala Val Lys

330 335 340gac atc gac atc acg atc aat tcc ggc gaa act gtc gcg ctc gtg ggc 1171Asp Ile Asp Ile Thr Ile Asn Ser Gly Glu Thr Val Ala Leu Val Gly

345 350 355gca tct ggc gca ggt aag acg acg gtc gcc gcc ttg ctg gcg ggc ttg 1219Ala Ser Gly Ala Gly Lys Thr Thr Val Ala Ala Leu Leu Ala Gly Leu

360 365 370cgg gtg cca gat caa ggg caa gtg ctt gtc gac gac ttc ccc gtc tct 1267Arg Val Pro Asp Gln Gly Gln Val Leu Val Asp Asp Phe Pro Val Ser

375 380 385cac ctc tct gac cgc gag cgt atc gcc cgc ttg gcc atg gtc agc cag 1315His Leu Ser Asp Arg Glu Arg Ile Ala Arg Leu Ala Met Val Ser Gln390 395 400 405gag gtt cat gtt ttc tcc ggc acg ctg cgc cag gat ctc acc ttg gct 1363Glu Val His Val Phe Ser Gly Thr Leu Arg Gln Asp Leu Thr Leu Ala

410 415 420aaa cca gat gcc tcc gat gag gaa tta gcg cat gct ctt ggg caa gtt 1411Lys Pro Asp Ala Ser Asp Glu Glu Leu Ala His Ala Leu Gly Gln Val

425 430 435aat gcc ctt gac tgg ttg gag agt ctt cca gaa gga ctg gac acg gtc 1459Asn Ala Leu Asp Trp Leu Glu Ser Leu Pro Glu Gly Leu Asp Thr Val

440 445 450gtt ggt gcg cga gga atc cag cta gaa cca gtg gtg gct cag cag ttg 1507Val Gly Ala Arg Gly Ile Gln Leu Glu Pro Val Val Ala Gln Gln Leu

455 460465gcg ttg gcc cgg gtg ttg ttg ctc aat ccg gcg atc gtc atc atg gat 1555Ala Leu Ala Arg Val Leu Leu Leu Asn Pro Ala Ile Val Ile Met Asp470 475 480 485gaa gcc acg gca gaa gca gga tcg gcg ggt gcc agc gca ctg gaa gag 1603Glu Ala Thr Ala Glu Ala Gly Ser Ala Gly Ala Ser Ala Leu Glu Glu

490 495 500gct gca gat gca gtg agc aag aac cgt tcc gca ttg gtg gtg gcg cac 1651Ala Ala Asp Ala Val Ser Lys Asn Arg Ser Ala Leu Val Val Ala His

505 510 515cgg ttg gat cag gca tcg cgg gct gat cag att ctg gtg atg gat aag 1699Arg Leu Asp Gln Ala Ser Arg Ala Asp Gln Ile Leu Val Met Asp Lys

520 525 530ggg gag gtt gtg gaa tcc ggt act cac cag gag tta ttg gat cac ggg 1747Gly Glu Val Val Glu Ser Gly Thr His Gln Glu Leu Leu Asp His Gly

535540545 ggt att tat cag cgt ctg tgg act gcg tgg agt gtc gga aga 1789Gly Ile Tyr Gln Arg Leu Trp Thr Ala Trp Ser Val Gly Arg 550555560 taggttgactg ttcaatgcgt tga 1812<210>290<211>563<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>290Val Gly Arg Ile Pro Arg Ala Lys Trp Trp Phe Leu Gly Ala Leu Val 151015 Leu Leu Ser Ala Gly Ala Tyr Ala Ser Val Leu Val Pro Gln Val Leu

20 25 30Gly Arg Ile Val Asp Leu Val Ser Asp Gly Ala Gln Met Arg Asp Phe

35 40 45Val Glu Leu Ser Val Ile Leu Ile Ala Val Ala Ile Ala Gly Ala Val

50 55 60Leu Ser Ala Cys Gly Phe Tyr Val Val Ser Arg Ile Ser Glu Lys Ile 65 70 75 80Ile Ala Asn Leu Arg Glu Asp Met Val Gly Thr Ala Leu Gly Leu Pro

85 90 95Thr His Gln Val Glu Asp Ala Gly Ser Gly Asp Leu Val Ser Arg Ser

100 105 110Thr Asp Asp Val Ser Glu Leu Ser Ala Ala Val Thr Glu Thr Val Pro

115 120 125Ile Leu Ser Ser Ser Leu Phe Thr Ile Ala Ala Thr Ile Ile Ala Leu

130 135 140Phe Ser Leu Asp Trp Gln Phe Val Leu Ile Pro Val Val Val Ala Pro145 150 155 160Val Tyr Tyr Phe Ala Ser Lys His Tyr Leu Ser Lys Ala Pro Asp Arg

165 170 175Tyr Ala Ala Glu Arg Ala Ala Met Ala Glu Arg Ala Arg Lys Val Leu

180 185 190Glu Ala Ile Arg Gly Arg Ala Thr Val Arg Ala Tyr Ser Met Glu Asp

195 200 205Ala Met His Asn Gln Ile Asp Gln Ala Ser Trp Ser Val Val Val Lys

210 215 220Gly Ile Arg Ala Arg Thr Thr Met Leu Ile Leu Asn Met Trp Met Leu225 230 235 240Phe Ala Glu Phe Leu Met Leu Ala Val Ala Leu Val Ile Gly Tyr Lys

245 250 255Leu Val Ile Asp Asn Ala Leu Thr Ile Gly Ala Val Thr Gly Ala Val

260 265 270Leu Met Ile Ile Arg Leu Arg Gly Pro Met Asn Met Phe Met Arg Val

275 280 285Leu Asp Thr Ile Gln Ser Gly Tyr Ala Ser Leu Ala Arg Ile Val Gly

290 295 300Val Val Ala Asp Pro Pro Ile Pro Val Pro Asp Ser Gly Val Lys Ala305310 315 320Pro Gln Gly Lys Val Glu Leu Arg Asn Val Ser Phe Ser Tyr Gly Asp

325 330 335Ser Trp Ala Val Lys Asp Ile Asp Ile Thr Ile Asn Ser Gly Glu Thr

340 345 350Val Ala Leu Val Gly Ala Ser Gly Ala Gly Lys Thr Thr Val Ala Ala

355 360 365Leu Leu Ala Gly Leu Arg Val Pro Asp Gln Gly Gln Val Leu Val Asp

370 375 380Asp Phe Pro Val Ser His Leu Ser Asp Arg Glu Arg Ile Ala Arg Leu385 390 395 400Ala Met Val Ser Gln Glu Val His Val Phe Ser Gly Thr Leu Arg Gln

405 410 415Asp Leu Thr Leu Ala Lys Pro Asp Ala Ser Asp Glu Glu Leu Ala His

420 425 430Ala Leu Gly Gln Val Asn Ala Leu Asp Trp Leu Glu Ser Leu Pro Glu

435 440 445Gly Leu Asp Thr Val Val Gly Ala Arg Gly Ile Gln Leu Glu Pro Val

450 455 460Val Ala Gln Gln Leu Ala Leu Ala Arg Val Leu Leu Leu Asn Pro Ala465 470 475 480Ile Val Ile Met Asp Glu Ala Thr Ala Glu Ala Gly Ser Ala Gly Ala

485 490 495Ser Ala Leu Glu Glu Ala Ala Asp Ala Val Ser Lys Asn Arg Ser Ala

500 505 510Leu Val Val Ala His Arg Leu Asp Gln Ala Ser Arg Ala Asp Gln Ile

515 520 525Leu Val Met Asp Lys Gly Glu Val Val Glu Ser Gly Thr His Gln Glu

530535540 Leu Leu Asp His Gly Gly Ile Tyr Gln Arg Leu Trp Thr Ala Trp Ser 545550555560 Val Gly Arg<210>291<211>1140<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1117)<223>RXN00243<400>291cactgcgcca gatttttgat gccgacactg tggcaggtgt gcgcgctgag tacgaaaaat 60ttaacaaagc agcccatgat ggaaatgaag aggaacagaa gtg acc agc gaa caa 115

Val Thr Ser Glu Gln

1 5gct tta gat cct atc cac cca ggt cag ttc cgt ctt tct cgg att cag 163Ala Leu Asp Pro Ile His Pro Gly Gln Phe Arg Leu Ser Arg Ile Gln

10 15 20ttg atc aac tgg gga acc ttc cac gga acg gtg gac att cct gtg acc 211Leu Ile Asn Trp Gly Thr Phe His Gly Thr Val Asp Ile Pro Val Thr

25 30 35agg gaa gga atc tta gtt acc ggt ggt tcg gga tca gga aaa tcc acg 259Arg Glu Gly Ile Leu Val Thr Gly Gly Ser Gly Ser Gly Lys Ser Thr

40 45 50ctg att gat gcg atc acg gcg gta ttg ctt ccg caa gga aag ctg agg 307Leu Ile Asp Ala Ile Thr Ala Val Leu Leu Pro Gln Gly Lys Leu Arg

55 60 65ttt aac tct gcc gca cag gct aat act ccg cgg aat aag gga cgc agt 355Phe Asn Ser Ala Ala Gln Ala Asn Thr Pro Arg Asn Lys Gly Arg Ser 70 75 80 85ttg gtt acc tat atc cgt ggc gct tgg cgt gcg cag gag gat ccg ctg 403Leu Val Thr Tyr Ile Arg Gly Ala Trp Arg Ala Gln Glu Asp Pro Leu

90 95 100cag gat cag att gtc tcc acg tac cta cgt ccc cgc gca acc tat tcg 451Gln Asp Gln Ile Val Ser Thr Tyr Leu Arg Pro Arg Ala Thr Tyr Ser

105 110 115ctg gtt gga ttg act tat tcc aac ggt gaa ggc gtc gag cac acc ttg 499Leu Val Gly Leu Thr Tyr Ser Ash Gly Glu Gly Val Glu His Thr Leu

120 125 130gtg gct att ttc tat ctg aaa tcg gga cac aat tta acc tcc gat att 547Val Ala Ile Phe Tyr Leu Lys Ser Gly His Asn Leu Thr Ser Asp Ile

135 140 145tct tca tat tat ggt gtg ttt ccc gtt gat caa gac atc aat gcg ctg 595Ser Ser Tyr Tyr Gly Val Phe Pro Val Asp Gln Asp Ile Asn Ala Leu150 155 160 165ctg gat ttc ctg aaa gag ggc atc gat aaa cgc cag atc aga gct gct 643Leu Asp Phe Leu Lys Glu Gly Ile Asp Lys Arg Gln Ile Arg Ala Ala

170 175 180ttc aag gaa gcc atc ttt agc gag cag cat tct gta ttc tcc ggc agg 691Phe Lys Glu Ala Ile Phe Ser Glu Gln His Ser Val Phe Ser Gly Arg

185 190 195ttt aga agc cgt ttg ggg atc tcc agt gag gaa gct ttg ctg ttg ttg 739Phe Arg Ser Arg Leu Gly Ile Ser Ser Glu Glu Ala Leu Leu Leu Leu

200 205 210cac cgc gcg cag tcg gcg aaa gat ctt caa agc ttg gat gat cta ttt 787His Arg Ala Gln Ser Ala Lys Asp Leu Gln Ser Leu Asp Asp Leu Phe

215 220 225cgg gat tac atg ctg gtg gaa ccg gat acg ttc agc att gcc aaa act 835Arg Asp Tyr Met Leu Val Glu Pro Asp Thr Phe Ser Ile Ala Lys Thr230 235 240 245gcc gtg gaa caa ttc caa gac ctt gaa ggt gct tat gag cag gtc gaa 883Ala Val Glu Gln Phe Gln Asp Leu Glu Gly Ala Tyr Glu Gln Val Glu

250 255 260gat att aaa cgg cag atc cac acc ctg gat cct ttg gtg cag ctg aag 931Asp Ile Lys Arg Gln Ile His Thr Leu Asp Pro Leu Val Gln Leu Lys

265 270 275aat cgg cga gag aaa gcg caa cag tcc aaa gat cat gcc aat gca ctg 979Asn Arg Arg Glu Lys Ala Gln Gln Ser Lys Asp His Ala Asn Ala Leu

280 285 290aag aag gcg ctg ccg act gtc ggg aat cgc att aag aag gaa gag caa 1027Lys Lys Ala Leu Pro Thr Val Gly Asn Arg Ile Lys Lys Glu Glu Gln

295 300 305gaa ccg ctg gtt cga caa ttt act gtc gag caa acg cag cga agt cga 1075Glu Pro Leu Val Arg Gln Phe Thr Val Glu Gln Thr Gln Arg Ser Arg310 315 320 325agg tgg agt ccg cca aaa ttg aga cag atc gtg ccc gcg aaa 1117Arg Trp Ser Pro Pro Lys Leu Arg Gln Ile Val Pro Ala Lys

330335 tgaaaaccct cgcgcacgac aac 1140<210>292<211>339<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>292Val Thr Ser Glu Gln Ala Leu Asp Pro Ile His Pro Gly Gln Phe Arg 151015 Leu Ser Arg Ile Gln Leu Ile Asn Trp Gly Thr Phe His Gly Thr Val

20 25 30Asp Ile Pro Val Thr Arg Glu Gly Ile Leu Val Thr Gly Gly Ser Gly

35 40 45Ser Gly Lys Ser Thr Leu Ile Asp Ala Ile Thr Ala Val Leu Leu Pro

50 55 60Gln Gly Lys Leu Arg Phe Asn Ser Ala Ala Gln Ala Asn Thr Pro Arg 65 70 75 80Asn Lys Gly Arg Ser Leu Val Thr Tyr Ile Arg Gly Ala Trp Arg Ala

85 90 95Gln Glu Asp Pro Leu Gln Asp Gln Ile Val Ser Thr Tyr Leu Arg Pro

100 105 110Arg Ala Thr Tyr Ser Leu Val Gly Leu Thr Tyr Ser Asn Gly Glu Gly

115 120 125Val Glu His Thr Leu Val Ala Ile Phe Tyr Leu Lys Ser Gly His Asn

130 135 140Leu Thr Ser Asp Ile Ser Ser Tyr Tyr Gly Val Phe Pro Val Asp Gln145 150 155 160Asp Ile Asn Ala Leu Leu Asp Phe Leu Lys Glu Gly Ile Asp Lys Arg

165 170 175Gln Ile Arg Ala Ala Phe Lys Glu Ala Ile Phe Ser Glu Gln His Ser

180 185 190Val Phe Ser Gly Arg Phe Arg Ser Arg Leu Gly Ile Ser Ser Glu Glu

195 200 205Ala Leu Leu Leu Leu His Arg Ala Gln Ser Ala Lys Asp Leu Gln Ser

210 215 220Leu Asp Asp Leu Phe Arg Asp Tyr Met Leu Val Glu Pro Asp Thr Phe225 230 235 240Ser Ile Ala Lys Thr Ala Val Glu Gln Phe Gln Asp Leu Glu Gly Ala

245 250 255Tyr Glu Gln Val Glu Asp Ile Lys Arg Gln Ile His Thr Leu Asp Pro

260 265 270Leu Val Gln Leu Lys Asn Arg Arg Glu Lys Ala Gln Gln Ser Lys Asp

275 280 285His Ala Asn Ala Leu Lys Lys Ala Leu Pro Thr Val Gly Asn Arg Ile

290 295 300Lys Lys Glu Glu Gln Glu Pro Leu Val Arg Gln Phe Thr Val Glu Gln305 310 315 320Thr Gln Arg Ser Arg Arg Trp Ser Pro Pro Lys Leu Arg Gln Ile Val

325330335 Pro Ala Lys<210>293<211>1027<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1027)<223>FRXA00243<400>293cactgcgcca gatttttgat gccgacactg tggcaggtgt gcgcgctgag tacgaaaaat 60ttaacaaagc agcccatgat ggaaatgaag aggaacagaa gtg acc agc gaa caa 115

Val Thr Ser Glu Gln

1 5gct tta gat cct atc cac cca ggt cag ttc cgt ctt tct cgg att cag 163Ala Leu Asp Pro Ile His Pro Gly Gln Phe Arg Leu Ser Arg Ile Gln

10 15 20ttg atc aac tgg gga acc ttc cac gga acg gtg gac att cct gtg acc 211Leu Ile Asn Trp Gly Thr Phe His Gly Thr Val Asp Ile Pro Val Thr

25 30 35agg gaa gga atc tta gtt acc ggt ggt tcg gga tca gga aaa tcc acg 259Arg Glu Gly Ile Leu Val Thr Gly Gly Ser Gly Ser Gly Lys Ser Thr

40 45 50ctg att gat gcg atc acg gcg gta ttg ctt ccg caa gga aag ctg agg 307Leu Ile Asp Ala Ile Thr Ala Val Leu Leu Pro Gln Gly Lys Leu Arg

55 60 65ttt aac tct gcc gca cag gct aat act ccg cgg aat aag gga cgc agt 355Phe Asn Ser Ala Ala Gln Ala Asn Thr Pro Arg Asn Lys Gly Arg Ser 70 75 80 85ttg gtt acc tat atc cgt ggc gct tgg cgt gcg cag gag gat ccg ctg 403Leu Val Thr Tyr Ile Arg Gly Ala Trp Arg Ala Gln Glu Asp Pro Leu

90 95 100cag gat cag att gtc tcc acg tac cta cgt ccc cgc gca acc tat tcg 451Gln Asp Gln Ile Val Ser Thr Tyr Leu Arg Pro Arg Ala Thr Tyr Ser

105 110115ctg gtt gga ttg act tat tcc aac ggt gaa ggc gtc gag cac acc ttg 499Leu Val Gly Leu Thr Tyr Ser Asn Gly Glu Gly Val Glu His Thr Leu

120 125 130gtg gct att ttc tat ctg aaa tcg gga cac aat tta acc tcc gat att 547Val Ala Ile Phe Tyr Leu Lys Ser Gly His Asn Leu Thr Ser Asp Ile

135 140 145tct tca tat tat ggt gtg ttt ccc gtt gat caa gac atc aat gcg ctg 595Ser Ser Tyr Tyr Gly Val Phe Pro Val Asp Gln Asp Ile Asn Ala Leu150 155 160 165ctg gat ttc ctg aaa gag ggc atc gat aaa cgc cag atc aga gct gct 643Leu Asp Phe Leu Lys Glu Gly Ile Asp Lys Arg Gln Ile Arg Ala Ala

170 175 180ttc aag gaa gcc atc ttt agc gag cag cat tct gta ttc tcc ggc agg 691Phe Lys Glu Ala Ile Phe Ser Glu Gln His Ser Val Phe Ser Gly Arg

185 190 195ttt aga agc cgt ttg ggg atc tcc agt gag gaa gct ttg ctg ttg ttg 739Phe Arg Ser Arg Leu Gly Ile Ser Ser Glu Glu Ala Leu Leu Leu Leu

200 205 210cac cgc gcg cag tcg gcg aaa gat ctt caa agc ttg gat gat cta ttt 787His Arg Ala Gln Ser Ala Lys Asp Leu Gln Ser Leu Asp Asp Leu Phe

215 220 225cgg gat tac atg ctg gtg gaa ccg gat acg ttc agc att gcc aaa act 835Arg Asp Tyr Met Leu Val Glu Pro Asp Thr Phe Ser Ile Ala Lys Thr230 235 240 245gcc gtg gaa caa ttc caa gac ctt gaa ggt gct tat gag cag gtc gaa 883Ala Val Glu Gln Phe Gln Asp Leu Glu Gly Ala Tyr Glu Gln Val Glu

250 255 260gat att aaa cgg cag atc cac acc ctg gat cct ttg gtg cag ctg aag 931Asp Ile Lys Arg Gln Ile His Thr Leu Asp Pro Leu Val Gln Leu Lys

265 270 275aat cgg cga gag aaa gcg caa cag tcc aaa gat cat gcc aat gca ctg 979Asn Arg Arg Glu Lys Ala Gln Gln Ser Lys Asp His Ala Asn Ala Leu

280 285 290aag aag gcg ctg ccg act gtc ggg aat cgc att aag aag gaa gag caa 1027Lys Lys Ala Leu Pro Thr Val Gly Asn Arg Ile Lys Lys Glu Glu Gln

295300305<210>294<211>309<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>294Val Thr Ser Glu Gln Ala Leu Asp Pro Ile His Pro Gly Gln Phe Arg 151015 Leu Ser Arg Ile Gln Leu Ile Asn Trp Gly Thr Phe His Gly Thr Val

20 25 30Asp Ile Pro Val Thr Arg Glu Gly Ile Leu Val Thr Gly Gly Ser Gly

35 40 45Ser Gly Lys Ser Thr Leu Ile Asp Ala Ile Thr Ala Val Leu Leu Pro

50 55 60Gln Gly Lys Leu Arg Phe Asn Ser Ala Ala Gln Ala Asn Thr Pro Arg 65 70 75 80Asn Lys Gly Arg Ser Leu Val Thr Tyr Ile Arg Gly Ala Trp Arg Ala

85 90 95Gln Glu Asp Pro Leu Gln Asp Gln Ile Val Ser Thr Tyr Leu Arg Pro

100 105 110Arg Ala Thr Tyr Ser Leu Val Gly Leu Thr Tyr Ser Asn Gly Glu Gly

115 120 125Val Glu His Thr Leu Val Ala Ile Phe Tyr Leu Lys Ser Gly His Asn

130 135 140Leu Thr Ser Asp Ile Ser Ser Tyr Tyr Gly Val Phe Pro Val Asp Gln145 150 155 160Asp Ile Asn Ala Leu Leu Asp Phe Leu Lys Glu Gly Ile Asp Lys Arg

165 170 175Gln Ile Arg Ala Ala Phe Lys Glu Ala Ile Phe Ser Glu Gln His Ser

180 185 190Val Phe Ser Gly Arg Phe Arg Ser Arg Leu Gly Ile Ser Ser Glu Glu

195 200 205Ala Leu Leu Leu Leu His Arg Ala Gln Ser Ala Lys Asp Leu Gln Ser

210 215 220Leu Asp Asp Leu Phe Arg Asp Tyr Met Leu Val Glu Pro Asp Thr Phe225 230 235 240Ser Ile Ala Lys Thr Ala Val Glu Gln Phe Gln Asp Leu Glu Gly Ala

245 250 255Tyr Glu Gln Val Glu Asp Ile Lys Arg Gln Ile His Thr Leu Asp Pro

260 265 270Leu Val Gln Leu Lys Asn Arg Arg Glu Lys Ala Gln Gln Ser Lys Asp

275 280 285His Ala Asn Ala Leu Lys Lys Ala Leu Pro Thr Val Gly Ash Arg Ile

290295300 Lys Lys Glu Glu Gln<305>295<211>2325<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).)

Met Ser Gly Leu Phe

1 5acc cca ttt tca gat gcg gca aaa aac aac acg gta aaa act gat gga 162Thr Pro Phe Ser Asp Ala Ala Lys Asn Asn Thr Val Lys Thr Asp Gly

10 15 20gat tca gta tct ggt cga gac ttg cct att act aag atc tct gag gat 211Asp Ser Val Ser Gly Arg Asp Leu Pro Ile Thr Lys Ile Ser Glu Asp

25 3035cgt ttc gag cgt tct gcg tat tca gcc cag ctg gca aat ata atc tgc 259Arg Phe Glu Arg Ser Ala Tyr Ser Ala Gln Leu Ala Asn Ile Ile Cys

40 45 50gat gtg gca cct tgg gga gcg agc act gtt ttc agt ctt act ggt cag 307Asp Val Ala Pro Trp Gly Ala Ser Thr Val Phe Ser Leu Thr Gly Gln

55 60 65tgg ggc agt ggt aag aca tct ctt gtt aat ttg att cgc tcg gaa gaa 355Trp Gly Ser Gly Lys Thr Ser Leu Val Asn Leu Ile Arg Ser Glu Glu 70 75 80 85tct cta tcg aac gaa aaa tgg aca atc gtt gat ttc aac ccg tgg gtg 403Ser Leu Ser Asn Glu Lys Trp Thr Ile Val Asp Phe Asn Pro Trp Val

90 95 100gcc tct gac ccg caa tct ttg att gag gag ttt tac cga gta atc gtt 451Ala Ser Asp Pro Gln Ser Leu Ile Glu Glu Phe Tyr Arg Val Ile Val

105 110 115ggg acg gta cct gat gat aag acc ggc caa aag atc aaa act gtt ctg 499Gly Thr Val Pro Asp Asp Lys Thr Gly Gln Lys Ile Lys Thr Val Leu

120 125 130cag aaa acc ttt agc acg att ggg tca att gca ggt ggg gtc gga ggg 547Gln Lys Thr Phe Ser Thr Ile Gly Ser Ile Ala Gly Gly Val Gly Gly

135 140 145ttt ggt gtc cta gaa gca ctt gcg ctc tca aaa gga gta gat gct gca 595Phe Gly Val Leu Glu Ala Leu Ala Leu Ser Lys Gly Val Asp Ala Ala150 155 160 165aac gct gta tat aag aca tgg aaa cag gag caa gat tcg tgg cca acg 643Asn Ala Val Tyr Lys Thr Trp Lys Gln Glu Gln Asp Ser Trp Pro Thr

170 175 180ctg tat aca cgt gct gcg aac cat ttt aaa gat ctg aac aag cga att 691Leu Tyr Thr Arg Ala Ala Asn His Phe Lys Asp Leu Asn Lys Arg Ile

185 190 195ctc att gtc gtc gat gat att gat cgc ctc cat act gat gaa ttg gcg 739Leu Ile Val Val Asp Asp Ile Asp Arg Leu His Thr Asp Glu Leu Ala

200 205 210ctg tta atg aaa gta ata cgc ttg ctt gga cga ttc ccg cag gtg aat 787Leu Leu Met Lys Val Ile Arg Leu Leu Gly Arg Phe Pro Gln Val Asn

215 220 225tat ctt ttg gtt tat gaa gaa gaa tca ctg tta acg acg cta gcc aga 835Tyr Leu Leu Val Tyr Glu Glu Glu Ser Leu Leu Thr Thr Leu Ala Arg230 235 240 245tcg aca gct gta ggt ggt agc gaa gat gat gct ttg cgt ttc atg gag 883Ser Thr Ala Val Gly Gly Ser Glu Asp Asp Ala Leu Arg Phe Met Glu

250 255 260aaa atc gtg cag tat cct ttc gat gtt ccg cct ctg aca tca ttt caa 931Lys Ile Val Gln Tyr Pro Phe Asp Val Pro Pro Leu Thr Ser Phe Gln

265 270 275ata gag aaa gag ctc agt gca tta ttt gac aag ctt ttc cag ggt gtt 979Ile Glu Lys Glu Leu Ser Ala Leu Phe Asp Lys Leu Phe Gln Gly Val

280 285 290tcg cta tcg ggt gat cct gaa gac ttt gca cta gtg aag tcg aga atg 1027Ser Leu Ser Gly Asp Pro Glu Asp Phe Ala Leu Val Lys Ser Arg Met

295 300 305ttc gat gtc tgg gaa aag act ctg gtc acg ccg agg ctg ttg cac cgt 1075Phe Asp Val Trp Glu Lys Thr Leu Val Thr Pro Arg Leu Leu His Arg310 315 320 325ttt gct gct cta cta acc aac tgg act cgg ata tat gga tca ggt gaa 1123Phe Ala Ala Leu Leu Thr Asn Trp Thr Arg Ile Tyr Gly Ser Gly Glu

330 335340gtt aac ggc gtt gat ctc aca ata ctt gcg acc att cga att gtt ttt 1171Val Asn Gly Val Asp Leu Thr Ile Leu Ala Thr Ile Arg Ile Val Phe

345 350 355ccg tct gtg tat aaa cgt ctt tct cga gcg aag gaa gta ttg ctt caa 1219Pro Ser Val Tyr Lys Arg Leu Ser Arg Ala Lys Glu Val Leu Leu Gln

360 365 370gga ggt cga acg aca ggc tcg cag aaa ccc ggt tgg gaa aag caa tta 1267Gly Gly Arg Thr Thr Gly Ser Gln Lys Pro Gly Trp Glu Lys Gln Leu

375 380 385tgt gag ggg atg aac aac gag cag atg gat ctt tta aag acc atg ctt 1315Cys Glu Gly Met Asn Asn Glu Gln Met Asp Leu Leu Lys Thr Met Leu390 395 400 405ttg ttc ctt ttc cca cgt ctt tcg gat cac cct agt acg aga atg cat 1363Leu Phe Leu Phe Pro Arg Leu Ser Asp His Pro Ser Thr Arg Met His

410 415 420cgt gag agg ggg atc tcg acg gaa gtt tat ttt gac acg tac ctc atg 1411Arg Glu Arg Gly Ile Ser Thr Glu Val Tyr Phe Asp Thr Tyr Leu Met

425 430 435ttt caa aga cct gga cat gtc ata agt gat gaa cag ttg gat aag tat 1459Phe Gln Arg Pro Gly His Val Ile Ser Asp Glu Gln Leu Asp Lys Tyr

440 445 450cta tct aat gcg gac gat gct atg ggt ttc gtc gat tta att aac tcc 1507Leu Ser Asn Ala Asp Asp Ala Met Gly Phe Val Asp Leu Ile Asn Ser

455 460 465gat gac aat gac atg gtg gca tca gtg atg aaa aag ctt cct cta gca 1555Asp Asp Asn Asp Met Val Ala Ser Val Met Lys Lys Leu Pro Leu Ala470 475 480 485att gat cga ctt gat gga gag ggt gtt agg cac atg gca gtt gag gtg 1603Ile Asp Arg Leu Asp Gly Glu Gly Val Arg His Met Ala Val Glu Val

490 495 500tta ttc acc gct gct aat ggt atg cat gat aaa ggt cgt caa gtg cgt 1651Leu Phe Thr Ala Ala Asn Gly Met His Asp Lys Gly Arg Gln Val Arg

505 510 515atg agc ggc ata ttc agt gac ctg tat tcc cat gcg tgc tcg att ctt 1699Met Ser Gly Ile Phe Ser Asp Leu Tyr Ser His Ala Cys Ser Ile Leu

520 525 530ggt gca ttg cct caa tta cca gtg gaa caa ctc tat gag aaa ttc ttt 1747Gly Ala Leu Pro Gln Leu Pro Val Glu Gln Leu Tyr Glu Lys Phe Phe

535 540 545tct gag atg acg ctt aat gag gct gct ttc tgg tta aac cag gtg ggg 1795Ser Glu Met Thr Leu Asn Glu Ala Ala Phe Trp Leu Asn Gln Val Gly550 555 560 565gaa agg gct aga gcc tgt ggt aat gat gta agt ggc ctt gag ctt ttt 1843Glu Arg Ala Arg Ala Cys Gly Asn Asp Val Ser Gly Leu Glu Leu Phe

570 575 580cgt aaa gtt aat ata aag acc gaa gct aga att tta agt gta ttg aag 1891Arg Lys Val Asn Ile Lys Thr Glu Ala Arg Ile Leu Ser Val Leu Lys

585 590 595aat cag gac ccc tca gat tgg gat tta ggt cca tat tcg ctt ggt att 1939Asn Gln Asp Pro Ser Asp Trp Asp Leu Gly Pro Tyr Ser Leu Gly Ile

600 605 610ttg gcg aaa agc tcg aat ttt tct tca gtg ctg aag tct ctg caa agt 1987Leu Ala Lys Ser Ser Asn Phe Ser Ser Val Leu Lys Ser Leu Gln Ser

615 620 625ggt ata gag gaa cat cag ttt gat gtg ata gat att gga gtg ctt ttc 2035Gly Ile Glu Glu His Gln Phe Asp Val Ile Asp Ile Gly Val Leu Phe630 635 640 645tta acg act gtg tattct tcg cga cag gga cca agc ggt ggt gca tgg 2083Leu Thr Thr Val Tyr Ser Ser Arg Gln Gly Pro Ser Gly Gly Ala Trp

650 655 660ata gat tct ttt cag cat agt ctg ttt tca cgg tac gta cct gat tct 2131Ile Asp Ser Phe Gln His Ser Leu Phe Ser Arg Tyr Val Pro Asp Ser

665 670 675cta cgg gct ata acc aag tct gaa gta gat gta gaa cta ggt aag ata 2179Leu Arg Ala Ile Thr Lys Ser Glu Val Asp Val Glu Leu Gly Lys Ile

680 685 690cag ttc acg gat ttt agc tgg gaa ggg aag cga aaa gtt gtc gca tat 2227Gln Phe Thr Asp Phe Ser Trp Glu Gly Lys Arg Lys Val Val Ala Tyr

695 700 705gca ctg gag act gga aga agt gat ttc act cga gaa cga tta ggg ggc 2275Ala Leu Glu Thr Gly Arg Ser Asp Phe Thr Arg Glu Arg Leu Gly Gly710 715 720 725tac agt atc gca gat tct ata gtc gat tgatgaggct gaggtcatga 2322Tyr Ser Ile Ala Asp Ser Ile Val Asp

730ctt2325<210>296<211>734<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>296Met Ser Gly Leu Phe Thr Pro Phe Ser Asp Ala Ala Lys Asn Asn Thr 151015 Val Lys Thr Asp Gly Asp Ser Val Ser Gly Arg Asp Leu Pro Ile Thr

20 25 30Lys Ile Ser Glu Asp Arg Phe Glu Arg Ser Ala Tyr Ser Ala Gln Leu

35 40 45Ala Asn Ile Ile Cys Asp Val Ala Pro Trp Gly Ala Ser Thr Val Phe

50 55 60Ser Leu Thr Gly Gln Trp Gly Ser Gly Lys Thr Ser Leu Val Asn Leu 65 70 75 80Ile Arg Ser Glu Glu Ser Leu Ser Asn Glu Lys Trp Thr Ile Val Asp

85 90 95Phe Asn Pro Trp Val Ala Ser Asp Pro Gln Ser Leu Ile Glu Glu Phe

100 105 110Tyr Arg Val Ile Val Gly Thr Val Pro Asp Asp Lys Thr Gly Gln Lys

115 120 125Ile Lys Thr Val Leu Gln Lys Thr Phe Ser Thr Ile Gly Ser Ile Ala

130 135 140Gly Gly Val Gly Gly Phe Gly Val Leu Glu Ala Leu Ala Leu Ser Lys145 150 155 160Gly Val Asp Ala Ala Asn Ala Val Tyr Lys Thr Trp Lys Gln Glu Gln

165 170 175Asp Ser Trp Pro Thr Leu Tyr Thr Arg Ala Ala Asn His Phe Lys Asp

180 185 190Leu Asn Lys Arg Ile Leu Ile Val Val Asp Asp Ile Asp Arg Leu His

195 200 205Thr Asp Glu Leu Ala Leu Leu Met Lys Val Ile Arg Leu Leu Gly Arg

210 215 220Phe Pro Gln Val Asn Tyr Leu Leu Val Tyr Glu Glu Glu Ser Leu Leu225 230 235 240Thr Thr Leu Ala Arg Ser Thr Ala Val Gly Gly Ser Glu Asp Asp Ala

245 250 255Leu Arg Phe Met Glu Lys Ile Val Gln Tyr Pro Phe Asp Val Pro Pro

260 265 270Leu Thr Ser Phe Gln Ile Glu Lys Glu Leu Ser Ala Leu Phe Asp Lys

275 280 285Leu Phe Gln Gly Val Ser Leu Ser Gly Asp Pro Glu Asp Phe Ala Leu

290 295 300Val Lys Ser Arg Met Phe Asp Val Trp Glu Lys Thr Leu Val Thr Pro305 310 315 320Arg Leu Leu His Arg Phe Ala Ala Leu Leu Thr Asn Trp Thr Arg Ile

325 330 335Tyr Gly Ser Gly Glu Val Asn Gly Val Asp Leu Thr Ile Leu Ala Thr

340 345 350Ile Arg Ile Val Phe Pro Ser Val Tyr Lys Arg Leu Ser Arg Ala Lys

355 360 365Glu Val Leu Leu Gln Gly Gly Arg Thr Thr Gly Ser Gln Lys Pro Gly

370 375 380Trp Glu Lys Gln Leu Cys Glu Gly Met Asn Asn Glu Gln Met Asp Leu385 390 395 400Leu Lys Thr Met Leu Leu Phe Leu Phe Pro Arg Leu Ser Asp His Pro

405 410 415Ser Thr Arg Met His Arg Glu Arg Gly Ile Ser Thr Glu Val Tyr Phe

420 425 430Asp Thr Tyr Leu Met Phe Gln Arg Pro Gly His Val Ile Ser Asp Glu

435 440 445Gln Leu Asp Lys Tyr Leu Ser Asn Ala Asp Asp Ala Met Gly Phe Val

450 455 460Asp Leu Ile Asn Ser Asp Asp Asn Asp Met Val Ala Ser Val Met Lys465 470 475 480Lys Leu Pro Leu Ala Ile Asp Arg Leu Asp Gly Glu Gly Val Arg His

485 490 495Met Ala Val Glu Val Leu Phe Thr Ala Ala Asn Gly Met His Asp Lys

500 505 510Gly Arg Gln Val Arg Met Ser Gly Ile Phe Ser Asp Leu Tyr Ser His

515 520 525Ala Cys Ser Ile Leu Gly Ala Leu Pro Gln Leu Pro Val Glu Gln Leu

530 535 540Tyr Glu Lys Phe Phe Ser Glu Met Thr Leu Asn Glu Ala Ala Phe Trp545 550 555 560Leu Asn Gln Val Gly Glu Arg Ala Arg Ala Cys Gly Asn Asp Val Ser

565 570 575Gly Leu Glu Leu Phe Arg Lys Val Asn Ile Lys Thr Glu Ala Arg Ile

580 585 590Leu Ser Val Leu Lys Asn Gln Asp Pro Ser Asp Trp Asp Leu Gly Pro

595 600 605Tyr Ser Leu Gly Ile Leu Ala Lys Ser Ser Asn Phe Ser Ser Val Leu

610 615 620Lys Ser Leu Gln Ser Gly Ile Glu Glu His Gln Phe Asp Val Ile Asp625 630 635 640Ile Gly Val Leu Phe Leu Thr Thr Val Tyr Ser Ser Arg Gln Gly Pro

645 650 655Ser Gly Gly Ala Trp Ile Asp Ser Phe Gln His Ser Leu Phe Ser Arg

660 665 670Tyr Val Pro Asp Ser Leu Arg Ala Ile Thr Lys Ser Glu Val Asp Val

675 680 685Glu Leu Gly Lys Ile Gln Phe Thr Asp Phe Ser Trp Glu Gly Lys Arg

690 695 700Lys Val Val Ala Tyr Ala Leu Glu Thr Gly Arg Ser Asp Phe Thr Arg705 710 715 720Glu Arg Leu Gly Gly Tyr Ser Ile Ala Asp Ser Ile Val Asp

725730<210>297<211>789<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (766)<223>RXN00410<400>297gtgttgatgc gttagtccac ccacgcagct acgccccaaa ggaataatct tgaaccctgc 60cacagataac gctccgccgg tcctttcagc ccaagatctc atg atgatc tat gga 115

Met Met Ile Tyr Gly

1 5aaa gga tca aca gaa gtt cgg gct ctc gat ggc att tct gta cag att 163Lys Gly Ser Thr Glu Val Arg Ala Leu Asp Gly Ile Ser Val Gln Ile

10 15 20cag tcc gac aaa tgg acc tcc atc atg ggg caa tca ggc tct ggc aaa 211Gln Ser Asp Lys Trp Thr Ser Ile Met Gly Gln Ser Gly Ser Gly Lys

25 30 35aca act ctg ttg cag tgc ctt tcc gga ttg gcg cag cca acc tca ggc 259Thr Thr Leu Leu Gln Cys Leu Ser Gly Leu Ala Gln Pro Thr Ser Gly

40 45 50aga gtg aca ctg aac aaa aac aac atc acg ttg agc tcc ctg tca gaa 307Arg Val Thr Leu Asn Lys Asn Asn Ile Thr Leu Ser Ser Leu Ser Glu

55 60 65aat aag cgt gcc aag ctg cgt cgc acg cac atc agc atg gtg ttt cag 355Asn Lys Arg Ala Lys Leu Arg Arg Thr His Ile Ser Met Val Phe Gln 70 75 80 85gat ttc aac ttg gtg cct att ttg tcg gtg aag gac aat att ttg ctg 403Asp Phe Asn Leu Val Pro Ile Leu Ser Val Lys Asp Asn Ile Leu Leu

90 95 100ccg ttg cgt ctt gcg cat cgc agg gtg gat aag cag tgg ttt gaa cac 451Pro Leu Arg Leu Ala His Arg Arg Val Asp Lys Gln Trp Phe Glu His

105 110 115atc acc agt gtg ttg aag att gat aat cgt atg cgc cat ttg cct ggg 499Ile Thr Ser Val Leu Lys Ile Asp Asn Arg Met Arg His Leu Pro Gly

120 125 130gag ctg tct ggc ggt cag caa caa cgc gcc gcg att gcc cgg gcg ttg 547Glu Leu Ser Gly Gly Gln GlnGln Arg Ala Ala Ile Ala Arg Ala Leu

135 140 145atg tct agg ccc gat att gtc att gcg gat gag cca aca gga agt ttg 595Met Ser Arg Pro Asp Ile Val Ile Ala Asp Glu Pro Thr Gly Ser Leu150 155 160 165gat tcc gtc acc agc gat gca gtg ttg aat ttg ttc cgc agc att gtt 643Asp Ser Val Thr Ser Asp Ala Val Leu Asn Leu Phe Arg Ser Ile Val

170 175 180gat gat ttt ggg cag tca ctt gtg ttt gtc acc cac gat aaa gat gct 691Asp Asp Phe Gly Gln Ser Leu Val Phe Val Thr His Asp Lys Asp Ala

185 190 195gct cac cgt ggt gac gtg ttg atc aca atg cgt gat ggc aag atc atc 739Ala His Arg Gly Asp Val Leu Ile Thr Met Arg Asp Gly Lys Ile Ile

200 205 210gat acg gca gat ttg cgg gtg ggg cgt taatgttcag gcttgctttc 786Asp Thr Ala Asp Leu Arg Val Gly Arg

215220 gct 789<210>298<211>222<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>298Met Met Ile Tyr Gly Lys Gly Ser Thr Glu Val Arg Ala Leu Asp Gly 151015 Ile Ser Val Gln Ile Gln Ser Asp Lys Trp Thr Ser Ile Met Gly Gln

20 25 30Ser Gly Ser Gly Lys Thr Thr Leu Leu Gln Cys Leu Ser Gly Leu Ala

35 40 45Gln Pro Thr Ser Gly Arg Val Thr Leu Asn Lys Asn Asn Ile Thr Leu

50 55 60Ser Ser Leu Ser Glu Asn Lys Arg Ala Lys Leu Arg Arg Thr His Ile 65 70 75 80Ser Met Val Phe Gln Asp Phe Asn Leu Val Pro Ile Leu Ser Val Lys

85 9095Asp Asn Ile Leu Leu Pro Leu Arg Leu Ala His Arg Arg Val Asp Lys

100 105 110Gln Trp Phe Glu His Ile Thr Ser Val Leu Lys Ile Asp Asn Arg Met

115 120 125Arg His Leu Pro Gly Glu Leu Ser Gly Gly Gln Gln Gln Arg Ala Ala

130 135 140Ile Ala Arg Ala Leu Met Ser Arg Pro Asp Ile Val Ile Ala Asp Glu145 150 155 160Pro Thr Gly Ser Leu Asp Ser Val Thr Ser Asp Ala Val Leu Asn Leu

165 170 175Phe Arg Ser Ile Val Asp Asp Phe Gly Gln Ser Leu Val Phe Val Thr

180 185 190His Asp Lys Asp Ala Ala His Arg Gly Asp Val Leu Ile Thr Met Arg

195 200 205Asp Gly Lys Ile Ile Asp Thr Ala Asp Leu Arg Val Gly Arg

210215220<210>299<211>789<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (766)<223>FRXA00410<400>299gtgttgatgc gttagtccac ccacgcagct acgccccaaa ggaataatct tgaaccctgc 60cacagataac gctccgccgg tcctttcagc ccaagatctc atg atg atc tat gga 115

Met Met Ile Tyr Gly

1 5aaa gga tca aca gaa gtt cgg gct ctc gat ggc att tct gta cag att 163Lys Gly Ser Thr Glu Val Arg Ala Leu Asp Gly Ile Ser Val Gln Ile

10 15 20cag tcc gac aaa tgg acc tcc atc atg ggg caa tca ggc tct ggc aaa 211Gln Ser Asp Lys Trp Thr Ser Ile Met Gly Gln Ser Gly Ser Gly Lys

25 30 35aca act ctg ttg cag tgc ctt tcc gga ttg gcg cag cca acc tca ggc 259Thr Thr Leu Leu Gln Cys Leu Ser Gly Leu Ala Gln Pro Thr Ser Gly

40 45 50aga gtg aca ctg aac aaa aac aac atc acg ttg agc tcc ctg tca gaa 307Arg Val Thr Leu Asn Lys Asn Asn Ile Thr Leu Ser Ser Leu Ser Glu

55 60 65aat aag cgt gcc aag ctg cgt cgc acg cac atc agc atg gtg ttt cag 355Asn Lys Arg Ala Lys Leu Arg Arg Thr His Ile Ser Met Val Phe Gln 70 75 80 85gat ttc aac ttg gtg cct att ttg tcg gtg aag gac aat att ttg ctg 403Asp Phe Asn Leu Val Pro Ile Leu Ser Val Lys Asp Asn Ile Leu Leu

90 95 100ccg ttg cgt ctt gcg cat cgc agg gtg gat aag cag tgg ttt gaa cac 451Pro Leu Arg Leu Ala His Arg Arg Val Asp Lys Gln Trp Phe Glu His

105 110 115atc acc agt gtg ttg aag att gat aat cgt atg cgc cat ttg cct ggg 499Ile Thr Ser Val Leu Lys Ile Asp Asn Arg Met Arg His Leu Pro Gly

120 125 130gag ctg tct ggc ggt cag caa caa cgc gcc gcg att gcc cgg gcg ttg 547Glu Leu Ser Gly Gly Gln Gln Gln Arg Ala Ala Ile Ala Arg Ala Leu

135 140 145atg tct agg ccc gat att gtc att gcg gat gag cca aca gga agt ttg 595Met Ser Arg Pro Asp Ile Val Ile Ala Asp Glu Pro Thr Gly Ser Leu150 155 160 165gat tcc gtc acc agc gat gca gtg ttg aat ttg ttc cgc agc att gtt 643Asp Ser Val Thr Ser Asp Ala Val Leu Asn Leu Phe Arg Ser Ile Val

170 175 l80gat gat ttt ggg cag tca ctt gtg ttt gtc acc cac gat aaa gat gct 691Asp Asp Phe Gly Gln Ser Leu Val Phe Val Thr His Asp Lys Asp Ala

185 190 195gct cac cgt ggt gac gtg ttg atc aca atg cgt gat ggc aag atc atc 739Ala His Arg Gly Asp Val Leu Ile Thr Met Arg Asp Gly Lys Ile Ile

200 205 210gat acg gca gat ttg cgg gtg ggg cgt taatgttcag gcttgctttc 786Asp Thr Ala Asp Leu Arg Val Gly Arg

215220 gct 789<210>300<211>222<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>300Met Met Ile Tyr Gly Lys Gly Ser Thr Glu Val Arg Ala Leu Asp Gly 151015 Ile Ser Val Gln Ile Gln Ser Asp Lys Trp Thr Ser Ile Met Gly Gln

20 25 30Ser Gly Ser Gly Lys Thr Thr Leu Leu Gln Cys Leu Ser Gly Leu Ala

35 40 45Gln Pro Thr Ser Gly Arg Val Thr Leu Asn Lys Asn Asn Ile Thr Leu

50 55 60Ser Ser Leu Ser Glu Asn Lys Arg Ala Lys Leu Arg Arg Thr His Ile 65 70 75 80Ser Met Val Phe Gln Asp Phe Asn Leu Val Pro Ile Leu Ser Val Lys

85 90 95Asp Asn Ile Leu Leu Pro Leu Arg Leu Ala His Arg Arg Val Asp Lys

100 105 110Gln Trp Phe Glu His Ile Thr Ser Val Leu Lys Ile Asp Asn Arg Met

115 120 125Arg His Leu Pro Gly Glu Leu Ser Gly Gly Gln Gln Gln Arg Ala Ala

130 135 140Ile Ala Arg Ala Leu Met Ser Arg Pro Asp Ile Val Ile Ala Asp Glu145 150 155 160Pro Thr Gly SerLeu Asp Ser Val Thr Ser Asp Ala Val Leu Asn Leu

165 170 175Phe Arg Ser Ile Val Asp Asp Phe Gly Gln Ser Leu Val Phe Val Thr

180 185 190His Asp Lys Asp Ala Ala His Arg Gly Asp Val Leu Ile Thr Met Arg

195 200 205Asp Gly Lys Ile Ile Asp Thr Ala Asp Leu Arg Val Gly Arg

210215220<210>301<211>1500<2l2>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101) }, (1477)<223>RXN00456<400>301ctcaccaacc cggagatcgt cacagcggtg ctaacggatc atgcctagct tatggcgtgc 60tcgtcgcaga cttttgctca ttgccctagg tgtacttggt gtg ctg cag gca ctg 115

Val Leu Gln Ala Leu

1 5ctg gcg atc atg gtg tcg ttg agc gta gcc gcc ata ctt gag gga aac 163Leu Ala Ile Met Val Ser Leu Ser Val Ala Ala Ile Leu Glu Gly Asn

10 15 20cga gca ctt gtt gga ttg ctg ctt gct acc acg ttg ggt ttg ggg gtg 211Arg Ala Leu Val Gly Leu Leu Leu Ala Thr Thr Leu Gly Leu Gly Val

25 30 35gcg cag tgg att caa aaa gta gtg gca gaa gat cta ggc cag cat tat 259Ala Gln Trp Ile Gln Lys Val Val Ala Glu Asp Leu Gly Gln His Tyr

40 45 50gtg cat gag gtg cgt cgt gaa ttg gtg ggt gct gcg ctg gtg cct gga 307Val His Glu Val Arg Arg Glu Leu Val Gly Ala Ala Leu Val Pro Gly

55 60 65aat acg gcc tcg ttg ggc gtg act gtc acc cga gcc agc aat gat ctc 355Asn Thr Ala Ser Leu Gly Val Thr ValThr Arg Ala Ser Asn Asp Leu 70 75 80 85acc gcg gtg cgc aat tgg gtg gct ttg ggc att gtt ccg atg gtc acc 403Thr Ala Val Arg Asn Trp Val Ala Leu Gly Ile Val Pro Met Val Thr

90 95 100ggg ctg ccg ttg att gcg att gtg ctg gtg gcg ttg ttt atc caa gat 451Gly Leu Pro Leu Ile Ala Ile Val Leu Val Ala Leu Phe Ile Gln Asp

105 110 115ctc cgc aca ggc gtg gct gtt act gtg cca ctg ctc atg tgt gta gcc 499Leu Arg Thr Gly Val Ala Val Thr Val Pro Leu Leu Met Cys Val Ala

120 125 130gtg ctg ccg gtg gtg gcg cgg tgg act ttg aaa aga gca cgt gaa cta 547Val Leu Pro Val Val Ala Arg Trp Thr Leu Lys Arg Ala Arg Glu Leu

135 140 145cgc aaa aaa cgt gga cgc atg gct gcg cgg atc gca gat tct gtc atg 595Arg Lys Lys Arg Gly Arg Met Ala Ala Arg I1e Ala Asp Ser Val Met150 155 160 165gct gga gaa tta ctg cac gca aca gga gca ata gac cgt gag ctc aat 643Ala Gly Glu Leu Leu His Ala Thr Gly Ala Ile Asp Arg Glu Leu Asn

170 175 180gca gtc acc cga gat tcc gac cga gtg gtg ata gct gct gta aga cgt 691Ala Val Thr Arg Asp Ser Asp Arg Val Val Ile Ala Ala Val Arg Arg

185 190 195tcc tgg gcc acc ggt ttt agc cgc gca ttg atg gcc atg gca gcc tcg 739Ser Trp Ala Thr Gly Phe Ser Arg Ala Leu Met Ala Met Ala Ala Ser

200 205 210ctt ggc act gtc agc att gtg att tct ggc cac ctg gaa gta agt gag 787Leu Gly Thr Val Ser Ile Val Ile Ser Gly His Leu Glu Val Ser Glu

215 220 225gtt gcg gga ata atg atg ctt ctt ggc gtt ctt gcc act cca gtt gca 835Val Ala Gly Ile Met Met Leu Leu Gly Val Leu Ala Thr Pro Val Ala230 235 240 245gaa ctt ggc cgc gtg gtg gaa tat cgc caa aat tat aaa gcc gcg aca 883Glu Leu Gly Arg Val Val Glu Tyr Arg Gln Asn Tyr Lys Ala Ala Thr

250 255 260cgc atc ctg att cca ctt ctg caa cga ggc tca gaa ttt aaa cac tcc 931Arg Ile Leu Ile Pro Leu Leu Gln Arg Gly Ser Glu Phe Lys His Ser

265 270 275caa caa aaa cta ccc ggg ttg caa gca aca gaa gga atc ccc ggt gtc 979Gln Gln Lys Leu Pro Gly Leu Gln Ala Thr Glu Gly Ile Pro Gly Val

280 285 290tat gtc aaa ggt att tcc gcc ctt cct gga gaa cgg atc tac ctc cac 1027Tyr Val Lys Gly Ile Ser Ala Leu Pro Gly Glu Arg Ile Tyr Leu His

295 300 305ggc tct gca gat gcg acg aga aaa tgg gtc acc tcg ttg tct gca atg 1075Gly Ser Ala Asp Ala Thr Arg Lys Trp Val Thr Ser Leu Ser Ala Met310 315 320 325gag gaa ggc aca gat gta ata gtc aac ggt caa agg ctt tcg cag ctt 1123Glu Glu Gly Thr Asp Val Ile Val Asn Gly Gln Arg Leu Ser Gln Leu

330 335 340cct ttg aaa caa cga cgc gcc ctc atc gga atc gcc tca gca cac cac 1171Pro Leu Lys Gln Arg Arg Ala Leu Ile Gly Ile Ala Ser Ala His His

345 350 355cac tta agc cgt ggt tca gta tcg cgc ctg gtt ggt ttg cga gtg ccg 1219His Leu Ser Arg Gly Ser Val Ser Arg Leu Val Gly Leu Arg Val Pro

360 365 370gat gcc acc gtg gaa gaa att gag caa gca ctg gaa caa gtt ggt ctg 1267Asp Ala Thr Val Glu Glu Ile Glu Gln Ala Leu Glu Gln Val Gly Leu

375 380 385aac aac acc ggg aaa caa cgc ttg aaa aac ggc gga cac ccc tgg agt 1315Asn Asn Thr Gly Lys Gln Arg Leu Lys Asn Gly Gly His Pro Trp Ser390 395 400 405act tcg cag atc aac aaa ctg aaa att gcc agc gcc acc ctt cga acc 1363Thr Ser Gln Ile Asn Lys Leu Lys Ile Ala Ser Ala Thr Leu Arg Thr

410 415 420cca ccg ctt ttg gta ctt gaa ggc atc acc cct gaa aac ctc ctc aac 1411Pro Pro Leu Leu Val Leu Glu Gly Ile Thr Pro Glu Asn Leu Leu Asn

425 430 435tat ccc gga gtg atc atc tcc acc gtt cag gag aac cca tcc gaa aca 1459Tyr Pro Gly Val Ile Ile Ser Thr Val Gln Glu Asn Pro Ser Glu Thr

440 445 450tgg cgg caa gtg aac atc taatctagaa acatggcagg acg 1500Trp Arg Gln Val Asn Ile

455<210>302<211>459<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>302Val Leu Gln Ala Leu Leu Ala Ile Met Val Ser Leu Ser Val Ala Ala 151015 Ile Leu Glu Gly Asn Arg Ala Leu Val Gly Leu Leu Leu Ala Thr Thr

20 25 30Leu Gly Leu Gly Val Ala Gln Trp Ile Gln Lys Val Val Ala Glu Asp

35 40 45Leu Gly Gln His Tyr Val His Glu Val Arg Arg Glu Leu Val Gly Ala

50 55 60Ala Leu Val Pro Gly Asn Thr Ala Ser Leu Gly Val Thr Val Thr Arg 65 70 75 80Ala Ser Asn Asp Leu Thr Ala Val Arg Asn Trp Val Ala Leu Gly Ile

85 90 95Val Pro Met Val Thr Gly Leu Pro Leu Ile Ala Ile Val Leu Val Ala

100 105 110Leu Phe Ile Gln Asp Leu Arg Thr Gly Val Ala Val Thr Val Pro Leu

115 120 125Leu Met Cys Val Ala Val Leu Pro Val Val Ala Arg Trp Thr Leu Lys

130 135 140Arg Ala Arg Glu Leu Arg Lys Lys Arg Gly Arg Met Ala Ala Arg Ile145 150 155 160Ala Asp Ser Val Met Ala Gly Glu Leu Leu His Ala Thr Gly Ala Ile

165 170 175Asp Arg Glu Leu Asn Ala Val Thr Arg Asp Ser Asp Arg Val Val Ile

180 185 190Ala Ala Val Arg Arg Ser Trp Ala Thr Gly Phe Ser Arg Ala Leu Met

195 200 205Ala Met Ala Ala Ser Leu Gly Thr Val Ser Ile Val Ile Ser Gly His

210 215 220Leu Glu Val Ser Glu Val Ala Gly Ile Met Met Leu Leu Gly Val Leu225 230 235 240Ala Thr Pro Val Ala Glu Leu Gly Arg Val Val Glu Tyr Arg Gln Asn

245 250 255Tyr Lys Ala Ala Thr Arg Ile Leu Ile Pro Leu Leu Gln Arg Gly Ser

260 265 270Glu Phe Lys His Ser Gln Gln Lys Leu Pro Gly Leu Gln Ala Thr Glu

275 280 285Gly Ile Pro Gly Val Tyr Val Lys Gly Ile Ser Ala Leu Pro Gly Glu

290 295 300Arg Ile Tyr Leu His Gly Ser Ala Asp Ala Thr Arg Lys Trp Val Thr305 310 315 320Ser Leu Ser Ala Met Glu Glu Gly Thr Asp Val Ile Val Asn GlyGln

325 330 335Arg Leu Ser Gln Leu Pro Leu Lys Gln Arg Arg Ala Leu Ile Gly Ile

340 345 350Ala Ser Ala His His His Leu Ser Arg Gly Ser Val Ser Arg Leu Val

355 360 365Gly Leu Arg Val Pro Asp Ala Thr Val Glu Glu Ile Glu Gln Ala Leu

370 375 380Glu Gln Val Gly Leu Asn Asn Thr Gly Lys Gln Arg Leu Lys Asn Gly385 390 395 400Gly His Pro Trp Ser Thr Ser Gln Ile Asn Lys Leu Lys Ile Ala Ser

405 410 415Ala Thr Leu Arg Thr Pro Pro Leu Leu Val Leu Glu Gly Ile Thr Pro

420 425 430Glu Asn Leu Leu Asn Tyr Pro Gly Val Ile Ile Ser Thr Val Gln Glu

435 440 445Asn Pro Ser Glu Thr Trp Arg Gln Val Asn Ile

450455<210>303<211>412<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (412)<223>FRXA00456<400>303ctcaccaacc cggagatcgt cacagcggtg ctaacggatc atgcctagct tatggcgtgc 60tcgtcgcaga cttttgctca ttgccctagg tgtacttggt gtg ctg cag gca ctg 115

Val Leu Gln Ala Leu

1 5ctg gcg atc atg gtg tcg ttg agc gta gcc gcc ata ctt gag gga aac 163Leu Ala Ile Met Val Ser Leu Ser Val Ala Ala Ile Leu Glu Gly Asn

10 15 20cga gca ctt gtt gga ttg ctg ctt gct acc acg ttg ggt ttg ggg gtg 211Arg Ala LeuVal Gly Leu Leu Leu Ala Thr Thr Leu Gly Leu Gly Val

25 30 35gcg cag tgg att caa aaa gta gtg gca gaa gat cta ggc cag cat tat 259Ala Gln Trp Ile Gln Lys Val Val Ala Glu Asp Leu Gly Gln His Tyr

40 45 50gtg cat gag gtg cgt cgt gaa ttg gtg ggt gct gcg ctg gtg cct gga 307Val His Glu Val Arg Arg Glu Leu Val Gly Ala Ala Leu Val Pro Gly

55 60 65aat acg gcc tcg ttg ggc gtg act gtc acc cga gcc agc aat gat ctc 355Asn Thr Ala Ser Leu Gly Val Thr Val Thr Arg Ala Ser Asn Asp Leu 70 75 80 85acc gcg gtg cgc aat tgg gtg gct ttg ggc att gtt ccg atg gtc acc 403Thr Ala Val Arg Asn Trp Val Ala Leu Gly Ile Val Pro Met Val Thr

9095100 ggg ctg ccg 412Gly Leu Pro<210>304<211>104<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>304Val Leu Gln Ala Leu Leu Ala Ile Met Val Ser Leu Ser Val Ala Ala 151015 Ile Leu Glu Gly Asn Arg Ala Leu Val Gly Leu Leu Leu Ala Thr Thr

20 25 30Leu Gly Leu Gly Val Ala Gln Trp Ile Gln Lys Val Val Ala Glu Asp

35 40 45Leu Gly Gln His Tyr Val His Glu Val Arg Arg Glu Leu Val Gly Ala

50 55 60Ala Leu Val Pro Gly Asn Thr Ala Ser Leu Gly Val Thr Val Thr Arg 65 70 75 80Ala Ser Asn Asp Leu Thr Ala Val Arg Asn Trp Val Ala Leu Gly Ile

85 90 95Val Pro Met Val Thr Gly Leu Pro

100<210>305<211>1040<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(31). (1017)<223>FRXA00459<400>305aggcgtggct gttactgtgc cactgctcat gtg tgt acc cgt gct gcc ggt ggt 54

Val Cys Thr Arg Ala Ala Gly Gly

1 5ggc gcg gtg act ttg aaa aga gca cgt gaa cta cgc aaa aaa cgt gga 102Gly Ala Val Thr Leu Lys Arg Ala Arg Glu Leu Arg Lys Lys Arg Gly

10 15 20cgc atg gct gcg cgg atc gca gat tct gtc atg gct gga gaa tta ctg 150Arg Met Ala Ala Arg Ile Ala Asp Ser Val Met Ala Gly Glu Leu Leu 25 30 35 40cac gca aca gga gca ata gac cgt gag ctc aat gca gtc acc cga gat 198His Ala Thr Gly Ala Ile Asp Arg Glu Leu Asn Ala Val Thr Arg Asp

45 50 55tcc gac cga gtg gtg ata gct gct gta aga cgt tcc tgg gcc acc ggt 246Ser Asp Arg Val Val Ile Ala Ala Val Arg Arg Ser Trp Ala Thr Gly

60 65 70ttt agc cgc gca ttg atg gcc atg gca gcc tcg ctt ggc act gtc agc 294Phe Ser Arg Ala Leu Met Ala Met Ala Ala Ser Leu Gly Thr Val Ser

75 80 85att gtg att tct ggc cac ctg gaa gta agt gag gtt gcg gga ata atg 342Ile Val Ile Ser Gly His Leu Glu Val Ser Glu Val Ala Gly Ile Met

90 95 100atg ctt ctt ggc gtt ctt gcc act cca gtt gca gaa ctt ggc cgc gtg 390Met Leu Leu Gly Val Leu Ala Thr Pro Val Ala Glu Leu Gly Arg Val105 110 115 120gtg gaa tat cgc caa aat tat aaa gcc gcg aca cgc atc ctg att cca 438Val Glu Tyr Arg Gln Asn Tyr Lys Ala Ala Thr Arg Ile Leu Ile Pro

125 130 135ctt ctg caa cga ggc tca gaa ttt aaa cac tcc caa caa aaa cta ccc 486Leu Leu Gln Arg Gly Ser Glu Phe Lys His Ser Gln Gln Lys Leu Pro

140 145 150ggg ttg caa gca aca gaa gga atc ccc ggt gtc tat gtc aaa ggt att 534Gly Leu Gln Ala Thr Glu Gly Ile Pro Gly Val Tyr Val Lys Gly Ile

155 160 165tcc gcc ctt cct gga gaa cgg atc tac ctc cac ggc tct gca gat gcg 582Ser Ala Leu Pro Gly Glu Arg Ile Tyr Leu His Gly Ser Ala Asp Ala

170 175 180acg aga aaa tgg gtc acc tcg ttg tct gca atg gag gaa ggc aca gat 630Thr Arg Lys Trp Val Thr Ser Leu Ser Ala Met Glu Glu Gly Thr Asp185 190 195 200gta ata gtc aac ggt caa agg ctt tcg cag ctt cct ttg aaa caa cga 678Val Ile Val Asn Gly Gln Arg Leu Ser Gln Leu Pro Leu Lys Gln Arg

205 210 215cgc gcc ctc atc gga atc gcc tca gca cac cac cac tta agc cgt ggt 726Arg Ala Leu Ile Gly Ile Ala Ser Ala His His His Leu Ser Arg Gly

220 225 230tca gta tcg cgc ctg gtt ggt ttg cga gtg ccg gat gcc acc gtg gaa 774Ser Val Ser Arg Leu Val Gly Leu Arg Val Pro Asp Ala Thr Val Glu

235 240 245gaa att gag caa gca ctg gaa caa gtt ggt ctg aac aac acc ggg aaa 822Glu Ile Glu Gln Ala Leu Glu Gln Val Gly Leu Asn Asn Thr Gly Lys

250 255 260caa cgc ttg aaa aac ggc gga cac ccc tgg agt act tcg cag atc aac 870Gln Arg Leu Lys Asn Gly Gly His Pro Trp Ser Thr Ser Gln Ile Asn265 270 275 280aaa ctg aaa att gcc agc gcc acc ctt cga acc cca ccg ctt ttg gta 918Lys Leu Lys Ile Ala Ser Ala Thr LeuArg Thr Pro Pro Leu Leu Val

285 290 295ctt gaa ggc atc acc cct gaa aac ctc ctc aac tat ccc gga gtg atc 966Leu Glu Gly Ile Thr Pro Glu Asn Leu Leu Asn Tyr Pro Gly Val Ile

300 305 310atc tcc acc gtt cag gag aac cca tcc gaa aca tgg cgg caa gtg aac 1014Ile Ser Thr Val Gln Glu Asn Pro Ser Glu Thr Trp Arg Gln Val Asn

315320325 atc taatctagaa acatggcagg acg 1040Ile<210>306<211>329<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>306Val Cys Thr Arg Ala Ala Gly Gly Gly Ala Val Thr Leu Lys Arg Ala 151015 Arg Glu Leu Arg Lys Lys Arg Gly Arg Met Ala Ala Arg Ile Ala Asp

20 25 30Ser Val Met Ala Gly Glu Leu Leu His Ala Thr Gly Ala Ile Asp Arg

35 40 45Glu Leu Asn Ala Val Thr Arg Asp Ser Asp Arg Val Val Ile Ala Ala

50 55 60Val Arg Arg Ser Trp Ala Thr Gly Phe Ser Arg Ala Leu Met Ala Met 65 70 75 80Ala Ala Ser Leu Gly Thr Val Ser Ile Val Ile Ser Gly His Leu Glu

85 90 95Val Ser Glu Val Ala Gly Ile Met Met Leu Leu Gly Val Leu Ala Thr

100 105 110Pro Val Ala Glu Leu Gly Arg Val Val Glu Tyr Arg Gln Asn Tyr Lys

115 120 125Ala Ala Thr Arg Ile Leu Ile Pro Leu Leu Gln Arg Gly Ser Glu Phe

130 135 140Lys His Ser Gln Gln Lys Leu Pro Gly Leu Gln Ala Thr Glu Gly Ile145 150 155160Pro Gly Val Tyr Val Lys Gly Ile Ser Ala Leu Pro Gly Glu Arg Ile

165 170 175Tyr Leu His Gly Ser Ala Asp Ala Thr Arg Lys Trp Val Thr Ser Leu

180 185 190Ser Ala Met Glu Glu Gly Thr Asp Val Ile Val Asn Gly Gln Arg Leu

195 200 205Ser Gln Leu Pro Leu Lys Gln Arg Arg Ala Leu Ile Gly Ile Ala Ser

210 215 220Ala His His His Leu Ser Arg Gly Ser Val Ser Arg Leu Val Gly Leu225 230 235 240Arg Val Pro Asp Ala Thr Val Glu Glu Ile Glu Gln Ala Leu Glu Gln

245 250 255Val Gly Leu Asn Asn Thr Gly Lys Gln Arg Leu Lys Asn Gly Gly His

260 265 270Pro Trp Ser Thr Ser Gln Ile Asn Lys Leu Lys Ile Ala Ser Ala Thr

275 280 285Leu Arg Thr Pro Pro Leu Leu Val Leu Glu Gly Ile Thr Pro Glu Asn

290 295 300Leu Leu Asn Tyr Pro Gly Val Ile Ile Ser Thr Val Gln Glu Asn Pro305 310 315 320Ser Glu Thr Trp Arg Gln Val Asn Ile

325<210>307<211>771<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). - (748)<223>RXN01604<400>307ctctcatgtt gttgtcctct agttgacagc gggggtggtg gtggtcctaa aatagcctac 60gataactgat agtgtttcct ccacttacgg aagaagatac atg aat acc cct ctt 115

Met Asn Thr Pro Leu

1 5ttg aga agc tct ggg ctc tcc atc cgc gac aca ccc ttc gcc gat gtt 163Leu Arg Ser Ser Gly Leu Ser Ile Arg Asp Thr Pro Phe Ala Asp Val

10 15 20gag ata gct cca gac agc gga ctc act ttg ctg agc acc ggg cgc gaa 211Glu Ile Ala Pro Asp Ser Gly Leu Thr Leu Leu Ser Thr Gly Arg Glu

25 30 35tcc caa tcc agt tcc ttt tct ttg gta ctt tcc ggc cgc atg cgc gcc 259Ser Gln Ser Ser Ser Phe Ser Leu Val Leu Ser Gly Arg Met Arg Ala

40 45 50tcc acc gga acc atc gaa tta aac ggc gaa ccc atc aag gca acc aag 307Ser Thr Gly Thr Ile Glu Leu Asn Gly Glu Pro Ile Lys Ala Thr Lys

55 60 65ctg gcc aag cat gtg gct ttg gcg ggc atc cct gaa atc gat tca ctc 355Leu Ala Lys His Val Ala Leu Ala Gly Ile Pro Glu Ile Asp Ser Leu 70 75 80 85gag cga ctt gtc act gtg cgc acc gtt gtc cgt gaa caa ctc gcc tgg 403Glu Arg Leu Val Thr Val Arg Thr Val Val Arg Glu Gln Leu Ala Trp

90 95 100tca agc cct tgg tac ctg atg gtg ccc agg gat att agt gat tcg gga 451Ser Ser Pro Trp Tyr Leu Met Val Pro Arg Asp Ile Ser Asp Ser Gly

105 110 115cgg tgg gtt gac gtc gaa aag cat ctt ggc ctg aac ctg aac cct aaa 499Arg Trp Val Asp Val Glu Lys His Leu Gly Leu Asn Leu Asn Pro Lys

120 125 130acc tta atc ggc gac ctc agc gtg ctc gag cgt ttt aag ctg cgc atc 547Thr Leu Ile Gly Asp Leu Ser Val Leu Glu Arg Phe Lys Leu Arg Ile

135 140 145gcg ctg gcg ctg ctg gcg cgg cca gag gcg caa ctg ttggtc gtg gat 595Ala Leu Ala Leu Leu Ala Arg Pro Glu Ala Gln Leu Leu Val Val Asp150 155 160 165gat ccc gat caa gtg cgc agc atg gaa ttg cgt gcg gag gtg ttg cac 643Asp Pro Asp Gln Val Arg Ser Met Glu Leu Arg Ala Glu Val Leu His

170 175 180gca ttg aaa ggc gtt gca gag gat ctc cct gtg gtc gtg gta tcc acc 691Ala Leu Lys Gly Val Ala Glu Asp Leu Pro Val Val Val Val Ser Thr

185 190 195aac cca gat ttt gat tcc ttg gcc gat acc gct ttg acc att acg ggg 739Asn Pro Asp Phe Asp Ser Leu Ala Asp Thr Ala Leu Thr Ile Thr Gly

200 205 210gct gga aac taatggcatt tttacacttt ggc 771Ala Gly Asn

215<210>308<211>216<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>308Met Asn Thr Pro Leu Leu Arg Ser Ser Gly Leu Ser Ile Arg Asp Thr 151015 Pro Phe Ala Asp Val Glu Ile Ala Pro Asp Ser Gly Leu Thr Leu Leu

20 25 30Ser Thr Gly Arg Glu Ser Gln Ser Ser Ser Phe Ser Leu Val Leu Ser

35 40 45Gly Arg Met Arg Ala Ser Thr Gly Thr Ile Glu Leu Asn Gly Glu Pro

50 55 60Ile Lys Ala Thr Lys Leu Ala Lys His Val Ala Leu Ala Gly Ile Pro 65 70 75 80Glu Ile Asp Ser Leu Glu Arg Leu Val Thr Val Arg Thr Val Val Arg

85 90 95Glu Gln Leu Ala Trp Ser Ser Pro Trp Tyr Leu Met Val Pro Arg Asp

100 105 110Ile Ser Asp Ser Gly Arg Trp Val Asp ValGlu Lys His Leu Gly Leu

115 120 125Asn Leu Asn Pro Lys Thr Leu Ile Gly Asp Leu Ser Val Leu Glu Arg

130 135 140Phe Lys Leu Arg Ile Ala Leu Ala Leu Leu Ala Arg Pro Glu Ala Gln145 150 155 160Leu Leu Val Val Asp Asp Pro Asp Gln Val Arg Ser Met Glu Leu Arg

165 170 175Ala Glu Val Leu His Ala Leu Lys Gly Val Ala Glu Asp Leu Pro Val

180 185 190Val Val Val Ser Thr Asn Pro Asp Phe Asp Ser Leu Ala Asp Thr Ala

195 200 205Leu Thr Ile Thr Gly Ala Gly Asn

210215<210>309<211>629<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (606)<223>FRXA01604<400>309gac aca ccc ttc gcc gat gtt gag ata gct cca gac agc gga ctc act 48Asp Thr Pro Phe Ala Asp Val Glu Ile Ala Pro Asp Ser Gly Leu Thr 151015 ttg ctg agc acc ggg cgc gaa tcc caa tcc agt tcc ttt tct ttg gta 96Leu Leu Ser Thr Gly Arg Glu Ser Gln Ser Ser Ser Phe Ser Leu Val

20 25 30ctt tcc ggc cgc atg cgc gcc tcc acc gga acc atc gaa tta aac ggc 144Leu Ser Gly Arg Met Arg Ala Ser Thr Gly Thr Ile Glu Leu Asn Gly

35 40 45gaa ccc atc aag gca acc aag ctg gcc aag cat gtg gct ttg gcg ggc 192Glu Pro Ile Lys Ala Thr Lys Leu Ala Lys His Val Ala Leu Ala Gly

50 55 60atc cct gaa atc gat tca ctc gag cga ctt gtc act gtg cgc acc gtt 240Ile Pro Glu Ile Asp Ser Leu Glu Arg Leu Val Thr Val Arg Thr Val 6570 75 80gtc cgt gaa caa ctc gcc tgg tca agc cct tgg tac ctg atg gtg ccc 288Val Arg Glu Gln Leu Ala Trp Ser Ser Pro Trp Tyr Leu Met Val Pro

85 90 95agg gat att agt gat tcg gga cgg tgg gtt gac gtc gaa aag cat ctt 336Arg Asp Ile Ser Asp Ser Gly Arg Trp Val Asp Val Glu Lys His Leu

100 105 110ggc ctg aac ctg aac cct aaa acc tta atc ggc gac ctc agc gtg ctc 384Gly Leu Asn Leu Asn Pro Lys Thr Leu Ile Gly Asp Leu Ser Val Leu

115 120 125gag cgt ttt aag ctg cgc atc gcg ctg gcg ctg ctg gcg cgg cca gag 432Glu Arg Phe Lys Leu Arg Ile Ala Leu Ala Leu Leu Ala Arg Pro Glu

130 135 140gcg caa ctg ttg gtc gtg gat gat ccc gat caa gtg cgc agc atg gaa 480Ala Gln Leu Leu Val Val Asp Asp Pro Asp Gln Val Arg Ser Met Glu145 150 155 160ttg cgt gcg gag gtg ttg cac gca ttg aaa ggc gtt gca gag gat ctc 528Leu Arg Ala Glu Val Leu His Ala Leu Lys Gly Val Ala Glu Asp Leu

165 170 175cct gtg gtc gtg gta tcc acc aac cca gat ttt gat tcc ttg gcc gat 576Pro Val Val Val Val Ser Thr Asn Pro Asp Phe Asp Ser Leu Ala Asp

180 185 190acc gct ttg acc att acg ggg gct gga aac taatggcatt tttacacttt 626Thr Ala Leu Thr Ile Thr Gly Ala Gly Asn

195200 ggc 629<210>310<211>202<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>310Asp Thr Pro Phe Ala Asp Val Glu Ile Ala Pro Asp Ser Gly Leu Thr 151015 Leu Leu Ser Thr Gly Arg Glu Ser Gln Ser Ser Ser Phe Ser Leu Val

2025 30Leu Ser Gly Arg Met Arg Ala Ser Thr Gly Thr Ile Glu Leu Asn Gly

35 40 45Glu Pro Ile Lys Ala Thr Lys Leu Ala Lys His Val Ala Leu Ala Gly

50 55 60Ile Pro Glu Ile Asp Ser Leu Glu Arg Leu Val Thr Val Arg Thr Val 65 70 75 80Val Arg Glu Gln Leu Ala Trp Ser Ser Pro Trp Tyr Leu Met Val Pro

85 90 95Arg Asp Ile Ser Asp Ser Gly Arg Trp Val Asp Val Glu Lys His Leu

100 105 110Gly Leu Asn Leu Asn Pro Lys Thr Leu Ile Gly Asp Leu Ser Val Leu

115 120 125Glu Arg Phe Lys Leu Arg Ile Ala Leu Ala Leu Leu Ala Arg Pro Glu

130 135 140Ala Gln Leu Leu Val Val Asp Asp Pro Asp Gln Val Arg Ser Met Glu145 150 155 160Leu Arg Ala Glu Val Leu His Ala Leu Lys Gly Val Ala Glu Asp Leu

165 170 175Pro Val Val Val Val Ser Thr Asn Pro Asp Phe Asp Ser Leu Ala Asp

180 185 190Thr Ala Leu Thr Ile Thr Gly Ala Gly Asn

195200<210>311<211>2262<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (2239)<223>RXN02547<400>311ggggccgtcg ataagcgaag aacaattagc actgcgcgcg ctggtctgac gcattggtta 60aggggctggc ggtccggcgc cggaatcggc ggaggagctt ttg gag ctc aac aac 115

Leu Glu Leu Asn Asn

1 5gct gcg cgg ctg acc gtg gat gag tat ccg gcg gcg agg gaa gcg ctt 163Ala Ala Arg Leu Thr Val Asp Glu Tyr Pro Ala Ala Arg Glu Ala Leu

10 15 20gaa tct gca ggt cag agg aat gta gag gac cga acc cgt gcg gtt gat 211Glu Ser Ala Gly Gln Arg Asn Val Glu Asp Arg Thr Arg Ala Val Asp

25 30 35gag ttc aaa gcg gcg gat caa gag ctg tct tct ttg agt aaa ggc agc 259Glu Phe Lys Ala Ala Asp Gln Glu Leu Ser Ser Leu Ser Lys Gly Ser

40 45 50agt aat att gag tac cgt ttg ctg cag gtg cgg gaa aat ttg tgt cag 307Ser Asn Ile Glu Tyr Arg Leu Leu Gln Val Arg Glu Asn Leu Cys Gln

55 60 65gat ttg ggc gtg agc ccg cgg gat atg ccc ttt gcc ggt gag ctg att 355Asp Leu Gly Val Ser Pro Arg Asp Met Pro Phe Ala Gly Glu Leu Ile 70 75 80 85gat ccg aat aat gcg gaa tgg gaa ccc gtt gtg cag cgc att ttg ggt 403Asp Pro Asn Asn Ala Glu Trp Glu Pro Val Val Gln Arg Ile Leu Gly

90 95 100ggt ttt gct gcg gaa atg ttg gtt cct cat ggg ttg ttg cca cgg gtt 451Gly Phe Ala Ala Glu Met Leu Val Pro His Gly Leu Leu Pro Arg Val

105 110 115cgg gat tgg gta aat gcc aaa cat ttg gca gcg ctg ctg aaa ttc aac 499Arg Asp Trp Val Asn Ala Lys His Leu Ala Ala Leu Leu Lys Phe Asn

120 125 130ggc gtg gtg aca acg ggg gag tac aaa acc tcg cgt ttt ccg gcg gat 547Gly Val Val Thr Thr Gly Glu Tyr Lys Thr Ser Arg Phe Pro Ala Asp

135 140 145tcc ctg atc cga aaa gtt gat gtt gtg gag tcg ccg ttt cgc gat tgg 595Ser Leu Ile Arg Lys Val Asp Val Val Glu Ser Pro Phe Arg Asp Trp150 155 160 165gta aat caa gaa tta ggc aag cgt ttt aat att cgg tgc gtg cgc act 643Val Asn Gln Glu Leu Gly Lys Arg Phe Asn Ile Arg Cys Val Arg Thr

170 175 180cct gag gaa ttg tcg gcg ctg ggg cca cgc gat cag ggc gtg acc att 691Pro Glu Glu Leu Ser Ala Leu Gly Pro Arg Asp Gln Gly Val Thr Ile

185 190 195ttg ggt gtg cga aaa ttt gcg cag cag aca ggc gat ccg acg acg cgt 739Leu Gly Val Arg Lys Phe Ala Gln Gln Thr Gly Asp Pro Thr Thr Arg

200 205 210tgg gaa aaa gat gat cgc cga aag ctg ggg gat cgt tcc aca tac cgt 787Trp Glu Lys Asp Asp Arg Arg Lys Leu Gly Asp Arg Ser Thr Tyr Arg

215 220 225ttg ggt tcc acc aat gat gcc aag gtg gaa acg ctt cgg gaa acc gtg 835Leu Gly Ser Thr Asn Asp Ala Lys Val Glu Thr Leu Arg Glu Thr Val230 235 240 245aaa gct ggc aaa gca gtt gtg cag gca gct gat aat cgc att gct gca 883Lys Ala Gly Lys Ala Val Val Gln Ala Ala Asp Asn Arg Ile Ala Ala

250 255 260aac cgc gct gag ctg cgg gaa ctt gaa cgg cag tat caa gct tcg caa 931Asn Arg Ala Glu Leu Arg Glu Leu Glu Arg Gln Tyr Gln Ala Ser Gln

265 270 275gaa att ttg aaa gtg tcg tgg gct cag att gat gtg gaa tca gcc gac 979Glu Ile Leu Lys Val Ser Trp Ala Gln Ile Asp Val Glu Ser Ala Asp

280 285 290gcg gcg att gct gag ctg gac cga ttg ctg gaa gag ctg aac aac act 1027Ala Ala Ile Ala Glu Leu Asp Arg Leu Leu Glu Glu Leu Asn Asn Thr

295 300 305cca gag gcc acc gag ctt tcc gcg cgg cat gag gcg gcg aag cag acg 1075Pro Glu Ala Thr Glu Leu Ser Ala Arg His Glu Ala Ala Lys Gln Thr310 315 320 325ctc gcg agg gtt tct gac ttg ctt gtc gca gct cag agt gag gaa acc 1123Leu Ala Arg Val Ser Asp Leu Leu Val Ala Ala Gln Ser Glu Glu Thr

330 335 340gtg gcg tcg atg aac ctg aaa cgc gcc gaa act gaa ttg aaa cgg ctc 1171Val Ala Ser Met Asn Leu Lys Arg Ala Glu Thr Glu Leu Lys Arg Leu

345 350 355gaa agc ctg ccg gtt gcg gag gtt tct gaa gaa atc gcg cgg gaa gtg 1219Glu Ser Leu Pro Val Ala Glu Val Ser Glu Glu Ile Ala Arg Glu Val

360 365 370gag aaa cta ttt ctt gcc aac acc cgc cgg gtt cac gcc gcc aac gtg 1267Glu Lys Leu Phe Leu Ala Asn Thr Arg Arg Val His Ala Ala Asn Val

375 380 385gat gag cag acc att gcg ctg cgc gag gat ctg gac aaa caa atc gat 1315Asp Glu Gln Thr Ile Ala Leu Arg Glu Asp Leu Asp Lys Gln Ile Asp390 395 400 405gcc aat gag gca gaa ctt cga cgt tgt gaa aac caa att gtt ggc att 1363Ala Asn Glu Ala Glu Leu Arg Arg Cys Glu Asn Gln Ile Val Gly Ile

410 415 420ttg cgc agc tat att gaa acg tgg cct gcg aac cgc gct gac tta caa 1411Leu Arg Ser Tyr Ile Glu Thr Trp Pro Ala Asn Arg Ala Asp Leu Gln

425 430 435gcc gaa cct gag ttt gtt ggt gag gcc atc aac cgc ctc ggc gag ctt 1459Ala Glu Pro Glu Phe Val Gly Glu Ala Ile Asn Arg Leu Gly Glu Leu

440 445 450cgc agc gat cgt ttg gca gaa ttc acg gcc aaa ttc cta ggg ctc atg 1507Arg Ser Asp Arg Leu Ala Glu Phe Thr Ala Lys Phe Leu Gly Leu Met

455 460 465aac gag atg tcc acc cga aac ctc ggc caa atc tcg cgg cgt cta cgt 1555Asn Glu Met Ser Thr Arg Ash Leu Gly Gln Ile Ser Arg Arg Leu Arg470 475 480 485gat gcg cgc cgg gaa atc gag gag cgc atc gag ccg atc aac gcc tcc 1603Asp Ala Arg Arg Glu Ile Glu Glu Arg Ile Glu Pro Ile Asn Ala Ser

490 495 500ttg gcg cag tcg gaa ttc aac gaa ggt cgc ttc ctg cac atc gac atc 1651Leu Ala Gln Ser Glu Phe Asn Glu Gly Arg Phe Leu His Ile Asp Ile

505 510 515cgt gat caa agt ggt ccg att gtg agg gaa ttc cag cag aaa ctt gat 1699Arg Asp Gln Ser Gly Pro Ile Val Arg Glu Phe Gln Gln Lys Leu Asp

520 525 530gcc gct acc agc ggt gac ctg gga acc agt acc gag aaa caa gcc ttc 1747Ala Ala Thr Ser Gly Asp Leu Gly Thr Ser Thr Glu Lys Gln Ala Phe

535 540 545gcc cgt tat gcg ctg atc gct gaa atc att tcc aaa ctc gcc tcc cac 1795Ala Arg Tyr Ala Leu Ile Ala Glu Ile Ile Ser Lys Leu Ala Ser His550 555 560 565gac tcc gcc gac gcc cgc tgg cgc aac acc gtt cta gac acc cgc cgc 1843Asp Ser Ala Asp Ala Arg Trp Arg Asn Thr Val Leu Asp Thr Arg Arg

570 575 580cac gtt cgc ttc atc ggc ctc gag cgc gat tcc gac ggc gca acc gtc 1891His Val Arg Phe Ile Gly Leu Glu Arg Asp Ser Asp Gly Ala Thr Val

585 590 595aac acc tac gtc gac tcc gca tca ctt tca ggc gga caa gcc cag aag 1939Asn Thr Tyr Val Asp Ser Ala Ser Leu Ser Gly Gly Gln Ala Gln Lys

600605 610ctg gtg ttt ttc tgc ctc gcc gct gcc ttg cgc tac cag cta gcc gaa 1987Leu Val Phe Phe Cys Leu Ala Ala Ala Leu Arg Tyr Gln Leu Ala Glu

615 620 625ccc ggc gcc cat tat ccc acc tac gcc acc gtc att ctg gac gaa gcc 2035Pro Gly Ala His Tyr Pro Thr Tyr Ala Thr Val Ile Leu Asp Glu Ala630 635 640 645ttc gac cgc gcc gac ccc gcc ttc acc cgc caa acc atg aac gtc ttc 2083Phe Asp Arg Ala Asp Pro Ala Phe Thr Arg Gln Thr Met Asn Val Phe

650 655 660cac agc ttc ggc ttc cac atg gtg ctc gcg acc ccg ctg aaa ctt atc 2131His Ser Phe Gly Phe His Met Val Leu Ala Thr Pro Leu Lys Leu Ile

665 670 675caa acc ctc ggc gat tat gtc ggc tcc acc atc gtg gtc agc tac acc 2179Gln Thr Leu Gly Asp Tyr Val Gly Ser Thr Ile Val Val Ser Tyr Thr

680 685 690gaa aaa cca aac gcc cag ggc gca att cag ggc aat tcc agt ttc tct 2227Glu Lys Pro Asn Ala Gln Gly Ala Ile Gln Gly Asn Ser Ser Phe Ser

695700705 agg atc gag aaa taacatgcca ttgtttatcg acg 2262Arg Ile Glu Lys710<210>312<211>713<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>312Leu Glu Leu Asn Asn Ala Ala Arg Leu Thr Val Asp Glu Tyr Pro Ala 151015 Ala Arg Glu Ala Leu Glu Ser Ala Gly Gln Arg Asn Val Glu Asp Arg

20 25 30Thr Arg Ala Val Asp Glu Phe Lys Ala Ala Asp Gln Glu Leu Ser Ser

35 40 45Leu Ser Lys Gly Ser Ser Asn Ile Glu Tyr Arg Leu Leu Gln Val Arg

50 55 60Glu Asn Leu Cys Gln Asp Leu Gly Val Ser Pro Arg Asp Met Pro Phe 65 70 75 80Ala Gly Glu Leu Ile Asp Pro Asn Asn Ala Glu Trp Glu Pro Val Val

85 90 95Gln Arg Ile Leu Gly Gly Phe Ala Ala Glu Met Leu Val Pro His Gly

100 105 110Leu Leu Pro Arg Val Arg Asp Trp Val Asn Ala Lys His Leu Ala Ala

115 120 125Leu Leu Lys Phe Asn Gly Val Val Thr Thr Gly Glu Tyr Lys Thr Ser

130 135 140Arg Phe Pro Ala Asp Ser Leu Ile Arg Lys Val Asp Val Val Glu Ser145 150 155 160Pro Phe Arg Asp Trp Val Asn Gln Glu Leu Gly Lys Arg Phe Asn Ile

165 170 175Arg Cys Val Arg Thr Pro Glu Glu Leu Ser Ala Leu Gly Pro Arg Asp

180 185 190Gln Gly Val Thr Ile Leu Gly Val Arg Lys Phe Ala Gln Gln Thr Gly

195 200 205Asp Pro Thr Thr Arg Trp Glu Lys Asp Asp Arg Arg Lys Leu Gly Asp

210 215 220Arg Ser Thr Tyr Arg Leu Gly Ser Thr Asn Asp Ala Lys Val Glu Thr225 230 235 240Leu Arg Glu Thr Val Lys Ala Gly Lys Ala Val Val Gln Ala Ala Asp

245 250 255Asn Arg Ile Ala Ala Asn Arg Ala Glu Leu Arg Glu Leu Glu Arg Gln

260 265 270Tyr Gln Ala Ser Gln Glu Ile Leu Lys Val Ser Trp Ala Gln Ile Asp

275 280 285Val Glu Ser Ala Asp Ala Ala Ile Ala Glu Leu AspArg Leu Leu Glu

290 295 300Glu Leu Asn Asn Thr Pro Glu Ala Thr Glu Leu Ser Ala Arg His Glu305 310 315 320Ala Ala Lys Gln Thr Leu Ala Arg Val Ser Asp Leu Leu Val Ala Ala

325 330 335Gln Ser Glu Glu Thr Val Ala Ser Met Asn Leu Lys Arg Ala Glu Thr

340 345 350Glu Leu Lys Arg Leu Glu Ser Leu Pro Val Ala Glu Val Ser Glu Glu

355 360 365Ile Ala Arg Glu Val Glu Lys Leu Phe Leu Ala Asn Thr Arg Arg Val

370 375 380His Ala Ala Asn Val Asp Glu Gln Thr Ile Ala Leu Arg Glu Asp Leu385 390 395 400Asp Lys Gln Ile Asp Ala Asn Glu Ala Glu Leu Arg Arg Cys Glu Asn

405 410 415Gln Ile Val Gly Ile Leu Arg Ser Tyr Ile Glu Thr Trp Pro Ala Asn

420 425 430Arg Ala Asp Leu Gln Ala Glu Pro Glu Phe Val Gly Glu Ala Ile Asn

435 440 445Arg Leu Gly Glu Leu Arg Ser Asp Arg Leu Ala Glu Phe Thr Ala Lys

450 455 460Phe Leu Gly Leu Met Asn Glu Met Ser Thr Arg Asn Leu Gly Gln Ile465 470 475 480Ser Arg Arg Leu Arg Asp Ala Arg Arg Glu Ile Glu Glu Arg Ile Glu

485 490 495Pro Ile Asn Ala Ser Leu Ala Gln Ser Glu Phe Asn Glu Gly Arg Phe

500 505 510Leu His Ile Asp Ile Arg Asp Gln Ser Gly Pro Ile Val Arg Glu Phe

515 520 525Gln Gln Lys Leu Asp Ala Ala Thr Ser Gly Asp Leu Gly Thr Ser Thr

530 535 540Glu Lys Gln Ala Phe Ala Arg Tyr Ala Leu Ile Ala Glu Ile Ile Ser545 550 555 560Lys Leu Ala Ser His Asp Ser Ala Asp Ala Arg Trp Arg Asn Thr Val

565 570 575Leu Asp Thr Arg Arg His Val Arg Phe Ile Gly Leu Glu Arg Asp Ser

580 585 590Asp Gly Ala Thr Val Asn Thr Tyr Val Asp Ser Ala Ser Leu Ser Gly

595 600 605Gly Gln Ala Gln Lys Leu Val Phe Phe Cys Leu Ala Ala Ala Leu Arg

610 615 620Tyr Gln Leu Ala Glu Pro Gly Ala His Tyr Pro Thr Tyr Ala Thr Val625 630 635 640Ile Leu Asp Glu Ala Phe Asp Arg Ala Asp Pro Ala Phe Thr Arg Gln

645 650 655Thr Met Asn Val Phe His Ser Phe Gly Phe His Met Val Leu Ala Thr

660 665 670Pro Leu Lys Leu Ile Gln Thr Leu Gly Asp Tyr Val Gly Ser Thr Ile

675 680 685Val Val Ser Tyr Thr Glu Lys Pro Asn Ala Gln Gly Ala Ile Gln Gly

690695700 Asn Ser Ser Phe Ser Arg Ile Glu Lys 705710<210>313<211>2147<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (2124)<223>FRXA02547<400>313gct gcg cgg ctg acc gtg gat gag tat ccg gcg gcg agg gaa gcg ctt 48Ala Ala Arg Leu Thr Val Asp Glu Tyr Pro Ala Ala Arg Glu Ala Leu 151015 gaa tct gca ggt cag agg aat gta gag gaccga acc cgt gcg gtt gat 96Glu Ser Ala Gly Gln Arg Asn Val Glu Asp Arg Thr Arg Ala Val Asp

20 25 30gag ttc aaa gcg gcg gat caa gag ctg tct tct ttg agt aaa ggc agc 144Glu Phe Lys Ala Ala Asp Gln Glu Leu Ser Ser Leu Ser Lys Gly Ser

35 40 45agt aat att gag tac cgt ttg ctg cag gtg cgg gaa aat ttg tgt cag 192Ser Asn Ile Glu Tyr Arg Leu Leu Gln Val Arg Glu Asn Leu Cys Gln

50 55 60gat ttg ggc gtg agc ccg cgg gat atg ccc ttt gcc ggt gag ctg att 240Asp Leu Gly Val Ser Pro Arg Asp Met Pro Phe Ala Gly Glu Leu Ile 65 70 75 80gat ccg aat aat gcg gaa tgg gaa ccc gtt gtg cag cgc att ttg ggt 288Asp Pro Asn Asn Ala Glu Trp Glu Pro Val Val Gln Arg Ile Leu Gly

85 90 95ggt ttt gct gcg gaa atg ttg gtt cct cat ggg ttg ttg cca cgg gtt 336Gly Phe Ala Ala Glu Met Leu Val Pro His Gly Leu Leu Pro Arg Val

100 105 110cgg gat tgg gta aat gcc aaa cat ttg gca gcg ctg ctg aaa ttc aac 384Arg Asp Trp Val Asn Ala Lys His Leu Ala Ala Leu Leu Lys Phe Asn

115 120 125ggc gtg gtg aca acg ggg gag tac aaa acc tcg cgt ttt ccg gcg gat 432Gly Val Val Thr Thr Gly Glu Tyr Lys Thr Ser Arg Phe Pro Ala Asp

130 135 140tcc ctg atc cga aaa gtt gat gtt gtg gag tcg ccg ttt cgc gat tgg 480Ser Leu Ile Arg Lys Val Asp Val Val Glu Ser Pro Phe Arg Asp Trp145 150 155 160gta aat caa gaa tta ggc aag cgt ttt aat att cgg tgc gtg cgc act 528Val Asn Gln Glu Leu Gly Lys Arg Phe Asn Ile Arg Cys Val Arg Thr

165 170 175cct gag gaa ttg tcg gcg ctg ggg cca cgc gat cag ggc gtg acc att 576Pro Glu Glu Leu Ser Ala Leu Gly Pro Arg Asp Gln Gly Val Thr Ile

180 185 190ttg ggt gtg cga aaa ttt gcg cag cag aca ggc gat ccg acg acg cgt 624Leu Gly Val Arg Lys Phe Ala Gln Gln Thr Gly Asp Pro Thr Thr Arg

195 200 205tgg gaa aaa gat gat cgc cga aag ctg ggg gat cgt tcc aca tac cgt 672Trp Glu Lys Asp Asp Arg Arg Lys Leu Gly Asp Arg Ser Thr Tyr Arg

210 215 220ttg ggt tcc acc aat gat gcc aag gtg gaa acg ctt cgg gaa acc gtg 720Leu Gly Ser Thr Asn Asp Ala Lys Val Glu Thr Leu Arg Glu Thr Val225 230 235 240aaa gct ggc aaa gca gtt gtg cag gca gct gat aat cgc att gct gca 768Lys Ala Gly Lys Ala Val Val Gln Ala Ala Asp Asn Arg Ile Ala Ala

245 250 255aac cgc gct gag ctg cgg gaa ctt gaa cgg cag tat caa gct tcg caa 816Asn Arg Ala Glu Leu Arg Glu Leu Glu Arg Gln Tyr Gln Ala Ser Gln

260 265 270gaa att ttg aaa gtg tcg tgg gct cag att gat gtg gaa tca gcc gac 864Glu Ile Leu Lys Val Ser Trp Ala Gln Ile Asp Val Glu Ser Ala Asp

275 280 285gcg gcg att gct gag ctg gac cga ttg ctg gaa gag ctg aac aac act 912Ala Ala Ile Ala Glu Leu Asp Arg Leu Leu Glu Glu Leu Asn Asn Thr

290 295 300cca gag gcc acc gag ctt tcc gcg cgg cat gag gcg gcg aag cag acg 960Pro Glu Ala Thr Glu Leu Ser Ala Arg His Glu Ala Ala Lys Gln Thr305 310 315 320ctc gcg agg gtt tct gac ttg ctt gtc gca gct cag agt gag gaaacc 1008Leu Ala Arg Val Ser Asp Leu Leu Val Ala Ala Gln Ser Glu Glu Thr

325 330 335gtg gcg tcg atg aac ctg aaa cgc gcc gaa act gaa ttg aaa cgg ctc 1056Val Ala Ser Met Asn Leu Lys Arg Ala Glu Thr Glu Leu Lys Arg Leu

340 345 350gaa agc ctg ccg gtt gcg gag gtt tct gaa gaa atc gcg cgg gaa gtg 1104Glu Ser Leu Pro Val Ala Glu Val Ser Glu Glu Ile Ala Arg Glu Val

355 360 365gag aaa cta ttt ctt gcc aac acc cgc cgg gtt cac gcc gcc aac gtg 1152Glu Lys Leu Phe Leu Ala Asn Thr Arg Arg Val His Ala Ala Asn Val

370 375 380gat gag cag acc att gcg ctg cgc gag gat ctg gac aaa caa atc gat 1200Asp Glu Gln Thr Ile Ala Leu Arg Glu Asp Leu Asp Lys Gln Ile Asp385 390 395 400gcc aat gag gca gaa ctt cga cgt tgt gaa aac caa att gtt ggc att 1248Ala Asn Glu Ala Glu Leu Arg Arg Cys Glu Asn Gln Ile Val Gly Ile

405 410 415ttg cgc agc tat att gaa acg tgg cct gcg aac cgc gct gac tta caa 1296Leu Arg Ser Tyr Ile Glu Thr Trp Pro Ala Asn Arg Ala Asp Leu Gln

420 425 430gcc gaa cct gag ttt gtt ggt gag gcc atc aac cgc ctc ggc gag ctt 1344Ala Glu Pro Glu Phe Val Gly Glu Ala Ile Asn Arg Leu Gly Glu Leu

435 440 445cgc agc gat cgt ttg gca gaa ttc acg gcc aaa ttc cta ggg ctc atg 1392Arg Ser Asp Arg Leu Ala Glu Phe Thr Ala Lys Phe Leu Gly Leu Met

450 455 460aac gag atg tcc acc cga aac ctc ggc caa atc tcg cgg cgt cta cgt 1440Asn Glu Met Ser Thr Arg Asn Leu Gly Gln Ile Ser Arg Arg Leu Arg465 470475 480gat gcg cgc cgg gaa atc gag gag cgc atc gag ccg atc aac gcc tcc 1488Asp Ala Arg Arg Glu Ile Glu Glu Arg Ile Glu Pro Ile Asn Ala Ser

485 490 495ttg gcg cag tcg gaa ttc aac gaa ggt cgc ttc ctg cac atc gac atc 1536Leu Ala Gln Ser Glu Phe Asn Glu Gly Arg Phe Leu His Ile Asp Ile

500 505 510cgt gat caa agt ggt ccg att gtg agg gaa ttc cag cag aaa ctt gat 1584Arg Asp Gln Ser Gly Pro Ile Val Arg Glu Phe Gln Gln Lys Leu Asp

515 520 525gcc gct acc agc ggt gac ctg gga acc agt acc gag aaa caa gcc ttc 1632Ala Ala Thr Ser Gly Asp Leu Gly Thr Ser Thr Glu Lys Gln Ala Phe

530 535 540gcc cgt tat gcg ctg atc gct gaa atc att tcc aaa ctc gcc tcc cac 1680Ala Arg Tyr Ala Leu Ile Ala Glu Ile Ile Ser Lys Leu Ala Ser His545 550 555 560gac tcc gcc gac gcc cgc tgg cgc aac acc gtt cta gac acc cgc cgc 1728Asp Ser Ala Asp Ala Arg Trp Arg Asn Thr Val Leu Asp Thr Arg Arg

565 570 575cac gtt cgc ttc atc ggc ctc gag cgc gat tcc gac ggc gca acc gtc 1776His Val Arg Phe Ile Gly Leu Glu Arg Asp Ser Asp Gly Ala Thr Val

580 585 590aac acc tac gtc gac tcc gca tca ctt tca ggc gga caa gcc cag aag 1824Asn Thr Tyr Val Asp Ser Ala Ser Leu Ser Gly Gly Gln Ala Gln Lys

595 600 605ctg gtg ttt ttc tgc ctc gcc gct gcc ttg cgc tac cag cta gcc gaa 1872Leu Val Phe Phe Cys Leu Ala Ala Ala Leu Arg Tyr Gln Leu Ala Glu

610 615 620ccc ggc gcc cat tat ccc acc tac gcc acc gtc att ctg gac gaa gcc 1920Pro Gly Ala His Tyr Pro Thr Tyr Ala Thr Val Ile Leu Asp Glu Ala625 630 635 640ttc gac cgc gcc gac ccc gcc ttc acc cgc caa acc atg aac gtc ttc 1968Phe Asp Arg Ala Asp Pro Ala Phe Thr Arg Gln Thr Met Asn Val Phe

645 650 655cac agc ttc ggc ttc cac atg gtg ctc gcg acc ccg ctg aaa ctt atc 2016His Ser Phe Gly Phe His Met Val Leu Ala Thr Pro Leu Lys Leu Ile

660 665 670caa acc ctc ggc gat tat gtc ggc tcc acc atc gtg gtc agc tac acc 2064Gln Thr Leu Gly Asp Tyr Val Gly Ser Thr Ile Val Val Ser Tyr Thr

675 680 685gaa aaa cca aac gcc cag ggc gca att cag ggc aat tcc agt ttc tct 2112Glu Lys Pro Asn Ala Gln Gly Ala Ile Gln Gly Asn Ser Ser Phe Ser

690695700 agg atc gag aaa taacatgcca ttgtttatcg acg 2147Arg Ile Glu Lys705<210>314<211>708<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>314Ala Ala Arg Leu Thr Val Asp Glu Tyr Pro Ala Ala Arg Glu Ala Leu 151015 Glu Ser Ala Gly Gln Arg Asn Val Glu Asp Arg Thr Arg Ala Val Asp

20 25 30Glu Phe Lys Ala Ala Asp Gln Glu Leu Ser Ser Leu Ser Lys Gly Ser

35 40 45Ser Asn Ile Glu Tyr Arg Leu Leu Gln Val Arg Glu Asn Leu Cys Gln

50 55 60Asp Leu Gly Val Ser Pro Arg Asp Met Pro Phe Ala Gly Glu Leu Ile 65 70 75 80Asp Pro Asn Asn Ala Glu Trp Glu Pro Val Val Gln Arg Ile Leu Gly

85 90 95Gly Phe Ala Ala Glu Met Leu Val Pro His Gly Leu Leu Pro Arg Val

100 105 110Arg Asp Trp Val Asn Ala Lys His Leu Ala Ala Leu Leu Lys Phe Asn

115 120 125Gly Val Val Thr Thr Gly Glu Tyr Lys Thr Ser Arg Phe Pro Ala Asp

130 135 140Ser Leu Ile Arg Lys Val Asp Val Val Glu Ser Pro Phe Arg Asp Trp145 150 155 160Val Asn Gln Glu Leu Gly Lys Arg Phe Asn Ile Arg Cys Val Arg Thr

165 170 175Pro Glu Glu Leu Ser Ala Leu Gly Pro Arg Asp Gln Gly Val Thr Ile

180 185 190Leu Gly Val Arg Lys Phe Ala Gln Gln Thr Gly Asp Pro Thr Thr Arg

195 200 205Trp Glu Lys Asp Asp Arg Arg Lys Leu Gly Asp Arg Ser Thr Tyr Arg

210 215 220Leu Gly Ser Thr Asn Asp Ala Lys Val Glu Thr Leu Arg Glu Thr Val225 230 235 240Lys Ala Gly Lys Ala Val Val Gln Ala Ala Asp Asn Arg Ile Ala Ala

245 250 255Asn Arg Ala Glu Leu Arg Glu Leu Glu Arg Gln Tyr Gln Ala Ser Gln

260 265 270Glu Ile Leu Lys Val Ser Trp Ala Gln Ile Asp Val Glu Ser Ala Asp

275 280 285Ala Ala Ile Ala Glu Leu Asp Arg Leu Leu Glu Glu Leu Asn Asn Thr

290 295 300Pro Glu Ala Thr Glu Leu Ser Ala Arg His Glu Ala Ala Lys Gln Thr305 310 315 320Leu Ala Arg Val Ser Asp Leu Leu Val Ala Ala Gln Ser Glu Glu Thr

325 330 335Val Ala Ser Met Asn Leu Lys Arg Ala Glu Thr Glu Leu Lys Arg Leu

340 345 350Glu Ser Leu Pro Val Ala Glu Val Ser Glu Glu Ile Ala Arg Glu Val

355 360 365Glu Lys Leu Phe Leu Ala Asn Thr Arg Arg Val His Ala Ala Asn Val

370 375 380Asp Glu Gln Thr Ile Ala Leu Arg Glu Asp Leu Asp Lys Gln Ile Asp385 390 395 400Ala Asn Glu Ala Glu Leu Arg Arg Cys Glu Asn Gln Ile Val Gly Ile

405 410 415Leu Arg Ser Tyr Ile Glu Thr Trp Pro Ala Asn Arg Ala Asp Leu Gln

420 425 430Ala Glu Pro Glu Phe Val Gly Glu Ala Ile Asn Arg Leu Gly Glu Leu

435 440 445Arg Ser Asp Arg Leu Ala Glu Phe Thr Ala Lys Phe Leu Gly Leu Met

450 455 460Asn Glu Met Ser Thr Arg Asn Leu Gly Gln Ile Ser Arg Arg Leu Arg465 470 475 480Asp Ala Arg Arg Glu Ile Glu Glu Arg Ile Glu Pro Ile Asn Ala Ser

485 490 495Leu Ala Gln Ser Glu Phe Asn Glu Gly Arg Phe Leu His Ile Asp Ile

500 505 510Arg Asp Gln Ser Gly Pro Ile Val Arg Glu Phe Gln Gln Lys Leu Asp

515 520 525Ala Ala Thr Ser Gly Asp Leu Gly Thr Ser Thr Glu Lys Gln Ala Phe

530 535 540Ala Arg Tyr Ala Leu Ile Ala Glu Ile Ile Ser Lys Leu Ala Ser His545 550555 560Asp Ser Ala Asp Ala Arg Trp Arg Asn Thr Val Leu Asp Thr Arg Arg

565 570 575His Val Arg Phe Ile Gly Leu Glu Arg Asp Ser Asp Gly Ala Thr Val

580 585 590Asn Thr Tyr Val Asp Ser Ala Ser Leu Ser Gly Gly Gln Ala Gln Lys

595 600 605Leu Val Phe Phe Cys Leu Ala Ala Ala Leu Arg Tyr Gln Leu Ala Glu

610 615 620Pro Gly Ala His Tyr Pro Thr Tyr Ala Thr Val Ile Leu Asp Glu Ala625 630 635 640Phe Asp Arg Ala Asp Pro Ala Phe Thr Arg Gln Thr Met Asn Val Phe

645 650 655His Ser Phe Gly Phe His Met Val Leu Ala Thr Pro Leu Lys Leu Ile

660 665 670Gln Thr Leu Gly Asp Tyr Val Gly Ser Thr Ile Val Val Ser Tyr Thr

675 680 685Glu Lys Pro Asn Ala Gln Gly Ala Ile Gln Gly Asn Ser Ser Phe Ser

690695700 Arg Ile Glu Lys705<210>315<211>1152<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1129)<223>RXN02571<400>315tggacaggcc ggggccgcgt acggtgttgg ttgaggtggt ggaggggcgc gtcgaaaagc 60attgtcgctg gttgttgccg cttttggcag tcgggatggc gtg gtg gct cta act 115

Val Val Ala Leu Thr

l 5caa atc gtc gga ccg tcc ggc tcc ggg ctc acg cgg gaa ttg gaa aaa 163Gln Ile Val Gly Pro Ser Gly Ser Gly Leu Thr Arg Glu Leu Glu Lys

10 15 20cgc tac cgg gaa acg ccc gga gcg gtg atg ctg acc gcc gac ccg cgc 211Arg Tyr Arg Glu Thr Pro Gly Ala Val Met Leu Thr Ala Asp Pro Arg

25 30 35gcg cat atc acc tac ctg cgc gcg aca gtc gcc gag gag ctg gcc ttt 259Ala His Ile Thr Tyr Leu Arg Ala Thr Val Ala Glu Glu Leu Ala Phe

40 45 50ggg ctg gaa caa cgc ggc atc gta ccc gcg cag atg tgg gag cgc gtc 307Gly Leu Glu Gln Arg Gly Ile Val Pro Ala Gln Met Trp Glu Arg Val

55 60 65cga aac atc ggg ctc ggc ctc gag aat ctg cta gac cgc gca ccc gcg 355Arg Asn Ile Gly Leu Gly Leu Glu Asn Leu Leu Asp Arg Ala Pro Ala 70 75 80 85caa ctt tcc ggc ggg caa aca cgg cgg ctg gcg atc ggc acc gtc gcc 403Gln Leu Ser Gly Gly Gln Thr Arg Arg Leu Ala Ile Gly Thr Val Ala

90 95 100atc tta gag gcg cca acg atg ctt ctc gac gac ccc ctc tcc ggt ctt 451Ile Leu Glu Ala Pro Thr Met Leu Leu Asp Asp Pro Leu Ser Gly Leu

105 110 115gat acc tcc tcg cga gcc caa ctc atc aca atg ttg gaa tca tat gag 499Asp Thr Ser Ser Arg Ala Gln Leu Ile Thr Met Leu Glu Ser Tyr Glu

120 125 130ggc gat gtc atc gtc gct gcg cac aag cgg tgg ctc gac gcg ccg act 547Gly Asp Val Ile Val Ala Ala His Lys Arg Trp Leu Asp Ala Pro Thr

135 140 145gtg tac tta ggg gat ttg gag gag ctg tcc ctg cct gcg cgg gtg gaa 595Val Tyr Leu Gly Asp Leu Glu Glu Leu Ser Leu Pro Ala Arg Val Glu150 155 160 165ttt tcc ggt cca tcg cga acg ttt tca gcg att aca gga acc cgc gga 643Phe Ser Gly Pro Ser Arg Thr Phe Ser Ala Ile Thr Gly Thr Arg Gly

170 175 180caa caa cgc cga cgc tgg tgg caa ttc aac gaa tcc caa cca cag ttt 691Gln Gln Arg Arg Arg Trp Trp Gln Phe Asn Glu Ser Gln Pro Gln Phe

185 190 195cag atc ggc ccc ctg gat att act gtt tct gca ggt caa gtg ctg tgg 739Gln Ile Gly Pro Leu Asp Ile Thr Val Ser Ala Gly Gln Val Leu Trp

200 205 210ttg cag ggt ccc aat ggt tca ggg aag tcc aca ctc ctg cgt ggt ctt 787Leu Gln Gly Pro Asn Gly Ser Gly Lys Ser Thr Leu Leu Arg Gly Leu

215 220 225gcc aat gaa ccc ggc act gaa ttg atg ctg caa aac cct agc gat caa 835Ala Asn Glu Pro Gly Thr Glu Leu Met Leu Gln Asn Pro Ser Asp Gln230 235 240 245gtc att gac tcc act gtt gct aat tgg gtg cca ggc agt aac agt gaa 883Val Ile Asp Ser Thr Val Ala Asn Trp Val Pro Gly Ser Asn Ser Glu

250 255 260gaa cat ccg ctg gat tta tcg caa cgc gaa ctc cgc ctt gcc caa tgc 931Glu His Pro Leu Asp Leu Ser Gln Arg Glu Leu Arg Leu Ala Gln Cys

265 270 275gac gca gcc ctg ggt aat aac ccg gaa gtt ttg ctt gct gat gaa ccc 979Asp Ala Ala Leu Gly Asn Asn Pro Glu Val Leu Leu Ala Asp Glu Pro

280 285 290gac gtc ggc ctt gat gtc ggc ggt cga aac gcc atc cac cag cgc ttt 1027Asp Val Gly Leu Asp Val Gly Gly Arg Asn Ala Ile His Gln Arg Phe

295 300 305gcg gat ttc tta ggg aat ggg gga gcg ctg atc ctg acc tgc cat gat 1075Ala Asp Phe Leu Gly Asn Gly Gly Ala Leu Ile Leu Thr Cys His Asp310315 320 325gaa acc ttc gtg gca gag gta gct gaa tac gcg ata gtg aag gaa atg 1123Glu Thr Phe Val Ala Glu Val Ala Glu Tyr Ala Ile Val Lys Glu Met

330335340 ggg ctc taggtttctt tggaccaaac cac 1152Gly Leu<210>316<211>343<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>316Val Val Ala Leu Thr Gln Ile Val Gly Pro Ser Gly Ser Gly Leu Thr 151015 Arg Glu Leu Glu Lys Arg Tyr Arg Glu Thr Pro Gly Ala Val Met Leu

20 25 30Thr Ala Asp Pro Arg Ala His Ile Thr Tyr Leu Arg Ala Thr Val Ala

35 40 45Glu Glu Leu Ala Phe Gly Leu Glu Gln Arg Gly Ile Val Pro Ala Gln

50 55 60Met Trp Glu Arg Val Arg Asn Ile Gly Leu Gly Leu Glu Asn Leu Leu 65 70 75 80Asp Arg Ala Pro Ala Gln Leu Ser Gly Gly Gln Thr Arg Arg Leu Ala

85 90 95Ile Gly Thr Val Ala Ile Leu Glu Ala Pro Thr Met Leu Leu Asp Asp

100 105 110Pro Leu Ser Gly Leu Asp Thr Ser Ser Arg Ala Gln Leu Ile Thr Met

115 120 125Leu Glu Ser Tyr Glu Gly Asp Val Ile Val Ala Ala His Lys Arg Trp

130 135 140Leu Asp Ala Pro Thr Val Tyr Leu Gly Asp Leu Glu Glu Leu Ser Leu145 150 155 160Pro Ala Arg Val Glu Phe Ser Gly Pro Ser Arg Thr Phe Ser Ala Ile

165 170 175Thr Gly Thr Arg Gly Gln Gln Arg Arg Arg Trp Trp Gln Phe Asn Glu

180 185190Ser Gln Pro Gln Phe Gln Ile Gly Pro Leu Asp Ile Thr Val Ser Ala

195 200 205Gly Gln Val Leu Trp Leu Gln Gly Pro Asn Gly Ser Gly Lys Ser Thr

210 215 220Leu Leu Arg Gly Leu Ala Asn Glu Pro Gly Thr Glu Leu Met Leu Gln225 230 235 240Asn Pro Ser Asp Gln Val Ile Asp Ser Thr Val Ala Asn Trp Val Pro

245 250 255Gly Ser Asn Ser Glu Glu His Pro Leu Asp Leu Ser Gln Arg Glu Leu

260 265 270Arg Leu Ala Gln Cys Asp Ala Ala Leu Gly Asn Asn Pro Glu Val Leu

275 280 285Leu Ala Asp Glu Pro Asp Val Gly Leu Asp Val Gly Gly Arg Asn Ala

290 295 300Ile His Gln Arg Phe Ala Asp Phe Leu Gly Asn Gly Gly Ala Leu Ile305 310 315 320Leu Thr Cys His Asp Glu Thr Phe Val Ala Glu Val Ala Glu Tyr Ala

325 330 335Ile Val Lys Glu Met Gly Leu

340<210>317<211>1152<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1129)<223>FRXA02571<400>317tggacaggcc ggggccgcgt acggtgttgg ttgaggtggt ggaggggcgc gtcgaaaagc 60attgtcgctg gttgttgccg cttttggcag tcgggatggc gtg gtg gct cta act 115

Val Val Ala Leu Thr

1 5caa atc gtc gga ccg tcc ggc tcc ggg ctc acg cgg gaa ttg gaa aaa 163Gln Ile Val Gly Pro Ser Gly Ser Gly Leu Thr Arg Glu Leu Glu Lys

10 15 20cgc tac cgg gaa acg ccc gga gcg gtg atg ctg acc gcc gac ccg cgc 211Arg Tyr Arg Glu Thr Pro Gly Ala Val Met Leu Thr Ala Asp Pro Arg

25 30 35gcg cat atc acc tac ctg cgc gcg aca gtc gcc gag gag ctg gcc ttt 259Ala His Ile Thr Tyr Leu Arg Ala Thr Val Ala Glu Glu Leu Ala Phe

40 45 50ggg ctg gaa caa cgc ggc atc gta ccc gcg cag atg tgg gag cgc gtc 307Gly Leu Glu Gln Arg Gly Ile Val Pro Ala Gln Met Trp Glu Arg Val

55 60 65cga aac atc ggg ctc ggc ctc gag aat ctg cta gac cgc gca ccc gcg 355Arg Asn Ile Gly Leu Gly Leu Glu Asn Leu Leu Asp Arg Ala Pro Ala 70 75 80 85caa ctt tcc ggc ggg caa aca cgg cgg ctg gcg atc ggc acc gtc gcc 403Gln Leu Ser Gly Gly Gln Thr Arg Arg Leu Ala Ile Gly Thr Val Ala

90 95 100atc tta gag gcg cca acg atg ctt ctc gac gac ccc ctc tcc ggt ctt 451Ile Leu Glu Ala Pro Thr Met Leu Leu Asp Asp Pro Leu Ser Gly Leu

105 110 115gat acc tcc tcg cga gcc caa ctc atc aca atg ttg gaa tca tat gag 499Asp Thr Ser Ser Arg Ala Gln Leu Ile Thr Met Leu Glu Ser Tyr Glu

120 125 130ggc gat gtc atc gtc gct gcg cac aag cgg tgg ctc gac gcg ccg act 547Gly Asp Val Ile Val Ala Ala His Lys Arg Trp Leu Asp Ala Pro Thr

135 140 145gtg tac tta ggg gat ttg gag gag ctg tcc ctg cct gcg cgg gtg gaa 595Val Tyr Leu Gly Asp Leu Glu Glu Leu Ser Leu Pro Ala Arg Val Glu150 155 160 165ttt tcc ggt cca tcg cga acg ttt tca gcg att aca gga acc cgc gga 643Phe Ser Gly Pro Ser Arg Thr Phe Ser Ala Ile Thr Gly Thr Arg Gly

170 175 180caa caa cgc cga cgc tgg tgg caa ttc aac gaa tcc caa cca cag ttt 691Gln Gln Arg Arg Arg Trp Trp Gln Phe Asn Glu Ser Gln Pro Gln Phe

185 190 195cag atc ggc ccc ctg gat att act gtt tct gca ggt caa gtg ctg tgg 739Gln Ile Gly Pro Leu Asp Ile Thr Val Ser Ala Gly Gln Val Leu Trp

200 205 210ttg cag ggt ccc aat ggt tca ggg aag tcc aca ctc ctg cgt ggt ctt 787Leu Gln Gly Pro Asn Gly Ser Gly Lys Ser Thr Leu Leu Arg Gly Leu

215 220 225gcc aat gaa ccc ggc act gaa ttg atg ctg caa aac cct agc gat caa 835Ala Asn Glu Pro Gly Thr Glu Leu Met Leu Gln Asn Pro Ser Asp Gln230 235 240 245gtc att gac tcc act gtt gct aat tgg gtg cca ggc agt aac agt gaa 883Val Ile Asp Ser Thr Val Ala Asn Trp Val Pro Gly Ser Asn Ser Glu

250 255 260gaa cat ccg ctg gat tta tcg caa cgc gaa ctc cgc ctt gcc caa tgc 931Glu His Pro Leu Asp Leu Ser Gln Arg Glu Leu Arg Leu Ala Gln Cys

265 270 275gac gca gcc ctg ggt aat aac ccg gaa gtt ttg ctt gct gat gaa ccc 979Asp Ala Ala Leu Gly Asn Asn Pro Glu Val Leu Leu Ala Asp Glu Pro

280 285 290gac gtc ggc ctt gat gtc ggc ggt cga aac gcc atc cac cag cgc ttt 1027Asp Val Gly Leu Asp Val Gly Gly Arg Asn Ala Ile His Gln Arg Phe

295 300 305gcg gat ttc tta ggg aat ggg gga gcg ctg atc ctg acc tgc cat gat 1075Ala Asp Phe Leu Gly Asn Gly Gly Ala Leu Ile Leu Thr Cys HisAsp310 315 320 325gaa acc ttc gtg gca gag gta gct gaa tac gcg ata gtg aag gaa atg 1123Glu Thr Phe Val Ala Glu Val Ala Glu Tyr Ala Ile Val Lys Glu Met

330335340 ggg ctc taggtttctt tggaccaaac cac 1152Gly Leu<210>318<211>343<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>318Val Val Ala Leu Thr Gln Ile Val Gly Pro Ser Gly Ser Gly Leu Thr 151015 Arg Glu Leu Glu Lys Arg Tyr Arg Glu Thr Pro Gly Ala Val Met Leu

20 25 30Thr Ala Asp Pro Arg Ala His Ile Thr Tyr Leu Arg Ala Thr Val Ala

35 40 45Glu Glu Leu Ala Phe Gly Leu Glu Gln Arg Gly Ile Val Pro Ala Gln

50 55 60Met Trp Glu Arg Val Arg Asn Ile Gly Leu Gly Leu Glu Asn Leu Leu 65 70 75 80Asp Arg Ala Pro Ala Gln Leu Ser Gly Gly Gln Thr Arg Arg Leu Ala

85 90 95Ile Gly Thr Val Ala Ile Leu Glu Ala Pro Thr Met Leu Leu Asp Asp

100 105 110Pro Leu Ser Gly Leu Asp Thr Ser Ser Arg Ala Gln Leu Ile Thr Met

115 120 125Leu Glu Ser Tyr Glu Gly Asp Val Ile Val Ala Ala His Lys Arg Trp

130 135 140Leu Asp Ala Pro Thr Val Tyr Leu Gly Asp Leu Glu Glu Leu Ser Leu145 150 155 160Pro Ala Arg Val Glu Phe Ser Gly Pro Ser Arg Thr Phe Ser Ala Ile

165 170 175Thr Gly Thr Arg Gly Gln Gln Arg Arg Arg Trp Trp Gln Phe Asn Glu

180 185 190Ser Gln Pro Gln Phe Gln Ile Gly Pro Leu Asp Ile Thr Val Ser Ala

195 200 205Gly Gln Val Leu Trp Leu Gln Gly Pro Asn Gly Ser Gly Lys Ser Thr

210 215 220Leu Leu Arg Gly Leu Ala Asn Glu Pro Gly Thr Glu Leu Met Leu Gln225 230 235 240Asn Pro Ser Asp Gln Val Ile Asp Ser Thr Val Ala Asn Trp Val Pro

245 250 255Gly Ser Asn Ser Glu Glu His Pro Leu Asp Leu Ser Gln Arg Glu Leu

260 265 270Arg Leu Ala Gln Cys Asp Ala Ala Leu Gly Asn Asn Pro Glu Val Leu

275 280 285Leu Ala Asp Glu Pro Asp Val Gly Leu Asp Val Gly Gly Arg Asn Ala

290 295 300Ile His Gln Arg Phe Ala Asp Phe Leu Gly Asn Gly Gly Ala Leu Ile305 310 315 320Leu Thr Cys His Asp Glu Thr Phe Val Ala Glu Val Ala Glu Tyr Ala

325 330 335Ile Val Lys Glu Met Gly Leu

340<210>319<211>1746<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1723)<223>RXN02074<400>319cgggggaagg ccgtgtcgca tgctcgggct agccttggat ctcaagaaga attcgactgg 60tttaaagtct gggctttaag tgcagaaagg ttgtggattg atg cgc tcc ctg ctt 115

Met Arg Ser Leu Leu

1 5cgt gat atc cct gcg gtg ggt tgg cta atc acc gcg acg att gtt gtg 163Arg Asp Ile Pro Ala Val Gly Trp Leu Ile Thr Ala Thr Ile Val Val

10 15 20cgc acg ctc gtt gtt gcg ctg gtc atc gtt ggg atc ggc ttg ctt atc 211Arg Thr Leu Val Val Ala Leu Val Ile Val Gly Ile Gly Leu Leu Ile

25 30 35gac gtc ccc tcg ccc gct cat tca gcc atg ttg tgg tgg gtt ctg gca 259Asp Val Pro Ser Pro Ala His Ser Ala Met Leu Trp Trp Val Leu Ala

40 45 50ggt gcc acg gca gca gct gcg ctg ctg tgc gcg gaa gcg gtg ctc ccc 307Gly Ala Thr Ala Ala Ala Ala Leu Leu Cys Ala Glu Ala Val Leu Pro

55 60 65caa cgt att cgt gca cga gtt gaa cga tcc tgg cgg cgg cag ttg gct 355Gln Arg Ile Arg Ala Arg Val Glu Arg Ser Trp Arg Arg Gln Leu Ala 70 75 80 85gct aaa aat ctg gag ctg aat tcc agt tcg tca gat gat gcc cag ttg 403Ala Lys Asn Leu Glu Leu Asn Ser Ser Ser Ser Asp Asp Ala Gln Leu

90 95 100atc aca ctg gca act gaa gcc acc tca aaa gca tcc act tac aca gtg 451Ile Thr Leu Ala Thr Glu Ala Thr Ser Lys Ala Ser Thr Tyr Thr Val

105 110 115atg ttt ctg ggg cct tac ttt gca gta ttt ttg gcc cca ctg aca gtt 499Met Phe Leu Gly Pro Tyr Phe Ala Val Phe Leu Ala Pro Leu Thr Val

120 125 130att gcc gtt gtc ggc gcg gct att tcc tgg ccg att gcg ggg ata ctg 547Ile Ala Val Val Gly Ala Ala Ile Ser Trp Pro Ile Ala Gly Ile Leu

135 140 145tgc ctc ggg ttg tgc gtg ata cct ttc gtt att tct tgg gca cag cgc 595Cys Leu Gly Leu Cys Val Ile Pro Phe Val Ile Ser Trp Ala Gln Arg150 155 160165atg ttg aaa ggc gct ggc gcg gga tac ggg cga gca tct ggg cag ttg 643Met Leu Lys Gly Ala Gly Ala Gly Tyr Gly Arg Ala Ser Gly Gln Leu

170 175 180gca ggc gtg ttt ttg gaa tcg gtg cgc aca cta ggc acc acg atg atg 691Ala Gly Val Phe Leu Glu Ser Val Arg Thr Leu Gly Thr Thr Met Met

185 190 195ctg aat gcc gct ggg cag cgc agg cag atc atc aca cag cgc gca gag 739Leu Asn Ala Ala Gly Gln Arg Arg Gln Ile Ile Thr Gln Arg Ala Glu

200 205 210aat atg cgc tcc caa gtg atg tca ttg ctg tac cga aat cag ttg atg 787Asn Met Arg Ser Gln Val Met Ser Leu Leu Tyr Arg Asn Gln Leu Met

215 220 225att ctg gtg acc gac ggc gtg ttt gga gtt gcc acc aca atg gtt gct 835Ile Leu Val Thr Asp Gly Val Phe Gly Val Ala Thr Thr Met Val Ala230 235 240 245gcg gtg ttt gcc att gga gga ttc ttt tca ggc tct ctt act ctc ggc 883Ala Val Phe Ala Ile Gly Gly Phe Phe Ser Gly Ser Leu Thr Leu Gly

250 255 260caa gct gta gca ctc gta ttg ctg gcc agg ctg ctt att gat ccc atc 931Gln Ala Val Ala Leu Val Leu Leu Ala Arg Leu Leu Ile Asp Pro Ile

265 270 275aac cgc atg ggt cgc acg ttt tac acc ggc atg gca ggc aaa ccc tcg 979Asn Arg Met Gly Arg Thr Phe Tyr Thr Gly Met Ala Gly Lys Pro Ser

280 285 290ctg atc gcc att gaa aaa gcc ctc gcg aca acc ttt act gat cag cca 1027Leu Ile Ala Ile Glu Lys Ala Leu Ala Thr Thr Phe Thr Asp Gln Pro

295 300 305act caa cag gga cag cgc cac gat ggg gat ctg gtg gtc aac aac ttg 1075Thr Gln Gln Gly Gln Arg His Asp Gly Asp Leu Val Val Asn Asn Leu310 315 320 325aag atc gcc cgc gat cac agg gac att gtg cac ggt atc tct ttc agc 1123Lys Ile Ala Arg Asp His Arg Asp Ile Val His Gly Ile Ser Phe Ser

330 335 340att ccc cgc ggt tcc cac atc gcg gtg gta ggt ccc agt ggc gct ggt 1171Ile Pro Arg Gly Ser His Ile Ala Val Val Gly Pro Ser Gly Ala Gly

345 350 355aaa tcc tct gtg gct cta gcg ttg tcc gga ctt tta gag ttt gat ggt 1219Lys Ser Ser Val Ala Leu Ala Leu Ser Gly Leu Leu Glu Phe Asp Gly

360 365 370gcg att tcc ctc ggc ggc cac aac tgt gag atg tta gat ctt cgc gcc 1267Ala Ile Ser Leu Gly Gly His Asn Cys Glu Met Leu Asp Leu Arg Ala

375 380 385tca gtc agt ttc gtg ccc caa tcc ccc acg ctg ttt agc gga agc atc 1315Ser Val Ser Phe Val Pro Gln Ser Pro Thr Leu Phe Ser Gly Ser Ile390 395 400 405aaa agc aat atc gat ctg gcg cgc acg ggt gtt gat tct gat cac atc 1363Lys Ser Asn Ile Asp Leu Ala Arg Thr Gly Val Asp Ser Asp His Ile

410 415 420cac gca gca ctt tta ggc gaa gaa ctc ccc gcg gac ctc aaa gtc ggt 1411His Ala Ala Leu Leu Gly Glu Glu Leu Pro Ala Asp Leu Lys Val Gly

425 430 435gaa acc ggc aaa ggt gtc tcc ggc ggc caa gca gca cgc att tcc att 1459Glu Thr Gly Lys Gly Val Ser Gly Gly Gln Ala Ala Arg Ile Ser Ile

440 445 450gcc cga ggt tta gta aag aat gct gcc gtg att gtt ctc gac gag gcg 1507Ala Arg Gly Leu Val Lys Asn Ala Ala Val Ile Val Leu Asp Glu Ala

455 460 465acc gca caa ctc gac tac acc aac gcc cgc cag gtt cga cat ctt gcc 1555Thr Ala Gln Leu Asp Tyr Thr Asn Ala Arg Gln Val Arg His Leu Ala470 475 480 485aaa tcc ctt gag tgc acg ttg gtt gag atc acc cac cgc cca tca gaa 1603Lys Ser Leu Glu Cys Thr Leu Val Glu Ile Thr His Arg Pro Ser Glu

490 495 500gcc ctc gat gca gac ttc atc att gtt tta gag gat ggc caa ttg acc 1651Ala Leu Asp Ala Asp Phe Ile Ile Val Leu Glu Asp Gly Gln Leu Thr

505 510 515atg atg gat aca ccc agc aac gtt tcc cag cac aat gcg ttt ttc cgc 1699Met Met Asp Thr Pro Ser Asn Val Ser Gln His Asn Ala Phe Phe Arg

520 525 530acc gct gtg atg gag gaa gaa caa tgatttcccg acttctccaa ttg 1746Thr Ala Val Met Glu Glu Glu Gln

535540<210>320<211>541<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>320Met Arg Ser Leu Leu Arg Asp Ile Pro Ala Val Gly Trp Leu Ile Thr 151015 Ala Thr Ile Val Val Arg Thr Leu Val Val Ala Leu Val Ile Val Gly

20 25 30Ile Gly Leu Leu Ile Asp Val Pro Ser Pro Ala His Ser Ala Met Leu

35 40 45Trp Trp Val Leu Ala Gly Ala Thr Ala Ala Ala Ala Leu Leu Cys Ala

50 55 60Glu Ala Val Leu Pro Gln Arg Ile Arg Ala Arg Val Glu Arg Ser Trp 65 70 75 80Arg Arg Gln Leu Ala Ala Lys Asn Leu Glu Leu Asn Ser Ser Ser Ser

85 90 95Asp Asp Ala Gln Leu Ile Thr Leu Ala Thr Glu Ala Thr Ser Lys Ala

100 105 110Ser Thr Tyr Thr Val Met Phe Leu Gly Pro Tyr Phe Ala Val Phe Leu

115 120 125Ala Pro Leu Thr Val Ile Ala Val Val Gly Ala Ala Ile Ser Trp Pro

130 135 140Ile Ala Gly Ile Leu Cys Leu Gly Leu Cys Val Ile Pro Phe Val Ile145 150 155 160Ser Trp Ala Gln Arg Met Leu Lys Gly Ala Gly Ala Gly Tyr Gly Arg

165 170 175Ala Ser Gly Gln Leu Ala Gly Val Phe Leu Glu Ser Val Arg Thr Leu

180 185 190Gly Thr Thr Met Met Leu Asn Ala Ala Gly Gln Arg Arg Gln Ile Ile

195 200 205Thr Gln Arg Ala Glu Asn Met Arg Ser Gln Val Met Ser Leu Leu Tyr

210 215 220Arg Asn Gln Leu Met Ile Leu Val Thr Asp Gly Val Phe Gly Val Ala225 230 235 240Thr Thr Met Val Ala Ala Val Phe Ala Ile Gly Gly Phe Phe Ser Gly

245 250 255Ser Leu Thr Leu Gly Gln Ala Val Ala Leu Val Leu Leu Ala Arg Leu

260 265 270Leu Ile Asp Pro Ile Asn Arg Met Gly Arg Thr Phe Tyr Thr Gly Met

275 280 285Ala Gly Lys Pro Ser Leu Ile Ala Ile Glu Lys Ala Leu Ala Thr Thr

290 295 300Phe Thr Asp Gln Pro Thr Gln Gln Gly Gln Arg His Asp Gly Asp Leu305 310 315 320Val Val Asn Asn Leu Lys Ile Ala Arg Asp His Arg Asp Ile Val His

325 330 335Gly Ile Ser Phe Ser Ile Pro Arg Gly Ser His Ile Ala Val Val Gly

340 345 350Pro Ser Gly Ala Gly Lys Ser Ser Val Ala Leu Ala Leu Ser Gly Leu

355 360 365Leu Glu Phe Asp Gly Ala Ile Ser Leu Gly Gly His Asn Cys Glu Met

370 375 380Leu Asp Leu Arg Ala Ser Val Ser Phe Val Pro Gln Ser Pro Thr Leu385 390 395 400Phe Ser Gly Ser Ile Lys Ser Asn Ile Asp Leu Ala Arg Thr Gly Val

405 410 415Asp Ser Asp His Ile His Ala Ala Leu Leu Gly Glu Glu Leu Pro Ala

420 425 430Asp Leu Lys Val Gly Glu Thr Gly Lys Gly Val Ser Gly Gly Gln Ala

435 440 445Ala Arg Ile Ser Ile Ala Arg Gly Leu Val Lys Asn Ala Ala Val Ile

450 455 460Val Leu Asp Glu Ala Thr Ala Gln Leu Asp Tyr Thr Asn Ala Arg Gln465 470 475 480Val Arg His Leu Ala Lys Ser Leu Glu Cys Thr Leu Val Glu Ile Thr

485 490 495His Arg Pro Ser Glu Ala Leu Asp Ala Asp Phe Ile Ile Val Leu Glu

500 505 510Asp Gly Gln Leu Thr Met Met Asp Thr Pro Ser Asn Val Ser Gln His

515 520 525Asn Ala Phe Phe Arg Thr Ala Val Met Glu Glu Glu Gln

530535540<210>321<211>1746<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1723)<223>FRXA02074<400>321cgggggaagg ccgtgtcgca tgctcgggct agccttggat ctcaagaaga attcgactgg 60tttaaagtct gggctttaag tgcagaaagg ttgtggattg atg cgc tcc ctg ctt 115

Met Arg Ser Leu Leu

1 5cgt gat atc cct gcg gtg ggt tgg cta atc acc gcg acg att gtt gtg 163Arg Asp Ile Pro Ala Val Gly Trp Leu Ile Thr Ala Thr Ile Val Val

10 15 20cgc acg ctc gtt gtt gcg ctg gtc atc gtt ggg atc ggc ttg ctt atc 211Arg Thr Leu Val Val Ala Leu Val Ile Val Gly Ile Gly Leu Leu Ile

25 30 35gac gtc ccc tcg ccc gct cat tca gcc atg ttg tgg tgg gtt ctg gca 259Asp Val Pro Ser Pro Ala His Ser Ala Met Leu Trp Trp Val Leu Ala

40 45 50ggt gcc acg gca gca gct gcg ctg ctg tgc gcg gaa gcg gtg ctc ccc 307Gly Ala Thr Ala Ala Ala Ala Leu Leu Cys Ala Glu Ala Val Leu Pro

55 60 65caa cgt att cgt gca cga gtt gaa cga tcc tgg cgg cgg cag ttg gct 355Gln Arg Ile Arg Ala Arg Val Glu Arg Ser Trp Arg Arg Gln Leu Ala 70 75 80 85gct aaa aat ctg gag ctg aat tcc agt tcg tca gat gat gcc cag ttg 403Ala Lys Asn Leu Glu Leu Ash Ser Ser Ser Ser Asp Asp Ala Gln Leu

90 95 100atc aca ctg gca act gaa gcc acc tca aaa gca tcc act tac aca gtg 451Ile Thr Leu Ala Thr Glu Ala Thr Ser Lys Ala Ser Thr Tyr Thr Val

105 110 115atg ttt ctg ggg cct tac ttt gca gta ttt ttg gcc cca ctg aca gtt 499Met Phe Leu Gly Pro Tyr Phe Ala Val Phe Leu Ala Pro Leu Thr Val

120 125 130att gcc gtt gtc ggc gcg gct att tcc tgg ccg att gcg ggg ata ctg 547Ile Ala Val Val Gly Ala Ala Ile Ser Trp Pro Ile Ala Gly Ile Leu

135 140 145tgc ctc ggg ttg tgc gtg ata cct ttc gtt att tct tgg gca cag cgc 595Cys Leu Gly Leu Cys Val Ile Pro Phe Val Ile Ser Trp Ala Gln Arg150 155 160 165atg ttg aaa ggc gct ggc gcg gga tac ggg cga gca tct ggg cag ttg 643Met Leu Lys Gly Ala Gly Ala Gly Tyr Gly Arg Ala Ser Gly Gln Leu

170 175 180gca ggc gtg ttt ttg gaa tcg gtg cgc aca cta ggc acc acg atg atg 691Ala Gly Val Phe Leu Glu Ser Val Arg Thr Leu Gly Thr Thr Met Met

185 190 195ctg aat gcc gct ggg cag cgc agg cag atc atc aca cag cgc gca gag 739Leu Asn Ala Ala Gly Gln Arg Arg Gln Ile Ile Thr Gln Arg Ala Glu

200 205 210aat atg cgc tcc caa gtg atg tca ttg ctg tac cga aat cag ttg atg 787Asn Met Arg Ser Gln Val Met Ser Leu Leu Tyr Arg Asn Gln Leu Met

215 220 225att ctg gtg acc gac ggc gtg ttt gga gtt gcc acc aca atg gtt gct 835Ile Leu Val Thr Asp Gly Val Phe Gly Val Ala Thr Thr Met Val Ala230 235 240 245gcg gtg ttt gcc att gga gga ttc ttt tca ggc tct ctt act ctc ggc 883Ala Val Phe Ala Ile Gly Gly Phe Phe Ser Gly Ser Leu Thr Leu Gly

250 255 260caa gct gta gca ctc gta ttg ctg gcc agg ctg ctt att gat ccc atc 931Gln Ala Val Ala Leu Val Leu Leu Ala Arg Leu Leu Ile Asp Pro Ile

265 270 275aac cgc atg ggt cgc acg ttt tac acc ggc atg gca ggc aaa ccc tcg 979Asn Arg Met Gly Arg Thr Phe Tyr Thr Gly Met Ala Gly Lys Pro Ser

280 285 290ctg atc gcc att gaa aaa gcc ctc gcg aca acc ttt act gat cag cca 1027Leu Ile Ala Ile Glu Lys Ala Leu Ala Thr Thr Phe Thr Asp Gln Pro

295 300 305act caa cag gga cag cgc cac gat ggg gat ctg gtg gtc aac aac ttg 1075Thr Gln Gln Gly Gln Arg His Asp Gly Asp Leu Val Val Asn Asn Leu310 315 320 325aag atc gcc cgc gat cac agg gac att gtg cac ggt atc tct ttc agc 1123Lys Ile Ala Arg Asp His Arg Asp Ile Val His Gly Ile Ser Phe Ser

330 335 340att ccc cgc ggt tcc cac atc gcg gtg gta ggt ccc agt ggc gct ggt 1171Ile Pro Arg Gly Ser His Ile Ala Val Val Gly Pro Ser Gly Ala Gly

345 350 355aaa tcc tct gtg gct cta gcg ttg tcc gga ctt tta gag ttt gat ggt 1219Lys Ser Ser Val Ala Leu Ala Leu Ser Gly Leu Leu Glu Phe Asp Gly

360 365 370gcg att tcc ctc ggc ggc cac aac tgt gag atg tta gat ctt cgc gcc 1267Ala Ile Ser Leu Gly Gly His Asn Cys Glu Met Leu Asp Leu Arg Ala

375 380 385tca gtc agt ttc gtg ccc caa tcc ccc acg ctg ttt agc gga agc atc 1315Ser Val Ser Phe Val Pro Gln Ser Pro Thr Leu Phe Ser Gly Ser Ile390 395 400 405aaa agc aat atc gat ctg gcg cgc acg ggt gtt gat tct gat cac atc 1363Lys Ser Asn Ile Asp Leu Ala Arg Thr Gly Val Asp Ser Asp His Ile

410 415 420cac gca gca ctt tta ggc gaa gaa ctc ccc gcg gac ctc aaa gtc ggt 1411His Ala Ala Leu Leu Gly Glu Glu Leu Pro Ala Asp Leu Lys Val Gly

425 430 435gaa acc ggc aaa ggt gtc tcc ggc ggc caa gca gca cgc att tcc att 1459Glu Thr Gly Lys Gly Val Ser Gly Gly Gln Ala Ala Arg Ile Ser Ile

440 445 450gcc cga ggt tta gta aag aat gct gcc gtg att gtt ctc gac gag gcg 1507Ala Arg Gly Leu Val Lys Asn Ala Ala Val Ile Val Leu Asp Glu Ala

455 460 465acc gca caa ctc gac tac acc aac gcc cgc cag gtt cga cat ctt gcc 1555Thr Ala Gln Leu Asp Tyr Thr Asn Ala Arg Gln Val Arg His Leu Ala470 475 480 485aaa tcc ctt gag tgc acg ttg gtt gag atc acc cac cgc cca tca gaa 1603Lys Ser Leu Glu Cys Thr Leu Val Glu Ile Thr His Arg Pro Ser Glu

490 495 500gcc ctc gat gca gac ttc atc att gtt tta gag gat ggc caa ttg acc 1651Ala Leu Asp Ala Asp Phe Ile Ile Val Leu Glu Asp Gly Gln Leu Thr

505 510 515atg atg gat aca ccc agc aac gtt tcc cag cac aat gcg ttt ttc cgc 1699Met Met Asp Thr Pro Ser Asn Val Ser Gln His Asn Ala Phe Phe Arg

520 525 530acc gct gtg atg gag gaa gaa caa tgatttcccg acttctccaa ttg 1746Thr Ala Val Met Glu Glu Glu Gln

535540<210>322<211>54l<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>322Met Arg Ser Leu Leu Arg Asp Ile Pro Ala Val Gly Trp Leu Ile Thr 151015 Ala Thr Ile Val Val Arg Thr Leu Val Val Ala Leu Val Ile Val Gly

20 25 30Ile Gly Leu Leu Ile Asp Val Pro Ser Pro Ala His Ser Ala Met Leu

35 40 45Trp Trp Val Leu Ala Gly Ala Thr Ala Ala Ala Ala Leu Leu Cys Ala

50 55 60Glu Ala Val Leu Pro Gln Arg Ile Arg Ala Arg Val Glu Arg Ser Trp 65 70 75 80Arg Arg Gln Leu Ala Ala Lys Asn Leu Glu Leu Asn Ser Ser Ser Ser

85 90 95Asp Asp Ala Gln Leu Ile Thr Leu Ala Thr Glu Ala Thr Ser Lys Ala

100 105 110Ser Thr Tyr Thr Val Met Phe Leu Gly Pro Tyr Phe Ala Val Phe Leu

115 120 125Ala Pro Leu Thr Val Ile Ala Val Val Gly Ala Ala Ile Ser Trp Pro

130 135 140Ile Ala Gly Ile Leu Cys Leu Gly Leu Cys Val Ile Pro Phe Val Ile145 150 155 160Ser Trp Ala Gln Arg Met Leu Lys Gly Ala Gly Ala Gly Tyr Gly Arg

165 170 175Ala Ser Gly Gln Leu Ala Gly Val Phe Leu Glu Ser Val Arg Thr Leu

180 185 190Gly Thr Thr Met Met Leu Asn Ala Ala Gly Gln Arg Arg Gln Ile Ile

195 200 205Thr Gln Arg Ala Glu Asn Met Arg Ser Gln Val Met Ser Leu Leu Tyr

210 215 220Arg Asn Gln Leu Met Ile Leu Val Thr Asp Gly Val Phe Gly Val Ala225 230 235 240Thr Thr Met Val Ala Ala Val Phe Ala Ile Gly Gly Phe Phe Ser Gly

245 250 255Ser Leu Thr Leu Gly Gln Ala Val Ala Leu Val Leu Leu Ala Arg Leu

260 265 270Leu Ile Asp Pro Ile Asn Arg Met Gly Arg Thr Phe Tyr Thr Gly Met

275 280 285Ala Gly Lys Pro Ser Leu Ile Ala Ile Glu Lys Ala Leu Ala Thr Thr

290 295 300Phe Thr Asp Gln Pro Thr Gln Gln Gly Gln Arg His Asp Gly Asp Leu305 310 315 320Val Val Asn Asn Leu Lys Ile Ala Arg Asp His Arg Asp Ile Val His

325 330 335Gly Ile Ser Phe Ser Ile Pro Arg Gly Ser His Ile Ala Val Val Gly

340 345 350Pro Ser Gly Ala Gly Lys Ser Ser Val Ala Leu Ala Leu Ser Gly Leu

355 360 365Leu Glu Phe Asp Gly Ala Ile Ser Leu Gly Gly His Asn Cys Glu Met

370 375 380Leu Asp Leu Arg Ala Ser Val Ser Phe Val Pro Gln Ser Pro Thr Leu385 390 395 400Phe Ser Gly Ser Ile Lys Ser Asn Ile Asp Leu Ala Arg Thr Gly Val

405 410 415Asp Ser Asp His Ile His Ala Ala Leu Leu Gly Glu Glu Leu Pro Ala

420 425 430Asp Leu Lys Val Gly Glu Thr Gly Lys Gly Val Ser Gly Gly Gln Ala

435 440 445Ala Arg Ile Ser Ile Ala Arg Gly Leu Val Lys Asn Ala Ala Val Ile

450 455 460Val Leu Asp Glu Ala Thr Ala Gln Leu Asp Tyr Thr Asn Ala Arg Gln465 470 475 480Val Arg His Leu Ala Lys Ser Leu Glu Cys Thr Leu Val Glu Ile Thr

485 490 495His Arg Pro Ser Glu Ala Leu Asp Ala Asp Phe Ile Ile Val Leu Glu

500 505 510Asp Gly Gln Leu Thr Met Met Asp Thr Pro Ser Asn Val Ser Gln His

515 520 525Asn Ala Phe Phe Arg Thr Ala Val Met Glu Glu Glu Gln

530535540<210>323<211>1527<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1504)<223>RXA02095<400>323ctctcttggt cctctcccca cccattttta agtactcaag acccttccaa cagaaaggat 60tactccccca acaggctcaa aaatactgaa aggctcacgc atg aaa act gag caa 115

Met Lys Thr Glu Gln

1 5tcc caa aaa gca caa tta gcc cct aag aaa gca cct gaa aag cca caa 163Ser Gln Lys Ala Gln Leu Ala Pro Lys Lys Ala Pro Glu Lys Pro Gln

10 15 20cgc atc cgc caa ctt att tcc gtg gcg tgg cag cga cct tgg ctc acc 211Arg Ile Arg Gln Leu Ile Ser Val Ala Trp Gln Arg Pro Trp Leu Thr

25 30 35tca ttc acc gta atc agc gct tta gct gca acg ttg ttt gaa ctt aca 259Ser Phe Thr Val Ile Ser Ala Leu Ala Ala Thr Leu Phe Glu Leu Thr

40 45 50ctt cct ctt ttg acc ggt ggc gcc atc gat atc gcg ctc gga aat acc 307Leu Pro Leu Leu Thr Gly Gly Ala Ile Asp Ile Ala Leu Gly Asn Thr

55 60 65gga gat act tta acc act gac ctg ctg gac cgg ttc act ccg agt gga 355Gly Asp Thr Leu Thr Thr Asp Leu Leu Asp Arg Phe Thr Pro Ser Gly 70 75 80 85tta agc gtg ttg acc agc gtc att gcc ctt atc gtg ctt ctc gcg ttg 403Leu Ser Val Leu Thr Ser Val Ile Ala Leu Ile Val Leu Leu Ala Leu

90 95 100ctt cgc tat gcc agt caa ttt gga cgg cga tac acc gca ggc aag ctc 451Leu Arg Tyr Ala Ser Gln Phe Gly Arg Arg Tyr Thr Ala Gly Lys Leu

105 110 115agc atg ggg gta cag cat gat gtc cgg ctt aaa acg atg cgc tca ttg 499Ser Met Gly Val Gln His Asp Val Arg Leu Lys Thr Met Arg Ser Leu

120 125 130cag aac ctc gat ggg cca ggt cag gac tct att cgc aca ggc caa gta 547Gln Asn Leu Asp Gly Pro Gly Gln Asp Ser Ile Arg Thr Gly Gln Val

135 140 145gtc agt cgg tcc att tcg gat atc aac atg gtg caa agc ctt gtg gcg 595Val Ser Arg Ser Ile Ser Asp Ile Asn Met Val Gln Ser Leu Val Ala150 155 160 165atg ttg ccg atg ttg atc gga aat gtg gtc aag ctt gtg ctc act ttg 643Met Leu Pro Met Leu Ile Gly Asn Val Val Lys Leu Val Leu Thr Leu

170 175 180gtg atc atg ctg gct att tcc ccg ccg ctg acc atc atc gct gca gtg 691Val Ile Met Leu Ala Ile Ser Pro Pro Leu Thr Ile Ile Ala Ala Val

185 190 195ttg gtg cct ttg ctg ttg tgg gcc gtg gcc tat tcg cga aaa gcg ctt 739Leu Val Pro Leu Leu Leu Trp Ala Val Ala Tyr Ser Arg Lys Ala Leu

200 205 210ttt gcg tcc acg tgg tcg gcc cag caa aag gct gcg gat ctg acc act 787Phe Ala Ser Thr Trp Ser Ala Gln Gln Lys Ala Ala Asp Leu Thr Thr

215 220 225cat gtg gaa gaa act gtc acg ggt atc cgc gtg gtc aag gca ttt gcg 835His Val Glu Glu Thr Mal Thr Gly Ile Arg Val Val Lys Ala Phe Ala230 235 240 245cag gaa gac cgc gag acc gac aaa ttg gatctc acc gca cgt gag tta 883Gln Glu Asp Arg Glu Thr Asp Lys Leu Asp Leu Thr Ala Arg Glu Leu

250 255 260ttt gcc cag cgc atg cgc act gca cgt ctg acg gca aag ttc atc ccc 931Phe Ala Gln Arg Met Arg Thr Ala Arg Leu Thr Ala Lys Phe Ile Pro

265 270 275atg gtt gag cag ctt ccg cag ctt gct ttg gtg gtc aac att gtt ggc 979Met Val Glu Gln Leu Pro Gln Leu Ala Leu Val Val Asn Ile Val Gly

280 285 290ggt ggc tat ttg gcc atg act ggt cac atc acg gtg ggc acg ttt gtg 1027Gly Gly Tyr Leu Ala Met Thr Gly His Ile Thr Val Gly Thr Phe Val

295 300 305gcg ttt tct tcc tat ctc act agc ttg tcg gcg gtg gct agg tcc ctg 1075Ala Phe Ser Ser Tyr Leu Thr Ser Leu Ser Ala Val Ala Arg Ser Leu310 315 320 325tcg ggc atg ctc atg cgc gtg cag ttg gcg ctg tct tct gtg gag cgc 1123Ser Gly Met Leu Met Arg Val Gln Leu Ala Leu Ser Ser Val Glu Arg

330 335 340atc ttt gaa gtc att gat ctt cag cct gaa cgc acc gat cct gca cac 1171Ile Phe Glu Val Ile Asp Leu Gln Pro Glu Arg Thr Asp Pro Ala His

345 350 355ccc ctg tca ctt ccc gac act ccc ctg ggt ctg tcg ttc aac aac gta 1219Pro Leu Ser Leu Pro Asp Thr Pro Leu Gly Leu Ser Phe Asn Asn Val

360 365 370gat ttc cgt ggg att ctc aac ggt ttt gag ctg ggt gtt cag gcc ggt 1267Asp Phe Arg Gly Ile Leu Asn Gly Phe Glu Leu Gly Val Gln Ala Gly

375 380 385gaa acc gtt gtg ttg gtg ggc cct cca ggt tca ggc aag acc atg gct 1315Glu Thr Val Val Leu Val Gly Pro Pro Gly Ser Gly Lys Thr Met Ala390395 400 405gtg cag ctt gct gga aac ttt tat caa cca gac agc ggc cac atc gcc 1363Val Gln Leu Ala Gly Asn Phe Tyr Gln Pro Asp Ser Gly His Ile Ala

410 415 420ttt gat agc aac ggc cat cgc act cgc ttc gac gac ctc acc cac agc 1411Phe Asp Ser Asn Gly His Arg Thr Arg Phe Asp Asp Leu Thr His Ser

425 430 435gat atc cgc agg aat ctc atc gcg gtt ttt gat gag ccg ttc ttg tac 1459Asp Ile Arg Arg Asn Leu Ile Ala Val Phe Asp Glu Pro Phe Leu Tyr

440 445 450tcc tcc tcc ata ccg cga gaa cat ctc gat ggg ttt gga tgt cag 1504Ser Ser Ser Ile Pro Arg Glu His Leu Asp Gly Phe Gly Cys Gln

455460465 tgatgagcag atcgaacacg cag 1527<210>324<211>468<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>324Met Lys Thr Glu Gln Ser Gln Lys Ala Gln Leu Ala Pro Lys Lys Ala 151015 Pro Glu Lys Pro Gln Arg Ile Arg Gln Leu Ile Ser Val Ala Trp Gln

20 25 30Arg Pro Trp Leu Thr Ser Phe Thr Val Ile Ser Ala Leu Ala Ala Thr

35 40 45Leu Phe Glu Leu Thr Leu Pro Leu Leu Thr Gly Gly Ala Ile Asp Ile

50 55 60Ala Leu Gly Asn Thr Gly Asp Thr Leu Thr Thr Asp Leu Leu Asp Arg 65 70 75 80Phe Thr Pro Ser Gly Leu Ser Val Leu Thr Ser Val Ile Ala Leu Ile

85 90 95Val Leu Leu Ala Leu Leu Arg Tyr Ala Ser Gln Phe Gly Arg Arg Tyr

100 105 110Thr Ala Gly Lys Leu Ser Met Gly Val Gln His AspVal Arg Leu Lys

115 120 125Thr Met Arg Ser Leu Gln Asn Leu Asp Gly Pro Gly Gln Asp Ser Ile

130 135 140Arg Thr Gly Gln Val Val Ser Arg Ser Ile Ser Asp Ile Asn Met Val145 150 155 160Gln Ser Leu Val Ala Met Leu Pro Met Leu Ile Gly Asn Val Val Lys

165 170 175Leu Val Leu Thr Leu Val Ile Met Leu Ala Ile Ser Pro Pro Leu Thr

180 185 190Ile Ile Ala Ala Val Leu Val Pro Leu Leu Leu Trp Ala Val Ala Tyr

195 200 205Ser Arg Lys Ala Leu Phe Ala Ser Thr Trp Ser Ala Gln Gln Lys Ala

210 215 220Ala Asp Leu Thr Thr His Val Glu Glu Thr Val Thr Gly Ile Arg Val225 230 235 240Val Lys Ala Phe Ala Gln Glu Asp Arg Glu Thr Asp Lys Leu Asp Leu

245 250 255Thr Ala Arg Glu Leu Phe Ala Gln Arg Met Arg Thr Ala Arg Leu Thr

260 265 270Ala Lys Phe Ile Pro Met Val Glu Gln Leu Pro Gln Leu Ala Leu Val

275 280 285Val Asn Ile Val Gly Gly Gly Tyr Leu Ala Met Thr Gly His Ile Thr

290 295 300Val Gly Thr Phe Val Ala Phe Ser Ser Tyr Leu Thr Ser Leu Ser Ala305 310 315 320Val Ala Arg Ser Leu Ser Gly Met Leu Met Arg Val Gln Leu Ala Leu

325 330 335Ser Ser Val Glu Arg Ile Phe Glu Val Ile Asp Leu Gln Pro Glu Arg

340 345 350Thr Asp Pro Ala His Pro Leu Ser Leu Pro Asp Thr Pro Leu Gly Leu

355 360 365Ser Phe Asn Asn Val Asp Phe Arg Gly Ile Leu Asn Gly Phe Glu Leu

370 375 380Gly Val Gln Ala Gly Glu Thr Val Val Leu Val Gly Pro Pro Gly Ser385 390 395 400Gly Lys Thr Met Ala Val Gln Leu Ala Gly Asn Phe Tyr Gln Pro Asp

405 410 415Ser Gly His Ile Ala Phe Asp Ser Asn Gly His Arg Thr Arg Phe Asp

420 425 430Asp Leu Thr His Ser Asp Ile Arg Arg Asn Leu Ile Ala Val Phe Asp

435 440 445Glu Pro Phe Leu Tyr Ser Ser Ser Ile Pro Arg Glu His Leu Asp Gly

450455460 Phe Gly Cys Gln465<210>325<211>905<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (882)<223>RXA02225<400>325caa act gag gag cgc ttt ggc gca gcg gct gat gaa gcc ttg gca atc 48Gln Thr Glu Glu Arg Phe Gly Ala Ala Ala Asp Glu Ala Leu Ala Ile 151015 atg ttg aag gaa gct cgt ctg cag tcg ttg ctg act ttt gtg cgc caa 96Met Leu Lys Glu Ala Arg Leu Gln Ser Leu Leu Thr Phe Val Arg Gln

20 25 30ctt gtc cca gcg gtg ttt tct gtg ggt ctt ttg gct tat gcg tca ctg 144Leu Val Pro Ala Val Phe Ser Val Gly Leu Leu Ala Tyr Ala Ser Leu

35 40 45ttg gct ttt gac ggt gac ata act ggt ggt gag atg atc tcg gtg acg 192Leu Ala Phe Asp Gly Asp Ile Thr Gly Gly Glu Met Ile Ser Val Thr

5055 60ttg ctg gtg cca cct tcg ttg act gtg ttg ggt gtg tcg ctt ggc atg 240Leu Leu Val Pro Pro Ser Leu Thr Val Leu Gly Val Ser Leu Gly Met 65 70 75 80atg aca gag att tgg gct agg gga cag gct tcg aca aaa agg gtc caa 288Met Thr Glu Ile Trp Ala Arg Gly Gln Ala Ser Thr Lys Arg Val Gln

85 90 95aac tta gtc act gaa ctg gat aag gcg gcc gct gag cca cga cct cag 336Asn Leu Val Thr Glu Leu Asp Lys Ala Ala Ala Glu Pro Arg Pro Gln

100 105 110cct gcc acc ttt gaa ttt gaa gag ggg atc acg gtg tgg gat cct tcg 384Pro Ala Thr Phe Glu Phe Glu Glu Gly Ile Thr Val Trp Asp Pro Ser

115 120 125aca cct gag gca cgc gat gtg att gat cgg gag ttg gag gcg ctt cag 432Thr Pro Glu Ala Arg Asp Val Ile Asp Arg Glu Leu Glu Ala Leu Gln

130 135 140gtt cgc gaa gat gtc att gtg gct cct cac cgc gtc agc gtg ttt gaa 480Val Arg Glu Asp Val Ile Val Ala Pro His Arg Val Ser Val Phe Glu145 150 155 160ggt gtg ctg aag gat aat ttg aat ccg atg ggc act atc gca ccg gag 528Gly Val Leu Lys Asp Asn Leu Asn Pro Met Gly Thr Ile Ala Pro Glu

165 170 175atg ctg cgc gct gct ctt cat gct gca agt tgt gag gac atc ttg agc 576Met Leu Arg Ala Ala Leu His Ala Ala Ser Cys Glu Asp Ile Leu Ser

180 185 190cga ttg ggt gct gat ctg aac atg ccg ggg gag ttt gag ctt cca gat 624Arg Leu Gly Ala Asp Leu Asn Met Pro Gly Glu Phe Glu Leu Pro Asp

195 200 205acc ttg atc ggc gag gcc gga ttg aat ctc tcc ggt ggc caa cgc cag 672Thr Leu IleGly Glu Ala Gly Leu Asn Leu Ser Gly Gly Gln Arg Gln

210 215 220agg att gct ttg gca cga ttc ttg gct gtt gat cct gag gtg ctc att 720Arg Ile Ala Leu Ala Arg Phe Leu Ala Val Asp Pro Glu Val Leu Ile225 230 235 240ttg gat gaa ccg acc acg ggg ttg gat gcg gtg acc ctg gat gaa gtg 768Leu Asp Glu Pro Thr Thr Gly Leu Asp Ala Val Thr Leu Asp Glu Val

245 250 255gca cat cgc gtc gaa aag ctt cgt cga ggc cgg aaa acc gtc gtc att 816Ala His Arg Val Glu Lys Leu Arg Arg Gly Arg Lys Thr Val Val Ile

260 265 270acg tcg aac ccg acg tgg cac ggc gtc gca aag cag atg caa tct gat 864Thr Ser Asn Pro Thr Trp His Gly Val Ala Lys Gln Met Gln Ser Asp

275 280 285ttt tcg gaa ggg gtg aag tagatggcgc agcatgagcg cgt 905Phe Ser Glu Gly Val Lys

290<210>326<211>294<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>326Gln Thr Glu Glu Arg Phe Gly Ala Ala Ala Asp Glu Ala Leu Ala Ile 151015 Met Leu Lys Glu Ala Arg Leu Gln Ser Leu Leu Thr Phe Val Arg Gln

20 25 30Leu Val Pro Ala Val Phe Ser Val Gly Leu Leu Ala Tyr Ala Ser Leu

35 40 45Leu Ala Phe Asp Gly Asp Ile Thr Gly Gly Glu Met Ile Ser Val Thr

50 55 60Leu Leu Val Pro Pro Ser Leu Thr Val Leu Gly Val Ser Leu Gly Met 65 70 75 80Met Thr Glu Ile Trp Ala Arg Gly Gln Ala Ser Thr Lys Arg Val Gln

85 90 95Asn Leu Val Thr Glu Leu Asp Lys Ala Ala Ala Glu Pro Arg Pro Gln

100 105 110Pro Ala Thr Phe Glu Phe Glu Glu Gly Ile Thr Val Trp Asp Pro Ser

115 120 125Thr Pro Glu Ala Arg Asp Val Ile Asp Arg Glu Leu Glu Ala Leu Gln

130 135 140Val Arg Glu Asp Val Ile Val Ala Pro His Arg Val Ser Val Phe Glu145 150 155 160Gly Val Leu Lys Asp Asn Leu Asn Pro Met Gly Thr Ile Ala Pro Glu

165 170 175Met Leu Arg Ala Ala Leu His Ala Ala Ser Cys Glu Asp Ile Leu Ser

180 185 190Arg Leu Gly Ala Asp Leu Asn Met Pro Gly Glu Phe Glu Leu Pro Asp

195 200 205Thr Leu Ile Gly Glu Ala Gly Leu Asn Leu Ser Gly Gly Gln Arg Gln

210 215 220Arg Ile Ala Leu Ala Arg Phe Leu Ala Val Asp Pro Glu Val Leu Ile225 230 235 240Leu Asp Glu Pro Thr Thr Gly Leu Asp Ala Val Thr Leu Asp Glu Val

245 250 255Ala His Arg Val Glu Lys Leu Arg Arg Gly Arg Lys Thr Val Val Ile

260 265 270Thr Ser Asn Pro Thr Trp His Gly Val Ala Lys Gln Met Gln Ser Asp

275 280 285Phe Ser Glu Gly Val Lys

290<210>327<211>1050<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1027)<223>RXA02253<400>327<327tgaggacatt tcccaagtga aaggcttcgg cccgaaactt gcggaggctg tctatgaagg 60tcttcacgcg tcaaaataag tagatcgcta ggatgtaacc atg att caa tcc act 115

Met Ile Gln Ser Thr

1 5ggg gtc acg cac act gat aag tct gca caa gaa aat cct gtg aag tac 163Gly Val Thr His Thr Asp Lys Ser Ala Gln Glu Asn Pro Val Lys Tyr

10 15 20agg gac aat ttc aca cct gtc atc atc acc ggt atg tca ggc gca ggt 211Arg Asp Asn Phe Thr Pro Val Ile Ile Thr Gly Met Ser Gly Ala Gly

25 30 35ctg agc aca gca gcc cga gtc ctc gaa gac ttg ggt tgg tat gtg gcg 259Leu Ser Thr Ala Ala Arg Val Leu Glu Asp Leu Gly Trp Tyr Val Ala

40 45 50cac aat att cca cca cag atc atc etg gaa tta att gat atg tgc gct 307His Asn Ile Pro Pro Gln Ile Ile Leu Glu Leu Ile Asp Met Cys Ala

55 60 65cgg gaa gat tct ccc gtc gac aaa gtt gca gtc gtg tgc gat gtg cgc 355Arg Glu Asp Ser Pro Val Asp Lys Val Ala Val Val Cys Asp Val Arg 70 75 80 85tcc cgt gaa ttc cgc gga agc ctc acc cag gtt gtt tca gag ctg cgt 403Ser Arg Glu Phe Arg Gly Ser Leu Thr Gln Val Val Ser Glu Leu Arg

90 95 100gat aag cag ctc gat ccc acg gtg tta ttt ctg gaa gca cgc gat gag 451Asp Lys Gln Leu Asp Pro Thr Val Leu Phe Leu Glu Ala Arg Asp Glu

105 110 115gtg ctg atc aag cga ttc gat aat gtg cgc cgc acc cat cct ttg cag 499Val Leu Ile Lys Arg Phe Asp Asn Val Arg Arg Thr His Pro Leu Gln

120 125 130ggc agc caa accctt cag gtg ggt att gaa cgt gaa cga acc gtg ctg 547Gly Ser Gln Thr Leu Gln Val Gly Ile Glu Arg Glu Arg Thr Val Leu

135 140 145tct cct gtg aag gaa gac gct tca gtg gtc atc gat acc tcg gat ctg 595Ser Pro Val Lys Glu Asp Ala Ser Val Val Ile Asp Thr Ser Asp Leu150 155 160 165tcc gtg cat gat ttg cgc cgc gcc atc gaa tcc tcg ttt agg aca atc 643Ser Val His Asp Leu Arg Arg Ala Ile Glu Ser Ser Phe Arg Thr Ile

170 175 180gcc acg cgc acc cag cac gtc acc att gaa tca ttc ggt ttc aaa cac 691Ala Thr Arg Thr Gln His Val Thr Ile Glu Ser Phe Gly Phe Lys His

185 190 195ggc tca cca cgc gac gcc gac ttt gtt gtg gac gtg cgt ttc ttg ccg 739Gly Ser Pro Arg Asp Ala Asp Phe Val Val Asp Val Arg Phe Leu Pro

200 205 210aac cca ttc tgg gtt cca gag ctg cgc cca ttt agg gga gtg gac aag 787Asn Pro Phe Trp Val Pro Glu Leu Arg Pro Phe Arg Gly Val Asp Lys

215 220 225cca gta tct gac tat gtg ctc tcc caa aaa ggc gca gaa gaa ttt ttg 835Pro Val Ser Asp Tyr Val Leu Ser Gln Lys Gly Ala Glu Glu Phe Leu230 235 240 245aac aac ttt gtg gac atg ctc aaa gac atg ctt ccg gga tac cgc cac 883Asn Asn Phe Val Asp Met Leu Lys Asp Met Leu Pro Gly Tyr Arg His

250 255 260gaa gga aaa aac ttc atc aca atc ggt gtc ggc tgc acc ggt gga cac 931Glu Gly Lys Asn Phe Ile Thr Ile Gly Val Gly Cys Thr Gly Gly His

265 270 275cac aga tca gtt gcg gtg tct gaa gaa cta gcc aaa aga atc gca gat 979His Arg Ser Val Ala Val Ser Glu Glu Leu Ala Lys Arg Ile AlaAsp

280 285 290cag acc acg ctc gac gtg tct gta gta cac cgc gat att aac cgc cac 1027Gln Thr Thr Leu Asp Val Ser Val Val His Arg Asp Ile Asn Arg His

295300305 taggaaaggg gccaactaat tga 1050<210>328<211>309<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>328Met Ile Gln Ser Thr Gly Val Thr His Thr Asp Lys Ser Ala Gln Glu 151015 Asn Pro Val Lys Tyr Arg Asp Asn Phe Thr Pro Val Ile Ile Thr Gly

20 25 30Met Ser Gly Ala Gly Leu Ser Thr Ala Ala Arg Val Leu Glu Asp Leu

35 40 45Gly Trp Tyr Val Ala His Asn Ile Pro Pro Gln Ile Ile Leu Glu Leu

50 55 60Ile Asp Met Cys Ala Arg Glu Asp Ser Pro Val Asp Lys Val Ala Val 65 70 75 80Val Cys Asp Val Arg Ser Arg Glu Phe Arg Gly Ser Leu Thr Gln Val

85 90 95Val Ser Glu Leu Arg Asp Lys Gln Leu Asp Pro Thr Val Leu Phe Leu

100 105 110Glu Ala Arg Asp Glu Val Leu Ile Lys Arg Phe Asp Asn Val Arg Arg

115 120 125Thr His Pro Leu Gln Gly Ser Gln Thr Leu Gln Val Gly Ile Glu Arg

130 135 140Glu Arg Thr Val Leu Ser Pro Val Lys Glu Asp Ala Ser Val Val Ile145 150 155 160Asp Thr Ser Asp Leu Ser Val His Asp Leu Arg Arg Ala Ile Glu Ser

165 170 175Ser Phe Arg Thr Ile Ala Thr Arg Thr Gln His Val Thr Ile Glu Ser

180 185 190Phe Gly Phe Lys His Gly Ser Pro Arg Asp Ala Asp Phe Val Val Asp

195 200 205Val Arg Phe Leu Pro Asn Pro Phe Trp Val Pro Glu Leu Arg Pro Phe

210 215 220Arg Gly Val Asp Lys Pro Val Ser Asp Tyr Val Leu Ser Gln Lys Gly225 230 235 240Ala Glu Glu Phe Leu Asn Asn Phe Val Asp Met Leu Lys Asp Met Leu

245 250 255Pro Gly Tyr Arg His Glu Gly Lys Asn Phe Ile Thr Ile Gly Val Gly

260 265 270Cys Thr Gly Gly His His Arg Ser Val Ala Val Ser Glu Glu Leu Ala

275 280 285Lys Arg Ile Ala Asp Gln Thr Thr Leu Asp Val Ser Val Val His Arg

290295300 Asp Ile Asn Arg His305<210>329<211>558<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (535)<223>RXN01881<400>329accggccctg cggcctcaac cgccgaccag cgcggcgcac acattttgac tgtttcataa 60taaagacaaa cttaagtatc ggagtcgaag aaaaaccaca atg gcc aat ctg att 115

Met Ala Asn Leu Ile

1 5aat ctc gag aac gtc tcc aaa acc tgg gga tta aaa acg ctt ctc gac 163Asn Leu Glu Asn Val Ser Lys Thr Trp Gly Leu Lys Thr Leu Leu Asp

10 15 20ggt gtc tcc tta ggt gtt caa acc ggc gac cgc att ggc gtc gtc ggc 211Gly Val Ser Leu Gly Val Gln Thr Gly Asp Arg Ile Gly Val Val Gly

25 3035ctc aat ggt ggc gga aaa acc acc ctg ctg gaa gta ctt act ggc atc 259Leu Asn Gly Gly Gly Lys Thr Thr Leu Leu Glu Val Leu Thr Gly Ile

40 45 50gaa aag ccg gat cag ggc cgt gtg tct cac aac tct gac ctg cgc atg 307Glu Lys Pro Asp Gln Gly Arg Val Ser His Asn Ser Asp Leu Arg Met

55 60 65gct gtg gtg acg cag cgt gct gaa ctc aat gat gac gac acc gtc gct 355Ala Val Val Thr Gln Arg Ala Glu Leu Asn Asp Asp Asp Thr Val Ala 70 75 80 85gac gtg gtg ctt gga cct ttg ggt ttg gaa gtt ttc gaa tgg gca tca 403Asp Val Val Leu Gly Pro Leu Gly Leu Glu Val Phe Glu Trp Ala Ser

90 95 100aac gcc acg gtg cgc gac gtc ctc ggt ggc ttg ggc att gtc gat ctt 451Asn Ala Thr Val Arg Asp Val Leu Gly Gly Leu Gly Ile Val Asp Leu

105 110 115ggc ctt gac acc aag gtg ggc aaa cct ttt ccg gtg ggc gaa gcg ccg 499Gly Leu Asp Thr Lys Val Gly Lys Pro Phe Pro Val Gly Glu Ala Pro

120 125 130acg cac caa cct ggc cgc cgc gct ggt tcg cga cct tgacctgatc 545Thr His Gln Pro Gly Arg Arg Ala Gly Ser Arg Pro

135140145 gtgctcgacg agc 558<210>330<211>145<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>330Met Ala Asn Leu Ile Asn Leu Glu Asn Val Ser Lys Thr Trp Gly Leu 151015 Lys Thr Leu Leu Asp Gly Val Ser Leu Gly Val Gln Thr Gly Asp Arg

20 25 30Ile Gly Val Val Gly Leu Asn Gly Gly Gly Lys Thr Thr Leu Leu Glu

35 40 45Val Leu Thr Gly Ile Glu Lys Pro Asp Gln Gly Arg Val Ser His Asn

50 55 60Ser Asp Leu Arg Met Ala Val Val Thr Gln Arg Ala Glu Leu Asn Asp 65 70 75 80Asp Asp Thr Val Ala Asp Val Val Leu Gly Pro Leu Gly Leu Glu Val

85 90 95Phe Glu Trp Ala Ser Asn Ala Thr Val Arg Asp Val Leu Gly Gly Leu

100 105 110Gly Ile Val Asp Leu Gly Leu Asp Thr Lys Val Gly Lys Pro Phe Pro

115 120 125Val Gly Glu Ala Pro Thr His Gln Pro Gly Arg Arg Ala Gly Ser Arg

130135140 Pro145<210>331<211>564<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<541)>FRXA01881<400>331accggccctg cggcctcaac cgccgaccag cgcggcgcac acattttgac tgtttcataa 60taaagacaaa cttaagtatc ggagtcgaag aaaaaccaca atg gcc aat ctg att 115

Met Ala Asn Leu Ile

1 5aat ctc gag aac gtc tcc aaa acc tgg gga tta aaa acg ctt ctc gac 163Asn Leu Glu Asn Val Ser Lys Thr Trp Gly Leu Lys Thr Leu Leu Asp

10 15 20ggt gtc tcc tta ggt gtt caa acc ggc gac cgc att ggc gtc gtc ggc 211Gly Val Ser Leu Gly Val Gln Thr Gly Asp Arg Ile Gly Val Val Gly

25 30 35ctc aat ggt ggc gga aaa acc acc ctg ctg gaa gta ctt act ggc atc 259Leu Asn Gly Gly Gly Lys Thr Thr Leu Leu Glu Val Leu Thr Gly Ile

40 45 50gaa aag ccg gat cag ggc cgt gtg tct cac aac tct gac ctg cgc atg 307Glu Lys Pro Asp Gln Gly Arg Val Ser His Asn Ser Asp Leu Arg Met

55 60 65gct gtg gtg acg cag cgt gct gaa ctc aat gat gac gac acc gtc gct 355Ala Val Val Thr Gln Arg Ala Glu Leu Asn Asp Asp Asp Thr Val Ala 70 75 80 85gac gtg gtg ctt gga cct ttg ggt ttg gaa gtt ttc gaa tgg gca tca 403Asp Val Val Leu Gly Pro Leu Gly Leu Glu Val Phe Glu Trp Ala Ser

90 95 100aac gcc acg gtg cgc gac gtc ctc ggt ggc ttg ggc att gtc gat ctt 451Asn Ala Thr Val Arg Asp Val Leu Gly Gly Leu Gly Ile Val Asp Leu

105 110 115ggc ctt gac acc aag gtg ggg caa acc ttt tcc ggt ggg cga agc gcc 499Gly Leu Asp Thr Lys Val Gly Gln Thr Phe Ser Gly Gly Arg Ser Ala

120 125 130gac gca cca acc tgg ccg ccg cgc tgg ttc gcg acc ttg acc 541Asp Ala Pro Thr Trp Pro Pro Arg Trp Phe Ala Thr Leu Thr

135140145 tgatcgtgct cgacgagccc acc 564<210>332<211>147<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>332Met Ala Asn Leu Ile Asn Leu Glu Asn Val Ser Lys Thr Trp Gly Leu 151015 Lys Thr Leu Leu Asp Gly Val Ser Leu Gly Val Gln Thr Gly Asp Arg

20 25 30Ile Gly Val Val Gly Leu Asn Gly Gly Gly Lys Thr Thr Leu Leu Glu

35 40 45Val Leu Thr Gly Ile Glu Lys Pro Asp Gln Gly Arg Val Ser His Asn

50 55 60Ser Asp Leu Arg Met Ala Val Val Thr Gln Arg Ala Glu Leu Asn Asp 65 70 75 80Asp Asp Thr Val Ala Asp Val Val Leu Gly Pro Leu Gly Leu Glu Val

85 90 95Phe Glu Trp Ala Ser Asn Ala Thr Val Arg Asp Val Leu Gly Gly Leu

100 105 110Gly Ile Val Asp Leu Gly Leu Asp Thr Lys Val Gly Gln Thr Phe Ser

115 120 125Gly Gly Arg Ser Ala Asp Ala Pro Thr Trp Pro Pro Arg Trp Phe Ala

130135140 Thr Leu Thr145<210>333<211>813<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).)

Met Ser Leu Ile Glu

1 5atg cga aat att gtc aag acc tac aac att gga tct gaa ggt gaa ctc 163Met Arg Asn Ile Val Lys Thr Tyr Asn Ile Gly Ser Glu Gly Glu Leu

10 15 20acc gtg ttg cac ggt gtg gat ttc cat gtg gac cgt ggc gaa ttc gtg 211Thr Val Leu His Gly Val Asp Phe His Val Asp Arg Gly Glu Phe Val

25 30 35tcg gtt gtg ggt acg tcc ggc tca ggt aaa tca acg atg atg aac atc 259Ser Val Val Gly Thr Ser Gly Ser Gly Lys Ser Thr Met Met Asn Ile

40 45 50att ggg ttg ttg gat aag cca act gat ggc acg tac acc ttg gat ggc 307Ile Gly Leu Leu Asp Lys Pro Thr Asp Gly Thr Tyr Thr Leu Asp Gly

55 60 65gtg gat gtg ttg gat atc agc gat gat gct ttg gcg agc cac cgc gct 355Val Asp Val Leu Asp Ile Ser Asp Asp Ala Leu Ala Ser His Arg Ala 70 75 80 85aaa tcg att ggt ttt gtg ttt cag aac ttc aat ctg att ggc cgg atc 403Lys Ser Ile Gly Phe Val Phe Gln Asn Phe Asn Leu Ile Gly Arg Ile

90 95 100gat gcg ttg aag aat gtg gaa atg ccc atg atg tat gcg ggc att ccg 451Asp Ala Leu Lys Asn Val Glu Met Pro Met Met Tyr Ala Gly Ile Pro

105 110 115gct aag cag cgg aga agt cgt gcg gtt gaa tta ttg gaa atg gtc ggg 499Ala Lys Gln Arg Arg Ser Arg Ala Val Glu Leu Leu Glu Met Val Gly

120 125 130atg ggt gag cgt ctc aac cat gag ccc aat gag ctt tcg ggt ggt cag 547Met Gly Glu Arg Leu Asn His Glu Pro Asn Glu Leu Ser Gly Gly Gln

135 140 145aag cag cgc gtg gcc att gct cgc gcg ttg gcg aac gat cct gag atc 595Lys Gln Arg Val Ala Ile Ala Arg Ala Leu Ala Asn Asp Pro Glu Ile150 155 160 165att ctt gct gat gaa cca act ggt gcg ttg gat tct gca acg ggc cgg 643Ile Leu Ala Asp Glu Pro Thr Gly Ala Leu Asp Ser Ala Thr Gly Arg

170 175 180atg gtg atg gat att ttc cac cag ctc aac aag gag cag ggc aaa acc 691Met Val Met Asp Ile Phe His Gln Leu Asn Lys Glu Gln Gly Lys Thr

185 190 195atc gtg ttt att act cac aac cct gag ctt gct gat gaa tct gat cgg 739Ile Val Phe Ile Thr His Asn Pro Glu Leu Ala Asp Glu Ser Asp Arg

200 205 210gtg gtc acc atg gtt gac ggg cgc atc att ggg tct gag gtg aaa cac 787Val Val Thr Met Val Asp Gly Arg Ile Ile Gly Ser Glu Val Lys His

215220225 tca tgagccttgc agaatcaatt ctt 813Ser230<210>334<211>230<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>334Met Ser Leu Ile Glu Met Arg Asn Ile Val Lys Thr Tyr Asn Ile Gly 151015 Ser Glu Gly Glu Leu Thr Val Leu His Gly Val Asp Phe His Val Asp

20 25 30Arg Gly Glu Phe Val Ser Val Val Gly Thr Ser Gly Ser Gly Lys Ser

35 40 45Thr Met Met Asn Ile Ile Gly Leu Leu Asp Lys Pro Thr Asp Gly Thr

50 55 60Tyr Thr Leu Asp Gly Val Asp Val Leu Asp Ile Ser Asp Asp Ala Leu 65 70 75 80Ala Ser His Arg Ala Lys Ser Ile Gly Phe Val Phe Gln Asn Phe Asn

85 90 95Leu Ile Gly Arg Ile Asp Ala Leu Lys Asn Val Glu Met Pro Met Met

100 105 110Tyr Ala Gly Ile Pro Ala Lys Gln Arg Arg Ser Arg Ala Val Glu Leu

115 120 125Leu Glu Met Val Gly Met Gly Glu Arg Leu Asn His Glu Pro Asn Glu

130 135 140Leu Ser Gly Gly Gln Lys Gln Arg Val Ala Ile Ala Arg Ala Leu Ala145 150 155 160Asn Asp Pro Glu Ile Ile Leu Ala Asp Glu Pro Thr Gly Ala Leu Asp

165 170 175Ser Ala Thr Gly Arg Met Val Met Asp Ile Phe His Gln Leu Asn Lys

180 185 190Glu Gln Gly Lys Thr Ile Val Phe Ile Thr His Asn Pro Glu Leu Ala

195 200 205Asp Glu Ser Asp Arg Val Val Thr Met Val Asp Gly Arg Ile Ile Gly

210215220 Ser Glu Val Lys His Ser 225230<210>335<211>1008<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (985)<223>RXN00733<400>335acggcgaggt tgtcggtatt ggaacgcaca cgaatttgct gaacacgtgc ggtacctacc 60gtgaaattgt tgaatcccaa gagactgcgc aggcgcaatc atg agt aat act gca 115

Met Ser Asn Thr Ala

1 5ggc ccc cgc ggg cgt tcc cat cag gca gac gcc gcg ccg aat caa aag 163Gly Pro Arg Gly Arg Ser His Gln Ala Asp Ala Ala Pro Asn Gln Lys

10 15 20gca cag aat ttc gga cca tct gcc aaa agg ctt ttc gga att cta ggc 211Ala Gln Asn Phe Gly Pro Ser Ala Lys Arg Leu Phe Gly Ile Leu Gly

25 30 35cat gac cgt aac acc tta att ttt gtt atc ttc cta gcc gtc ctg agc 259His Asp Arg Asn Thr Leu Ile Phe Val Ile Phe Leu Ala Val Leu Ser

40 45 50gtt gga ctt acc gtc ttg ggc cca tgg ttg ctg ggt aaa gcc acc aac 307Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu Gly Lys Ala Thr Asn

55 60 65gtg gtg ttt gaa gga ttc cta tct aag cgc atg ccg gct ggt gcg tca 355Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met Pro Ala Gly Ala Ser 70 75 80 85aag gaa gat atc atc gcg cag ttg cag gct gca ggt aaa cat aat cag 403Lys Glu Asp Ile Ile Ala Gln Leu Gln Ala Ala Gly Lys His Asn Gln

90 95 100gct tcc atg atg gaa gac atg aac ctt gtt cca ggc tca ggc att gat 451Ala Ser Met Met Glu Asp Met Asn Leu Val Pro Gly Ser Gly Ile Asp

105 110 115ttt gaa aaa tta gcc atg atc ctc gga ctg gtg atc ggt gct tat ctc 499Phe Glu Lys Leu Ala Met Ile Leu Gly Leu Val Ile Gly Ala Tyr Leu

120 125 130atc ggt agc ctg ttg tcg ttg ttc cag gcg cgg atg ctc aac cgc atc 547Ile Gly Ser Leu Leu Ser Leu Phe Gln Ala Arg Met Leu Asn Arg Ile

135 140 145gtg caa agt gcc atg cac cgg ctg cgc atg gag gtg gag gaa aaa atc 595Val Gln Ser Ala Met His Arg Leu Arg Met Glu Val Glu Glu Lys Ile150 155 160 165cac cgc cta ccg ctg agc tat ttc gat tcc atc aaa cgt ggt gat ctg 643His Arg Leu Pro Leu Ser Tyr Phe Asp Ser Ile Lys Arg Gly Asp Leu

170 175 180ctt agc cgt gtg acc aac gat gtg gat aat atc ggt caa tcc ctg caa 691Leu Ser Arg Val Thr Asn Asp Val Asp Asn Ile Gly Gln Ser Leu Gln

185 190 195caa acc ttg tca cag gcg atc act tcc cta ctg acc gtc atc ggt gtg 739Gln Thr Leu Ser Gln Ala Ile Thr Ser Leu Leu Thr Val Ile Gly Val

200 205 210ttg gtg atg atg ttt atc atc tcc cca ctg ctc gca ctc gtg gcg ctg 787Leu Val Met Met Phe Ile Ile Ser Pro Leu Leu Ala Leu Val Ala Leu

215 220 225gta tcc att ccg gtc acc atc gtg gtc act gtg gtg gtt gcg agc cgt 835Val Ser Ile Pro Val Thr Ile Val Val Thr Val Val Val Ala Ser Arg230 235 240 245tcc cag aaa ctc ttt gcg gaa cag tgg aag cag acc ggt att ttg aat 883Ser Gln Lys Leu Phe Ala Glu Gln Trp Lys Gln Thr Gly Ile Leu Asn

250 255 260gcg cgc ctg gag gaa acc tac tct ggc cac gcc gtg gtt aag gtt ttc 931Ala Arg Leu Glu Glu Thr Tyr Ser Gly His Ala Val Val Lys Val Phe

265 270 275gga cac caa aag gat gtt caa gaa gca ttc gag gaa gaa aat caa gct 979Gly His Gln Lys Asp Val Gln Glu Ala Phe Glu Glu Glu Asn Gln Ala

280 285 290tgt gta taaggccagc tttggtgccc agt 1008Cys Val

295<210>336<211>295<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>336Met Ser Asn Thr Ala Gly Pro Arg Gly Arg Ser His Gln Ala Asp Ala 151015 Ala Pro Asn Gln Lys Ala Gln Asn Phe Gly Pro Ser Ala Lys Arg Leu

20 25 30Phe Gly Ile Leu Gly His Asp Arg Asn Thr Leu Ile Phe Val Ile Phe

35 40 45Leu Ala Val Leu Ser Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu

50 55 60Gly Lys Ala Thr Asn Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met 65 70 75 80Pro Ala Gly Ala Ser Lys Glu Asp Ile Ile Ala Gln Leu Gln Ala Ala

85 90 95Gly Lys His Asn Gln Ala Ser Met Met Glu Asp Met Asn Leu Val Pro

100 105 110Gly Ser Gly Ile Asp Phe Glu Lys Leu Ala Met Ile Leu Gly Leu Val

115 120 125Ile Gly Ala Tyr Leu Ile Gly Ser Leu Leu Ser Leu Phe Gln Ala Arg

130 135 140Met Leu Asn Arg Ile Val Gln Ser Ala Met His Arg Leu Arg Met Glu145 150 155 160Val Glu Glu Lys Ile His Arg Leu Pro Leu Ser Tyr Phe Asp Ser Ile

165 170 175Lys Arg Gly Asp Leu Leu Ser Arg Val Thr Asn Asp Val Asp Asn Ile

180 185190Gly Gln Ser Leu Gln Gln Thr Leu Ser Gln Ala Ile Thr Ser Leu Leu

195 200 205Thr Val Ile Gly Val Leu Val Met Met Phe Ile Ile Ser Pro Leu Leu

210 215 220Ala Leu Val Ala Leu Val Ser Ile Pro Val Thr Ile Val Val Thr Val225 230 235 240Val Val Ala Ser Arg Ser Gln Lys Leu Phe Ala Glu Gln Trp Lys Gln

245 250 255Thr Gly Ile Leu Asn Ala Arg Leu Glu Glu Thr Tyr Ser Gly His Ala

260 265 270Val Val Lys Val Phe Gly His Gln Lys Asp Val Gln Glu Ala Phe Glu

275 280 285Glu Glu Asn Gln Ala Cys Val

290295<210>337<211>508<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (508)<223>FRXA00733<400>337acggcgaggt tgtcggtatt ggaacgcaca cgaatttgct gaacacgtgc ggtacctacc 60gtgaaattgt tgaatcccaa gagactgcgc aggcgcaatc atg agt aat act gca 115

Met Ser Asn Thr Ala

1 5ggc ccc cgc ggg cgt tcc cat cag gca gac gcc gcg ccg aat caa aag 163Gly Pro Arg Gly Arg Ser His Gln Ala Asp Ala Ala Pro Asn Gln Lys

10 15 20gca cag aat ttc gga cca tct gcc aaa agg ctt ttc gga att cta ggc 211Ala Gln Asn Phe Gly Pro Ser Ala Lys Arg Leu Phe Gly Ile Leu Gly

25 30 35cat gac cgt aac acc tta att ttt gtt atc ttc cta gcc gtc ctg agc 259His Asp Arg Asn Thr Leu Ile Phe Val Ile Phe Leu Ala Val Leu Ser

40 45 50gtt gga ctt acc gtc ttg ggc cca tgg ttg ctg ggt aaa gcc acc aac 307Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu Gly Lys Ala Thr Asn

55 60 65gtg gtg ttt gaa gga ttc cta tct aag cgc atg ccg gct ggt gcg tca 355Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met Pro Ala Gly Ala Ser 70 75 80 85aag gaa gat atc atc gcg cag ttg cag gct gca ggt aaa cat aat cag 403Lys Glu Asp Ile Ile Ala Gln Leu Gln Ala Ala Gly Lys His Asn Gln

90 95 100gct tcc atg atg gaa gac atg aac ctt gtt cca ggc tca ggc att gat 451Ala Ser Met Met Glu Asp Met Asn Leu Val Pro Gly Ser Gly Ile Asp

105 110 115ttt gaa aaa tta gcc atg atc ctc gga ctg gtg atc ggt gct tat ctc 499Phe Glu Lys Leu Ala Met Ile Leu Gly Leu Val Ile Gly Ala Tyr Leu

120 125 130att cgt agc 508Ile Arg Ser

135<210>338<211>136<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>338Met Ser Asn Thr Ala Gly Pro Arg Gly Arg Ser His Gln Ala Asp Ala 151015 Ala Pro Asn Gln Lys Ala Gln Asn Phe Gly Pro Ser Ala Lys Arg Leu

20 25 30Phe Gly Ile Leu Gly His Asp Arg Asn Thr Leu Ile Phe Val Ile Phe

35 40 45Leu Ala Val Leu Ser Val Gly Leu Thr Val Leu Gly Pro Trp Leu Leu

50 55 60Gly Lys Ala Thr Asn Val Val Phe Glu Gly Phe Leu Ser Lys Arg Met 65 7075 80Pro Ala Gly Ala Ser Lys Glu Asp Ile Ile Ala Gln Leu Gln Ala Ala

85 90 95Gly Lys His Asn Gln Ala Ser Met Met Glu Asp Met Asn Leu Val Pro

100 105 110Gly Ser Gly Ile Asp Phe Glu Lys Leu Ala Met Ile Leu Gly Leu Val

115 120 125Ile Gly Ala Tyr Leu Ile Arg Ser

130135<210>339<211>692<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (669)<223>RXA00735<400>339ggt ccc acc ggt gcg ggc aag acc aca ttg gtg aat ctg atc atg cgt 48Gly Pro Thr Gly Ala Gly Lys Thr Thr Leu Val Asn Leu Ile Met Arg 151015 ttc tac gac atc aac agc ggt tcc atc act ctt ggt gaa aca gca caa 96Phe Tyr Asp Ile Asn Ser Gly Ser Ile Thr Leu Gly Glu Thr Ala Gln

20 25 30gac gcc gtg gat atc cgc acc atg gct aga gaa gat ctg cga tca cga 144Asp Ala Val Asp Ile Arg Thr Met Ala Arg Glu Asp Leu Arg Ser Arg

35 40 45acc ggc atg gtg ttg cag gat acg tgg ctg ttt gcc gga acc atc agg 192Thr Gly Met Val Leu Gln Asp Thr Trp Leu Phe Ala Gly Thr Ile Arg

50 55 60gat aac att ctt tac ggt aga cct gaa gca act gag gaa gaa atg ctt 240Asp Asn Ile Leu Tyr Gly Arg Pro Glu Ala Thr Glu Glu Glu Met Leu 65 70 75 80gct gcg tcc aag gcc gcc tac gtg gat cgt ttt gtc cgt tcc ctg cca 288Ala Ala Ser Lys Ala Ala Tyr Val Asp Arg Phe Val Arg Ser Leu Pro

85 90 95gaa ggc tac gac acc gta ctt gat gat gaa gcc atg aac cta tcg gtg 336GluGly Tyr Asp Thr Val Leu Asp Asp Glu Ala Met Asn Leu Ser Val

100 105 110ggt gaa cgc cag ctg atc acc atc gcg cgt gca ttc ttg gct aat ccc 384Gly Glu Arg Gln Leu Ile Thr Ile Ala Arg Ala Phe Leu Ala Asn Pro

115 120 125cga ctg ctg att ctg gat gaa gcc acc tca tcg gtg gat acg cgt acc 432Arg Leu Leu Ile Leu Asp Glu Ala Thr Ser Ser Val Asp Thr Arg Thr

130 135 140gaa ttg ttg att cag cgc gcc atg tcc aag ctg cgc caa gac cgc acc 480Glu Leu Leu Ile Gln Arg Ala Met Ser Lys Leu Arg Gln Asp Arg Thr145 150 155 160gcc ttc gtc atc gcg cac cgg ttg tcc acg attcgt gat gcc aac ctg 528Ala Phe Val Ile Ala His Arg Leu Ser Thr Ile Arg Asp Ala Asn Leu

165 170 175att ttg atg atg aaa gac ggc gag atc gtg gag cag ggc aat cac cgt 576Ile Leu Met Met Lys Asp Gly Glu Ile Val Glu Gln Gly Ash His Arg

180 185 190gag ttg atg gcc ctg gag ggc gca tat tgg gag ttg tat aac tcc caa 624Glu Leu Met Ala Leu Glu Gly Ala Tyr Trp Glu Leu Tyr Asn Ser Gln

195 200 205ttc aac gcc ccc gcg aaa gaa gaa tta cag gct gac gga gat cac 669Phe Asn Ala Pro Ala Lys Glu Glu Leu Gln Ala Asp Gly Asp His

210215220 tgatgatttc ttcttaggct ttc 692<210>340<211>223<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>340Gly Pro Thr Gly Ala Gly Lys Thr Thr Leu Val Asn Leu Ile Met Arg 151015 Phe Tyr Asp Ile Asn Ser Gly Ser Ile Thr Leu Gly Glu Thr Ala Gln

20 25 30Asp Ala Val Asp Ile Arg Thr Met Ala Arg Glu Asp Leu Arg Ser Arg

35 40 45Thr Gly Met Val Leu Gln Asp Thr Trp Leu Phe Ala Gly Thr Ile Arg

50 55 60Asp Asn Ile Leu Tyr Gly Arg Pro Glu Ala Thr Glu Glu Glu Met Leu 65 70 75 80Ala Ala Ser Lys Ala Ala Tyr Val Asp Arg Phe Val Arg Ser Leu Pro

85 90 95Glu Gly Tyr Asp Thr Val Leu Asp Asp Glu Ala Met Asn Leu Ser Val

100 105 110Gly Glu Arg Gln Leu Ile Thr Ile Ala Arg Ala Phe Leu Ala Asn Pro

115 120 125Arg Leu Leu Ile Leu Asp Glu Ala Thr Ser Ser Val Asp Thr Arg Thr

130 135 140Glu Leu Leu Ile Gln Arg Ala Met Ser Lys Leu Arg Gln Asp Arg Thr145 150 155 160Ala Phe Val Ile Ala His Arg Leu Ser Thr Ile Arg Asp Ala Asn Leu

165 170 175Ile Leu Met Met Lys Asp Gly Glu Ile Val Glu Gln Gly Asn His Arg

180 185 190Glu Leu Met Ala Leu Glu Gly Ala Tyr Trp Glu Leu Tyr Asn Ser Gln

195 200 205Phe Asn Ala Pro Ala Lys Glu Glu Leu Gln Ala Asp Gly Asp His

210215220<210>341<211>1986<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1963)<223>RXA00878<400>341cgagattagg tccgcttcag ttgtggtggc tccgaatctg atgaacaatg atcattccta 60attcatttac atctttatca aagagagcca ccacctacta atg cga ctt ctt ggt 115

Met Arg Leu Leu Gly

1 5cga att tta aaa acc acg tct gcg ctt tgg ccc tac tat ctc gga att 163Arg Ile Leu Lys Thr Thr Ser Ala Leu Trp Pro Tyr Tyr Leu Gly Ile

10 15 20atc gtc gta tcc att gtg atc gcg gcg ttg tcg ctg ctg tcg ccg ttt 211Ile Val Val Ser Ile Val Ile Ala Ala Leu Ser Leu Leu Ser Pro Phe

25 30 35att ctc cgc gaa gca aca gat tcc att gtt tct gca gta acc gga tct 259Ile Leu Arg Glu Ala Thr Asp Ser Ile Val Ser Ala Val Thr Gly Ser

40 45 50aac acc gtc gat gca gtt act cgc act att att ttc tta gct tta gcc 307Asn Thr Val Asp Ala Val Thr Arg Thr Ile Ile Phe Leu Ala Leu Ala

55 60 65ctg ttt gtc gca agc ttc ctc aat acg gtg atg acc aac atc ggt ggc 355Leu Phe Val Ala Ser Phe Leu Asn Thr Val Met Thr Asn Ile Gly Gly 70 75 80 85tac atc ggt gat gtc atg gca tct cgt atg cgc cag att ctg gcc acg 403Tyr Ile Gly Asp Val Met Ala Ser Arg Met Arg Gln Ile Leu Ala Thr

90 95 100cgc tat tac gca aag ctg ttg gcg ctg cct cag aag tat ttt gat aat 451Arg Tyr Tyr Ala Lys Leu Leu Ala Leu Pro Gln Lys Tyr Phe Asp Asn

105 110 115cag gtc acc ggc acc atc atc gcc cgc ctt gat cga tca atc aac ggc 499Gln Val Thr Gly Thr Ile Ile Ala Arg Leu Asp Arg Ser Ile Asn Gly

120 125 130atc acg cag ttc atg cag agc ttc tcc aac aac ttc ttc ccc atg ctc 547Ile Thr Gln Phe Met Gln Ser Phe Ser Asn Asn Phe Phe Pro Met Leu

135140 145atc acc atg gtg gca gtg ctg att att tcc gcg att ttc tac tgg cct 595Ile Thr Met Val Ala Val Leu Ile Ile Ser Ala Ile Phe Tyr Trp Pro150 155 160 165ctg gca att ctg ctg gcc atg ttg ttc ccg att tac atg tgg ctg acg 643Leu Ala Ile Leu Leu Ala Met Leu Phe Pro Ile Tyr Met Trp Leu Thr

170 175 180gcg ttg aca tcg aaa cgc tgg cag aaa tat gag ggc gag aaa aac cat 691Ala Leu Thr Ser Lys Arg Trp Gln Lys Tyr Glu Gly Glu Lys Asn His

185 190 195gaa atc gac gtg gct aac ggc cgc ttc gct gag gtt gtc ggc cag gtc 739Glu Ile Asp Val Ala Asn Gly Arg Phe Ala Glu Val Val Gly Gln Val

200 205 210aag gtt gtt aaa tca ttc gtc gca gag acc cgc gag ctg gct gat ttc 787Lys Val Val Lys Ser Phe Val Ala Glu Thr Arg Glu Leu Ala Asp Phe

215 220 225ggt ggg cgt tac ggc aaa aca gta gcg att acc cgg ccg caa tcc ggt 835Gly Gly Arg Tyr Gly Lys Thr Val Ala Ile Thr Arg Pro Gln Ser Gly230 235 240 245tgg tgg cac cgc atg gat act ctc cgt ggc gcg gca cta aat atc atc 883Trp Trp His Arg Met Asp Thr Leu Arg Gly Ala Ala Leu Asn Ile Ile

250 255 260ttc ctg gcc att cac ctg ctg att ttc tac cgc acc ttg cac ggc cat 931Phe Leu Ala Ile His Leu Leu Ile Phe Tyr Arg Thr Leu His Gly His

265 270 275ttc acc atc ggc gac atg gtc atg ctc atc cag ctt gtc acc atg gcg 979Phe Thr Ile Gly Asp Met Val Met Leu Ile Gln Leu Val Thr Met Ala

280 285 290cag caa ccg gtg tac atg atg agc tac atc gtc gac tcc gcg cag cgc 1027Gln Gln Pro Val Tyr Met Met Ser Tyr Ile Val Asp Ser Ala Gln Arg

295 300 305gcc atc gcc ggc tcc cgc gac tac ttc gag gtc atg gcg cag cag gtc 1075Ala Ile Ala Gly Ser Arg Asp Tyr Phe Glu Val Met Ala Gln Gln Val310 315 320 325gag ccc acc gcc aat aag gag ctt gtc gac gcc acc ctc gcc tca gac 1123Glu Pro Thr Ala Asn Lys Glu Leu Val Asp Ala Thr Leu Ala Ser Asp

330 335 340act cca cgc atc agt gtg ggc acg ccc gcc gcg ctg ccc gct gga gaa 1171Thr Pro Arg Ile Ser Val Gly Thr Pro Ala Ala Leu Pro Ala Gly Glu

345 350 355cca gcg atg gaa ttc aaa aac gtc acc ttc gcc tac gaa gaa ggc aag 1219Pro Ala Met Glu Phe Lys Asn Val Thr Phe Ala Tyr Glu Glu Gly Lys

360 365 370ccg gtt att tcc gac gtg tcc att acc gcc cgc cac ggc gag cgc atc 1267Pro Val Ile Ser Asp Val Ser Ile Thr Ala Arg His Gly Glu Arg Ile

375 380 385gcg ttg gtc ggt gaa tcc ggc ggc ggt aaa tcc acc ctg gtc aac ctt 1315Ala Leu Val Gly Glu Ser Gly Gly Gly Lys Ser Thr Leu Val Asn Leu390 395 400 405ctg tta ggt ctg tac aaa cca aac agc ggc agc ctt gca gta tgt ggc 1363Leu Leu Gly Leu Tyr Lys Pro Asn Ser Gly Ser Leu Ala Val Cys Gly

410 415 420gtg gat gtt aaa gat ctg act tcc gag gaa ctt cgc gca tcc gtg ggt 1411Val Asp Val Lys Asp Leu Thr Ser Glu Glu Leu Arg Ala Ser Val Gly

425 430 435gtg gtc ttc cag gac gcc agc ttg ttc tct gga tct att gca gaa aac 1459Val Val Phe Gln Asp Ala Ser Leu Phe Ser Gly Ser Ile Ala Glu Asn

440 445 450atc gcc tac ggt cgc cca ggt gcc acc cgc gaa gag atc atc gaa gtg 1507Ile Ala Tyr Gly Arg Pro Gly Ala Thr Arg Glu Glu Ile Ile Glu Val

455 460 465gct aag aaa gcc aac gca cat gag ttc att tcc gcc ttc cct gaa gga 1555Ala Lys Lys Ala Asn Ala His Glu Phe Ile Ser Ala Phe Pro Glu Gly470 475 480 485tat gaa acc gtc gtc ggt gaa cgc gga ctc aaa ctt tct ggt ggc cag 1603Tyr Glu Thr Val Val Gly Glu Arg Gly Leu Lys Leu Ser Gly Gly Gln

490 495 500aag cag cgc gtc tct gtg gca cgg gcc atg ctt aaa gat gcc cca ctt 1651Lys Gln Arg Val Ser Val Ala Arg Ala Met Leu Lys Asp Ala Pro Leu

505 510 515ctt gtt ctc gat gaa gcc acc tct gca ctg gat acc aag tct gag cag 1699Leu Val Leu Asp Glu Ala Thr Ser Ala Leu Asp Thr Lys Ser Glu Gln

520 525 530gca gtc caa gcc ggt ttg gaa cag ctg atg gaa aac cgc acc acc tta 1747Ala Val Gln Ala Gly Leu Glu Gln Leu Met Glu Asn Arg Thr Thr Leu

535 540 545atg atc gcc cac cgc ctg tcc acc atc gca ggc gtc gat acc atc gtg 1795Met Ile Ala His Arg Leu Ser Thr Ile Ala Gly Val Asp Thr Ile Val550 555 560 565acc atc caa aac gga cgg gtt gaa gag gtc gga tct cct acc gag ctc 1843Thr Ile Gln Asn Gly Arg Val Glu Glu Val Gly Ser Pro Thr Glu Leu

570 575 580gca gtc tca ggc ggt atc tat tcc gaa ctg ctg cgc ctg acc aac tcc 1891Ala Val Ser Gly Gly Ile Tyr Ser Glu Leu Leu Arg Leu Thr Asn Ser

585 590 595aca gca gaa gcc gac cgg gag cgt ctg cgc gcc ttt ggt ttc act ggc 1939Thr Ala Glu Ala Asp Arg Glu Arg Leu Arg Ala Phe Gly Phe Thr Gly

600 605 610gat gca cca gct gaa gaa gag gac tagccccgcg aaagaacaat ccc 1986Asp Ala Pro Ala Glu Glu Glu Asp

615620<210>342<211>621<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>342Met Arg Leu Leu Gly Arg Ile Leu Lys Thr Thr Ser Ala Leu Trp Pro 151015 Tyr Tyr Leu Gly Ile Ile Val Val Ser Ile Val Ile Ala Ala Leu Ser

20 25 30Leu Leu Ser Pro Phe Ile Leu Arg Glu Ala Thr Asp Ser Ile Val Ser

35 40 45Ala Val Thr Gly Ser Asn Thr Val Asp Ala Val Thr Arg Thr Ile Ile

50 55 60Phe Leu Ala Leu Ala Leu Phe Val Ala Ser Phe Leu Asn Thr Val Met 65 70 75 80Thr Asn Ile Gly Gly Tyr Ile Gly Asp Val Met Ala Ser Arg Met Arg

85 90 95Gln Ile Leu Ala Thr Arg Tyr Tyr Ala Lys Leu Leu Ala Leu Pro Gln

100 105 110Lys Tyr Phe Asp Asn Gln Val Thr Gly Thr Ile Ile Ala Arg Leu Asp

115 120 125Arg Ser Ile Asn Gly Ile Thr Gln Phe Met Gln Ser Phe Ser Asn Asn

130 135 140Phe Phe Pro Met Leu Ile Thr Met Val Ala Val Leu Ile Ile Ser Ala145 150 155 160Ile Phe Tyr Trp Pro Leu Ala Ile Leu Leu Ala Met Leu Phe Pro Ile

165 170 175Tyr Met Trp Leu Thr Ala Leu Thr Ser Lys Arg Trp Gln Lys Tyr Glu

180185 190Gly Glu Lys Asn His Glu Ile Asp Val Ala Asn Gly Arg Phe Ala Glu

195 200 205Val Val Gly Gln Val Lys Val Val Lys Ser Phe Val Ala Glu Thr Arg

210 215 220Glu Leu Ala Asp Phe Gly Gly Arg Tyr Gly Lys Thr Val Ala Ile Thr225 230 235 240Arg Pro Gln Ser Gly Trp Trp His Arg Met Asp Thr Leu Arg Gly Ala

245 250 255Ala Leu Asn Ile Ile Phe Leu Ala Ile His Leu Leu Ile Phe Tyr Arg

260 265 270Thr Leu His Gly His Phe Thr Ile Gly Asp Met Val Met Leu Ile Gln

275 280 285Leu Val Thr Met Ala Gln Gln Pro Val Tyr Met Met Ser Tyr Ile Val

290 295 300Asp Ser Ala Gln Arg Ala Ile Ala Gly Ser Arg Asp Tyr Phe Glu Val305 310 315 320Met Ala Gln Gln Val Glu Pro Thr Ala Asn Lys Glu Leu Val Asp Ala

325 330 335Thr Leu Ala Ser Asp Thr Pro Arg Ile Ser Val Gly Thr Pro Ala Ala

340 345 350Leu Pro Ala Gly Glu Pro Ala Met Glu Phe Lys Asn Val Thr Phe Ala

355 360 365Tyr Glu Glu Gly Lys Pro Val Ile Ser Asp Val Ser Ile Thr Ala Arg

370 375 380His Gly Glu Arg Ile Ala Leu Val Gly Glu Ser Gly Gly Gly Lys Ser385 390 395 400Thr Leu Val Asn Leu Leu Leu Gly Leu Tyr Lys Pro Asn Ser Gly Ser

405410 415Leu Ala Val Cys Gly Val Asp Val Lys Asp Leu Thr Ser Glu Glu Leu

420 425 430Arg Ala Ser Val Gly Val Val Phe Gln Asp Ala Ser Leu Phe Ser Gly

435 440 445Ser Ile Ala Glu Asn Ile Ala Tyr Gly Arg Pro Gly Ala Thr Arg Glu

450 455 460Glu Ile Ile Glu Val Ala Lys Lys Ala Asn Ala His Glu Phe Ile Ser465 470 475 480Ala Phe Pro Glu Gly Tyr Glu Thr Val Val Gly Glu Arg Gly Leu Lys

485 490 495Leu Ser Gly Gly Gln Lys Gln Arg Val Ser Val Ala Arg Ala Met Leu

500 505 510Lys Asp Ala Pro Leu Leu Val Leu Asp Glu Ala Thr Ser Ala Leu Asp

515 520 525Thr Lys Ser Glu Gln Ala Val Gln Ala Gly Leu Glu Gln Leu Met Glu

530 535 540Asn Arg Thr Thr Leu Met Ile Ala His Arg Leu Ser Thr Ile Ala Gly545 550 555 560Val Asp Thr Ile Val Thr Ile Gln Asn Gly Arg Val Glu Glu Val Gly

565 570 575Ser Pro Thr Glu Leu Ala Val Ser Gly Gly Ile Tyr Ser Glu Leu Leu

580 585 590Arg Leu Thr Asn Ser Thr Ala Glu Ala Asp Arg Glu Arg Leu Arg Ala

595 600 605Phe Gly Phe Thr Gly Asp Ala Pro Ala Glu Glu Glu Asp

610615620<210>343<211>1713<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1690)<223>RXN01191<400>343cgctgctttc acgcaactga aaccgcaccg gatcaagtta tttggggttg ttctttgtgg 60cgtgttggtg gccgtcgcgg ggttggtagg gccctgggcg gtg ggt gga ctc gtc 115

Val Gly Gly Leu Val

1 5gat aag ctc ctt gca acc ccg agc atg cgc gac gtt gta gtg ttc gcg 163Asp Lys Leu Leu Ala Thr Pro Ser Met Arg Asp Val Val Val Phe Ala

10 15 20ctg ctt atc gtg gct ggc ggc gtt gtt tcg agc ctg ggc acg tgg tgg 211Leu Leu Ile Val Ala Gly Gly Val Val Ser Ser Leu Gly Thr Trp Trp

25 30 35ggc agc gcg ctg atg gcg cgc gcg ttg gag ccg gcg atc gcg ggg ctg 259Gly Ser Ala Leu Met Ala Arg Ala Leu Glu Pro Ala Ile Ala Gly Leu

40 45 50cgc gag gat gtg ttg cgc gcg gcg gtg agt ttg gat gcg aac acg att 307Arg Glu Asp Val Leu Arg Ala Ala Val Ser Leu Asp Ala Asn Thr Ile

55 60 65gaa acg gcg ggg cgc ggc gac gtg att tcg cgt atc gcg gat gat tcg 355Glu Thr Ala Gly Arg Gly Asp Val Ile Ser Arg Ile Ala Asp Asp Ser 70 75 80 85cgg gag gtg tcc act gcg gcg agc acc gtg gtg ccg ctg atg gtg cag 403Arg Glu Val Ser Thr Ala Ala Ser Thr Val Val Pro Leu Met Val Gln

90 95 100gcg ggc ttt acc gtg gtg att tcc gcg ttt ggc atg gcg gcg gtt gat 451Ala Gly Phe Thr Val Val Ile Ser Ala Phe Gly Met Ala Ala Val Asp

105 110 115tgg cgc ctc ggc ctt gtc ggt ttg gtc gcg atc ccg ctg tat tgg acc 499Trp Arg Leu Gly Leu Val Gly Leu Val Ala Ile Pro Leu Tyr Trp Thr

120125 130acg ttg cgc gtc tat tta ccc cgc tca ggt ccg ctt tat acg cgt gag 547Thr Leu Arg Val Tyr Leu Pro Arg Ser Gly Pro Leu Tyr Thr Arg Glu

135 140 145cgc gag gcc ttt ggg gtg cgc acg cag cgg ctt gtc ggc gca gtc gaa 595Arg Glu Ala Phe Gly Val Arg Thr Gln Arg Leu Val Gly Ala Val Glu150 155 160 165ggc gcg gaa acc ttg cgc gct ttc cgc gca gaa gat aca gaa tta aag 643Gly Ala Glu Thr Leu Arg Ala Phe Arg Ala Glu Asp Thr Glu Leu Lys

170 175 180cgt atc gac gca gcc tcc ggc gaa gcc cgc gac att tcc att tct gtt 691Arg Ile Asp Ala Ala Ser Gly Glu Ala Arg Asp Ile Ser Ile Ser Val

185 190 195ttc agg ttc ctc aca tgg gca ttt tcc cgc aac aac cgc gcg gaa tgc 739Phe Arg Phe Leu Thr Trp Ala Phe Ser Arg Asn Asn Arg Ala Glu Cys

200 205 210atc acc ctc gtg ctc atc ttg ggc acc ggc ttt tac ctg gtc aac atc 787Ile Thr Leu Val Leu Ile Leu Gly Thr Gly Phe Tyr Leu Val Asn Ile

215 220 225gat ctg gtc acc gtc ggc gca gtc tca acc gcc gca ctg atc ttc cac 835Asp Leu Val Thr Val Gly Ala Val Ser Thr Ala Ala Leu Ile Phe His230 235 240 245cga ctc ttc ggt cca atc ggc acg ctc gtg ggc atg ttc tcc gac atc 883Arg Leu Phe Gly Pro Ile Gly Thr Leu Val Gly Met Phe Ser Asp Ile

250 255 260caa tcc gcc agc gca tcg ctg atc cgc atg gtg ggc gtt att aac gcg 931Gln Ser Ala Ser Ala Ser Leu Ile Arg Met Val Gly Val Ile Asn Ala

265 270 275gca tcg aac cag gtc agc ggc acc tcg ccg gcg tct gcc agc acc gct 979Ala Ser Asn Gln Val Ser Gly Thr Ser Pro Ala Ser Ala Ser Thr Ala

280 285 290tta acg ctt ttc gac gtc tcc cac cac tat cac act gca ccc gtc atc 1027Leu Thr Leu Phe Asp Val Ser His His Tyr His Thr Ala Pro Val Ile

295 300 305aag aat gca tcc gtg cag ctg gaa cca ggg gaa cac atc gcc att gtg 1075Lys Asn Ala Ser Val Gln Leu Glu Pro Gly Glu His Ile Ala Ile Val310 315 320 325ggt gcg acc ggc gct ggt aaa agc acg ctc gcc ctc att gcg gca ggc 1123Gly Ala Thr Gly Ala Gly Lys Ser Thr Leu Ala Leu Ile Ala Ala Gly

330 335 340ctg ctc agc cca act tcc ggg cag gtg gct ctc ggc gga tcg agt ttt 1171Leu Leu Ser Pro Thr Ser Gly Gln Val Ala Leu Gly Gly Ser Ser Phe

345 350 355tct aac gtc gaa ccg gaa gca ttg cgc cag aag atc gcg atg gtc agc 1219Ser Asn Val Glu Pro Glu Ala Leu Arg Gln Lys Ile Ala Met Val Ser

360 365 370caa gaa atc cac tgc ttc cga gga tct gtt tta gat aat ctt cgt atc 1267Gln Glu Ile His Cys Phe Arg Gly Ser Val Leu Asp Asn Leu Arg Ile

375 380 385gca cgc ccc gaa gcc acc gat gcg gac atc cac gcc gtt ctc gcc gat 1315Ala Arg Pro Glu Ala Thr Asp Ala Asp Ile His Ala Val Leu Ala Asp390 395 400 405att ggt gat tcc tgg ttg gag cgc tta ccg caa ggc ata gac acc atc 1363Ile Gly Asp Ser Trp Leu Glu Arg Leu Pro Gln Gly Ile Asp Thr Ile

410 415 420gtg ggt gat ggc gct ttc cgt tta acc tct gtg gaa aac cag atc atg 1411Val Gly Asp Gly Ala Phe Arg Leu Thr Ser Val Glu Asn Gln Ile Met

425430 435gcg ctt gct cgc gta cat ttg gcc gac cta gca atc gtc atc ctt gat 1459Ala Leu Ala Arg Val His Leu Ala Asp Leu Ala Ile Val Ile Leu Asp

440 445 450gaa gca acg gct gaa tca ggc tct gat cat gca aaa cag ctt gaa gat 1507Glu Ala Thr Ala Glu Ser Gly Ser Asp His Ala Lys Gln Leu Glu Asp

455 460 465gca gcc ctt aaa gtc act gaa aac aga tca gcc atc atc gtg gct cac 1555Ala Ala Leu Lys Val Thr Glu Asn Arg Ser Ala Ile Ile Val Ala His470 475 480 485cgc ctc aac caa gcg aaa acc gcc gat cgc atc atc gtc atg gac tcc 1603Arg Leu Asn Gln Ala Lys Thr Ala Asp Arg Ile Ile Val Met Asp Ser

490 495 500gga gaa atc ata gaa tct gga acc cat gaa gag ctt cga gcg atc ggc 1651Gly Glu Ile Ile Glu Ser Gly Thr His Glu Glu Leu Arg Ala Ile Gly

505 510 515ggc cga tat gaa caa ctg tgg act gcg tgg tct gcg cgc taattagcca 1700Gly Arg Tyr Glu Gln Leu Trp Thr Ala Trp Ser Ala Arg

520525530 cccaagacca cgc 1713<210>344<211>530<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>344Val Gly Gly Leu Val Asp Lys Leu Leu Ala Thr Pro Ser Met Arg Asp 151015 Val Val Val Phe Ala Leu Leu Ile Val Ala Gly Gly Val Val Ser Ser

20 25 30Leu Gly Thr Trp Trp Gly Ser Ala Leu Met Ala Arg Ala Leu Glu Pro

35 40 45Ala Ile Ala Gly Leu Arg Glu Asp Val Leu Arg Ala Ala Val Ser Leu

50 55 60Asp Ala Asn Thr Ile Glu Thr Ala Gly Arg Gly Asp Val Ile Ser Arg 65 7075 80Ile Ala Asp Asp Ser Arg Glu Val Ser Thr Ala Ala Ser Thr Val Val

85 90 95Pro Leu Met Val Gln Ala Gly Phe Thr Val Val Ile Ser Ala Phe Gly

100 105 110Met Ala Ala Val Asp Trp Arg Leu Gly Leu Val Gly Leu Val Ala Ile

115 120 125Pro Leu Tyr Trp Thr Thr Leu Arg Val Tyr Leu Pro Arg Ser Gly Pro

130 135 140Leu Tyr Thr Arg Glu Arg Glu Ala Phe Gly Val Arg Thr Gln Arg Leu145 150 155 160Val Gly Ala Val Glu Gly Ala Glu Thr Leu Arg Ala Phe Arg Ala Glu

165 170 175Asp Thr Glu Leu Lys Arg Ile Asp Ala Ala Ser Gly Glu Ala Arg Asp

180 185 190Ile Ser Ile Ser Val Phe Arg Phe Leu Thr Trp Ala Phe Ser Arg Asn

195 200 205Asn Arg Ala Glu Cys Ile Thr Leu Val Leu Ile Leu Gly Thr Gly Phe

210 215 220Tyr Leu Val Asn Ile Asp Leu Val Thr Val Gly Ala Val Ser Thr Ala225 230 235 240Ala Leu Ile Phe His Arg Leu Phe Gly Pro Ile Gly Thr Leu Val Gly

245 250 255Met Phe Ser Asp Ile Gln Ser Ala Ser Ala Ser Leu Ile Arg Met Val

260 265 270Gly Val Ile Asn Ala Ala Ser Asn Gln Val Ser Gly Thr Ser Pro Ala

275 280 285Ser Ala Ser Thr Ala Leu Thr Leu Phe Asp Val Ser His His Tyr His

290 295 300Thr Ala Pro Val Ile Lys Asn Ala Ser Val Gln Leu Glu Pro Gly Glu305 310 315 320His Ile Ala Ile Val Gly Ala Thr Gly Ala Gly Lys Ser Thr Leu Ala

325 330 335Leu Ile Ala Ala Gly Leu Leu Ser Pro Thr Ser Gly Gln Val Ala Leu

340 345 350Gly Gly Ser Ser Phe Ser Asn Val Glu Pro Glu Ala Leu Arg Gln Lys

355 360 365Ile Ala Met Val Ser Gln Glu Ile His Cys Phe Arg Gly Ser Val Leu

370 375 380Asp Asn Leu Arg Ile Ala Arg Pro Glu Ala Thr Asp Ala Asp Ile His385 390 395 400Ala Val Leu Ala Asp Ile Gly Asp Ser Trp Leu Glu Arg Leu Pro Gln

405 410 415Gly Ile Asp Thr Ile Val Gly Asp Gly Ala Phe Arg Leu Thr Ser Val

420 425 430Glu Asn Gln Ile Met Ala Leu Ala Arg Val His Leu Ala Asp Leu Ala

435 440 445Ile Val Ile Leu Asp Glu Ala Thr Ala Glu Ser Gly Ser Asp His Ala

450 455 460Lys Gln Leu Glu Asp Ala Ala Leu Lys Val Thr Glu Asn Arg Ser Ala465 470 475 480Ile Ile Val Ala His Arg Leu Asn Gln Ala Lys Thr Ala Asp Arg Ile

485 490 495Ile Val Met Asp Ser Gly Glu Ile Ile Glu Ser Gly Thr His Glu Glu

500 505 510Leu Arg Ala Ile Gly Gly Arg Tyr Glu Gln Leu Trp Thr Ala Trp Ser

515 520 525Ala Arg

530<210>345<211>1430<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (1407)<223>FRXA01191<400>345gtg agt ttg gat gcg aac acg att gaa acg gcg ggg cgc ggc gac gtg 48Val Ser Leu Asp Ala Asn Thr Ile Glu Thr Ala Gly Arg Gly Asp Val 151015 att tcg cgt atc gcg gat gat tcg cgg gag gtg tcc act gcg gcg agc 96Ile Ser Arg Ile Ala Asp Asp Ser Arg Glu Val Ser Thr Ala Ala Ser

20 25 30acc gtg gtg ccg ctg atg gtg cag gcg ggc ttt acc gtg gtg att tcc 144Thr Val Val Pro Leu Met Val Gln Ala Gly Phe Thr Val Val Ile Ser

35 40 45gcg ttt ggc atg gcg gcg gtt gat tgg cgc ctc ggc ctt gtc ggt ttg 192Ala Phe Gly Met Ala Ala Val Asp Trp Arg Leu Gly Leu Val Gly Leu

50 55 60gtc gcg atc ccg ctg tat tgg acc acg ttg cgc gtc tat tta ccc cgc 240Val Ala Ile Pro Leu Tyr Trp Thr Thr Leu Arg Val Tyr Leu Pro Arg 65 70 75 80tca ggt ccg ctt tat acg cgt gag cgc gag gcc ttt ggg gtg cgc acg 288Ser Gly Pro Leu Tyr Thr Arg Glu Arg Glu Ala Phe Gly Val Arg Thr

85 90 95cag cgg ctt gtc ggc gca gtc gaa ggc gcg gaa acc ttg cgc gct ttc 336Gln Arg Leu Val Gly Ala Val Glu Gly Ala Glu Thr Leu Arg Ala Phe

100 105 110cgc gca gaa gat aca gaa tta aag cgt atc gac gca gcc tcc ggc gaa 384Arg Ala Glu Asp Thr Glu Leu Lys Arg Ile Asp Ala Ala Ser Gly Glu

115 120 125gcc cgc gac att tcc att tct gtt ttc agg ttc ctc aca tgg gca ttt 432Ala Arg Asp Ile Ser Ile Ser Val Phe Arg Phe Leu Thr Trp Ala Phe

130 135 140tcc cgc aac aac cgc gcg gaa tgc atc acc ctc gtg ctc atc ttg ggc 480Ser Arg Asn Asn Arg Ala Glu Cys Ile Thr Leu Val Leu Ile Leu Gly145 150 155 160acc ggc ttt tac ctg gtc aac atc gat ctg gtc acc gtc ggc gca gtc 528Thr Gly Phe Tyr Leu Val Asn Ile Asp Leu Val Thr Val Gly Ala Val

165 170 175tca acc gcc gca ctg atc ttc cac cga ctc ttc ggt cca atc ggc acg 576Ser Thr Ala Ala Leu Ile Phe His Arg Leu Phe Gly Pro Ile Gly Thr

180 185 190ctc gtg ggc atg ttc tcc gac atc caa tcc gcc agc gca tcg ctg atc 624Leu Val Gly Met Phe Ser Asp Ile Gln Ser Ala Ser Ala Ser Leu Ile

195 200 205cgc atg gtg ggc gtt att aac gcg gca tcg aac cag gtc agc ggc acc 672Arg Met Val Gly Val Ile Asn Ala Ala Ser Asn Gln Val Ser Gly Thr

210 215 220tcg ccg gcg tct gcc agc acc gct tta acg ctt ttc gac gtc tcc cac 720Ser Pro Ala Ser Ala Ser Thr Ala Leu Thr Leu Phe Asp Val Ser His225 230 235 240cac tat cac act gca ccc gtc atc aag aat gca tcc gtg cag ctg gaa 768His Tyr His Thr Ala Pro Val Ile Lys Asn Ala Ser Val Gln Leu Glu

245 250 255cca ggg gaa cac atc gcc att gtg ggt gcg acc ggc gct ggt aaa agc 816Pro Gly Glu His Ile Ala Ile Val Gly Ala Thr Gly Ala Gly Lys Ser

260 265 270acg ctc gcc ctc att gcg gca ggc ctg ctc agc cca act tcc ggg cag 864Thr Leu Ala Leu Ile Ala Ala Gly Leu Leu Ser Pro Thr Ser Gly Gln

275 280 285gtg gct ctc ggc gga tcg agt ttt tctaac gtc gaa ccg gaa gca ttg 912Val Ala Leu Gly Gly Ser Ser Phe Ser Asn Val Glu Pro Glu Ala Leu

290 295 300cgc cag aag atc gcg atg gtc agc caa gaa atc cac tgc ttc cga gga 960Arg Gln Lys Ile Ala Met Val Ser Gln Glu Ile His Cys Phe Arg Gly305 310 315 320tct gtt tta gat aat ctt cgt atc gca cgc ccc gaa gcc acc gat gcg 1008Ser Val Leu Asp Asn Leu Arg Ile Ala Arg Pro Glu Ala Thr Asp Ala

325 330 335gac atc cac gcc gtt ctc gcc gat att ggt gat tcc tgg ttg gag cgc 1056Asp Ile His Ala Val Leu Ala Asp Ile Gly Asp Ser Trp Leu Glu Arg

340 345 350tta ccg caa ggc ata gac acc atc gtg ggt gat ggc gct ttc cgt tta 1104Leu Pro Gln Gly Ile Asp Thr Ile Val Gly Asp Gly Ala Phe Arg Leu

355 360 365acc tct gtg gaa aac cag atc atg gcg ctt gct cgc gta cat ttg gcc 1152Thr Ser Val Glu Asn Gln Ile Met Ala Leu Ala Arg Val His Leu Ala

370 375 380gac cta gca atc gtc atc ctt gat gaa gca acg gct gaa tca ggc tct 1200Asp Leu Ala Ile Val Ile Leu Asp Glu Ala Thr Ala Glu Ser Gly Ser385 390 395 400gat cat gca aaa cag ctt gaa gat gca gcc ctt aaa gtc act gaa aac 1248Asp His Ala Lys Gln Leu Glu Asp Ala Ala Leu Lys Val Thr Glu Asn

405 410 415aga tca gcc atc atc gtg gct cac cgc ctc aac caa gcg aaa acc gcc 1296Arg Ser Ala Ile Ile Val Ala His Arg Leu Asn Gln Ala Lys Thr Ala

420 425 430gat cgc atc atc gtc atg gac tcc gga gaa atc ata gaa tct gga acc 1344Asp Arg Ile Ile Val Met Asp Ser Gly Glu Ile Ile Glu Ser Gly Thr

435 440 445cat gaa gag ctt cga gcg atc ggc ggt cga tat gaa caa ctg tgg act 1392His Glu Glu Leu Arg Ala Ile Gly Gly Arg Tyr Glu Gln Leu Trp Thr

450455460 gcg tgg tct gcg cgc taattagcca cccaagacca cgc 1430Ala Trp Ser Ala Arg465<210>346<211>469<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>346Val Ser Leu Asp Ala Asn Thr Ile Glu Thr Ala Gly Arg Gly Asp Val 151015 Ile Ser Arg Ile Ala Asp Asp Ser Arg Glu Val Ser Thr Ala Ala Ser

20 25 30Thr Val Val Pro Leu Met Val Gln Ala Gly Phe Thr Val Val Ile Ser

35 40 45Ala Phe Gly Met Ala Ala Val Asp Trp Arg Leu Gly Leu Val Gly Leu

50 55 60Val Ala Ile Pro Leu Tyr Trp Thr Thr Leu Arg Val Tyr Leu Pro Arg 65 70 75 80Ser Gly Pro Leu Tyr Thr Arg Glu Arg Glu Ala Phe Gly Val Arg Thr

85 90 95Gln Arg Leu Val Gly Ala Val Glu Gly Ala Glu Thr Leu Arg Ala Phe

100 105 110Arg Ala Glu Asp Thr Glu Leu Lys Arg Ile Asp Ala Ala Ser Gly Glu

115 120 125Ala Arg Asp Ile Ser Ile Ser Val Phe Arg Phe Leu Thr Trp Ala Phe

130 135 140Ser Arg Asn Asn Arg Ala Glu Cys Ile Thr Leu Val Leu Ile Leu Gly145 150 155 160Thr Gly Phe Tyr Leu Val Asn Ile Asp Leu Val Thr Val Gly Ala Val

165 170 175Ser Thr Ala Ala Leu Ile Phe His Arg Leu Phe Gly Pro Ile Gly Thr

180 185 190Leu Val Gly Met Phe Ser Asp Ile Gln Ser Ala Ser Ala Ser Leu Ile

195 200 205Arg Met Val Gly Val Ile Ash Ala Ala Ser Asn Gln Val Ser Gly Thr

210 215 220Ser Pro Ala Ser Ala Ser Thr Ala Leu Thr Leu Phe Asp Val Ser His225 230 235 240His Tyr His Thr Ala Pro Val Ile Lys Asn Ala Ser Val Gln Leu Glu

245 250 255Pro Gly Glu His Ile Ala Ile Val Gly Ala Thr Gly Ala Gly Lys Ser

260 265 270Thr Leu Ala Leu Ile Ala Ala Gly Leu Leu Ser Pro Thr Ser Gly Gln

275 280 285Val Ala Leu Gly Gly Ser Ser Phe Ser Asn Val Glu Pro Glu Ala Leu

290 295 300Arg Gln Lys Ile Ala Met Val Ser Gln Glu Ile His Cys Phe Arg Gly305 310 315 320Ser Val Leu Asp Asn Leu Arg Ile Ala Arg Pro Glu Ala Thr Asp Ala

325 330 335Asp Ile His Ala Val Leu Ala Asp Ile Gly Asp Ser Trp Leu Glu Arg

340 345 350Leu Pro Gln Gly Ile Asp Thr Ile Val Gly Asp Gly Ala Phe Arg Leu

355 360 365Thr Ser Val Glu Asn Gln Ile Met Ala Leu Ala Arg Val His Leu Ala

370 375 380Asp Leu Ala Ile Val Ile Leu Asp Glu Ala Thr Ala Glu Ser Gly Ser385 390 395 400Asp His Ala Lys Gln Leu Glu Asp Ala Ala Leu Lys Val Thr Glu Asn

405 410 415Arg Ser Ala Ile Ile Val Ala His Arg Leu Asn Gln Ala Lys Thr Ala

420 425 430Asp Arg Ile Ile Val Met Asp Ser Gly Glu Ile Ile Glu Ser Gly Thr

435 440 445His Glu Glu Leu Arg Ala Ile Gly Gly Arg Tyr Glu Gln Leu Trp Thr

450455460 Ala Trp Ser Ala Arg465<210>347<211>1047<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1024)<223>RXN01212<400>347tttagaagcc acatgacata tgtcatgaaa attatgtgca aagtgcagta atactcctga 60catatggctc taccagcgcc aatgcgaagt aggaagaatt atg cct atg aca acg 115

Met Pro Met Thr Thr

1 5aca cca gca atc gac gta aca gac ctc gtg aga acc tac ggc gac tac 163Thr Pro Ala Ile Asp Val Thr Asp Leu Val Arg Thr Tyr Gly Asp Tyr

10 15 20acc gca gtc aag ggc ctg aat ttc cat gta cag cgc ggt gaa gta ttt 211Thr Ala Val Lys Gly Leu Asn Phe His Val Gln Arg Gly Glu Val Phe

25 30 35ggt ctg ctc ggc acc aac ggg gcc ggc aaa acc tcc acc ttg gaa gtc 259Gly Leu Leu Gly Thr Asn Gly Ala Gly Lys Thr Ser Thr Leu Glu Val

40 45 50atc gaa gga ctt tcc gca ccc agc tcc ggc acc gtg cgc atc tcc ggg 307Ile Glu Gly Leu Ser Ala Pro Ser Ser Gly Thr Val Arg Ile Ser Gly

55 60 65ctt gac ccc gtt gcc gac cgc gcg atc ctg cgc ccc gag ctc ggc atc 355Leu Asp Pro Val Ala Asp Arg Ala Ile Leu Arg Pro Glu Leu Gly Ile 7075 80 85atg ctg caa tca ggc ggc ctg cca tca cag ctc acc gtc gcc gaa acc 403Met Leu Gln Ser Gly Gly Leu Pro Ser Gln Leu Thr Val Ala Glu Thr

90 95 100atg gac atg tgg cac ggc acc tgc acg tat ccg cgc gcc att aaa gat 451Met Asp Met Trp His Gly Thr Cys Thr Tyr Pro Arg Ala Ile Lys Asp

105 110 115gtg ctt gcc gac gtc gac ctc cta cac cgc gaa aac gtc aag gtc ggc 499Val Leu Ala Asp Val Asp Leu Leu His Arg Glu Asn Val Lys Val Gly

120 125 130gcg ctt tcc gga ggc gaa caa cga cgc ctt gat ttg gcc tgc gca ctg 547Ala Leu Ser Gly Gly Glu Gln Arg Arg Leu Asp Leu Ala Cys Ala Leu

135 140 145ctt ggc gac ccc tca att ttg ttc ctc gac gaa ccc acc acc ggc ctc 595Leu Gly Asp Pro Ser Ile Leu Phe Leu Asp Glu Pro Thr Thr Gly Leu150 155 160 165gac cca gaa tct agg cgc cac acc tgg caa ctc ctg ctg gac ctg aaa 643Asp Pro Glu Ser Arg Arg His Thr Trp Gln Leu Leu Leu Asp Leu Lys

170 175 180cag cgc ggc gtc acc atg atg ctg acc acc cac tac ctg gag gaa gcc 691Gln Arg Gly Val Thr Met Met Leu Thr Thr His Tyr Leu Glu Glu Ala

185 190 195gaa ttc ctc tgc gac cgg att gcc atc atg aac gcc ggt gag atc gca 739Glu Phe Leu Cys Asp Arg Ile Ala Ile Met Asn Ala Gly Glu Ile Ala

200 205 210gtg gaa ggc acc ttg gat gaa ctg gtg gcc cgc gag aag tcg atc atc 787Val Glu Gly Thr Leu Asp Glu Leu Val Ala Arg Glu Lys Ser Ile Ile

215 220 225agt ttc gtg ctg cgt ggc ggg cag gtg gag ttg ccg gtc ttg agt ggg 835SerPhe Val Leu Arg Gly Gly Gln Val Glu Leu Pro Val Leu Ser Gly230 235 240 245gct gaa atc atc cgc gac aac aac cac gtc cgc atc gcc acc acc acc 883Ala Glu Ile Ile Arg Asp Asn Asn His Val Arg Ile Ala Thr Thr Thr

250 255 260ctg cag cag cac acc tta gaa ata ctt acc tgg gct gca gag acc ggg 931Leu Gln Gln His Thr Leu Glu Ile Leu Thr Trp Ala Ala Glu Thr Gly

265 270 275atc gcg ctg gaa ggc ttc gct gca aaa ccc gcc acc ttg gaa tcc gta 979Ile Ala Leu Glu Gly Phe Ala Ala Lys Pro Ala Thr Leu Glu Ser Val

280 285 290ttc atg gac atc gcc tca ctc gag aac acc tcg ctg caa acc gcc 1024Phe Met Asp Ile Ala Ser Leu Glu Asn Thr Ser Leu Gln Thr Ala

295300305 tagaatcttt aaggagacca caa 1047<210>348<211>308<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>348Met Pro Met Thr Thr Thr Pro Ala Ile Asp Val Thr Asp Leu Val Arg 151015 Thr Tyr Gly Asp Tyr Thr Ala Val Lys Gly Leu Asn Phe His Val Gln

20 25 30Arg Gly Glu Val Phe Gly Leu Leu Gly Thr Asn Gly Ala Gly Lys Thr

35 40 45Ser Thr Leu Glu Val Ile Glu Gly Leu Ser Ala Pro Ser Ser Gly Thr

50 55 60Val Arg Ile Ser Gly Leu Asp Pro Val Ala Asp Arg Ala Ile Leu Arg 65 70 75 80Pro Glu Leu Gly Ile Met Leu Gln Ser Gly Gly Leu Pro Ser Gln Leu

85 90 95Thr Val Ala Glu Thr Met Asp Met Trp His Gly Thr Cys Thr Tyr Pro

100105 110Arg Ala Ile Lys Asp Val Leu Ala Asp Val Asp Leu Leu His Arg Glu

115 120 125Asn Val Lys Val Gly Ala Leu Ser Gly Gly Glu Gln Arg Arg Leu Asp

130 135 140Leu Ala Cys Ala Leu Leu Gly Asp Pro Ser Ile Leu Phe Leu Asp Glu145 150 155 160Pro Thr Thr Gly Leu Asp Pro Glu Ser Arg Arg His Thr Trp Gln Leu

165 170 175Leu Leu Asp Leu Lys Gln Arg Gly Val Thr Met Met Leu Thr Thr His

180 185 190Tyr Leu Glu Glu Ala Glu Phe Leu Cys Asp Arg Ile Ala Ile Met Asn

195 200 205Ala Gly Glu Ile Ala Val Glu Gly Thr Leu Asp Glu Leu Val Ala Arg

210 215 220Glu Lys Ser Ile Ile Ser Phe Val Leu Arg Gly Gly Gln Val Glu Leu225 230 235 240Pro Val Leu Ser Gly Ala Glu Ile Ile Arg Asp Asn Asn His Val Arg

245 250 255Ile Ala Thr Thr Thr Leu Gln Gln His Thr Leu Glu Ile Leu Thr Trp

260 265 270Ala Ala Glu Thr Gly Ile Ala Leu Glu Gly Phe Ala Ala Lys Pro Ala

275 280 285Thr Leu Glu Ser Val Phe Met Asp Ile Ala Ser Leu Glu Asn Thr Ser

290295300 Leu Gln Thr Ala305<210>349<211>813<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (813)<223>FRXA01212<400>349ggc ctg aat ttc cat gta cag cgc ggt gaa gta ttt ggt ctg ctc ggc 48Gly Leu Asn Phe His Val Gln Arg Gly Glu Val Phe Gly Leu Leu Gly 151015 acc aac ggg gcc ggc aaa acc tcc acc ttg gaa gtc atc gaa gga ctt 96Thr Asn Gly Ala Gly Lys Thr Ser Thr Leu Glu Val Ile Glu Gly Leu

20 25 30tcc gca ccc agc tcc ggc acc gtg cgc atc tce ggg ctt gac ccc gtt 144Ser Ala Pro Ser Ser Gly Thr Val Arg Ile Ser Gly Leu Asp Pro Val

35 40 45gcc gac cgc gcg atc ctg cgc ccc gag ctc ggc atc atg ctg caa tca 192Ala Asp Arg Ala Ile Leu Arg Pro Glu Leu Gly Ile Met Leu Gln Ser

50 55 60ggc ggc ctg cea tca cag ctc acc gtc gcc gaa acc atg gac atg tgg 240Gly Gly Leu Pro Ser Gln Leu Thr Val Ala Glu Thr Met Asp Met Trp 65 70 75 80cac ggc acc tgc acg tat ccg cgc gcc att aaa gat gtg ctt gcc gac 288His Gly Thr Cys Thr Tyr Pro Arg Ala Ile Lys Asp Val Leu Ala Asp

85 90 95gtc gac ctc cta cac cgc gaa aac gtc aag gtc ggc gcg ctt tcc gga 336Val Asp Leu Leu His Arg Glu Asn Val Lys Val Gly Ala Leu Ser Gly

100 105 110ggc gaa caa cga cgc ctt gat ttg gcc tgc gca ctg ctt ggc gac ccc 384Gly Glu Gln Arg Arg Leu Asp Leu Ala Cys Ala Leu Leu Gly Asp Pro

115 120 125tca att ttg ttc ctc gac gaa ccc acc acc ggc ctc gac cca gaa tct 432Ser Ile Leu Phe Leu Asp Glu Pro Thr Thr Gly Leu Asp Pro Glu Ser

130 135 140agg cgc cac acc tgg caa ctc ctg ctg gac ctg aaa cag cgc ggc gtc 480Arg Arg His Thr Trp Gln Leu Leu Leu Asp Leu Lys Gln Arg Gly Val145 150 155 160acc atg atg ctg acc acc cac tac ctg gag gaa gcc gaa ttc ctc tgc 528Thr Met Met Leu Thr Thr His Tyr Leu Glu Glu Ala Glu Phe Leu Cys

165 170 175gac cgg att gcc atc atg aac gcc ggt gag atc gca gtg gaa ggc acc 576Asp Arg Ile Ala Ile Met Asn Ala Gly Glu Ile Ala Val Glu Gly Thr

180 185 190ttg gat gaa ctg gtg gcc cgc gag aag tcg atc atc agt ttc gtg ctg 624Leu Asp Glu Leu Val Ala Arg Glu Lys Ser Ile Ile Ser Phe Val Leu

195 200 205cgt ggc ggg cag gtg gag ttg ccg gtc ttg agt ggg gct gaa atc atc 672Arg Gly Gly Gln Val Glu Leu Pro Val Leu Ser Gly Ala Glu Ile Ile

210 215 220cgc gac aac aac cac gtc cgc atc gcc acc acc acc ctg cag cag cac 720Arg Asp Asn Asn His Val Arg Ile Ala Thr Thr Thr Leu Gln Gln His225 230 235 240acc tta gaa ata ctt acc tgg gct gca gag acc ggg atc gcg ctg gaa 768Thr Leu Glu Ile Leu Thr Trp Ala Ala Glu Thr Gly Ile Ala Leu Glu

245 250 255ggc ttc gct gca aaa ccc gcc acc ttg gaa tcc gta ttc atg gac 813Gly Phe Ala Ala Lys Pro Ala Thr Leu Glu Ser Val Phe Met Asp

260265270<210>350<211>271<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>350Gly Leu Asn Phe His Val Gln Arg Gly Glu Val Phe Gly Leu Leu Gly 151015 Thr Asn Gly Ala Gly Lys Thr Ser Thr Leu Glu Val Ile Glu Gly Leu

20 25 30Ser Ala Pro Ser Ser Gly Thr Val Arg Ile Ser Gly Leu Asp Pro Val

35 40 45Ala Asp Arg Ala Ile Leu Arg Pro Glu Leu Gly Ile Met Leu Gln Ser

50 55 60Gly Gly Leu Pro Ser Gln Leu Thr Val Ala Glu Thr Met Asp Met Trp 65 70 75 80His Gly Thr Cys Thr Tyr Pro Arg Ala Ile Lys Asp Val Leu Ala Asp

85 90 95Val Asp Leu Leu His Arg Glu Asn Val Lys Val Gly Ala Leu Ser Gly

100 105 110Gly Glu Gln Arg Arg Leu Asp Leu Ala Cys Ala Leu Leu Gly Asp Pro

115 120 125Ser Ile Leu Phe Leu Asp Glu Pro Thr Thr Gly Leu Asp Pro Glu Ser

130 135 140Arg Arg His Thr Trp Gln Leu Leu Leu Asp Leu Lys Gln Arg Gly Val145 150 155 160Thr Met Met Leu Thr Thr His Tyr Leu Glu Glu Ala Glu Phe Leu Cys

165 170 175Asp Arg Ile Ala Ile Met Asn Ala Gly Glu Ile Ala Val Glu Gly Thr

180 185 190Leu Asp Glu Leu Val Ala Arg Glu Lys Ser Ile Ile Ser Phe Val Leu

195 200 205Arg Gly Gly Gln Val Glu Leu Pro Val Leu Ser Gly Ala Glu Ile Ile

210 215 220Arg Asp Asn Asn His Val Arg Ile Ala Thr Thr Thr Leu Gln Gln His225 230 235 240Thr Leu Glu Ile Leu Thr Trp Ala Ala Glu Thr Gly Ile Ala Leu Glu

245 250 255Gly Phe Ala Ala Lys Pro Ala Thr Leu Glu Ser Val Phe Met Asp

260265270<210>351<211>999<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (976)<223>RXA02749<400>351caacctagac ttcggtaaga agtaactttg ctttagttgg tcggcgcatc actttcccta 60agcgatgcgc cgattacttg tttttgctac aaatttaact atg tca ccc atc cta 115

Met Ser Pro Ile Leu

1 5aaa gtg cgg gac ctc gtc aaa cgc tat ggc gac acc gtt gcg gtt gac 163Lys Val Arg Asp Leu Val Lys Arg Tyr Gly Asp Thr Val Ala Val Asp

10 15 20ggt tta aat ttt gat gtt tca caa ggg gaa att ttt gcc ttt cta ggg 211Gly Leu Asn Phe Asp Val Ser Gln Gly Glu Ile Phe Ala Phe Leu Gly

25 30 35gag aac ggc gca gga aaa aca acc acg att tca tgc ctg att ggc att 259Glu Asn Gly Ala Gly Lys Thr Thr Thr Ile Ser Cys Leu Ile Gly Ile

40 45 50gat caa gcc acc tct ggg gag atc gaa ctg cag ggt ggc caa gta gat 307Asp Gln Ala Thr Ser Gly Glu Ile Glu Leu Gln Gly Gly Gln Val Asp

55 60 65tct gaa aaa ctt gga gtg gtg ttt caa caa tcc gtc tta gac cct ttg 355Ser Glu Lys Leu Gly Val Val Phe Gln Gln Ser Val Leu Asp Pro Leu 70 75 80 85ctg agt gcc aaa gaa aac ttg gaa aca cgc gga cag ctg tac cca ggg 403Leu Ser Ala Lys Glu Asn Leu Glu Thr Arg Gly Gln Leu Tyr Pro Gly

90 95 100gtg ggg aag cag cgg gtt gca cag ctc att gag caa atc ggg atg gaa 451Val Gly Lys Gln Arg Val Ala Gln Leu Ile Glu Gln Ile Gly Met Glu

105 110 115ggg ttt gcg gac cgc cga tac gga gtg ttg tcg ggc ggt gaa aaa cgt 499Gly Phe Ala Asp Arg Arg Tyr Gly Val Leu Ser Gly Gly Glu Lys Arg

120 125 130cgc accgac atc gca cga gct tta ctg cac agc cca gac att ctt ttt 547Arg Thr Asp Ile Ala Arg Ala Leu Leu His Ser Pro Asp Ile Leu Phe

135 140 145ctt gat gaa ccc aca gca ggc ctc gac ccc aga tca cga cgc caa gtt 595Leu Asp Glu Pro Thr Ala Gly Leu Asp Pro Arg Ser Arg Arg Gln Val150 155 160 165tgg gac acc atc aat tcc ctg cgt aac gat gtg ggc ctc act gtc ttt 643Trp Asp Thr Ile Asn Ser Leu Arg Asn Asp Va1 Gly Leu Thr Val Phe

170 175 180ttg acc act cac tac atg gaa gaa aca gaa ctg gct gat tca gtt cta 691Leu Thr Thr His Tyr Met Glu Glu Thr Glu Leu Ala Asp Ser Val Leu

185 190 195atc att gac cgt ggc aaa gag gtc gca tca gga acc ccg atg gaa ctg 739Ile Ile Asp Arg Gly Lys Glu Val Ala Ser Gly Thr Pro Met Glu Leu

200 205 210cgc gcc cgt tac acc aca aca gaa ttg act ctt aga aca aac gac cct 787Arg Ala Arg Tyr Thr Thr Thr Glu Leu Thr Leu Arg Thr Asn Asp Pro

215 220 225act cat tcg ggt aaa gag ttg gcc cac ttg agc cca gaa atc gac ggt 835Thr His Ser Gly Lys Glu Leu Ala His Leu Ser Pro Glu Ile Asp Gly230 235 240 245gac cga ctg cgg atc aag ttg gaa aat ggg ctc gaa gct gcg cgc ctg 883Asp Arg Leu Arg Ile Lys Leu Glu Asn Gly Leu Glu Ala Ala Arg Leu

250 255 260gca aca gaa cta gat ggg gtt ctc gac gta gag atc cgc cac ggt tcc 931Ala Thr Glu Leu Asp Gly Val Leu Asp Val Glu Ile Arg His Gly Ser

265 270 275atg gac gat gta ttt cta gca gtt aca gct gaa cgg aaa cga tca 976Met Asp Asp Val Phe Leu Ala Val Thr Ala Glu Arg Lys Arg Ser

280285290 tgattacagt tctgacacgc aga 999<210>352<211>292<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>352Met Ser Pro Ile Leu Lys Val Arg Asp Leu Val Lys Arg Tyr Gly Asp 151015 Thr Val Ala Val Asp Gly Leu Asn Phe Asp Val Ser Gln Gly Glu Ile

20 25 30Phe Ala Phe Leu Gly Glu Asn Gly Ala Gly Lys Thr Thr Thr Ile Ser

35 40 45Cys Leu Ile Gly Ile Asp Gln Ala Thr Ser Gly Glu Ile Glu Leu Gln

50 55 60Gly Gly Gln Val Asp Ser Glu Lys Leu Gly Val Val Phe Gln Gln Ser 65 70 75 80Val Leu Asp Pro Leu Leu Ser Ala Lys Glu Asn Leu Glu Thr Arg Gly

85 90 95Gln Leu Tyr Pro Gly Val Gly Lys Gln Arg Val Ala Gln Leu Ile Glu

100 105 110Gln Ile Gly Met Glu Gly Phe Ala Asp Arg Arg Tyr Gly Val Leu Ser

115 120 125Gly Gly Glu Lys Arg Arg Thr Asp Ile Ala Arg Ala Leu Leu His Ser

130 135 140Pro Asp Ile Leu Phe Leu Asp Glu Pro Thr Ala Gly Leu Asp Pro Arg145 150 155 160Ser Arg Arg Gln Val Trp Asp Thr Ile Asn Ser Leu Arg Asn Asp Val

165 170 175Gly Leu Thr Val Phe Leu Thr Thr His Tyr Met Glu Glu Thr Glu Leu

180 185 190Ala Asp Ser Val Leu Ile Ile Asp Arg Gly Lys Glu Val Ala Ser Gly

195 200 205Thr Pro Met Glu Leu Arg Ala Arg Tyr Thr Thr Thr Glu Leu Thr Leu

210 215 220Arg Thr Asn Asp Pro Thr His Ser Gly Lys Glu Leu Ala His Leu Ser225 230 235 240Pro Glu Ile Asp Gly Asp Arg Leu Arg Ile Lys Leu Glu Asn Gly Leu

245 250 255Glu Ala Ala Arg Leu Ala Thr Glu Leu Asp Gly Val Leu Asp Val Glu

260 265 270Ile Arg His Gly Ser Met Asp Asp Val Phe Leu Ala Val Thr Ala Glu

275 280 285Arg Lys Arg Ser

290<210>353<211>1920<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1897)<223>RXA02224<400>353gcttcgtcga ggccggaaaa ccgtcgtcat tacgtcgaac ccgacgtggc acggcgtcgc 60aaagcagatg caatctgatt tttcggaagg ggtgaagtag atg gcg cag cat gag 115

Met Ala Gln His Glu

1 5cgc gtt gcg gat gcg ctg cag ccg gcg tcg ttg gcg gag tcg tgg cgt 163Arg Val Ala Asp Ala Leu Gln Pro Ala Ser Leu Ala Glu Ser Trp Arg

10 15 20gag ctg aaa acg atg cct tcg ggg ccc aag gcc tgg tgg tat gtg agt 211Glu Leu Lys Thr Met Pro Ser Gly Pro Lys Ala Trp Trp Tyr Val Ser

25 30 35ttc gtg gtt att agc gtg gtc acg gtc gtg gcg atg gtc ggc acg tcc 259Phe Val Val Ile Ser Val Val Thr Val Val Ala Met Val Gly Thr Ser

40 45 50aac ttg ttg ggc tat tcc gtt gat ctg atc aat ggg cag tcg ttg ccg 307Asn Leu Leu Gly Tyr Ser Val Asp Leu Ile Asn Gly Gln Ser Leu Pro

55 60 65ctg atc ggt tca gga tcg acc gca atg atc tgg ttg ctt ggt ttg gtg 355Leu Ile Gly Ser Gly Ser Thr Ala Met Ile Trp Leu Leu Gly Leu Val 70 75 80 85ggc gct gga att tta gca gaa act gcc ggt cgc gcg ctg ctg caa ttg 403Gly Ala Gly Ile Leu Ala Glu Thr Ala Gly Arg Ala Leu Leu Gln Leu

90 95 100gtg atc aac acc ttg gca cgt cgc ctg tcg gtg gat ctg cgg aaa gct 451Val Ile Asn Thr Leu Ala Arg Arg Leu Ser Val Asp Leu Arg Lys Ala

105 110 115gcg ctg tct tcg gcg ttg cgt gca ccg gtt cct gat gtc atg gaa ttg 499Ala Leu Ser Ser Ala Leu Arg Ala Pro Val Pro Asp Val Met Glu Leu

120 125 130ggc acg gga aac gtg att agc cgc ctg acg caa gac atc gat aac act 547Gly Thr Gly Asn Val Ile Ser Arg Leu Thr Gln Asp Ile Asp Asn Thr

135 140 145gtg cgc atc gtc ggc atg gta ggt gtg cgt ttg gtg atc acc att ttg 595Val Arg Ile Val Gly Met Val Gly Val Arg Leu Val Ile Thr Ile Leu150 155 160 165att ctg ccc agc tcc ttg ttc gcg ttg atg acc att cac tgg acc ttt 643Ile Leu Pro Ser Ser Leu Phe Ala Leu Met Thr Ile His Trp Thr Phe

170 175 180gtg atc ctg ttc atc gca gtg att gtg gtg ctg att ccc agc ggt cgg 691Val Ile Leu Phe Ile Ala Val Ile Val Val Leu Ile Pro Ser Gly Arg

185 190 195aaa gcc gtg cga gct att cct tcg gca aca aat att gtg tcc agt acg 739Lys Ala Val Arg Ala Ile Pro Ser Ala Thr Asn Ile Val Ser Ser Thr

200 205210gag gcg cgt cga aac aat ctg ctc ctc gat acg atc cgt ggc att gaa 787Glu Ala Arg Arg Asn Asn Leu Leu Leu Asp Thr Ile Arg Gly Ile Glu

215 220 225aca ctg cgt gtg ctc aag ctc ggt gcg tgg ggt gtg cag cgg atg cgc 835Thr Leu Arg Val Leu Lys Leu Gly Ala Trp Gly Val Gln Arg Met Arg230 235 240 245caa gcg tcg tgg act gcg gtg caa gca aca gct gat cgc gcg ccg att 883Gln Ala Ser Trp Thr Ala Val Gln Ala Thr Ala Asp Arg Ala Pro Ile

250 255 260ttc act cgt ctg ctc gcc ctt ggt tcg att gct tat ggc ctg ctg cta 931Phe Thr Arg Leu Leu Ala Leu Gly Ser Ile Ala Tyr Gly Leu Leu Leu

265 270 275att ggc gtg ttt ggg ctc agt gcg ttt tgg gtt gcc cag gat gcg atg 979Ile Gly Val Phe Gly Leu Ser Ala Phe Trp Val Ala Gln Asp Ala Met

280 285 290agc att gga gcg gca acg gca gca gtt ttc gtg gtt gtg cgc atg gaa 1027Ser Ile Gly Ala Ala Thr Ala Ala Val Phe Val Val Val Arg Met Glu

295 300 305att cac gtg ttc aac gtg ctg ttc ttc gca tcg gaa att cag agt gcg 1075Ile His Val Phe Asn Val Leu Phe Phe Ala Ser Glu Ile Gln Ser Ala310 315 320 325tct act tct ctt ggt cgc gcg gtg tcc ctt gcc cag atg gct cgt cgc 1123Ser Thr Ser Leu Gly Arg Ala Val Ser Leu Ala Gln Met Ala Arg Arg

330 335 340acc gaa cag ctg tct gag tct gcc gat tgc aca gaa cca ccc tcc gtg 1171Thr Glu Gln Leu Ser Glu Ser Ala Asp Cys Thr Glu Pro Pro Ser Val

345 350 355act gtg cag gac gtg acg ttt aaa tat ccc ggc ggc gtg gcc att ttg 1219Thr Val Gln Asp Val Thr Phe Lys Tyr Pro Gly Gly Val Ala Ile Leu

360 365 370gag gat ttc aat ctg gtc ttg gaa gca gga aca acc aca gcg ctg gtc 1267Glu Asp Phe Asn Leu Val Leu Glu Ala Gly Thr Thr Thr Ala Leu Val

375 380 385ggt act tct ggt gcg gga aaa tcc acg ctc gcg ggc gtc att gcg ggg 1315Gly Thr Ser Gly Ala Gly Lys Ser Thr Leu Ala Gly Val Ile Ala Gly390 395 400 405ctg cag cgc cct gat tcc ggc gcc gtt ttg gtc ggg ggc atc aac acc 1363Leu Gln Arg Pro Asp Ser Gly Ala Val Leu Val Gly Gly Ile Asn Thr

410 415 420gcc acc gtc acc gac acg tgg act acc cgc cag gtt gcg ctg atc agc 1411Ala Thr Val Thr Asp Thr Trp Thr Thr Arg Gln Val Ala Leu Ile Ser

425 430 435cag gaa gtc cac ctt ttc gca ggc act ctg gca gag gat ctt cgc atg 1459Gln Glu Val His Leu Phe Ala Gly Thr Leu Ala Glu Asp Leu Arg Met

440 445 450gcc aat gcg cac gcc acc gac gcg cag ctc cac gca gcg ctc gag tcg 1507Ala Asn Ala His Ala Thr Asp Ala Gln Leu His Ala Ala Leu Glu Ser

455 460 465gtc ggg ctc ggg caa atg aca act gct ttt cga cgt ttc ttt cca tcc 1555Val Gly Leu Gly Gln Met Thr Thr Ala Phe Arg Arg Phe Phe Pro Ser470 475 480 485gga tta gac acc aaa att ggc gcc ggc gca gaa gaa ctc acc cct gaa 1603Gly Leu Asp Thr Lys Ile Gly Ala Gly Ala Glu Glu Leu Thr Pro Glu

490 495 500atc caa cag caa atc tct ctt gcc cgc atc gtg ctc cgc aat cca cct 1651Ile Gln Gln Gln Ile Ser Leu Ala Arg Ile Val Leu Arg Asn Pro Pro

505 510515gtg ttg atc atg gat gaa gcc acc agt gaa gcc ggc agc gat gat gcc 1699Val Leu Ile Met Asp Glu Ala Thr Ser Glu Ala Gly Ser Asp Asp Ala

520 525 530cgc atg ttg gaa aaa gcc gcc aca gaa atc gca cga aac cgc acc acc 1747Arg Met Leu Glu Lys Ala Ala Thr Glu Ile Ala Arg Asn Arg Thr Thr

535 540 545ttg gtt gtt gcg cac cgc ctt gac caa gca gtt gtc gca gat cgc atc 1795Leu Val Val Ala His Arg Leu Asp Gln Ala Val Val Ala Asp Arg Ile550 555 560 565atc gtg atg gaa caa ggc aca atc acc gaa gac ggc act cac cag gaa 1843Ile Val Met Glu Gln Gly Thr Ile Thr Glu Asp Gly Thr His Gln Glu

570 575 580tta ctt gct ttt gag ggc cgc tac gcg cag ctg tat caa cga tgg agt 1891Leu Leu Ala Phe Glu Gly Arg Tyr Ala Gln Leu Tyr Gln Arg Trp Ser

585590595 gct caa tagttcaaat ccaccacaaa ctc 1920Ala 1920 Gln<210>354<211>599<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>354Met Ala Gln His Glu Arg Val Ala Asp Ala Leu Gln Pro Ala Ser Leu 151015 Ala Glu Ser Trp Arg Glu Leu Lys Thr Met Pro Ser Gly Pro Lys Ala

20 25 30Trp Trp Tyr Val Ser Phe Val Val Ile Ser Val Val Thr Val Val Ala

35 40 45Met Val Gly Thr Ser Asn Leu Leu Gly Tyr Ser Val Asp Leu Ile Asn

50 55 60Gly Gln Ser Leu Pro Leu Ile Gly Ser Gly Ser Thr Ala Met Ile Trp 65 70 75 80Leu Leu Gly Leu Val Gly Ala Gly Ile Leu Ala Glu Thr Ala Gly Arg

85 90 95Ala Leu Leu Gln Leu Val Ile Asn Thr Leu Ala Arg Arg Leu Ser Val

100 105 110Asp Leu Arg Lys Ala Ala Leu Ser Ser Ala Leu Arg Ala Pro Val Pro

115 120 125Asp Val Met Glu Leu Gly Thr Gly Asn Val Ile Ser Arg Leu Thr Gln

130 135 140Asp Ile Asp Asn Thr Val Arg Ile Val Gly Met Val Gly Val Arg Leu145 150 155 160Val Ile Thr Ile Leu Ile Leu Pro Ser Ser Leu Phe Ala Leu Met Thr

165 170 175Ile His Trp Thr Phe Val Ile Leu Phe Ile Ala Val Ile Val Val Leu

180 185 190Ile Pro Ser Gly Arg Lys Ala Val Arg Ala Ile Pro Ser Ala Thr Asn

195 200 205Ile Val Ser Ser Thr Glu Ala Arg Arg Asn Asn Leu Leu Leu Asp Thr

210 215 220Ile Arg Gly Ile Glu Thr Leu Arg Val Leu Lys Leu Gly Ala Trp Gly225 230 235 240Val Gln Arg Met Arg Gln Ala Ser Trp Thr Ala Val Gln Ala Thr Ala

245 250 255Asp Arg Ala Pro Ile Phe Thr Arg Leu Leu Ala Leu Gly Ser Ile Ala

260 265 270Tyr Gly Leu Leu Leu Ile Gly Val Phe Gly Leu Ser Ala Phe Trp Val

275 280 285Ala Gln Asp Ala Met Ser Ile Gly Ala Ala Thr Ala Ala Val Phe Val

290 295 300Val Val Arg Met Glu Ile His Val Phe Asn Val Leu Phe Phe Ala Ser305 310 315 320Glu Ile Gln Ser Ala Ser Thr Ser Leu Gly Arg Ala Val Ser Leu Ala

325 330 335Gln Met Ala Arg Arg Thr Glu Gln Leu Ser Glu Ser Ala Asp Cys Thr

340 345 350Glu Pro Pro Ser Val Thr Val Gln Asp Val Thr Phe Lys Tyr Pro Gly

355 360 365Gly Val Ala Ile Leu Glu Asp Phe Asn Leu Val Leu Glu Ala Gly Thr

370 375 380Thr Thr Ala Leu Val Gly Thr Ser Gly Ala Gly Lys Ser Thr Leu Ala385 390 395 400Gly Val Ile Ala Gly Leu Gln Arg Pro Asp Ser Gly Ala Val Leu Val

405 410 415Gly Gly Ile Asn Thr Ala Thr Val Thr Asp Thr Trp Thr Thr Arg Gln

420 425 430Val Ala Leu Ile Ser Gln Glu Val His Leu Phe Ala Gly Thr Leu Ala

435 440 445Glu Asp Leu Arg Met Ala Asn Ala His Ala Thr Asp Ala Gln Leu His

450 455 460Ala Ala Leu Glu Ser Val Gly Leu Gly Gln Met Thr Thr Ala Phe Arg465 470 475 480Arg Phe Phe Pro Ser Gly Leu Asp Thr Lys Ile Gly Ala Gly Ala Glu

485 490 495Glu Leu Thr Pro Glu Ile Gln Gln Gln Ile Ser Leu Ala Arg Ile Val

500 505 510Leu Arg Asn Pro Pro Val Leu Ile Met Asp Glu Ala Thr Ser Glu Ala

515 520 525Gly Ser Asp Asp Ala Arg Met Leu Glu Lys Ala Ala Thr Glu Ile Ala

530 535 540Arg Asn Arg Thr Thr Leu Val Val Ala His ArgLeu Asp Gln Ala Val545 550 555 560Val Ala Asp Arg Ile Ile Val Met Glu Gln Gly Thr Ile Thr Glu Asp

565 570 575Gly Thr His Gln Glu Leu Leu Ala Phe Glu Gly Arg Tyr Ala Gln Leu

580 585 590Tyr Gln Arg Trp Ser Ala Gln

595<210>355<211>1653<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1630)<223>RXN01602<400>355tgcaggccac atgcctccca gtgccgtctc tgcacgttga ttttcccctg ccacgactgg 60tcgcagggcg actttctagc acttttaaag gaatttttta atg gct aaa acc cat 115

Met Ala Lys Thr His

1 5att cgg tta cag gac ctt tcc ctg tca tac acc tca acc ccg tta att 163Ile Arg Leu Gln Asp Leu Ser Leu Ser Tyr Thr Ser Thr Pro Leu Ile

10 15 20acg aag ctc aat atc act gtt tct tct gga cag tgc gca gtg att gtt 211Thr Lys Leu Asn Ile Thr Val Ser Ser Gly Gln Cys Ala Val Ile Val

25 30 35ggt gag aat ggt cga ggt aaa acc aca ctt ctg cga gca ctg gct cga 259Gly Glu Asn Gly Arg Gly Lys Thr Thr Leu Leu Arg Ala Leu Ala Arg

40 45 50gaa ttc ccg cca tct gca ggt gag att ctc act cat ggc acg gta gca 307Glu Phe Pro Pro Ser Ala Gly Glu Ile Leu Thr His Gly Thr Val Ala

55 60 65att gct cat caa cac atg cct gca ggt gat ctg tcc gtc gga gag atc 355Ile Ala His Gln His Met Pro Ala Gly Asp Leu Ser Val Gly Glu Ile 70 75 8085tgt gat gag gca att cgt gat tca aag aat gct ctc gaa gag ctt gag 403Cys Asp Glu Ala Ile Arg Asp Ser Lys Asn Ala Leu Glu Glu Leu Glu

90 95 100aga gct gga gct cta ctt gag aca aac act gcg cac gca ctt gat gga 451Arg Ala Gly Ala Leu Leu Glu Thr Asn Thr Ala His Ala Leu Asp Gly

105 110 115tat caa caa gcc ctt gat gcc gct gaa gtg ctt gac gca tgg aac gct 499Tyr Gln Gln Ala Leu Asp Ala Ala Glu Val Leu Asp Ala Trp Asn Ala

120 125 130gaa cat cga tta gaa aaa gct ctg cgc agc ttt ggc gcg atc acc gat 547Glu His Arg Leu Glu Lys Ala Leu Arg Ser Phe Gly Ala Ile Thr Asp

135 140 145aga tcc cgt gca ctc agt gag cta tcg atc ggg caa agg tat cgg gta 595Arg Ser Arg Ala Leu Ser Glu Leu Ser Ile Gly Gln Arg Tyr Arg Val150 155 160 165cgg ctg gcc tgc ctc atc ggt ggc gat gct gat att ttg ctt ctc gat 643Arg Leu Ala Cys Leu Ile Gly Gly Asp Ala Asp Ile Leu Leu Leu Asp

170 175 180gaa ccc acc aat cat ctt gac cgg ggc gcg ctt aac tat ctc acc gaa 691Glu Pro Thr Asn His Leu Asp Arg Gly Ala Leu Asn Tyr Leu Thr Glu

185 190 195gcc ata acc tcc cac aaa ggt gtg gta ctt gtt gtt tct cat gat caa 739Ala Ile Thr Ser His Lys Gly Val Val Leu Val Val Ser His Asp Gln

200 205 210gca ctg atc aaa gat gtc gcg gat ttc atc atc gat att gat tca acc 787Ala Leu Ile Lys Asp Val Ala Asp Phe Ile Ile Asp Ile Asp Ser Thr

215 220 225cca gac ggc cta cca cgg atc tat cat gag ggt ttt gat tct tat cga 835ProAsp Gly Leu Pro Arg Ile Tyr His Glu Gly Phe Asp Ser Tyr Arg230 235 240 245cgc caa agg agt gcg ctt ctt gaa act tgg agg cag gat tat gcc gct 883Arg Gln Arg Ser Ala Leu Leu Glu Thr Trp Arg Gln Asp Tyr Ala Ala

250 255 260gca caa act gtg caa cag caa ttg cag gag gat cta gag cac gca cgc 931Ala Gln Thr Val Gln Gln Gln Leu Gln Glu Asp Leu Glu His Ala Arg

265 270 275cag cgg gtg aat tct tcg tgg aaa cct cca aaa gga acg gga aaa cac 979Gln Arg Val Asn Ser Ser Trp Lys Pro Pro Lys Gly Thr Gly Lys His

280 285 290act cgc gca tct cgg gct ccc gga gtg gtg cag gcc tta aag cga gca 1027Thr Arg Ala Ser Arg Ala Pro Gly Val Val Gln Ala Leu Lys Arg Ala

295 300 305cag gat gcg ttg gat agc aaa gcg ttg gac gtt ccc ccg gct ccg gcc 1075Gln Asp Ala Leu Asp Ser Lys Ala Leu Asp Val Pro Pro Ala Pro Ala310 315 320 325cca ttg ctt ctg cct acc ttg aaa gtg cga cca gat aaa ccc atg gtg 1123Pro Leu Leu Leu Pro Thr Leu Lys Val Arg Pro Asp Lys Pro Met Val

330 335 340gac ttt tcg gac ctt ttt gta ccc cac cgc ttg cgt ctg cca ggc tca 1171Asp Phe Ser Asp Leu Phe Val Pro His Arg Leu Arg Leu Pro Gly Ser

345 350 355cat tca gtg gta tca ggt gac aaa ata gtg atc act ggt gac aac ggc 1219His Ser Val Val Ser Gly Asp Lys Ile Val Ile Thr Gly Asp Asn Gly

360 365 370gct ggc aaa tca acg ctc atc gaa gtc ttg tct ggg gtt ttg act ccg 1267Ala Gly Lys Ser Thr Leu Ile Glu Val Leu Ser Gly Val Leu Thr Pro

375 380385gca agt ggt tcg gtt gca aac cat gcc cga act ggg gtt ctc ggc caa 1315Ala Ser Gly Ser Val Ala Asn His Ala Arg Thr Gly Val Leu Gly Gln390 395 400 405gaa tca ctt gtc ggc gag gtg cca tca ata gca cga gat cac gca gtt 1363Glu Ser Leu Val Gly Glu Val Pro Ser Ile Ala Arg Asp His Ala Val

410 415 420aag tgg gga ctt tta agt gtt gag gag agc cga ttt gcc cta cag gaa 1411Lys Trp Gly Leu Leu Ser Val Glu Glu Ser Arg Phe Ala Leu Gln Glu

425 430 435ttc tca att ggt caa cgc aga aga cta gat ttg gcc atg tcg tta gct 1459Phe Ser Ile Gly Gln Arg Arg Arg Leu Asp Leu Ala Met Ser Leu Ala

440 445 450ggc aat cct gaa ctg ttg ctt ctc gat gaa cct tcg aac cat ctg tct 1507Gly Asn Pro Glu Leu Leu Leu Leu Asp Glu Pro Ser Asn His Leu Ser

455 460 465atg cac ttg gtt tcc gca ctt aca gag tgg ctg gac acg acc gcg gct 1555Met His Leu Val Ser Ala Leu Thr Glu Trp Leu Asp Thr Thr Ala Ala470 475 480 485gca gtg atc atg gta acg cat gat cga cag cta ctc cgc gat acg gct 1603Ala Val Ile Met Val Thr His Asp Arg Gln Leu Leu Arg Asp Thr Ala

490 495 500cat tgg agg cac atc gag ttg aaa tct taagaattcg caagggcttt 1650His Trp Arg His Ile Glu Leu Lys Ser

505510 cac1653<210>356<211>510<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>356Met Ala Lys Thr His Ile Arg Leu Gln Asp Leu Ser Leu Ser Tyr Thr 151015 Ser Thr Pro Leu Ile Thr Lys Leu Asn Ile Thr Val Ser Ser Gly Gln

20 25 30Cys Ala Val Ile Val Gly Glu Asn Gly Arg Gly Lys Thr Thr Leu Leu

35 40 45Arg Ala Leu Ala Arg Glu Phe Pro Pro Ser Ala Gly Glu Ile Leu Thr

50 55 60His Gly Thr Val Ala Ile Ala His Gln His Met Pro Ala Gly Asp Leu 65 70 75 80Ser Val Gly Glu Ile Cys Asp Glu Ala Ile Arg Asp Ser Lys Asn Ala

85 90 95Leu Glu Glu Leu Glu Arg Ala Gly Ala Leu Leu Glu Thr Asn Thr Ala

100 105 110His Ala Leu Asp Gly Tyr Gln Gln Ala Leu Asp Ala Ala Glu Val Leu

115 120 125Asp Ala Trp Asn Ala Glu His Arg Leu Glu Lys Ala Leu Arg Ser Phe

130 135 140Gly Ala Ile Thr Asp Arg Ser Arg Ala Leu Ser Glu Leu Ser Ile Gly145 150 155 160Gln Arg Tyr Arg Val Arg Leu Ala Cys Leu Ile Gly Gly Asp Ala Asp

165 170 175Ile Leu Leu Leu Asp Glu Pro Thr Asn His Leu Asp Arg Gly Ala Leu

180 185 190Asn Tyr Leu Thr Glu Ala Ile Thr Ser His Lys Gly Val Val Leu Val

195 200 205Val Ser His Asp Gln Ala Leu Ile Lys Asp Val Ala Asp Phe Ile Ile

210 215 220Asp Ile Asp Ser Thr Pro Asp Gly Leu Pro Arg Ile Tyr His Glu Gly225 230 235 240Phe Asp Ser Tyr Arg Arg Gln Arg Ser Ala Leu Leu Glu Thr Trp Arg

245 250 255Gln Asp Tyr Ala Ala Ala Gln Thr Val GlnGln Gln Leu Gln Glu Asp

260 265 270Leu Glu His Ala Arg Gln Arg Val Asn Ser Ser Trp Lys Pro Pro Lys

275 280 285Gly Thr Gly Lys His Thr Arg Ala Ser Arg Ala Pro Gly Val Val Gln

290 295 300Ala Leu Lys Arg Ala Gln Asp Ala Leu Asp Ser Lys Ala Leu Asp Val305 310 315 320Pro Pro Ala Pro Ala Pro Leu Leu Leu Pro Thr Leu Lys Val Arg Pro

325 330 335Asp Lys Pro Met Val Asp Phe Ser Asp Leu Phe Val Pro His Arg Leu

340 345 350Arg Leu Pro Gly Ser His Ser Val Val Ser Gly Asp Lys Ile Val Ile

355 360 365Thr Gly Asp Asn Gly Ala Gly Lys Ser Thr Leu Ile Glu Val Leu Ser

370 375 380Gly Val Leu Thr Pro Ala Ser Gly Ser Val Ala Asn His Ala Arg Thr385 390 395 400Gly Val Leu Gly Gln Glu Ser Leu Val Gly Glu Val Pro Ser Ile Ala

405 410 415Arg Asp His Ala Val Lys Trp Gly Leu Leu Ser Val Glu Glu Ser Arg

420 425 430Phe Ala Leu Gln Glu Phe Ser Ile Gly Gln Arg Arg Arg Leu Asp Leu

435 440 445Ala Met Ser Leu Ala Gly Asn Pro Glu Leu Leu Leu Leu Asp Glu Pro

450 455 460Ser Asn His Leu Ser Met His Leu Val Ser Ala Leu Thr Glu Trp Leu465 470 475 480Asp Thr Thr Ala Ala Ala Val Ile Met Val Thr His Asp Arg Gln Leu

485 490 495Leu Arg Asp Thr Ala His Trp Arg His Ile Glu Leu Lys Ser

500505510<210>357<211>879<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (856)<223>RXN02515<400>357gtggctaagc acagttactt ggccaagctg ggcggcagaa aaaccggccc agctaatact 60tcagtttaaa attcgcttca accctgaaag attgtgacag atg agc act ctt gaa 115

Met Ser Thr Leu Glu

1 5atc cgt aac ctg cac gca cag gtc ctg ccg tcc gat gag tcc gct gag 163Ile Arg Asn Leu His Ala Gln Val Leu Pro Ser Asp Glu Ser Ala Glu

10 15 20cct aag gaa atc ctc aag ggc gtc aac ctc acc atc aac tct ggt gag 211Pro Lys Glu Ile Leu Lys Gly Val Asn Leu Thr Ile Asn Ser Gly Glu

25 30 35atc cac gcc atc atg ggc cct aac ggt tcc ggc aag tcc act ctt gct 259Ile His Ala Ile Met Gly Pro Asn Gly Ser Gly Lys Ser Thr Leu Ala

40 45 50tac acc ctt ggt gga cac cca cgc tac gag gta acc gca ggc gag gtc 307Tyr Thr Leu Gly Gly His Pro Arg Tyr Glu Val Thr Ala Gly Glu Val

55 60 65ctc ctc gac ggc gag aac atc ctg gag atg gaa gtt gat gag cgt gca 355Leu Leu Asp Gly Glu Asn Ile Leu Glu Met Glu Val Asp Glu Arg Ala 70 75 80 85cgc gct ggt ctc ttc ctg gcc atg cag tat cca act gaa atc cct ggc 403Arg Ala Gly Leu Phe Leu Ala Met Gln Tyr Pro Thr Glu Ile Pro Gly

90 95 100gtt tcc gtt gct aac ttc ctg cgt tcc gca gcg acc gca atc cgc ggc 451Val Ser Val Ala Asn Phe Leu Arg Ser Ala Ala Thr Ala Ile Arg Gly

105 110 115gag gct cct aag ctt cgc gag tgg gtt aag gaa gtc cgc acc gct cag 499Glu Ala Pro Lys Leu Arg Glu Trp Val Lys Glu Val Arg Thr Ala Gln

120 125 130gaa gct ctg gca att gac cct gag ttc tcc aac cgc tca gtc aac gaa 547Glu Ala Leu Ala Ile Asp Pro Glu Phe Ser Asn Arg Ser Val Asn Glu

135 140 145ggt ttc tcc ggt ggc gag aag aag cgc cac gag gtt ctg cag ctt gat 595Gly Phe Ser Gly Gly Glu Lys Lys Arg His Glu Val Leu Gln Leu Asp150 155 160 165ctg ctg aag cca aag ttc gcg atc atg gat gag acc gac tcc ggc ctt 643Leu Leu Lys Pro Lys Phe Ala Ile Met Asp Glu Thr Asp Ser Gly Leu

170 175 180gac gtg gat gca ctg cgc att gtt tcc gag ggc atc aac tcc tac aag 691Asp Val Asp Ala Leu Arg Ile Val Ser Glu Gly Ile Asn Ser Tyr Lys

185 190 195cag gag acc gaa ggt ggc atc ttg atg atc acc cac tac aag cgc atc 739Gln Glu Thr Glu Gly Gly Ile Leu Met Ile Thr His Tyr Lys Arg Ile

200 205 210ctc aac tac gtt aag cct gac ttc att cac gtt ttc gcg aat ggc cag 787Leu Asn Tyr Val Lys Pro Asp Phe Ile His Val Phe Ala Asn Gly Gln

215 220 225att gtg acc acc ggt ggc gct gag ctt gct gac aag ctc gag gct gac 835Ile Val Thr Thr Gly Gly Ala Glu Leu Ala Asp Lys Leu Glu Ala Asp230 235 240 245ggc tac gac cag ttc atc aag taacatgtcc gatttcctca atg 879Gly Tyr Asp Gln Phe Ile Lys

250<210>358<211>252<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>358Met Ser Thr Leu Glu Ile Arg Asn Leu His Ala Gln Val Leu Pro Ser 151015 Asp Glu Ser Ala Glu Pro Lys Glu Ile Leu Lys Gly Val Asn Leu Thr

20 25 30Ile Asn Ser Gly Glu Ile His Ala Ile Met Gly Pro Asn Gly Ser Gly

35 40 45Lys Ser Thr Leu Ala Tyr Thr Leu Gly Gly His Pro Arg Tyr Glu Val

50 55 60Thr Ala Gly Glu Val Leu Leu Asp Gly Glu Asn Ile Leu Glu Met Glu 65 70 75 80Val Asp Glu Arg Ala Arg Ala Gly Leu Phe Leu Ala Met Gln Tyr Pro

85 90 95Thr Glu Ile Pro Gly Val Ser Val Ala Asn Phe Leu Arg Ser Ala Ala

100 105 110Thr Ala Ile Arg Gly Glu Ala Pro Lys Leu Arg Glu Trp Val Lys Glu

115 120 125Val Arg Thr Ala Gln Glu Ala Leu Ala Ile Asp Pro Glu Phe Ser Asn

130 135 140Arg Ser Val Asn Glu Gly Phe Ser Gly Gly Glu Lys Lys Arg His Glu145 150 155 160Val Leu Gln Leu Asp Leu Leu Lys Pro Lys Phe Ala Ile Met Asp Glu

165 170 175Thr Asp Ser Gly Leu Asp Val Asp Ala Leu Arg Ile Val Ser Glu Gly

180 185 190Ile Asn Ser Tyr Lys Gln Glu Thr Glu Gly Gly Ile Leu Met Ile Thr

195 200 205His Tyr Lys Arg Ile Leu Asn Tyr Val Lys Pro Asp Phe Ile His Val

210215 220Phe Ala Asn Gly Gln Ile Val Thr Thr Gly Gly Ala Glu Leu Ala Asp225 230 235 240Lys Leu Glu Ala Asp Gly Tyr Asp Gln Phe Ile Lys

245250<210>359<211>1386<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1363)<223>RXN00525<400>359ccatcgtgtt tattactcac aaccctgagc ttgctgatga atctgatcgg gtggtcacca 60tggttgacgg gcgcatcatt gggtctgagg tgaaacactc atg agc ctt gca gaa 115

Met Ser Leu Ala Glu

1 5tca att ctt ttg gcg ctc acc agc ctg aga agc aac aag atg cgt gca 163Ser Ile Leu Leu Ala Leu Thr Ser Leu Arg Ser Asn Lys Met Arg Ala

10 15 20ttg ttg acg ctg tta gga gtc atc att ggt atc gca tca gtc atc gga 211Leu Leu Thr Leu Leu Gly Val Ile Ile Gly Ile Ala Ser Val Ile Gly

25 30 35att ttg acc att ggt aaa gcc ctg cag gat caa act ttg aat agt ttg 259Ile Leu Thr Ile Gly Lys Ala Leu Gln Asp Gln Thr Leu Asn Ser Leu

40 45 50gaa agc ttg ggc gcg aat gat ctg tcg gcg cag gtg gag gaa cgc ccc 307Glu Ser Leu Gly Ala Asn Asp Leu Ser Ala Gln Val Glu Glu Arg Pro

55 60 65gac gaa gat tcc ccc gaa ccc gat atg ttc gct ttt tct ggg gct gca 355Asp Glu Asp Ser Pro Glu Pro Asp Met Phe Ala Phe Ser Gly Ala Ala 70 75 80 85aac tct agt ggc aat ctg att ccg gaa gaa aca gtt gat acg ctg cgc 403Asn Ser Ser Gly Asn Leu Ile Pro Glu Glu Thr Val Asp Thr Leu Arg

9095 100gat cgt ttc gca ggc agc atc acg gga atc agc gtt ggc gga atg ggt 451Asp Arg Phe Ala Gly Ser Ile Thr Gly Ile Ser Val Gly Gly Met Gly

105 110 115acg caa ggc act ctc atc ggc gac acc gca gat ctt aaa tcc gat ctc 499Thr Gln Gly Thr Leu Ile Gly Asp Thr Ala Asp Leu Lys Ser Asp Leu

120 125 130ctc ggc gtc aac gag gat tat atg tgg atg aat ggc gtc gaa atg aac 547Leu Gly Val Asn Glu Asp Tyr Met Trp Met Asn Gly Val Glu Met Asn

135 140 145tac ggc cgc gcc atc acg caa gac gat gtt gcc gct cag cgc ccc gtt 595Tyr Gly Arg Ala Ile Thr Gln Asp Asp Val Ala Ala Gln Arg Pro Val150 155 160 165gcg gtc atc gcc cca gac acc ttt aat acg ctt ttc gac gca aac ccc 643Ala Val Ile Ala Pro Asp Thr Phe Asn Thr Leu Phe Asp Ala Asn Pro

170 175 180aac ctc gct ctg ggg tcc gaa gta gct ttt gaa ctc aac ggt caa gag 691Asn Leu Ala Leu Gly Ser Glu Val Ala Phe Glu Leu Asn Gly Gln Glu

185 190 195aca ttt ttg cgg gtt atc ggt gtg tat aaa gaa gcc gca gca ggt gga 739Thr Phe Leu Arg Val Ile Gly Val Tyr Lys Glu Ala Ala Ala Gly Gly

200 205 210ctt gtg gga agc aat cca acc gtc cac acc tac acc cca tat acg gtg 787Leu Val Gly Ser Asn Pro Thr Val His Thr Tyr Thr Pro Tyr Thr Val

215 220 225gcc aat gac atc acc cac acg gaa gat gga ttg aac acg tta agt atc 835Ala Asn Asp Ile Thr His Thr Glu Asp Gly Leu Asn Thr Leu Ser Ile230 235 240 245cgt gca gct cag ggc gta gac cag gat tca ctt aag ggt tca ctg caa 883Arg Ala AlaGln Gly Val Asp Gln Asp Ser Leu Lys Gly Ser Leu Gln

250 255 260acc tac ttc gac gcg ctg tac gcc aac aat gac tcg cac cac gtt gcc 931Thr Tyr Phe Asp Ala Leu Tyr Ala Asn Asn Asp Ser His His Val Ala

265 270 275atg ttg gac ttc cgt aaa cag atc gaa gag ttc aac acc att ctc ggc 979Met Leu Asp Phe Arg Lys Gln Ile Glu Glu Phe Asn Thr Ile Leu Gly

280 285 290gca atg agt ttg ggt atc tca gcc atc ggc gga att tcc ttg ctt gtc 1027Ala Met Ser Leu Gly Ile Ser Ala Ile Gly Gly Ile Ser Leu Leu Val

295 300 305ggt ggc atc gga gtg atg aac att atg ttg gtg tct gtc acc gag cga 1075Gly Gly Ile Gly Val Met Asn Ile Met Leu Val Ser Val Thr Glu Arg310 315 320 325acc cgc gaa atc ggt gtc cga aaa gcc ctc ggc gct cgt cga cgt gac 1123Thr Arg Glu Ile Gly Val Arg Lys Ala Leu Gly Ala Arg Arg Arg Asp

330 335 340att cgc ctg caa ttc gtc gtt gaa gcc atg atc att tgt ttc atc ggt 1171Ile Arg Leu Gln Phe Val Val Glu Ala Met Ile Ile Cys Phe Ile Gly

345 350 355ggc atc ctc ggc gtg ctt ttg ggc ggc att ttg gga ttg atc atg tcc 1219Gly Ile Leu Gly Val Leu Leu Gly Gly Ile Leu Gly Leu Ile Met Ser

360 365 370agc gct att ggc tac att tcc ttg cca cca ctg agt gga atc gtg atc 1267Ser Ala Ile Gly Tyr Ile Ser Leu Pro Pro Leu Ser Gly Ile Val Ile

375 380 385gcc ttg gta ttt tcc atg gct atc ggc ctg ttt ttc ggc tac tac ccc 1315Ala Leu Val Phe Ser Met Ala Ile Gly Leu Phe Phe Gly Tyr Tyr Pro390 395 400405gcc aac aag gca gca aag ctc gat cca att gac gcc ttg cgt tat gag 1363Ala Asn Lys Ala Ala Lys Leu Asp Pro Ile Asp Ala Leu Arg Tyr Glu

410415420 taaaagcctc gtttttaagg tag 1386<210>360<211>421<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>360Met Ser Leu Ala Glu Ser Ile Leu Leu Ala Leu Thr Ser Leu Arg Ser 151015 Asn Lys Met Arg Ala Leu Leu Thr Leu Leu Gly Val Ile Ile Gly Ile

20 25 30Ala Ser Val Ile Gly Ile Leu Thr Ile Gly Lys Ala Leu Gln Asp Gln

35 40 45Thr Leu Asn Ser Leu Glu Ser Leu Gly Ala Asn Asp Leu Ser Ala Gln

50 55 60Val Glu Glu Arg Pro Asp Glu Asp Ser Pro Glu Pro Asp Met Phe Ala 65 70 75 80Phe Ser Gly Ala Ala Asn Ser Ser Gly Asn Leu Ile Pro Glu Glu Thr

85 90 95Val Asp Thr Leu Arg Asp Arg Phe Ala Gly Ser Ile Thr Gly Ile Ser

100 105 110Val Gly Gly Met Gly Thr Gln Gly Thr Leu Ile Gly Asp Thr Ala Asp

115 120 125Leu Lys Ser Asp Leu Leu Gly Val Asn Glu Asp Tyr Met Trp Met Asn

130 135 140Gly Val Glu Met Asn Tyr Gly Arg Ala Ile Thr Gln Asp Asp Val Ala145 150 155 160Ala Gln Arg Pro Val Ala Val Ile Ala Pro Asp Thr Phe Asn Thr Leu

165 170 175Phe Asp Ala Asn Pro Asn Leu Ala Leu Gly Ser Glu Val Ala Phe Glu

180 185 190Leu Asn Gly Gln Glu Thr PheLeu Arg Val Ile Gly Val Tyr Lys Glu

195 200 205Ala Ala Ala Gly Gly Leu Val Gly Ser Asn Pro Thr Val His Thr Tyr

210 215 220Thr Pro Tyr Thr Val Ala Asn Asp Ile Thr His Thr Glu Asp Gly Leu225 230 235 240Asn Thr Leu Ser Ile Arg Ala Ala Gln Gly Val Asp Gln Asp Ser Leu

245 250 255Lys Gly Ser Leu Gln Thr Tyr Phe Asp Ala Leu Tyr Ala Asn Asn Asp

260 265 270Ser His His Val Ala Met Leu Asp Phe Arg Lys Gln Ile Glu Glu Phe

275 280 285Asn Thr Ile Leu Gly Ala Met Ser Leu Gly Ile Ser Ala Ile Gly Gly

290 295 300Ile Ser Leu Leu Val Gly Gly Ile Gly Val Met Asn Ile Met Leu Val305 310 315 320Ser Val Thr Glu Arg Thr Arg Glu Ile Gly Val Arg Lys Ala Leu Gly

325 330 335Ala Arg Arg Arg Asp Ile Arg Leu Gln Phe Val Val Glu Ala Met Ile

340 345 350Ile Cys Phe Ile Gly Gly Ile Leu Gly Val Leu Leu Gly Gly Ile Leu

355 360 365Gly Leu Ile Met Ser Ser Ala Ile Gly Tyr Ile Ser Leu Pro Pro Leu

370 375 380Ser Gly Ile Val Ile Ala Leu Val Phe Ser Met Ala Ile Gly Leu Phe385 390 395 400Phe Gly Tyr Tyr Pro Ala Asn Lys Ala Ala Lys Leu Asp Pro Ile Asp

405 410 415Ala Leu Arg Tyr Glu

420<210>361<211>1815<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1792)<223>RXN02096<400>361cgcttcgacg acctcaccca cagcgatatc cgcaggaatc tcatcgcggt ttttgatgag 60ccgttcttgt actcctcctc cataccgcga gaacatctcg atg ggt ttg gat gtc 115

Met Gly Leu Asp Val

1 5agt gat gag cag atc gaa cac gca gcc agg ctt gcc cag gct cat gat 163Ser Asp Glu Gln Ile Glu His Ala Ala Arg Leu Ala Gln Ala His Asp

10 15 20ttt atc gat cgc ctt cca aac aaa tac gag gaa gtc att ggc gaa cgc 211Phe Ile Asp Arg Leu Pro Asn Lys Tyr Glu Glu Val Ile Gly Glu Arg

25 30 35ggc ctg acg ctt tct ggt ggt caa cgc caa cgc atc gcc ctc gca cgg 259Gly Leu Thr Leu Ser Gly Gly Gln Arg Gln Arg Ile Ala Leu Ala Arg

40 45 50gct ttc ctg gcg cat ccc aaa gtg ttg gtg ctt gat gat gcc acc tct 307Ala Phe Leu Ala His Pro Lys Val Leu Val Leu Asp Asp Ala Thr Ser

55 60 65gcc att gat gcc tcc act gag gac cgc att ttc cag gcc ttg cgc gaa 355Ala Ile Asp Ala Ser Thr Glu Asp Arg Ile Phe Gln Ala Leu Arg Glu 70 75 80 85gaa ctg cac gat gtc acc att ttg atc atc gcg cac cgc cac tcc act 403Glu Leu His Asp Val Thr Ile Leu Ile Ile Ala His Arg His Ser Thr

90 95 100ttg gag ctc ggc gat cgg gtt ggt ctg gtc gaa gat gga cgg gta aca 451Leu Glu Leu Gly Asp Arg Val Gly Leu Val Glu Asp Gly Arg Val Thr

105110 115gca ctg gga ccg ttg agt gag atg cgt gat cac gct cgt ttc tcg cat 499Ala Leu Gly Pro Leu Ser Glu Met Arg Asp His Ala Arg Phe Ser His

120 125 130ctg atg gct ctt gat ttc cag gat tct cac gat ccg gaa ttc acc ctc 547Leu Met Ala Leu Asp Phe Gln Asp Ser His Asp Pro Glu Phe Thr Leu

135 140 145gac aac ggt tca cta ccc agc caa gag caa ttg tgg ccg gag gtc tcc 595Asp Asn Gly Ser Leu Pro Ser Gln Glu Gln Leu Trp Pro Glu Val Ser150 155 160 165aca gaa aag cag tac aag att ctt gcg cct gcc cct ggt cga ggc cgt 643Thr Glu Lys Gln Tyr Lys Ile Leu Ala Pro Ala Pro Gly Arg Gly Arg

170 175 180ggc atg tcc atg cca gca acc cct gag ctg ctc gcc cag att gag gcg 691Gly Met Ser Met Pro Ala Thr Pro Glu Leu Leu Ala Gln Ile Glu Ala

185 190 195ctg cca gca gca acg gaa gaa aca cga gtt gat gcc ggg agg cta cgc 739Leu Pro Ala Ala Thr Glu Glu Thr Arg Val Asp Ala Gly Arg Leu Arg

200 205 210acc agt acc tcc ggt ttc aaa ttg ctc agt tta ttc aag cag gtc cgt 787Thr Ser Thr Ser Gly Phe Lys Leu Leu Ser Leu Phe Lys Gln Val Arg

215 220 225tgg ctc gtc gtc gcg gtc atc gcg ttg ttg ctg gtg ggc gta gcc gcc 835Trp Leu Val Val Ala Val Ile Ala Leu Leu Leu Val Gly Val Ala Ala230 235 240 245gat cta gca ttt cca aca ctg atg cgc gca gcc atc gac aac ggt gtg 883Asp Leu Ala Phe Pro Thr Leu Met Arg Ala Ala Ile Asp Asn Gly Val

250 255 260caa gca caa agc acc tcc acg ttg tgg tgg atc gcc atc gca ggc agc 931Gln Ala Gln Ser Thr Ser Thr Leu Trp Trp IleAla Ile Ala Gly Ser

265 270 275gta gta gtc ctt ctg tcc tgg gcc gcc gcc gcg atc aac acg att atc 979Val Val Val Leu Leu Ser Trp Ala Ala Ala Ala Ile Asn Thr Ile Ile

280 285 290acg gca cgc acc ggt gaa cgg ctg ctt tac ggc ttg cgt ctg cgc tca 1027Thr Ala Arg Thr Gly Glu Arg Leu Leu Tyr Gly Leu Arg Leu Arg Ser

295 300 305ttt gtg cat cta ttg cgc ctg tcc atg agc tat ttc gaa cgc acc atg 1075Phe Val His Leu Leu Arg Leu Ser Met Ser Tyr Phe Glu Arg Thr Met310 315 320 325tcc ggc cgc atc atg acg cgc atg acc acc gac atc gac aac ctc tcg 1123Ser Gly Arg Ile Met Thr Arg Met Thr Thr Asp Ile Asp Asn Leu Ser

330 335 340tcc ttc ctc caa tca ggt ctg gcg caa aca gtt gtc tct gtg ggc acg 1171Ser Phe Leu Gln Ser Gly Leu Ala Gln Thr Val Val Ser Val Gly Thr

345 350 355ctc atc ggt gtg gtc acc atg ctc gcc atc acc gac gca caa cta gca 1219Leu Ile Gly Val Val Thr Met Leu Ala Ile Thr Asp Ala Gln Leu Ala

360 365 370ctc gtt gcg ctg tcc gtg gtg ccg atc atc atc gtg ctc act ctc att 1267Leu Val Ala Leu Ser Val Val Pro Ile Ile Ile Val Leu Thr Leu Ile

375 380 385ttc cga cgc atc agc tcc agg ctg tac acc gct tca cgc gag caa gcc 1315Phe Arg Arg Ile Ser Ser Arg Leu Tyr Thr Ala Ser Arg Glu Gln Ala390 395 400 405agc cag gtc aac gcg gta ttc cac gag tcc atc gcc ggt tta cgc acc 1363Ser Gln Val Asn Ala Val Phe His Glu Ser Ile Ala Gly Leu Arg Thr

410 415 420gcg cag atg cac cgc atg gaa gac caa gtc ttt gac aat tat gcg ggc 1411Ala Gln Met His Arg Met Glu Asp Gln Val Phe Asp Asn Tyr Ala Gly

425 430 435gaa gca gag gaa ttc cga cgc ctg cgt gtg aaa tcc cag acg gcc atc 1459Glu Ala Glu Glu Phe Arg Arg Leu Arg Val Lys Ser Gln Thr Ala Ile

440 445 450gcc atc tac ttc ccc ggc ctt ggc gcg ctc tct gaa atc gcc cag gca 1507Ala Ile Tyr Phe Pro Gly Leu Gly Ala Leu Ser Glu Ile Ala Gln Ala

455 460 465ctc gtc ctc ggt ttc ggc gca ctg caa gta acg cgc ggc gac atc tcc 1555Leu Val Leu Gly Phe Gly Ala Leu Gln Val Thr Arg Gly Asp Ile Ser470 475 480 485acc ggc gta ctc gtg gca ttc gtg ctg tac atg ggc ctg atg ttc ggc 1603Thr Gly Val Leu Val Ala Phe Val Leu Tyr Met Gly Leu Met Phe Gly

490 495 500ccc atc caa caa cta agc caa atc ttc gac tcc tac caa caa gcc gcc 1651Pro Ile Gln Gln Leu Ser Gln Ile Phe Asp Ser Tyr Gln Gln Ala Ala

505 510 515gtc ggc ttc cgt cgc atc acc gaa ctg ctc gca acg cag ccc agc gtc 1699Val Gly Phe Arg Arg Ile Thr Glu Leu Leu Ala Thr Gln Pro Ser Val

520 525 530cag atc tgg gca cca aca ggc acg cta ggc agg ctg cca cgc agc ctt 1747Gln Ile Trp Ala Pro Thr Gly Thr Leu Gly Arg Leu Pro Arg Ser Leu

535540545 tat tgc ttg acg acg tca cct tcg gct att cag acg atc cga tcc 1792Tyr Cys Leu Thr Thr Ser Pro Ser Ala Ile Gln Thr Ile Arg Ser 550555560 tagacacgt caccgtccag atc 1815<210>362<211>564<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>362Met Gly Leu Asp Val Ser Asp Glu Gln Ile Glu His AlaAla Arg Leu 151015 Ala Gln Ala His Asp Phe Ile Asp Arg Leu Pro Asn Lys Tyr Glu Glu

20 25 30Val Ile Gly Glu Arg Gly Leu Thr Leu Ser Gly Gly Gln Arg Gln Arg

35 40 45Ile Ala Leu Ala Arg Ala Phe Leu Ala His Pro Lys Val Leu Val Leu

50 55 60Asp Asp Ala Thr Ser Ala Ile Asp Ala Ser Thr Glu Asp Arg Ile Phe 65 70 75 80Gln Ala Leu Arg Glu Glu Leu His Asp Val Thr Ile Leu Ile Ile Ala

85 90 95His Arg His Ser Thr Leu Glu Leu Gly Asp Arg Val Gly Leu Val Glu

100 105 110Asp Gly Arg Val Thr Ala Leu Gly Pro Leu Ser Glu Met Arg Asp His

115 120 125Ala Arg Phe Ser His Leu Met Ala Leu Asp Phe Gln Asp Ser His Asp

130 135 140Pro Glu Phe Thr Leu Asp Asn Gly Ser Leu Pro Ser Gln Glu Gln Leu145 150 155 160Trp Pro Glu Val Ser Thr Glu Lys Gln Tyr Lys Ile Leu Ala Pro Ala

165 170 175Pro Gly Arg Gly Arg Gly Met Ser Met Pro Ala Thr Pro Glu Leu Leu

180 185 190Ala Gln Ile Glu Ala Leu Pro Ala Ala Thr Glu Glu Thr Arg Val Asp

195 200 205Ala Gly Arg Leu Arg Thr Ser Thr Ser Gly Phe Lys Leu Leu Ser Leu

210 215 220Phe Lys Gln Val Arg Trp Leu Val Val Ala Val Ile Ala Leu Leu Leu225 230 235 240ValGly Val Ala Ala Asp Leu Ala Phe Pro Thr Leu Met Arg Ala Ala

245 250 255Ile Asp Asn Gly Val Gln Ala Gln Ser Thr Ser Thr Leu Trp Trp Ile

260 265 270Ala Ile Ala Gly Ser Val Val Val Leu Leu Ser Trp Ala Ala Ala Ala

275 280 285Ile Asn Thr Ile Ile Thr Ala Arg Thr Gly Glu Arg Leu Leu Tyr Gly

290 295 300Leu Arg Leu Arg Ser Phe Val His Leu Leu Arg Leu Ser Met Ser Tyr305 310 315 320Phe Glu Arg Thr Met Ser Gly Arg Ile Met Thr Arg Met Thr Thr Asp

325 330 335Ile Asp Asn Leu Ser Ser Phe Leu Gln Ser Gly Leu Ala Gln Thr Val

340 345 350Val Ser Val Gly Thr Leu Ile Gly Val Val Thr Met Leu Ala Ile Thr

355 360 365Asp Ala Gln Leu Ala Leu Val Ala Leu Ser Val Val Pro Ile Ile Ile

370 375 380Val Leu Thr Leu Ile Phe Arg Arg Ile Ser Ser Arg Leu Tyr Thr Ala385 390 395 400Ser Arg Glu Gln Ala Ser Gln Val Asn Ala Val Phe His Glu Ser Ile

405 410 415Ala Gly Leu Arg Thr Ala Gln Met His Arg Met Glu Asp Gln Val Phe

420 425 430Asp Asn Tyr Ala Gly Glu Ala Glu Glu Phe Arg Arg Leu Arg Val Lys

435 440 445Ser Gln Thr Ala Ile Ala Ile Tyr Phe Pro Gly Leu Gly Ala Leu Ser

450 455 460Glu Ile Ala Gln Ala LeuVal Leu Gly Phe Gly Ala Leu Gln Val Thr465 470 475 480Arg Gly Asp Ile Ser Thr Gly Val Leu Val Ala Phe Val Leu Tyr Met

485 490 495Gly Leu Met Phe Gly Pro Ile Gln Gln Leu Ser Gln Ile Phe Asp Ser

500 505 510Tyr Gln Gln Ala Ala Val Gly Phe Arg Arg Ile Thr Glu Leu Leu Ala

515 520 525Thr Gln Pro Ser Val Gln Ile Trp Ala Pro Thr Gly Thr Leu Gly Arg

530535540 Leu Pro Arg Ser Leu Tyr Cys Leu Thr Thr Ser Pro Ser Ala Ile Gln 545550555560 Thr Ile Arg Ser<210>363<211>1203<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1180)<223>RXN00412<400>363cttttgacga acaccacgtc gcgtacgctt cctcggggcg ttaaactatt tgtcttccag 60cttttgtccc ccgacttttg tacgaatcga ggacaccgtc gtg tca cac acc gcg 115

Val Ser His Thr Ala

1 5tcc aca ccg acg cca gag gaa tac tcc gcg cag caa ccc agc acc cag 163Ser Thr Pro Thr Pro Glu Glu Tyr Ser Ala Gln Gln Pro Ser Thr Gln

10 15 20ggc act cgc gtt gag ttc cgc ggc ata acc aaa gtc ttt agc aac aat 211Gly Thr Arg Val Glu Phe Arg Gly Ile Thr Lys Val Phe Ser Asn Asn

25 30 35aaa tct gct aaa acc acc gcg ctt gat aat gtc act ctc acc gta gaa 259Lys Ser Ala Lys Thr Thr Ala Leu Asp Asn Val Thr Leu Thr Val Glu

40 45 50ccc ggt gag gta atc ggc atc atc ggt tac tct ggc gcc ggc aag tcc 307Pro Gly Glu ValIle Gly Ile Ile Gly Tyr Ser Gly Ala Gly Lys Ser

55 60 65act ctt gtc cgc ctc atc aat ggc ctt gac tcc ccc acg agc ggt tcg 355Thr Leu Val Arg Leu Ile Asn Gly Leu Asp Ser Pro Thr Ser Gly Ser 70 75 80 85ttg ctg ctc aac ggc acc gac atc gtc gga atg ccc gag tct aag ctg 403Leu Leu Leu Asn Gly Thr Asp Ile Val Gly Met Pro Glu Ser Lys Leu

90 95 100cgt aaa ctg cgc agt aat atc ggc atg att ttc cag cag ttc aac ctg 451Arg Lys Leu Arg Ser Asn Ile Gly Met Ile Phe Gln Gln Phe Asn Leu

105 110 115ttc cag tcg cgt act gcg gct gga aat gtg gag tac ccg ctg gaa gtt 499Phe Gln Ser Arg Thr Ala Ala Gly Asn Val Glu Tyr Pro Leu Glu Val

120 125 130gcc aag atg gac aag gca gct cgt aaa gct cgc gtg caa gaa atg ctc 547Ala Lys Met Asp Lys Ala Ala Arg Lys Ala Arg Val Gln Glu Met Leu

135 140 145gag ttc gtc ggc ctg ggc gac aaa ggc aaa aac tac ccc gag cag ctg 595Glu Phe Val Gly Leu Gly Asp Lys Gly Lys Asn Tyr Pro Glu Gln Leu150 155 160 165tcg ggc ggc cag aag cag cgc gtc ggc att gcc cgt gca ctg gcc acc 643Ser Gly Gly Gln Lys Gln Arg Val Gly Ile Ala Arg Ala Leu Ala Thr

170 175 180aat cca acg ctt ttg ctt gcc gac gaa gcc acc tcc gct ttg gac cca 691Asn Pro Thr Leu Leu Leu Ala Asp Glu Ala Thr Ser Ala Leu Asp Pro

185 190 195gaa acc acc cat gaa gtt ctg gag ctg ctg cgc aag gta aac cgc gaa 739Glu Thr Thr His Glu Val Leu Glu Leu Leu Arg Lys Val Asn Arg Glu

200205 210ctg ggc atc acc atc gtt gtg atc acc cac gaa atg gaa gtt gtg cgt 787Leu Gly Ile Thr Ile Val Val Ile Thr His Glu Met Glu Val Val Arg

215 220 225tcc atc gca gac aag gtt gct gtg atg gaa tcc ggc aaa gtt gtg gaa 835Ser Ile Ala Asp Lys Val Ala Val Met Glu Ser Gly Lys Val Val Glu230 235 240 245tac ggc agc gtc tac gag gtg ttc tcc aat cca caa aca cag gtt gct 883Tyr Gly Ser Val Tyr Glu Val Phe Ser Asn Pro Gln Thr Gln Val Ala

250 255 260caa aag ttc gtg gcc acc gcg ctg cgt aac acc cca gac caa gtg gaa 931Gln Lys Phe Val Ala Thr Ala Leu Arg Asn Thr Pro Asp Gln Val Glu

265 270 275tcg gaa gat ctg ctt agc cat gag gga cgt ctg ttc acc att gat ctg 979Ser Glu Asp Leu Leu Ser His Glu Gly Arg Leu Phe Thr Ile Asp Leu

280 285 290act gaa acg tcc ggc ttc ttt gca gca acc gct cgt gct gcc gaa caa 1027Thr Glu Thr Ser Gly Phe Phe Ala Ala Thr Ala Arg Ala Ala Glu Gln

295 300 305ggt gct ttt gtc aac atc gtt cac ggt ggc gtg acc acc ttg caa cgc 1075Gly Ala Phe Val Asn Ile Val His Gly Gly Val Thr Thr Leu Gln Arg310 315 320 325caa tca ttt ggc aaa atg act gtt cga ctc acc ggc aac acc gct gcg 1123Gln Ser Phe Gly Lys Met Thr Val Arg Leu Thr Gly Asn Thr Ala Ala

330 335 340att gaa gag ttc tat caa acc ttg acc aag acc acg acc atc aag gag 1171Ile Glu Glu Phe Tyr Gln Thr Leu Thr Lys Thr Thr Thr Ile Lys Glu

345 350 355atc acc cga tgaacgagat gatcctcgca gct1203Ile Thr Arg

360<210>364<211>360<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>364Val Ser His Thr Ala Ser Thr Pro Thr Pro Glu Glu Tyr Ser Ala Gln 151015 Gln Pro Ser Thr Gln Gly Thr Arg Val Glu Phe Arg Gly Ile Thr Lys

20 25 30Val Phe Ser Asn Asn Lys Ser Ala Lys Thr Thr Ala Leu Asp Asn Val

35 40 45Thr Leu Thr Val Glu Pro Gly Glu Val Ile Gly Ile Ile Gly Tyr Ser

50 55 60Gly Ala Gly Lys Ser Thr Leu Val Arg Leu Ile Asn Gly Leu Asp Ser 65 70 75 80Pro Thr Ser Gly Ser Leu Leu Leu Asn Gly Thr Asp Ile Val Gly Met

85 90 95Pro Glu Ser Lys Leu Arg Lys Leu Arg Ser Asn Ile Gly Met Ile Phe

100 105 110Gln Gln Phe Asn Leu Phe Gln Ser Arg Thr Ala Ala Gly Asn Val Glu

115 120 125Tyr Pro Leu Glu Val Ala Lys Met Asp Lys Ala Ala Arg Lys Ala Arg

130 135 140Val Gln Glu Met Leu Glu Phe Val Gly Leu Gly Asp Lys Gly Lys Asn145 150 155 160Tyr Pro Glu Gln Leu Ser Gly Gly Gln Lys Gln Arg Val Gly Ile Ala

165 170 175Arg Ala Leu Ala Thr Asn Pro Thr Leu Leu Leu Ala Asp Glu Ala Thr

180 185 190Ser Ala Leu Asp Pro Glu Thr Thr His Glu Val Leu Glu Leu Leu Arg

195 200 205Lys Val Asn Arg Glu Leu Gly Ile Thr Ile Val Val Ile Thr His Glu

210 215 220Met Glu Val Val Arg Ser Ile Ala Asp Lys Val Ala Val Met Glu Ser225 230 235 240Gly Lys Val Val Glu Tyr Gly Ser Val Tyr Glu Val Phe Ser Asn Pro

245 250 255Gln Thr Gln Val Ala Gln Lys Phe Val Ala Thr Ala Leu Arg Asn Thr

260 265 270Pro Asp Gln Val Glu Ser Glu Asp Leu Leu Ser His Glu Gly Arg Leu

275 280 285Phe Thr Ile Asp Leu Thr Glu Thr Ser Gly Phe Phe Ala Ala Thr Ala

290 295 300Arg Ala Ala Glu Gln Gly Ala Phe Val Asn Ile Val His Gly Gly Val305 310 315 320Thr Thr Leu Gln Arg Gln Ser Phe Gly Lys Met Thr Val Arg Leu Thr

325 330 335Gly Asn Thr Ala Ala Ile Glu Glu Phe Tyr Gln Thr Leu Thr Lys Thr

340 345 350Thr Thr Ile Lys Glu Ile Thr Arg

355360<210>365<211>798<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (775)<223>RXN00411<400>365catttggcaa aatgactgtt cgactcaccg gcaacaccgc tgcgattgaa gagttctatc 60aaaccttgac caagaccacg accatcaagg agatcacccg atg aac gag atg atc 115

Met Asn Glu Met Ile

1 5ctc gca gct gac tgg aac cgg cta gga ccc acc ttc caa aca gcc atc 163Leu Ala Ala Asp Trp Asn Arg Leu Gly Pro Thr Phe Gln Thr Ala Ile

1015 20att gac acc ctg ttg atg gtc atc atc acc atg gtg gtg gct ggc tta 211Ile Asp Thr Leu Leu Met Val Ile Ile Thr Met Val Val Ala Gly Leu

25 30 35ctg ggt ctt gtc gtc ggc ctg ctg ctt tac acc acc cgc gct ggt gga 259Leu Gly Leu Val Val Gly Leu Leu Leu Tyr Thr Thr Arg Ala Gly Gly

40 45 50atc ttg aag aac aag gtc atc tac acc att ttg aat gtg ctg gtg aac 307Ile Leu Lys Asn Lys Val Ile Tyr Thr Ile Leu Asn Val Leu Val Asn

55 60 65ttt gtt cga ccc atc cca ttc att att ttg atc gcc gcc atc aag cca 355Phe Val Arg Pro Ile Pro Phe Ile Ile Leu Ile Ala Ala Ile Lys Pro 70 75 80 85cta acg gtc gcc gtc atg ggc acc tcc atc ggc cga gat gcc ggc atc 403Leu Thr Val Ala Val Met Gly Thr Ser Ile Gly Arg Asp Ala Gly Ile

90 95 100ttc gtc atg gtt gtc gca gcg att ttc tct gtg gct cga atc gtg gag 451Phe Val Met Val Val Ala Ala Ile Phe Ser Val Ala Arg Ile Val Glu

105 110 115caa aac ttg gtc tcc att gat cct ggt gtc atc gag gca gct cgc tcc 499Gln Asn Leu Val Ser Ile Asp Pro Gly Val Ile Glu Ala Ala Arg Ser

120 125 130atg ggt gcg tcc ccg atg cgc atc atc gcc acc gtg atc att cca gaa 547Met Gly Ala Ser Pro Met Arg Ile Ile Ala Thr Val Ile Ile Pro Glu

135 140 145gca ctt gga cca ttg gtt ctg ggt tac acc ttc ctg ttc atc gcg atc 595Ala Leu Gly Pro Leu Val Leu Gly Tyr Thr Phe Leu Phe Ile Ala Ile150 155 160 165gtc gat atg tcc gca atg gtc ggc tac atc ggt ggc ggt ggt ctt ggt 643Val Asp MetSer Ala Met Val Gly Tyr Ile Gly Gly Gly Gly Leu Gly

170 175 180gac ttc gcc att gtt tac ggc tac cgc gcc ttc gac aac gaa gtt atg 691Asp Phe Ala Ile Val Tyr Gly Tyr Arg Ala Phe Asp Asn Glu Val Met

185 190 195tac gtt gcc gtc ctg gtt atc gtc atc atc gtg cag gca gcc cag ctt 739Tyr Val Ala Val Leu Val Ile Val Ile Ile Val Gln Ala Ala Gln Leu

200 205 210ctg ggc aat tgg ctg tcc aag aag atc atg cgc cgc taaacctctt 785Leu Gly Asn Trp Leu Ser Lys Lys Ile Met Arg Arg

215220225 gcatagaaaa acc 798<210>366<211>225<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>366Met Asn Glu Met Ile Leu Ala Ala Asp Trp Asn Arg Leu Gly Pro Thr 151015 Phe Gln Thr Ala Ile Ile Asp Thr Leu Leu Met Val Ile Ile Thr Met

20 25 30Val Val Ala Gly Leu Leu Gly Leu Val Val Gly Leu Leu Leu Tyr Thr

35 40 45Thr Arg Ala Gly Gly Ile Leu Lys Asn Lys Val Ile Tyr Thr Ile Leu

50 55 60Asn Val Leu Val Asn Phe Val Arg Pro Ile Pro Phe Ile Ile Leu Ile 65 70 75 80Ala Ala Ile Lys Pro Leu Thr Val Ala Val Met Gly Thr Ser Ile Gly

85 90 95Arg Asp Ala Gly Ile Phe Val Met Val Val Ala Ala Ile Phe Ser Val

100 105 110Ala Arg Ile Val Glu Gln Asn Leu Val Ser Ile Asp Pro Gly Val Ile

115 120 125Glu Ala Ala Arg Ser Met Gly Ala Ser Pro Met ArgIle Ile Ala Thr

130 135 140Val Ile Ile Pro Glu Ala Leu Gly Pro Leu Val Leu Gly Tyr Thr Phe145 150 155 160Leu Phe Ile Ala Ile Val Asp Met Ser Ala Met Val Gly Tyr Ile Gly

165 170 175Gly Gly Gly Leu Gly Asp Phe Ala Ile Val Tyr Gly Tyr Arg Ala Phe

180 185 190Asp Asn Glu Val Met Tyr Val Ala Val Leu Val Ile Val Ile Ile Val

195 200 205Gln Ala Ala Gln Leu Leu Gly Asn Trp Leu Ser Lys Lys Ile Met Arg

210215220 Arg225<210>367<211>852<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (829)<223>RXN02614<400>367tcattgtata cgccaccctc ggtctgctgt ctgaagcgct gatcagagct tgggaacgtc 60acaccttccg ctaccgaaac gcataagaaa gttgctcgcc atg act gcc aca ttg 115

Met Thr Ala Thr Leu

1 5tca ctc aaa ccc gca gcc act gtc cgt gga ttg cgc aaa tca tac gga 163Ser Leu Lys Pro Ala Ala Thr Val Arg Gly Leu Arg Lys Ser Tyr Gly

10 15 20act aaa gaa gtc ctc caa gga atc gac ctc acc atc aac tgc ggc gaa 211Thr Lys Glu Val Leu Gln Gly Ile Asp Leu Thr Ile Asn Cys Gly Glu

25 30 35gta acc gcg ctg atc gga cgc tca ggt tca gga aaa tcc acc atc ctg 259Val Thr Ala Leu Ile Gly Arg Ser Gly Ser Gly Lys Ser Thr Ile Leu

40 45 50cgc gtg ttg gcg ggc cta tct aaa gag cat tcc ggc tct gta gaa att 307Arg Val Leu Ala Gly Leu Ser Lys Glu His Ser Gly Ser Val Glu Ile

55 60 65tcc gga aac ccg gcc gtt gcc ttc caa gag cct cgc ctg ttg ccg tgg 355Ser Gly Asn Pro Ala Val Ala Phe Gln Glu Pro Arg Leu Leu Pro Trp 70 75 80 85aaa acg gtg ctc gat aat gtg acc ttt ggc ctc aac cgc act gat att 403Lys Thr Val Leu Asp Asn Val Thr Phe Gly Leu Asn Arg Thr Asp Ile

90 95 100tcc tgg tca gaa gca caa gaa cgc gcc tcg gca ctg ctt gca gaa gtc 451Ser Trp Ser Glu Ala Gln Glu Arg Ala Ser Ala Leu Leu Ala Glu Val

105 110 115aaa ctt ccc gac tcc gac gcc gcc tgg ccc ctc acg ctc tcc ggc ggc 499Lys Leu Pro Asp Ser Asp Ala Ala Trp Pro Leu Thr Leu Ser Gly Gly

120 125 130caa gcc cag cgc gtc tcc ctt gcg cga gcg ctc atc tcc gag cca gag 547Gln Ala Gln Arg Val Ser Leu Ala Arg Ala Leu Ile Ser Glu Pro Glu

135 140 145ctt ttg ctt ctc gac gaa ccc ttc ggc gcc ctc gat gct ctg aca aga 595Leu Leu Leu Leu Asp Glu Pro Phe Gly Ala Leu Asp Ala Leu Thr Arg150 155 160 165ctg aca gcc caa gac ctg ctg ctc aaa acc gtg aac acc cga aac ttg 643Leu Thr Ala Gln Asp Leu Leu Leu Lys Thr Val Asn Thr Arg Asn Leu

170 175 180gga gtt ctg ctg gtc acc cat gat gtt tcc gag gcc atc gcc ctg gcc 691Gly Val Leu Leu Val Thr His Asp Val Ser Glu Ala Ile Ala Leu Ala

185 190 195gac cac gtc ctt ctt ctt gac gac ggc gcc atc aca cac agt ttg act 739Asp His Val Leu Leu Leu Asp Asp Gly Ala Ile Thr His Ser Leu Thr

200205 210gta gat atc ccc ggc gat cgc cgc acc cac ccc tcc ttt gcc tcc tac 787Val Asp Ile Pro Gly Asp Arg Arg Thr His Pro Ser Phe Ala Ser Tyr

215220225 acc gct caa ctc ctt gag tgg ctc gaa atc acc aca cct gcc 829Thr Ala Gln Leu Leu Glu Trp Leu Glu Ile Thr Thr Pro Ala 230235240 tagaagaaa tcatgaaatt taa 852<210>368<211>243<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>368Met Thr Ala Thr Leu Ser Leu Lys Pro Ala Ala Thr Val Arg Gly Leu 151015 Arg Lys Ser Tyr Gly Thr Lys Glu Val Leu Gln Gly Ile Asp Leu Thr

20 25 30Ile Asn Cys Gly Glu Val Thr Ala Leu Ile Gly Arg Ser Gly Ser Gly

35 40 45Lys Ser Thr Ile Leu Arg Val Leu Ala Gly Leu Ser Lys Glu His Ser

50 55 60Gly Ser Val Glu Ile Ser Gly Asn Pro Ala Val Ala Phe Gln Glu Pro 65 70 75 80Arg Leu Leu Pro Trp Lys Thr Val Leu Asp Asn Val Thr Phe Gly Leu

85 90 95Asn Arg Thr Asp Ile Ser Trp Ser Glu Ala Gln Glu Arg Ala Ser Ala

100 105 110Leu Leu Ala Glu Val Lys Leu Pro Asp Ser Asp Ala Ala Trp Pro Leu

115 120 125Thr Leu Ser Gly Gly Gln Ala Gln Arg Val Ser Leu Ala Arg Ala Leu

130 135 140Ile Ser Glu Pro Glu Leu Leu Leu Leu Asp Glu Pro Phe Gly Ala Leu145 150 155 160Asp Ala Leu Thr Arg Leu Thr Ala Gln Asp Leu Leu Leu Lys Thr Val

165 170 175Asn Thr Arg Asn Leu Gly Val Leu Leu Val Thr His Asp Val Ser Glu

180 185 190Ala Ile Ala Leu Ala Asp His Val Leu Leu Leu Asp Asp Gly Ala Ile

195 200 205Thr His Ser Leu Thr Val Asp Ile Pro Gly Asp Arg Arg Thr His Pro

210215220 Ser Phe Ala Ser Tyr Thr Ala Gln Leu Leu Glu Trp Leu Glu Ile Thr 225230235240 Thr Pro Ala<210>369<211>1080<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1057)<223>RXN02613<400>369agatatcccc ggcgatcgcc gcacccaccc ctcctttgcc tcctacaccg ctcaactcct 60tgagtggctc gaaatcacca cacctgccta gaaagaaatc atg aaa ttt aag aaa 115

Met Lys Phe Lys Lys

1 5atc gcc ctc gtt ctc gcc ttc ggt cta ggc ctt gca tcc tgc tca tca 163Ile Ala Leu Val Leu Ala Phe Gly Leu Gly Leu Ala Ser Cys Ser Ser

10 15 20gct tct ggc gat ccc gcc acc aac gcc gat gga tcc atc gat ctg agc 211Ala Ser Gly Asp Pro Ala Thr Asn Ala Asp Gly Ser Ile Asp Leu Ser

25 30 35aaa gta acc ctt aac atc ggt gat caa atc gcc gga aca gaa caa gtg 259Lys Val Thr Leu Asn Ile Gly Asp Gln Ile Ala Gly Thr Glu Gln Val

40 45 50ctc caa gct tca ggg gag cta gat gat gtc cct tat aaa atc gaa tgg 307Leu Gln Ala Ser Gly Glu Leu Asp Asp Val Pro Tyr Lys Ile Glu Trp

55 60 65tca tca ttt acc tct gga cca ccc caa atc gaa gca tta aac gca ggt 355Ser Ser Phe Thr Ser Gly Pro Pro Gln Ile Glu Ala Leu Asn Ala Gly 70 7580 85caa att gat ttc gcg atc acc gga aac acc cca ccg atc atc ggc ggc 403Gln Ile Asp Phe Ala Ile Thr Gly Asn Thr Pro Pro Ile Ile Gly Gly

90 95 100ccc acc aac acc aaa gtg gtc tcc gcc tac aac aac gat gct tta ggt 451Pro Thr Asn Thr Lys Val Val Ser Ala Tyr Asn Asn Asp Ala Leu Gly

105 110 115gat gtc atc ttg gtc gcc ccg gat tct tca ata acc tcg gtg gct gac 499Asp Val Ile Leu Val Ala Pro Asp Ser Ser Ile Thr Ser Val Ala Asp

120 125 130ctt gct gga aag aaa gtg gct gtc gcc cgc gga tcc agc gcc cac gga 547Leu Ala Gly Lys Lys Val Ala Val Ala Arg Gly Ser Ser Ala His Gly

135 140 145cac ctc atc caa caa cta gaa aaa gca ggc gtg agc gtt gac gac gta 595His Leu Ile Gln Gln Leu Glu Lys Ala Gly Val Ser Val Asp Asp Val150 155 160 165gaa atc aac ctc ctc caa ccc tcc gac gcc aaa gcc gct ttc caa aac 643Glu Ile Asn Leu Leu Gln Pro Ser Asp Ala Lys Ala Ala Phe Gln Asn

170 175 180ggc cag gta gat gcg tgg gca gtg tgg gat ccc tac agc tca cag gcg 691Gly Gln Val Asp Ala Trp Ala Val Trp Asp Pro Tyr Ser Ser Gln Ala

185 190 195gaa ctg gaa gga gct caa gtt ttg gtc agg gga gcg gga ctg gtc agt 739Glu Leu Glu Gly Ala Gln Val Leu Val Arg Gly Ala Gly Leu Val Ser

200 205 210ggg cat gga ttt ggt gtc gca agt gat gaa gcg ctc gat gac ccc gca 787Gly His Gly Phe Gly Val Ala Ser Asp Glu Ala Leu Asp Asp Pro Ala

215 220 225aag gaa gcc gcc ttg gca gat ttc ctc gat cgc gtg gccgac tct tat 835Lys Glu Ala Ala Leu Ala Asp Phe Leu Asp Arg Val Ala Asp Ser Tyr230 235 240 245gaa tgg gct gaa gac aac acc gat gaa tgg gcg acg att ttc agc caa 883Glu Trp Ala Glu Asp Asn Thr Asp Glu Trp Ala Thr Ile Phe Ser Gln

250 255 260gaa tcc ggc ttt gat ccg gag gcc tct caa ctg aac acc cgc agc ctg 931Glu Ser Gly Phe Asp Pro Glu Ala Ser Gln Leu Asn Thr Arg Ser Leu

265 270 275cgc cat cag gtg ccg ctc gac gag tcc gtc aac acc tat cag aac gcg 979Arg His Gln Val Pro Leu Asp Glu Ser Val Asn Thr Tyr Gln Asn Ala

280 285 290ctt atc gac gct ttc gtc tcc gcg ggt ctc gtt gag gac ttt aat ttc 1027Leu Ile Asp Ala Phe Val Ser Ala Gly Leu Val Glu Asp Phe Asn Phe

295300305 gag gac acc gta gac acc cga ttt gag ggc taagtatgtc tgagtatggc 1077Glu Asp Thr Val Asp Thr Arg Phe Glu Gly 310315 aaa1080<210>370<211>319<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>370Met Lys Phe Lys Lys Ile Ala Leu Val Leu Ala Phe Gly Leu Gly Leu 151015 Ala Ser Cys Ser Ser Ala Ser Gly Asp Pro Ala Thr Asn Ala Asp Gly

20 25 30Ser Ile Asp Leu Ser Lys Val Thr Leu Asn Ile Gly Asp Gln Ile Ala

35 40 45Gly Thr Glu Gln Val Leu Gln Ala Ser Gly Glu Leu Asp Asp Val Pro

50 55 60Tyr Lys Ile Glu Trp Ser Ser Phe Thr Ser Gly Pro Pro Gln Ile Glu 65 70 75 80Ala Leu Asn Ala Gly Gln Ile Asp Phe Ala Ile Thr Gly Asn Thr Pro

85 90 95Pro Ile Ile Gly Gly Pro Thr Asn Thr Lys Val Val Ser Ala Tyr Asn

100 105 110Asn Asp Ala Leu Gly Asp Val Ile Leu Val Ala Pro Asp Ser Ser Ile

115 120 125Thr Ser Val Ala Asp Leu Ala Gly Lys Lys Val Ala Val Ala Arg Gly

130 135 140Ser Ser Ala His Gly His Leu Ile Gln Gln Leu Glu Lys Ala Gly Val145 150 155 160Ser Val Asp Asp Val Glu Ile Asn Leu Leu Gln Pro Ser Asp Ala Lys

165 170 175Ala Ala Phe Gln Asn Gly Gln Val Asp Ala Trp Ala Val Trp Asp Pro

180 185 190Tyr Ser Ser Gln Ala Glu Leu Glu Gly Ala Gln Val Leu Val Arg Gly

195 200 205Ala Gly Leu Val Ser Gly His Gly Phe Gly Val Ala Ser Asp Glu Ala

210 215 220Leu Asp Asp Pro Ala Lys Glu Ala Ala Leu Ala Asp Phe Leu Asp Arg225 230 235 240Val Ala Asp Ser Tyr Glu Trp Ala Glu Asp Asn Thr Asp Glu Trp Ala

245 250 255Thr Ile Phe Ser Gln Glu Ser Gly Phe Asp Pro Glu Ala Ser Gln Leu

260 265 270Asn Thr Arg Ser Leu Arg His Gln Val Pro Leu Asp Glu Ser Val Asn

275 280 285Thr Tyr Gln Asn Ala Leu Ile Asp Ala Phe Val Ser Ala Gly Leu Val

290295300 Glu Asp Phe Asn Phe Glu Asp Thr Val Asp Thr Arg Phe Glu Gly 305310315<210>371<211>1698<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1675)<223>RXN00368<400>371ttcttccaaa acgcaatgaa ctagttttcc tatgcagtta tctccttcaa atacgtcgac 60gcagcgcttt cacatctctg cgttgacgtc tttgtctttc atg cgt ctg ggt gtg 115

Met Arg Leu Gly Val

1 5tgg ctg att gtc gcg ggg ttg ttt atc act ccg ttg gcg ctg gtg gtg 163Trp Leu Ile Val Ala Gly Leu Phe Ile Thr Pro Leu Ala Leu Val Val

10 15 20ggc ttg gcg ttg gga ggc aat cag ttt cct gct ctg tgg gat tcc gga 211Gly Leu Ala Leu Gly Gly Asn Gln Phe Pro Ala Leu Trp Asp Ser Gly

25 30 35ttg ggc aaa gcc cta tgg aat tcc gcc tat aca aca gtg ctt tct gcg 259Leu Gly Lys Ala Leu Trp Asn Ser Ala Tyr Thr Thr Val Leu Ser Ala

40 45 50gtg ggc gcg acc att atc ggc acg atc atg gct ctc acg ctg gac cga 307Val Gly Ala Thr Ile Ile Gly Thr Ile Met Ala Leu Thr Leu Asp Arg

55 60 65act gat gtt ttc ggg cgc acc gcg ttg cgg tta ttt ttg tta tcc ccg 355Thr Asp Val Phe Gly Arg Thr Ala Leu Arg Leu Phe Leu Leu Ser Pro 70 75 80 85ctg ttg atc cct ccg ttt att ggg gct att gcg tgg ttg cag ctg ttc 403Leu Leu Ile Pro Pro Phe Ile Gly Ala Ile Ala Trp Leu Gln Leu Phe

90 95 100ggg aag aac cag ggc atc aac cgg ttt ttc ggc acg gaa gtg tgg gat 451Gly Lys Asn Gln Gly Ile Asn Arg Phe Phe Gly Thr Glu Val Trp Asp

105 110 115att tac ggc gct gat ggt gtg aca ttt ttg ttg att gtg cac tcc tat 499Ile Tyr Gly Ala Asp Gly Val Thr Phe Leu Leu Ile Val His Ser Tyr

120 125 130ccc act gtg tac atc att gtt tcg gca gct ctg agg caa ctt cct agt 547Pro Thr Val Tyr Ile Ile Val Ser Ala Ala Leu Arg Gln Leu Pro Ser

135 140 145gat ttg gag caa gct gca cgg atc gcg ggg gcg gat act ttt acg gtg 595Asp Leu Glu Gln Ala Ala Arg Ile Ala Gly Ala Asp Thr Phe Thr Val150 155 160 165ttg cgc acc atc aca ctc cca ctg ctc aaa cct gca ttg ttg tcg gcg 643Leu Arg Thr Ile Thr Leu Pro Leu Leu Lys Pro Ala Leu Leu Ser Ala

170 175 180ttt act ctt acc aca gtg gcg aac ctc gcc gac ttt ggc att cca gct 691Phe Thr Leu Thr Thr Val Ala Asn Leu Ala Asp Phe Gly Ile Pro Ala

185 190 195ctg ttg gga tcg cca gcg cgt ttt gaa acc tta gcc acc atg att tat 739Leu Leu Gly Ser Pro Ala Arg Phe Glu Thr Leu Ala Thr Met Ile Tyr

200 205 210cgc ttc atg gaa tcc ggc acc gtg agc aat cca ttg cag gtg gta tcc 787Arg Phe Met Glu Ser Gly Thr Val Ser Asn Pro Leu Gln Val Val Ser

215 220 225acc att ggc atc gtg ttg ttg ttc ctg gga atc gca gca gta acc gcg 835Thr Ile Gly Ile Val Leu Leu Phe Leu Gly Ile Ala Ala Val Thr Ala230 235 240 245gat tat ctg gtg tct ttg tac gcg gca tca aag ttg caa gac gca gga 883Asp Tyr Leu Val Ser Leu Tyr Ala Ala Ser Lys Leu Gln Asp Ala Gly

250 255 260aca ccg cat cgc ttt act ctc aac aaa tca cga atc cca gtc agc gtg 931Thr Pro His Arg Phe Thr Leu Asn Lys Ser Arg Ile Pro Val Ser Val

265 270 275atc acg tgg atc atc gcg ttg atc atc acc gcc gcc ccg ctg ctg ggt 979Ile Thr Trp Ile Ile Ala Leu Ile Ile Thr Ala Ala Pro Leu Leu Gly

280 285 290ctg gca tac aga gca tta ctg cct gcc cca ggt gtg ccg ttc aac cta 1027Leu Ala Tyr Arg Ala Leu Leu Pro Ala Pro Gly Val Pro Phe Asn Leu

295 300 305gac aac atc acg ctc aac aac ttt gaa gca gca ctg agc aat cca cga 1075Asp Asn Ile Thr Leu Asn Asn Phe Glu Ala Ala Leu Ser Asn Pro Arg310 315 320 325gta atc gaa gga ttc agc aac tcc ctc atg tta tcc ctg ggt gca gcc 1123Val Ile Glu Gly Phe Ser Asn Ser Leu Met Leu Ser Leu Gly Ala Ala

330 335 340cta atc tgt ggg gtg ctg gga tgg ctg atc gga gtg ctc atc acc cga 1171Leu Ile Cys Gly Val Leu Gly Trp Leu Ile Gly Val Leu Ile Thr Arg

345 350 355acc cag cat ttc gcc aac gta ccg ttg aca ctc act gtg ctg ctt ccc 1219Thr Gln His Phe Ala Asn Val Pro Leu Thr Leu Thr Val Leu Leu Pro

360 365 370acc gca ctg ccg ggc atg atc atc ggc gtc ggc tgg ctc att ttg ggc 1267Thr Ala Leu Pro Gly Met Ile Ile Gly Val Gly Trp Leu Ile Leu Gly

375 380 385aga tac acc gga att tac aac aca cct tgg gtg att ttg ggt gca tat 1315Arg Tyr Thr Gly Ile Tyr Asn Thr Pro Trp Val Ile Leu Gly Ala Tyr390 395 400 405gtg tgt gct ttt acc gcg ctg gtt gtc caa gct gta cgc gga cca ctc 1363Val Cys Ala Phe Thr Ala Leu Val Val Gln Ala Val Arg Gly Pro Leu

410 415 420agt caa gca ccc gaa gca atc gaa gaa gcc gca cga atc agc ggc gca 1411Ser Gln Ala Pro Glu Ala Ile Glu Glu Ala Ala Arg Ile SerGly Ala

425 430 435ggc aga tta cga tcc atc atg gac acc acc gga gcg atg gca att ccc 1459Gly Arg Leu Arg Ser Ile Met Asp Thr Thr Gly Ala Met Ala Ile Pro

440 445 450gca gct ttc gcc ggc gca gtg ctg gtt gcg gta act gcg gtt cga gag 1507Ala Ala Phe Ala Gly Ala Val Leu Val Ala Val Thr Ala Val Arg Glu

455 460 465tta acc gtg tcc att ttg ctc atc gcg ccg ggc acc acc acc ctg ggt 1555Leu Thr Val Ser Ile Leu Leu Ile Ala Pro Gly Thr Thr Thr Leu Gly470 475 480 485gtg cag gtg ttc aat ttg cag cag gcg gga aat tac aat cag gca tcg 1603Val Gln Val Phe Asn Leu Gln Gln Ala Gly Asn Tyr Asn Gln Ala Ser

490 495 500gcg ttg tcg ttg atg ttt gcg att atc ggt atc gtg gcg ctc gcg ttg 1651Ala Leu Ser Leu Met Phe Ala Ile Ile Gly Ile Val Ala Leu Ala Leu

505 510 515acg gtg cgc agc cag aag gag ttt taggtgtcat cgatcaaatt gcg 1698Thr Val Arg Ser Gln Lys Glu Phe

520525<210>372<211>525<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>372Met Arg Leu Gly Val Trp Leu Ile Val Ala Gly Leu Phe Ile Thr Pro 151015 Leu Ala Leu Val Val Gly Leu Ala Leu Gly Gly Asn Gln Phe Pro Ala

20 25 30Leu Trp Asp Ser Gly Leu Gly Lys Ala Leu Trp Asn Ser Ala Tyr Thr

35 40 45Thr Val Leu Ser Ala Val Gly Ala Thr Ile Ile Gly Thr Ile Met Ala

50 55 60Leu Thr Leu Asp Arg Thr Asp Val Phe Gly Arg Thr Ala Leu Arg Leu 6570 75 80Phe Leu Leu Ser Pro Leu Leu Ile Pro Pro Phe Ile Gly Ala Ile Ala

85 90 95Trp Leu Gln Leu Phe Gly Lys Asn Gln Gly Ile Asn Arg Phe Phe Gly

100 105 110Thr Glu Val Trp Asp Ile Tyr Gly Ala Asp Gly Val Thr Phe Leu Leu

115 120 125Ile Val His Ser Tyr Pro Thr Val Tyr Ile Ile Val Ser Ala Ala Leu

130 135 140Arg Gln Leu Pro Ser Asp Leu Glu Gln Ala Ala Arg Ile Ala Gly Ala145 150 155 160Asp Thr Phe Thr Val Leu Arg Thr Ile Thr Leu Pro Leu Leu Lys Pro

165 170 175Ala Leu Leu Ser Ala Phe Thr Leu Thr Thr Val Ala Asn Leu Ala Asp

180 185 190Phe Gly Ile Pro Ala Leu Leu Gly Ser Pro Ala Arg Phe Glu Thr Leu

195 200 205Ala Thr Met Ile Tyr Arg Phe Met Glu Ser Gly Thr Val Ser Asn Pro

210 215 220Leu Gln Val Val Ser Thr Ile Gly Ile Val Leu Leu Phe Leu Gly Ile225 230 235 240Ala Ala Val Thr Ala Asp Tyr Leu Val Ser Leu Tyr Ala Ala Ser Lys

245 250 255Leu Gln Asp Ala Gly Thr Pro His Arg Phe Thr Leu Asn Lys Ser Arg

260 265 270Ile Pro Val Ser Val Ile Thr Trp Ile Ile Ala Leu Ile Ile Thr Ala

275 280 285Ala Pro Leu Leu Gly Leu Ala Tyr Arg Ala Leu Leu Pro Ala Pro Gly

290295 300Val Pro Phe Asn Leu Asp Asn Ile Thr Leu Asn Asn Phe Glu Ala Ala305 310 315 320Leu Ser Asn Pro Arg Val Ile Glu Gly Phe Ser Asn Ser Leu Met Leu

325 330 335Ser Leu Gly Ala Ala Leu Ile Cys Gly Val Leu Gly Trp Leu Ile Gly

340 345 350Val Leu Ile Thr Arg Thr Gln His Phe Ala Asn Val Pro Leu Thr Leu

355 360 365Thr Val Leu Leu Pro Thr Ala Leu Pro Gly Met Ile Ile Gly Val Gly

370 375 380Trp Leu Ile Leu Gly Arg Tyr Thr Gly Ile Tyr Asn Thr Pro Trp Val385 390 395 400Ile Leu Gly Ala Tyr Val Cys Ala Phe Thr Ala Leu Val Val Gln Ala

405 410 415Val Arg Gly Pro Leu Ser Gln Ala Pro Glu Ala Ile Glu Glu Ala Ala

420 425 430Arg Ile Ser Gly Ala Gly Arg Leu Arg Ser Ile Met Asp Thr Thr Gly

435 440 445Ala Met Ala Ile Pro Ala Ala Phe Ala Gly Ala Val Leu Val Ala Val

450 455 460Thr Ala Val Arg Glu Leu Thr Val Ser Ile Leu Leu Ile Ala Pro Gly465 470 475 480Thr Thr Thr Leu Gly Val Gln Val Phe Asn Leu Gln Gln Ala Gly Asn

485 490 495Tyr Asn Gln Ala Ser Ala Leu Ser Leu Met Phe Ala Ile Ile Gly Ile

500 505 510Val Ala Leu Ala Leu Thr Val Arg Ser Gln Lys Glu Phe

515520525<210>373<211>602<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (579)<223>FRXA00368<400>373tcc ctc atg tta tcc ctg ggt gca gcc cta atc tgt ggg gtg ctg gga 48Ser Leu Met Leu Ser Leu Gly Ala Ala Leu Ile Cys Gly Val Leu Gly 151015 tgg ctg atc gga gtg ctc atc acc cga acc cag cat ttc gcc aac gta 96Trp Leu Ile Gly Val Leu Ile Thr Arg Thr Gln His Phe Ala Asn Val

20 25 30ccg ttg aca ctc act gtg ctg ctt ccc acc gca ctg ccg ggc atg atc 144Pro Leu Thr Leu Thr Val Leu Leu Pro Thr Ala Leu Pro Gly Met Ile

35 40 45atc ggc gtc ggc tgg ctc att ttg ggc aga tac acc gga att tac aac 192Ile Gly Val Gly Trp Leu Ile Leu Gly Arg Tyr Thr Gly Ile Tyr Asn

50 55 60aca cct tgg gtg att ttg ggt gca tat gtg tgt gct ttt acc gcg ctg 240Thr Pro Trp Val Ile Leu Gly Ala Tyr Val Cys Ala Phe Thr Ala Leu 65 70 75 80gtt gtc caa gct gta cgc gga cca ctc agt caa gca ccc gaa gca atc 288Val Val Gln Ala Val Arg Gly Pro Leu Ser Gln Ala Pro Glu Ala Ile

85 90 95gaa gaa gcc gca cga atc agc ggc gca ggc aga tta cga tcc atc atg 336Glu Glu Ala Ala Arg Ile Ser Gly Ala Gly Arg Leu Arg Ser Ile Met

100 105 110gac acc acc gga gcg atg gca att ccc gca gct ttc gcc ggc gca gtg 384Asp Thr Thr Gly Ala Met Ala Ile Pro Ala Ala Phe Ala Gly Ala Val

115 120 125ctg gtt gcg gta act gcg gtt cga gag tta acc gtg tcc att ttg ctc 432Leu Val Ala Val Thr Ala Val Arg Glu Leu Thr Val Ser Ile Leu Leu

130 135 140atc gcg ccg ggc acc acc acc ctg ggt gtg cag gtg ttc aat ttg cag 480Ile Ala Pro Gly Thr Thr Thr Leu Gly Val Gln Val Phe Asn Leu Gln145 150 155 160cag gcg gga aat tac aat cag gca tcg gcg ttg tcg ttg atg ttt gcg 528Gln Ala Gly Asn Tyr Asn Gln Ala Ser Ala Leu Ser Leu Met Phe Ala

165 170 175att atc ggt atc gtg gcg ctc gcg ttg acg gtg cgc agc cag aag gag 576Ile Ile Gly Ile Val Ala Leu Ala Leu Thr Val Arg Ser Gln Lys Glu

180185190 ttt taggtgtcat cgatcaaatt gcg 602Phe<210>374<211>193<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>374Ser Leu Met Leu Ser Leu Gly Ala Ala Leu Ile Cys Gly Val Leu Gly 151015 Trp Leu Ile Gly Val Leu Ile Thr Arg Thr Gln His Phe Ala Asn Val

20 25 30Pro Leu Thr Leu Thr Val Leu Leu Pro Thr Ala Leu Pro Gly Met Ile

35 40 45Ile Gly Val Gly Trp Leu Ile Leu Gly Arg Tyr Thr Gly Ile Tyr Asn

50 55 60Thr Pro Trp Val Ile Leu Gly Ala Tyr Val Cys Ala Phe Thr Ala Leu 65 70 75 80Val Val Gln Ala Val Arg Gly Pro Leu Ser Gln Ala Pro Glu Ala Ile

85 90 95Glu Glu Ala Ala Arg Ile Ser Gly Ala Gly Arg Leu Arg Ser Ile Met

100 105 110Asp Thr Thr Gly Ala Met Ala Ile Pro Ala Ala Phe Ala Gly Ala Val

115 120 125Leu Val Ala Val Thr Ala Val Arg Glu Leu Thr Val Ser Ile Leu Leu

130 135 140Ile Ala Pro Gly Thr Thr Thr Leu Gly Val Gln Val Phe AsnLeu Gln145 150 155 160Gln Ala Gly Asn Tyr Asn Gln Ala Ser Ala Leu Ser Leu Met Phe Ala

165 170 175Ile Ile Gly Ile Val Ala Leu Ala Leu Thr Val Arg Ser Gln Lys Glu

180185190 Phe<210>375<211>798<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (798)<223>FRXA00370<400>375ggc aaa gcc cta tgg aat tcc gcc tat aca aca gtg ctt tct gcg gtg 48Gly Lys Ala Leu Trp Asn Ser Ala Tyr Thr Thr Val Leu Ser Ala Val 151015 ggc gcg acc att atc ggc acg atc atg gct ctc acg ctg gac cga act 96Gly Ala Thr Ile Ile Gly Thr Ile Met Ala Leu Thr Leu Asp Arg Thr

20 25 30gat gtt ttc ggg cgc acc gcg ttg cgg tta ttt ttg tta tcc ccg ctg 144Asp Val Phe Gly Arg Thr Ala Leu Arg Leu Phe Leu Leu Ser Pro Leu

35 40 45ttg atc cct ccg ttt att ggg gct att gcg tgg ttg cag ctg ttc ggg 192Leu Ile Pro Pro Phe Ile Gly Ala Ile Ala Trp Leu Gln Leu Phe Gly

50 55 60aag aac cag ggc atc aac cgg ttt ttc ggc acg gaa gtg tgg gat att 240Lys Asn Gln Gly Ile Asn Arg Phe Phe Gly Thr Glu Val Trp Asp Ile 65 70 75 80tac ggc gct gat ggt gtg aca ttt ttg ttg att gtg cac tcc tat ccc 288Tyr Gly Ala Asp Gly Val Thr Phe Leu Leu Ile Val His Ser Tyr Pro

85 90 95act gtg tac atc att gtt tcg gca gct ctg agg caa ctt cct agt gat 336Thr Val Tyr Ile Ile Val Ser Ala Ala Leu Arg Gln Leu Pro Ser Asp

100 105 110ttg gag caa gct gca cgg atc gcg ggg gcg gat act ttt acg gtg ttg384Leu Glu Gln Ala Ala Arg Ile Ala Gly Ala Asp Thr Phe Thr Val Leu

115 120 125cgc acc atc aca ctc cca ctg ctc aaa cct gca ttg ttg tcg gcg ttt 432Arg Thr Ile Thr Leu Pro Leu Leu Lys Pro Ala Leu Leu Ser Ala Phe

130 135 140act ctt acc aca gtg gcg aac ctc gcc gac ttt ggc att cca gct ctg 480Thr Leu Thr Thr Val Ala Asn Leu Ala Asp Phe Gly Ile Pro Ala Leu145 150 155 160ttg gga tcg cca gcg cgt ttt gaa acc tta gcc acc atg att tat cgc 528Leu Gly Ser Pro Ala Arg Phe Glu Thr Leu Ala Thr Met Ile Tyr Arg

165 170 175ttc atg gaa tcc ggc acc gtg agc aat cca ttg cag gtg gta tcc acc 576Phe Met Glu Ser Gly Thr Val Ser Asn Pro Leu Gln Val Val Ser Thr

180 185 190att ggc atc gtg ttg ttg ttc ctg gga atc gca gca gta acc gcg gat 624Ile Gly Ile Val Leu Leu Phe Leu Gly Ile Ala Ala Val Thr Ala Asp

195 200 205tat ctg gtg tct ttg tac gcg gca tca aag ttg caa gac gca gga aca 672Tyr Leu Val Ser Leu Tyr Ala Ala Ser Lys Leu Gln Asp Ala Gly Thr

210 215 220ccg cat cgc ttt act ctc aac aaa tca cga atc cca gtc agc gtg atc 720Pro His Arg Phe Thr Leu Asn Lys Ser Arg Ile Pro Val Ser Val Ile225 230 235 240acg tgg atc atc gcg ttg atc atc acc gcc gcc ccg ctg ctg ggt ctg 768Thr Trp Ile Ile Ala Leu Ile Ile Thr Ala Ala Pro Leu Leu Gly Leu

245 250 255gca tac aga gca tta ctg cct gcc cca ggt 798Ala Tyr Arg Ala Leu Leu Pro Ala Pro Gly

260265<210>376<211>266<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>376Gly Lys Ala Leu Trp Asn Ser Ala Tyr Thr Thr Val Leu Ser Ala Val 151015 Gly Ala Thr Ile Ile Gly Thr Ile Met Ala Leu Thr Leu Asp Arg Thr

20 25 30Asp Val Phe Gly Arg Thr Ala Leu Arg Leu Phe Leu Leu Ser Pro Leu

35 40 45Leu Ile Pro Pro Phe Ile Gly Ala Ile Ala Trp Leu Gln Leu Phe Gly

50 55 60Lys Asn Gln Gly Ile Asn Arg Phe Phe Gly Thr Glu Val Trp Asp Ile 65 70 75 80Tyr Gly Ala Asp Gly Val Thr Phe Leu Leu Ile Val His Ser Tyr Pro

85 90 95Thr Val Tyr Ile Ile Val Ser Ala Ala Leu Arg Gln Leu Pro Ser Asp

100 105 110Leu Glu Gln Ala Ala Arg Ile Ala Gly Ala Asp Thr Phe Thr Val Leu

115 120 125Arg Thr Ile Thr Leu Pro Leu Leu Lys Pro Ala Leu Leu Ser Ala Phe

130 135 140Thr Leu Thr Thr Val Ala Asn Leu Ala Asp Phe Gly Ile Pro Ala Leu145 150 155 160Leu Gly Ser Pro Ala Arg Phe Glu Thr Leu Ala Thr Met Ile Tyr Arg

165 170 175Phe Met Glu Ser Gly Thr Val Ser Asn Pro Leu Gln Val Val Ser Thr

180 185 190Ile Gly Ile Val Leu Leu Phe Leu Gly Ile Ala Ala Val Thr Ala Asp

195 200 205Tyr Leu Val Ser Leu Tyr Ala Ala Ser Lys Leu Gln Asp Ala Gly Thr

210 215 220Pro His Arg Phe Thr Leu Asn Lys Ser Arg Ile Pro Val Ser Val Ile225 230 235 240Thr Trp Ile Ile Ala Leu Ile Ile Thr Ala Ala Pro Leu Leu Gly Leu

245 250 255Ala Tyr Arg Ala Leu Leu Pro Ala Pro Gly

260265<210>377<211>749<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (726)<223>RXN01285<400>377ctc aac gtc acc atc ccc gac aac acc ttc acc gcc atc atc ggc ccc 48Leu Asn Val Thr Ile Pro Asp Asn Thr Phe Thr Ala Ile Ile Gly Pro 151015 aac ggc tgc ggc aaa tcc acc ctg ctc cgc ggt ttc tcc cgc gtg ctc 96Asn Gly Cys Gly Lys Ser Thr Leu Leu Arg Gly Phe Ser Arg Val Leu

20 25 30aat ccg cag cac ggc aaa gtg ctt ctc gac ggt cgg caa ctc gat tca 144Asn Pro Gln His Gly Lys Val Leu Leu Asp Gly Arg Gln Leu Asp Ser

35 40 45ttc aag cct aaa gag atc gcc cga gaa cta ggc ctg ctg cca cag acc 192Phe Lys Pro Lys Glu Ile Ala Arg Glu Leu Gly Leu Leu Pro Gln Thr

50 55 60tcc atc gcc cca gaa ggc atc cgg gtt tac gat ctc atc gcg cgc ggg 240Ser Ile Ala Pro Glu Gly Ile Arg Val Tyr Asp Leu Ile Ala Arg Gly 65 70 75 80cgc gct ccc tac caa agc ctc ata caa caa tgg cgc acc tcc gac gaa 288Arg Ala Pro Tyr Gln Ser Leu Ile Gln Gln Trp Arg Thr Ser Asp Glu

85 90 95gac gcc gtc gcg caa gcg ctc gcc tcc acg aat ctc acc gaa ctt gca 336Asp Ala Val Ala Gln Ala Leu Ala Ser Thr Asn Leu Thr Glu Leu Ala

100 105 110gct cgc ctc gtc gat gaa ctc tcc ggt ggc cag cgc caacga gtg tgg 384Ala Arg Leu Val Asp Glu Leu Ser Gly Gly Gln Arg Gln Arg Val Trp

115 120 125gtg gcc atg ttg ctc gcc cag caa aca ccg atc atg ctt ctc gac gag 432Val Ala Met Leu Leu Ala Gln Gln Thr Pro Ile Met Leu Leu Asp Glu

130 135 140ccc acc acc ttc ctc gac atc gcc cac caa tac gaa ctc ttg gaa ttg 480Pro Thr Thr Phe Leu Asp Ile Ala His Gln Tyr Glu Leu Leu Glu Leu145 150 155 160ctg cgc gca ttc aac gag gcc ggg aaa act gtg gtc act gtg ctt cac 528Leu Arg Ala Phe Asn Glu Ala Gly Lys Thr Val Val Thr Val Leu His

165 170 175gat ctc aac caa gcc gcc cgc tac gcc gac cac ctc atc gtg atg aaa 576Asp Leu Asn Gln Ala Ala Arg Tyr Ala Asp His Leu Ile Val Met Lys

180 185 190gat ggg cac gta cat gcc acg ggc aca ccg gag gaa gtc tta act gcc 624Asp Gly His Val His Ala Thr Gly Thr Pro Glu Glu Val Leu Thr Ala

195 200 205gag atg gtt caa gga gtt ttt ggc ctg ccc tgc atc atc tcc cca gac 672Glu Met Val Gln Gly Val Phe Gly Leu Pro Cys Ile Ile Ser Pro Asp

210215220 ccc gtc aca gga acc ccc acc gtc gtt ccc ctc agt cgg tct cgc gca 720Pro Val Thr Gly Thr Pro Thr Val Val Pro Leu Ser Arg Ser Arg Ala 225230235240 gga gct taagtagcta cccctccaac gga 749Gly Ala<210>378<211>242<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>378Leu Asn Val Thr Ile Pro Asp Asn Thr Phe Thr Ala Ile Ile Gly Pro 151015 Asn Gly Cys Gly Lys Ser Thr Leu Leu Arg Gly Phe Ser Arg Val Leu

20 25 30Asn Pro Gln His Gly Lys Val Leu Leu Asp Gly Arg Gln Leu Asp Ser

35 40 45Phe Lys Pro Lys Glu Ile Ala Arg Glu Leu Gly Leu Leu Pro Gln Thr

50 55 60Ser Ile Ala Pro Glu Gly Ile Arg Val Tyr Asp Leu Ile Ala Arg Gly 65 70 75 80Arg Ala Pro Tyr Gln Ser Leu Ile Gln Gln Trp Arg Thr Ser Asp Glu

85 90 95Asp Ala Val Ala Gln Ala Leu Ala Ser Thr Asn Leu Thr Glu Leu Ala

100 105 110Ala Arg Leu Val Asp Glu Leu Ser Gly Gly Gln Arg Gln Arg Val Trp

115 120 125Val Ala Met Leu Leu Ala Gln Gln Thr Pro Ile Met Leu Leu Asp Glu

130 135 140Pro Thr Thr Phe Leu Asp Ile Ala His Gln Tyr Glu Leu Leu Glu Leu145 150 155 160Leu Arg Ala Phe Asn Glu Ala Gly Lys Thr Val Val Thr Val Leu His

165 170 175Asp Leu Asn Gln Ala Ala Arg Tyr Ala Asp His Leu Ile Val Met Lys

180 185 190Asp Gly His Val His Ala Thr Gly Thr Pro Glu Glu Val Leu Thr Ala

195 200 205Glu Met Val Gln Gly Val Phe Gly Leu Pro Cys Ile Ile Ser Pro Asp

210215220 Pro Val Thr Gly Thr Pro Thr Val Val Pro Leu Ser Arg Ser Arg Ala 225230235240 Gly Ala<210>379<211>1149<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1126)<223>RXN00523<400>37 379tggtgactcg tccgagtgaa attgccgtgg gcatcatcat gccgatcatt ggtgcgccac 60tgtttatttg gattattcgt cgtcagaaag tcaaagagct atg agc cttagc cat 115

Met Ser Leu Ser His

1 5caa ctc aag cgc cag cgc gca tcg cgc aac tcc cgc agg tgg ctg att 163Gln Leu Lys Arg Gln Arg Ala Ser Arg Asn Ser Arg Arg Trp Leu Ile

10 15 20gtt gcg gca ttg ggc gtc gtc acg ctt ggt att ttt gct ttt tct ttg 211Val Ala Ala Leu Gly Val Val Thr Leu Gly Ile Phe Ala Phe Ser Leu

25 30 35atg tgg ggc gag gtg ttt tat ggc cct gct cag gtg ctg aaa gtg ttg 259Met Trp Gly Glu Val Phe Tyr Gly Pro Ala Gln Val Leu Lys Val Leu

40 45 50tct gga cag cag gtt ccc ggc gcg agt tat tcc gtt ggc gtg ttg cgt 307Ser Gly Gln Gln Val Pro Gly Ala Ser Tyr Ser Val Gly Val Leu Arg

55 60 65ttg ccg cgc gcg gtg atg ggt ttg act gcg ggt ttg gcg ttt ggc gcg 355Leu Pro Arg Ala Val Met Gly Leu Thr Ala Gly Leu Ala Phe Gly Ala 70 75 80 85gcg ggc gtg att ttt cag acg gtg ttg cgt aat cag ttg gcg tcg ccg 403Ala Gly Val Ile Phe Gln Thr Val Leu Arg Asn Gln Leu Ala Ser Pro

90 95 100gat att atc ggc att tct tct ggc gcg tcg gcg gcg ggc gta att tgc 451Asp Ile Ile Gly Ile Ser Ser Gly Ala Ser Ala Ala Gly Val Ile Cys

105 110 115att gtg ttt ttc ggg atg tcg cag tct gca gtg tcg gcg att tct ttg 499Ile Val Phe Phe Gly Met Ser Gln Ser Ala Val Ser Ala Ile Ser Leu

120 125 130tgt gcg tcc ttg gct gtg gcg ttg ttg att tat ctg gtg gcg tat cgc 547Cys Ala Ser Leu Ala Val Ala Leu Leu Ile Tyr Leu Val Ala Tyr Arg

135 140 145ggt ggt ttt tcg gcc acg cgt ctg att ctt acc ggc att ggt att gct 595Gly Gly Phe Ser Ala Thr Arg Leu Ile Leu Thr Gly Ile Gly Ile Ala150 155 160 165gcg atg ctg aat tca tta gtg tcg tat tcg ctg tcc aag gct gat tct 643Ala Met Leu Asn Ser Leu Val Ser Tyr Ser Leu Ser Lys Ala Asp Ser

170 175 180tgg gat ctg ccg acc gcg acg cgc tgg ctt acc ggc tcg ctc aat ggt 691Trp Asp Leu Pro Thr Ala Thr Arg Trp Leu Thr Gly Ser Leu Asn Gly

185 190 195gcg acg tgg gat cgt gcg atg ccg ctg att gtc acc act gtg gta ctc 739Ala Thr Trp Asp Arg Ala Met Pro Leu Ile Val Thr Thr Val Val Leu

200 205 210att ccg ctg ctg gtg gct aat gcg cgc aat gtg gat ctt atg cgt ttg 787Ile Pro Leu Leu Val Ala Asn Ala Arg Asn Val Asp Leu Met Arg Leu

215 220 225ggc aat gat tcc gcg gtg ggt ttg ggc gtt gct act aat cgc acg cgc 835Gly Asn Asp Ser Ala Val Gly Leu Gly Val Ala Thr Asn Arg Thr Arg230 235 240 245gtc att gcg att att gcc gct gtt gcg ctc atc gcc gtt gct acc gct 883Val Ile Ala Ile Ile Ala Ala Val Ala Leu Ile Ala Val Ala Thr Ala

250 255 260gca tgc ggc ccg atc gca ttc gtg gcg ttt gtg tct ggc ccc att gcc 931Ala Cys Gly Pro Ile Ala Phe Val Ala Phe Val Ser Gly Pro Ile Ala

265 270 275gcg cgc att tta ggc tcc ggc gga tcg ctc atc atc ccc tcc gca ctc 979Ala Arg Ile Leu Gly Ser Gly Gly Ser Leu Ile Ile Pro Ser Ala Leu

280 285 290atc ggc ggg ttg atc gtgctc atc gcc gac cta att ggc caa tac ttc 1027Ile Gly Gly Leu Ile Val Leu Ile Ala Asp Leu Ile Gly Gln Tyr Phe

295 300 305ctc ggc acc cgc tac ccc gtc gga gtt gtc acc ggc gca ttc ggc gcc 1075Leu Gly Thr Arg Tyr Pro Val Gly Val Val Thr Gly Ala Phe Gly Ala310 315 320 325cca ttc ctt atc tat tta ctc att cgt tcc aac cgc gcg gga gta acc 1123Pro Phe Leu Ile Tyr Leu Leu Ile Arg Ser Asn Arg Ala Gly Val Thr

330335340 ctg tgaccaccaa ccatcaacta tcc 1149Leu<210>380<211>342<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>380Met Ser Leu Ser His Gln Leu Lys Arg Gln Arg Ala Ser Arg Asn Ser 151015 Arg Arg Trp Leu Ile Val Ala Ala Leu Gly Val Val Thr Leu Gly Ile

20 25 30Phe Ala Phe Ser Leu Met Trp Gly Glu Val Phe Tyr Gly Pro Ala Gln

35 40 45Val Leu Lys Val Leu Ser Gly Gln Gln Val Pro Gly Ala Ser Tyr Ser

50 55 60Val Gly Val Leu Arg Leu Pro Arg Ala Val Met Gly Leu Thr Ala Gly 65 70 75 80Leu Ala Phe Gly Ala Ala Gly Val Ile Phe Gln Thr Val Leu Arg Asn

85 90 95Gln Leu Ala Ser Pro Asp Ile Ile Gly Ile Ser Ser Gly Ala Ser Ala

100 105 110Ala Gly Val Ile Cys Ile Val Phe Phe Gly Met Ser Gln Ser Ala Val

115 120 125Ser Ala Ile Ser Leu Cys Ala Ser Leu Ala Val Ala Leu Leu Ile Tyr

130 135 140Leu Val Ala Tyr Arg Gly Gly Phe Ser Ala Thr Arg Leu Ile Leu Thr145150 155 160Gly Ile Gly Ile Ala Ala Met Leu Asn Ser Leu Val Ser Tyr Ser Leu

165 170 175Ser Lys Ala Asp Ser Trp Asp Leu Pro Thr Ala Thr Arg Trp Leu Thr

180 185 190Gly Ser Leu Asn Gly Ala Thr Trp Asp Arg Ala Met Pro Leu Ile Val

195 200 205Thr Thr Val Val Leu Ile Pro Leu Leu Val Ala Asn Ala Arg Asn Val

210 215 220Asp Leu Met Arg Leu Gly Asn Asp Ser Ala Val Gly Leu Gly Val Ala225 230 235 240Thr Asn Arg Thr Arg Val Ile Ala Ile Ile Ala Ala Val Ala Leu Ile

245 250 255Ala Val Ala Thr Ala Ala Cys Gly Pro Ile Ala Phe Val Ala Phe Val

260 265 270Ser Gly Pro Ile Ala Ala Arg Ile Leu Gly Ser Gly Gly Ser Leu Ile

275 280 285Ile Pro Ser Ala Leu Ile Gly Gly Leu Ile Val Leu Ile Ala Asp Leu

290 295 300Ile Gly Gln Tyr Phe Leu Gly Thr Arg Tyr Pro Val Gly Val Val Thr305 3l0 315 320Gly Ala Phe Gly Ala Pro Phe Leu Ile Tyr Leu Leu Ile Arg Ser Asn

325 330 335Arg Ala Gly Val Thr Leu

340<210>381<211>621<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (598)<223>RXN01142<400>381ctccccatcc accggcacag tcagcgcagg caacgaagaa attaaaggac caggacctga 60ccgaggcatg gttttccaag accacgccct cctgccctga ttgacc gca cgc ggc 115

Leu Thr Ala Arg Gly

1 5aac atc gac ttc ggg ctc cgc tcc gcg cgc ccc tcc ttg agc aaa acc 163Asn Ile Asp Phe Gly Leu Arg Ser Ala Arg Pro Ser Leu Ser Lys Thr

10 15 20gaa cgc gcc gac atc acc cgc acc cac ctc gaa caa gta ggc ctc acc 211Glu Arg Ala Asp Ile Thr Arg Thr His Leu Glu Gln Val Gly Leu Thr

25 30 35gac gcc gcc gaa cgg cgc ccc gcc cgc ctc tcc ggc ggc atg caa cag 259Asp Ala Ala Glu Arg Arg Pro Ala Arg Leu Ser Gly Gly Met Gln Gln

40 45 50cga gtc ggc atc gca cgc gcc ttc gcc atc gac cca cca atc atg ctt 307Arg Val Gly Ile Ala Arg Ala Phe Ala Ile Asp Pro Pro Ile Met Leu

55 60 65ctc gac gaa ccc ttc ggc gcc ctc gac gcc ctc acc cgc cgc gaa ctc 355Leu Asp Glu Pro Phe Gly Ala Leu Asp Ala Leu Thr Arg Arg Glu Leu 70 75 80 85cag ctc caa cta ctc aac att tgg gaa gcc tcc cgc cgc acc gtc gtc 403Gln Leu Gln Leu Leu Asn Ile Trp Glu Ala Ser Arg Arg Thr Val Val

90 95 100atg gtc acc cac gac gtc gac gag gcc atc ctg ctc tcc gac cga gtt 451Met Val Thr His Asp Val Asp Glu Ala Ile Leu Leu Ser Asp Arg Val

105 110 115ctc gtg atg tcc aag agc ccc gaa gcc acc atc atc acc gat att cca 499Leu Val Met Ser Lys Ser Pro Glu Ala Thr Ile Ile Thr Asp Ile Pro

120 125 130gtg aat ctt ccc cgc ccc aga cac gag ctg agt gaa gac gct tct gtt 547Val Asn Leu ProArg Pro Arg His Glu Leu Ser Glu Asp Ala Ser Val

135140145 gaa gcc gag acc aca gcc ctg cgt aag cgg atg ctg cat ctg ctg gag 595Glu Ala Glu Thr Thr Ala Leu Arg Lys Arg Met Leu His Leu Leu Glu 150155160165 cac tagtttctaa cacgtctttt aaa 621His<210>382<211>166<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>382Leu Thr Ala Arg Gly Asn Ile Asp Phe Gly Leu Arg Ser Ala Arg Pro 151015 Ser Leu Ser Lys Thr Glu Arg Ala Asp Ile Thr Arg Thr His Leu Glu

20 25 30Gln Val Gly Leu Thr Asp Ala Ala Glu Arg Arg Pro Ala Arg Leu Ser

35 40 45Gly Gly Met Gln Gln Arg Val Gly Ile Ala Arg Ala Phe Ala Ile Asp

50 55 60Pro Pro Ile Met Leu Leu Asp Glu Pro Phe Gly Ala Leu Asp Ala Leu 65 70 75 80Thr Arg Arg Glu Leu Gln Leu Gln Leu Leu Asn Ile Trp Glu Ala Ser

85 90 95Arg Arg Thr Val Val Met Val Thr His Asp Val Asp Glu Ala Ile Leu

100 105 110Leu Ser Asp Arg Val Leu Val Met Ser Lys Ser Pro Glu Ala Thr Ile

115 120 125Ile Thr Asp Ile Pro Val Asn Leu Pro Arg Pro Arg His Glu Leu Ser

130 135 140Glu Asp Ala Ser Val Glu Ala Glu Thr Thr Ala Leu Arg Lys Arg Met145 150 155 160Leu His Leu Leu Glu His

165<210>383<211>948<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (925)<223>RXN01141<400>383aaagaacact cggtatggca cctgatttaa ggatgctgca atcgtgacac atatcctctt 60cgacagcagg cgttttctgc aactgggcgc ttttgcgtcc ttg agc acc gca ttg 115

Leu Ser Thr Ala Leu

1 5gcc gga gcg gcc cgc tac gtg acg tcg aca agc aat aat gaa cct gcg 163Ala Gly Ala Ala Arg Tyr Val Thr Ser Thr Ser Asn Asn Glu Pro Ala

10 15 20gat aac act ccc ctg acc att ggc tac gtg cct att gcg ggc tcg gcg 211Asp Asn Thr Pro Leu Thr Ile Gly Tyr Val Pro Ile Ala Gly Ser Ala

25 30 35ccg att gct atc gca gat gcg cta ggg ctg ttt aag aaa cac ggc gtg 259Pro Ile Ala Ile Ala Asp Ala Leu Gly Leu Phe Lys Lys His Gly Val

40 45 50aat gtc acg ttg aag aag tac tca ggc tgg tcc gac ctg tgg acc gcc 307Asn Val Thr Leu Lys Lys Tyr Ser Gly Trp Ser Asp Leu Trp Thr Ala

55 60 65tat gca aca gag cag ctt gat gtt gcg cac atg ctg tcg ccg atg act 355Tyr Ala Thr Glu Gln Leu Asp Val Ala His Met Leu Ser Pro Met Thr70 75 80 85gtg gcg att aat gct gga gtg acc aac gcg tcg cgc ccg acg gag ctg 403Val Ala Ile Asn Ala Gly Val Thr Asn Ala Ser Arg Pro Thr Glu Leu

90 95 100tcg ttt acc cag aac acc aat ggg caa gca att acc ttg gcg tca aag 451Ser Phe Thr Gln Asn Thr Asn Gly Gln Ala Ile Thr Leu Ala Ser Lys

105 110 115cac tat ggt tcc gtc aat tca gcg gcg gat ctt aaa ggc atg gtg ctg 499His Tyr Gly Ser Val Asn Ser Ala Ala Asp Leu Lys Gly Met Val Leu

120 125130gga att cct ttt gaa tat tca gtc cat gcg ctg ctc ctg cgc gat tat 547Gly Ile Pro Phe Glu Tyr Ser Val His Ala Leu Leu Leu Arg Asp Tyr

135 140 145ctc gtc tca aac gca gtt gat ccc atc gcc gat ctt gag ctt cgc ctg 595Leu Val Ser Asn Ala Val Asp Pro Ile Ala Asp Leu Glu Leu Arg Leu150 155 160 165ctc cga cct gcc gat atg gtc gca caa ttg aca gtt gag ggc atc gat 643Leu Arg Pro Ala Asp Met Val Ala Gln Leu Thr Val Glu Gly Ile Asp

170 175 180gga ttc att ggg cct ggg ccg ttt aat gaa cgc gcc atc agc aat ggc 691Gly Phe Ile Gly Pro Gly Pro Phe Asn Glu Arg Ala Ile Ser Asn Gly

185 190 195tcc ggc cgg att tgg ctg ctg acc aaa caa ctg tgg gac aaa cat cca 739Ser Gly Arg Ile Trp Leu Leu Thr Lys Gln Leu Trp Asp Lys His Pro

200 205 210tgc tgc gcc gtg gcg atg gcc aaa gag tgg aaa gct gaa cac ccc acg 787Cys Cys Ala Val Ala Met Ala Lys Glu Trp Lys Ala Glu His Pro Thr

215 220 225gcg gct cag ggt gtg ctt aat gcg ctg gag gaa gcc tcc gca att ttg 835Ala Ala Gln Gly Val Leu Asn Ala Leu Glu Glu Ala Ser Ala Ile Leu230 235 240 245agc aat ccg gca caa ttt gat tcc tcg gca cgc acg ctg tcg cag gaa 883Ser Asn Pro Ala Gln Phe Asp Ser Ser Ala Arg Thr Leu Ser Gln Glu

250 255 260aaa tac ctc aac cag cct gcc acg ttg ctg gat gga ccg tcg 925Lys Tyr Leu Asn Gln Pro Ala Thr Leu Leu Asp Gly Pro Ser

265270275 taatcatcgg catcaccggc tta 948<210>384<211>275<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>384Leu Ser Thr Ala Leu Ala Gly Ala Ala Arg Tyr Val Thr Ser Thr Ser 151015 Asn Asn Glu Pro Ala Asp Asn Thr Pro Leu Thr Ile Gly Tyr Val Pro

20 25 30Ile Ala Gly Ser Ala Pro Ile Ala Ile Ala Asp Ala Leu Gly Leu Phe

35 40 45Lys Lys His Gly Val Asn Val Thr Leu Lys Lys Tyr Ser Gly Trp Ser

50 55 60Asp Leu Trp Thr Ala Tyr Ala Thr Glu Gln Leu Asp Val Ala His Met 65 70 75 80Leu Ser Pro Met Thr Val Ala Ile Asn Ala Gly Val Thr Asn Ala Ser

85 90 95Arg Pro Thr Glu Leu Ser Phe Thr Gln Asn Thr Asn Gly Gln Ala Ile

100 105 110Thr Leu Ala Ser Lys His Tyr Gly Ser Val Asn Ser Ala Ala Asp Leu

115 120 125Lys Gly Met Val Leu Gly Ile Pro Phe Glu Tyr Ser Val His Ala Leu

130 135 140Leu Leu Arg Asp Tyr Leu Val Ser Asn Ala Val Asp Pro Ile Ala Asp145 150 155 160Leu Glu Leu Arg Leu Leu Arg Pro Ala Asp Met Val Ala Gln Leu Thr

165 170 175Val Glu Gly Ile Asp Gly Phe Ile Gly Pro Gly Pro Phe Asn Glu Arg

180 185 190Ala Ile Ser Asn Gly Ser Gly Arg Ile Trp Leu Leu Thr Lys Gln Leu

195 200 205Trp Asp Lys His Pro Cys Cys Ala Val Ala Met Ala Lys Glu Trp Lys

210 215 220Ala Glu His Pro Thr Ala Ala Gln Gly Val Leu Asn Ala Leu Glu Glu225 230235 240Ala Ser Ala Ile Leu Ser Asn Pro Ala Gln Phe Asp Ser Ser Ala Arg

245 250 255Thr Leu Ser Gln Glu Lys Tyr Leu Asn Gln Pro Ala Thr Leu Leu Asp

260 265 270Gly Pro Ser

275<210>385<211>927<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (904)<223>RXN01002<400>385gactgctgat accgcacagg atgaaatcac tcgttacggc gagatcctga agaagttctc 60caactaattt ccctgtttcc aatactcaag gtgtgcgcat atg aat tct gat gct 115

Met Asn Ser Asp Ala

1 5tcg gct acc acc aac tcc tgg gct atc aac ttc gac cat gtg tcg gtg 163Ser Ala Thr Thr Asn Ser Trp Ala Ile Asn Phe Asp His Val Ser Val

10 15 20acg tat ccc aat ggg acg aaa gcc ctc gat gat gtt tcc ctc acc atc 211Thr Tyr Pro Asn Gly Thr Lys Ala Leu Asp Asp Val Ser Leu Thr Ile

25 30 35aat ccc ggt gag atg gtt gcc atc gtg ggt ctg tca gga tcg ggt aaa 259Asn Pro Gly Glu Met Val Ala Ile Val Gly Leu Ser Gly Ser Gly Lys

40 45 50tcc acg ctg att cgc acg atc aac ggt ctt gtc cgc gct acg gaa ggc 307Ser Thr Leu Ile Arg Thr Ile Asn Gly Leu Val Arg Ala Thr Glu Gly

55 60 65acc gtg acg gtg ggg ccg cat cag atc aac acc ttg aag ggg aaa gca 355Thr Val Thr Val Gly Pro His Gln Ile Asn Thr Leu Lys Gly Lys Ala 70 75 80 85ctg cgt gat gcc cgt ggg cag atc ggc atg att ttc cagggg ttc aac 403Leu Arg Asp Ala Arg Gly Gln Ile Gly Met Ile Phe Gln Gly Phe Asn

90 95 100ctg tcg gaa cgc agc agt gtg ttc cag aat gtt ttg gtg ggc cgc ttc 451Leu Ser Glu Arg Ser Ser Val Phe Gln Asn Val Leu Val Gly Arg Phe

105 110 115gcg cac aca gcg tgg tgg cgt aac ctc ctc ggg ttt ccc acg gag cac 499Ala His Thr Ala Trp Trp Arg Asn Leu Leu Gly Phe Pro Thr Glu His

120 125 130gac aag cag att gct ttt cac gcg ttg gag tcc gtg ggc att ttg cac 547Asp Lys Gln Ile Ala Phe His Ala Leu Glu Ser Val Gly Ile Leu His

135 140 145aaa gtg tgg acc cga gct ggt gct ttg tcg ggt gga cag aaa cag cgc 595Lys Val Trp Thr Arg Ala Gly Ala Leu Ser Gly Gly Gln Lys Gln Arg150 155 160 165gtt gct att gcg cgc gcc tta tcg caa gat ccg tct gtc atg ctg gca 643Val Ala Ile Ala Arg Ala Leu Ser Gln Asp Pro Ser Val Met Leu Ala

170 175 180gat gag cct gtg gca agc ctt gat ccg cca acc gcg cat tcc gtg atg 691Asp Glu Pro Val Ala Ser Leu Asp Pro Pro Thr Ala His Ser Val Met

185 190 195cgc gat cta gaa aac atc aac aac gtg gaa ggc ctc acc gtg ttg gtg 739Arg Asp Leu Glu Asn Ile Asn Asn Val Glu Gly Leu Thr Val Leu Val

200 205 210aac ttg cac ttg att gat ttg gct cgt caa tac acc aca agg ctt gtg 787Asn Leu His Leu Ile Asp Leu Ala Arg Gln Tyr Thr Thr Arg Leu Val

215 220 225ggt ttg cgt gcc ggc aag ctg gtc tat gac ggt cct atc tct gag gcc 835Gly Leu Arg Ala Gly Lys Leu Val Tyr Asp Gly Pro Ile Ser Glu Ala230235 240 245acc gat aaa gac ttt gaa gct atc tat ggt cgc ccc atc cag gct aaa 883Thr Asp Lys Asp Phe Glu Ala Ile Tyr Gly Arg Pro Ile Gln Ala Lys

250 255 260gac ctg cta ggt gat cgc gca tgaccacgcc ttcttctaca ctt 927Asp Leu Leu Gly Asp Arg Ala

265<210>386<211>268<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>386Met Asn Ser Asp Ala Ser Ala Thr Thr Asn Ser Trp Ala Ile Asn Phe 151015 Asp His Val Ser Val Thr Tyr Pro Asn Gly Thr Lys Ala Leu Asp Asp

20 25 30Val Ser Leu Thr Ile Asn Pro Gly Glu Met Val Ala Ile Val Gly Leu

35 40 45Ser Gly Ser Gly Lys Ser Thr Leu Ile Arg Thr Ile Asn Gly Leu Val

50 55 60Arg Ala Thr Glu Gly Thr Val Thr Val Gly Pro His Gln Ile Asn Thr 65 70 75 80Leu Lys Gly Lys Ala Leu Arg Asp Ala Arg Gly Gln Ile Gly Met Ile

85 90 95Phe Gln Gly Phe Asn Leu Ser Glu Arg Ser Ser Val Phe Gln Asn Val

100 105 110Leu Val Gly Arg Phe Ala His Thr Ala Trp Trp Arg Asn Leu Leu Gly

115 120 125Phe Pro Thr Glu His Asp Lys Gln Ile Ala Phe His Ala Leu Glu Ser

130 135 140Val Gly Ile Leu His Lys Val Trp Thr Arg Ala Gly Ala Leu Ser Gly145 150 155 160Gly Gln Lys Gln Arg Val Ala Ile Ala Arg Ala Leu Ser Gln Asp Pro

165170 175Ser Val Met Leu Ala Asp Glu Pro Val Ala Ser Leu Asp Pro Pro Thr

180 185 190Ala His Ser Val Met Arg Asp Leu Glu Asn Ile Asn Asn Val Glu Gly

195 200 205Leu Thr Val Leu Val Asn Leu His Leu Ile Asp Leu Ala Arg Gln Tyr

210 215 220Thr Thr Arg Leu Val Gly Leu Arg Ala Gly Lys Leu Val Tyr Asp Gly225 230 235 240Pro Ile Ser Glu Ala Thr Asp Lys Asp Phe Glu Ala Ile Tyr Gly Arg

245 250 255Pro Ile Gln Ala Lys Asp Leu Leu Gly Asp Arg Ala

260265<210>387<211>969<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<946)<223>RXN01000<400>387ctttctatgc ctacgcggat gtttccgtga tcattctgga aatcctcatc gtggtgattg 60tcattgaagt aatctccaac gcacttcgaa agaggctggt atg agc acc tta acc 115

Met Ser Thr Leu Thr

1 5tct cac cgc aca gta ccg gcc ccc agc tct ccc ccg gcg cgc ccc aac 163Ser His Arg Thr Val Pro Ala Pro Ser Ser Pro Pro Ala Arg Pro Asn

10 15 20aaa ctg gcg cgc aat atc gtt gca att gtc gct gcg ctg att gtc ctt 211Lys Leu Ala Arg Asn Ile Val Ala Ile Val Ala Ala Leu Ile Val Leu

25 30 35ata gct acc ggc acg ctc aag atc gag tgg aat gag ctt ccg cag atg 259Ile Ala Thr Gly Thr Leu Lys Ile Glu Trp Asn Glu Leu Pro Gln Met

40 4550ccc gcg cag gtg tgg cat tac tta gag ctg atg ttt agc gat ccc gat 307Pro Ala Gln Val Trp His Tyr Leu Glu Leu Met Phe Ser Asp Pro Asp

55 60 65tgg tcg aag ttt ggc cgc gcc gtc cag gaa atg tgg cgt tcc atc gcc 355Trp Ser Lys Phe Gly Arg Ala Val Gln Glu Met Trp Arg Ser Ile Ala 70 75 80 85atg gcg tgg ttg ggt gcc att tta tgc gtg gtg gtc tct gtc cct ctg 403Met Ala Trp Leu Gly Ala Ile Leu Cys Val Val Val Ser Val Pro Leu

90 95 100gga atg ttg gct gcc cgc ggg gtg gga cct tat tgg ctg cgt acc gtt 451Gly Met Leu Ala Ala Arg Gly Val Gly Pro Tyr Trp Leu Arg Thr Val

105 110 115tta cgg ttc gtg ttc gcg gtg att cgt gcg ttc ccc gaa gtg gtt atc 499Leu Arg Phe Val Phe Ala Val Ile Arg Ala Phe Pro Glu Val Val Ile

120 125 130gca att att ttg cta act gtc acc ggc cta act cct ttt act ggt gcg 547Ala Ile Ile Leu Leu Thr Val Thr Gly Leu Thr Pro Phe Thr Gly Ala

135 140 145ctc gca ttg ggt atc tcc ggt att gga caa cag gca aag tgg acc tat 595Leu Ala Leu Gly Ile Ser Gly Ile Gly Gln Gln Ala Lys Trp Thr Tyr150 155 160 165gaa gcc att gag tcc act ccc acc ggc ccg tca gag gca gtg cgt gca 643Glu Ala Ile Glu Ser Thr Pro Thr Gly Pro Ser Glu Ala Val Arg Ala

170 175 180gcg ggt gga act acg ccg gag gtt ctg cgg tgg gcg ttg tgg cca cag 691Ala Gly Gly Thr Thr Pro Glu Val Leu Arg Trp Ala Leu Trp Pro Gln

185 190 195gtt gcg cca tcc att gca tct ttt gcc ctg tac cgc ttt gag atc aac 739Val Ala Pro Ser Ile Ala Ser Phe Ala Leu Tyr Arg Phe Glu Ile Asn

200 205 210atc cgt acc tct gcg gta ttg ggc atc gtt ggt gca ggt ggt atc ggt 787Ile Arg Thr Ser Ala Val Leu Gly Ile Val Gly Ala Gly Gly Ile Gly

215 220 225agt atg ctt gcc aat tac acc aac tac agg cag tgg gac acc gtg ggc 835Ser Met Leu Ala Asn Tyr Thr Asn Tyr Arg Gln Trp Asp Thr Val Gly230 235 240 245atg ctg ctc atc gtc gtg gtt gtc gca acg atg atc gtc gat ctc atc 883Met Leu Leu Ile Val Val Val Val Ala Thr Met Ile Val Asp Leu Ile

250 255 260tcc ggc acc atc cgc cgc cgc atc atg aag ggg gct agt gac cgt gtc 931Ser Gly Thr Ile Arg Arg Arg Ile Met Lys Gly Ala Ser Asp Arg Val

265 270 275gtg gca cca agc aac tgacgctcca ccaagcatcc gca 969Val Ala Pro Ser Asn

280<210>388<211>282<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>388Met Ser Thr Leu Thr Ser His Arg Thr Val Pro Ala Pro Ser Ser Pro 151015 Pro Ala Arg Pro Asn Lys Leu Ala Arg Asn Ile Val Ala Ile Val Ala

20 25 30Ala Leu Ile Val Leu Ile Ala Thr Gly Thr Leu Lys Ile Glu Trp Asn

35 40 45Glu Leu Pro Gln Met Pro Ala Gln Val Trp His Tyr Leu Glu Leu Met

50 55 60Phe Ser Asp Pro Asp Trp Ser Lys Phe Gly Arg Ala Val Gln Glu Met 65 70 75 80Trp Arg Ser Ile Ala Met Ala Trp Leu Gly Ala Ile Leu Cys Val Val

85 90 95Val Ser Val Pro Leu Gly Met Leu Ala Ala Arg Gly Val Gly Pro Tyr

100 105 110Trp Leu Arg Thr Val Leu Arg Phe Val Phe Ala Val Ile Arg Ala Phe

115 120 125Pro Glu Val Val Ile Ala Ile Ile Leu Leu Thr Val Thr Gly Leu Thr

130 135 140Pro Phe Thr Gly Ala Leu Ala Leu Gly Ile Ser Gly Ile Gly Gln Gln145 150 155 160Ala Lys Trp Thr Tyr Glu Ala Ile Glu Ser Thr Pro Thr Gly Pro Ser

165 170 175Glu Ala Val Arg Ala Ala Gly Gly Thr Thr Pro Glu Val Leu Arg Trp

180 185 190Ala Leu Trp Pro Gln Val Ala Pro Ser Ile Ala Ser Phe Ala Leu Tyr

195 200 205Arg Phe Glu Ile Asn Ile Arg Thr Ser Ala Val Leu Gly Ile Val Gly

210 215 220Ala Gly Gly Ile Gly Ser Met Leu Ala Asn Tyr Thr Asn Tyr Arg Gln225 230 235 240Trp Asp Thr Val Gly Met Leu Leu Ile Val Val Val Val Ala Thr Met

245 250 255Ile Val Asp Leu Ile Ser Gly Thr Ile Arg Arg Arg Ile Met Lys Gly

260 265 270Ala Ser Asp Arg Val Val Ala Pro Ser Asn

275280<210>389<211>1173<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).)

Met Phe Lys Leu Ser

1 5aag cca tcc aag tcc atg cgt gtt gct gtt tct acgctt gcg atc tct 163Lys Pro Ser Lys Ser Met Arg Val Ala Val Ser Thr Leu Ala Ile Ser

10 15 20acc ctt gct cta gtt ggt tgt tcc tct tcc gat gag tct tct tcc tca 211Thr Leu Ala Leu Val Gly Cys Ser Ser Ser Asp Glu Ser Ser Ser Ser

25 30 35tca tct gcg tct tct tct tcg gat gct gca agc cag tgg cct gag tcc 259Ser Ser Ala Ser Ser Ser Ser Asp Ala Ala Ser Gln Trp Pro Glu Ser

40 45 50att act ttg tct ctt gtt cct tct act gag ggt gag gat ttg gct gaa 307Ile Thr Leu Ser Leu Val Pro Ser Thr Glu Gly Glu Asp Leu Ala Glu

55 60 65gcg ttg gct cct ttg act gat tac ctg tct gag aac ctt ggt att gag 355Ala Leu Ala Pro Leu Thr Asp Tyr Leu Ser Glu Asn Leu Gly Ile Glu 70 75 80 85gtc aat ggt gtg gtg gcg tct gat tac gct gca acc gtt gag gct ttg 403Val Asn Gly Val Val Ala Ser Asp Tyr Ala Ala Thr Val Glu Ala Leu

90 95 100ggt gct gat cag gct cag gtg atc atc act gat gcg ggt tcc ctg tat 451Gly Ala Asp Gln Ala Gln Val Ile Ile Thr Asp Ala Gly Ser Leu Tyr

105 110 115aac gcg att gag cag tac gat gcg cag ctg att ctg cgt gat gtg cgt 499Asn Ala Ile Glu Gln Tyr Asp Ala Gln Leu Ile Leu Arg Asp Val Arg

120 125 130ttc ggt gcc acc tcg tac tct gct gtg gcg tac acc aac aat cct gat 547Phe Gly Ala Thr Ser Tyr Ser Ala Val Ala Tyr Thr Asn Asn Pro Asp

135 140 145aag tac tgc gac gat gcc cca gtg gct gcg tct tat gct gcg tcc gat 595Lys Tyr Cys Asp Asp Ala Pro Val Ala Ala Ser Tyr Ala Ala Ser Asp150155 160 165gta gac atg ctt tac tgc aac ggt att gaa act gag ggc cag gct gct 643Val Asp Met Leu Tyr Cys Asn Gly Ile Glu Thr Glu Gly Gln Ala Ala

170 175 180acc ggt gag ggc cca gca gct ctt gat gcg ctg gaa aag atc gag tcc 691Thr Gly Glu Gly Pro Ala Ala Leu Asp Ala Leu Glu Lys Ile Glu Ser

185 190 195ggt gac aag gta gcg ctg cag gct gca acc tct cct gcg ggt tac cag 739Gly Asp Lys Val Ala Leu Gln Ala Ala Thr Ser Pro Ala Gly Tyr Gln

200 205 210tac cct atc gtc gct atg cag gat ctg ggc atg gat acc gat tcc gct 787Tyr Pro Ile Val Ala Met Gln Asp Leu Gly Met Asp Thr Asp Ser Ala

215 220 225ttt gtt cag gtt cca gta gag ggc aac aac aac gct gtg ctg tct gtc 835Phe Val Gln Val Pro Val Glu Gly Asn Asn Asn Ala Val Leu Ser Val230 235 240 245ctg aac ggt gac gcg gaa gtg tcc ttc ggt ttc tgg gat gcg cgt tcc 883Leu Asn Gly Asp Ala Glu Val Ser Phe Gly Phe Trp Asp Ala Arg Ser

250 255 260acc gtg ctg tct gag gct cct aac gca gct gag gat gtc gta gcg ttt 931Thr Val Leu Ser Glu Ala Pro Asn Ala Ala Glu Asp Val Val Ala Phe

265 270 275gcc tac acc gag atg atc cct aac ggt ggc gtc gca gcg tcc aag tcc 979Ala Tyr Thr Glu Met Ile Pro Asn Gly Gly Val Ala Ala Ser Lys Ser

280 285 290ctt cca tcc gac ctg gtg gaa aag ctc acc gag ttg atg gat gat tac 1027Leu Pro Ser Asp Leu Val Glu Lys Leu Thr Glu Leu Met Asp Asp Tyr

295 300 305gca gat tcc tcc gag gaa gcc aag gat gtc atg ttc gac atg gttggt 1075Ala Asp Ser Ser Glu Glu Ala Lys Asp Val Met Phe Asp Met Val Gly310 315 320 325cta tct gac tgg act gct gat acc gca cag gat gaa atc act cgt tac 1123Leu Ser Asp Trp Thr Ala Asp Thr Ala Gln Asp Glu Ile Thr Arg Tyr

330 335 340ggc gag atc ctg aag aag ttc tcc aac taatttccct gtttccaata 1170Gly Glu Ile Leu Lys Lys Phe Ser Asn

345350 ctc1173<210>390<211>350<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>390Met Phe Lys Leu Ser Lys Pro Ser Lys Ser Met Arg Val Ala Val Ser 151015 Thr Leu Ala Ile Ser Thr Leu Ala Leu Val Gly Gys Ser Ser Ser Asp

20 25 30Glu Ser Ser Ser Ser Ser Ser Ala Ser Ser Ser Ser Asp Ala Ala Ser

35 40 45Gln Trp Pro Glu Ser Ile Thr Leu Ser Leu Val Pro Ser Thr Glu Gly

50 55 60Glu Asp Leu Ala Glu Ala Leu Ala Pro Leu Thr Asp Tyr Leu Ser Glu 65 70 75 80Asn Leu Gly Ile Glu Val Asn Gly Val Val Ala Ser Asp Tyr Ala Ala

85 90 95Thr Val Glu Ala Leu Gly Ala Asp Gln Ala Gln Val Ile Ile Thr Asp

100 105 110Ala Gly Ser Leu Tyr Asn Ala Ile Glu Gln Tyr Asp Ala Gln Leu Ile

115 120 125Leu Arg Asp Val Arg Phe Gly Ala Thr Ser Tyr Ser Ala Val Ala Tyr

130 135 140Thr Asn Asn Pro Asp Lys Tyr Cys Asp Asp Ala Pro Val Ala Ala Ser145 150 155 160Tyr Ala Ala Ser Asp Val Asp Met Leu Tyr Cys Asn Gly Ile Glu Thr

165 170 175Glu Gly Gln Ala Ala Thr Gly Glu Gly Pro Ala Ala Leu Asp Ala Leu

180 185 190Glu Lys Ile Glu Ser Gly Asp Lys Val Ala Leu Gln Ala Ala Thr Ser

195 200 205Pro Ala Gly Tyr Gln Tyr Pro Ile Val Ala Met Gln Asp Leu Gly Met

210 215 220Asp Thr Asp Ser Ala Phe Val Gln Val Pro Val Glu Gly Asn Asn Asn225 230 235 240Ala Val Leu Ser Val Leu Asn Gly Asp Ala Glu Val Ser Phe Gly Phe

245 250 255Trp Asp Ala Arg Ser Thr Val Leu Ser Glu Ala Pro Asn Ala Ala Glu

260 265 270Asp Val Val Ala Phe Ala Tyr Thr Glu Met Ile Pro Asn Gly Gly Val

275 280 285Ala Ala Ser Lys Ser Leu Pro Ser Asp Leu Val Glu Lys Leu Thr Glu

290 295 300Leu Met Asp Asp Tyr Ala Asp Ser Ser Glu Glu Ala Lys Asp Val Met305 310 315 320Phe Asp Met Val Gly Leu Ser Asp Trp Thr Ala Asp Thr Ala Gln Asp

325 330 335Glu Ile Thr Arg Tyr Gly Glu Ile Leu Lys Lys Phe Ser Asn

340345350<210>391<211>903<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (880)<223>RXN03080<400>391cttgcaaaca ggcgtggtgg tggcgttcat tggctcacca attttccttt atttactgct 60cagcatgcgc aagcgacgcg gattggggct gtaaaaactc atg cct caa tta gtt 115

Met Pro Gln Leu Val

1 5gaa att cgt gat ctc aac gtt gaa ttc ccc tct cgc cat gca gtg aaa 163Glu Ile Arg Asp Leu Asn Val Glu Phe Pro Ser Arg His Ala Val Lys

10 15 20aac gtg tct ttt tct gca cct gct gga aaa gtc acc gca ctg att ggc 211Asn Val Ser Phe Ser Ala Pro Ala Gly Lys Val Thr Ala Leu Ile Gly

25 30 35cca aat ggt gct ggt aaa agt act gcc ctt tcg gcg att gca gga ttg 259Pro Asn Gly Ala Gly Lys Ser Thr Ala Leu Ser Ala Ile Ala Gly Leu

40 45 50gtt gaa tcc acc ggc gag gta atg gtt ggt ggg agt ggg gtt gcg tcg 307Val Glu Ser Thr Gly Glu Val Met Val Gly Gly Ser Gly Val Ala Ser

55 60 65aaa agc gct aaa gcc cga gcc cgc ctg ctc tca ctc gtg ccg caa aac 355Lys Ser Ala Lys Ala Arg Ala Arg Leu Leu Ser Leu Val Pro Gln Asn 70 75 80 85acc gag ttg cgc att ggt ttt agt gca cgc gac gtt gtc gcg atg ggc 403Thr Glu Leu Arg Ile Gly Phe Ser Ala Arg Asp Val Val Ala Met Gly

90 95 100cgc tac ccg cat cgt ggc cgc ttc gcc gtg gag acc gac gca gat cga 451Arg Tyr Pro His Arg Gly Arg Phe Ala Val Glu Thr Asp Ala Asp Arg

105 110 115cgc gcc acc gat gac gcc ctg cgc gcc atc aac gcg ctc gac atc gcc 499Arg Ala Thr Asp Asp Ala Leu Arg Ala Ile Asn Ala Leu Asp Ile Ala

120 125 130gag cag ccc gtc aac gaa tta tcg ggc ggc cag cag cag ctc atc cac 547Glu Gln Pro Val Asn Glu Leu Ser Gly Gly Gln Gln Gln Leu Ile His

135 140 145atc ggc cga gcg ctc gcc caa gac acc gcc gtc gtg ctt ctc gac gag 595Ile Gly Arg Ala Leu Ala Gln Asp Thr Ala Val Val Leu Leu Asp Glu150 155 160 165ccc gtc tcc gcc ctt gat cta cgg cac caa gtt gaa gtc ctt caa ctc 643Pro Val Ser Ala Leu Asp Leu Arg His Gln Val Glu Val Leu Gln Leu

170 175 180ctg cgc gcc cga gct aat tcc ggc acc acc gtg atc gtc gtc ctt cac 691Leu Arg Ala Arg Ala Asn Ser Gly Thr Thr Val Ile Val Val Leu His

185 190 195gat ctc aac cac gtt gcc cgt tgg tgc gac cat gca gtg ttg atg gcc 739Asp Leu Asn His Val Ala Arg Trp Cys Asp His Ala Val Leu Met Ala

200 205 210gac ggc gaa gtt gtc tcc caa ggt gac atc cgc gag gtg ctc gaa cct 787Asp Gly Glu Val Val Ser Gln Gly Asp Ile Arg Glu Val Leu Glu Pro

215 220 225gcc aca ctg tcc acc gtg tac gga ctg ccc att gcg gtg cgc gat gat 835Ala Thr Leu Ser Thr Val Tyr Gly Leu Pro Ile Ala Val Arg Asp Asp230 235 240 245ccc gaa acc agc tca ctt cgc gtg atc ccg cat cca aat ccc ttt 880Pro Glu Thr Ser Ser Leu Arg Val Ile Pro His Pro Asn Pro Phe

250255260 tgattgaaag tttgacttaa aaa 903<210>392<211>260<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>392Met Pro Gln Leu Val Glu Ile Arg Asp Leu Asn Val Glu Phe Pro Ser 151015 Arg His Ala Val Lys Asn Val Ser Phe Ser Ala Pro Ala Gly Lys Val

20 25 30Thr Ala Leu Ile Gly Pro Asn Gly Ala Gly Lys Ser Thr Ala Leu Ser

35 4045Ala Ile Ala Gly Leu Val Glu Ser Thr Gly Glu Val Met Val Gly Gly

50 55 60Ser Gly Val Ala Ser Lys Ser Ala Lys Ala Arg Ala Arg Leu Leu Ser 65 70 75 80Leu Val Pro Gln Asn Thr Glu Leu Arg Ile Gly Phe Ser Ala Arg Asp

85 90 95Val Val Ala Met Gly Arg Tyr Pro His Arg Gly Arg Phe Ala Val Glu

100 105 110Thr Asp Ala Asp Arg Arg Ala Thr Asp Asp Ala Leu Arg Ala Ile Asn

115 120 125Ala Leu Asp Ile Ala Glu Gln Pro Val Asn Glu Leu Ser Gly Gly Gln

130 135 140Gln Gln Leu Ile His Ile Gly Arg Ala Leu Ala Gln Asp Thr Ala Val145 150 155 160Val Leu Leu Asp Glu Pro Val Ser Ala Leu Asp Leu Arg His Gln Val

165 170 175Glu Val Leu Gln Leu Leu Arg Ala Arg Ala Asn Ser Gly Thr Thr Val

180 185 190Ile Val Val Leu His Asp Leu Asn His Val Ala Arg Trp Cys Asp His

195 200 205Ala Val Leu Met Ala Asp Gly Glu Val Val Ser Gln Gly Asp Ile Arg

210 215 220Glu Val Leu Glu Pro Ala Thr Leu Ser Thr Val Tyr Gly Leu Pro Ile225 230 235 240Ala Val Arg Asp Asp Pro Glu Thr Ser Ser Leu Arg Val Ile Pro His

245 250 255Pro Asn Pro Phe

260<210>393<211>582<212>DNA<213>Corynebacterium glutamicum (Corynebacteriumglutamicum)<220><221>CDS<222>(101). (559)<223>RXN03081<400>393acggactgcc cattgcggtg cgcgatgatc ccgaaaccag ctcacttcgc gtgatcccgc 60atccaaatcc cttttgattg aaagtttgac ttaaaaaccc atg aaa aaa tca ctc 115

Met Lys Lys Ser Leu

1 5atc gcc att gtt gcc agt gcg ctc gtg tta agc ggc tgc acc tct gat 163Ile Ala Ile Val Ala Ser Ala Leu Val Leu Ser Gly Cys Thr Ser Asp

10 15 20tct tct gac tct tcc ggc act tcc gga act gtg gaa acc act tcg att 211Ser Ser Asp Ser Ser Gly Thr Ser Gly Thr Val Glu Thr Thr Ser Ile

25 30 35aca acc agc gtt gcc gca gct gac ggc gca ttc cca cgc acc gtc aca 259Thr Thr Ser Val Ala Ala Ala Asp Gly Ala Phe Pro Arg Thr Val Thr

40 45 50ctc gac gat tcc tcc atc acc tta gaa tcc aaa cca gag cgc atc gcc 307Leu Asp Asp Ser Ser Ile Thr Leu Glu Ser Lys Pro Glu Arg Ile Ala

55 60 65gta ctc acc cca gag gca gca tcc ttg gtt ctc ccc atc aca ggc gcc 355Val Leu Thr Pro Glu Ala Ala Ser Leu Val Leu Pro Ile Thr Gly Ala 70 75 80 85gac cgc gtc gtg atg acc gcc gaa atg gac acc gct gac gaa gaa acc 403Asp Arg Val Val Met Thr Ala Glu Met Asp Thr Ala Asp Glu Glu Thr

90 95 100gca gct ctg gcc tcc caa gtg gaa tac caa gtc aaa aac ggt ggc agg 451Ala Ala Leu Ala Ser Gln Val Glu Tyr Gln Val Lys Asn Gly Gly Arg

105 110 115ctc gac ccc gaa caa gtt gtc gcc ggc gac cca gat ttg gtg atc gtc 499Leu Asp Pro Glu Gln Val Val Ala Gly Asp Pro Asp Leu Val Ile Val

120 125 130agt gcg cgt ttc gat acc gaa caa ggc acc atc gac att ttg gaa ggc 547Ser Ala Arg Phe Asp Thr Glu Gln Gly Thr Ile Asp Ile Leu Glu Gly

135140145 ctc aac gtc ccg tagttaactt cgattcagac gct 582Leu Asn Val Pro150<210>394<211>153<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>394Met Lys Lys Ser Leu Ile Ala Ile Val Ala Ser Ala Leu Val Leu Ser 151015 Gly Cys Thr Ser Asp Ser Ser Asp Ser Ser Gly Thr Ser Gly Thr Val

20 25 30Glu Thr Thr Ser Ile Thr Thr Ser Val Ala Ala Ala Asp Gly Ala Phe

35 40 45Pro Arg Thr Val Thr Leu Asp Asp Ser Ser Ile Thr Leu Glu Ser Lys

50 55 60Pro Glu Arg Ile Ala Val Leu Thr Pro Glu Ala Ala Ser Leu Val Leu 65 70 75 80Pro Ile Thr Gly Ala Asp Arg Val Val Met Thr Ala Glu Met Asp Thr

85 90 95Ala Asp Glu Glu Thr Ala Ala Leu Ala Ser Gln Val Glu Tyr Gln Val

100 105 110Lys Asn Gly Gly Arg Leu Asp Pro Glu Gln Val Val Ala Gly Asp Pro

115 120 125Asp Leu Val Ile Val Ser Ala Arg Phe Asp Thr Glu Gln Gly Thr Ile

130135140 Asp Ile Leu Glu Gly Leu Asn Val Pro 145150<210>395<211>444<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (421)<223>RXN03082<400>395cagaagcaat cgcagaaatc gatgcaaacc gcattcgaca ttcgacaagc ctgccacctc ccccactgtg ctcactttga tgcaacgcgg accacgccaa atg gtc atg cca gaa 115

Met Val Met Pro Glu

1 5tct gcc atg ctc acc ggc ctg atc cgc gaa gcc ggc ggc act cca gtg 163Ser Ala Met Leu Thr Gly Leu Ile Arg Glu Ala Gly Gly Thr Pro Val

10 15 20gta gat tct ctc ggc gcg gta ggc acc atc act gca gac cca gaa caa 211Val Asp Ser Leu Gly Ala Val Gly Thr Ile Thr Ala Asp Pro Glu Gln

25 30 35gtt gtt gcg atg gca cct gag atc atc atc att cag gac ttc caa ggt 259Val Val Ala Met Ala Pro Glu Ile Ile Ile Ile Gln Asp Phe Gln Gly

40 45 50aaa ggc cga gag aac ttc gct aat ttc ctc tcc aac cca gcg cta gcc 307Lys Gly Arg Glu Asn Phe Ala Asn Phe Leu Ser Asn Pro Ala Leu Ala

55 60 65aac gtt ccc gcc att gaa aac gac aag att ttc tac gcc gac act gtc 355Asn Val Pro Ala Ile Glu Asn Asp Lys Ile Phe Tyr Ala Asp Thr Val 70 75 80 85acc act gga gtt act gca ggt acc gat atc acc act ggt ctg cag caa 403Thr Thr Gly Val Thr Ala Gly Thr Asp Ile Thr Thr Gly Leu Gln Gln

90 95 100gtg gca gaa atg ctg agc tagttttgag atgttgaaac tag 444Val Ala Glu Met Leu Ser

105<210>396<211>107<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>396Met Val Met Pro Glu Ser Ala Met Leu Thr Gly Leu Ile Arg Glu Ala 151015 Gly Gly Thr Pro Val Val Asp Ser Leu Gly Ala Val Gly Thr Ile Thr

20 25 30Ala Asp Pro Glu Gln Val Val Ala Met Ala Pro Glu IleIle Ile Ile

35 40 45Gln Asp Phe Gln Gly Lys Gly Arg Glu Asn Phe Ala Asn Phe Leu Ser

50 55 60Asn Pro Ala Leu Ala Asn Val Pro Ala Ile Glu Asn Asp Lys Ile Phe 65 70 75 80Tyr Ala Asp Thr Val Thr Thr Gly Val Thr Ala Gly Thr Asp Ile Thr

85 90 95Thr Gly Leu Gln Gln Val Ala Glu Met Leu Ser

100105<210>397<211>1479<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<1456><223>RXA02261<400>397gaaatctata gaacgatagg taaaaactgg actaggttta tctatagcgg aatagaaaat 60actccgctcg acagcatcac ttagctgaaa ggcctttaac atg gac ccc tca gat 115

Met Asp Pro Ser Asp

1 5cta gcc tgg att ctc gca gct ttt gcg ttg gta agc ctg atg ttc ccc 163Leu Ala Trp Ile Leu Ala Ala Phe Ala Leu Val Ser Leu Met Phe Pro

10 15 20gga ttg tcc ctg ctc tac ggc ggc atg ctg ggt ggg caa cac gtt ctt 211Gly Leu Ser Leu Leu Tyr Gly Gly Met Leu Gly Gly Gln His Val Leu

25 30 35aac acg ttc atg atg gtt atg agc tca ctt gga atc atc agc ctt gtg 259Asn Thr Phe Met Met Val Met Ser Ser Leu Gly Ile Ile Ser Leu Val

40 45 50tac atc att tat gga cac gga ctt gtc tta gga aac tcc atc ggt ggg 307Tyr Ile Ile Tyr Gly His Gly Leu Val Leu Gly Asn Ser Ile Gly Gly

55 60 65tgg gga att atc ggaaat ccc ctt gaa tac ttc ggc ttc cgc aac att 355Trp Gly Ile Ile Gly Asn Pro Leu Glu Tyr Phe Gly Phe Arg Asn Ile 70 75 80 85atg gaa gat gac ggc acc gga gac ctc atg tgg gcc ggc ttc tac att 403Met Glu Asp Asp Gly Thr Gly Asp Leu Met Trp Ala Gly Phe Tyr Ile

90 95 100ctg ttc gct gca atc tca ctc gca ctt gtt tca tct ggt gca gcg ggg 451Leu Phe Ala Ala Ile Ser Leu Ala Leu Val Ser Ser Gly Ala Ala Gly

105 110 115cgc atg cgc ttt gga gcg tgg ctg gtc ttc ggt gtc ctg tgg ttc acc 499Arg Met Arg Phe Gly Ala Trp Leu Val Phe Gly Val Leu Trp Phe Thr

120 125 130ttt gtg tac gcg cca ctg gca cac tgg gtt ttc gct atc gat gat cct 547Phe Val Tyr Ala Pro Leu Ala His Trp Val Phe Ala Ile Asp Asp Pro

135 140 145gag tcc ggc tac gtg ggt ggc tgg atg aaa aat gtg ctt gag ttc cac 595Glu Ser Gly Tyr Val Gly Gly Trp Met Lys Asn Val Leu Glu Phe His150 155 160 165gac ttt gct ggt gga acg gca gtg cac atg aat gcg ggt gcg tct gga 643Asp Phe Ala Gly Gly Thr Ala Val His Met Asn Ala Gly Ala Ser Gly

170 175 180ctc gcg ctg gca ata gtg ctg gga cgc cgc cac tcc atg gct gtg cgt 691Leu Ala Leu Ala Ile Val Leu Gly Arg Arg His Ser Met Ala Val Arg

185 190 195cca cac aac ctt cca ctg att ttg att ggt gca gga ctg atc gtt gcg 739Pro His Asn Leu Pro Leu Ile Leu Ile Gly Ala Gly Leu Ile Val Ala

200 205 210ggc tgg ttc gga ttc aat ggt ggt acc gca ggt ggt gcc aac ttc ctc 787Gly Trp Phe Gly Phe Asn Gly Gly Thr Ala Gly Gly Ala Asn Phe Leu

215 220 225gca agc tac gtg gtc gtt acc tct ctc att gct gca gct ggc gga atg 835Ala Ser Tyr Val Val Val Thr Ser Leu Ile Ala Ala Ala Gly Gly Met230 235 240 245atg ggc ttc atg ctc gtt gaa cgt gtg ttc agc gga aaa ccc act ttc 883Met Gly Phe Met Leu Val Glu Arg Val Phe Ser Gly Lys Pro Thr Phe

250 255 260ttt ggc tcg gca acc ggc aca atc gca ggc ctt gtg gct atc acc ccg 931Phe Gly Ser Ala Thr Gly Thr Ile Ala Gly Leu Val Ala Ile Thr Pro

265 270 275gcc gcg gat gca gtg agc ccg ctc gga gca ttc gcc gtc gga gcg ctc 979Ala Ala Asp Ala Val Ser Pro Leu Gly Ala Phe Ala Val Gly Ala Leu

280 285 290ggc gca gtt gtc tcc ttc tgg gca att agc tgg aag aag gga cac cga 1027Gly Ala Val Val Ser Phe Trp Ala Ile Ser Trp Lys Lys Gly His Arg

295 300 305gtc gat gat tcc ttc gat gtg ttc gca gtc cac gga atg gcc ggc att 1075Val Asp Asp Ser Phe Asp Val Phe Ala Val His Gly Met Ala Gly Ile310 315 320 325gca ggt gca ctg ttt gtc atg ctc ttt ggc gat cca cta gca cca gcg 1123Ala Gly Ala Leu Phe Val Met Leu Phe Gly Asp Pro Leu Ala Pro Ala

330 335 340gga gtt tcc gga gtc ttc ttc ggt ggc gaa ctc tcc ctg ctg tgg agg 1171Gly Val Ser Gly Val Phe Phe Gly Gly Glu Leu Ser Leu Leu Trp Arg

345 350 355gaa cca ctg gcc atc atc gtg acc ctt aca tac gca ttc ggc gtg acc 1219Glu Pro Leu Ala Ile Ile Val Thr Leu Thr Tyr Ala Phe Gly Val Thr

360 365 370tgg ttg att gcc acgatc ttg aac aag ttc atg act ctg cgc atc acc 1267Trp Leu Ile Ala Thr Ile Leu Asn Lys Phe Met Thr Leu Arg Ile Thr

375 380 385tcc gaa gcc gaa tat gaa ggc att gac cgc gca gaa cac gca gaa tct 1315Ser Glu Ala Glu Tyr Glu Gly Ile Asp Arg Ala Glu His Ala Glu Ser390 395 400 405gcc tac cac ctc aat tcc aac gga att ggg atg gca acc cgc acc aat 1363Ala Tyr His Leu Asn Ser Asn Gly Ile Gly Met Ala Thr Arg Thr Asn

410 415 420ttc gga cct gaa atc ccc gag gaa acc gtg ccc gac gcc gtg cag gtg 1411Phe Gly Pro Glu Ile Pro Glu Glu Thr Val Pro Asp Ala Val Gln Val

425 430 435ggc gtc gat aag caa aaa atc gct gat act cga aag gcc tca aaa 1456Gly Val Asp Lys Gln Lys Ile Ala Asp Thr Arg Lys Ala Ser Lys

440445450 tgaccgcaac ctacaccact gaa 1479<210>398<211>452<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>398Met Asp Pro Ser Asp Leu Ala Trp Ile Leu Ala Ala Phe Ala Leu Val 151015 Ser Leu Met Phe Pro Gly Leu Ser Leu Leu Tyr Gly Gly Met Leu Gly

20 25 30Gly Gln His Val Leu Asn Thr Phe Met Met Val Met Ser Ser Leu Gly

35 40 45Ile Ile Ser Leu Val Tyr Ile Ile Tyr Gly His Gly Leu Val Leu Gly

50 55 60Asn Ser Ile Gly Gly Trp Gly Ile Ile Gly Asn Pro Leu Glu Tyr Phe 65 70 75 80Gly Phe Arg Asn Ile Met Glu Asp Asp Gly Thr Gly Asp Leu Met Trp

85 90 95Ala Gly Phe Tyr Ile Leu Phe Ala Ala Ile Ser Leu Ala Leu Val Ser

100 105 110Ser Gly Ala Ala Gly Arg Met Arg Phe Gly Ala Trp Leu Val Phe Gly

115 120 125Val Leu Trp Phe Thr Phe Val Tyr Ala Pro Leu Ala His Trp Val Phe

130 135 140Ala Ile Asp Asp Pro Glu Ser Gly Tyr Val Gly Gly Trp Met Lys Asn145 150 155 160Val Leu Glu Phe His Asp Phe Ala Gly Gly Thr Ala Val His Met Asn

165 170 175Ala Gly Ala Ser Gly Leu Ala Leu Ala Ile Val Leu Gly Arg Arg His

180 185 190Ser Met Ala Val Arg Pro His Asn Leu Pro Leu Ile Leu Ile Gly Ala

195 200 205Gly Leu Ile Val Ala Gly Trp Phe Gly Phe Asn Gly Gly Thr Ala Gly

210 215 220Gly Ala Asn Phe Leu Ala Ser Tyr Val Val Val Thr Ser Leu Ile Ala22 230 235 240Ala Ala Gly Gly Met Met Gly Phe Met Leu Val Glu Arg Val Phe Ser

245 250 255Gly Lys Pro Thr Phe Phe Gly Ser Ala Thr Gly Thr Ile Ala Gly Leu

260 265 270Val Ala Ile Thr Pro Ala Ala Asp Ala Val Ser Pro Leu Gly Ala Phe

275 280 285Ala Val Gly Ala Leu Gly Ala Val Val Ser Phe Trp Ala Ile Ser Trp

290 295 300Lys Lys Gly His Arg Val Asp Asp Ser Phe Asp Val Phe Ala Val His305 310 315 320Gly Met Ala Gly Ile Ala Gly Ala Leu Phe Val Met Leu Phe Gly Asp

325330 335Pro Leu Ala Pro Ala Gly Val Ser Gly Val Phe Phe Gly Gly Glu Leu

340 345 350Ser Leu Leu Trp Arg Glu Pro Leu Ala Ile Ile Val Thr Leu Thr Tyr

355 360 365Ala Phe Gly Val Thr Trp Leu Ile Ala Thr Ile Leu Asn Lys Phe Met

370 375 380Thr Leu Arg Ile Thr Ser Glu Ala Glu Tyr Glu Gly Ile Asp Arg Ala385 390 395 400Glu His Ala Glu Ser Ala Tyr His Leu Asn Ser Asn Gly Ile Gly Met

405 410 415Ala Thr Arg Thr Asn Phe Gly Pro Glu Ile Pro Glu Glu Thr Val Pro

420 425 430Asp Ala Val Gln Val Gly Val Asp Lys Gln Lys Ile Ala Asp Thr Arg

435 440 445Lys Ala Ser Lys

450<210>399<211>1111<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1111)<223>RXA02020<400>399ttggtcaatc aagcgtgaat ccggcttcca tgagccagtt gcccgcctca aagcttgacc 60cattttcata accagtgcca tgtgggttta cggttgatac atg gct aaa tct aat 115

Met Ala Lys Ser Asn

1 5gaa ggg ctg gga acc gga ctt cgg acc cgc cac ctc aca atg atg gga 163Glu Gly Leu Gly Thr Gly Leu Arg Thr Arg His Leu Thr Met Met Gly

10 15 20ctc ggc tcc gca att ggt gcc gga ctg ttc ctc ggc acc ggc gtt ggt 211Leu Gly Ser Ala Ile Gly Ala Gly Leu Phe Leu Gly Thr Gly Val Gly

25 30 35atc cgc gca gcc ggc ccc gca gtg ctc ctg gcg tac atc atc gcc gga 259Ile Arg Ala Ala Gly Pro Ala Val Leu Leu Ala Tyr Ile Ile Ala Gly

40 45 50gcc atc gtt gtg ctt gtt atg caa atg ctc ggc gag atg gct gct gcc 307Ala Ile Val Val Leu Val Met Gln Met Leu Gly Glu Met Ala Ala Ala

55 60 65cgt ccc gcc tcc gga tcg ttt tca cgt tac ggc gag gat gct ttc ggc 355Arg Pro Ala Ser Gly Ser Phe Ser Arg Tyr Gly Glu Asp Ala Phe Gly 70 75 80 85cac tgg gct ggt ttc tcc ctc ggt tgg ttg tac tgg ttc atg ctg att 403His Trp Ala Gly Phe Ser Leu Gly Trp Leu Tyr Trp Phe Met Leu Ile

90 95 100atg gtg atg ggc gcc gaa atg act ggc gct gct gcc atc atg ggt gca 451Met Val Met Gly Ala Glu Met Thr Gly Ala Ala Ala Ile Met Gly Ala

105 110 115tgg ttc ggc gtc gaa ccg tgg att cct tcg ctt gtc tgc gtg gtc ttc 499Trp Phe Gly Val Glu Pro Trp Ile Pro Ser Leu Val Cys Val Val Phe

120 125 130ttc gct gtg gtg aac ctc gtc gcg gtt cgc ggt ttc ggt gaa ttc gag 547Phe Ala Val Val Asn Leu Val Ala Val Arg Gly Phe Gly Glu Phe Glu

135 140 145tac tgg ttc gca ttc att aag gtc gcg gtg atc atc gct ttc ctc atc 595Tyr Trp Phe Ala Phe Ile Lys Val Ala Val Ile Ile Ala Phe Leu Ile150 155 160 165att ggt att gct ctt att ttc gga tgg ctt ccc gga tcc acc ttt gtt 643Ile Gly Ile Ala Leu Ile Phe Gly Trp Leu Pro Gly Ser Thr Phe Val

170 175 180gga acc tca aac ttc atc ggt gat cac gga ttc atg ccc aat ggtatt 691Gly Thr Ser Asn Phe Ile Gly Asp His Gly Phe Met Pro Asn Gly Ile

185 190 195tct ggt gtt gct gct ggt ttg ctc gcg gtg gct ttt gcc ttt ggt ggc 739Ser Gly Val Ala Ala Gly Leu Leu Ala Val Ala Phe Ala Phe Gly Gly

200 205 210att gaa att gtc acc att gca gct gca gag tcc gat aag cca cgt gaa 787Ile Glu Ile Val Thr Ile Ala Ala Ala Glu Ser Asp Lys Pro Arg Glu

215 220 225gct att tcc ctg gcg gtg cgt gcc gtg att tgg cgt att tca gtc ttt 835Ala Ile Ser Leu Ala Val Arg Ala Val Ile Trp Arg Ile Ser Val Phe230 235 240 245tac ttg ggc tct gtt ttg gtc atc act ttc ctc atg cct tat gag tcg 883Tyr Leu Gly Ser Val Leu Val Ile Thr Phe Leu Met Pro Tyr Glu Ser

250 255 260atc aat ggt gcc gac acc gct gcg gaa tcc ccc ttc acc caa atc ctg 931Ile Asn Gly Ala Asp Thr Ala Ala Glu Ser Pro Phe Thr Gln Ile Leu

265 270 275gcg atg gca aac atc cct ggc acg gtt ggt ttc atg gaa gcg atc atc 979Ala Met Ala Asn Ile Pro Gly Thr Val Gly Phe Met Glu Ala Ile Ile

280 285 290gtt cta gca ctg ctt tcc gct ttc aac gcc caa atc tat gcc act tct 1027Val Leu Ala Leu Leu Ser Ala Phe Asn Ala Gln Ile Tyr Ala Thr Ser

295 300 305cgt ttg gta ttt tcc atg gcg aat cga caa gac gct ccg cga gtt ttc 1075Arg Leu Val Phe Ser Met Ala Asn Arg Gln Asp Ala Pro Arg Val Phe310 315 320 325agt aag ctc agc acc agc cac gtc ccc acc aat gcg 1111Ser Lys Leu Ser Thr Ser His Val Pro Thr Asn Ala

330335<210>400<211>337<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>400Met Ala Lys Ser Asn Glu Gly Leu Gly Thr Gly Leu Arg Thr Arg His 151015 Leu Thr Met Met Gly Leu Gly Ser Ala Ile Gly Ala Gly Leu Phe Leu

20 25 30Gly Thr Gly Val Gly Ile Arg Ala Ala Gly Pro Ala Val Leu Leu Ala

35 40 45Tyr Ile Ile Ala Gly Ala Ile Val Val Leu Val Met Gln Met Leu Gly

50 55 60Glu Met Ala Ala Ala Arg Pro Ala Ser Gly Ser Phe Ser Arg Tyr Gly 65 70 75 80Glu Asp Ala Phe Gly His Trp Ala Gly Phe Ser Leu Gly Trp Leu Tyr

85 90 95Trp Phe Met Leu Ile Met Val Met Gly Ala Glu Met Thr Gly Ala Ala

100 105 110Ala Ile Met Gly Ala Trp Phe Gly Val Glu Pro Trp Ile Pro Ser Leu

115 120 125Val Cys Val Val Phe Phe Ala Val Val Asn Leu Val Ala Val Arg Gly

130 135 140Phe Gly Glu Phe Glu Tyr Trp Phe Ala Phe Ile Lys Val Ala Val Ile145 150 155 160Ile Ala Phe Leu Ile Ile Gly Ile Ala Leu Ile Phe Gly Trp Leu Pro

165 170 175Gly Ser Thr Phe Val Gly Thr Ser Asn Phe Ile Gly Asp His Gly Phe

180 185 190Met Pro Asn Gly Ile Ser Gly Val Ala Ala Gly Leu Leu Ala Val Ala

195 200 205Phe Ala Phe Gly Gly Ile Glu Ile Val Thr Ile Ala Ala Ala Glu Ser

210 215220Asp Lys Pro Arg Glu Ala Ile Ser Leu Ala Val Arg Ala Val Ile Trp225 230 235 240Arg Ile Ser Val Phe Tyr Leu Gly Ser Val Leu Val Ile Thr Phe Leu

245 250 255Met Pro Tyr Glu Ser Ile Asn Gly Ala Asp Thr Ala Ala Glu Ser Pro

260 265 270Phe Thr Gln Ile Leu Ala Met Ala Asn Ile Pro Gly Thr Val Gly Phe

275 280 285Met Glu Ala Ile Ile Val Leu Ala Leu Leu Ser Ala Phe Asn Ala Gln

290 295 300Ile Tyr Ala Thr Ser Arg Leu Val Phe Ser Met Ala Asn Arg Gln Asp305 310 315 320Ala Pro Arg Val Phe Ser Lys Leu Ser Thr Ser His Val Pro Thr Asn

325330335 Ala<210>401<211>784<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (784)<223>RXA00281<400>401ggttgactct ttggctttga tgccagcatt cgccaaagcg tggccctctt taagaaagct 60actgaacaca acagagtagg tttatgcgac actggtgcgc atg arc aac gtt gaa 115

Met Ile Asn Val Glu

1 5ggc ctc acc aaa caa tat ggt cag gtc cgc gca gtc gat gat ctg agc 163Gly Leu Thr Lys Gln Tyr Gly Gln Val Arg Ala Val Asp Asp Leu Ser

10 15 20ttc gaa gta aaa ccc gga ata gtc acc gga ttt Gtc ggc ccc aac ggc 211Phe Glu Val Lys Pro Gly Ile Val Thr Gly Phe Leu Gly Pro Asn Gly

25 30 35gcc gga aaa tcc acc acg atg cgg ctg atc ctt ggc tta gat aat cca 259Ala Gly Lys Ser Thr ThrMet Arg Leu Ile Leu Gly Leu Asp Asn Pro

40 45 50act gca ggg cat gcc acg atc gaa gga caa ccc tac cga tcg ctc aaa 307Thr Ala Gly His Ala Thr Ile Glu Gly Gln Pro Tyr Arg Ser Leu Lys

55 60 65aat ccc ctg acc aaa gtg gga gca ctg ctt gat gcc aaa gca aca cac 355Asn Pro Leu Thr Lys Val Gly Ala Leu Leu Asp Ala Lys Ala Thr His 70 75 80 85cca aat aga aca gca gaa aac cac ctc aag tgg atc gcc cgt gca aat 403Pro Asn Arg Thr Ala Glu Asn His Leu Lys Trp Ile Ala Arg Ala Asn

90 95 100ggg ctg tcc acc aaa aga gtc gat gaa gtt ctc acc ctc gtg gga ctg 451Gly Leu Ser Thr Lys Arg Val Asp Glu Val Leu Thr Leu Val Gly Leu

105 110 115act ggt gtt ggg tca aag aag acc ggt ggg ttt tca cta ggc atg ggc 499Thr Gly Val Gly Ser Lys Lys Thr Gly Gly Phe Ser Leu Gly Met Gly

120 125 130caa cgt cta gga ctt gct gca gca ttg ctc ggc gat ccg gaa tac tta 547Gln Arg Leu Gly Leu Ala Ala Ala Leu Leu Gly Asp Pro Glu Tyr Leu

135 140 145att ctc gac gaa ccc gtc aac ggc ctt gac cca gaa ggc att cac tgg 595Ile Leu Asp Glu Pro Val Asn Gly Leu Asp Pro Glu Gly Ile His Trp150 155 160 165gtg cgc acc ttg ttg caa aac atc gcc aag cag ggc aga acc gtg ctc 643Val Arg Thr Leu Leu Gln Asn Ile Ala Lys Gln Gly Arg Thr Val Leu

170 175 180gtg agt tcc cac ctg ctg tcc gag atg gcg caa act gcg gaa cat ttg 691Val Ser Ser His Leu Leu Ser Glu Met Ala Gln Thr Ala Glu His Leu

185 190195atc gtg att ggg cgt ggc aag ctg gtc gcc gat atg ccc atg cat gag 739Ile Val Ile Gly Arg Gly Lys Leu Val Ala Asp Met Pro Met His Glu

200 205 210ttt gtg cgc tcc cat tcc gct tcc aca gtt gtg gtg cgg gca gca 784Phe Val Arg Ser His Ser Ala Ser Thr Val Val Val Arg Ala Ala

215220225<210>402<211>228<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>402Met Ile Asn Val Glu Gly Leu Thr Lys Gln Tyr Gly Gln Val Arg Ala 151015 Val Asp Asp Leu Ser Phe Glu Val Lys Pro Gly Ile Val Thr Gly Phe

20 25 30Leu Gly Pro Asn Gly Ala Gly Lys Ser Thr Thr Met Arg Leu Ile Leu

35 40 45Gly Leu Asp Asn Pro Thr Ala Gly His Ala Thr Ile Glu Gly Gln Pro

50 55 60Tyr Arg Ser Leu Lys Asn Pro Leu Thr Lys Val Gly Ala Leu Leu Asp 65 70 75 80Ala Lys Ala Thr His Pro Asn Arg Thr Ala Glu Asn His Leu Lys Trp

85 90 95Ile Ala Arg Ala Asn Gly Leu Ser Thr Lys Arg Val Asp Glu Val Leu

100 105 110Thr Leu Val Gly Leu Thr Gly Val Gly Ser Lys Lys Thr Gly Gly Phe

115 120 125Ser Leu Gly Met Gly Gln Arg Leu Gly Leu Ala Ala Ala Leu Leu Gly

130 135 140Asp Pro Glu Tyr Leu Ile Leu Asp Glu Pro Val Asn Gly Leu Asp Pro145 150 155 160Glu Gly Ile His Trp Val Arg Thr Leu Leu Gln Asn Ile Ala Lys Gln

165 170175Gly Arg Thr Val Leu Val Ser Ser His Leu Leu Ser Glu Met Ala Gln

180 185 190Thr Ala Glu His Leu Ile Val Ile Gly Arg Gly Lys Leu Val Ala Asp

195 200 205Met Pro Met His Glu Phe Val Arg Ser His Ser Ala Ser Thr Val Val

210215220 Val Arg Ala Ala225<210>403<211>852<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) }, (852)<223>RXN00570<400>403acg aga cct cgg ccc caa gaa att ggc aac ggg ctt gtc gca ctg att 48Thr Arg Pro Arg Pro Gln Glu Ile Gly Asn Gly Leu Val Ala Leu Ile 151015 ttc tcc gca tcc gga ccc atc gca gtg atc ctg gct gct gct gca gcg 96Phe Ser Ala Ser Gly Pro Ile Ala Val Ile Leu Ala Ala Ala Ala Ala

20 25 30gga aac ctt tcg cct gat caa aca tct tca tgg atc ttc gga gca ttt 144Gly Asn Leu Ser Pro Asp Gln Thr Ser Ser Trp Ile Phe Gly Ala Phe

35 40 45tta ggc aac gga ctg ctc acg ctg tgg ctt acc tat atg tac cgc agc 192Leu Gly Asn Gly Leu Leu Thr Leu Trp Leu Thr Tyr Met Tyr Arg Ser

50 55 60ccg cag gca tac ttc tgg acg att ccc gga acc gtc atc gtg ggc gac 240Pro Gln Ala Tyr Phe Trp Thr Ile Pro Gly Thr Val Ile Val Gly Asp 65 70 75 80tca ctt acc cac tta agt ttc gct gaa gtt atc ggc gca tac ctt gtt 288Ser Leu Thr His Leu Ser Phe Ala Glu Val Ile Gly Ala Tyr Leu Val

85 90 95acc ggc gtt gtg gtg ttt gcg ctc gga tgg acc ggt ctc atc gga cgg 336Thr Gly Val Val Val Phe Ala Leu Gly Trp Thr Gly Leu Ile Gly Arg

100105 110atc atg gcg gta ctg cca cca acc atc gtg atg gcc atg gtc gca ggc 384Ile Met Ala Val Leu Pro Pro Thr Ile Val Met Ala Met Val Ala Gly

115 120 125att ttc ctc cgc ttc gga ctc gac ctc atc gac gcc agc gtg acc gac 432Ile Phe Leu Arg Phe Gly Leu Asp Leu Ile Asp Ala Ser Val Thr Asp

130 135 140ccg ctc att gca ctt ccc atg gtc ata gtt ttt gtg gca ttg agc atg 480Pro Leu Ile Ala Leu Pro Met Val Ile Val Phe Val Ala Leu Ser Met145 150 155 160agt ccc cgc ttg gca agc atc gcc cca ccc gtt gca gta gcc gca gta 528Ser Pro Arg Leu Ala Ser Ile Ala Pro Pro Val Ala Val Ala Ala Val

165 170 175gtg gga acc atc gtt gcc atc gca tcc ggc aaa cta gcg tcc gga att 576Val Gly Thr Ile Val Ala Ile Ala Ser Gly Lys Leu Ala Ser Gly Ile

180 185 190cta gac aac gga att atc tcc cgc ccc gtc ttt acc gcc cca gaa ttt 624Leu Asp Asn Gly Ile Ile Ser Arg Pro Val Phe Thr Ala Pro Glu Phe

195 200 205tcc ttc gcc gcc atc atg gaa ctc gtt gtt ccc ttg gcg atc acc gta 672Ser Phe Ala Ala Ile Met Glu Leu Val Val Pro Leu Ala Ile Thr Val

210 215 220gtc att gtc caa aac ggc caa ggc gtc gca gtg ctt aaa gca gca ggt 720Val Ile Val Gln Asn Gly Gln Gly Val Ala Val Leu Lys Ala Ala Gly225 230 235 240cac cgc ccc gga gta aac ctt gcc gcc gcg gcc tcc gga ctg tgg tcc 768His Arg Pro Gly Val Asn Leu Ala Ala Ala Ala Ser Gly Leu Trp Ser

245 250 255cta ccc atg gcg ttg atc ggc aac atc acc acc tgc ctc acc ggc ccc 816Leu Pro Met Ala Leu Ile Gly Asn Ile ThrThr Cys Leu Thr Gly Pro

260 265 270acc aac gcg ctg atc gtc gcc gga gca aaa tca cac 852Thr Asn Ala Leu Ile Val Ala Gly Ala Lys Ser His

275280<210>404<211>284<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>404Thr Arg Pro Arg Pro Gln Glu Ile Gly Asn Gly Leu Val Ala Leu Ile 151015 Phe Ser Ala Ser Gly Pro Ile Ala Val Ile Leu Ala Ala Ala Ala Ala

20 25 30Gly Asn Leu Ser Pro Asp Gln Thr Ser Ser Trp Ile Phe Gly Ala Phe

35 40 45Leu Gly Asn Gly Leu Leu Thr Leu Trp Leu Thr Tyr Met Tyr Arg Ser

50 55 60Pro Gln Ala Tyr Phe Trp Thr Ile Pro Gly Thr Val Ile Val Gly Asp 65 70 75 80Ser Leu Thr His Leu Ser Phe Ala Glu Val Ile Gly Ala Tyr Leu Val

85 90 95Thr Gly Val Val Val Phe Ala Leu Gly Trp Thr Gly Leu Ile Gly Arg

100 105 110Ile Met Ala Val Leu Pro Pro Thr Ile Val Met Ala Met Val Ala Gly

115 120 125Ile Phe Leu Arg Phe Gly Leu Asp Leu Ile Asp Ala Ser Val Thr Asp

130 135 140Pro Leu Ile Ala Leu Pro Met Val Ile Val Phe Val Ala Leu Ser Met145 150 155 160Ser Pro Arg Leu Ala Ser Ile Ala Pro Pro Val Ala Val Ala Ala Val

165 170 175Val Gly Thr Ile Val Ala Ile Ala Ser Gly Lys Leu Ala Ser Gly Ile

180185 190Leu Asp Asn Gly Ile Ile Ser Arg Pro Val Phe Thr Ala Pro Glu Phe

195 200 205Ser Phe Ala Ala Ile Met Glu Leu Val Val Pro Leu Ala Ile Thr Val

210 215 220Val Ile Val Gln Asn Gly Gln Gly Val Ala Val Leu Lys Ala Ala Gly225 230 235 240His Arg Pro Gly Val Asn Leu Ala Ala Ala Ala Ser Gly Leu Trp Ser

245 250 255Leu Pro Met Ala Leu Ile Gly Asn Ile Thr Thr Cys Leu Thr Gly Pro

260 265 270Thr Asn Ala Leu Ile Val Ala Gly Ala Lys Ser His

275280<210>405<211>498<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (498)<223>FRXA00570<400>405cca acc atc gtg atg gcc atg gtc gca ggc att ttc ctc cgc ttc gga 48Pro Thr Ile Val Met Ala Met Val Ala Gly Ile Phe Leu Arg Phe Gly 151015 ctc gac ctc atc gac gcc agc gtg acc gac ccg ctc att gca ctt ccc 96Leu Asp Leu Ile Asp Ala Ser Val Thr Asp Pro Leu Ile Ala Leu Pro

20 25 30atg gtc ata gtt ttt gtg gca ttg agc atg agt ccc cgc ttg gca agc 144Met Val Ile Val Phe Val Ala Leu Ser Met Ser Pro Arg Leu Ala Ser

35 40 45atc gcc cca ccc gtt gca gta gcc gca gta gtg gga acc atc gtt gcc 192Ile Ala Pro Pro Val Ala Val Ala Ala Val Val Gly Thr Ile Val Ala

50 55 60atc gca tcc ggc aaa cta gcg tcc gga att cta gac aac gga att atc 240Ile Ala Ser Gly Lys Leu Ala Ser Gly Ile Leu Asp Asn Gly Ile Ile 65 70 75 80tcc cgc ccc gtc ttt acc gcc cca gaa ttt tcc ttc gcc gcc atc atg 288Ser Arg Pro Val Phe Thr Ala Pro Glu Phe Ser Phe Ala Ala Ile Met

85 90 95gaa ctc gtt gtt ccc ttg gcg atc acc gta gtc att gtc caa aac ggc 336Glu Leu Val Val Pro Leu Ala Ile Thr Val Val Ile Val Gln Asn Gly

100 105 110caa ggc gtc gca gtg ctt aaa gca gca ggt cac cgc ccc gga gta aac 384Gln Gly Val Ala Val Leu Lys Ala Ala Gly His Arg Pro Gly Val Asn

115 120 125ctt gcc gcc gcg gcc tcc gga ctg tgg tcc cta ccc atg gcg ttg atc 432Leu Ala Ala Ala Ala Ser Gly Leu Trp Ser Leu Pro Met Ala Leu Ile

130 135 140ggc aac atc acc acc tgc ctc acc ggc ccc acc aac gcg ctg atc gtc 480Gly Asn Ile Thr Thr Cys Leu Thr Gly Pro Thr Asn Ala Leu Ile Val145 150 155 160gcc gga gca aaa tca cac 498Ala Gly Ala Lys Ser His

165<210>406<211>166<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>406Pro Thr Ile Val Met Ala Met Val Ala Gly Ile Phe Leu Arg Phe Gly 151015 Leu Asp Leu Ile Asp Ala Ser Val Thr Asp Pro Leu Ile Ala Leu Pro

20 25 30Met Val Ile Val Phe Val Ala Leu Ser Met Ser Pro Arg Leu Ala Ser

35 40 45Ile Ala Pro Pro Val Ala Val Ala Ala Val Val Gly Thr Ile Val Ala

50 55 60Ile Ala Ser Gly Lys Leu Ala Ser Gly Ile Leu Asp Asn Gly Ile Ile 65 70 75 80Ser Arg Pro Val Phe Thr Ala Pro Glu Phe Ser Phe Ala Ala Ile Met

85 90 95Glu Leu Val Val Pro Leu Ala Ile Thr Val Val Ile Val Gln Asn Gly

100 105 110Gln Gly Val Ala Val Leu Lys Ala Ala Gly His Arg Pro Gly Val Asn

115 120 125Leu Ala Ala Ala Ala Ser Gly Leu Trp Ser Leu Pro Met Ala Leu Ile

130 135 140Gly Asn Ile Thr Thr Cys Leu Thr Gly Pro Thr Asn Ala Leu Ile Val145 150 155 160Ala Gly Ala Lys Ser His

165<210>407<211>1280<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (1257)<223>RXN00571<400>407aca ctt gtt cca cag gtt tac gaa ata gtg atc tac ggc gct gtg ctg 48Thr Leu Val Pro Gln Val Tyr Glu Ile Val Ile Tyr Gly Ala Val Leu 151015 tca gct gta cat gaa gat cca acc cag atc ggt gcg ctc agc cca gca 96Ser Ala Val His Glu Asp Pro Thr Gln Ile Gly Ala Leu Ser Pro Ala

20 25 30gtc gcc ggc acc ctt ggt tcc tac gcc atg atc ggc gtg atg atc ggt 144Val Ala Gly Thr Leu Gly Ser Tyr Ala Met Ile Gly Val Met Ile Gly

35 40 45gct cta tct gca ggt gcc gtt ggt gac cgc ctt ggt cgt cgc aaa gtt 192Ala Leu Ser Ala Gly Ala Val Gly Asp Arg Leu Gly Arg Arg Lys Val

50 55 60atg ctc acc gca atc gtc tgg ttc tct gtg ggc atg gcg ctg acc gcg 240Met Leu Thr Ala Ile Val Trp Phe Ser Val Gly Met Ala Leu Thr Ala 65 70 75 80ttc gcg tcc tcg att gcg ctg ttc ggt ttc ttg cgc ttc ctc acc gga 288Phe Ala Ser Ser Ile Ala Leu Phe Gly Phe Leu Arg Phe Leu Thr Gly

85 90 95ctt ggc gtg ggc atg atc gtt gca acc ggc ggc gca atc atc gcg gag 336Leu Gly Val Gly Met Ile Val Ala Thr Gly Gly Ala Ile Ile Ala Glu

100 105 110ttc gct cca gcg aat agg cgc aac ttg ttc aac gca atc gtg tac tcc 384Phe Ala Pro Ala Asn Arg Arg Asn Leu Phe Asn Ala Ile Val Tyr Ser

115 120 125ggt gtc cca gcc ggt ggc gtg ctg gct tct atc ctt gca ctg ctc ttt 432Gly Val Pro Ala Gly Gly Val Leu Ala Ser Ile Leu Ala Leu Leu Phe

130 135 140gaa gat gtc atc ggc tgg cgc gga ctc ttc ctc atc ggt gga tcc cca 480Glu Asp Val Ile Gly Trp Arg Gly Leu Phe Leu Ile Gly Gly Ser Pro145 150 155 160cta ctg ttc ctc ctg cca ctt gca tac ttc ttc ctc cca gag tcc ccg 528Leu Leu Phe Leu Leu Pro Leu Ala Tyr Phe Phe Leu Pro Glu Ser Pro

165 170 175cgc tgg ctc acc tcc cgc ggc cgt gct gcg gac gcc aaa gcc ctc tgc 576Arg Trp Leu Thr Ser Arg Gly Arg Ala Ala Asp Ala Lys Ala Leu Cys

180 185 190gca cgc tat ggg ctg ccg acg gag gaa ttt gtc gtc gaa aag cag cag 624Ala Arg Tyr Gly Leu Pro Thr Glu Glu Phe Val Val Glu Lys Gln Gln

195 200 205gaa aca aag ggc acc gga ttc gct gga att ttc tcc tcc aag tac ctc 672Glu Thr Lys Gly Thr Gly Phe Ala Gly Ile Phe Ser Ser Lys Tyr Leu

210 215 220atg ggc acc att ctc atc ggc gca atg agc ttc atc ggg ctg ctt tcg 720Met Gly Thr Ile Leu Ile Gly Ala Met Ser Phe Ile Gly Leu Leu Ser225 230 235 240acc tac ggc ctg aac acc tgg ttg cca aag atc atggaa tcc aac ggc 768Thr Tyr Gly Leu Asn Thr Trp Leu Pro Lys Ile Met Glu Ser Asn Gly

245 250 255gca acc tca cat gat tcc ctg tac tcc ctg ctg ttc ctc aac ggc ggc 816Ala Thr Ser His Asp Ser Leu Tyr Ser Leu Leu Phe Leu Asn Gly Gly

260 265 270gca gtg ttc ggt ggc ctc atc gca tcc tgg ttc gct gac cgc atc ggc 864Ala Val Phe Gly Gly Leu Ile Ala Ser Trp Phe Ala Asp Arg Ile Gly

275 280 285gcg aag acc gtg atc acc tcc acc ttc gct ctc gcc gcg atc tgc ctc 912Ala Lys Thr Val Ile Thr Ser Thr Phe Ala Leu Ala Ala Ile Cys Leu

290 295 300gga gtc ctg cca aac atc tcc tcc tgg cca atg atg tac acc gca atc 960Gly Val Leu Pro Asn Ile Ser Ser Trp Pro Met Met Tyr Thr Ala Ile305 310 315 320gca ttc gca ggc gtc ggc gtc ctg ggc acc cag gtt ctc acc tac ggc 1008Ala Phe Ala Gly Val Gly Val Leu Gly Thr Gln Val Leu Thr Tyr Gly

325 330 335ctg acc tcg aac ttc ttc gga acc gaa tgc cgc gca gcg gga gtt gca 1056Leu Thr Ser Asn Phe Phe Gly Thr Glu Cys Arg Ala Ala Gly Val Ala

340 345 350tgg tgt gca gga ttc ggc cga ctc ggc gga atc gtc gga cca gca atc 1104Trp Cys Ala Gly Phe Gly Arg Leu Gly Gly Ile Val Gly Pro Ala Ile

355 360 365ggt ggc ctg atc atc ggc gca gga ttc gga cca agc tcc gca ttc ctc 1152Gly Gly Leu Ile Ile Gly Ala Gly Phe Gly Pro Ser Ser Ala Phe Leu

370 375 380atc ttc gca gca gct gcc gca atc ggc gcg gtc tgc acc ttg ctg atc 1200Ile Phe Ala Ala Ala Ala Ala Ile Gly Ala Val Cys Thr Leu Leu Ile385 390395 400ccg cgc tcc cca gca gaa gta gag gtc aag gtc gcg cag gaa cca ctt 1248Pro Arg Ser Pro Ala Glu Val Glu Val Lys Val Ala Gln Glu Pro Leu

405 410 415gca cgt gtc taaccccaat taattcgaaa caa 1280Ala Arg Val<210>408<211>419<212>PRT

<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>408Thr Leu Val Pro Gln Val Tyr Glu Ile Val Ile Tyr Gly Ala Val Leu 151015 Ser Ala Val His Glu Asp Pro Thr Gln Ile Gly Ala Leu Ser Pro Ala

20 25 30Val Ala Gly Thr Leu Gly Ser Tyr Ala Met Ile Gly Val Met Ile Gly

35 40 45Ala Leu Ser Ala Gly Ala Val Gly Asp Arg Leu Gly Arg Arg Lys Val

50 55 60Met Leu Thr Ala Ile Val Trp Phe Ser Val Gly Met Ala Leu Thr Ala 65 70 75 80Phe Ala Ser Ser Ile Ala Leu Phe Gly Phe Leu Arg Phe Leu Thr Gly

85 90 95Leu Gly Val Gly Met Ile Val Ala Thr Gly Gly Ala Ile Ile Ala Glu

100 105 110Phe Ala Pro Ala Asn Arg Arg Asn Leu Phe Asn Ala Ile Val Tyr Ser

115 120 125Gly Val Pro Ala Gly Gly Val Leu Ala Ser Ile Leu Ala Leu Leu Phe

130 135 140Glu Asp Val Ile Gly Trp Arg Gly Leu Phe Leu Ile Gly Gly Ser Pro145 150 155 160Leu Leu Phe Leu Leu Pro Leu Ala Tyr Phe Phe Leu Pro Glu Ser Pro

165 170 175Arg TrpLeu Thr Ser Arg Gly Arg Ala Ala Asp Ala Lys Ala Leu Cys

180 185 190Ala Arg Tyr Gly Leu Pro Thr Glu Glu Phe Val Val Glu Lys Gln Gln

195 200 205Glu Thr Lys Gly Thr Gly Phe Ala Gly Ile Phe Ser Ser Lys Tyr Leu

210 215 220Met Gly Thr Ile Leu Ile Gly Ala Met Ser Phe Ile Gly Leu Leu Ser225 230 235 240Thr Tyr Gly Leu Asn Thr Trp Leu Pro Lys Ile Met Glu Ser Asn Gly

245 250 255Ala Thr Ser His Asp Ser Leu Tyr Ser Leu Leu Phe Leu Asn Gly Gly

260 265 270Ala Val Phe Gly Gly Leu Ile Ala Ser Trp Phe Ala Asp Arg Ile Gly

275 280 285Ala Lys Thr Val Ile Thr Ser Thr Phe Ala Leu Ala Ala Ile Cys Leu

290 295 300Gly Val Leu Pro Asn Ile Ser Ser Trp Pro Met Met Tyr Thr Ala Ile305 310 315 320Ala Phe Ala Gly Val Gly Val Leu Gly Thr Gln Val Leu Thr Tyr Gly

325 330 335Leu Thr Ser Asn Phe Phe Gly Thr Glu Cys Arg Ala Ala Gly Val Ala

340 345 350Trp Cys Ala Gly Phe Gly Arg Leu Gly Gly Ile Val Gly Pro Ala Ile

355 360 365Gly Gly Leu Ile Ile Gly Ala Gly Phe Gly Pro Ser Ser Ala Phe Leu

370 375 380Ile Phe Ala Ala Ala Ala Ala Ile Gly Ala Val Cys Thr Leu Leu Ile385 390 395 400Pro Arg Ser Pro Ala Glu Val Glu Val Lys Val Ala Gln Glu Pro Leu

405410415 Ala Arg Val<210>409<211>1208<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (1185)<223>FRXA00571<400>409cag atc ggt gcg ctc agc cca gca gtc gcc ggc acc ctt ggt tcc tac 48Gln Ile Gly Ala Leu Ser Pro Ala Val Ala Gly Thr Leu Gly Ser Tyr 151015 gcc atg atc ggc gtg atg atc ggt gct cta tct gca ggt gcc gtt ggt 96Ala Met Ile Gly Val Met Ile Gly Ala Leu Ser Ala Gly Ala Val Gly

20 25 30gac cgc ctt ggt cgt cgc aaa gtt atg ctc acc gca atc gtc tgg ttc 144Asp Arg Leu Gly Arg Arg Lys Val Met Leu Thr Ala Ile Val Trp Phe

35 40 45tct gtg ggc atg gcg ctg acc gcg ttc gcg tcc tcg att gcg ctg ttc 192Ser Val Gly Met Ala Leu Thr Ala Phe Ala Ser Ser Ile Ala Leu Phe

50 55 60ggt ttc ttg cgc ttc ctc acc gga ctt ggc gtg ggc atg atc gtt gca 240Gly Phe Leu Arg Phe Leu Thr Gly Leu Gly Val Gly Met Ile Val Ala 65 70 75 80acc ggc ggc gca atc atc gcg gag ttc gct cca gcg aat agg cgc aac 288Thr Gly Gly Ala Ile Ile Ala Glu Phe Ala Pro Ala Asn Arg Arg Asn

85 90 95ttg ttc aac gca atc gtg tac tcc ggt gtc cca gcc ggt ggc gtg ctg 336Leu Phe Asn Ala Ile Val Tyr Ser Gly Val Pro Ala Gly Gly Val Leu

100 105 110gct tct atc ctt gca ctg ctc ttt gaa gat gtc atc ggc tgg cgc gga 384Ala Ser Ile Leu Ala Leu Leu Phe Glu Asp Val Ile Gly Trp Arg Gly

115 120 125ctc ttc ctc atc ggt gga tcc cca cta ctg ttc ctc ctg cca ctt gca 432Leu Phe Leu Ile Gly Gly Ser ProLeu Leu Phe Leu Leu Pro Leu Ala

130 135 140tac ttc ttc ctc cca gag tcc ccg cgc tgg ctc acc tcc cgc ggc cgt 480Tyr Phe Phe Leu Pro Glu Ser Pro Arg Trp Leu Thr Ser Arg Gly Arg145 150 155 160gct gcg gac gcc aaa gcc ctc tgc gca cgc tat ggg ctg ccg acg gag 528Ala Ala Asp Ala Lys Ala Leu Cys Ala Arg Tyr Gly Leu Pro Thr Glu

165 170 175gaa ttt gtc gtc gaa aag cag cag gaa aca aag ggc acc gga ttc gct 576Glu Phe Val Val Glu Lys Gln Gln Glu Thr Lys Gly Thr Gly Phe Ala

180 185 190gga att ttc tcc tcc aag tac ctc atg ggc acc att ctc atc ggc gca 624Gly Ile Phe Ser Ser Lys Tyr Leu Met Gly Thr Ile Leu Ile Gly Ala

195 200 205atg agc ttc atc ggg ctg ctt tcg acc tac ggc ctg aac acc tgg ttg 672Met Ser Phe Ile Gly Leu Leu Ser Thr Tyr Gly Leu Asn Thr Trp Leu

210 215 220cca aag atc atg gaa tcc aac ggc gca acc tca cat gat tcc ctg tac 720Pro Lys Ile Met Glu Ser Asn Gly Ala Thr Ser His Asp Ser Leu Tyr225 230 235 240tcc ctg ctg ttc ctc aac ggc ggc gca gtg ttc ggt ggc ctc atc gca 768Ser Leu Leu Phe Leu Asn Gly Gly Ala Val Phe Gly Gly Leu Ile Ala

245 250 255tcc tgg ttc gct gac cgc atc ggc gcg aag acc gtg atc acc tcc acc 816Ser Trp Phe Ala Asp Arg Ile Gly Ala Lys Thr Val Ile Thr Ser Thr

260 265 270ttc gct ctc gcc gcg atc tgc ctc gga gtc ctg cca aac atc tcc tcc 864Phe Ala Leu Ala Ala Ile Cys Leu Gly Val Leu Pro Asn Ile Ser Ser

275 280 285tgg cca atg atg tac accgca atc gca ttc gca ggc gtc ggc gtc ctg 912Trp Pro Met Met Tyr Thr Ala Ile Ala Phe Ala Gly Val Gly Val Leu

290 295 300ggc acc cag gtt ctc acc tac ggc ctg acc tcg aac ttc ttc gga acc 960Gly Thr Gln Val Leu Thr Tyr Gly Leu Thr Ser Asn Phe Phe Gly Thr305 310 315 320gaa tgc cgc gca gcg gga gtt gca tgg tgt gca gga ttc ggc cga ctc 1008Glu Cys Arg Ala Ala Gly Val Ala Trp Cys Ala Gly Phe Gly Arg Leu

325 330 335ggc gga atc gtc gga cca gca atc ggt ggc ctg atc atc ggc gca gga 1056Gly Gly Ile Val Gly Pro Ala Ile Gly Gly Leu Ile Ile Gly Ala Gly

340 345 350ttc gga cca agc tcc gca ttc ctc atc ttc gca gca gct gcc gca atc 1104Phe Gly Pro Ser Ser Ala Phe Leu Ile Phe Ala Ala Ala Ala Ala Ile

355 360 365ggc gcg gtc tgc acc ttg ctg atc ccg cgc tcc cca gca gaa gta gag 1152Gly Ala Val Cys Thr Leu Leu Ile Pro Arg Ser Pro Ala Glu Val Glu

370375380 gtc aag gtc gcg cag gaa cca ctt gca cgt gtc taaccccaat taattcgaaa 1205Val Lys Val Ala Gln Glu Pro Leu Ala Arg Val 385390395 caa1208<210>410<211>395<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>410Gln Ile Gly Ala Leu Ser Pro Ala Val Ala Gly Thr Leu Gly Ser Tyr 151015 Ala Met Ile Gly Val Met Ile Gly Ala Leu Ser Ala Gly Ala Val Gly

20 25 30Asp Arg Leu Gly Arg Arg Lys Val Met Leu Thr Ala Ile Val Trp Phe

35 40 45Ser Val Gly Met Ala Leu Thr Ala Phe Ala Ser Ser Ile Ala Leu Phe

50 55 60Gly Phe Leu Arg Phe Leu Thr Gly LeuGly Val Gly Met Ile Val Ala 65 70 75 80Thr Gly Gly Ala Ile Ile Ala Glu Phe Ala Pro Ala Asn Arg Arg Asn

85 90 95Leu Phe Asn Ala Ile Val Tyr Ser Gly Val Pro Ala Gly Gly Val Leu

100 105 110Ala Ser Ile Leu Ala Leu Leu Phe Glu Asp Val Ile Gly Trp Arg Gly

115 120 125Leu Phe Leu Ile Gly Gly Ser Pro Leu Leu Phe Leu Leu Pro Leu Ala

130 135 140Tyr Phe Phe Leu Pro Glu Ser Pro Arg Trp Leu Thr Ser Arg Gly Arg145 150 155 160Ala Ala Asp Ala Lys Ala Leu Cys Ala Arg Tyr Gly Leu Pro Thr Glu

165 170 175Glu Phe Val Val Glu Lys Gln Gln Glu Thr Lys Gly Thr Gly Phe Ala

180 185 190Gly Ile Phe Ser Ser Lys Tyr Leu Met Gly Thr Ile Leu Ile Gly Ala

195 200 205Met Ser Phe Ile Gly Leu Leu Ser Thr Tyr Gly Leu Asn Thr Trp Leu

210 215 220Pro Lys Ile Met Glu Ser Asn Gly Ala Thr Ser His Asp Ser Leu Tyr225 230 235 240Ser Leu Leu Phe Leu Asn Gly Gly Ala Val Phe Gly Gly Leu Ile Ala

245 250 255Ser Trp Phe Ala Asp Arg Ile Gly Ala Lys Thr Val Ile Thr Ser Thr

260 265 270Phe Ala Leu Ala Ala Ile Cys Leu Gly Val Leu Pro Asn Ile Ser Ser

275 280 285Trp Pro Met Met Tyr Thr Ala Ile Ala Phe Ala Gly Val Gly Val Leu

290 295 300Gly Thr Gln Val Leu Thr Tyr Gly Leu Thr Ser Asn Phe Phe Gly Thr305 310 315 320Glu Cys Arg Ala Ala Gly Val Ala Trp Cys Ala Gly Phe Gly Arg Leu

325 330 335Gly Gly Ile Val Gly Pro Ala Ile Gly Gly Leu Ile Ile Gly Ala Gly

340 345 350Phe Gly Pro Ser Ser Ala Phe Leu Ile Phe Ala Ala Ala Ala Ala Ile

355 360 365Gly Ala Val Cys Thr Leu Leu Ile Pro Arg Ser Pro Ala Glu Val Glu

370375380 Val Lys Val Ala Gln Glu Pro Leu Ala Arg Val 385390395<210>411<211>689<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (666)<223>RXA00962<400>411gat aag gcc atc aag gcg gat cac gac att aga gaa ggc cac gat gag 48Asp Lys Ala Ile Lys Ala Asp His Asp Ile Arg Glu Gly His Asp Glu 151015 cca gca ggt ttc aag gat ctg ctt gtc gat cgc tac cgc tgg atc tcc 96Pro Ala Gly Phe Lys Asp Leu Leu Val Asp Arg Tyr Arg Trp Ile Ser<25>-CDS<1>-666

20 25 30att tgg ttc gcg ctc gcc aca ttt gtc acc ctg ctc gcg tgg tac gga 144 Ile Trp Phe Ala Leu Ala Thr Phe Val Thr Leu Leu Ala Trp Tyr Gly

35 40 45ctg ggc aca tgg ttg cct cgc ctc atg gaa act gca ggt tat gag ttc 192Leu Gly Thr Trp Leu Pro Arg Leu Met Glu Thr Ala Gly Tyt Glu Phe

50 55 60ggc cat gca ttg atg ttc acc ctg gct ctg aac ctc ggt gca gtg atc 240Gly His Ala Leu Met Phe Thr Leu Ala Leu Asn Leu Gly Ala Val Ile 65 70 7580gga tcc gtg gtt act gcg tgg gcc ggc gat cgc ttc ggg cca atc cgt 288Gly Ser Val Val Thr Ala Trp Ala Gly Asp Arg Phe Gly Pro Ile Arg

85 90 95tcc ggt gtc atc gct gca ggt atc gcc ggt att gca ctg ctc ctg ctg 336Ser Gly Val Ile Ala Ala Gly Ile Ala Gly Ile Ala Leu Leu Leu Leu

100 105 110ctc act tac ccg cct gtc acc gcg gtt tat gtc att ctc att ttg gct 384Leu Thr Tyr Pro Pro Val Thr Ala Val Tyr Val Ile Leu Ile Leu Ala

115 120 125ggc gtg ggc acc cac ggc act cag atc ctc atc att gca gct gtc gcc 432Gly Val Gly Thr His Gly Thr Gln Ile Leu Ile Ile Ala Ala Val Ala

130 135 140aac ttc tac cca agc aac ctg cgt ggc aca gca ctg ggc tgg gcg cta 480Asn Phe Tyr Pro Ser Asn Leu Arg Gly Thr Ala Leu Gly Trp Ala Leu145 150 155 160ggt gta ggt cgt att ggt gct gtt gtg gcc ccg cag ctc gct ggc ctg 528Gly Val Gly Arg Ile Gly Ala Val Val Ala Pro Gln Leu Ala Gly Leu

165 170 175ctg ctg gca tgg aac ttg ggc gtg aac tcc aac ttc atc atg ttc ggc 576Leu Leu Ala Trp Asn Leu Gly Val Asn Ser Asn Phe Ile Met Phe Gly

180 185 190acc gct gcg ctg ctc tct gcg ctg gct ctc agc gtg ttg ctg cgc ctg 624Thr Ala Ala Leu Leu Ser Ala Leu Ala Leu Ser Val Leu Leu Arg Leu

195 200 205cag aaa acc tac agc gtc acc cac aaa gtc gaa atc caa ggc 666Gln Lys Thr Tyr Ser Val Thr His Lys Val Glu Ile Gln Gly

210215220 taaccccctt tttcaactca cag 689<210>412<211>222<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>412Asp Lys Ala Ile Lys Ala Asp His Asp Ile Arg Glu Gly His Asp Glu 151015 Pro Ala Gly Phe Lys Asp Leu Leu Val Asp Arg Tyr Arg Trp Ile Ser

20 25 30Ile Trp Phe Ala Leu Ala Thr Phe Val Thr Leu Leu Ala Trp Tyr Gly

35 40 45Leu Gly Thr Trp Leu Pro Arg Leu Met Glu Thr Ala Gly Tyr Glu Phe

50 55 60Gly His Ala Leu Met Phe Thr Leu Ala Leu Asn Leu Gly Ala Val Ile 65 70 75 80Gly Ser Val Val Thr Ala Trp Ala Gly Asp Arg Phe Gly Pro Ile Arg

85 90 95Ser Gly Val Ile Ala Ala Gly Ile Ala Gly Ile Ala Leu Leu Leu Leu

100 105 110Leu Thr Tyr Pro Pro Val Thr Ala Val Tyr Val Ile Leu Ile Leu Ala

115 120 125Gly Val Gly Thr His Gly Thr Gln Ile Leu Ile Ile Ala Ala Val Ala

130 135 140Asn Phe Tyr Pro Ser Asn Leu Arg Gly Thr Ala Leu Gly Trp Ala Leu145 150 155 160Gly Val Gly Arg Ile Gly Ala Val Val Ala Pro Gln Leu Ala Gly Leu

165 170 175Leu Leu Ala Trp Asn Leu Gly Val Asn Ser Asn Phe Ile Met Phe Gly

180 185 190Thr Ala Ala Leu Leu Ser Ala Leu Ala Leu Ser Val Leu Leu Arg Leu

195 200 205Gln Lys Thr Tyr Ser Val Thr His Lys Val Glu Ile Gln Gly

210215220<210>413<211>484<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (484)<223>RXA02811<400>413cataatcact ctttccagat agcggaatcc ctttgattgt aacttggctc acctcgatta 60tgtgtttatg acatcacacg caccagaatc gggaggactt gtg aca gag tca act 115

Val Thr Glu Ser Thr

1 5ctc gga gca tcg aat agc tcc caa aca att gaa aat aaa ggc ctc acc 163Leu Gly Ala Ser Asn Ser Ser Gln Thr Ile Glu Asn Lys Gly Leu Thr

10 15 20atc ttg ggc atc agc ggc cga cgc ttg gct gcg gtg ctc att ggc tgg 211Ile Leu Gly Ile Ser Gly Arg Arg Leu Ala Ala Val Leu Ile Gly Trp

25 30 35ttt ttt gtc att ttc gac ggc tac gac ctc att gtg tac ggc acc gtc 259Phe Phe Val Ile Phe Asp Gly Tyr Asp Leu Ile Val Tyr Gly Thr Val

40 45 50caa tcg gcc ctg gct aag gag tgg aac tta agc tct gca acg ctg ggc 307Gln Ser Ala Leu Ala Lys Glu Trp Asn Leu Ser Ser Ala Thr Leu Gly

55 60 65acc atc ggc tcc acc gcg ttc ttt ggc atg gcg atc ggc gct gtg ttc 355Thr Ile Gly Ser Thr Ala Phe Phe Gly Met Ala Ile Gly Ala Val Phe 70 75 80 85att ggt cga ctg tca gac cgc gtg ggc cga aaa gca gcg gtg att gga 403Ile Gly Arg Leu Ser Asp Arg Val Gly Arg Lys Ala Ala Val Ile Gly

90 95 100tcc gtg ctg att ctc tct gtc ttc acc atg ctg tgt gca ttt gct cca 451Ser Val Leu Ile Leu Ser Val Phe Thr Met Leu Cys Ala Phe Ala Pro

105 110 115aac cca tgg gtg ttc ggc gct ttc cgt ttc atc 484Asn Pro Trp Val Phe Gly Ala Phe Arg Phe Ile

120125<210>414<211>128<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>414Val Thr Glu Ser Thr Leu Gly Ala Ser Asn Ser Ser Gln Thr Ile Glu 151015 Asn Lys Gly Leu Thr Ile Leu Gly Ile Ser Gly Arg Arg Leu Ala Ala

20 25 30Val Leu Ile Gly Trp Phe Phe Val Ile Phe Asp Gly Tyr Asp Leu Ile

35 40 45Val Tyr Gly Thr Val Gln Ser Ala Leu Ala Lys Glu Trp Asn Leu Ser

50 55 60Ser Ala Thr Leu Gly Thr Ile Gly Ser Thr Ala Phe Phe Gly Met Ala 65 70 75 80Ile Gly Ala Val Phe Ile Gly Arg Leu Ser Asp Arg Val Gly Arg Lys

85 90 95Ala Ala Val Ile Gly Ser Val Leu Ile Leu Ser Val Phe Thr Met Leu

100 105 110Cys Ala Phe Ala Pro Asn Pro Trp Val Phe Gly Ala Phe Arg Phe Ile

115120125<210>415<211>1197<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (1197)<223>RXA02115<400>415acc cgc gca acc aaa agt gtc gga aca gtt ctc gca ctc ctg tgg ttc 48Thr Arg Ala Thr Lys Ser Val Gly Thr Val Leu Ala Leu Leu Trp Phe 151015 gca att gtc ctc gac ggc ttt gac cta gtc gtc ctg ggt gca aca atc 96Ala Ile Val Leu Asp Gly Phe Asp Leu Val Val Leu Gly Ala Thr Ile<400>-415<32>Thr Arg Ala Thr Lys Ser Val Gly Thr Val Leu Ala Leu Leu Trp Phe 35015

20 25 30ccg tcc atg ctg gag gat ccc gcg tgg gat ctc act gct gga cag gcc 144Pro Ser Met Leu Glu Asp Pro Ala Trp Asp Leu Thr Ala Gly GlnAla

35 40 45aca cag att tcc acc atc ggc ctc gtc ggc atg acc att ggc gca ctg 192Thr Gln Ile Ser Thr Ile Gly Leu Val Gly Met Thr Ile Gly Ala Leu

50 55 60acc atc ggt ttc tta acg gac cgt ctg ggt cga cgc cgt gtc atg ctg 240Thr Ile Gly Phe Leu Thr Asp Arg Leu Gly Arg Arg Arg Val Met Leu 65 70 75 80ttc tct gtg gca gta ttt tct gta ttc act ctc ctg ctg gca ttc acc 288Phe Ser Val Ala Val Phe Ser Val Phe Thr Leu Leu Leu Ala Phe Thr

85 90 95acc aac gtc cag ctc ttc agc ctg tgg cgt ttc ctc gca ggt gtt ggc 336Thr Asn Val Gln Leu Phe Ser Leu Trp Arg Phe Leu Ala Gly Val Gly

100 105 110ctt ggt gga gca ctc ccc acc gca att gcc atg gtg acc gag ttc cgc 384Leu Gly Gly Ala Leu Pro Thr Ala Ile Ala Met Val Thr Glu Phe Arg

115 120 125ccc ggc acc aaa gcg ggc tct gca tcc acc acc ttg atg acc ggc tac 432Pro Gly Thr Lys Ala Gly Ser Ala Ser Thr Thr Leu Met Thr Gly Tyr

130 135 140cac gtc ggc gca gta gca acc gcc ttc ctt ggc ctc ttc ctt atc gac 480His Val Gly Ala Val Ala Thr Ala Phe Leu Gly Leu Phe Leu Ile Asp145 150 155 160ggc ttt ggt tgg cac tcc atg ttc atc gca ggt gcc gta cca gga ctg 528Gly Phe Gly Trp His Ser Met Phe Ile Ala Gly Ala Val Pro Gly Leu

165 170 175atc ctg cta cca ctg ctg tac ttc ttc ctt cca gaa tcc ccg cag tac 576Ile Leu Leu Pro Leu Leu Tyr Phe Phe Leu Pro Glu Ser Pro Gln Tyr

180 185 190ctc aaa atc tcc ggc aag ttg gat gag gcg cag gca gtt gca gca tct 624Leu Lys Ile Ser Gly Lys Leu Asp Glu Ala Gln Ala Val Ala Ala Ser

195 200 205tat gga ctt tcc ctg gat gat gat ctt gat cgc gaa cac gaa gaa gaa 672Tyr Gly Leu Ser Leu Asp Asp Asp Leu Asp Arg Glu His Glu Glu Glu

210 215 220ctc ggc gag tcc tcc tca ctt tcc tcc ctg ttc aag ccc tcg ttc cgc 720Leu Gly Glu Ser Ser Ser Leu Ser Ser Leu Phe Lys Pro Ser Phe Arg225 230 235 240cgc aac acc ctg gcg att tgg ggc acc tca ttc atg gga ctc ctc ctg 768Arg Asn Thr Leu Ala Ile Trp Gly Thr Ser Phe Met Gly Leu Leu Leu

245 250 255gtc tac ggc ctg aac aca tgg ctg cca caa atc atg cgc caa gca gac 816Val Tyr Gly Leu Asn Thr Trp Leu Pro Gln Ile Met Arg Gln Ala Asp

260 265 270tac gac atg ggt aac tcg ctt gga ttc ctc atg gtg ctc aac atc ggc 864Tyr Asp Met Gly Asn Ser Leu Gly Phe Leu Met Val Leu Asn Ile Gly

275 280 285gca gtg atc ggc ctt tat att gca ggg cga att gcc gat aag aac tcc 912Ala Val Ile Gly Leu Tyr Ile Ala Gly Arg Ile Ala Asp Lys Asn Ser

290 295 300cct cgc aaa aca gca ctc gta tgg ttc gtg ttc tct gca ttt tcc ctc 960Pro Arg Lys Thr Ala Leu Val Trp Phe Val Phe Ser Ala Phe Ser Leu305 310 315 320gcg ttg ctt gct gtc cgg atg cca ctg atc ggt ctg tat ggc atc gtg 1008Ala Leu Leu Ala Val Arg Met Pro Leu Ile Gly Leu Tyr Gly Ile Val

325 330 335ctg ctc acc ggc atc ttt gtg ttc agc tcc cag gta ctc atc tac gcc 1056Leu Leu Thr Gly Ile Phe Val Phe Ser Ser Gln Val Leu IleTyr Ala

340 345 350ttc gtt ggt gag aat cac cct gcc aag atg cgc gca acc gcc atg gga 1104Phe Val Gly Glu Asn His Pro Ala Lys Met Arg Ala Thr Ala Met Gly

355 360 365ttc tcc gca gga att ggt cgc ctc ggc gcc atc tct ggc ccg ttg ctt 1152Phe Ser Ala Gly Ile Gly Arg Leu Gly Ala Ile Ser Gly Pro Leu Leu

370375380 ggt ggt ctg ctt gtc agt gcc aac ctt gct tac cca tgg ggc ttc 1197Gly Gly Leu Leu Val Ser Ala Asn Leu Ala Tyr Pro Trp Gly Phe 385390395<210>416<211>399<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>416Thr Arg Ala Thr Lys Ser Val Gly Thr Val Leu Ala Leu Leu Trp Phe 151015 Ala Ile Val Leu Asp Gly Phe Asp Leu Val Val Leu Gly Ala Thr Ile

20 25 30Pro Ser Met Leu Glu Asp Pro Ala Trp Asp Leu Thr Ala Gly Gln Ala

35 40 45Thr Gln Ile Ser Thr Ile Gly Leu Val Gly Met Thr Ile Gly Ala Leu

50 55 60Thr Ile Gly Phe Leu Thr Asp Arg Leu Gly Arg Arg Arg Val Met Leu 65 70 75 80Phe Ser Val Ala Val Phe Ser Val Phe Thr Leu Leu Leu Ala Phe Thr

85 90 95Thr Asn Val Gln Leu Phe Ser Leu Trp Arg Phe Leu Ala Gly Val Gly

100 105 110Leu Gly Gly Ala Leu Pro Thr Ala Ile Ala Met Val Thr Glu Phe Arg

115 120 125Pro Gly Thr Lys Ala Gly Ser Ala Ser Thr Thr Leu Met Thr Gly Tyr

130 135 140His Val Gly Ala Val Ala Thr Ala Phe Leu Gly Leu Phe Leu Ile Asp145 150 155 160Gly Phe Gly Trp His Ser Met Phe Ile Ala Gly Ala Val Pro Gly Leu

165 170 175Ile Leu Leu Pro Leu Leu Tyr Phe Phe Leu Pro Glu Ser Pro Gln Tyr

180 185 190Leu Lys Ile Ser Gly Lys Leu Asp Glu Ala Gln Ala Val Ala Ala Ser

195 200 205Tyr Gly Leu Ser Leu Asp Asp Asp Leu Asp Arg Glu His Glu Glu Glu

210 215 220Leu Gly Glu Ser Ser Ser Leu Ser Ser Leu Phe Lys Pro Ser Phe Arg225 230 235 240Arg Asn Thr Leu Ala Ile Trp Gly Thr Ser Phe Met Gly Leu Leu Leu

245 250 255Val Tyr Gly Leu Asn Thr Trp Leu Pro Gln Ile Met Arg Gln Ala Asp

260 265 270Tyr Asp Met Gly Asn Ser Leu Gly Phe Leu Met Val Leu Asn Ile Gly

275 280 285Ala Val Ile Gly Leu Tyr Ile Ala Gly Arg Ile Ala Asp Lys Asn Ser

290 295 300Pro Arg Lys Thr Ala Leu Val Trp Phe Val Phe Ser Ala Phe Ser Leu305 310 315 320Ala Leu Leu Ala Val Arg Met Pro Leu Ile Gly Leu Tyr Gly Ile Val

325 330 335Leu Leu Thr Gly Ile Phe Val Phe Ser Ser Gln Val Leu Ile Tyr Ala

340 345 350Phe Val Gly Glu Asn His Pro Ala Lys Met Arg Ala Thr Ala Met Gly

355 360 365Phe Ser Ala Gly Ile Gly Arg Leu Gly Ala Ile Ser Gly Pro Leu Leu

370375380 Gly Gly Leu Leu Val Ser Ala Asn Leu Ala Tyr Pro Trp Gly Phe 385390395<210>417<211>1288<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).)

Met Ala Asp Asn Lys

1 5aat gcc gat gac agc cag cta gtc tca gcc agc act gga acc cct ggg 163Asn Ala Asp Asp Ser Gln Leu Val Ser Ala Ser Thr Gly Thr Pro Gly

10 15 20cct ggc gac att gca aaa gcc aat gcg cca tcc ctc aag caa gct gca 211Pro Gly Asp Ile Ala Lys Ala Asn Ala Pro Ser Leu Lys Gln Ala Ala

25 30 35gta acc gcc tct ggc cga agc gct ctg atg ggt gcc atc ttc ctc atg 259Val Thr Ala Ser Gly Arg Ser Ala Leu Met Gly Ala Ile Phe Leu Met

40 45 50gca act tct gcc atc ggc cca ggg ttc ctc acc caa acc gct gtc ttc 307Ala Thr Ser Ala Ile Gly Pro Gly Phe Leu Thr Gln Thr Ala Val Phe

55 60 65acc aac cag ctc ggc gca gct ttc gca ttt gcg atc ctg gtg tcg atc 355Thr Asn Gln Leu Gly Ala Ala Phe Ala Phe Ala Ile Leu Val Ser Ile 70 75 80 85ctc att gac atc gcg gtg cag ctg aat gtg tgg cgc atc atc ggc gtc 403Leu Ile Asp Ile Ala Val Gln Leu Asn Val Trp Arg Ile Ile Gly Val

90 95 100tct gaa atg cgc gcc caa gaa ctc ggc aac acg gtt atc cca ggt ttt 451Ser Glu Met Arg Ala Gln Glu Leu Gly Asn Thr Val Ile Pro Gly Phe

105 110 115ggt tgg gtg ctg gcc gta ctg gtc tgt att ggc ggc gta gta ttc aac 499Gly Trp Val Leu Ala Val Leu Val Cys Ile Gly Gly Val Val Phe Asn

120 125 130atc ggc aac atc gcc ggt ggt ggc ctt ggg ctt aac gcg ctg ctt ggc 547Ile Gly Asn Ile Ala Gly Gly Gly Leu Gly Leu Asn Ala Leu Leu Gly

135 140 145tgg gac gtc aaa gtt ggt ggc gtg atc acc gcg gcc atc gcg att gcg 595Trp Asp Val Lys Val Gly Gly Val Ile Thr Ala Ala Ile Ala Ile Ala150 155 160 165atc ttc ttg ttc aag cga ctt ggt gct gct ctg gac aaa ttc ctc gtg 643Ile Phe Leu Phe Lys Arg Leu Gly Ala Ala Leu Asp Lys Phe Leu Val

170 175 180gtc ctc ggc gtc gtg atg atc ctg ctc acc gtc tac gtg gct ttc gtc 691Val Leu Gly Val Val Met Ile Leu Leu Thr Val Tyr Val Ala Phe Val

185 190 195tcc caa cct cca gtt ggc tcg gcg ctg aag aat gca gta ctt cct gac 739Ser Gln Pro Pro Val Gly Ser Ala Leu Lys Asn Ala Val Leu Pro Asp

200 205 210acc atc gac tgg ctt gtc atc acc aca ctt gtg ggt gga acc gtc ggt 787Thr Ile Asp Trp Leu Val Ile Thr Thr Leu Val Gly Gly Thr Val Gly

215 220 225gga tac atc act tac gct ggc gca cac cgc atg ctg gac tcc gga cga 835Gly Tyr Ile Thr Tyr Ala Gly Ala His Arg Met Leu Asp Ser Gly Arg230 235 240 245acc ggc ccc aac aac gtc aaa gct gtt tcc aat tcc tct atc acc ggc 883Thr Gly Pro Asn Asn Val Lys Ala Val Ser Asn Ser Ser Ile Thr Gly

250 255 260atc ctg atc act ggc ctc atg cgc gtg gtg ctc ttc ctc gcg gtt ctc 931Ile Leu Ile Thr Gly Leu Met Arg Val Val Leu Phe Leu Ala Val Leu

265 270 275ggt gtt gtc gca ggt ggc gtc acc cta tcc acc acg ggc aac cca gcc 979Gly Val Val Ala Gly Gly Val Thr Leu Ser Thr Thr Gly Asn Pro Ala

280 285 290gcg gaa gca ttc cag cac gct gca ggc gat atc gga cta cgc atc ttc 1027Ala Glu Ala Phe Gln His Ala Ala Gly Asp Ile Gly Leu Arg Ile Phe

295 300 305ggc gcc gtg ctg tgg gca gcg tcc att tcc tca gtc atc ggc gcc agc 1075Gly Ala Val Leu Trp Ala Ala Ser Ile Ser Ser Val Ile Gly Ala Ser310 315 320 325tac acc tct gca acc ttc ctg gtg gaa aac aag cca gag aag aag cgt 1123Tyr Thr Ser Ala Thr Phe Leu Val Glu Asn Lys Pro Glu Lys Lys Arg

330 335 340ctg caa aac tgg gtg acc atc atc ttc atc ctg att tct tgc tcc gtg 1171Leu Gln Asn Trp Val Thr Ile Ile Phe Ile Leu Ile Ser Cys Ser Val

345 350 355ttc atc atg ctc ggc acg gca cca gca atc ctc ttg gtc ttc gcc gga 1219Phe Ile Met Leu Gly Thr Ala Pro Ala Ile Leu Leu Val Phe Ala Gly

360 365 370gca ttc aac ggt ttg gtc ctc ccc gta ggc ttt acc ctg atg atc tac 1267Ala Phe Asn Gly Leu Val Leu Pro Val Gly Phe Thr Leu Met Ile Tyr

375380385 gta gcg atc ttc cgc caa aaa 1288Val Ala Ile Phe Arg Gln Lys 390395<210>418<211>396<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>418Met Ala Asp Asn Lys Asn Ala Asp Asp Ser Gln Leu Val Ser Ala Ser 151015 Thr Gly Thr Pro Gly Pro Gly Asp Ile Ala Lys Ala Asn Ala Pro Ser

20 25 30Leu Lys Gln Ala Ala Val Thr Ala Ser Gly Arg Ser Ala Leu Met Gly

3540 45Ala Ile Phe Leu Met Ala Thr Ser Ala Ile Gly Pro Gly Phe Leu Thr

50 55 60Gln Thr Ala Val Phe Thr Asn Gln Leu Gly Ala Ala Phe Ala Phe Ala 65 70 75 80Ile Leu Val Ser Ile Leu Ile Asp Ile Ala Val Gln Leu Asn Val Trp

85 90 95Arg Ile Ile Gly Val Ser Glu Met Arg Ala Gln Glu Leu Gly Asn Thr

100 105 110Val Ile Pro Gly Phe Gly Trp Val Leu Ala Val Leu Val Cys Ile Gly

115 120 125Gly Val Val Phe Asn Ile Gly Asn Ile Ala Gly Gly Gly Leu Gly Leu

130 135 140Asn Ala Leu Leu Gly Trp Asp Val Lys Val Gly Gly Val Ile Thr Ala145 150 155 160Ala Ile Ala Ile Ala Ile Phe Leu Phe Lys Arg Leu Gly Ala Ala Leu

165 170 175Asp Lys Phe Leu Val Val Leu Gly Val Val Met Ile Leu Leu Thr Val

180 185 190Tyr Val Ala Phe Val Ser Gln Pro Pro Val Gly Ser Ala Leu Lys Asn

195 200 205Ala Val Leu Pro Asp Thr Ile Asp Trp Leu Val Ile Thr Thr Leu Val

210 215 220Gly Gly Thr Val Gly Gly Tyr Ile Thr Tyr Ala Gly Ala His Arg Met225 230 235 240Leu Asp Ser Gly Arg Thr Gly Pro Asn Asn Val Lys Ala Val Ser Asn

245 250 255Ser Ser Ile Thr Gly Ile Leu Ile Thr Gly Leu Met Arg Val Val Leu

260265 270Phe Leu Ala Val Leu Gly Val Val Ala Gly Gly Val Thr Leu Ser Thr

275 280 285Thr Gly Asn Pro Ala Ala Glu Ala Phe Gln His Ala Ala Gly Asp Ile

290 295 300Gly Leu Arg Ile Phe Gly Ala Val Leu Trp Ala Ala Ser Ile Ser Ser305 310 315 320Val Ile Gly Ala Ser Tyr Thr Ser Ala Thr Phe Leu Val Glu Asn Lys

325 330 335Pro Glu Lys Lys Arg Leu Gln Asn Trp Val Thr Ile Ile Phe Ile Leu

340 345 350Ile Ser Cys Ser Val Phe Ile Met Leu Gly Thr Ala Pro Ala Ile Leu

355 360 365Leu Val Phe Ala Gly Ala Phe Asn Gly Leu Val Leu Pro Val Gly Phe

370375380 Thr Leu Met Ile Tyr Val Ala Ile Phe Arg Gln Lys 385390395<210>419<211>487<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (487)<223>FRXA00590<400>419tacgctggcg cacaccgcat gctggactcc ggacgaaccg gccccaacac gtcaaagctg 60tttccaattc tctatcaccg gcatcctgat cactggcctc atg cgc gtg gtg ctc 115

Met Arg Val Val Leu

1 5ttc ctc gcg gtt ctc ggt gtt gtc gca ggt ggc gtc acc cta tcc acc 163Phe Leu Ala Val Leu Gly Val Val Ala Gly Gly Val Thr Leu Ser Thr

10 15 20acg ggc aac cca gcc gcg gaa gca ttc cag cac gct gca ggc gat atc 211Thr Gly Asn Pro Ala Ala Glu Ala Phe Gln His Ala Ala Gly Asp Ile

25 30 35gga cta cgc atc ttc ggc gcc gtg ctg tgg gca gcg tcc att tcc tca 259Gly Leu Arg Ile Phe Gly Ala Val Leu Trp Ala Ala Ser Ile Ser Ser

40 45 50gtc atc ggc gcc agc tac acc tct gca acc ttc ctg gtg gaa aac aag 307Val Ile Gly Ala Ser Tyr Thr Ser Ala Thr Phe Leu Val Glu Asn Lys

55 60 65cca gag aag aag cgt ctg caa aac tgg gtg acc atc atc ttc atc ctg 355Pro Glu Lys Lys Arg Leu Gln Asn Trp Val Thr Ile Ile Phe Ile Leu 70 75 80 85att tct tgc tcc gtg ttc atc atg ctc ggc acg gca cca gca atc ctc 403Ile Ser Cys Ser Val Phe Ile Met Leu Gly Thr Ala Pro Ala Ile Leu

90 95 100ttg gtc ttc gcc gga gca ttc aac ggt ttg gtc ctc ccc gta ggc ttt 451Leu Val Phe Ala Gly Ala Phe Asn Gly Leu Val Leu Pro Val Gly Phe

105 110 115acc ctg atg atc tac gta gcg atc ttc cgc caa aaa 487Thr Leu Met Ile Tyr Val Ala Ile Phe Arg Gln Lys

120125<210>420<211>129<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>420Met Arg Val Val Leu Phe Leu Ala Val Leu Gly Val Val Ala Gly Gly 151015 Val Thr Leu Ser Thr Thr Gly Asn Pro Ala Ala Glu Ala Phe Gln His

20 25 30Ala Ala Gly Asp Ile Gly Leu Arg Ile Phe Gly Ala Val Leu Trp Ala

35 40 45Ala Ser Ile Ser Ser Val Ile Gly Ala Ser Tyr Thr Ser Ala Thr Phe

50 55 60Leu Val Glu Asn Lys Pro Glu Lys Lys Arg Leu Gln Asn Trp Val Thr 65 70 75 80Ile Ile Phe Ile Leu Ile Ser Cys Ser Val Phe Ile Met Leu Gly Thr

85 90 95Ala Pro Ala Ile Leu Leu Val Phe Ala Gly Ala Phe Asn Gly Leu Val

100 105 110Leu Pro Val Gly Phe Thr Leu Met Ile Tyr Val Ala Ile Phe Arg Gln

115120125 Lys<210>421<211>490<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (490)<223>FRXA01538<400>421tctaaactca ctctcaactc accaagattg ttcaacaatc tgcgattggt gtgcaatcta 60ccccaatcat tttgaaagcc cccacgaaag gagcgcgaca atg gcc gac aac aaa 115

Met Ala Asp Asn Lys

1 5aat gcc gat gac agc cag cta gtc tca gcc agc act gga acc cct ggg 163Asn Ala Asp Asp Ser Gln Leu Val Ser Ala Ser Thr Gly Thr Pro Gly

10 15 20cct ggc gac att gca aaa gcc aat gcg cca tcc ctc aag caa gct gca 211Pro Gly Asp Ile Ala Lys Ala Asn Ala Pro Ser Leu Lys Gln Ala Ala

25 30 35gta acc gcc tct ggc cga agc gct ctg atg ggt gcc atc ttc ctc atg 259Val Thr Ala Ser Gly Arg Ser Ala Leu Met Gly Ala Ile Phe Leu Met

40 45 50gca act tct gcc atc ggc cca ggg ttc ctc acc caa acc gct gtc ttc 307Ala Thr Ser Ala Ile Gly Pro Gly Phe Leu Thr Gln Thr Ala Val Phe

55 60 65acc aac cag ctc ggc gca gct ttc gca ttt gcg atc ctg gtg tcg atc 355Thr Asn Gln Leu Gly Ala Ala Phe Ala Phe Ala Ile Leu Val Ser Ile 70 75 80 85ctc att gac atc gcg gtg cag ctg aat gtg tgg cgc atc atc ggc gtc 403Leu Ile Asp Ile Ala Val Gln Leu Asn Val Trp Arg Ile Ile Gly Val

90 95 100tct gaa atg cgc gcc caa gaa ctc ggc aac acg gtt atc cca ggt ttt 451Ser Glu Met Arg Ala Gln Glu Leu Gly Asn Thr Val Ile Pro Gly Phe

105 110 115ggt tgg gtg ctg gcc gta ctg gtc tgt att ggc ggc gta 490Gly Trp Val Leu Ala Val Leu Val Cys Ile Gly Gly Val

120125130<210>422<211>130<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>422Met Ala Asp Asn Lys Asn Ala Asp Asp Ser Gln Leu Val Ser Ala Ser 151015 Thr Gly Thr Pro Gly Pro Gly Asp Ile Ala Lys Ala Asn Ala Pro Ser

20 25 30Leu Lys Gln Ala Ala Val Thr Ala Ser Gly Arg Ser Ala Leu Met Gly

35 40 45Ala Ile Phe Leu Met Ala Thr Ser Ala Ile Gly Pro Gly Phe Leu Thr

50 55 60Gln Thr Ala Val Phe Thr Asn Gln Leu Gly Ala Ala Phe Ala Phe Ala 65 70 75 80Ile Leu Val Ser Ile Leu Ile Asp Ile Ala Val Gln Leu Asn Val Trp

85 90 95Arg Ile Ile Gly Val Ser Glu Met Arg Ala Gln Glu Leu Gly Asn Thr

100 105 110Val Ile Pro Gly Phe Gly Trp Val Leu Ala Val Leu Val Cys Ile Gly

115 120 125Gly Val

130<210>423<211>1401<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1378)<223>RXA01727<400>423agcttttggt ggtttcacca cctgcgctcgtcttaatttt gcgtgttcca gagagaccct 60tgaggagggg ctgcgccgta tcgccagcgt gttgtaaata atg agt aaa aag tct 115

Met Ser Lys Lys Ser

1 5gtc ctg att act tct ttg atg ctg ttt tcc atg ttc ttc gga gct gga 163Val Leu Ile Thr Ser Leu Met Leu Phe Ser Met Phe Phe Gly Ala Gly

10 15 20aac ctc atc ttc ccg ccg atg ctt gga ttg tcg gca gga acc aac tat 211Asn Leu Ile Phe Pro Pro Met Leu Gly Leu Ser Ala Gly Thr Asn Tyr

25 30 35cta cca gct atc tta gga ttt cta gca acg agt gtt ctg ctc ccg gtg 259Leu Pro Ala Ile Leu Gly Phe Leu Ala Thr Ser Val Leu Leu Pro Val

40 45 50ctg gcg att atc gcg gtg gtg ttg tcg gga gaa aat gtc aag gac atg 307Leu Ala Ile Ile Ala Val Val Leu Ser Gly Glu Asn Val Lys Asp Met

55 60 65gct tct cgt ggc ggt aag atc ttt ggc ctg gtg ttt cct att gct gcc 355Ala Ser Arg Gly Gly Lys Ile Phe Gly Leu Val Phe Pro Ile Ala Ala 70 75 80 85tat ttg tct atc ggc gcg ttt tac gcg ctg ccg agg act ggg gcg gtg 403Tyr Leu Ser Ile Gly Ala Phe Tyr Ala Leu Pro Arg Thr Gly Ala Val

90 95 100agc tat tcg acg gcg gtt ggc gtc gat aat gcg ctt tat tcg ggc ttg 451Ser Tyr Ser Thr Ala Val Gly Val Asp Asn Ala Leu Tyr Ser Gly Leu

105 110 115ttt aac ttt gtg ttt ttt gcg gtg gca ctg gcg ttg tcg tgg aat ccg 499Phe Asn Phe Val Phe Phe Ala Val Ala Leu Ala Leu Ser Trp Asn Pro

120 125 130aat ggc att gca gac aag ttg ggt aag tgg ctc acg cca gcg ttg ctc 547Asn Gly Ile Ala Asp Lys Leu Gly Lys Trp Leu Thr Pro Ala Leu Leu

135 140 145acg ttg att gtg gtg ctg gtg gtg ttg tcg gta gcc aag ttg gat ggc 595Thr Leu Ile Val Val Leu Val Val Leu Ser Val Ala Lys Leu Asp Gly150 155 160 165acg cca ggt gag cca agt agt gcg tat gcg cag cag cct gcg ggg gcg 643Thr Pro Gly Glu Pro Ser Ser Ala Tyr Ala Gln Gln Pro Ala Gly Ala

170 175 180ggt ttg ctt gag ggc tac atg acg atg gat gcg att gct gcg ttg gcg 691Gly Leu Leu Glu Gly Tyr Met Thr Met Asp Ala Ile Ala Ala Leu Ala

185 190 195ttt ggc atc gtg gtg att tct gcg ttc aag tac caa aag gtt aac aag 739Phe Gly Ile Val Val Ile Ser Ala Phe Lys Tyr Gln Lys Val Asn Lys

200 205 210gtc cgc acg gca act gtc gtg tcg gcg ttc att gcc gga att ttg ttg 787Val Arg Thr Ala Thr Val Val Ser Ala Phe Ile Ala Gly Ile Leu Leu

215 220 225gcg ctg gtt tat ctt ggt ttg ggc tca atc ggt caa gta gta aac ggt 835Ala Leu Val Tyr Leu Gly Leu Gly Ser Ile Gly Gln Val Val Asn Gly230 235 240 245gag ttc gct gat ggc acc gca att ttg aac tac gct gca ctg tcc acg 883Glu Phe Ala Asp Gly Thr Ala Ile Leu Asn Tyr Ala Ala Leu Ser Thr

250 255 260atg ggt cag gcc ggt cgc atc atg ttc gtg gct att ttg atc ctt gca 931Met Gly Gln Ala Gly Arg Ile Met Phe Val Ala Ile Leu Ile Leu Ala

265 270 275tgt atg acc acc gca gtt ggt ctg atc agt gcg acg tct gag ttt ttc 979Cys Met Thr Thr Ala Val Gly Leu Ile Ser Ala Thr Ser Glu Phe Phe

280 285 290aat tcg ctg ctg cca ggt gtc aag tac cac gtc tgg gcc act gtt ttc 1027Asn Ser Leu Leu Pro Gly Val Lys Tyr His Val Trp Ala Thr Val Phe

295 300 305gcg ctg att tcc ttt ggc gtt gcc acc atg ggt ttg gat acg gtg ttg 1075Ala Leu Ile Ser Phe Gly Val Ala Thr Met Gly Leu Asp Thr Val Leu310 315 320 325gcc gtt gcg gct cca gtg att agt ttc att tac cca tcg gcc atc acc 1123Ala Val Ala Ala Pro Val Ile Ser Phe Ile Tyr Pro Ser Ala Ile Thr

330 335 340ttg gtg ttc ttg tcg ctc atc gag ccc ctg ctg ttc cgt ctc aag tgg 1171Leu Val Phe Leu Ser Leu Ile Glu Pro Leu Leu Phe Arg Leu Lys Trp

345 350 355acc tac cta ttc ggc att tgg act gca gtt gtg tgg gcg ctg ttc atg 1219Thr Tyr Leu Phe Gly Ile Trp Thr Ala Val Val Trp Ala Leu Phe Met

360 365 370tct atc cct gcg ctg aat cca ttc atc gaa tgg gcg ccg ctg cac agc 1267Ser Ile Pro Ala Leu Asn Pro Phe Ile Glu Trp Ala Pro Leu His Ser

375 380 385atg tct ttg ggt tgg gtt gtc cca gtt ctc gtg gcc tct gcc atc ggt 1315Met Ser Leu Gly Trp Val Val Pro Val Leu Val Ala Ser Ala Ile Gly390 395 400 405ttg gct att gat tgg aac aag aaa ggt gcc cag tct gtt gca aag aag 1363Leu Ala Ile Asp Trp Asn Lys Lys Gly Ala Gln Ser Val Ala Lys Lys

410 415 420gaa tcc att tcc gtc taatcgctaa ttgcgaggag tct 1401Glu Ser Ile Ser Val

425<210>424<211>426<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>424Met Ser Lys Lys Ser Val Leu Ile Thr Ser Leu Met Leu Phe Ser Met 151015 Phe Phe Gly Ala Gly Asn Leu Ile Phe Pro Pro Met Leu Gly Leu Ser

20 25 30Ala Gly Thr Asn Tyr Leu Pro Ala Ile Leu Gly Phe Leu Ala Thr Ser

35 40 45Val Leu Leu Pro Val Leu Ala Ile Ile Ala Val Val Leu Ser Gly Glu

50 55 60Asn Val Lys Asp Met Ala Ser Arg Gly Gly Lys Ile Phe Gly Leu Val 65 70 75 80Phe Pro Ile Ala Ala Tyr Leu Ser Ile Gly Ala Phe Tyr Ala Leu Pro

85 90 95Arg Thr Gly Ala Val Ser Tyr Ser Thr Ala Val Gly Val Asp Asn Ala

100 105 110Leu Tyr Ser Gly Leu Phe Asn Phe Val Phe Phe Ala Val Ala Leu Ala

115 120 125Leu Ser Trp Asn Pro Asn Gly Ile Ala Asp Lys Leu Gly Lys Trp Leu

130 135 140Thr Pro Ala Leu Leu Thr Leu Ile Val Val Leu Val Val Leu Ser Val145 150 155 160Ala Lys Leu Asp Gly Thr Pro Gly Glu Pro Ser Ser Ala Tyr Ala Gln

165 170 175Gln Pro Ala Gly Ala Gly Leu Leu Glu Gly Tyr Met Thr Met Asp Ala

180 185 190Ile Ala Ala Leu Ala Phe Gly Ile Val Val Ile Ser Ala Phe Lys Tyr

195 200 205Gln Lys Val Asn Lys Val Arg Thr Ala Thr Val Val Ser Ala Phe Ile

210 215 220Ala Gly Ile Leu Leu Ala Leu Val Tyr Leu Gly Leu Gly Ser Ile Gly225230 235 240Gln Val Val Asn Gly Glu Phe Ala Asp Gly Thr Ala Ile Leu Asn Tyr

245 250 255Ala Ala Leu Ser Thr Met Gly Gln Ala Gly Arg Ile Met Phe Val Ala

260 265 270Ile Leu Ile Leu Ala Cys Met Thr Thr Ala Val Gly Leu Ile Ser Ala

275 280 285Thr Ser Glu Phe Phe Asn Ser Leu Leu Pro Gly Val Lys Tyr His Val

290 295 300Trp Ala Thr Val Phe Ala Leu Ile Ser Phe Gly Val Ala Thr Met Gly305 310 315 320Leu Asp Thr Val Leu Ala Val Ala Ala Pro Val Ile Ser Phe Ile Tyr

325 330 335Pro Ser Ala Ile Thr Leu Val Phe Leu Ser Leu Ile Glu Pro Leu Leu

340 345 350Phe Arg Leu Lys Trp Thr Tyr Leu Phe Gly Ile Trp Thr Ala Val Val

355 360 365Trp Ala Leu Phe Met Ser Ile Pro Ala Leu Asn Pro Phe Ile Glu Trp

370 375 380 Ala Pro Leu His Ser Met Ser Leu Gly Trp Val Val Pro Val Leu Val385 390 395 400Ala Ser Ala Ile Gly Leu Ala Ile Asp Trp Asn Lys Lys Gly Ala Gln

405 410 415Ser Val Ala Lys Lys Glu Ser Ile Ser Val

420425<210>425<211>1461<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1438)<223>RXA00623<400>425tttaagcttc gtcggcaacg atcacaccac gttaaatttc gaccatcaat gacggtggcc 60gttttttggc gaatccccaa aaaggtcgaa gaggaagttc atg gat tca aac aca 115

Met Asp Ser Asn Thr

1 5gaa tct tca agt gtt gag gtc aaa aac gaa cac att aaa gtt caa aag 163Glu Ser Ser Ser Val Glu Val Lys Asn Glu His Ile Lys Val Gln Lys

10 15 20ccg ccg aag aag gac cgc act cac tgg ctc tac att gcg gtc att atc 211Pro Pro Lys Lys Asp Arg Thr His Trp Leu Tyr Ile Ala Val Ile Ile

25 30 35gca ttg att ggc ggt att acc cta ggc ctg att tca ccg gag ttg ggc 259Ala Leu Ile Gly Gly Ile Thr Leu Gly Leu Ile Ser Pro Glu Leu Gly

40 45 50aaa gaa ttc aag att ttg ggc acc atg ttt gtg tcc ttg atc aag atg 307Lys Glu Phe Lys Ile Leu Gly Thr Met Phe Val Ser Leu Ile Lys Met

55 60 65att atc gct cca gtt att ttc tgc acc atc gtc atc gga atc ggt tca 355Ile Ile Ala Pro Val Ile Phe Cys Thr Ile Val Ile Gly Ile Gly Ser 70 75 80 85gtc aag gca gcg gca aca gtc gga cgc gct ggt ggc atc gcc ctt gcg 403Val Lys Ala Ala Ala Thr Val Gly Arg Ala Gly Gly Ile Ala Leu Ala

90 95 100tac ttc atc acg atg tcc aca ttc gca ctc gca gtt ggc ctg cta gtc 451Tyr Phe Ile Thr Met Ser Thr Phe Ala Leu Ala Val Gly Leu Leu Val

105 110 115ggt aac ttc atc cag cca ggt agc gga ctg aac atc tca gtt gat gaa 499Gly Asn Phe Ile Gln Pro Gly Ser Gly Leu Asn Ile Ser Val Asp Glu

120 125 130gaa tct tca ttc gca tcc aca gag agc agc cct gaa gga ctc ttg gga 547Glu Ser Ser PheAla Ser Thr Glu Ser Ser Pro Glu Gly Leu Leu Gly

135 140 145ttc atc cac tcg atc atc cct gaa acg ttc ttc tct gca ttt act gat 595Phe Ile His Ser Ile Ile Pro Glu Thr Phe Phe Ser Ala Phe Thr Asp150 155 160 165ggt tcg gtg ctg cag gta ctg ttc atc gcc atc ctc gtg ggc ttt gca 643Gly Ser Val Leu Gln Val Leu Phe Ile Ala Ile Leu Val Gly Phe Ala

170 175 180gct cag tcg atg ggt gaa aag gga cag ccc atc ctt gat ttc gta tcc 691Ala Gln Ser Met Gly Glu Lys Gly Gln Pro Ile Leu Asp Phe Val Ser

185 190 195cat ctg cag aag ctc atc ttc aag att ttg aac tgg att ctg tgg ctc 739His Leu Gln Lys Leu Ile Phe Lys Ile Leu Asn Trp Ile Leu Trp Leu

200 205 210gcc cca gtc ggt gca ttc ggt gca atg gcc ggc gtc gtt ggc gaa aca 787Ala Pro Val Gly Ala Phe Gly Ala Met Ala Gly Val Val Gly Glu Thr

215 220 225ggc ttt gat gcc gtt gtt cag ctc ggt att ttg atc ctc gcc ttt tac 835Gly Phe Asp Ala Val Val Gln Leu Gly Ile Leu Ile Leu Ala Phe Tyr230 235 240 245gtc acc tgc gtg atc ttc atc ttt ggc gtg ctg ggc gcc gta ctg aag 883Val Thr Cys Val Ile Phe Ile Phe Gly Val Leu Gly Ala Val Leu Lys

250 255 260gtg ttc acc ggc gtg aat atc ttc aag ctg gtc aag tac ctt gcc aag 931Val Phe Thr Gly Val Asn Ile Phe Lys Leu Val Lys Tyr Leu Ala Lys

265 270 275gaa ttc ctg ctg atc ttt gct acc tca tcc tct gaa tct gcc ttg cca 979Glu Phe Leu Leu Ile Phe Ala Thr Ser Ser Ser Glu Ser Ala Leu Pro

280 285 290aac ctc atg cgc aag atg gaa cac atc ggt gtg gct aaa cca acc gtc 1027Asn Leu Met Arg Lys Met Glu His Ile Gly Val Ala Lys Pro Thr Val

295 300 305gga atc gtg gtc cca acc ggc tat tcc ttc aac ttg gac ggc acc gca 1075Gly Ile Val Val Pro Thr Gly Tyr Ser Phe Asn Leu Asp Gly Thr Ala310 315 320 325att tac ctc acc atg gca tct atc ttc att gcc gac gcg atg aat atg 1123Ile Tyr Leu Thr Met Ala Ser Ile Phe Ile Ala Asp Ala Met Asn Met

330 335 340ccg atg agc ctc ggc gag cag gtc ggt ctg ctt gtc ttc atg atc atc 1171Pro Met Ser Leu Gly Glu Gln Val Gly Leu Leu Val Phe Met Ile Ile

345 350 355gca tcc aag ggc gct gct ggt gtc tcg ggt gcc ggt att gca acg ttg 1219Ala Ser Lys Gly Ala Ala Gly Val Ser Gly Ala Gly Ile Ala Thr Leu

360 365 370gct gcc gga ttg tct tca cac cgc cca gaa ctt ctg cac ggc gtt gac 1267Ala Ala Gly Leu Ser Ser His Arg Pro Glu Leu Leu His Gly Val Asp

375 380 385gtg att gtg ggc atc gat aaa ttc atg tct gaa gcc cgc gca cta acc 1315Val Ile Val Gly Ile Asp Lys Phe Met Ser Glu Ala Arg Ala Leu Thr390 395 400 405aac ttc gcc gga aac tcc gtg gca aca ctg ctg gtc ggc aag tgg act 1363Asn Phe Ala Gly Asn Ser Val Ala Thr Leu Leu Val Gly Lys Trp Thr

410 415 420ggc acc gtg gac atg aac caa gtc cat gac gtt ttg aat gga aaa tct 1411Gly Thr Val Asp Met Asn Gln Val His Asp Val Leu Asn Gly Lys Ser

425 430 435cca ttt gtg gag tta gaa gaa gac cac tagttttcaa caggacgaca 1458Pro Phe Val Glu Leu Glu Glu Asp His

440445 acg1461<210>426<211>446<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>426Met Asp Ser Asn Thr Glu Ser Ser Ser Val Glu Val Lys Asn Glu His 151015 Ile Lys Val Gln Lys Pro Pro Lys Lys Asp Arg Thr His Trp Leu Tyr

20 25 30Ile Ala Val Ile Ile Ala Leu Ile Gly Gly Ile Thr Leu Gly Leu Ile

35 40 45Ser Pro Glu Leu Gly Lys Glu Phe Lys Ile Leu Gly Thr Met Phe Val

50 55 60Ser Leu Ile Lys Met Ile Ile Ala Pro Val Ile Phe Cys Thr Ile Val 65 70 75 80Ile Gly Ile Gly Ser Val Lys Ala Ala Ala Thr Val Gly Arg Ala Gly

85 90 95Gly Ile Ala Leu Ala Tyr Phe Ile Thr Met Ser Thr Phe Ala Leu Ala

100 105 110Val Gly Leu Leu Val Gly Asn Phe Ile Gln Pro Gly Ser Gly Leu Asn

115 120 125Ile Ser Val Asp Glu Glu Ser Ser Phe Ala Ser Thr Glu Ser Ser Pro

130 135 140Glu Gly Leu Leu Gly Phe Ile His Ser Ile Ile Pro Glu Thr Phe Phe145 150 155 160Ser Ala Phe Thr Asp Gly Ser Val Leu Gln Val Leu Phe Ile Ala Ile

165 170 175Leu Val Gly Phe Ala Ala Gln Ser Met Gly Glu Lys Gly Gln Pro Ile

180 185 190Leu Asp Phe Val Ser His Leu Gln Lys Leu Ile Phe Lys Ile Leu Asn

195 200 205Trp Ile Leu Trp Leu Ala Pro Val Gly AlaPhe Gly Ala Met Ala Gly

210 215 220Val Val Gly Glu Thr Gly Phe Asp Ala Val Val Gln Leu Gly Ile Leu225 230 235 240Ile Leu Ala Phe Tyr Val Thr Cys Val Ile Phe Ile Phe Gly Val Leu

245 250 255Gly Ala Val Leu Lys Val Phe Thr Gly Val Asn Ile Phe Lys Leu Val

260 265 270Lys Tyr Leu Ala Lys Glu Phe Leu Leu Ile Phe Ala Thr Ser Ser Ser

275 280 285Glu Ser Ala Leu Pro Asn Leu Met Arg Lys Met Glu His Ile Gly Val

290 295 300Ala Lys Pro Thr Val Gly Ile Val Val Pro Thr Gly Tyr Ser Phe Asn305 310 315 320Leu Asp Gly Thr Ala Ile Tyr Leu Thr Met Ala Ser Ile Phe Ile Ala

325 330 335Asp Ala Met Asn Met Pro Met Ser Leu Gly Glu Gln Val Gly Leu Leu

340 345 350Val Phe Met Ile Ile Ala Ser Lys Gly Ala Ala Gly Val Ser Gly Ala

355 360 365Gly Ile Ala Thr Leu Ala Ala Gly Leu Ser Ser His Arg Pro Glu Leu

370 375 380Leu His Gly Val Asp Val Ile Val Gly Ile Asp Lys Phe Met Ser Glu385 390 395 400Ala Arg Ala Leu Thr Asn Phe Ala Gly Asn Ser Val Ala Thr Leu Leu

405 410 415Val Gly Lys Trp Thr Gly Thr Val Asp Met Asn Gln Val His Asp Val

420 425 430Leu Asn Gly Lys Ser Pro Phe Val Glu Leu Glu Glu Asp His

435440445<210>427<211>620<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(55) } (597)<223>RXA01584<400>427ccaccccctt ccccgctacg cgccataccg gcttgggcgg gcatcggatc acta gtg 57

Val

1gtg ttt ttg ggc gca ctt crc ggc gcc gta atc atg ggc ggg ttt tat 105Val Phe Leu Gly Ala Leu Leu Gly Ala Val Ile Met Gly Gly Phe Tyr

5 10 15cca gca ttc att caa gcc gga tcc aca gtg ttc ggc ggc ggc cac gtg 153Pro Ala Phe Ile Gln Ala Gly Ser Thr Val Phe Gly Gly Gly His Val

20 25 30gtt ttg cca ctg ctg gaa aag ctc gtt gtt gcg ccc ggt ttt att aaa 201Val Leu Pro Leu Leu Glu Lys Leu Val Val Ala Pro Gly Phe Ile Lys

35 40 45gaa acc gac ttc cta tcc ggc tac tcc gca gcg cag gca gtg cct ggc 249Glu Thr Asp Phe Leu Ser Gly Tyr Ser Ala Ala Gln Ala Val Pro Gly 50 55 60 65ccc atg ttc agc ttc gcc agc tac ctc ggc gca atc tac ggt ggc atc 297Pro Met Phe Ser Phe Ala Ser Tyr Leu Gly Ala Ile Tyr Gly Gly Ile

70 75 80ggt ggt gca gtg ctg gcc agc ctg gcg atc ttc ttc ccc gcc gca ctc 345Gly Gly Ala Val Leu Ala Ser Leu Ala Ile Phe Phe Pro Ala Ala Leu

85 90 95ttg agc atc agc gga atg tac ttt tgg gga cgc tgg cga aaa gca ccg 393Leu Ser Ile Ser Gly Met Tyr Phe Trp Gly Arg Trp Arg Lys Ala Pro

100 105 110cgc atc caa gca gca gtc acc ggc atc aac gcc ggt gtg gtg ggg ctt 441Arg Ile Gln Ala Ala Val Thr Gly Ile Asn Ala Gly Val Val Gly Leu

115 120 125ttg ggc gca gcg ctc tac gat ccc gta ttc acc cac ggc atc acc agc 489Leu Gly Ala Ala Leu Tyr Asp Pro Val Phe Thr His Gly Ile Thr Ser130 135 140 145gtt tcc gca tta gct atc gca acg gtg tgt tgg ctg ggg cta gcc cac 537Val Ser Ala Leu Ala Ile Ala Thr Val Cys Trp Leu Gly Leu Ala His

150 155 160tgg aaa att ccg ccg tgg gcc atc gcc gcg ggt gcg gcc ctt gca ggc 585Trp Lys Ile Pro Pro Trp Ala Ile Ala Ala Gly Ala Ala Leu Ala Gly

165 170 175tgg gtc ttg ctt tagaaaacgc tcagacccaa acc 620Trp Val Leu Leu

180<210>428<211>181<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>428Val Val Phe Leu Gly Ala Leu Leu Gly Ala Val Ile Met Gly Gly Phe 151015 Tyr Pro Ala Phe Ile Gln Ala Gly Ser Thr Val Phe Gly Gly Gly His

20 25 30Val Val Leu Pro Leu Leu Glu Lys Leu Val Val Ala Pro Gly Phe Ile

35 40 45Lys Glu Thr Asp Phe Leu Ser Gly Tyr Ser Ala Ala Gln Ala Val Pro

50 55 60Gly Pro Met Phe Ser Phe Ala Ser Tyr Leu Gly Ala Ile Tyr Gly Gly 65 70 75 80Ile Gly Gly Ala Val Leu Ala Ser Leu Ala Ile Phe Phe Pro Ala Ala

85 90 95Leu Leu Ser Ile Ser Gly Met Tyr Phe Trp Gly Arg Trp Arg Lys Ala

100 105 110Pro Arg Ile Gln Ala Ala Val Thr Gly Ile Asn Ala Gly Val Val Gly

115 120 125Leu Leu Gly Ala Ala Leu Tyr Asp Pro Val Phe Thr His Gly Ile Thr

130 135 140Ser Val Ser Ala Leu Ala Ile Ala Thr Val Cys Trp Leu Gly Leu Ala145 150 155 160His Trp Lys Ile Pro Pro Trp Ala Ile Ala Ala Gly Ala Ala Leu Ala

165 170 175Gly Trp Val Leu Leu

180<210>429<211>813<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (790)<223>RXA00852<400>429agatcaccgt catggtcata atcgccgctg gagttcatgc agcattccct gacatccgta 60agaaatagtt ccaacccact tttcctcaga attgcagttc atg ccc gag atc att 115

Met Pro Glu Ile Ile

1 5 ttt gac aac act gaa gta cgc tac gat gac tcg crc att tta gag ccc 163Phe Asp Asn Thr Glu Val Arg Tyr Asp Asp Ser Leu Ile Leu Glu Pro

10 15 20cta tcg tta aaa ctg aca gaa caa cgc att ggc atc atc ggg gct aac 211Leu Ser Leu Lys Leu Thr Glu Gln Arg Ile Gly Ile Ile Gly Ala Asn

25 30 35ggc ggt gga aaa tcc acg ctc atc aga atg atc aat ggt ctc ggc gaa 259Gly Gly Gly Lys Ser Thr Leu Ile Arg Met Ile Asn Gly Leu Gly Glu

40 45 50cca acc aca ggg cgt gtt cta gtt gat ggc ctt gac gtc tcg cat tcc 307Pro Thr Thr Gly Arg Val Leu Val Asp Gly Leu Asp Val Ser His Ser

55 60 65gga cgg gaa gtt cgc aag aag gttgga ttt gtc ttc tct gac gct gaa 355Gly Arg Glu Val Arg Lys Lys Val Gly Phe Val Phe Ser Asp Ala Glu 70 75 80 85aac cag atc gtg atg cca act gtg cgt gag gat att gcc ttc tcg ctt 403Asn Gln Ile Val Met Pro Thr Val Arg Glu Asp Ile Ala Phe Ser Leu

90 95 100cgc cgg cac aaa atg cca cgc gct gaa aag gcg caa cgt gtc gac gag 451Arg Arg His Lys Met Pro Arg Ala Glu Lys Ala Gln Arg Val Asp Glu

105 110 115atg atg gcg cga ttc aac ttg agc gag cat gca gat caa tca ccg cac 499Met Met Ala Arg Phe Asn Leu Ser Glu His Ala Asp Gln Ser Pro His

120 125 130acc cta tcc ggt ggt caa aag cag ttg tta gcg ctg gct gca gta ctg 547Thr Leu Ser Gly Gly Gln Lys Gln Leu Leu Ala Leu Ala Ala Val Leu

135 140 145att ttg gag cca gaa gtg atc atc gct gat gag ccc act acc ctg ctg 595Ile Leu Glu Pro Glu Val Ile Ile Ala Asp Glu Pro Thr Thr Leu Leu150 155 160 165gat ctg cgc aat agg ctg atg atc aaa gac gtg ttc aat aaa ctc gag 643Asp Leu Arg Asn Arg Leu Met Ile Lys Asp Val Phe Asn Lys Leu Glu

170 175 180cag caa tta atc gtt gtc agc cat gat tta gat ttc ctc agc gat ttt 691Gln Gln Leu Ile Val Val Ser His Asp Leu Asp Phe Leu Ser Asp Phe

185 190 195gag cgg gtc att tgc atc aat gat cat aaa atc gct gct gat ggc cct 739Glu Arg Val Ile Cys Ile Asn Asp His Lys Ile Ala Ala Asp Gly Pro

200 205 210ccg caa aag tcc att gac ctg tac gta tcg ctt atg gcg gaa cct gcg 787Pro Gln Lys Ser Ile Asp Leu Tyr Val Ser Leu Met Ala Glu Pro Ala

215220225 aaa tgaacagtat tcctttaggt ttt 813Lys230<210>430<211>230<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>430Met Pro Glu Ile Ile Phe Asp Asn Thr Glu Val Arg Tyr Asp Asp Ser 151015 Leu Ile Leu Glu Pro Leu Ser Leu Lys Leu Thr Glu Gln Arg Ile Gly

20 25 30Ile Ile Gly Ala Asn Gly Gly Gly Lys Ser Thr Leu Ile Arg Met Ile

35 40 45Asn Gly Leu Gly Glu Pro Thr Thr Gly Arg Val Leu Val Asp Gly Leu

50 55 60Asp Val Ser His Ser Gly Arg Glu Val Arg Lys Lys Val Gly Phe Val 65 70 75 80Phe Ser Asp Ala Glu Asn Gln Ile Val Met Pro Thr Val Arg Glu Asp

85 90 95Ile Ala Phe Ser Leu Arg Arg His Lys Met Pro Arg Ala Glu Lys Ala

100 105 110Gln Arg Val Asp Glu Met Met Ala Arg Phe Asn Leu Ser Glu His Ala

115 120 125Asp Gln Ser Pro His Thr Leu Ser Gly Gly Gln Lys Gln Leu Leu Ala

130 135 140Leu Ala Ala Val Leu Ile Leu Glu Pro Glu Val Ile Ile Ala Asp Glu145 150 155 160Pro Thr Thr Leu Leu Asp Leu Arg Asn Arg Leu Met Ile Lys Asp Val

165 170 175Phe Asn Lys Leu Glu Gln Gln Leu Ile Val Val Ser His Asp Leu Asp

180 185 190Phe Leu Ser Asp Phe Glu Arg Val Ile Cys Ile Asn Asp His Lys Ile

195 200 205Ala AlaAsp Gly Pro Pro Gln Lys Ser Ile Asp Leu Tyr Val Ser Leu

210215220 Met Ala Glu Pro Ala Lys 225230<210>431<211>1269<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1246)<223>RXA00690<400>431atggatcatt ggactcacac tggctgtcat ttccttggtt tcagcgtctg ctgtggcggc 60gtgggcgatt cgtcgttcag aggtccaggg ttaaagcttc gtg aaa tgg att gag 115

Val Lys Trp Ile Glu

1 5cga tat gtg ctg tcc cgg cgg atg gtt cat ccc tgg gcg tgg tgg gtg 163Arg Tyr Val Leu Ser Arg Arg Met Val His Pro Trp Ala Trp Trp Val

10 15 20tgg gcg ttg ggt att gct ggt tgt gcc agc atg acc aac aat cct tat 211Trp Ala Leu Gly Ile Ala Gly Cys Ala Ser Met Thr Asn Asn Pro Tyr

25 30 35att ttg gcg ctc act ttt gcc acg ttg tgt ttt gtg gtg ttt aac cgt 259Ile Leu Ala Leu Thr Phe Ala Thr Leu Cys Phe Val Val Phe Asn Arg

40 45 50cgt ggg tca tcg ccg tgg tcg cgt gct ttc ccg atc tat ttg atg atc 307Arg Gly Ser Ser Pro Trp Ser Arg Ala Phe Pro Ile Tyr Leu Met Ile

55 60 65gcg ggt tgg ctc gtg gtg tac cgg ttg gtc atg cac att gtg gtg gga 355Ala Gly Trp Leu Val Val Tyr Arg Leu Val Met His Ile Val Val Gly 70 75 80 85gca aaa att ggc acc att gaa ctg ttt cgg atc ccg ccg gtg cag ttg 403Ala Lys Ile Gly Thr Ile Glu Leu Phe Arg Ile Pro Pro Val Gln Leu

90 95 100ccg gaa tgg gct gcg ggt atc cac gtg ttt ggc acg gtg tat ctc gag 451Pro Glu Trp Ala Ala Gly Ile His Val Phe Gly Thr Val Tyr Leu Glu

105 110 115ggt ctg atc atc gcg acg acg caa ggc tta acg ctt gga acg atg atc 499Gly Leu Ile Ile Ala Thr Thr Gln Gly Leu Thr Leu Gly Thr Met Ile

120 125 130gtg gcg gtg ggt gct gcg aac tct ttg gcg gat ccc aag aag ctg ctc 547Val Ala Val Gly Ala Ala Asn Ser Leu Ala Asp Pro Lys Lys Leu Leu

135 140 145aaa tcg ttg cct ggc gca ttg ggc gaa ctg gga act gcg gtg gtc atc 595Lys Ser Leu Pro Gly Ala Leu Gly Glu Leu Gly Thr Ala Val Val Ile150 155 160 165ggt att tcc att gca cct cag atg gct gag tcg gcg ttc cgc att aat 643Gly Ile Ser Ile Ala Pro Gln Met Ala Glu Ser Ala Phe Arg Ile Asn

170 175 180cgt gca cga acc ttg cgt ggt gat gat gcc aaa ggt gtt cgt ggt ttc 691Arg Ala Arg Thr Leu Arg Gly Asp Asp Ala Lys Gly Val Arg Gly Phe

185 190 195gcg cgg att ttg atg ccg gtt ttc cag gac act ttg gat agg tct ttg 739Ala Arg Ile Leu Met Pro Val Phe Gln Asp Thr Leu Asp Arg Ser Leu

200 205 210gcc ctg gct aat tcc atg gat gcc cgt ggt tat ggc agg cag gct cat 787Ala Leu Ala Asn Ser Met Asp Ala Arg Gly Tyr Gly Arg Gln Ala His

215 220 225gta tcc aaa ttc caa cag cgt gtg acc tct att ttt ggt gca ttc gga 835Val Ser Lys Phe Gln Gln Arg Val Thr Ser Ile Phe Gly Ala Phe Gly230 235 240 245ata ctc ggc gtg acc gtt ggt ctg ttt gtg gtc tta gat gca tca tca 883Ile Leu Gly Val Thr Val Gly Leu Phe Val Val Leu Asp Ala Ser Ser

250 255 260ccg atg ttc gtt gcc gtt ccg gtg ttt att acc ggc gtg ggc ttc ttg 931Pro Met Phe Val Ala Val Pro Val Phe Ile Thr Gly Val Gly Phe Leu

265 270 275atc att tcg ttg gtc gtt gct tca cat aga aaa aca tcc acc act ttt 979Ile Ile Ser Leu Val Val Ala Ser His Arg Lys Thr Ser Thr Thr Phe

280 285 290gat cag ttg cct tgg ggt gct gcg gaa tgg ctt gtg tgc atc aca ggt 1027Asp Gln Leu Pro Trp Gly Ala Ala Glu Trp Leu Val Cys Ile Thr Gly

295 300 305gtg att ccg ctg ctc atg gct gcg ctg aca cga tac ctt gat cca ggt 1075Val Ile Pro Leu Leu Met Ala Ala Leu Thr Arg Tyr Leu Asp Pro Gly310 315 320 325tcc atg atc acc acc tgg gtt cct ttg cat atg cca gac acc gtt ccg 1123Ser Met Ile Thr Thr Trp Val Pro Leu His Met Pro Asp Thr Val Pro

330 335 340ttg ctc gtt gtg gca gga ctt gtt gtg gcg acg atg cca gga ttc ttg 1171Leu Leu Val Val Ala Gly Leu Val Val Ala Thr Met Pro Gly Phe Leu

345 350 355acg ccc cgc ttg ccg aag aac aaa gtg agg gtc aag cgt cga aaa gca 1219Thr Pro Arg Leu Pro Lys Asn Lys Val Arg Val Lys Arg Arg Lys Ala

360 365 370ata aat agc cca gaa agg gcc gaa gtt taatgagtgc tccttttagc 1266Ile Asn Ser Pro Glu Arg Ala Glu Val

375380 gcg1269<210>432<211>382<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>432Val Lys Trp Ile Glu Arg Tyr Val Leu Ser Arg Arg Met Val His Pro 151015 Trp Ala Trp Trp Val Trp Ala Leu Gly Ile Ala Gly Cys Ala Ser Met

20 25 30Thr Asn Asn Pro TyrIle Leu Ala Leu Thr Phe Ala Thr Leu Cys Phe

35 40 45Val Val Phe Asn Arg Arg Gly Ser Ser Pro Trp Ser Arg Ala Phe Pro

50 55 60Ile Tyr Leu Met Ile Ala Gly Trp Leu Val Val Tyr Arg Leu Val Met 65 70 75 80His Ile Val Val Gly Ala Lys Ile Gly Thr Ile Glu Leu Phe Arg IIe

85 90 95Pro Pro Val Gln Leu Pro Glu Trp Ala Ala Gly Ile His Val Phe Gly

100 105 110Thr Val Tyr Leu Glu Gly Leu Ile Ile Ala Thr Thr Gln Gly Leu Thr

115 120 125Leu Gly Thr Met Ile Val Ala Val Gly Ala Ala Asn Ser Leu Ala Asp

130 135 140Pro Lys Lys Leu Leu Lys Ser Leu Pro Gly Ala Leu Gly Glu Leu Gly145 150 155 160Thr Ala Val Val Ile Gly Ile Ser Ile Ala Pro Gln Met Ala Glu Ser

165 170 175Ala Phe Arg Ile Asn Arg Ala Arg Thr Leu Arg Gly Asp Asp Ala Lys

180 185 190Gly Val Arg Gly Phe Ala Arg Ile Leu Met Pro Val Phe Gln Asp Thr

195 200 205Leu Asp Arg Ser Leu Ala Leu Ala Asn Ser Met Asp Ala Arg Gly Tyr

210 215 220Gly Arg Gln Ala His Val Ser Lys Phe Gln Gln Arg Val Thr Ser Ile225 230 235 240Phe Gly Ala Phe Gly Ile Leu Gly Val Thr Val Gly Leu Phe Val Val

245 250 255Leu Asp Ala Ser Ser Pro Met Phe Val Ala Val Pro Val Phe Ile Thr

260 265 270Gly Val Gly Phe Leu Ile Ile Ser Leu Val Val Ala Ser His Arg Lys

275 280 285Thr Ser Thr Thr Phe Asp Gln Leu Pro Trp Gly Ala Ala Glu Trp Leu

290 295 300Val Cys Ile Thr Gly Val Ile Pro Leu Leu Met Ala Ala Leu Thr Arg305 310 315 320Tyr Leu Asp Pro Gly Ser Met Ile Thr Thr Trp Val Pro Leu His Met

325 330 335Pro Asp Thr Val Pro Leu Leu Val Val Ala Gly Leu Val Val Ala Thr

340 345 350Met Pro Gly Phe Leu Thr Pro Arg Leu Pro Lys Asn Lys Val Arg Val

355 360 365Lys Arg Arg Lys Ala Ile Asn Ser Pro Glu Arg Ala Glu Val

370375380<210>433<211>876<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (853)<223>RXA00827<400>433tgcgtgaatt aacagacaac ggaatcagca ttgtgtcagt aacccatgat cctgatttca 60tcgcagcgct gggcgatcac cacattgagg tgagcgcgaa gtg aac ctg ctg atc 115

Val Asn Leu Leu Ile

1 5aaa att aat ccc gtc acc cgc atc atc gcg ttg atg gta ctg acc acg 163Lys Ile Asn Pro Val Thr Arg Ile Ile Ala Leu Met Val Leu Thr Thr

10 15 20ccg ttg ctg ctg agt ttg gat gtg atg tcg gca gcg atc gcg ctg gtg 211Pro Leu Leu Leu Ser Leu Asp Val Met Ser Ala Ala Ile Ala Leu Val

2530 35gca acc att att ctg gca cca ttt gcc ggc gtg acc tgg aag atg ctg 259Ala Thr Ile Ile Leu Ala Pro Phe Ala Gly Val Thr Trp Lys Met Leu

40 45 50ctg aaa cgt ggc tgg atg ctg ttc ctc atg gca ccg gtg gct gca tta 307Leu Lys Arg Gly Trp Met Leu Phe Leu Met Ala Pro Val Ala Ala Leu

55 60 65tcc atg gcg ctt tat ggc agg ccg gat gga aaa gag tac ttt agc ttc 355Ser Met Ala Leu Tyr Gly Arg Pro Asp Gly Lys Glu Tyr Phe Ser Phe 70 75 80 85ctg ctc att cac gtc act gat aat tca ctg gct ttg gct gct gcc att 403Leu Leu Ile His Val Thr Asp Asn Ser Leu Ala Leu Ala Ala Ala Ile

90 95 100ggg ctg cgt gtt ctg gcg att ggt ctg ccc gtt gtg gtg ctg att gct 451Gly Leu Arg Val Leu Ala Ile Gly Leu Pro Val Val Val Leu Ile Ala

105 110 115cgc att gat ccc acc gac ctg ggc gat ggt ttg gcg cag ctg ctc aaa 499Arg Ile Asp Pro Thr Asp Leu Gly Asp Gly Leu Ala Gln Leu Leu Lys

120 125 130ctg cct gaa agg ttt gtc atc ggt gct gtg gca gga agc cga ctg atg 547Leu Pro Glu Arg Phe Val Ile Gly Ala Val Ala Gly Ser Arg Leu Met

135 140 145acg ctt ttt cgg gaa gat tgg tac tcc atg tcc agg gca agg cgt gcc 595Thr Leu Phe Arg Glu Asp Trp Tyr Ser Met Ser Arg Ala Arg Arg Ala150 155 160 165cgc gga att gct gat cag ggc aag atc aag cac ttt ttc acc atg act 643Arg Gly Ile Ala Asp Gln Gly Lys Ile Lys His Phe Phe Thr Met Thr

170 175 180ttt ggt ttg ttg gtg ctc tcg ctt cgc cgt gga tcc aag ctt gca acg 691Phe Gly Leu Leu Val Leu Ser Leu Arg Arg Gly Ser Lys Leu Ala Thr

185 190 195gcg atg gaa gca cgc ggt ttt ggt cgc acg act ggc cgc acc tgg gca 739Ala Met Glu Ala Arg Gly Phe Gly Arg Thr Thr Gly Arg Thr Trp Ala

200 205 210agg gaa tcc acc gtc ggc gcg cgc gat ctg gtg ctc atc ttg gtg tgt 787Arg Glu Ser Thr Val Gly Ala Arg Asp Leu Val Leu Ile Leu Val Cys

215 220 225gct gcc att tcc gcg atc gct cta acc gtg tcc att cag act ggt ttc 835Ala Ala Ile Ser Ala Ile Ala Leu Thr Val Ser Ile Gln Thr Gly Phe230 235 240 245ttt aag ttc ttg ggc aca tgatcacagt tttaattgat gga 876Phe Lys Phe Leu Gly Thr

250<210>434<211>251<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>434Val Asn Leu Leu Ile Lys Ile Asn Pro Val Thr Arg Ile Ile Ala Leu 151015 Met Val Leu Thr Thr Pro Leu Leu Leu Ser Leu Asp Val Met Ser Ala

20 25 30Ala Ile Ala Leu Val Ala Thr Ile Ile Leu Ala Pro Phe Ala Gly Val

35 40 45Thr Trp Lys Met Leu Leu Lys Arg Gly Trp Met Leu Phe Leu Met Ala

50 55 60Pro Val Ala Ala Leu Ser Met Ala Leu Tyr Gly Arg Pro Asp Gly Lys 65 70 75 80Glu Tyr Phe Ser Phe Leu Leu Ile His Val Thr Asp Asn Ser Leu Ala

85 90 95Leu Ala Ala Ala Ile Gly Leu Arg Val Leu Ala Ile Gly Leu Pro Val

100 105 110Val Val Leu Ile Ala Arg Ile Asp Pro Thr Asp Leu Gly Asp Gly Leu

115120 125Ala Gln Leu Leu Lys Leu Pro Glu Arg Phe Val Ile Gly Ala Val Ala

130 135 140Gly Ser Arg Leu Met Thr Leu Phe Arg Glu Asp Trp Tyr Ser Met Ser145 150 155 160Arg Ala Arg Arg Ala Arg Gly Ile Ala Asp Gln Gly Lys Ile Lys His

165 170 175Phe Phe Thr Met Thr Phe Gly Leu Leu Val Leu Ser Leu Arg Arg Gly

180 185 190Ser Lys Leu Ala Thr Ala Met Glu Ala Arg Gly Phe Gly Arg Thr Thr

195 200 205Gly Arg Thr Trp Ala Arg Glu Ser Thr Val Gly Ala Arg Asp Leu Val

210 215 220Leu Ile Leu Val Cys Ala Ala Ile Ser Ala Ile Ala Leu Thr Val Ser225 230 235 240Ile Gln Thr Gly Phe Phe Lys Phe Leu Gly Thr

245250<210>435<211>732<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (709)<223>RXA00851<400>435ttgagcgggt catttgcatc aatgatcata aaatcgctgc tgatggccct ccgcaaaagt 60ccattgacct gtacgtatcg cttatggcgg aacctgcgaa atg aac agt att cct 115

Met Asn Ser Ile Pro

1 5tta ggt ttt tac gtc gat aag caa tct gtt gtt cat tct ttt cct gct 163Leu Gly Phe Tyr Val Asp Lys Gln Ser Val Val His Ser Phe Pro Ala

10 15 20ttg tgg aaa ttc cca ctt ctg ctg ttt ttc atc atc ggc ggc tcc atc 211Leu Trp Lys Phe Pro Leu Leu Leu Phe Phe Ile Ile Gly Gly Ser Ile

25 30 35gcg gct tct acc ccg gtt cat ggg ttg att ttg gtg ggg att gca gtg 259Ala Ala Ser Thr Pro Val His Gly Leu Ile Leu Val Gly Ile Ala Val

40 45 50gtg ttt tac gtg ctg gcg aag att ccg ctg aag gtc gcg tgg gag cag 307Val Phe Tyr Val Leu Ala Lys Ile Pro Leu Lys Val Ala Trp Glu Gln

55 60 65ttg tgg cca gtg ctg ccg att ttg atc atg ctc ggt gcg ttt cag tgg 355Leu Trp Pro Val Leu Pro Ile Leu Ile Met Leu Gly Ala Phe Gln Trp 70 75 80 85tgg cag cgc ggc ttt gat ttc gcg gca acc aca gtg ctc acg ctg ttt 403Trp Gln Arg Gly Phe Asp Phe Ala Ala Thr Thr Val Leu Thr Leu Phe

90 95 100tcc gcg gtg atg gcc gcc atg ttg ttg acg ttg acc acg cgg ttg gaa 451Ser Ala Val Met Ala Ala Met Leu Leu Thr Leu Thr Thr Arg Leu Glu

105 110 115gcg ctc atg aat gca gtt gag cgg atg ttg cag cct ttt gca cgt ttt 499Ala Leu Met Asn Ala Val Glu Arg Met Leu Gln Pro Phe Ala Arg Phe

120 125 130ggc ctg cca gta gag acg atc acc ttg gct att tct ctc acg att cgg 547Gly Leu Pro Val Glu Thr Ile Thr Leu Ala Ile Ser Leu Thr Ile Arg

135 140 145ctc att ccg ctg caa tta gcc acg gtg aag gaa gtc ctc gat gcc cgt 595Leu Ile Pro Leu Gln Leu Ala Thr Val Lys Glu Val Leu Asp Ala Arg150 155 160 165aaa gct cgt ggt gcc ggt ttt tct atc gcc gcg ttt ggc acg cct gtg 643Lys Ala Arg Gly Ala Gly Phe Ser Ile Ala Ala Phe Gly Thr Pro Val

170 175 180atc atc aga tca ata aag agg gcc cgc aat atcggc gat gct ctt ctc 691Ile Ile Arg Ser Ile Lys Arg Ala Arg Asn Ile Gly Asp Ala Leu Leu

185 190 195gca cgt ggt gcc ggc gat taatttcttt caacacatag caa 732Ala Arg Gly Ala Gly Asp

200<210>436<211>203<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>436Met Asn Ser Ile Pro Leu Gly Phe Tyr Val Asp Lys Gln Ser Val Val 151015 His Ser Phe Pro Ala Leu Trp Lys Phe Pro Leu Leu Leu Phe Phe Ile

20 25 30Ile Gly Gly Ser Ile Ala Ala Ser Thr Pro Val His Gly Leu Ile Leu

35 40 45Val Gly Ile Ala Val Val Phe Tyr Val Leu Ala Lys Ile Pro Leu Lys

50 55 60Val Ala Trp Glu Gln Leu Trp Pro Val Leu Pro Ile Leu Ile Met Leu 65 70 75 80Gly Ala Phe Gln Trp Trp Gln Arg Gly Phe Asp Phe Ala Ala Thr Thr

85 90 95Val Leu Thr Leu Phe Ser Ala Val Met Ala Ala Met Leu Leu Thr Leu

100 105 110Thr Thr Arg Leu Glu Ala Leu Met Asn Ala Val Glu Arg Met Leu Gln

115 120 125Pro Phe Ala Arg Phe Gly Leu Pro Val Glu Thr Ile Thr Leu Ala Ile

130 135 140Ser Leu Thr Ile Arg Leu Ile Pro Leu Gln Leu Ala Thr Val Lys Glu145 150 155 160Val Leu Asp Ala Arg Lys Ala Arg Gly Ala Gly Phe Ser Ile Ala Ala

165 170 175Phe Gly Thr Pro Val Ile Ile Arg Ser Ile Lys Arg Ala Arg Asn Ile

180 185 190Gly Asp Ala Leu Leu Ala Arg Gly Ala Gly Asp

195200<210>437<211>725<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(3) } (695)<223>RXS03220<400>437cc atg ggc tta agg gaa att ttg tcc agc aag tgg ctt gtg cgc atc 47 Met Gly Leu Arg Glu Ile Leu Ser Ser Lys Trp Leu Val Arg Ile

1 5 10 15ctc ctg gta ggt atc gga ttg ggt gtc gca cag cag ctg acc ggc atc 95Leu Leu Val Gly Ile Gly Leu Gly Val Ala Gln Gln Leu Thr Gly Ile

20 25 30aac tcc atc atg tac tac ggc cag gtt gtt ctc att gag gct ggt ttc 143Asn Ser Ile Met Tyr Tyr Gly Gln Val Val Leu Ile Glu Ala Gly Phe

35 40 45tcc gag aat gca gct ctg atc gcc aac gtg gcg cca gga gtg atc gca 191Ser Glu Asn Ala Ala Leu Ile Ala Asn Val Ala Pro Gly Val Ile Ala

50 55 60gtt gtc ggt gca ttc atc gca ctg tgg atg atg gat ggt atc aac cgc 239Val Val Gly Ala Phe Ile Ala Leu Trp Met Met Asp Gly Ile Asn Arg

65 70 75cgt acc acc ctc att acc ggt tat tct ctc acc acc att agc cac gta 287Arg Thr Thr Leu Ile Thr Gly Tyr Ser Leu Thr Thr Ile Ser His Val 80 85 90 95ttg atc ggt atc gca tcc gta gca ttc cca gtc ggc gat cct ctt cgc 335Leu Ile Gly Ile Ala Ser Val Ala Phe Pro Val Gly Asp Pro Leu Arg

100 105 110ccc tac gtt atc ttg act ctg gtt gtg gtc ttc gtg gga tcc atg cag 383Pro Tyr Val Ile Leu Thr Leu Val Val Val Phe Val Gly Ser Met Gln

115 120 125acc ttc ctc aac gta gct acc tgg gtt atg ctc tct gag ctc ttc ccg 431Thr Phe Leu Asn Val Ala Thr Trp Val Met Leu Ser Glu Leu Phe Pro

130 135 140ctg gca atg cgc ggt ttc gca atc ggt atc tca gtg ttc ttc ctc tgg 479Leu Ala Met Arg Gly Phe Ala Ile Gly Ile Ser Val Phe Phe Leu Trp

145 150 155atc gca aac gcg ttc ctc gga ttg ttc ttc cca acc atc atg gaa gca 527Ile Ala Asn Ala Phe Leu Gly Leu Phe Phe Pro Thr Ile Met Glu Ala160 165 170 175gta gga cta acc gga acc ttc ttc atg ttc gcc gga atc ggt gtg gtt 575Val Gly Leu Thr Gly Thr Phe Phe Met Phe Ala Gly Ile Gly Val Val

180 185 190gcc ttg atc ttc atc tac acc cag gtt cct gaa act cgt gga cgt acc 623Ala Leu Ile Phe Ile Tyr Thr Gln Val Pro Glu Thr Arg Gly Arg Thr

195 200 205ttg gag gag att gat gag gat gtt act tcc ggt gtc att tte aac aag 671Leu Glu Glu Ile Asp Glu Asp Val Thr Ser Gly Val Ile Phe Asn Lys

210 215 220gac atc cga aaa gga aag gtg cac taaaaaccca gacactgcat agataacacg 725Asp Ile Arg Lys Gly Lys Val His

225230<210>438<211>231<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>438Met Gly Leu Arg Glu Ile Leu Ser Ser Lys Trp Leu Val Arg Ile Leu 151015 Leu Val Gly Ile Gly Leu Gly Val Ala Gln Gln Leu Thr Gly Ile Asn

20 25 30Ser Ile Met Tyr Tyr Gly Gln Val Val Leu Ile Glu Ala Gly Phe Ser

35 40 45Glu Asn Ala Ala Leu Ile Ala Asn Val Ala Pro Gly Val Ile Ala Val

50 55 60Val Gly Ala Phe Ile Ala Leu Trp Met Met Asp Gly Ile Asn Arg Arg 65 70 75 80Thr Thr Leu Ile Thr Gly Tyr Ser Leu Thr Thr Ile Ser His Val Leu

85 90 95Ile Gly Ile Ala Ser Val Ala Phe Pro Val Gly Asp Pro Leu Arg Pro

100 105 110Tyr Val Ile Leu Thr Leu Val Val Val Phe Val Gly Ser Met Gln Thr

115 120 125Phe Leu Asn Val Ala Thr Trp Val Met Leu Ser Glu Leu Phe Pro Leu

130 135 140Ala Met Arg Gly Phe Ala Ile Gly Ile Ser Val Phe Phe Leu Trp Ile145 150 155 160Ala Asn Ala Phe Leu Gly Leu Phe Phe Pro Thr Ile Met Glu Ala Val

165 170 175Gly Leu Thr Gly Thr Phe Phe Met Phe Ala Gly Ile Gly Val Val Ala

180 185 190Leu Ile Phe Ile Tyr Thr Gln Val Pro Glu Thr Arg Gly Arg Thr Leu

195 200 205Glu Glu Ile Asp Glu Asp Val Thr Ser Gly Val Ile Phe Asn Lys Asp

210215220 Ile Arg Lys Gly Lys Val His 225230<210>439<211>408<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<385><223>FRXA02762<400>439ttcccagtcg gcgatcctct tcgcccctac gttatcttga ctctggttgt ggtcttcgtg 60ggatccatgc agaccttcct caacggtagc tacctgggtt atg ctc tct gag ctc 115

Met Leu Ser Glu Leu

1 5ttc ccg ctg gca atg cgc ggt ttc gca atc ggt atc tca gtg ttc ttc 163Phe Pro Leu Ala Met Arg Gly Phe Ala Ile Gly Ile Ser Val Phe Phe

10 15 20ctc tgg atc gca aac gcg ttc ctc gga ttg ttc ttc cca acc atc atg 211Leu Trp Ile Ala Asn Ala Phe Leu Gly Leu Phe Phe Pro Thr Ile Met

25 30 35gaa gca gta gga cta acc gga acc ttc ttc atg ttc gcc gga atc ggt 259Glu Ala Val Gly Leu Thr Gly Thr Phe Phe Met Phe Ala Gly Ile Gly

40 45 50gtg gtt gcc ttg atc ttc atc tac acc cag gtt cct gaa act cgt gga 307Val Val Ala Leu Ile Phe Ile Tyr Thr Gln Val Pro Glu Thr Arg Gly

55 60 65cgt acc ttg gag gag att gat gag gat gtt act tcc ggt gtc att ttc 355Arg Thr Leu Glu Glu Ile Asp Glu Asp Val Thr Ser Gly Val Ile Phe 70 75 80 85aac aag gac atc cga aaa gga aag gtg cac taaaaaccca gacactgcat 405Asn Lys Asp Ile Arg Lys Gly Lys Val His

9095 aga 408<210>440<211>95<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>440Met Leu Ser Glu Leu Phe Pro Leu Ala Met Arg Gly Phe Ala Ile Gly 151015 Ile Ser Val Phe Phe Leu Trp Ile Ala Asn Ala Phe Leu Gly Leu Phe

20 25 30Phe Pro Thr Ile Met Glu Ala Val Gly Leu Thr Gly Thr Phe Phe Met

35 40 45Phe Ala Gly Ile Gly Val Val Ala Leu Ile Phe Ile Tyr Thr Gln Val

50 55 60Pro Glu Thr Arg Gly Arg Thr Leu Glu Glu Ile Asp Glu Asp Val Thr 65 70 75 80Ser Gly Val Ile Phe Asn Lys Asp Ile Arg Lys Gly Lys Val His

859095<210>441<211>789<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (766)<223>RXN00092<400>441cgaaaccaga aacacccagc ggctcctcgt cgaaaagcga atctttgaac tagaagccca 60ggcacgttgg ctcgaccgaa ttgaagcatt ggagcagtaa atg aca aac acg cct 115

Met Thr Asn Thr Pro

1 5ttc ccc ctt gaa ctt caa aac atc tcc tgc gcc ttc gga gaa ggc cca 163Phe Pro Leu Glu Leu Gln Asn Ile Ser Cys Ala Phe Gly Glu Gly Pro

10 15 20cgc cac gtc tcc gcg ctc aac aac gtc tcg ctg gca gtc aat ccc ggc 211Arg His Val Ser Ala Leu Asn Asn Val Ser Leu Ala Val Asn Pro Gly

25 30 35gaa ctc gtt gcc atc atg ggc ccg tcc ggc tca gga aaa tcc acc ttg 259Glu Leu Val Ala Ile Met Gly Pro Ser Gly Ser Gly Lys Ser Thr Leu

40 45 50ctc aac gtc gcc ggc ctc ctg cag cgc gca acc tct ggc cat gtg ctt 307Leu Asn Val Ala Gly Leu Leu Gln Arg Ala Thr Ser Gly His Val Leu

55 60 65atc gac ggt gcc agc gcc tca gac ctc aac gcc aaa cgc gca gct gaa 355Ile Asp Gly Ala Ser Ala Ser Asp Leu Asn Ala Lys Arg Ala Ala Glu 70 75 80 85acc agg cgt cgc cac atc gga gtt att ttc caa aac tac aac ctg gtc 403Thr Arg Arg Arg His Ile Gly Val Ile Phe Gln Asn Tyr Asn Leu Val

90 95 100ccc acc ctc acc gtc gga gaa aac gtc ggt ctg ccc cta gaa ctc gac 451Pro Thr Leu Thr Val Gly Glu Asn Val Gly Leu Pro Leu Glu Leu Asp

105 110 115ggc aaa acc gac cgc cag gca gta gca atc gca ctc gcg gaa gtc ggc 499Gly Lys Thr Asp Arg Gln Ala Val Ala Ile Ala Leu Ala Glu Val Gly

120 125 130ctc gaa ggc ttc gac gac cgc ttc ccc gaa gag atc tcc ggc ggc caa 547Leu Glu Gly Phe Asp Asp Arg Phe Pro Glu Glu Ile Ser Gly Gly Gln

135 140 145gcc cag cgc gtc gcc atc gcg aga gcc crc arc ggc ccc cga aaa atc 595Ala Gln Arg Val Ala Ile Ala Arg Ala Leu Ile Gly Pro Arg Lys Ile150 155 160 165ttg ctt gcc gac gaa ccc acc ggc gcc ctc gac acc tcc acc ggc gac 643Leu Leu Ala Asp Glu Pro Thr Gly Ala Leu Asp Thr Ser Thr Gly Asp

170 175 180gca gtc ctc cgc gtc ctc cgc caa aga atc gat tcc ggt gcc gca ggc 691Ala Val Leu Arg Val Leu Arg Gln Arg Ile Asp Ser Gly Ala Ala Gly

185 190 195ctc ctt gtc acc cac gaa ccc cgc ttc gcc gcg tgg gca gac cga aca 739Leu Leu Val Thr His Glu Pro Arg Phe Ala Ala Trp Ala Asp Arg Thr

200 205 210atc atg ctt agg gat ggt gaa atc cag tgaccacact tctagcagca 786Ile Met Leu Arg Asp Gly Glu Ile Gln

215220 acc 789<210>442<211>222<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>442Met Thr Asn Thr Pro Phe Pro Leu Glu Leu Gln Asn Ile Ser Cys Ala 151015 Phe Gly Glu Gly Pro Arg His Val Ser Ala Leu Asn Asn Val Ser Leu

20 25 30Ala Val Asn Pro Gly Glu Leu Val Ala Ile Met Gly Pro Ser Gly Ser

35 40 45Gly Lys Ser Thr Leu Leu Asn Val Ala Gly Leu Leu Gln Arg Ala Thr

50 55 60Ser Gly His Val Leu Ile Asp Gly Ala Ser Ala Ser Asp Leu Asn Ala 65 70 75 80Lys Arg Ala Ala Glu Thr Arg Arg Arg His Ile Gly Val Ile Phe Gln

85 90 95Asn Tyr Asn Leu Val Pro Thr Leu Thr Val Gly Glu Asn Val Gly Leu

100 105 110Pro Leu Glu Leu Asp Gly Lys Thr Asp Arg Gln Ala Val Ala Ile Ala

115 120 125Leu Ala Glu Val Gly Leu Glu Gly Phe Asp Asp Arg Phe Pro Glu Glu

130 135 140Ile Ser Gly Gly Gln Ala Gln Arg Val Ala Ile Ala Arg Ala Leu Ile145 150 155 160Gly Pro Arg Lys Ile Leu Leu Ala Asp Glu Pro Thr Gly Ala Leu Asp

165 170 175Thr Ser Thr Gly Asp Ala Val Leu Arg Val Leu Arg Gln Arg Ile Asp

180 185 190Ser Gly Ala Ala Gly Leu Leu Val Thr His Glu Pro Arg Phe Ala Ala

195 200 205Trp Ala Asp Arg Thr Ile Met Leu Arg Asp Gly Glu Ile Gln

210215220<210>443<211>227<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (204)<223>FRXA00092<400>443atc gcg aga gcc ctc atc ggc ccc cga aaa atc ttg ctt gcc gac gaa 48Ile Ala Arg Ala Leu Ile Gly Pro Arg Lys Ile Leu Leu Ala Asp Glu 151015 ccc acc ggc gcc ctc gac acc tcc acc ggc gac gca gtc ctc cgc gtc 96Pro Thr Gly Ala Leu Asp Thr Ser Thr Gly Asp Ala Val Leu Arg Val

20 25 30ctc cgc caa aga atc gat tcc ggt gcc gca ggc ctc ctt gtc acc cac 144Leu Arg Gln Arg Ile Asp Ser Gly Ala Ala Gly Leu Leu Val Thr His

35 40 45gaa ccc cgc ttc gcc gcg tgg gca gac cga aca atc atg ctt agg gat 192Glu Pro Arg Phe Ala Ala Trp Ala Asp Arg Thr Ile Met Leu Arg Asp

505560 ggt gaa atc cag tgaccacact tctagcagca acc 227Gly Glu Ile Gln 65<210>444<211>68<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>444Ile Ala Arg Ala Leu Ile Gly Pro Arg Lys Ile Leu Leu Ala Asp Glu 151015 Pro Thr Gly Ala Leu Asp Thr Ser Thr Gly Asp Ala Val Leu Arg Val

20 25 30Leu Arg Gln Arg Ile Asp Ser Gly Ala Ala Gly Leu Leu Val Thr His

35 40 45Glu Pro Arg Phe Ala Ala Trp Ala Asp Arg Thr Ile Met Leu Arg Asp

505560 Gly Glu Ile Gln 65<65>445<211>975<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<952><223>RXN03060<400>445tatgtccttt ggctccggta ccctggcagg agtacctggg ctgtttttct aaaatggcct 60gacgttttca agattgaatt taaggaaagc atcgtagttc atg agt aac cct gcc 115

Met Ser Asn Pro Ala

1 5gcg agc aca cct gcc aac aat tcg gac gat gtt gcg aag gag aat tgg 163Ala Ser Thr Pro Ala Asn Asn Ser Asp Asp Val Ala Lys Glu Asn Trp

10 15 20gac tct tct ttt acg ccg aag act gac att gac tct tcc cag cct gtc 211Asp Ser Ser Phe Thr Pro Lys Thr Asp Ile Asp Ser Ser Gln Pro Val

25 30 35aat aac tcg act ggt gaa gcc gct gcg cgc gca gtg aac ctg tac aag 259Asn Asn Ser Thr Gly Glu Ala Ala Ala Arg Ala Val Asn Leu Tyr Lys

40 45 50gcg tat ggc cag ggt gat acc act gtc acc gcg ttg gat cac gtc aac 307Ala Tyr Gly Gln Gly Asp Thr Thr Val Thr Ala Leu Asp His Val Asn

55 60 65gtg gag ttt gag aag aac aag ttc act gcc atc atg ggt cct tct ggc 355Val Glu Phe Glu Lys Asn Lys Phe Thr Ala Ile Met Gly Pro Ser Gly 70 75 80 85tcg ggt aag tcc acg ttg atg cac tgc atg gct ggt ctg gat gct gcg 403Ser Gly Lys Ser Thr Leu Met His Cys Met Ala Gly Leu Asp Ala Ala

90 95 100act ggt ggt tcg gca ttc att ggt gat acg gat ctg tcg cgg ttg aag 451Thr Gly Gly Ser Ala Phe Ile Gly Asp Thr Asp Leu Ser Arg Leu Lys

105 110 115gac aaa gag atg acc tct ttg cgt cgt gat cgt ttg gga ttc att ttc 499Asp Lys Glu Met Thr Ser Leu Arg Arg Asp Arg Leu Gly Phe Ile Phe

120 125 130cag tcg ttc aac ttg gtt cct act ctg acg gcg tcg gag aac att acg 547Gln Ser Phe Asn Leu Val Pro Thr Leu Thr Ala Ser Glu Asn Ile Thr

135 140 145ctg cct acc gat atc gcg ggc cgc aag att gat cag tcg tgg ttc gat 595Leu Pro Thr Asp Ile Ala Gly Arg Lys Ile Asp Gln Ser Trp Phe Asp150 155 160 165gag att acc tct cgt ctg ggt ctg act gag cgc ctt aag cac cgt cct 643Glu Ile Thr Ser Arg Leu Gly Leu Thr Glu Arg Leu Lys His Arg Pro

170 175 180gca gag ctc tct ggt ggt cag cag cag cgtgtg gcg tgt gct cgt gcg 691Ala Glu Leu Ser Gly Gly Gln Gln Gln Arg Val Ala Cys Ala Arg Ala

185 190 195ttg gtg tct cgt ccg gag atc att ttc ggc gac gag cca acc ggt aac 739Leu Val Ser Arg Pro Glu Ile Ile Phe Gly Asp Glu Pro Thr Gly Asn

200 205 210ttg gat tcg aac tct tct agg gaa gtg ctg gat atc ctg cgc acc gca 787Leu Asp Ser Asn Ser Ser Arg Glu Val Leu Asp Ile Leu Arg Thr Ala

215 220 225gtt gat cag gat gat cag acc gtt gtg atc gtt acc cac gat gcc aag 835Val Asp Gln Asp Asp Gln Thr Val Val Ile Val Thr His Asp Ala Lys230 235 240 245gcg gcg tcc tat gca gat cgt gtc att ttc ttg gcg gac ggt cgt atc 883Ala Ala Ser Tyr Ala Asp Arg Val Ile Phe Leu Ala Asp Gly Arg Ile

250 255 260gtg aac cag ttg ttt gat ccc acc atc gag gaa atc ttg gcc acg atg 931Val Asn Gln Leu Phe Asp Pro Thr Ile Glu Glu Ile Leu Ala Thr Met

265 270 275aac gga att gag gat att gcc taatgaattc cggttccaca atg 975Asn Gly Ile Glu Asp Ile Ala

280<210>446<211>284<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>446Met Ser Asn Pro Ala Ala Ser Thr Pro Ala Asn Asn Ser Asp Asp Val 151015 Ala Lys Glu Asn Trp Asp Ser Ser Phe Thr Pro Lys Thr Asp Ile Asp

20 25 30Ser Ser Gln Pro Val Asn Asn Ser Thr Gly Glu Ala Ala Ala Arg Ala

35 40 45Val Asn Leu Tyr Lys Ala Tyr Gly Gln Gly Asp Thr Thr Val Thr Ala

50 55 60Leu Asp HisVal Asn Val Glu Phe Glu Lys Asn Lys Phe Thr Ala Ile 65 70 75 80Met Gly Pro Ser Gly Ser Gly Lys Ser Thr Leu Met His Cys Met Ala

85 90 95Gly Leu Asp Ala Ala Thr Gly Gly Ser Ala Phe Ile Gly Asp Thr Asp

100 105 110Leu Ser Arg Leu Lys Asp Lys Glu Met Thr Ser Leu Arg Arg Asp Arg

115 120 125Leu Gly Phe Ile Phe Gln Ser Phe Asn Leu Val Pro Thr Leu Thr Ala

130 135 140Ser Glu Asn Ile Thr Leu Pro Thr Asp Ile Ala Gly Arg Lys Ile Asp145 150 155 160Gln Ser Trp Phe Asp Glu Ile Thr Ser Arg Leu Gly Leu Thr Glu Arg

165 170 175Leu Lys His Arg Pro Ala Glu Leu Ser Gly Gly Gln Gln Gln Arg Val

180 185 190Ala Cys Ala Arg Ala Leu Val Ser Arg Pro Glu Ile Ile Phe Gly Asp

195 200 205Glu Pro Thr Gly Asn Leu Asp Ser Asn Ser Ser Arg Glu Val Leu Asp

210 215 220Ile Leu Arg Thr Ala Val Asp Gln Asp Asp Gln Thr Val Val Ile Val225 230 235 240Thr His Asp Ala Lys Ala Ala Ser Tyr Ala Asp Arg Val Ile Phe Leu

245 250 255Ala Asp Gly Arg Ile Val Asn Gln Leu Phe Asp Pro Thr Ile Glu Glu

260 265 270Ile Leu Ala Thr Met Asn Gly Ile Glu Asp Ile Ala

275280<210>447<211>538<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (538)<223>FRXA02618<400>447cgaaaccaga aacacccagc ggctcctcgt cgaaaagcga atctttgaac tagaagccca 60ggcacgttgg ctcgaccgaa ttgaagcatt ggagcagtaa atg aca aac acg cct 115

Met Thr Asn Thr Pro

1 5ttc ccc ctt gaa ctt caa aac atc tcc tgc gcc ttc gga gaa ggc cca 163Phe Pro Leu Glu Leu Gln Asn Ile Ser Cys Ala Phe Gly Glu Gly Pro

10 15 20cgc cac gtc tcc gcg ctc aac aac gtc tcg ctg gca gtc aat ccc ggc 211Arg His Val Ser Ala Leu Asn Asn Val Ser Leu Ala Val Asn Pro Gly

25 30 35gaa ctc gtt gcc atc atg ggc ccg tcc ggc tca gga aaa tcc acc ttg 259Glu Leu Val Ala Ile Met Gly Pro Ser Gly Ser Gly Lys Ser Thr Leu

40 45 50ctc aac gtc gcc ggc ctc ctg cag cgc gca acc tct ggc cat gtg ctt 307Leu Asn Val Ala Gly Leu Leu Gln Arg Ala Thr Ser Gly His Val Leu

55 60 65atc gac ggt gcc agc gcc tca gac ctc aac gcc aaa cgc gca gct gaa 355Ile Asp Gly Ala Ser Ala Ser Asp Leu Asn Ala Lys Arg Ala Ala Glu 70 75 80 85acc agg cgt cgc cac atc gga gtt att ttc caa aac tac aac ctg gtc 403Thr Arg Arg Arg His Ile Gly Val Ile Phe Gln Asn Tyr Asn Leu Val

90 95 100ccc acc ctc acc gtc gga gaa aac atc ggt ctg ccc cra gaa crc gac 451Pro Thr Leu Thr Val Gly Glu Asn Ile Gly Leu Pro Leu Glu Leu Asp

105 110 115ggc aaa acc gac cgc cag gca gta gca atc gca ctc gcg gaa gtc ggc 499Gly Lys Thr Asp Arg Gln AlaVal Ala Ile Ala Leu Ala Glu Val Gly

120 125 130ctc aag ggc tct acg acc gct ttt ccc gag aga tct ctg 538Leu Lys Gly Ser Thr Thr Ala Phe Pro Glu Arg Ser Leu

135140145<210>448<211>146<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>448Met Thr Asn Thr Pro Phe Pro Leu Glu Leu Gln Asn Ile Ser Cys Ala 151015 Phe Gly Glu Gly Pro Arg His Val Ser Ala Leu Asn Asn Val Ser Leu

20 25 30Ala Val Asn Pro Gly Glu Leu Val Ala Ile Met Gly Pro Ser Gly Ser

35 40 45Gly Lys Ser Thr Leu Leu Asn Val Ala Gly Leu Leu Gln Arg Ala Thr

50 55 60Ser Gly His Val Leu Ile Asp Gly Ala Ser Ala Ser Asp Leu Asn Ala 65 70 75 80Lys Arg Ala Ala Glu Thr Arg Arg Arg His Ile Gly Val Ile Phe Gln

85 90 95Asn Tyr Asn Leu Val Pro Thr Leu Thr Val Gly Glu Asn Ile Gly Leu

100 105 110Pro Leu Glu Leu Asp Gly Lys Thr Asp Arg Gln Ala Val Ala Ile Ala

115 120 125Leu Ala Glu Val Gly Leu Lys Gly Ser Thr Thr Ala Phe Pro Glu Arg

130135140 Ser Leu145<210>449<211>975<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (952)<223>FRXA02900<400>449tatgtccttt ggctccggta ccctggcagg agtacctggg ctgtttttct aaaatggcct 60gacgttttca agattgaatt taaggaaagc atcgtagttc atg agt aac cct gcc 115

Met Ser Asn Pro Ala

1 5gcg agc aca cct gcc aac aat tcg gac gat gtt gcg aag gag aat tgg 163Ala Ser Thr Pro Ala Asn Asn Ser Asp Asp Val Ala Lys Glu Asn Trp

10 15 20gac tct tct ttt acg ccg aag act gac att gac tct tcc cag cct gtc 211Asp Ser Ser Phe Thr Pro Lys Thr Asp Ile Asp Ser Ser Gln Pro Val

25 30 35aat aac tcg act ggt gaa gcc gct gcg cgc gca gtg aac ctg tac aag 259Asn Asn Ser Thr Gly Glu Ala Ala Ala Arg Ala Val Asn Leu Tyr Lys

40 45 50gcg tat ggc cag ggt gat acc act gtc acc gcg ttg gat cac gtc aac 307Ala Tyr Gly Gln Gly Asp Thr Thr Val Thr Ala Leu Asp His Val Asn

55 60 65gtg gag ttt gag aag aac aag ttc act gcc atc atg ggt cct tct ggc 355Val Glu Phe Glu Lys Asn Lys Phe Thr Ala Ile Met Gly Pro Ser Gly 70 75 80 85tcg ggt aag tcc acg ttg atg cac tgc atg gct ggt ctg gat gct gcg 403Ser Gly Lys Ser Thr Leu Met His Cys Met Ala Gly Leu Asp Ala Ala

90 95 100act ggt ggt tcg gca ttc att ggt gat acg gat ctg tcg cgg ttg aag 451Thr Gly Gly Ser Ala Phe Ile Gly Asp Thr Asp Leu Ser Arg Leu Lys

105 110 115gac aaa gag atg acc tct ttg cgt cgt gat cgt ttg gga ttc att ttc 499Asp Lys Glu Met Thr Ser Leu Arg Arg Asp Arg Leu Gly Phe Ile Phe

120 125 130cag tcg ttc aac ttg gtt cct act ctg acg gcg tcg gag aac att acg 547Gln Ser Phe Asn Leu Val Pro Thr Leu Thr Ala Ser Glu Asn Ile Thr

135140 145ctg cct acc gat atc gcg ggc cgc aag att gat cag tcg tgg ttc gat 595Leu Pro Thr Asp Ile Ala Gly Arg Lys Ile Asp Gln Ser Trp Phe Asp150 155 160 165gag att acc tct cgt ctg ggt ctg act gag cgc ctt aag cac cgt cct 643Glu Ile Thr Ser Arg Leu Gly Leu Thr Glu Arg Leu Lys His Arg Pro

170 175 180gca gag ctc tct ggt ggt cag cag cag cgt gtg gcg tgt gct cgt gcg 691Ala Glu Leu Ser Gly Gly Gln Gln Gln Arg Val Ala Cys Ala Arg Ala

185 190 195ttg gtg tct cgt ccg gag atc att ttc ggc gac gag cca acc ggt aac 739Leu Val Ser Arg Pro Glu Ile Ile Phe Gly Asp Glu Pro Thr Gly Asn

200 205 210ttg gat tcg aac tct tct agg gaa gtg ctg gat atc ctg cgc acc gca 787Leu Asp Ser Asn Ser Ser Arg Glu Val Leu Asp Ile Leu Arg Thr Ala

215 220 225gtt gat cag gat gat cag acc gtt gtg atc gtt acc cac gat gcc aag 835Val Asp Gln Asp Asp Gln Thr Val Val Ile Val Thr His Asp Ala Lys230 235 240 245gcg gcg tcc tat gca gat cgt gtc att ttc ttg gcg gac ggt cgt atc 883Ala Ala Ser Tyr Ala Asp Arg Val Ile Phe Leu Ala Asp Gly Arg Ile

250 255 260gtg aac cag ttg ttt gat ccc acc atc gag gaa atc ttg gcc acg atg 931Val Asn Gln Leu Phe Asp Pro Thr Ile Glu Glu Ile Leu Ala Thr Met

265 270 275aac gga att gag gat att gcc taatgaattc cggttccaca atg 975Asn Gly Ile Glu Asp Ile Ala

280<210>450<211>284<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>450Met Ser Asn Pro Ala Ala Ser Thr Pro Ala Asn Asn Ser Asp Asp Val 151015 Ala Lys Glu Asn Trp Asp Ser Ser Phe Thr Pro Lys Thr Asp Ile Asp

20 25 30Ser Ser Gln Pro Val Asn Asn Ser Thr Gly Glu Ala Ala Ala Arg Ala

35 40 45Val Asn Leu Tyr Lys Ala Tyr Gly Gln Gly Asp Thr Thr Val Thr Ala

50 55 60Leu Asp His Val Asn Val Glu Phe Glu Lys Asn Lys Phe Thr Ala Ile 65 70 75 80Met Gly Pro Ser Gly Ser Gly Lys Ser Thr Leu Met His Cys Met Ala

85 90 95Gly Leu Asp Ala Ala Thr Gly Gly Ser Ala Phe Ile Gly Asp Thr Asp

100 105 110Leu Ser Arg Leu Lys Asp Lys Glu Met Thr Ser Leu Arg Arg Asp Arg

115 120 125Leu Gly Phe Ile Phe Gln Ser Phe Asn Leu Val Pro Thr Leu Thr Ala

130 135 140Ser Glu Asn Ile Thr Leu Pro Thr Asp Ile Ala Gly Arg Lys Ile Asp145 150 155 160Gln Ser Trp Phe Asp Glu Ile Thr Ser Arg Leu Gly Leu Thr Glu Arg

165 170 175Leu Lys His Arg Pro Ala Glu Leu Ser Gly Gly Gln Gln Gln Arg Val

180 185 190Ala Cys Ala Arg Ala Leu Val Ser Arg Pro Glu Ile Ile Phe Gly Asp

195 200 205Glu Pro Thr Gly Asn Leu Asp Ser Asn Ser Ser Arg Glu Val Leu Asp

210 215 220Ile Leu Arg Thr Ala Val Asp Gln Asp Asp Gln Thr Val Val Ile Val225 230 235240Thr His Asp Ala Lys Ala Ala Ser Tyr Ala Asp Arg Val Ile Phe Leu

245 250 255Ala Asp Gly Arg Ile Val Asn Gln Leu Phe Asp Pro Thr Ile Glu Glu

260 265 270Ile Leu Ala Thr Met Asn Gly Ile Glu Asp Ile Ala

275280<210>451<211>1452<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1).<1452><223>RXS03212<400>451gcc tca ctt aac tgg tca gtc atc gtt cca gcc cta gtc att gtc cta 48Ala Ser Leu Asn Trp Ser Val Ile Val Pro Ala Leu Val Ile Val Leu 151015 gcg aca gtg gtg tgg ggt atc gga ttc aaa gat agc ttt acc aac ttt 96Ala Thr Val Val Trp Gly Ile Gly Phe Lys Asp Ser Phe Thr Asn Phe

20 25 30gct agt tct gcg ttg tca gca gta gtt gac aat ctc ggc tgg gcc ttc 144Ala Ser Ser Ala Leu Ser Ala Val Val Asp Asn Leu Gly Trp Ala Phe

35 40 45att ttg ttt ggc aca gtc ttt gta ttt ttt atc gtt gtt atc gcc gct 192Ile Leu Phe Gly Thr Val Phe Val Phe Phe Ile Val Val Ile Ala Ala

50 55 60agt aaa ttc ggc acg att cgc tta ggc cgc att gat gaa gca cca gag 240Ser Lys Phe Gly Thr Ile Arg Leu Gly Arg Ile Asp Glu Ala Pro Glu 65 70 75 80ttt cgc acg gtg tca tgg att tcc atg atg ttt gct gca ggt atg ggt 288Phe Arg Thr Val Ser Trp Ile Ser Met Met Phe Ala Ala Gly Met Gly

85 90 95att ggt ttg atg ttc tac gga acc aca gaa cct tta acc ttc tac cgc 336Ile Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe Tyr Arg

100 105 110aat ggt gta cct gga cat gat gaa cac aat gtt ggc gtt gct atg tcc 384Asn Gly Val Pro Gly His Asp Glu His Asn Val Gly Val Ala Met Ser

115 120 125acg aca atg ttc cac tgg acc ttg cat cca tgg gct atc tac gca att 432Thr Thr Met Phe His Trp Thr Leu His Pro Trp Ala Ile Tyr Ala Ile

130 135 140gtg ggc cta gcc att gcc tat tcg acc ttc cga gtg ggc cgt aaa cag 480Val Gly Leu Ala Ile Ala Tyr Ser Thr Phe Arg Val Gly Arg Lys Gln145 150 155 160ctt cta agc tct gca ttc gtg cca ctc att ggt gaa aaa ggt gca gaa 528Leu Leu Ser Ser Ala Phe Val Pro Leu Ile Gly Glu Lys Gly Ala Glu

165 170 175gga tgg ttg ggc aag ctc atc gac atc ctg gcg att atc gcc acc gta 576Gly Trp Leu Gly Lys Leu Ile Asp Ile Leu Ala Ile Ile Ala Thr Val

180 185 190ttc ggc acg gca tgt tcc ctt ggc ctt ggt gcc ctg cag att ggt gca 624Phe Gly Thr Ala Cys Ser Leu Gly Leu Gly Ala Leu Gln Ile Gly Ala

195 200 205ggc ctg tcc gca gca aac atc att gaa gat cca agc gat tgg acc atc 672Gly Leu Ser Ala Ala Asn Ile Ile Glu Asp Pro Ser Asp Trp Thr Ile

210 215 220gtt ggc att gtt tct gtt ttg acc ctg gca ttt atc ttc tcc gct att 720Val Gly Ile Val Ser Val Leu Thr Leu Ala Phe Ile Phe Ser Ala Ile225 230 235 240tct ggt gtg ggc aag gga atc cag tac ctc tcc aac gcc aac atg gtt 768Ser Gly Val Gly Lys Gly Ile Gln Tyr Leu Ser Asn Ala Asn Met Val

245 250 255ctg gca gct ctg ctc gcg att ttc gtg ttc gtt gtc gga cca acc gtg 816Leu Ala Ala Leu Leu Ala Ile Phe Val Phe Val Val GlyPro Thr Val

260 265 270tcg att ttg aac ctg ctg cca ggt tct att ggc aac tac ctg tcc aac 864Ser Ile Leu Asn Leu Leu Pro Gly Ser Ile Gly Asn Tyr Leu Ser Asn

275 280 285ttc ttt caa atg gca ggc cgc act gcc atg agt gcc gac ggc aca gca 912Phe Phe Gln Met Ala Gly Arg Thr Ala Met Ser Ala Asp Gly Thr Ala

290 295 300ggt gag tgg cta ggt agc tgg acc atc ttc tac tgg gca tgg tgg atc 960Gly Glu Trp Leu Gly Ser Trp Thr Ile Phe Tyr Trp Ala Trp Trp Ile305 310 315 320tct tgg tca cca ttc gta gga atg ttc ttg gca cgt att tcc cgt ggc 1008Ser Trp Ser Pro Phe Val Gly Met Phe Leu Ala Arg Ile Ser Arg Gly

325 330 335cgc tcc atc cgt gag ttc atc ctg ggc gtg ttg ctc gtc cca gca ggt 1056Arg Ser Ile Arg Glu Phe Ile Leu Gly Val Leu Leu Val Pro Ala Gly

340 345 350gtg tcc acc gta tgg ttc tcc att ttt ggt ggc act gcg att gtc ttc 1104Val Ser Thr Val Trp Phe Ser Ile Phe Gly Gly Thr Ala Ile Val Phe

355 360 365gaa caa aat ggg gaa tcc att tgg ggt gat ggt gca gca gaa gag cag 1152Glu Gln Asn Gly Glu Ser Ile Trp Gly Asp Gly Ala Ala Glu Glu Gln

370 375 380ctt ttt gga ttg ctt cat gca ctt cca ggt ggg caa atc atg ggc atc 1200Leu Phe Gly Leu Leu His Ala Leu Pro Gly Gly Gln Ile Met Gly Ile385 390 395 400atc gcc atg att ttg ctg ggt act ttc ttc att acc tct gct gac tct 1248Ile Ala Met Ile Leu Leu Gly Thr Phe Phe Ile Thr Ser Ala Asp Ser

405 410 415gct tcc accgtc atg ggc acc atg agt cag cac ggc cag ctg gaa gcc 1296Ala Ser Thr Val Met Gly Thr Met Ser Gln His Gly Gln Leu Glu Ala

420 425 430aac aag tgg gtg aca gct gcc tgg ggt gtt gct acc gca gct att gga 1344Asn Lys Trp Val Thr Ala Ala Trp Gly Val Ala Thr Ala Ala Ile Gly

435 440 445cta acg cta ttg ctt tct ggt ggt gac aat gcc ttg agc aac ttg caa 1392Leu Thr Leu Leu Leu Ser Gly Gly Asp Asn Ala Leu Ser Asn Leu Gln

450455460 aac gtc acc atc gtg gct gca aca cca ttc ttg ttt gtg gtt att gga 1440Asn Val Thr Ile Val Ala Ala Thr Pro Phe Leu Phe Val Val Ile Gly 465470475480 ttg atg ttt gcg 1452Leu Met Phe Ala<210>452<211>484<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>452Ala Ser Leu Asn Trp Ser Val Ile Val Pro Ala Leu Val Ile Val Leu 151015 Ala Thr Val Val Trp Gly Ile Gly Phe Lys Asp Ser Phe Thr Asn Phe

20 25 30Ala Ser Ser Ala Leu Ser Ala Val Val Asp Asn Leu Gly Trp Ala Phe

35 40 45Ile Leu Phe Gly Thr Val Phe Val Phe Phe Ile Val Val Ile Ala Ala

50 55 60Ser Lys Phe Gly Thr Ile Arg Leu Gly Arg Ile Asp Glu Ala Pro Glu 65 70 75 80Phe Arg Thr Val Ser Trp Ile Ser Met Met Phe Ala Ala Gly Met Gly

85 90 95Ile Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe Tyr Arg

100 105 110Asn Gly Val Pro Gly His Asp Glu His Asn Val Gly Val Ala Met Ser

115 120 125Thr Thr Met Phe His Trp ThrLeu His Pro Trp Ala Ile Tyr Ala Ile

130 135 140Val Gly Leu Ala Ile Ala Tyr Ser Thr Phe Arg Val Gly Arg Lys Gln145 150 155 160Leu Leu Ser Ser Ala Phe Val Pro Leu Ile Gly Glu Lys Gly Ala Glu

165 170 175Gly Trp Leu Gly Lys Leu Ile Asp Ile Leu Ala Ile Ile Ala Thr Val

180 185 190Phe Gly Thr Ala Cys Ser Leu Gly Leu Gly Ala Leu Gln Ile Gly Ala

195 200 205Gly Leu Ser Ala Ala Asn Ile Ile Glu Asp Pro Ser Asp Trp Thr Ile

210 215 220Val Gly Ile Val Ser Val Leu Thr Leu Ala Phe Ile Phe Ser Ala Ile225 230 235 240Ser Gly Val Gly Lys Gly Ile Gln Tyr Leu Ser Asn Ala Asn Met Val

245 250 255Leu Ala Ala Leu Leu Ala Ile Phe Val Phe Val Val Gly Pro Thr Val

260 265 270Ser Ile Leu Asn Leu Leu Pro Gly Ser Ile Gly Asn Tyr Leu Ser Asn

275 280 285Phe Phe Gln Met Ala Gly Arg Thr Ala Met Ser Ala Asp Gly Thr Ala

290 295 300Gly Glu Trp Leu Gly Ser Trp Thr Ile Phe Tyr Trp Ala Trp Trp Ile305 310 315 320Ser Trp Ser Pro Phe Val Gly Met Phe Leu Ala Arg Ile Ser Arg Gly

325 330 335Arg Ser Ile Arg Glu Phe Ile Leu Gly Val Leu Leu Val Pro Ala Gly

340 345 350Val Ser Thr Val Trp Phe Ser Ile Phe Gly Gly Thr Ala Ile Val Phe

355 360 365Glu Gln Asn Gly Glu Ser Ile Trp Gly Asp Gly Ala Ala Glu Glu Gln

370 375 380Leu Phe Gly Leu Leu His Ala Leu Pro Gly Gly Gln Ile Met Gly Ile385 390 395 400Ile Ala Met Ile Leu Leu Gly Thr Phe Phe Ile Thr Ser Ala Asp Ser

405 410 415Ala Ser Thr Val Met Gly Thr Met Ser Gln His Gly Gln Leu Glu Ala

420 425 430Asn Lys Trp Val Thr Ala Ala Trp Gly Val Ala Thr Ala Ala Ile Gly

435 440 445Leu Thr Leu Leu Leu Ser Gly Gly Asp Asn Ala Leu Ser Asn Leu Gln

450455460 Asn Val Thr Ile Val Ala Ala Thr Pro Phe Leu Phe Val Val Ile Gly 465470475480 Leu Met Phe Ala<210>453<211>945<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (945)<223>FRXA01591<400>453gcc tca ctt aac tgg tca gtc atc gtt cca gcc cta gtc att gtc cta 48Ala Ser Leu Asn Trp Ser Val Ile Val Pro Ala Leu Val Ile Val Leu 151015 gcg aca gtg gtg tgg ggt atc gga ttc aaa gat agc ttt acc acc ttt 96Ala Thr Val Val Trp Gly Ile Gly Phe Lys Asp Ser Phe Thr Thr Phe

20 25 30gct agt tct gcg ttg tca gca gta gtt gac aat ctc ggc tgg gcc ttc 144Ala Ser Ser Ala Leu Ser Ala Val Val Asp Asn Leu Gly Trp Ala Phe

35 40 45att ttg ttt ggc aca gtc ttt gta ttt ttt atc gtt gtt atc gcc gct 192Ile Leu Phe Gly Thr Val Phe Val Phe Phe Ile Val Val Ile Ala Ala

50 55 60agt aaa ttc ggc acg att cgc tta ggc cgc att gat gaa gca cca gag 240Ser Lys Phe Gly Thr Ile Arg Leu Gly Arg Ile Asp Glu Ala Pro Glu 65 70 75 80ttt cgc acg gtg tca tgg att tcc atg atg ttt gct gca ggt atg ggt 288Phe Arg Thr Val Ser Trp Ile Ser Met Met Phe Ala Ala Gly Met Gly

85 90 95att ggt ttg atg ttc tac gga acc aca gaa cct tta acc ttc tac cgc 336Ile Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe Tyr Arg

100 105 110aat ggt gta cct gga cat gat gaa cac aat gtt ggc gtt gct atg tcc 384Asn Gly Val Pro Gly His Asp Glu His Asn Val Gly Val Ala Met Ser

115 120 125acg aca atg ttc cac tgg acc ttg cat cca tgg gct atc tac gca att 432Thr Thr Met Phe His Trp Thr Leu His Pro Trp Ala Ile Tyr Ala Ile

130 135 140gtg ggc cta gcc att gcc tat tcg acc ttc cga gtg ggc cgt aaa cag 480Val Gly Leu Ala Ile Ala Tyr Ser Thr Phe Arg Val Gly Arg Lys Gln145 150 155 160ctt cta agc tct gca ttc gtg cca ctc att ggt gaa aaa ggt gca gaa 528Leu Leu Ser Ser Ala Phe Val Pro Leu Ile Gly Glu Lys Gly Ala Glu

165 170 175gga tgg ttg ggc aag ctc atc gac atc ctg gcg att atc gcc acc gta 576Gly Trp Leu Gly Lys Leu Ile Asp Ile Leu Ala Ile Ile Ala Thr Val

180 185 190ttc ggc acg gca tgt tcc ctt ggc ctt ggt gcc ctg cag att ggt gca 624Phe Gly Thr Ala Cys Ser Leu Gly Leu Gly Ala Leu Gln Ile Gly Ala

195 200 205ggc ctg tcc gca gca aac atc att gaa gat cca agc gat tgg acc atc 672Gly Leu Ser Ala Ala Asn Ile Ile Glu Asp Pro Ser Asp Trp Thr Ile

210 215 220gtt ggc att gtt tct gtt ttg acc ctg gca ttt atc ttc tcc gct att 720Val Gly Ile Val Ser Val Leu Thr Leu Ala Phe Ile Phe Ser Ala Ile225 230 235 240tct ggt gtg ggc aag gga atc cag tac ctc tcc aac gcc aac atg gtt 768Ser Gly Val Gly Lys Gly Ile Gln Tyr Leu Ser Asn Ala Asn Met Val

245 250 255ctg gca gct ctg ctc gcg att ttc gtg ttc gtt gtc gga cca acc gtg 816Leu Ala Ala Leu Leu Ala Ile Phe Val Phe Val Val Gly Pro Thr Val

260 265 270tcg att ttg aac ctg ctg cca ggt tct att gtg aac tac ctg tcc aac 864Ser Ile Leu Asn Leu Leu Pro Gly Ser Ile Val Asn Tyr Leu Ser Asn

275 280 285ttc ttt caa atg gta ggc cgc act gcc atg agt gcc gac ggc aca cca 912Phe Phe Gln Met Val Gly Arg Thr Ala Met Ser Ala Asp Gly Thr Pro

290295300 ggt gag tgg ctt ggt ggc tgc acc atc ttc tac 945Gly Glu Trp Leu Gly Gly Cys Thr Ile Phe Tyr 305310315<210>454<211>315<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>454Ala Ser Leu Asn Trp Ser Val Ile Val Pro Ala Leu Val Ile Val Leu 151015 Ala Thr Val Val Trp Gly Ile Gly Phe Lys Asp Ser Phe Thr Thr Phe

20 25 30Ala Ser Ser Ala Leu Ser Ala Val Val Asp Asn Leu Gly Trp Ala Phe

35 40 45Ile Leu Phe Gly Thr Val Phe Val Phe Phe Ile Val Val Ile Ala Ala

50 55 60Ser Lys Phe Gly Thr Ile Arg Leu Gly Arg Ile Asp Glu Ala Pro Glu 65 70 75 80Phe Arg Thr Val Ser Trp Ile Ser Met Met Phe Ala Ala Gly Met Gly

85 90 95Ile Gly Leu Met Phe Tyr Gly Thr Thr Glu Pro Leu Thr Phe Tyr Arg

100 105 110Asn Gly Val Pro Gly His Asp Glu His Asn Val Gly Val Ala Met Ser

115 120 125Thr Thr Met Phe His Trp Thr Leu His Pro Trp Ala Ile Tyr Ala Ile

130 135 140Val Gly Leu Ala Ile Ala Tyr Ser Thr Phe Arg Val Gly Arg Lys Gln145 150 155 160Leu Leu Ser Ser Ala Phe Val Pro Leu Ile Gly Glu Lys Gly Ala Glu

165 170 175Gly Trp Leu Gly Lys Leu Ile Asp Ile Leu Ala Ile Ile Ala Thr Val

180 185 190Phe Gly Thr Ala Cys Ser Leu Gly Leu Gly Ala Leu Gln Ile Gly Ala

195 200 205Gly Leu Ser Ala Ala Asn Ile Ile Glu Asp Pro Ser Asp Trp Thr Ile

210 215 220Val Gly Ile Val Ser Val Leu Thr Leu Ala Phe Ile Phe Ser Ala Ile225 230 235 240Ser Gly Val Gly Lys Gly Ile Gln Tyr Leu Ser Asn Ala Asn Met Val

245 250 255Leu Ala Ala Leu Leu Ala Ile Phe Val Phe Val Val Gly Pro Thr Val

260 265 270Ser Ile Leu Asn Leu Leu Pro Gly Ser Ile Val Asn Tyr Leu Ser Asn

275 280 285Phe Phe Gln Met Val Gly Arg Thr Ala Met Ser Ala Asp Gly Thr Pro

290295300 Gly Glu Trp Leu Gly Gly Cys Thr Ile Phe Tyr 305310315<210>455<211>292<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (292)<223>RXN00201<400>455acgtcgcgga cttcaagtag tcggcgatga aaaagtccgt ttactaaacc ccgatctgtg 60ttacgccatc gcgcggctcg ggcacaccga tacctgggca gtg gca gat tgc gga 115

Val Ala Asp Cys Gly

1 5tta ccc atc cca gaa cac gta gag atc atc gat ttg gca ctc gtg ttt 163Leu Pro Ile Pro Glu His Val Glu Ile Ile Asp Leu Ala Leu Val Phe

10 15 20ggg atc ccc acc ttt gaa caa gta ctg aat gct ctc aag ccg gaa gta 211Gly Ile Pro Thr Phe Glu Gln Val Leu Asn Ala Leu Lys Pro Glu Val

25 30 35gtt gtg gaa ggc gcg gtg att gcc gaa ggg gca ccc caa cgt atc cgc 259Val Val Glu Gly Ala Val Ile Ala Glu Gly Ala Pro Gln Arg Ile Arg

40 45 50gaa atg gtg gat acg gat gtg gaa gta tgt gcg 292Glu Met Val Asp Thr Asp Val Glu Val Cys Ala

5560<210>456<211>64<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>456Val Ala Asp Cys Gly Leu Pro Ile Pro Glu His Val Glu Ile Ile Asp 151015 Leu Ala Leu Val Phe Gly Ile Pro Thr Phe Glu Gln Val Leu Asn Ala

20 25 30Leu Lys Pro Glu Val Val Val Glu Gly Ala Val Ile Ala Glu Gly Ala

35 40 45Pro Gln Arg Ile Arg Glu Met Val Asp Thr Asp Val Glu Val Cys Ala

505560<210>457<211>286<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (286)<223>FRXA00201<400>457acgtcgcgga cttcaagtag tcggcgatga aaaagtccgt ttactaaacc ccgatctgtg 60ttacgccatc gcgcggctcg ggcacaccga tacctgggca gtg gca gat tgc gga 115

Val Ala Asp Cys Gly

1 5tta ccc atc cca gaa cac gta gag atc atc gat ttg gca ctc gtg ttt 163Leu Pro Ile Pro Glu His Val Glu Ile Ile Asp Leu Ala Leu Val Phe

10 15 20ggg atc ccc acc ttt gaa caa gta ctg aat gct ctc aag ccg gaa gta 211Gly Ile Pro Thr Phe Glu Gln Val Leu Asn Ala Leu Lys Pro Glu Val

25 30 35gtt gtg gaa ggc gcg gtg att gcc gaa ggg gca ccc caa cgt atc cgc 259Val Val Glu Gly Ala Val Ile Ala Glu Gly Ala Pro Gln Arg Ile Arg

40 45 50gaa atg gtg gat acg gat gtg gaa gtt 286Glu Met Val Asp Thr Asp Val Glu Val

5560<210>458<211>62<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>458Val Ala Asp Cys Gly Leu Pro Ile Pro Glu His Val Glu Ile Ile Asp 151015 Leu Ala Leu Val Phe Gly Ile Pro Thr Phe Glu Gln Val Leu Asn Ala

20 25 30Leu Lys Pro Glu Val Val Val Glu Gly Ala Val Ile Ala Glu Gly Ala

35 40 45Pro Gln Arg Ile Arg Glu Met Val Asp Thr Asp Val Glu Val

505560<210>459<211>849<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<826)<223>RXA01221<400>459tccagggtgc gatcctggtt ctcgtgatcg tgttgctgcc gggcggaatt gcttcaatta 60aactttccgc gctcaaaaat aaggccagga aggccacctc atg agc ctt aaa atc 115

Met Ser Leu Lys Ile

1 5acc aac ctc aaa gtc gct ttc ggg tcg ttc atc gcc gtg aat gag att 163Thr Asn Leu Lys Val Ala Phe Gly Ser Phe Ile Ala Val Asn Glu Ile

10 15 20agt ttt cag gtg ctg ccc ggt cac gtc cac ttc ctc atc ggt gcc aac 211Ser Phe Gln Val Leu Pro Gly His Val His Phe Leu Ile Gly Ala Asn

25 30 35ggt gca ggt aaa acc acc tgc att gac gcg atc agc gga ttg gcg ccg 259Gly Ala Gly Lys Thr Thr Cys Ile Asp Ala Ile Ser Gly Leu Ala Pro

40 45 50ggg cag gga tca gtg cag ttg gat ggc act gag att ctg gga acc cct 307Gly Gln Gly Ser Val Gln Leu Asp Gly Thr Glu Ile Leu Gly Thr Pro

55 60 65gtg cac cgc att gct cgg atg ggt gtg ggg cga acg ttt cag acc gcc 355Val His Arg Ile Ala Arg Met Gly Val Gly Arg Thr Phe Gln Thr Ala 70 75 80 85agc gtg ttt gaa gaa ttg tct gtg ttg cag aat ctg gat att gcg tgc 403Ser Val Phe Glu Glu Leu Ser Val Leu Gln Asn Leu Asp Ile Ala Cys

90 95 100ggg att cat cgt ccg ttg cgg gcg ctt ctc ggg gtg cgt cat cgg att 451Gly Ile His Arg Pro Leu Arg Ala Leu Leu Gly Val Arg His Arg Ile

105 110 115gat ccc cga att gaa cac gcc ctg gag gtc acg ggt ctt gct gat ctg 499Asp Pro Arg Ile Glu His Ala Leu Glu Val Thr Gly Leu Ala Asp Leu

120 125 130gtg aat gct cag gcg gga acc ttg tcg cat ggg cag aaa cag tgg ctg 547Val Asn Ala Gln Ala Gly Thr Leu Ser His Gly Gln Lys Gln Trp Leu

135 140 145gaa att gca atg ttg ctg gtg cag gat gcg cag gtg ctc atg ctg gat 595Glu Ile Ala Met Leu Leu Val Gln Asp Ala Gln Val Leu Met Leu Asp150 155 160 165gag ccg gtg gcg ggc atg agt gag gag gag cgt gtc gca acg ggt gag 643Glu Pro Val Ala Gly Met Ser Glu Glu Glu Arg Val Ala Thr Gly Glu

170 175 180ctt ttg cag agg gtt gcg cgg gga cgg gtg gtg ttg gtg gtg gag cac 691Leu Leu Gln Arg Val Ala Arg Gly Arg Val Val Leu Val Val Glu His

185 190 195gat atg gag ttc atg cgt cgt ttt gcc act cgc gtc act gtg atg aat 739Asp Met Glu Phe Met Arg Arg Phe Ala Thr Arg Val Thr Val Met Asn

200 205 210cgc ggc acg atc ttg tgt gag ggg tcg gtc gat gag att cag gcg aat 787Arg Gly Thr Ile Leu Cys Glu Gly Ser Val Asp Glu Ile Gln Ala Asn

215220225 ccg gat gtg cag tcc att tat tta ggt acg gca ggg aag tgagttagtc 836Pro Asp Val Gln Ser Ile Tyr Leu Gly Thr Ala Gly Lys 230235240 atgttggaaa tca 849<210>460<211>242<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>460Met Ser Leu Lys Ile Thr Asn Leu Lys Val Ala Phe Gly Ser Phe Ile 151015 Ala Val Asn Glu Ile Ser Phe Gln Val Leu Pro Gly His Val His Phe

20 25 30Leu Ile Gly Ala Asn Gly Ala Gly Lys Thr Thr Cys Ile Asp Ala Ile

35 40 45Ser Gly Leu Ala Pro Gly Gln Gly Ser Val Gln Leu Asp Gly Thr Glu

50 55 60Ile Leu Gly Thr Pro Val His Arg Ile Ala Arg Met Gly Val Gly Arg 65 70 75 80Thr Phe Gln Thr Ala Ser Val Phe Glu Glu Leu Ser Val Leu Gln Asn

85 90 95Leu Asp Ile Ala Cys Gly Ile His Arg Pro Leu Arg Ala Leu Leu Gly

100 105 110Val Arg His Arg Ile Asp Pro Arg Ile Glu His Ala Leu Glu Val Thr

115 120 125Gly Leu Ala Asp Leu Val Asn Ala Gln Ala Gly Thr Leu Ser His Gly

130 135 140Gln Lys Gln Trp Leu Glu Ile Ala Met Leu Leu Val Gln Asp Ala Gln145 150 155 160Val Leu Met Leu Asp Glu Pro Val Ala Gly Met Ser Glu Glu Glu Arg

165 170 175Val Ala Thr Gly Glu Leu Leu Gln Arg Val Ala Arg Gly Arg Val Val

180 185 190Leu Val Val Glu His Asp Met Glu Phe Met Arg Arg Phe Ala Thr Arg

195 200 205Val Thr Val Met Asn Arg Gly Thr Ile Leu Cys Glu Gly Ser Val Asp

210215220 Glu Ile Gln Ala Asn Pro Asp Val Gln Ser Ile Tyr Leu Gly Thr Ala 225230235240 Gly Lys<210>461<211>822<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (799)<223>RXA01222<400>461aatcgcggca cgatcttgtg tgaggggtcg gtcgatgaga ttcaggcgaa tccggatgtg 60cagtccattt atttaggtac ggcagggaag tgagttagtc atg ttg gaa atc act 115

Met Leu Glu Ile Thr

1 5aat ttg tgt gca ggttat ggc cgc acg cag gta ctt cat tct ctt tca 163Asn Leu Cys Ala Gly Tyr Gly Arg Thr Gln Val Leu His Ser Leu Ser

10 15 20atc tcc acg agc agc aac ggc atc ctg tcg atc ctc ggc cac aat ggc 211Ile Ser Thr Ser Ser Asn Gly Ile Leu Ser Ile Leu Gly His Asn Gly

25 30 35gct ggt aaa tcc acc ttg ctg cga acc gcg gtg ggg ttg att aag ccg 259Ala Gly Lys Ser Thr Leu Leu Arg Thr Ala Val Gly Leu Ile Lys Pro

40 45 50act tcc gga gag gtc aaa ctt ttc ggc cag gat gtc acc tcg ttg tcc 307Thr Ser Gly Glu Val Lys Leu Phe Gly Gln Asp Val Thr Ser Leu Ser

55 60 65acg cat gag cga gta aag cgc gga atg gct tat gtg ccg cag ggc cag 355Thr His Glu Arg Val Lys Arg Gly Met Ala Tyr Val Pro Gln Gly Gln 70 75 80 85cag tct ttt acg cag ctt agt tgc atg gaa aat ttg cag gtg gta gcg 403Gln Ser Phe Thr Gln Leu Ser Cys Met Glu Asn Leu Gln Val Val Ala

90 95 100gat ctg cag gga cgt gtg ggc aag gca cgc atc gcg gag gcg ctt gat 451Asp Leu Gln Gly Arg Val Gly Lys Ala Arg Ile Ala Glu Ala Leu Asp

105 110 115cgc ttt ccg gcg ctg acc cag gtg ctg gac cgc caa gcc ggc ctg ttg 499Arg Phe Pro Ala Leu Thr Gln Val Leu Asp Arg Gln Ala Gly Leu Leu

120 125 130tcg ggt ggt cag cgt cag cag ctt gcc atc gcc cgc gcg ctg atc acg 547Ser Gly Gly Gln Arg Gln Gln Leu Ala Ile Ala Arg Ala Leu Ile Thr

135 140 145gcg cca aag ctt ttg ctt ctc gac gaa ccc acc gag ggt att cag cct 595Ala Pro Lys Leu Leu Leu Leu Asp Glu Pro Thr Glu Gly Ile Gln Pro150155 160 165tcg gtg gtt gct gaa att cag cag acc atc atc gat ttg gct aag gac 643Ser Val Val Ala Glu Ile Gln Gln Thr Ile Ile Asp Leu Ala Lys Asp

170 175 180ggc atg agc att gtc ctg gtg gag caa aac att ggt ttt gca ttg gat 691Gly Met Ser Ile Val Leu Val Glu Gln Asn Ile Gly Phe Ala Leu Asp

185 190 195gct gca aca agc tac gcc att gtg gcg cgt ggt cag gtc gtg gaa tcg 739Ala Ala Thr Ser Tyr Ala Ile Val Ala Arg Gly Gln Val Val Glu Ser

200 205 210gga caa ggc gct gaa acc acc gca gag aag cag act aaa gtg cgg gaa 787Gly Gln Gly Ala Glu Thr Thr Ala Glu Lys Gln Thr Lys Val Arg Glu

215220225 tct cta gca atc tagcggctgt ggatagcgtt ttg 822Ser Leu Ala Ile230<210>462<211>233<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>462Met Leu Glu Ile Thr Asn Leu Cys Ala Gly Tyr Gly Arg Thr Gln Val 151015 Leu His Ser Leu Ser Ile Ser Thr Ser Ser Asn Gly Ile Leu Ser Ile

20 25 30Leu Gly His Asn Gly Ala Gly Lys Ser Thr Leu Leu Arg Thr Ala Val

35 40 45Gly Leu Ile Lys Pro Thr Ser Gly Glu Val Lys Leu Phe Gly Gln Asp

50 55 60Val Thr Ser Leu Ser Thr His Glu Arg Val Lys Arg Gly Met Ala Tyr 65 70 75 80Val Pro Gln Gly Gln Gln Ser Phe Thr Gln Leu Ser Cys Met Glu Asn

85 90 95Leu Gln Val Val Ala Asp Leu Gln Gly Arg Val Gly Lys Ala Arg Ile

100 105 110Ala Glu Ala Leu Asp Arg Phe Pro Ala Leu Thr Gln Val Leu Asp Arg

115 120 125Gln Ala Gly Leu Leu Ser Gly Gly Gln Arg Gln Gln Leu Ala Ile Ala

130 135 140Arg Ala Leu Ile Thr Ala Pro Lys Leu Leu Leu Leu Asp Glu Pro Thr145 150 155 160Glu Gly Ile Gln Pro Ser Val Val Ala Glu Ile Gln Gln Thr Ile Ile

165 170 175Asp Leu Ala Lys Asp Gly Met Ser Ile Val Leu Val Glu Gln Asn Ile

180 185 190Gly Phe Ala Leu Asp Ala Ala Thr Ser Tyr Ala Ile Val Ala Arg Gly

195 200 205Gln Val Val Glu Ser Gly Gln Gly Ala Glu Thr Thr Ala Glu Lys Gln

210215220 Thr Lys Val Arg Glu Ser Leu Ala Ile 225230<210>463<211>1005<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (982)<223>RXA01219<400>463caccatttgg gaaaccgatt ccccagttga tccggaccca tacttgtctt cctatgactg 60ggccaagacc accgctgcga cttcctaaga gataaaaatc atg gac att tta ctc 115

Met Asp Ile Leu Leu

1 5aat cag ctc gta gcc ggg ctt tca gtt gga tcg gtc ctt cta ttg gtc 163Asn Gln Leu Val Ala Gly Leu Ser Val Gly Ser Val Leu Leu Leu Val

10 15 20gca gtg gga ttg tca ctg acc ttt gga cag atg ggc gtt att aat atg 211Ala Val Gly Leu Ser Leu Thr Phe Gly Gln Met Gly Val Ile Asn Met

25 30 35gcg cac gga gag ttc atc atg gtc ggc gca tac acc gca tat gtg gtg 259Ala His Gly Glu Phe Ile Met Val Gly Ala Tyr Thr Ala Tyr Val Val

40 45 50cag ctg gtc gtc ggt tct gcc ggt tta tcc cta ctg atc agc att ccg 307Gln Leu Val Val Gly Ser Ala Gly Leu Ser Leu Leu Ile Ser Ile Pro

55 60 65ctg gcc ttt att atc ggt ggg ctt ttc gga gtt ctc ctc gaa caa ttc 355Leu Ala Phe Ile Ile Gly Gly Leu Phe Gly Val Leu Leu Glu Gln Phe 70 75 80 85ctg ctg aag tat ctt tat cac agg cca cta gac acg ctg ctg gcc aca 403Leu Leu Lys Tyr Leu Tyr His Arg Pro Leu Asp Thr Leu Leu Ala Thr

90 95 100ttc ggt gtc ggt ttg atc ctt cag cag ctg gcc cga aac att ttc gga 451Phe Gly Val Gly Leu Ile Leu Gln Gln Leu Ala Arg Asn Ile Phe Gly

105 110 115gct ccc gca gtg gat gtc agg gca ccg gaa ttt ctc cgc gga aac gtc 499Ala Pro Ala Val Asp Val Arg Ala Pro Glu Phe Leu Arg Gly Asn Val

120 125 130gaa gtt cta ggc gtc ttg gtg ccg acc gcg cga cta ttc atc ctg gcg 547Glu Val Leu Gly Val Leu Val Pro Thr Ala Arg Leu Phe Ile Leu Ala

135 140 145ctg gcc atc gca tca gtg act gca cta gct gtg ttc cta aat cgc act 595Leu Ala Ile Ala Ser Val Thr Ala Leu Ala Val Phe Leu Asn Arg Thr150 155 160 165gcc tgg ggc cga cgc atc cgc gcc gtg gtt ctg aac cgc gac ctc gcg 643Ala Trp Gly Arg Arg Ile Arg Ala Val Val Leu Asn Arg Asp Leu Ala

170 175 180gaa acc gca ggt att gat acc cga gct act gac cga atg acg ttc ttt 691Glu Thr Ala Gly Ile Asp Thr Arg Ala Thr Asp Arg Met Thr Phe Phe

185 190 195gtg ggc tcc ggt ctt gcc gga atc gcc ggg gta gct atc aca ttg att 739Val Gly Ser Gly Leu Ala Gly Ile Ala Gly Val Ala Ile Thr Leu Ile

200 205 210ggc gcg acc ggc ccc acc atc ggt cag aac tac atc gtg gat gcc ttc 787Gly Ala Thr Gly Pro Thr Ile Gly Gln Asn Tyr Ile Val Asp Ala Phe

215 220 225ctt gtt gtt gcc gcc ggt ggc atc ggc cgg gtg aag ggc gct gtg atc 835Leu Val Val Ala Ala Gly Gly Ile Gly Arg Val Lys Gly Ala Val Ile230 235 240 245atg gct ttc gtg ctg gga att act caa gca ttc gtg gaa tat acg aca 883Met Ala Phe Val Leu Gly Ile Thr Gln Ala Phe Val Glu Tyr Thr Thr

250 255 260ggt gcg agc atc gcg aag ttc atc gta ctc atc gct gtt gtt gcc ttc 931Gly Ala Ser Ile Ala Lys Phe Ile Val Leu Ile Ala Val Val Ala Phe

265 270 275ctg cag ttt agg cct caa gga ctc ttc caa acc caa act agg agc ctc 979Leu Gln Phe Arg Pro Gln Gly Leu Phe Gln Thr Gln Thr Arg Ser Leu

280285290 gta tgagcactca actcaagctg aag 1005Val<210>464<211>294<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>464Met Asp Ile Leu Leu Asn Gln Leu Val Ala Gly Leu Ser Val Gly Ser 151015 Val Leu Leu Leu Val Ala Val Gly Leu Ser Leu Thr Phe Gly Gln Met

20 25 30Gly Val Ile Asn Met Ala His Gly Glu Phe Ile Met Val Gly Ala Tyr

35 40 45Thr Ala Tyr Val Val Gln Leu Val Val Gly Ser Ala Gly Leu Ser Leu

50 55 60Leu Ile Ser Ile Pro Leu Ala Phe Ile IleGly Gly Leu Phe Gly Val 65 70 75 80Leu Leu Glu Gln Phe Leu Leu Lys Tyr Leu Tyr His Arg Pro Leu Asp

85 90 95Thr Leu Leu Ala Thr Phe Gly Val Gly Leu Ile Leu Gln Gln Leu Ala

100 105 110Arg Asn Ile Phe Gly Ala Pro Ala Val Asp Val Arg Ala Pro Glu Phe

115 120 125Leu Arg Gly Asn Val Glu Val Leu Gly Val Leu Val Pro Thr Ala Arg

130 135 140Leu Phe Ile Leu Ala Leu Ala Ile Ala Ser Val Thr Ala Leu Ala Val145 150 155 160Phe Leu Asn Arg Thr Ala Trp Gly Arg Arg Ile Arg Ala Val Val Leu

165 170 175Asn Arg Asp Leu Ala Glu Thr Ala Gly Ile Asp Thr Arg Ala Thr Asp

180 185 190Arg Met Thr Phe Phe Val Gly Ser Gly Leu Ala Gly Ile Ala Gly Val

195 200 205Ala Ile Thr Leu Ile Gly Ala Thr Gly Pro Thr Ile Gly Gln Asn Tyr

210 2l5 220Ile Val Asp Ala Phe Leu Val Val Ala Ala Gly Gly Ile Gly Arg Val225 230 235 240Lys Gly Ala Val Ile Met Ala Phe Val Leu Gly Ile Thr Gln Ala Phe

245 250 255Val Glu Tyr Thr Thr Gly Ala Ser Ile Ala Lys Phe Ile Val Leu Ile

260 265 270Ala Val Val Ala Phe Leu Gln Phe Arg Pro Gln Gly Leu Phe Gln Thr

275 280 285Gln Thr Arg Ser Leu Val

290<210>465<211>1200<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1177)<223>RXA01220<400>465caggtgcgag catcgcgaag ttcatcgtac tcatcgctgt tgttgccttc ctgcagttta 60ggcctcaagg actcttccaa acccaaacta ggagcctcgt atg agc act caa ctc 115

Met Ser Thr Gln Leu

1 5aag ctg aag aag ccc gca aag aag aaa act acg ccg aaa ctt agc gtc 163Lys Leu Lys Lys Pro Ala Lys Lys Lys Thr Thr Pro Lys Leu Ser Val

10 15 20gta aat gct ccc acg ctg cgc act gcg gcg ttg ggc ctg gcc gcg ctc 211Val Asn Ala Pro Thr Leu Arg Thr Ala Ala Leu Gly Leu Ala Ala Leu

25 30 35gct gcg gta ttg ctg tgc gcc ccg ctc ttt tta tcc aca ttc cag ctg 259Ala Ala Val Leu Leu Cys Ala Pro Leu Phe Leu Ser Thr Phe Gln Leu

40 45 50acg ttg atg tcg cgc ttg gtg tgt tat gcg atc gtc gca gtc ggc atc 307Thr Leu Met Ser Arg Leu Val Cys Tyr Ala Ile Val Ala Val Gly Ile

55 60 65ggg ctg gcg tgg ggc aga ggc ggc atg ctc acg ctg ggg caa ggc gtg 355Gly Leu Ala Trp Gly Arg Gly Gly Met Leu Thr Leu Gly Gln Gly Val 70 75 80 85ttc ttt gga atc ggc gcg tac atc atg gcc atg cac atg ctg tac agc 403Phe Phe Gly Ile Gly Ala Tyr Ile Met Ala Met His Met Leu Tyr Ser

90 95 100gat tcg cag att ttt ggg acc aca gtt ccg caa tgg tgg tcc att ttt 451Asp Ser Gln Ile Phe Gly Thr Thr Val Pro Gln Trp Trp Ser Ile Phe

105 110 115gcc aac ccg gca gtc gca ctc atc gca gtt gtg gcg ctt ccc ggc atc 499Ala Asn Pro Ala Val Ala Leu Ile Ala Val Val Ala Leu Pro Gly Ile

120 125 130gtg gct ttt gtg ctc ggc ttc tcc att ttc aaa cga cgc atc aaa ggc 547Val Ala Phe Val Leu Gly Phe Ser Ile Phe Lys Arg Arg Ile Lys Gly

135 140 145gcc tac ttt gcc atc gtg aac caa gcg ctc gcc gca gct gtt gtg gtg 595Ala Tyr Phe Ala Ile Val Asn Gln Ala Leu Ala Ala Ala Val Val Val150 155 160 165ttg ctg gtc gga caa caa gat tcc ctt gga ggt tcc aat ggt ctt tcc 643Leu Leu Val Gly Gln Gln Asp Ser Leu Gly Gly Ser Asn Gly Leu Ser

170 175 180gga ttt cga tcg ttc atg ggt ttt gcc gtc tac gac ccc atc aac cgc 691Gly Phe Arg Ser Phe Met Gly Phe Ala Val Tyr Asp Pro Ile Asn Arg

185 190 195atc atg ttt tac ttc acc gca gtg gga gtt ctc ttg gct ttg gtg gct 739Ile Met Phe Tyr Phe Thr Ala Val Gly Val Leu Leu Ala Leu Val Ala

200 205 210atc tca tat tgg ctc atg cgc agc cgc tat gga gaa ctg ctc gtg gcc 787Ile Ser Tyr Trp Leu Met Arg Ser Arg Tyr Gly Glu Leu Leu Val Ala

215 220 225acc aga gat gca gaa gaa cgc gtc cga ttc ctc gga tat gat ccc gca 835Thr Arg Asp Ala Glu Glu Arg Val Arg Phe Leu Gly Tyr Asp Pro Ala230 235 240 245ttg atc aaa acc gcc gca tat gtc att gct gcg atg att gcc gga atc 883Leu Ile Lys Thr Ala Ala Tyr Val Ile Ala Ala Met Ile Ala Gly Ile

250 255 260gcc gga gcg ctg ttc gtg ccg atc gtg ggc atc att tca ccc gca gaa 931Ala Gly Ala Leu Phe Val Pro Ile Val Gly Ile Ile SerPro Ala Glu

265 270 275atc ggc gtg gtg cca tca atc gtg ttc gtg atc gcc gtc gcc gct ggt 979Ile Gly Val Val Pro Ser Ile Val Phe Val Ile Ala Val Ala Ala Gly

280 285 290ggc agg gca tcc cta ttc ggt ccc gta gtt ggc gcg ctg gtg ctg ggc 1027Gly Arg Ala Ser Leu Phe Gly Pro Val Val Gly Ala Leu Val Leu Gly

295 300 305tgg gtg gaa tcc aca ctt gct caa act ttc ccc agc atg tgg tcc tat 1075Trp Val Glu Ser Thr Leu Ala Gln Thr Phe Pro Ser Met Trp Ser Tyr310 315 320 325ttc cag ggt gcg atc ctg gtt ctc gtg atc gtg ttg ctg ccg ggc gga 1123Phe Gln Gly Ala Ile Leu Val Leu Val Ile Val Leu Leu Pro Gly Gly

330 335 340att gct tca att aaa ctt tcc gcg ctc aaa aat aag gcc agg aag gcc 1171Ile Ala Ser Ile Lys Leu Ser Ala Leu Lys Asn Lys Ala Arg Lys Ala

345350355 acc tca tgagccttaa aatcaccaac ctc 1200Thr Ser<210>466<211>359<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>466Met Ser Thr Gln Leu Lys Leu Lys Lys Pro Ala Lys Lys Lys Thr Thr 151015 Pro Lys Leu Ser Val Val Asn Ala Pro Thr Leu Arg Thr Ala Ala Leu

20 25 30Gly Leu Ala Ala Leu Ala Ala Val Leu Leu Cys Ala Pro Leu Phe Leu

35 40 45Ser Thr Phe Gln Leu Thr Leu Met Ser Arg Leu Val Cys Tyr Ala Ile

50 55 60Val Ala Val Gly Ile Gly Leu Ala Trp Gly Arg Gly Gly Met Leu Thr 65 70 75 80Leu Gly Gln Gly Val Phe Phe Gly Ile Gly Ala Tyr Ile Met Ala Met

85 90 95His Met Leu Tyr Ser Asp Ser Gln Ile Phe Gly Thr Thr Val Pro Gln

100 105 110Trp Trp Ser Ile Phe Ala Asn Pro Ala Val Ala Leu Ile Ala Val Val

115 120 125Ala Leu Pro Gly Ile Val Ala Phe Val Leu Gly Phe Ser Ile Phe Lys

130 135 140Arg Arg Ile Lys Gly Ala Tyr Phe Ala Ile Val Asn Gln Ala Leu Ala145 150 155 160Ala Ala Val Val Val Leu Leu Val Gly Gln Gln Asp Ser Leu Gly Gly

165 170 175Ser Asn Gly Leu Ser Gly Phe Arg Ser Phe Met Gly Phe Ala Val Tyr

180 185 190Asp Pro Ile Asn Arg Ile Met Phe Tyr Phe Thr Ala Val Gly Val Leu

195 200 205Leu Ala Leu Val Ala Ile Ser Tyr Trp Leu Met Arg Ser Arg Tyr Gly

210 215 220Glu Leu Leu Val Ala Thr Arg Asp Ala Glu Glu Arg Val Arg Phe Leu225 230 235 240Gly Tyr Asp Pro Ala Leu Ile Lys Thr Ala Ala Tyr Val Ile Ala Ala

245 250 255Met Ile Ala Gly Ile Ala Gly Ala Leu Phe Val Pro Ile Val Gly Ile

260 265 270Ile Ser Pro Ala Glu Ile Gly Val Val Pro Ser Ile Val Phe Val Ile

275 280 285Ala Val Ala Ala Gly Gly Arg Ala Ser Leu Phe Gly Pro Val Val Gly

290 295 300Ala Leu Val Leu Gly Trp Val Glu Ser Thr Leu Ala Gln Thr Phe Pro305 310 315320Ser Met Trp Ser Tyr Phe Gln Gly Ala Ile Leu Val Leu Val Ile Val

325 330 335Leu Leu Pro Gly Gly Ile Ala Ser Ile Lys Leu Ser Ala Leu Lys Asn

340 345 350Lys Ala Arg Lys Ala Thr Ser

355<210>467<211>876<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (853)<223>RXA00091<400>467tcatgaacca cgtgttccgc gcacaaggcg tcgtgtccat cattattgag atggtcggcg 60gtaccgtctt cctcatcgtc atcctcagaa agggcagact gtg att acg tta act 115

Val Ile Thr Leu Thr

1 5aat gtc cgc aag gaa tac tcc agc gac gtt gcc atc ggc ccc gtc aac 163Asn Val Arg Lys Glu Tyr Ser Ser Asp Val Ala Ile Gly Pro Val Asn

10 15 20ctt gag atc cca gcc ggc ggc atc acc gcg ttg gtc ggc cca aac ggt 211Leu Glu Ile Pro Ala Gly Gly Ile Thr Ala Leu Val Gly Pro Asn Gly

25 30 35gca ggc aag tca aca ctg ctc acc atg atc ggt cga ctc ctc ggc atc 259Ala Gly Lys Ser Thr Leu Leu Thr Met Ile Gly Arg Leu Leu Gly Ile

40 45 50gat gaa ggc aac atc acc gta gcc tcc tac gat gtc acc tca acc gca 307Asp Glu Gly Asn Ile Thr Val Ala Ser Tyr Asp Val Thr Ser Thr Ala

55 60 65tcc aaa gat ctg gcc aag atc atc tcc atc ctg cgc cag gaa aac cac 355Ser Lys Asp Leu Ala Lys Ile Ile Ser Ile Leu Arg Gln Glu Asn His 70 75 80 85ttt gtt acc aag ctg acc gtg cgc cag ctc gtaggt ttc gga cgc ttc 403Phe Val Thr Lys Leu Thr Val Arg Gln Leu Val Gly Phe Gly Arg Phe

90 95 100cca tat agc aag ggc cgg ctg acg gaa gaa gac gag gga atc atc tcc 451Pro Tyr Ser Lys Gly Arg Leu Thr Glu Glu Asp Glu Gly Ile Ile Ser

105 110 115cgc tac atc gac ttc ttc aat ctc acc gaa ctc gaa gac cgc tac ctc 499Arg Tyr Ile Asp Phe Phe Asn Leu Thr Glu Leu Glu Asp Arg Tyr Leu

120 125 130gac cag ctt tcc ggc ggc cag cgc cag cgc gcc tat gtc gcc atg gtg 547Asp Gln Leu Ser Gly Gly Gln Arg Gln Arg Ala Tyr Val Ala Met Val

135 140 145ctg tgc caa gag acg gac tac gtg ctt ctc gac gaa ccc ctc aac aat 595Leu Cys Gln Glu Thr Asp Tyr Val Leu Leu Asp Glu Pro Leu Asn Asn150 155 160 165ctt gat atc gca cac tcg gtg gaa atg atg aaa cac ctc gag aat gct 643Leu Asp Ile Ala His Ser Val Glu Met Met Lys His Leu Glu Asn Ala

170 175 180gca gcc caa ttt ggc cgc acc atc atc gtg gtt ctt cac gac atc aac 691Ala Ala Gln Phe Gly Arg Thr Ile Ile Val Val Leu His Asp Ile Asn

185 190 195ttc gcc gcg cgc tac gcc gat tac atc gtg gcc gta aag cac gga atg 739Phe Ala Ala Arg Tyr Ala Asp Tyr Ile Val Ala Val Lys His Gly Met

200 205 210atc gaa aaa gag gga aca cct gaa cag atc atg aaa aac gag atc ctt 787Ile Glu Lys Glu Gly Thr Pro Glu Gln Ile Met Lys Asn Glu Ile Leu

215 220 225tca gaa atc ttc aat aca gag atc gaa gtt att gaa gga cca cac ggc 835Ser Glu Ile Phe Asn Thr Glu Ile Glu Val Ile Glu Gly Pro His Gly230235 240 245aag att gct tgc tac cac taaatgaaga gaaataagcc gac 876Lys Ile Ala Cys Tyr His

250<210>468<211>251<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>468Val Ile Thr Leu Thr Asn Val Arg Lys Glu Tyr Ser Ser Asp Val Ala 151015 Ile Gly Pro Val Asn Leu Glu Ile Pro Ala Gly Gly Ile Thr Ala Leu

20 25 30Val Gly Pro Asn Gly Ala Gly Lys Ser Thr Leu Leu Thr Met Ile Gly

35 40 45Arg Leu Leu Gly Ile Asp Glu Gly Asn Ile Thr Val Ala Ser Tyr Asp

50 55 60Val Thr Ser Thr Ala Ser Lys Asp Leu Ala Lys Ile Ile Ser Ile Leu 65 70 75 80Arg Gln Glu Asn His Phe Val Thr Lys Leu Thr Val Arg Gln Leu Val

85 90 95Gly Phe Gly Arg Phe Pro Tyr Ser Lys Gly Arg Leu Thr Glu Glu Asp

100 105 110Glu Gly Ile Ile Ser Arg Tyr Ile Asp Phe Phe Asn Leu Thr Glu Leu

115 120 125Glu Asp Arg Tyr Leu Asp Gln Leu Ser Gly Gly Gln Arg Gln Arg Ala

130 135 140Tyr Val Ala Met Val Leu Cys Gln Glu Thr Asp Tyr Val Leu Leu Asp145 150 155 160Glu Pro Leu Asn Asn Leu Asp Ile Ala His Ser Val Glu Met Met Lys

165 170 175His Leu Glu Asn Ala Ala Ala Gln Phe Gly Arg Thr Ile Ile Val Val

180 185 190Leu His Asp Ile Asn Phe Ala Ala Arg Tyr Ala Asp Tyr Ile Val Ala

195 200 205Val Lys His Gly Met Ile Glu Lys Glu Gly Thr Pro Glu Gln Ile Met

210 215 220Lys Asn Glu Ile Leu Ser Glu Ile Phe Asn Thr Glu Ile Glu Val Ile225 230 235 240Glu Gly Pro His Gly Lys Ile Ala Cys Tyr His

245250<210>469<211>692<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(79) } (669)<223>RXA00228<400>469ccgcatggca tccgccgaaa gaattcccct ccggaggaat ggcacgcctc atgggagaac 60gcatcggcaa aaactgac atg cgc gac ctc cgc tcc atg atc ggc gtc agc 111

Met Arg Asp Leu Arg Ser Met Ile Gly Val Ser

1 5 10tcc tcc gca tta ggc aac cga atc ccc tcc gaa gaa aaa gtc tct gac 159Ser Ser Ala Leu Gly Asn Arg Ile Pro Ser Glu Glu Lys Val Ser Asp

15 20 25cta gtc atc tcc gca ggc tac gca atc ctc ggc cgc tgg cgc gaa gac 207Leu Val Ile Ser Ala Gly Tyr Ala Ile Leu Gly Arg Trp Arg Glu Asp

30 35 40tac gac gaa atg gac ttc gga caa gcc acc gaa atc ctc gaa caa gtc 255Tyr Asp Glu Met Asp Phe Gly Gln Ala Thr Glu Ile Leu Glu Gln Val

45 50 55gga gcc atg cac cta gcc gac cgc acc tgg gga acc ctc tcc gaa ggc 303Gly Ala Met His Leu Ala Asp Arg Thr Trp Gly Thr Leu Ser Glu Gly 60 65 70 75gaa cgc aaa cga gtc ctg gtc gca cgc gca ctc atg acc aac ccg gaa 351Glu Arg Lys Arg Val Leu Val Ala Arg Ala Leu Met Thr Asn Pro Glu

80 8590ctc ctc atc ctt gac gaa cca acc gca gga atg gac ctc ggc gga cgc 399Leu Leu Ile Leu Asp Glu Pro Thr Ala Gly Met Asp Leu Gly Gly Arg

95 100 105gaa gac ctc gtc ggc tac ctc gga gaa ctc gcc atg gac cca gac gca 447Glu Asp Leu Val Gly Tyr Leu Gly Glu Leu Ala Met Asp Pro Asp Ala

110 115 120cct gcc atc gtc atg atc acc cac cac gtc gaa gaa atc ccc gcc gga 495Pro Ala Ile Val Met Ile Thr His His Val Glu Glu Ile Pro Ala Gly

125 130 135ttc acc cac gca atg ctc ctc gac gaa ggt gaa atc gta gcc caa ggc 543Phe Thr His Ala Met Leu Leu Asp Glu Gly Glu Ile Val Ala Gln Gly140 145 150 155ctg atc aac acc gtc atg aca aac gag aac cta tcc aaa gca ttc cac 591Leu Ile Asn Thr Val Met Thr Asn Glu Asn Leu Ser Lys Ala Phe His

160 165 170cag cca atc caa gta gac cgc atc ggg gaa cgc tac ttt gcc cgc cgt 639Gln Pro Ile Gln Val Asp Arg Ile Gly Glu Arg Tyr Phe Ala Arg Arg

175 180 185gtg aga acc gcc agg agt cat agg gct cag taggtttttt ggagttgtgg 689Val Arg Thr Ala Arg Ser His Arg Ala Gln

190195 gcc 692<210>470<211>197<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>470Met Arg Asp Leu Arg Ser Met Ile Gly Val Ser Ser Ser Ala Leu Gly 151015 Asn Arg Ile Pro Ser Glu Glu Lys Val Ser Asp Leu Val Ile Ser Ala

20 25 30Gly Tyr Ala Ile Leu Gly Arg Trp Arg Glu Asp Tyr Asp Glu Met Asp

35 40 45Phe Gly Gln Ala Thr Glu Ile Leu Glu Gln Val Gly Ala Met His Leu

50 55 60Ala Asp Arg Thr Trp Gly Thr Leu Ser Glu Gly Glu Arg Lys Arg Val 65 70 75 80Leu Val Ala Arg Ala Leu Met Thr Asn Pro Glu Leu Leu Ile Leu Asp

85 90 95Glu Pro Thr Ala Gly Met Asp Leu Gly Gly Arg Glu Asp Leu Val Gly

100 105 110Tyr Leu Gly Glu Leu Ala Met Asp Pro Asp Ala Pro Ala Ile Val Met

115 120 125Ile Thr His His Val Glu Glu Ile Pro Ala Gly Phe Thr His Ala Met

130 135 140Leu Leu Asp Glu Gly Glu Ile Val Ala Gln Gly Leu Ile Asn Thr Val145 150 155 160Met Thr Asn Glu Asn Leu Ser Lys Ala Phe His Gln Pro Ile Gln Val

165 170 175Asp Arg Ile Gly Glu Arg Tyr Phe Ala Arg Arg Val Arg Thr Ala Arg

180 185 190Ser His Arg Ala Gln

195<210>471<211>813<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (790)<223>RXA00346<400>471atctatgaga cccctcaaaa caccgagaat ttcctcgatg cattcaccaa ggcagttgat 60gatctcaccg ctgccactaa ccaggtttag aattatttaa atg ctg ttg act ttc 115

Met Leu Leu Thr Phe

1 5aat gat gct gcg gtg gat ccc ctc tgg agg ggc ctg aat tta gag ctc 163Asn Asp Ala Ala Val Asp Pro Leu Trp Arg Gly Leu Asn Leu Glu Leu

10 15 20cga cag ggg gaa ttt ctt gcg gtt tta ggc ccc aac ggc gtg gga aaa 211Arg Gln Gly Glu Phe Leu Ala Val Leu Gly Pro Asn Gly Val Gly Lys

25 30 35tcc acg ctc atc ggt acg att ttg ggc acc cga aaa ctc acc cac ggt 259Ser Thr Leu Ile Gly Thr Ile Leu Gly Thr Arg Lys Leu Thr His Gly

40 45 50tcg gtt aaa act gat gcc cgg gtg ggt tat att ccg caa caa cga att 307Ser Val Lys Thr Asp Ala Arg Val Gly Tyr Ile Pro Gln Gln Arg Ile

55 60 65ttc gat gtc ccg ttg cgt gcc cgc gat atg gtt tcg ctg tcc gcg gcg 355Phe Asp Val Pro Leu Arg Ala Arg Asp Met Val Ser Leu Ser Ala Ala 70 75 80 85cat ggc gtg gtt tcc aaa agg gga ccc gcg aag ggt gac gtc gat aag 403His Gly Val Val Ser Lys Arg Gly Pro Ala Lys Gly Asp Val Asp Lys

90 95 100ctt ctt gcc cgc gtg ggc gct tcc gga atc gcc gat cga cgc gtc ggc 451Leu Leu Ala Arg Val Gly Ala Ser Gly Ile Ala Asp Arg Arg Val Gly

105 110 115gag ctc tcc ggc ggg cag cag cag ctc gtc cgc caa gcc cag gcc ctt 499Glu Leu Ser Gly Gly Gln Gln Gln Leu Val Arg Gln Ala Gln Ala Leu

120 125 130gcc acg cgc ccg caa tta ttg ctt gcc gac gaa ccc ctc ctc agc ctt 547Ala Thr Arg Pro Gln Leu Leu Leu Ala Asp Glu Pro Leu Leu Ser Leu

135 140 145gac ccc ggc gtc gcg cag cgc acg gtg tcc cta ttt ggt gaa ttg aag 595Asp Pro Gly Val Ala Gln Arg Thr Val Ser Leu Phe Gly Glu Leu Lys150 155 160 165gcc gaa ggc gtc ggc gtt gtt gtg gtc acc cac gat gtc aat cca cta 643Ala Glu Gly Val Gly Val Val Val Val Thr His Asp Val Asn Pro Leu

170 175 180atg ggc ctg gta gat cgc att ttg tac ctc gcc ccc aac ggc cac acc 691Met Gly Leu Val Asp Arg Ile Leu Tyr Leu Ala Pro Asn Gly His Thr

185 190 195atc ggc acg gtt ggc gat gtc atg cag tcc gaa aaa ctc agc gaa ctc 739Ile Gly Thr Val Gly Asp Val Met Gln Ser Glu Lys Leu Ser Glu Leu

200 205 210tac aac gca ccc gtc acg gtg gct cgc atc aac gac aga atc gtg gtg 787Tyr Asn Ala Pro Val Thr Val Ala Arg Ile Asn Asp Arg Ile Val Val

215220225 gtt taagtggatc tatccacctg gct 813Val230<210>472<211>230<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>472Met Leu Leu Thr Phe Asn Asp Ala Ala Val Asp Pro Leu Trp Arg Gly 151015 Leu Asn Leu Glu Leu Arg Gln Gly Glu Phe Leu Ala Val Leu Gly Pro

20 25 30Asn Gly Val Gly Lys Ser Thr Leu Ile Gly Thr Ile Leu Gly Thr Arg

35 40 45Lys Leu Thr His Gly Ser Val Lys Thr Asp Ala Arg Val Gly Tyr Ile

50 55 60Pro Gln Gln Arg Ile Phe Asp Val Pro Leu Arg Ala Arg Asp Met Val 65 70 75 80Ser Leu Ser Ala Ala His Gly Val Val Ser Lys Arg Gly Pro Ala Lys

85 90 95Gly Asp Val Asp Lys Leu Leu Ala Arg Val Gly Ala Ser Gly Ile Ala

100 105 110Asp Arg Arg Val Gly Glu Leu Ser Gly Gly Gln Gln Gln Leu Val Arg

115 120 125Gln Ala Gln Ala Leu Ala Thr Arg Pro Gln Leu Leu Leu Ala Asp Glu

130 135 140Pro Leu Leu Ser Leu Asp Pro Gly Val Ala Gln Arg Thr Val Ser Leu145 150 155 160Phe Gly Glu Leu Lys Ala Glu Gly Val Gly Val Val Val Val Thr His

165 170 175Asp Val Asn Pro Leu Met Gly Leu Val Asp Arg Ile Leu Tyr Leu Ala

180 185 190Pro Asn Gly His Thr Ile Gly Thr Val Gly Asp Val Met Gln Ser Glu

195 200 205Lys Leu Ser Glu Leu Tyr Asn Ala Pro Val Thr Val Ala Arg Ile Asn

210215220 Asp Arg Ile Val Val Val 225230<210>473<211>433<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).)

Val Thr Thr Asn His

1 5caa cta tcc gcc gaa gaa att tcc ctg gcg tac ggc gag cgc acc atc 163Gln Leu Ser Ala Glu Glu Ile Ser Leu Ala Tyr Gly Glu Arg Thr Ile

10 15 20atc gat tcg ctc agc gtc gac atc gtc ccc ggc aaa atc acc tcc atc 211Ile Asp Ser Leu Ser Val Asp Ile Val Pro Gly Lys Ile Thr Ser Ile

25 30 35gtc ggc ccc aac gga tgc ggc aaa tca acg ctg ctg cgc gcc ttt gcg 259Val Gly Pro Asn Gly Cys Gly Lys Ser Thr Leu Leu Arg Ala Phe Ala

40 45 50cgc ctc ctt aaa cct agc gcc ggg caa gcg ctt atc gac gcc cac ccc 307Arg Leu Leu Lys Pro Ser Ala Gly Gln Ala Leu Ile Asp Ala His Pro

55 60 65ctt cct tca ctg cca ggc aaa gaa cta gct cgc atg ctc ggg ctg tta 355Leu Pro Ser Leu Pro Gly Lys Glu Leu Ala Arg Met Leu Gly Leu Leu 70 75 80 85ccg caa tcc ccc acc gga cct gaa ggc atc gtc gtc gcc gac ctc gtg 403Pro Gln Ser Pro Thr Gly Pro Glu Gly Ile Val Val Ala Asp Leu Val

90 95 100ggc cgc ggc cgc cac ccc cac caa gga ctc 433Gly Arg Gly Arg His Pro His Gln Gly Leu

105110<210>474<211>111<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>474Val Thr Thr Asn His Gln Leu Ser Ala Glu Glu Ile Ser Leu Ala Tyr 151015 Gly Glu Arg Thr Ile Ile As p Ser Leu Ser Val Asp Ile Val Pro Gly

20 25 30Lys Ile Thr Ser Ile Val Gly Pro Asn Gly Cys Gly Lys Ser Thr Leu

35 40 45Leu Arg Ala Phe Ala Arg Leu Leu Lys Pro Ser Ala Gly Gln Ala Leu

50 55 60Ile Asp Ala His Pro Leu Pro Ser Leu Pro Gly Lys Glu Leu Ala Arg 65 70 75 80Met Leu Gly Leu Leu Pro Gln Ser Pro Thr Gly Pro Glu Gly Ile Val

85 90 95Val Ala Asp Leu Val Gly Arg Gly Arg His Pro His Gln Gly Leu

100105110<210>475<211>900<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (877)<223>RXA01823<400>475gcaacacgtt gatactgagc tgcacacgcc cgttggcctg gtgaccagtt tgctgggcgg 60ggtgtatttg atgtggcttt tgagccgaaa ggaggcataa atg ctg caa gcg cat 115

Met Leu Gln Ala His

1 5gat ctc acg ctg agt tac ggc ggg cga aat att gta gaa ggg ctc agt 163Asp Leu Thr Leu Ser Tyr Gly Gly Arg Asn Ile Val Glu Gly Leu Ser

10 15 20ctg gac ctt ccg gaa aga ggc ctc agc atc atc att ggc ccc aac gga 211Leu Asp Leu Pro Glu Arg Gly Leu Ser Ile Ile Ile Gly Pro Asn Gly

25 30 35tgc ggg aaa tca acc gtt ttg aaa gcg ttg ggc aga ctg ctg aaa cca 259Cys Gly Lys Ser Thr Val Leu Lys Ala Leu Gly Arg Leu Leu Lys Pro

40 45 50caa ttg ggg aag atc acg cta ggt ggg cga gat att tcc agc atg ggc 307Gln Leu Gly Lys Ile Thr Leu Gly Gly Arg Asp Ile Ser Ser Met Gly

55 60 65acc aag cat gtg gcg aaa cac atc ggg gtg ctt ccg caa ccc cca tat 355Thr Lys His Val Ala Lys His Ile Gly Val Leu Pro Gln Pro Pro Tyr 70 75 80 85gcg ccc gat ggg gtg agc gtc acg gag ctg gtc agc cgc ggg cgg tat 403Ala Pro Asp Gly Val Ser Val Thr Glu Leu Val Ser Arg Gly Arg Tyr

90 95 100ccg cac caa cat ctg ctg tcg caa tgg tcg aaa gac gat gaa gcc att 451Pro His Gln His Leu Leu Ser Gln Trp Ser Lys Asp Asp Glu Ala Ile

105 110 115gtg gcg cgc tcg ctg gcg gaa gtc ggc atg cac acc cat gct gag cat 499Val Ala Arg Ser Leu Ala Glu Val Gly Met His Thr His Ala Glu His

120 125 130tta gtg tcg gaa ctt tca ggc ggc cag cgc caa cgg gcg tgg atc gcc 547Leu Val Ser Glu Leu Ser Gly Gly Gln Arg Gln Arg Ala Trp Ile Ala

135 140 145atg gcg ctc gct cag gaa aca gac att ttg ctt ctc gac gag ccc acc 595Met Ala Leu Ala Gln Glu Thr Asp Ile Leu Leu Leu Asp Glu Pro Thr150 155 160 165acg ttc ctc gac gta gcc cac caa ata tcc gtc ctc gat tta tgc tcc 643Thr Phe Leu Asp Val Ala His Gln Ile Ser Val Leu Asp Leu Cys Ser

170 175 180gac ctg cac caa cgt ggt cgc acc ctg gcc att gtt cta cac gat ctg 691Asp Leu His Gln Arg Gly Arg Thr Leu Ala Ile Val Leu His Asp Leu

185 190 195aac atg gct gca cgg tat gcc acc cac atc arc gcc atg cgg gac ggc 739Asn Met Ala Ala Arg Tyr Ala Thr His Ile Ile Ala Met Arg Asp Gly

200 205 210acc atc atc gac caa gga aaa ccc gaa gaa ata ctc act aaa gcg ctg 787Thr Ile Ile Asp Gln Gly Lys Pro Glu Glu Ile Leu Thr Lys Ala Leu

215 220 225ctc aaa gaa gtt ttt gac ctc gac gca ctc atc ctc aaa gac ccc aac 835Leu Lys Glu Val Phe Asp Leu Asp Ala Leu Ile Leu Lys Asp Pro Asn230 235 240 245aac ggc cga cca ctc atc gtg ccc aca gac agg aga aac tca 877Asn Gly Arg Pro Leu Ile Val Pro Thr Asp Arg Arg Asn Ser

250255 tgaaagaaac cgacaaccta ctg 900<210>476<211>259<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>476Met Leu Gln Ala His Asp Leu Thr Leu Ser Tyr Gly Gly Arg Asn Ile 151015 Val Glu Gly Leu Ser Leu Asp Leu Pro Glu Arg Gly Leu Ser Ile Ile

20 25 30Ile Gly Pro Asn Gly Cys Gly Lys Ser Thr Val Leu Lys Ala Leu Gly

35 40 45Arg Leu Leu Lys Pro Gln Leu Gly Lys Ile Thr Leu Gly Gly Arg Asp

5055 60Ile Ser Ser Met Gly Thr Lys His Val Ala Lys His Ile Gly Val Leu 65 70 75 80Pro Gln Pro Pro Tyr Ala Pro Asp Gly Val Ser Val Thr Glu Leu Val

85 90 95Ser Arg Gly Arg Tyr Pro His Gln His Leu Leu Ser Gln Trp Ser Lys

100 105 110Asp Asp Glu Ala Ile Val Ala Arg Ser Leu Ala Glu Val Gly Met His

115 120 125Thr His Ala Glu His Leu Val Ser Glu Leu Ser Gly Gly Gln Arg Gln

130 135 140Arg Ala Trp Ile Ala Met Ala Leu Ala Gln Glu Thr Asp Ile Leu Leu145 150 155 160Leu Asp Glu Pro Thr Thr Phe Leu Asp Val Ala His Gln Ile Ser Val

165 170 175Leu Asp Leu Cys Ser Asp Leu His Gln Arg Gly Arg Thr Leu Ala Ile

180 185 190Val Leu His Asp Leu Asn Met Ala Ala Arg Tyr Ala Thr His Ile Ile

195 200 205Ala Met Arg Asp Gly Thr Ile Ile Asp Gln Gly Lys Pro Glu Glu Ile

210 215 220Leu Thr Lys Ala Leu Leu Lys Glu Val Phe Asp Leu Asp Ala Leu Ile225 230 235 240Leu Lys Asp Pro Asn Asn Gly Arg Pro Leu Ile Val Pro Thr Asp Arg

245250255 Arg Asn Ser<210>477<211>906<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (883)<223>RXA02767<400>477gggaaaacgt ttcctcgccg cccacagaat cataaaaatt ttctgaggtt gtcatgggta 60ccagtctaag ccctggcctt acgccagtaa ggtgttaccc atg cgc gaa cta gca 115

Met Arg Glu Leu Ala

1 5ctc aac atg gcc ggc gtc acc gtg cgg cgc ggc gag aaa ttg ctt ctc 163Leu Asn Met Ala Gly Val Thr Val Arg Arg Gly Glu Lys Leu Leu Leu

10 15 20gac gat atc tcc ctc tca att ccg caa ggg tcg cac tgg gcc gta ctt 211Asp Asp Ile Ser Leu Ser Ile Pro Gln Gly Ser His Trp Ala Val Leu

25 30 35ggt cca aat ggc gcc ggt aaa acc acc atg ctg aag atc gca gcc acc 259Gly Pro Asn Gly Ala Gly Lys Thr Thr Met Leu Lys Ile Ala Ala Thr

40 45 50ttg ctg tac cca tcg gaa ggc acc gtg gac atc ctg ggg cat cgc ttt 307Leu Leu Tyr Pro Ser Glu Gly Thr Val Asp Ile Leu Gly His Arg Phe

55 60 65ggt cgg gtg gat act cgt gag ctg cgg aaa aca atc ggc ctg gtg gac 355Gly Arg Val Asp Thr Arg Glu Leu Arg Lys Thr Ile Gly Leu Val Asp 70 75 80 85ccg aag caa aga ttt acc aac ctg ccg gcc cac gaa att gtg ctg tcg 403Pro Lys Gln Arg Phe Thr Asn Leu Pro Ala His Glu Ile Val Leu Ser

90 95 100ggg tta acc gcc tcc aac ggg ttg ttg cca cgg tgg tcg gct tcg gct 451Gly Leu Thr Ala Ser Asn Gly Leu Leu Pro Arg Trp Ser Ala Ser Ala

105 110 115tcg gag ttg gag cgg tgc gct ttg atg ttg gag ttg gtg ggc atg aca 499Ser Glu Leu Glu Arg Cys Ala Leu Met Leu Glu Leu Val Gly Met Thr

120 125 130gcg cgt gcc gat cgt tac tgg gcc gat atg agc cag ggc gaa aaa gcc 547Ala Arg Ala Asp Arg Tyr Trp Ala Asp Met Ser Gln Gly Glu Lys Ala

135 140 145cgc acc ctg att gct cgt gcg ctg att atc tca ccg acc cta ctg ctg 595Arg Thr Leu Ile Ala Arg Ala Leu Ile Ile Ser Pro Thr Leu Leu Leu150 155 160 165ctt gat gaa ccc acc acc ggc ctt gac ctg ccc gga cgt gaa act ttg 643Leu Asp Glu Pro Thr Thr Gly Leu Asp Leu Pro Gly Arg Glu Thr Leu

170 175 180ctc agt gtg att gat ggt ttg cga gcc gct ctt cct ggt ctg acg aca 691Leu Ser Val Ile Asp Gly Leu Arg Ala Ala Leu Pro Gly Leu Thr Thr

185 190 195gtg atg atc acc cac cac gtc gaa gag atc gcc gcc tcc acg aca gat 739Val Met Ile Thr His His Val Glu Glu Ile Ala Ala Ser Thr Thr Asp

200 205 210atc ctc atg atc aag gac gcc cgc ata ctg gct tcg ggg act gtt tca 787Ile Leu Met Ile Lys Asp Ala Arg Ile Leu Ala Ser Gly Thr Val Ser

215 220 225gaa gtg atg act cct gaa aat ttg ggc gcg ctg tat gac atg tcg gtg 835Glu Val Met Thr Pro Glu Asn Leu Gly Ala Leu Tyr Asp Met Ser Val230 235 240 245tcg ttg gaa act gtg cgc agc cgg tgg ttc gcg ttc gat gct ctg cat 883Ser Leu Glu Thr Val Arg Ser Arg Trp Phe Ala Phe Asp Ala Leu His

250255260 taaaaggggc tagttttaca caa 906<210>478<211>261<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>478Met Arg Glu Leu Ala Leu Asn Met Ala Gly Val Thr Val Arg Arg Gly 151015 Glu Lys Leu Leu Leu Asp Asp Ile Ser Leu Ser Ile Pro Gln Gly Ser

20 25 30His Trp Ala Val Leu Gly Pro Asn Gly Ala Gly Lys Thr Thr Met Leu

3540 45Lys Ile Ala Ala Thr Leu Leu Tyr Pro Ser Glu Gly Thr Val Asp Ile

50 55 60Leu Gly His Arg Phe Gly Arg Val Asp Thr Arg Glu Leu Arg Lys Thr 65 70 75 80Ile Gly Leu Val Asp Pro Lys Gln Arg Phe Thr Asn Leu Pro Ala His

85 90 95Glu Ile Val Leu Ser Gly Leu Thr Ala Ser Asn Gly Leu Leu Pro Arg

100 105 110Trp Ser Ala Ser Ala Ser Glu Leu Glu Arg Cys Ala Leu Met Leu Glu

115 120 125Leu Val Gly Met Thr Ala Arg Ala Asp Arg Tyr Trp Ala Asp Met Ser

130 135 140Gln Gly Glu Lys Ala Arg Thr Leu Ile Ala Arg Ala Leu Ile Ile Ser145 150 155 160Pro Thr Leu Leu Leu Leu Asp Glu Pro Thr Thr Gly Leu Asp Leu Pro

165 170 175Gly Arg Glu Thr Leu Leu Ser Val Ile Asp Gly Leu Arg Ala Ala Leu

180 185 190Pro Gly Leu Thr Thr Val Met Ile Thr His His Val Glu Glu Ile Ala

195 200 205Ala Ser Thr Thr Asp Ile Leu Met Ile Lys Asp Ala Arg Ile Leu Ala

210 215 220Ser Gly Thr Val Ser Glu Val Met Thr Pro Glu Asn Leu Gly Ala Leu225 230 235 240Tyr Asp Met Ser Val Ser Leu Glu Thr Val Arg Ser Arg Trp Phe Ala

245 250 255Phe Asp Ala Leu His

260<210>479<211>876<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (853)<223>RXA02792<400>479agaacaaagt gctgcccata ctcatgaact ttgccgaacc cccaaccccg ctggccgtcg 60atggcctaga aaaaatcatc gactttgtgg aaacccaccc atg atc gag gcc aca 115

Met Ile Glu Ala Thr

1 5cac cta cgc cac agt ttt ggc gac aac atc gtc atc gat gac gtc acc 163His Leu Arg His Ser Phe Gly Asp Asn Ile Val Ile Asp Asp Val Thr

10 15 20ctc cat cta cct gca cac ggc acc gtc agc ttg gtc ggc ccc aac ggc 211Leu His Leu Pro Ala His Gly Thr Val Ser Leu Val Gly Pro Asn Gly

25 30 35agt ggc aaa acc acc ctg ctg cgt gca cta tac gga gca ctg caa cca 259Ser Gly Lys Thr Thr Leu Leu Arg Ala Leu Tyr Gly Ala Leu Gln Pro

40 45 50aat gaa ggg cac atc cac gta gat ggc gtt cca cta ata agc ttg cac 307Asn Glu Gly His Ile His Val Asp Gly Val Pro Leu Ile Ser Leu His

55 60 65cgc aaa gac atc gca aaa acc atg gcc gta gtc atc caa gaa cat gac 355Arg Lys Asp Ile Ala Lys Thr Met Ala Val Val Ile Gln Glu His Asp 70 75 80 85tcc gac ctc ccc atg acc gtc gct gac ctg gtc tta cta ggc aga ctc 403Ser Asp Leu Pro Met Thr Val Ala Asp Leu Val Leu Leu Gly Arg Leu

90 95 100ccc cac caa aag atg ttt gcc ggc aac tct caa gct gat cag tta ctc 451Pro His Gln Lys Met Phe Ala Gly Asn Ser Gln Ala Asp Gln Leu Leu

105 110 115gtt aag gaa gca ctc acc cga gtc ggcgcc att cac ctg gcc gac cga 499Val Lys Glu Ala Leu Thr Arg Val Gly Ala Ile His Leu Ala Asp Arg

120 125 130caa ttc ggc gca ctt tca ggc ggt gaa cgc caa cgc gtc ctc atc gca 547Gln Phe Gly Ala Leu Ser Gly Gly Glu Arg Gln Arg Val Leu Ile Ala

135 140 145cga gca ctc gta caa aac gcc aca cac att ctg ctc gac gaa ccc acc 595Arg Ala Leu Val Gln Asn Ala Thr His Ile Leu Leu Asp Glu Pro Thr150 155 160 165aac cac ctc gac atc cgc tac cag cac gaa gtc ctt cac ctc gtc cgc 643Asn His Leu Asp Ile Arg Tyr Gln His Glu Val Leu His Leu Val Arg

170 175 180gaa ctc agc tca agt tcc atc atc gtc ctc cac gac ctc aac ctc gca 691Glu Leu Ser Ser Ser Ser Ile Ile Val Leu His Asp Leu Asn Leu Ala

185 190 195ggt gcc tac agc gac cac atc atc ctc ctt gac caa gga cgt gtg gtt 739Gly Ala Tyr Ser Asp His Ile Ile Leu Leu Asp Gln Gly Arg Val Val

200 205 210act caa gga acg ccc tca gag gta ttg acc cca gag cat ttg gaa cct 787Thr Gln Gly Thr Pro Ser Glu Val Leu Thr Pro Glu His Leu Glu Pro

215 220 225gtg tat ggc gtt cgt gtt gag cgc ttt gac cta ggc gat gaa gtc cac 835Val Tyr Gly Val Arg Val Glu Arg Phe Asp Leu Gly Asp Glu Val His230 235 240 245ctt cgg ttc aag cgt cac taggagtttt gttgaggagg tgg 876Leu Arg Phe Lys Arg His

250<210>480<211>251<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>480Met Ile Glu Ala Thr His Leu Arg His Ser Phe Gly Asp Asn Ile Val 151015 Ile Asp Asp Val Thr Leu His Leu Pro AlaHis Gly Thr Val Ser Leu

20 25 30Val Gly Pro Asn Gly Ser Gly Lys Thr Thr Leu Leu Arg Ala Leu Tyr

35 40 45Gly Ala Leu Gln Pro Asn Glu Gly His Ile His Val Asp Gly Val Pro

50 55 60Leu Ile Ser Leu His Arg Lys Asp Ile Ala Lys Thr Met Ala Val Val 65 70 75 80Ile Gln Glu His Asp Ser Asp Leu Pro Met Thr Val Ala Asp Leu Val

85 90 95Leu Leu Gly Arg Leu Pro His Gln Lys Met Phe Ala Gly Asn Ser Gln

100 105 110Ala Asp Gln Leu Leu Val Lys Glu Ala Leu Thr Arg Val Gly Ala Ile

115 120 125His Leu Ala Asp Arg Gln Phe Gly Ala Leu Ser Gly Gly Glu Arg Gln

130 135 140Arg Val Leu Ile Ala Arg Ala Leu Val Gln Asn Ala Thr His Ile Leu145 150 155 160Leu Asp Glu Pro Thr Asn His Leu Asp Ile Arg Tyr Gln His Glu Val

165 170 175Leu His Leu Val Arg Glu Leu Ser Ser Ser Ser Ile Ile Val Leu His

180 185 190Asp Leu Asn Leu Ala Gly Ala Tyr Ser Asp His Ile Ile Leu Leu Asp

195 200 205Gln Gly Arg Val Val Thr Gln Gly Thr Pro Ser Glu Val Leu Thr Pro

210 215 220Glu His Leu Glu Pro Val Tyr Gly Val Arg Val Glu Arg Phe Asp Leu225 230 235 240Gly Asp Glu Val His Leu Arg Phe Lys Arg His

245250<210>481<211>1161<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1138)<223>RXN02929<400>481caggtgggga cctcgcgtat cccagctggt ggaagaaatc gcagcgcagt tgaatcagct 60tgcttcttct gaagctgtgc cggccgctgc ttaagttttc gtg ctg aag aga att 115

Val Leu Lys Arg Ile

1 5ttc ctc aac ccc tgg gtg gct acc gcg ttg tcg gta gtc att ttg ggg 163Phe Leu Asn Pro Trp Val Ala Thr Ala Leu Ser Val Val Ile Leu Gly

10 15 20ttt gtg gtg ctg ttt tca ggt ttt agc ggt gtt att gat tta agc ccc 211Phe Val Val Leu Phe Ser Gly Phe Ser Gly Val Ile Asp Leu Ser Pro

25 30 35aca gca gtg att aga cat ttg agt ggg cag gac acg ctc acc cct cga 259Thr Ala Val Ile Arg His Leu Ser Gly Gln Asp Thr Leu Thr Pro Arg

40 45 50gat cag gcc atc ttc ttt gat atc cgg ctg cct cga att atc gct ggt 307Asp Gln Ala Ile Phe Phe Asp Ile Arg Leu Pro Arg Ile Ile Ala Gly

55 60 65gtc att gtc gga gca acg ctg gct att tct ggt gct tct tac caa gcg 355Val Ile Val Gly Ala Thr Leu Ala Ile Ser Gly Ala Ser Tyr Gln Ala 70 75 80 85gta ttt aga aac ccg ctg gct gat cct tat ttg ttg ggt gtg tcc gca 403Val Phe Arg Asn Pro Leu Ala Asp Pro Tyr Leu Leu Gly Val Ser Ala

90 95 100ggt tct ggc ctt ggt gtc acg gca gtg att gtt ggc ggt acc gtg ctg 451Gly Ser Gly Leu Gly Val Thr Ala Val Ile Val Gly Gly Thr Val Leu

105110 115gga ttt tct gca ccg agc atc ggc gtg att ggt gca gca ttt gta ggt 499Gly Phe Ser Ala Pro Ser Ile Gly Val Ile Gly Ala Ala Phe Val Gly

120 125 130ggt gtt gcc gca gta ctt gcc acg ctg atg gtg agt cgg gga gta gga 547Gly Val Ala Ala Val Leu Ala Thr Leu Met Val Ser Arg Gly Val Gly

135 140 145cag gga tca tca acc acc gtg gtt att ttg gcg ggc gtg gcg gtt gct 595Gln Gly Ser Ser Thr Thr Val Val Ile Leu Ala Gly Val Ala Val Ala150 155 160 165gct ttt gcc agt tcc atc cag acc tat att cag caa cga cac atc gat 643Ala Phe Ala Ser Ser Ile Gln Thr Tyr Ile Gln Gln Arg His Ile Asp

170 175 180acg gtg gcg cgc gta tat gtg tgg atg ttg ggc aac ctc aat gtc acc 691Thr Val Ala Arg Val Tyr Val Trp Met Leu Gly Asn Leu Asn Val Thr

185 190 195aac tgg atg tcg atc ttc atc gtg gct gtg gtg gcg gga cta tgc gcg 739Asn Trp Met Ser Ile Phe Ile Val Ala Val Val Ala Gly Leu Cys Ala

200 205 210gcc gtg atc atg tcc tgc gcc agg ttg tta gac gtg atg gct gtt ggt 787Ala Val Ile Met Ser Cys Ala Arg Leu Leu Asp Val Met Ala Val Gly

215 220 225gat gtg gaa gcc cgc aca ttg ggc gtc gat cca ggc ctc gta cgc att 835Asp Val Glu Ala Arg Thr Leu Gly Val Asp Pro Gly Leu Val Arg Ile230 235 240 245ggc att gtc atc gtg gca acc ctt ggt aca gct gca gtg gta tcc att 883Gly Ile Val Ile Val Ala Thr Leu Gly Thr Ala Ala Val Val Ser Ile

250 255 260tcc ggt ctc atc ggg ttt gtg ggc atc att gtt ccg cac gcc ctg cgc 931Ser Gly LeuIle Gly Phe Val Gly Ile Ile Val Pro His Ala Leu Arg

265 270 275cta att gtt ggc ccg ggg cat cgg att tta ctg cca ctg tct ttc gta 979Leu Ile Val Gly Pro Gly His Arg Ile Leu Leu Pro Leu Ser Phe Val

280 285 290tgg ggt gcc att ttc ctc gtg ttg gca gat acc gca ggg cga aca ttg 1027Trp Gly Ala Ile Phe Leu Val Leu Ala Asp Thr Ala Gly Arg Thr Leu

295 300 305atg gct cct cag gaa ctt ccc gtg ggt gtg gtg aca gct gca ctc ggc 1075Met Ala Pro Gln Glu Leu Pro Val Gly Val Val Thr Ala Ala Leu Gly310 315 320 325gca ccg ttc ttc tta ttt att ttg cgc aga acc agc aga caa cga gtt 1123Ala Pro Phe Phe Leu Phe Ile Leu Arg Arg Thr Ser Arg Gln Arg Val

330 335 340cca aaa agg agt gct taagtggcga tcattgaatg cga 1161Pro Lys Arg Ser Ala

345<210>482<211>346<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>482Val Leu Lys Arg Ile Phe Leu Asn Pro Trp Val Ala Thr Ala Leu Ser 151015 Val Val Ile Leu Gly Phe Val Val Leu Phe Ser Gly Phe Ser Gly Val

20 25 30Ile Asp Leu Ser Pro Thr Ala Val Ile Arg His Leu Ser Gly Gln Asp

35 40 45Thr Leu Thr Pro Arg Asp Gln Ala Ile Phe Phe Asp Ile Arg Leu Pro

50 55 60Arg Ile Ile Ala Gly Val Ile Val Gly Ala Thr Leu Ala Ile Ser Gly 65 70 75 80Ala Ser Tyr Gln Ala Val Phe Arg Asn Pro Leu Ala Asp Pro Tyr Leu

8590 95Leu Gly Val Ser Ala Gly Ser Gly Leu Gly Val Thr Ala Val Ile Val

100 105 110Gly Gly Thr Val Leu Gly Phe Ser Ala Pro Ser Ile Gly Val Ile Gly

115 120 125Ala Ala Phe Val Gly Gly Val Ala Ala Val Leu Ala Thr Leu Met Val

130 135 140Ser Arg Gly Val Gly Gln Gly Ser Ser Thr Thr Val Val Ile Leu Ala145 150 155 160Gly Val Ala Val Ala Ala Phe Ala Ser Ser Ile Gln Thr Tyr Ile Gln

165 170 175Gln Arg His Ile Asp Thr Val Ala Arg Val Tyr Val Trp Met Leu Gly

180 185 190Asn Leu Asn Val Thr Asn Trp Met Ser Ile Phe Ile Val Ala Val Val

195 200 205Ala Gly Leu Cys Ala Ala Val Ile Met Ser Cys Ala Arg Leu Leu Asp

210 215 220Val Met Ala Val Gly Asp Val Glu Ala Arg Thr Leu Gly Val Asp Pro225 230 235 240Gly Leu Val Arg Ile Gly Ile Val Ile Val Ala Thr Leu Gly Thr Ala

245 250 255Ala Val Val Ser Ile Ser Gly Leu Ile Gly Phe Val Gly Ile Ile Val

260 265 270Pro His Ala Leu Arg Leu Ile Val Gly Pro Gly His Arg Ile Leu Leu

275 280 285Pro Leu Ser Phe Val Trp Gly Ala Ile Phe Leu Val Leu Ala Asp Thr

290 295 300Ala Gly Arg Thr Leu Met Ala Pro Gln Glu Leu Pro Val Gly Val Val305 310 315 320Thr Ala Ala LeuGly Ala Pro Phe Phe Leu Phe Ile Leu Arg Arg Thr

325 330 335Ser Arg Gln Arg Val Pro Lys Arg Ser Ala

340345<210>483<211>1095<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1072)<223>FRXA01235<400>483ttctgaagct gtgccggccg ctgcttaagt tttcgtgctg aagagaattt tcctcaaccc 60ctgggtggct accgcgttgt cggtagtcat tttggggttt gtg gtg ctg ttt tca 115

Val Val Leu Phe Ser

1 5ggt ttt agc ggt gtt att gat tta agc ccc aca gca gtg att aga cat 163Gly Phe Ser Gly Val Ile Asp Leu Ser Pro Thr Ala Val Ile Arg His

10 15 20ttg agt ggg cag gac acg ctc acc cct cga gat cag gcc atc ttc ttt 211Leu Ser Gly Gln Asp Thr Leu Thr Pro Arg Asp Gln Ala Ile Phe Phe

25 30 35gat atc cgg ctg cct cga att atc gct ggt gtc att gtc gga gca acg 259Asp Ile Arg Leu Pro Arg Ile Ile Ala Gly Val Ile Val Gly Ala Thr

40 45 50ctg gct att tct ggt gct gct tac caa gcg gta ttt aga aac ccg ctg 307Leu Ala Ile Ser Gly Ala Ala Tyr Gln Ala Val Phe Arg Asn Pro Leu

55 60 65gct gat cct tat ttg ttg ggt gtg tcc gca ggt tct ggc ctt ggt gtc 355Ala Asp Pro Tyr Leu Leu Gly Val Ser Ala Gly Ser Gly Leu Gly Val 70 75 80 85acg gca gtg att gtt ggc ggt acc gtg ctg gga ttt tct gca ccg agc 403Thr Ala Val Ile Val Gly Gly Thr Val Leu Gly Phe Ser Ala Pro Ser

90 95100atc ggc gtg att ggt gca gca ttt gta ggt ggt gtt gcc gca gta ctt 451Ile Gly Val Ile Gly Ala Ala Phe Val Gly Gly Val Ala Ala Val Leu

105 110 115gcc acg ctg atg gtg agt cgg gga gta gga cag gga tca tca acc acc 499Ala Thr Leu Met Val Ser Arg Gly Val Gly Gln Gly Ser Ser Thr Thr

120 125 130gtg gtt att ttg gcg ggc gtg gcg gtt gct gct ttt gcc agt tcc atc 547Val Val Ile Leu Ala Gly Val Ala Val Ala Ala Phe Ala Ser Ser Ile

135 140 145cag acc tat att cag caa cga cac atc gat acg gtg gcg cgc gta tat 595Gln Thr Tyr Ile Gln Gln Arg His Ile Asp Thr Val Ala Arg Val Tyr150 155 160 165gtg tgg atg ttg ggc aac ctc aat gtc acc aac tgg atg tcg atc ttc 643Val Trp Met Leu Gly Asn Leu Asn Val Thr Asn Trp Met Ser Ile Phe

170 175 180atc gtg gct gtg gtg gcg gga cta tgc gcg gcc gtg atc atg tcc tgc 691Ile Val Ala Val Val Ala Gly Leu Cys Ala Ala Val Ile Met Ser Cys

185 190 195gcc agg ttg tta gac gtg atg gct gtt ggt gat gtg gaa gcc cgc aca 739Ala Arg Leu Leu Asp Val Met Ala Val Gly Asp Val Glu Ala Arg Thr

200 205 210ttg ggc gtc gat cca ggc ctc gta cgc att ggc att gtc atc gtg gca 787Leu Gly Val Asp Pro Gly Leu Val Arg Ile Gly Ile Val Ile Val Ala

215 220 225acc ctt ggt aca gct gca gtg gta tcc att tcc ggt ctc atc ggg ttt 835Thr Leu Gly Thr Ala Ala Val Val Ser Ile Ser Gly Leu Ile Gly Phe230 235 240 245gtg ggc atc att gtt ccg cac gcc ctg cgc cta att gtt ggc ccg ggg 883Val Gly Ile Ile Val ProHis Ala Leu Arg Leu Ile Val Gly Pro Gly

250 255 260cat cgg att tta ctg cca ctg tct ttc gta tgg ggt gcc att ttc ctc 931His Arg Ile Leu Leu Pro Leu Ser Phe Val Trp Gly Ala Ile Phe Leu

265 270 275gtg ttg gca gat acc gca ggg cga aca ttg atg gct cct cag gaa ctt 979Val Leu Ala Asp Thr Ala Gly Arg Thr Leu Met Ala Pro Gln Glu Leu

280 285 290ccc gtg ggt gtg gtg aca gct gca ctc ggc gca ccg ttc ttc tta ttt 1027Pro Val Gly Val Val Thr Ala Ala Leu Gly Ala Pro Phe Phe Leu Phe

295300305 att ttg cgc aga acc agc aga caa cga gtt cca aaa agg agt gct 1072Ile Leu Arg Arg Thr Ser Arg Gln Arg Val Pro Lys Arg Ser Ala 310315320 taagtggcga tcattgaatg cga 1095<210>484<211>324<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>484Val Val Leu Phe Ser Gly Phe Ser Gly Val Ile Asp Leu Ser Pro Thr 151015 Ala Val Ile Arg His Leu Ser Gly Gln Asp Thr Leu Thr Pro Arg Asp

20 25 30Gln Ala Ile Phe Phe Asp Ile Arg Leu Pro Arg Ile Ile Ala Gly Val

35 40 45Ile Val Gly Ala Thr Leu Ala Ile Ser Gly Ala Ala Tyr Gln Ala Val

50 55 60Phe Arg Asn Pro Leu Ala Asp Pro Tyr Leu Leu Gly Val Ser Ala Gly 65 70 75 80Ser Gly Leu Gly Val Thr Ala Val Ile Val Gly Gly Thr Val Leu Gly

85 90 95Phe Ser Ala Pro Ser Ile Gly Val Ile Gly Ala Ala Phe Val Gly Gly

100 105 110Val Ala Ala Val Leu Ala Thr Leu Met Val Ser Arg Gly Val Gly Gln

115 120 125Gly Ser Ser Thr Thr Val Val Ile Leu Ala Gly Val Ala Val Ala Ala

130 135 140Phe Ala Ser Ser Ile Gln Thr Tyr Ile Gln Gln Arg His Ile Asp Thr145 150 155 160Val Ala Arg Val Tyr Val Trp Met Leu Gly Asn Leu Asn Val Thr Asn

165 170 175Trp Met Ser Ile Phe Ile Val Ala Val Val Ala Gly Leu Cys Ala Ala

180 185 190Val Ile Met Ser Cys Ala Arg Leu Leu Asp Val Met Ala Val Gly Asp

195 200 205Val Glu Ala Arg Thr Leu Gly Val Asp Pro Gly Leu Val Arg Ile Gly

210 215 220Ile Val Ile Val Ala Thr Leu Gly Thr Ala Ala Val Val Ser Ile Ser225 230 235 240Gly Leu Ile Gly Phe Val Gly Ile Ile Val Pro His Ala Leu Arg Leu

245 250 255Ile Val Gly Pro Gly His Arg Ile Leu Leu Pro Leu Ser Phe Val Trp

260 265 270Gly Ala Ile Phe Leu Val Leu Ala Asp Thr Ala Gly Arg Thr Leu Met

275 280 285Ala Pro Gln Glu Leu Pro Val Gly Val Val Thr Ala Ala Leu Gly Ala

290295300 Pro Phe Phe Leu Phe Ile Leu Arg Arg Thr Ser Arg Gln Arg Val Pro 305310315320 Lys Arg Ser Ala<210>485<211>1197<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1174)<223>RXN02794<400>485gcgcccactc atcggcgagc ttcaggagat gaggttgatg ctccattgat aatttctttc 60gctaatagtc aaatgatcat ttgagtgtta gtgttttctc atg ctt ctt tcc gcc 115

Met Leu Leu Ser Ala

1 5cgc aca cac acg agt ttc caa gaa ctt gga ctc aat gct agt cgg cgc 163Arg Thr His Thr Ser Phe Gln Glu Leu Gly Leu Asn Ala Ser Arg Arg

10 15 20aaa gca atc aac tgg aca ctg gca ctc act gtg gtg cta att gcc tcc 211Lys Ala Ile Asn Trp Thr Leu Ala Leu Thr Val Val Leu Ile Ala Ser

25 30 35atg ttt gtt ggc gtg ctc atc ggt gca tcc ggg acc tca gtg ttt tcc 259Met Phe Val Gly Val Leu Ile Gly Ala Ser Gly Thr Ser Val Phe Ser

40 45 50acg tgg acc gta att agc cac cat ctt ttt ggc act gag cta ggt ggc 307Thr Trp Thr Val Ile Ser His His Leu Phe Gly Thr Glu Leu Gly Gly

55 60 65tcc gac act gcc gac gcc atc att tgg tac atc cgc acc cca cgc gtc 355Ser Asp Thr Ala Asp Ala Ile Ile Trp Tyr Ile Arg Thr Pro Arg Val 70 75 80 85ttg ctc gct gcc att gtg ggc gca ggc ctt gcc ctg gca ggt gcc atc 403Leu Leu Ala Ala Ile Val Gly Ala Gly Leu Ala Leu Ala Gly Ala Ile

90 95 100atg caa gta ctg gtc cga aac atg ctg gca gac ccc tat atc ctc ggg 451Met Gln Val Leu Val Arg Asn Met Leu Ala Asp Pro Tyr Ile Leu Gly

105 110 115gtg aac tca ggt gcc agt tgc ggt gcg gcc gct gcc tta ctg ttc gga 499Val Asn Ser Gly Ala Ser Cys Gly Ala Ala Ala Ala Leu Leu Phe Gly

120 125 130gtg ggc gct gga ttt ggc gat tac gcc ctc caa ggc agc gcg ttt ctc547Val Gly Ala Gly Phe Gly Asp Tyr Ala Leu Gln Gly Ser Ala Phe Leu

135 140 145ggc gca atg gca gct tcc gga ttg atc ttc ttc gtg gcg cgc gca gcg 595Gly Ala Met Ala Ala Ser Gly Leu Ile Phe Phe Val Ala Arg Ala Ala150 155 160 165ggg cgc atc tcc tcg acc cgc ttg ttg atg tcc ggc gta gcg atc gga 643Gly Arg Ile Ser Ser Thr Arg Leu Leu Met Ser Gly Val Ala Ile Gly

170 175 180tac atg ctc tct gcg gca aca agc ttt ctc atc ttc tcc tcc gac tcc 691Tyr Met Leu Ser Ala Ala Thr Ser Phe Leu Ile Phe Ser Ser Asp Ser

185 190 195gcc gaa ggc agc cgc tcc gtg ttg ttc tgg ctg ctt gga tcc tta gga 739Ala Glu Gly Ser Arg Ser Val Leu Phe Trp Leu Leu Gly Ser Leu Gly

200 205 210ctt gcc gca tgg aat ggg ccg atg gcg atc atc ttc ctc atc gtg ggc 787Leu Ala Ala Trp Asn Gly Pro Met Ala Ile Ile Phe Leu Ile Val Gly

215 220 225att gcc ctg gcg ttg ctc atg gtg ttg ggt ccg caa ttg gat gcc tta 835Ile Ala Leu Ala Leu Leu Met Val Leu Gly Pro Gln Leu Asp Ala Leu230 235 240 245aac tcc ggc gat gaa acc gca ctt acc ttg gga gta tcc cct gat cgc 883Asn Ser Gly Asp Glu Thr Ala Leu Thr Leu Gly Val Ser Pro Asp Arg

250 255 260ctc cgc att ctc ctc ctg gtg atc acc tgc ctg ctg gtg gga tcc atg 931Leu Arg Ile Leu Leu Leu Val Ile Thr Cys Leu Leu Val Gly Ser Met

265 270 275gtt gcc atg gcc ggc agc atc gga ttc atc ggc ctt gtc atc ccc cac 979Val Ala Met Ala Gly Ser Ile Gly Phe Ile Gly Leu Val Ile Pro His

280 285 290ctg gcc agg cgt ttt gtt agt gga aaa cac cga ctc atg ctg cct gta 1027Leu Ala Arg Arg Phe Val Ser Gly Lys His Arg Leu Met Leu Pro Val

295 300 305tcc gcg ttg atg ggc gca att ttg ctc atc tgg gct gat atc gcc gcc 1075Ser Ala Leu Met Gly Ala Ile Leu Leu Ile Trp Ala Asp Ile Ala Ala310 315 320 325cgc acc ctg ctt gcg ccc caa gag att ccc atc ggc atc atc acc gca 1123Arg Thr Leu Leu Ala Pro Gln Glu Ile Pro Ile Gly Ile Ile Thr Ala

330 335 340ctc atc gga gca ccc ttc ctc ctg att ctg gtt cgc cgg atg cac acc 1171Leu Ile Gly Ala Pro Phe Leu Leu Ile Leu Val Arg Arg Met His Thr

345350355 tac tgatttttaa ggaattatgc gta 1197Tyr<210>486<211>358<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>486Met Leu Leu Ser Ala Arg Thr His Thr Ser Phe Gln Glu Leu Gly Leu 151015 Asn Ala Ser Arg Arg Lys Ala Ile Asn Trp Thr Leu Ala Leu Thr Val

20 25 30Val Leu Ile Ala Ser Met Phe Val Gly Val Leu Ile Gly Ala Ser Gly

35 40 45Thr Ser Val Phe Ser Thr Trp Thr Val Ile Ser His His Leu Phe Gly

50 55 60Thr Glu Leu Gly Gly Ser Asp Thr Ala Asp Ala Ile Ile Trp Tyr Ile 65 70 75 80Arg Thr Pro Arg Val Leu Leu Ala Ala Ile Val Gly Ala Gly Leu Ala

85 90 95Leu Ala Gly Ala Ile Met Gln Val Leu Val Arg Asn Met Leu Ala Asp

100 105 110Pro Tyr Ile Leu Gly Val Asn Ser Gly Ala Ser Cys Gly Ala Ala Ala

115 120 125Ala Leu Leu Phe Gly Val Gly Ala Gly Phe Gly Asp Tyr Ala Leu Gln

130 135 140Gly Ser Ala Phe Leu Gly Ala Met Ala Ala Ser Gly Leu Ile Phe Phe145 150 155 160Val Ala Arg Ala Ala Gly Arg Ile Ser Ser Thr Arg Leu Leu Met Ser

165 170 175Gly Val Ala Ile Gly Tyr Met Leu Ser Ala Ala Thr Ser Phe Leu Ile

180 185 190Phe Ser Ser Asp Ser Ala Glu Gly Ser Arg Ser Val Leu Phe Trp Leu

195 200 205Leu Gly Ser Leu Gly Leu Ala Ala Trp Asn Gly Pro Met Ala Ile Ile

210 215 220Phe Leu Ile Val Gly Ile Ala Leu Ala Leu Leu Met Val Leu Gly Pro225 230 235 240Gln Leu Asp Ala Leu Asn Ser Gly Asp Glu Thr Ala Leu Thr Leu Gly

245 250 255Val Ser Pro Asp Arg Leu Arg Ile Leu Leu Leu Val Ile Thr Cys Leu

260 265 270Leu Val Gly Ser Met Val Ala Met Ala Gly Ser Ile Gly Phe Ile Gly

275 280 285Leu Val Ile Pro His Leu Ala Arg Arg Phe Val Ser Gly Lys His Arg

290 295 300Leu Met Leu Pro Val Ser Ala Leu Met Gly Ala Ile Leu Leu Ile Trp305 310 315 320Ala Asp Ile Ala Ala Arg Thr Leu Leu Ala Pro Gln Glu Ile Pro Ile

325 330 335Gly Ile Ile Thr Ala Leu Ile Gly Ala Pro Phe Leu Leu Ile Leu Val

340 345 350Arg Arg Met His Thr Tyr

355<210>487<211>364<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (364)<223>FRXA01419<400>487gcgcccactc atcggcgagc ttcaggagat gaggttgatg ctccattgat aatttctttc 60gctaatagtc aaatgatcat ttgagtgtta gtgttttctc atg ctt ctt tcc gcc 115

Met Leu Leu Ser Ala

1 5cgc aca cac acg agt ttc caa gaa ctt gga ctc aat gct agt cgg cgc 163Arg Thr His Thr Ser Phe Gln Glu Leu Gly Leu Asn Ala Ser Arg Arg

10 15 20aaa gca atc aac tgg aca ctg gca ctc act gtg gtg cta att gcc tcc 211Lys Ala Ile Asn Trp Thr Leu Ala Leu Thr Val Val Leu Ile Ala Ser

25 30 35atg ttt gtt ggc gtg ctc atc ggt gca tcc ggg acc tca gtg ttt tcc 259Met Phe Val Gly Val Leu Ile Gly Ala Ser Gly Thr Ser Val Phe Ser

40 45 50acg tgg acc gta att agc cac cat ctt ttt ggc act gag cta ggt ggc 307Thr Trp Thr Val Ile Ser His His Leu Phe Gly Thr Glu Leu Gly Gly

556065 tcc gac act gcc gac gcc atc att tgg tac atc cgc acc cca cgc gtc 355Ser Asp Thr Ala Asp Ala Ile Ile Trp Tyr Ile Arg Thr Pro Arg Val 70758085 ttg ctc gct 364Leu Ala<210>488<211>88<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>488Met Leu Leu Ser Ala Arg Thr His Thr Ser Phe Gln Glu Leu Gly Leu 151015 Asn Ala Ser Arg Arg Lys Ala Ile Asn Trp Thr Leu Ala Leu Thr Val

20 2530Val Leu Ile Ala Ser Met Phe Val Gly Val Leu Ile Gly Ala Ser Gly

35 40 45Thr Ser Val Phe Ser Thr Trp Thr Val Ile Ser His His Leu Phe Gly

50 55 60Thr Glu Leu Gly Gly Ser Asp Thr Ala Asp Ala Ile Ile Trp Tyr Ile 65 70 75 80Arg Thr Pro Arg Val Leu Leu Ala

85<210>489<211>744<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (721)<223>FRXA02794<400>489tgaactcagg tgccagttgc ggtgcggccg ctgccttact gttcggagtg ggcgctggat 60ttggcgatta cgccctccaa gcagcgcgtt tctcggcgca atg gca gct tcc gga 115

Met Ala Ala Ser Gly

1 5ttg atc ttc ttc gtg gcg cgc gca gcg ggg cgc atc tcc tcg acc cgc 163Leu Ile Phe Phe Val Ala Arg Ala Ala Gly Arg Ile Ser Ser Thr Arg

10 15 20ttg ttg atg tcc ggc gta gcg atc gga tac atg ctc tct gcg gca aca 211Leu Leu Met Ser Gly Val Ala Ile Gly Tyr Met Leu Ser Ala Ala Thr

25 30 35agc ttt ctc atc ttc tcc tcc gac tcc gcc gaa ggc agc cgc tcc gtg 259Ser Phe Leu Ile Phe Ser Ser Asp Ser Ala Glu Gly Ser Arg Ser Val

40 45 50ttg ttc tgg ctg ctt gga tcc tta gga ctt gcc gca tgg aat ggg ccg 307Leu Phe Trp Leu Leu Gly Ser Leu Gly Leu Ala Ala Trp Asn Gly Pro

55 60 65atg gcg atc atc ttc ctc atc gtg ggc att gcc ctg gcg ttg ctc atg 355Met Ala Ile Ile Phe Leu Ile Val Gly Ile Ala Leu Ala Leu Leu Met 70 75 80 85gtg ttg ggt ccg caa ttg gat gcc tta aac tcc ggc gat gaa acc gca 403Val Leu Gly Pro Gln Leu Asp Ala Leu Asn Ser Gly Asp Glu Thr Ala

90 95 100ctt acc ttg gga gta tcc cct gat cgc ctc cgc att ctc ctc ctg gtg 451Leu Thr Leu Gly Val Ser Pro Asp Arg Leu Arg Ile Leu Leu Leu Val

105 110 115atc acc tgc ctg ctg gtg gga tcc atg gtt gcc atg gcc ggc agc atc 499Ile Thr Cys Leu Leu Val Gly Ser Met Val Ala Met Ala Gly Ser Ile

120 125 130gga ttc atc ggc ctt gtc atc ccc cac ctg gcc agg cgt ttt gtt agt 547Gly Phe Ile Gly Leu Val Ile Pro His Leu Ala Arg Arg Phe Val Ser

135 140 145gga aaa cac cga ctc atg ctg cct gta tcc gcg ttg atg ggc gca att 595Gly Lys His Arg Leu Met Leu Pro Val Ser Ala Leu Met Gly Ala Ile150 155 160 165ttg ctc atc tgg gct gat atc gcc gcc cgc acc ctg ctt gcg ccc caa 643Leu Leu Ile Trp Ala Asp Ile Ala Ala Arg Thr Leu Leu Ala Pro Gln

170 175 180gag att ccc atc ggc atc atc acc gca ctc atc gga gca ccc ttc ctc 691Glu Ile Pro Ile Gly Ile Ile Thr Ala Leu Ile Gly Ala Pro Phe Leu

185 190 195ctg att ctg gtt cgc cgg atg cac acc tac tgatttttaa ggaattatgc 741Leu Ile Leu Val Arg Arg Met His Thr Tyr

200205 gta 744<210>490<211>207<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>490Met Ala Ala Ser Gly Leu Ile Phe Phe Val Ala Arg Ala Ala Gly Arg 151015 Ile Ser Ser Thr Arg Leu Leu Met Ser Gly Val Ala Ile Gly Tyr Met

20 25 30Leu Ser Ala Ala Thr Ser Phe Leu Ile Phe Ser Ser Asp Ser Ala Glu

35 40 45Gly Ser Arg Ser Val Leu Phe Trp Leu Leu Gly Ser Leu Gly Leu Ala

50 55 60Ala Trp Asn Gly Pro Met Ala Ile Ile Phe Leu Ile Val Gly Ile Ala 65 70 75 80Leu Ala Leu Leu Met Val Leu Gly Pro Gln Leu Asp Ala Leu Asn Ser

85 90 95Gly Asp Glu Thr Ala Leu Thr Leu Gly Val Ser Pro Asp Arg Leu Arg

100 105 110Ile Leu Leu Leu Val Ile Thr Cys Leu Leu Val Gly Ser Met Val Ala

115 120 125Met Ala Gly Ser Ile Gly Phe Ile Gly Leu Val Ile Pro His Leu Ala

130 135 140Arg Arg Phe Val Ser Gly Lys His Arg Leu Met Leu Pro Val Ser Ala145 150 155 160Leu Met Gly Ala Ile Leu Leu Ile Trp Ala Asp Ile Ala Ala Arg Thr

165 170 175Leu Leu Ala Pro Gln Glu Ile Pro Ile Gly Ile Ile Thr Ala Leu Ile

180 185 190Gly Ala Pro Phe Leu Leu Ile Leu Val Arg Arg Met His Thr Tyr

195200205<210>491<211>1140<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1117)<223>RXN03079<400>491gagcggggtt gctatcggcc gaaagtttag ggttttgttc aatctgttgg ttagtattgc 60ttgggtaaac aagtcataac aattttcatt aagggtcgtt ttg tcg cgc aca ggt 115

Leu Ser Arg Thr Gly

1 5gtt tcg aaa aaa cca aag ctc acc gct cct gtt gtc atc atc ggc acc 163Val Ser Lys Lys Pro Lys Leu Thr Ala Pro Val Val Ile Ile Gly Thr

10 15 20ctc gtc ttg ttg atc atc gcc ttc acc gct tcc ctc atg ctg ggt ccc 211Leu Val Leu Leu Ile Ile Ala Phe Thr Ala Ser Leu Met Leu Gly Pro

25 30 35gtg acg gtt cca ttg aat gag ctt gca acc aac ccc gtt gtc acc gat 259Val Thr Val Pro Leu Asn Glu Leu Ala Thr Asn Pro Val Val Thr Asp

40 45 50atc cgt gca cca cgc att atc atc gca gca ttg gtg ggt gcg gcg ctg 307Ile Arg Ala Pro Arg Ile Ile Ile Ala Ala Leu Val Gly Ala Ala Leu

55 60 65gct gtc tcc ggt gcg atc atg cag acg gtg ttt cac aac ccg ttg gcg 355Ala Val Ser Gly Ala Ile Met Gln Thr Val Phe His Asn Pro Leu Ala 70 75 80 85gat ccc ggc att gtg ggt gtg tcc tcc ggt gca gct gtt gca gct gtc 403Asp Pro Gly Ile Val Gly Val Ser Ser Gly Ala Ala Val Ala Ala Val

90 95 100ttg gcg att gtc acc ggt gcg agt ttc ttt ggc caa tgg acc gtt cct 451Leu Ala Ile Val Thr Gly Ala Ser Phe Phe Gly Gln Trp Thr Val Pro

105 110 115ttt gcg gcc ttc gtg ggc gca ttg gtc acg gtg gct gtg gta tat ttg 499Phe Ala Ala Phe Val Gly Ala Leu Val Thr Val Ala Val Val Tyr Leu

120 125 130atc gct agt tcc cgc gcg atg gat ggc cgt ggc gca gat ccg gcc acg 547Ile Ala Ser Ser Arg Ala Met Asp Gly Arg Gly Ala Asp Pro Ala Thr

135 140145ttg gta ctg gtc ggc atg gct atc act gcc ttt ttg ggt gct gtt att 595Leu Val Leu Val Gly Met Ala Ile Thr Ala Phe Leu Gly Ala Val Ile150 155 160 165tcc agc gcc act gcg aac gca cca caa gat tct gag ctt cga tcc gtg 643Ser Ser Ala Thr Ala Asn Ala Pro Gln Asp Ser Glu Leu Arg Ser Val

170 175 180acg ttt tgg ctc aac ggc gat ctg gta tct cgg acg tgg gaa cat gtg 691Thr Phe Trp Leu Asn Gly Asp Leu Val Ser Arg Thr Trp Glu His Val

185 190 195ggc gtt gca ata atc ccc att atc gtt ggg ttg att cta gct atc ggc 739Gly Val Ala Ile Ile Pro Ile Ile Val Gly Leu Ile Leu Ala Ile Gly

200 205 210ggt tcc cgc gat ctg aac ttg ttg ctg ctg ggt gat tcc aca gcg caa 787Gly Ser Arg Asp Leu Asn Leu Leu Leu Leu Gly Asp Ser Thr Ala Gln

215 220 225aca tct gga ctc aac gtc aac cgc gca cgc atc att ttg cta gca ctt 835Thr Ser Gly Leu Asn Val Asn Arg Ala Arg Ile Ile Leu Leu Ala Leu230 235 240 245gcg gca ctg ctc acc gcc aca gct gtt gcg gtc tcc ggc acc att acg 883Ala Ala Leu Leu Thr Ala Thr Ala Val Ala Val Ser Gly Thr Ile Thr

250 255 260ttt gtt gga ttg gta gta ccc cac ctg gtg cgc att gtt tta ggt gcc 931Phe Val Gly Leu Val Val Pro His Leu Val Arg Ile Val Leu Gly Ala

265 270 275gat cac cga gcg tta ctc ccg gcc gcc gcg att ttg ggc gcc acg ttt 979Asp His Arg Ala Leu Leu Pro Ala Ala Ala Ile Leu Gly Ala Thr Phe

280 285 290gtt atc gtt tcc gac act gtt gcc cgc atg atc ttc tcc ccc atc gtc 1027Val Ile Val Ser Asp Thr Val Ala Arg Met Ile Phe Ser Pro Ile Val

295 300 305ttg caa aca ggc gtg gtg gtg gcg ttc att ggc tca cca att ttc ctt 1075Leu Gln Thr Gly Val Val Val Ala Phe Ile Gly Ser Pro Ile Phe Leu310 315 320 325tat tta ctg ctc agc atg cgc aag cga cgc gga ttg ggg ctg 1117Tyr Leu Leu Leu Ser Met Arg Lys Arg Arg Gly Leu Gly Leu

330335 taaaaactca tgcctcaatt agt 1140<210>492<211>339<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>492Leu Ser Arg Thr Gly Val Ser Lys Lys Pro Lys Leu Thr Ala Pro Val 151015 Val Ile Ile Gly Thr Leu Val Leu Leu Ile Ile Ala Phe Thr Ala Ser

20 25 30Leu Met Leu Gly Pro Val Thr Val Pro Leu Asn Glu Leu Ala Thr Asn

35 40 45Pro Val Val Thr Asp Ile Arg Ala Pro Arg Ile Ile Ile Ala Ala Leu

50 55 60Val Gly Ala Ala Leu Ala Val Ser Gly Ala Ile Met Gln Thr Val Phe 65 70 75 80His Asn Pro Leu Ala Asp Pro Gly Ile Val Gly Val Ser Ser Gly Ala

85 90 95Ala Val Ala Ala Val Leu Ala Ile Val Thr Gly Ala Ser Phe Phe Gly

100 105 110Gln Trp Thr Val Pro Phe Ala Ala Phe Val Gly Ala Leu Val Thr Val

115 120 125Ala Val Val Tyr Leu Ile Ala Ser Ser Arg Ala Met Asp Gly Arg Gly

130 135 140Ala Asp Pro Ala Thr Leu Val Leu Val Gly Met Ala Ile Thr Ala Phe145 150 155 160Leu Gly Ala Val Ile Ser Ser Ala Thr Ala Asn Ala Pro Gln Asp Ser

165 170 175Glu Leu Arg Ser Val Thr Phe Trp Leu Asn Gly Asp Leu Val Ser Arg

180 185 190Thr Trp Glu His Val Gly Val Ala Ile Ile Pro Ile Ile Val Gly Leu

195 200 205Ile Leu Ala Ile Gly Gly Ser Arg Asp Leu Asn Leu Leu Leu Leu Gly

210 215 220Asp Ser Thr Ala Gln Thr Ser Gly Leu Asn Val Asn Arg Ala Arg Ile225 230 235 240Ile Leu Leu Ala Leu Ala Ala Leu Leu Thr Ala Thr Ala Val Ala Val

245 250 255Ser Gly Thr Ile Thr Phe Val Gly Leu Val Val Pro His Leu Val Arg

260 265 270Ile Val Leu Gly Ala Asp His Arg Ala Leu Leu Pro Ala Ala Ala Ile

275 280 285Leu Gly Ala Thr Phe Val Ile Val Ser Asp Thr Val Ala Arg Met Ile

290 295 300Phe Ser Pro Ile Val Leu Gln Thr Gly Val Val Val Ala Phe Ile Gly305 310 315 320Ser Pro Ile Phe Leu Tyr Leu Leu Leu Ser Met Arg Lys Arg Arg Gly

325330335 Leu Gly Leu<210>493<211>1140<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1117)<223>FRXA02865<400>493gagcggggtt gctatcggcc gaaagtttag ggttttgttc aatctgttgg ttagtattgc 60ttgggtaaac aagtcataac aattttcatt aagggtcgtt ttg tcg cgc aca ggt 115

Leu Ser Arg Thr Gly

1 5gtt tcg aaa aaa cca aag ctc acc gct cct gtt gtc atc atc ggc acc 163Val Ser Lys Lys Pro Lys Leu Thr Ala Pro Val Val Ile Ile Gly Thr

10 15 20ctc gtc ttg ttg atc atc gcc ttc acc gct tcc ctc atg ctg ggt ccc 211Leu Val Leu Leu Ile Ile Ala Phe Thr Ala Ser Leu Met Leu Gly Pro

25 30 35gtg acg gtt cca ttg aat gag ctt gca acc aac ccc gtt gtc acc gat 259Val Thr Val Pro Leu Asn Glu Leu Ala Thr Asn Pro Val Val Thr Asp

40 45 50atc cgt gca cca cgc att atc atc gca gca ttg gtg ggt gcg gcg ctg 307Ile Arg Ala Pro Arg Ile Ile Ile Ala Ala Leu Val Gly Ala Ala Leu

55 60 65gct gtc tcc ggt gcg atc atg cag acg gtg ttt cac aac ccg ttg gcg 355Ala Val Ser Gly Ala Ile Met Gln Thr Val Phe His Asn Pro Leu Ala 70 75 80 85gat ccc ggc att gtg ggt gtg tcc tcc ggt gca gct gtt gca gct gtc 403Asp Pro Gly Ile Val Gly Val Ser Ser Gly Ala Ala Val Ala Ala Val

90 95 100ttg gcg att gtc acc ggt gcg agt ttc ttt ggc caa tgg acc gtt cct 451Leu Ala Ile Val Thr Gly Ala Ser Phe Phe Gly Gln Trp Thr Val Pro

105 110 115ttt gcg gcc ttc gtg ggc gca ttg gtc acg gtg gct gtg gta tat ttg 499Phe Ala Ala Phe Val Gly Ala Leu Val Thr Val Ala Val Val Tyr Leu

120 125 130atc gct agt tcc cgc gcg atg gat ggc cgt ggc gca gat ccg gcc acg 547Ile Ala Ser Ser Arg Ala Met Asp Gly Arg Gly Ala Asp Pro Ala Thr

135 140 145ttg gta ctg gtc ggc atg gct atc act gcc ttt ttg ggt gct gtt att 595Leu Val Leu Val Gly Met Ala Ile Thr Ala Phe Leu Gly Ala Val Ile150 155 160 165tcc agc gcc act gcg aac gca cca caa gat tct gag ctt cga tcc gtg 643Ser Ser Ala Thr Ala Asn Ala Pro Gln Asp Ser Glu Leu Arg Ser Val

170 175 180acg ttt tgg ctc aac ggc gat ctg gta tct cgg acg tgg gaa cat gtg 691Thr Phe Trp Leu Asn Gly Asp Leu Val Ser Arg Thr Trp Glu His Val

185 190 195ggc gtt gca ata atc ccc att atc gtt ggg ttg att cta gct atc ggc 739Gly Val Ala Ile Ile Pro Ile Ile Val Gly Leu Ile Leu Ala Ile Gly

200 205 210ggt tcc cgc gat ctg aac ttg ttg ctg ctg ggt gat tcc aca gcg caa 787Gly Ser Arg Asp Leu Asn Leu Leu Leu Leu Gly Asp Ser Thr Ala Gln

215 220 225aca tct gga ctc aac gtc aac cgc gca cgc atc att ttg cta gca ctt 835Thr Ser Gly Leu Asn Val Asn Arg Ala Arg Ile Ile Leu Leu Ala Leu230 235 240 245gcg gca ctg ctc acc gcc aca gct gtt gcg gtc tcc ggc acc att acg 883Ala Ala Leu Leu Thr Ala Thr Ala Val Ala Val Ser Gly Thr Ile Thr

250 255 260ttt gtt gga ttg gta gta ccc cac ctg gtg cgc att gtt tta ggt gcc 931Phe Val Gly Leu Val Val Pro His Leu Val Arg Ile Val Leu Gly Ala

265 270 275gat cac cga gcg tta ctc ccg gcc gcc gcg att ttg ggc gcc acg ttt 979Asp His Arg Ala Leu Leu Pro Ala Ala Ala Ile Leu Gly Ala Thr Phe

280 285 290gtt atc gtt tcc gac act gtt gcc cgc atg atc ttc tcc ccc atc gtc 1027Val Ile Val Ser Asp Thr Val Ala Arg Met Ile Phe Ser Pro Ile Val

295 300 305ttg caa aca ggc gtg gtg gtg gcg ttc att ggc tca cca att ttc ctt 1075Leu Gln Thr Gly Val Val Val Ala Phe Ile Gly Ser Pro Ile Phe Leu310 315 320 325tat tta ctg ctc agc atg cgc aag cga cgc gga ttg ggg ctg 1117Tyr Leu Leu Leu Ser Met Arg Lys Arg Arg Gly Leu Gly Leu

330335 taaaaactca tgcctcaatt agt 1140<210>494<211>339<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>494Leu Ser Arg Thr Gly Val Ser Lys Lys Pro Lys Leu Thr Ala Pro Val 151015 Val Ile Ile Gly Thr Leu Val Leu Leu Ile Ile Ala Phe Thr Ala Ser

20 25 30Leu Met Leu Gly Pro Val Thr Val Pro Leu Asn Glu Leu Ala Thr Asn

35 40 45Pro Val Val Thr Asp Ile Arg Ala Pro Arg Ile Ile Ile Ala Ala Leu

50 55 60Val Gly Ala Ala Leu Ala Val Ser Gly Ala Ile Met Gln Thr Val Phe65 70 75 80His Asn Pro Leu Ala Asp Pro Gly Ile Val Gly Val Ser Ser Gly Ala

85 90 95Ala Val Ala Ala Val Leu Ala Ile Val Thr Gly Ala Ser Phe Phe Gly

100 105 110Gln Trp Thr Val Pro Phe Ala Ala Phe Val Gly Ala Leu Val Thr Val

115 120 125Ala Val Val Tyr Leu Ile Ala Ser Ser Arg Ala Met Asp Gly Arg Gly

130 135 140Ala Asp Pro Ala Thr Leu Val Leu Val Gly Met Ala Ile Thr Ala Phe145 150 155 160Leu Gly Ala Val Ile Ser Ser Ala Thr Ala Asn Ala Pro Gln Asp Ser

165 170 175Glu Leu Arg Ser Val Thr Phe Trp Leu Asn Gly Asp Leu Val Ser Arg

180 185 190Thr Trp Glu His Val Gly Val Ala Ile Ile Pro Ile Ile Val Gly Leu

195 200 205Ile Leu Ala Ile Gly Gly Ser Arg Asp Leu Asn Leu Leu Leu Leu Gly

210 215 220Asp Ser Thr Ala Gln Thr Ser Gly Leu Asn Val Asn Arg Ala Arg Ile225 230 235 240Ile Leu Leu Ala Leu Ala Ala Leu Leu Thr Ala Thr Ala Val Ala Val

245 250 255Ser Gly Thr Ile Thr Phe Val Gly Leu Val Val Pro His Leu Val Arg

260 265 270Ile Val Leu Gly Ala Asp His Arg Ala Leu Leu Pro Ala Ala Ala Ile

275 280 285Leu Gly Ala Thr Phe Val Ile Val Ser Asp Thr Val Ala Arg Met Ile

290 295 300Phe Ser Pro Ile Val Leu Gln Thr Gly Val Val Val Ala Phe Ile Gly305 310 315 320Ser Pro Ile Phe Leu Tyr Leu Leu Leu Ser Met Arg Lys Arg Arg Gly

325330335 Leu Gly Leu<210>495<211>1695<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1672)<223>RXA00181<400>495gtatattcag acacccacgt cgattagtgt tgtagttcac agtgcttatt ttttatttgt 60atctttgcac gtttgtcccc tacccaaaag gagaaacctc atg agc gat aac acc 115

Met Ser Asp Asn Thr

1 5tgg ttc atc ata gcc atc gtt atc tat atg ttg gtg atg gtg ctc atc 163Trp Phe Ile Ile Ala Ile Val Ile Tyr Met Leu Val Met Val Leu Ile

10 15 20ggc tat tgg agt tac cgc aag aca gaa aaa tac gac gac tac atg ctc 211Gly Tyr Trp Ser Tyr Arg Lys Thr Glu Lys Tyr Asp Asp Tyr Met Leu

25 30 35gcc ggc cgc ggg ctc aac cct ttt gtt gcc gca atg tcc gca ggt gcc 259Ala Gly Arg Gly Leu Asn Pro Phe Val Ala Ala Met Ser Ala Gly Ala

40 45 50tca gat atg tca ggt tgg ctg ctc atg ggt ctg ccc ggc gcg ctg ttt 307Ser Asp Met Ser Gly Trp Leu Leu Met Gly Leu Pro Gly Ala Leu Phe

55 60 65gtc acc ggc atg tcc gag ttg tgg atc gca gtc gga ctc acc att ggt 355Val Thr Gly Met Ser Glu Leu Trp Ile Ala Val Gly Leu Thr Ile Gly 70 75 80 85gca tgg gcg aac tgg atg tgg gtg gca cct cgt ctt cgt tct tat tcc 403Ala Trp Ala Asn Trp Met Trp Val Ala Pro Arg Leu Arg Ser Tyr Ser

90 95 100gaa atc tcg gcc aac tca atc acc ctg cct tca ttc ttt gag aac cga 451Glu Ile Ser Ala Asn Ser Ile Thr Leu Pro Ser Phe Phe Glu Asn Arg

105 110 115ctt cgc gat aaa tct cgc gcg ctt cgc atc att gca gca cta att atc 499Leu Arg Asp Lys Ser Arg Ala Leu Arg Ile Ile Ala Ala Leu Ile Ile

120 125 130att gtg ttc ttc acc ttc tac att tct tca ggc atg gtt gct ggt gga 547Ile Val Phe Phe Thr Phe Tyr Ile Ser Ser Gly Met Val Ala Gly Gly

135 140 145gtg tat tgg gag tcc acg ttt ggt gga gat tat cta ctc ggt atg gcc 595Val Tyr Trp Glu Ser Thr Phe Gly Gly AspTyr Leu Leu Gly Met Ala150 155 160 165att gtc gca ggt gtg aca gtg ctg tat acc ttc att gga gga ttc ctt 643Ile Val Ala Gly Val Thr Val Leu Tyr Thr Phe Ile Gly Gly Phe Leu

170 175 180gct gtg tct tat aca gac gca gtt cag ggg act atc atg ttc ttc tcg 691Ala Val Ser Tyr Thr Asp Ala Val Gln Gly Thr Ile Met Phe Phe Ser

185 190 195ttg atc atc gtg cca gtc atg gca tat ttc gca ctg gcg aac ccc atg 739Leu Ile Ile Val Pro Val Met Ala Tyr Phe Ala Leu Ala Asn Pro Met

200 205 210gat att tgg agc ttt gca aac tct aat gat tac ggc ccg cac acc gat 787Asp Ile Trp Ser Phe Ala Asn Ser Asn Asp Tyr Gly Pro His Thr Asp

215 220 225gga att ggc aat ccc acc tac ttc tcc atg atc agt ggc att tct gca 835Gly Ile Gly Asn Pro Thr Tyr Phe Ser Met Ile Ser Gly Ile Ser Ala230 235 240 245gca gca atc att ggt aac tta ggt tgg ggt ctt gga tac ttc ggc cag 883Ala Ala Ile Ile Gly Asn Leu Gly Trp Gly Leu Gly Tyr Phe Gly Gln

250 255 260cca cac att gtg gtt cgt ttc atg gca ctt cgc aca cca gct gaa gca 931Pro His Ile Val Val Arg Phe Met Ala Leu Arg Thr Pro Ala Glu Ala

265 270 275aag caa ggt cgt cgc atc ggt att tcc tgg atg ata atc tgc ctg att 979Lys Gln Gly Arg Arg Ile Gly Ile Ser Trp Met Ile Ile Cys Leu Ile

280 285 290ggt gca acc ttt acc gca att atc tcc aca gtt ttc ttt gca caa aac 1027Gly Ala Thr Phe Thr Ala Ile Ile Ser Thr Val Phe Phe Ala Gln Asn

295 300305ccc gac gcc aac atc act gac aca agg gct tat gag tcc atc ttc cta 1075Pro Asp Ala Asn Ile Thr Asp Thr Arg Ala Tyr Glu Ser Ile Phe Leu310 315 320 325gat ctt gcc cgg atg ctg ttc cac cca ttg atc gct gga ctt att ctg 1123Asp Leu Ala Arg Met Leu Phe His Pro Leu Ile Ala Gly Leu Ile Leu

330 335 340act gct gtt ctc gcg gcc atc atg tct acc atg tcg tca cag ctg ctg 1171Thr Ala Val Leu Ala Ala Ile Met Ser Thr Met Ser Ser Gln Leu Leu

345 350 355gtc acc gca tct tcc ctg att gag gac ctg ctg aag gta gtt aaa aag 1219Val Thr Ala Ser Ser Leu Ile Glu Asp Leu Leu Lys Val Val Lys Lys

360 365 370gac tcg ctg agc gaa cgc acc ctg atc atg ctg tct cgt gcc aca gtc 1267Asp Ser Leu Ser Glu Arg Thr Leu Ile Met Leu Ser Arg Ala Thr Val

375 380 385atc att ctg gcg atc att gca gca gcc atg gct att aac ccg tct gat 1315Ile Ile Leu Ala Ile Ile Ala Ala Ala Met Ala Ile Asn Pro Ser Asp390 395 400 405tcc atc ctc gga ttg gtg gga ttt gcg tgg gca gga ttc ggc tct gca 1363Ser Ile Leu Gly Leu Val Gly Phe Ala Trp Ala Gly Phe Gly Ser Ala

410 415 420ttt ggt ccg atc ata ctt gct agc ctt tat tgg aag cgt ctc aac gcc 1411Phe Gly Pro Ile Ile Leu Ala Ser Leu Tyr Trp Lys Arg Leu Asn Ala

425 430 435gcc ggc gct atc tcc ggc atg att act ggt gct att gtc tcc atc gcg 1459Ala Gly Ala Ile Ser Gly Met Ile Thr Gly Ala Ile Val Ser Ile Ala

440 445 450tgg ggt atg tcc cca cta agc gat acg ttg tat gaa atc atc cca ggt 1507Trp Gly Met Ser Pro Leu Ser Asp Thr Leu Tyr Glu Ile Ile Pro Gly

455 460 465ttc gcc ttg gca acc atc gtg atg gtc gtt gtt tcc ctc ctg aca aag 1555Phe Ala Leu Ala Thr Ile Val Met Val Val Val Ser Leu Leu Thr Lys470 475 480 485gaa ccc tcc gaa gaa atc ctc aac gag ttt gaa acc gcc aag gat ctt 1603Glu Pro Ser Glu Glu Ile Leu Asn Glu Phe Glu Thr Ala Lys Asp Leu

490 495 500gct gcc gct gtg gaa tca aac gag gat gtt gat ttc gct gac gca gct 1651Ala Ala Ala Val Glu Ser Asn Glu Asp Val Asp Phe Ala Asp Ala Ala

505 510 515cag aag ctt tcg aaa gaa agt taagccttag agggaaccaa acg 1695Gln Lys Leu Ser Lys Glu Ser

520<210>496<211>524<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>496Met Ser Asp Asn Thr Trp Phe Ile Ile Ala Ile Val Ile Tyr Met Leu 151015 Val Met Val Leu Ile Gly Tyr Trp Ser Tyr Arg Lys Thr Glu Lys Tyr

20 25 30Asp Asp Tyr Met Leu Ala Gly Arg Gly Leu Asn Pro Phe Val Ala Ala

35 40 45Met Ser Ala Gly Ala Ser Asp Met Ser Gly Trp Leu Leu Met Gly Leu

50 55 60Pro Gly Ala Leu Phe Val Thr Gly Met Ser Glu Leu Trp Ile Ala Val 65 70 75 80Gly Leu Thr Ile Gly Ala Trp Ala Asn Trp Met Trp Val Ala Pro Arg

85 90 95Leu Arg Ser Tyr Ser Glu Ile Ser Ala Asn Ser Ile Thr Leu Pro Ser

100 105 110Phe Phe Glu Asn Arg Leu Arg Asp Lys Ser Arg Ala Leu Arg Ile Ile

115 120 125Ala Ala Leu Ile Ile Ile Val Phe Phe Thr Phe Tyr Ile Ser Ser Gly

130 135 140Met Val Ala Gly Gly Val Tyr Trp Glu Ser Thr Phe Gly Gly Asp Tyr145 150 155 160Leu Leu Gly Met Ala Ile Val Ala Gly Val Thr Val Leu Tyr Thr Phe

165 170 175Ile Gly Gly Phe Leu Ala Val Ser Tyr Thr Asp Ala Val Gln Gly Thr

180 185 190Ile Met Phe Phe Ser Leu Ile Ile Val Pro Val Met Ala Tyr Phe Ala

195 200 205Leu Ala Asn Pro Met Asp Ile Trp Ser Phe Ala Asn Ser Asn Asp Tyr

210 215 220Gly Pro His Thr Asp Gly Ile Gly Asn Pro Thr Tyr Phe Ser Met Ile225 230 235 240Ser Gly Ile Ser Ala Ala Ala Ile Ile Gly Asn Leu Gly Trp Gly Leu

245 250 255Gly Tyr Phe Gly Gln Pro His Ile Val Val Arg Phe Met Ala Leu Arg

260 265 270Thr Pro Ala Glu Ala Lys Gln Gly Arg Arg Ile Gly Ile Ser Trp Met

275 280 285Ile Ile Cys Leu Ile Gly Ala Thr Phe Thr Ala Ile Ile Ser Thr Val

290 295 300Phe Phe Ala Gln Asn Pro Asp Ala Asn Ile Thr Asp Thr Arg Ala Tyr305 310 315 320Glu Ser Ile Phe Leu Asp Leu Ala Arg Met Leu Phe His Pro Leu Ile

325 330 335Ala Gly Leu Ile Leu Thr Ala Val Leu Ala Ala Ile Met Ser Thr Met

340 345 350Ser Ser Gln Leu Leu Val Thr Ala Ser Ser Leu Ile Glu Asp Leu Leu

355 360 365Lys Val Val Lys Lys Asp Ser Leu Ser Glu Arg Thr Leu Ile Met Leu

370 375 380Ser Arg Ala Thr Val Ile Ile Leu Ala Ile Ile Ala Ala Ala Met Ala385 390 395 400Ile Asn Pro Ser Asp Ser Ile Leu Gly Leu Val Gly Phe Ala Trp Ala

405 410 415Gly Phe Gly Ser Ala Phe Gly Pro Ile Ile Leu Ala Ser Leu Tyr Trp

420 425 430Lys Arg Leu Asn Ala Ala Gly Ala Ile Ser Gly Met Ile Thr Gly Ala

435 440 445Ile Val Ser Ile Ala Trp Gly Met Ser Pro Leu Ser Asp Thr Leu Tyr

450 455 460Glu Ile Ile Pro Gly Phe Ala Leu Ala Thr Ile Val Met Val Val Val465 470 475 480Ser Leu Leu Thr Lys Glu Pro Ser Glu Glu Ile Leu Asn Glu Phe Glu

485 490 495Thr Ala Lys Asp Leu Ala Ala Ala Val Glu Ser Asn Glu Asp Val Asp

500 505 510Phe Ala Asp Ala Ala Gln Lys Leu Ser Lys Glu Ser

515520<210>497<211>1476<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1453)<223>RXA00591<400>497gcaacgccac aggcaaaatc caaaagaaca tcctgcgaga cttcaccatc cccgtttcat 60aaacccccca acgtcacttt gaaaacactt ggagaacgca atg act aca tct tcc 115

Met Thr ThrSer Ser

1 5aca gct tcg ccg atc gct gaa tta caa aac ctc agc ccg aag caa aga 163Thr Ala Ser Pro Ile Ala Glu Leu Gln Asn Leu Ser Pro Lys Gln Arg

10 15 20aaa tca gaa tcc cgg cgc gcg att ata tcc agc tac ttg ggc tcc acg 211Lys Ser Glu Ser Arg Arg Ala Ile Ile Ser Ser Tyr Leu Gly Ser Thr

25 30 35atc gag ttc tat gac ttc ctg tta tat gcc gca gcc tcc gcg acg gta 259Ile Glu Phe Tyr Asp Phe Leu Leu Tyr Ala Ala Ala Ser Ala Thr Val

40 45 50ttc ccc gca gtg ttc ttt acc aat ctc gat ccg ctg gct gga acc att 307Phe Pro Ala Val Phe Phe Thr Asn Leu Asp Pro Leu Ala Gly Thr Ile

55 60 65gcc gcc tac gga acc ttc gcc gca ggt tat tta gct agg cca ctt ggt 355Ala Ala Tyr Gly Thr Phe Ala Ala Gly Tyr Leu Ala Arg Pro Leu Gly70 75 80 85gga gca atc ttc gga cac ttc ggt gac cgt ctt gga cgc aag aag atg 403Gly Ala Ile Phe Gly His Phe Gly Asp Arg Leu Gly Arg Lys Lys Met

90 95 100ctt gtg ttg tcc atg ctc atc atg ggt gtg gca tcc aca tgc atc ggc 451Leu Val Leu Ser Met Leu Ile Met Gly Val Ala Ser Thr Cys Ile Gly

105 110 115ctt gtc cca agc gct gaa atg atc gga agc atg ggc gcg gta atc ctg 499Leu Val Pro Ser Ala Glu Met Ile Gly Ser Met Gly Ala Val Ile Leu

120 125 130atc atg ctg cgc atc tgc caa ggc atc gct gtc ggt ggc gaa tgg ggc 547Ile Met Leu Arg Ile Cys Gln Gly Ile Ala Val Gly Gly Glu Trp Gly

135 140145gga gct gcc ctc atg gcg ctc gag cac tca gat tcc aag aag cgc gga 595Gly Ala Ala Leu Met Ala Leu Glu His Ser Asp Ser Lys Lys Arg Gly150 155 160 165ttc gcc gcc tcc ttc acc aac gct ggt gca cca acc ggc gct gca ctg 643Phe Ala Ala Ser Phe Thr Asn Ala Gly Ala Pro Thr Gly Ala Ala Leu

170 175 180gga acc ttc gcg ctc ggt acc gca tct gct gtt ctc acc cag gag caa 691Gly Thr Phe Ala Leu Gly Thr Ala Ser Ala Val Leu Thr Gln Glu Gln

185 190 195ttc ctt tca tgg ggt tgg cgc atc cca ttc ctg ctc tct ttc gtt ctg 739Phe Leu Ser Trp Gly Trp Arg Ile Pro Phe Leu Leu Ser Phe Val Leu

200 205 210ctg att gtc ggc ttg gtt atc cgc gcg aaa gtt agc gaa tca cca ctg 787Leu Ile Val Gly Leu Val Ile Arg Ala Lys Val Ser Glu Ser Pro Leu

215 220 225ttc gca gct gca gcg gcc gcc gaa aaa gcc aag cca acc gaa cgt aaa 835Phe Ala Ala Ala Ala Ala Ala Glu Lys Ala Lys Pro Thr Glu Arg Lys230 235 240 245gtc ccc ctc ttg cag gtt ctt cgc cga cca aag gca ctg atc ttg acc 883Val Pro Leu Leu Gln Val Leu Arg Arg Pro Lys Ala Leu Ile Leu Thr

250 255 260atg ctt ggc ggc gca tca gga ttc gga ctt caa gtt ctc ttg tcc acc 931Met Leu Gly Gly Ala Ser Gly Phe Gly Leu Gln Val Leu Leu Ser Thr

265 270 275ttc tcc atc agc tac gca aca caa tcc ggc atc gaa aga tcc agc gtc 979Phe Ser Ile Ser Tyr Ala Thr Gln Ser Gly Ile Glu Arg Ser Ser Val

280 285 290ctc tac gcc ttc gca gtc gcc tca gtg ttc tct gtc ttc ttt gtg atc 1027Leu Tyr Ala Phe Ala Val Ala Ser Val Phe Ser Val Phe Phe Val Ile

295 300 305ctc ttc ggt cgc gta tcc gac ctc ttc gga cgc cga ccc gtc atg atc 1075Leu Phe Gly Arg Val Ser Asp Leu Phe Gly Arg Arg Pro Val Met Ile310 315 320 325atc gcg ctc gta ctg ttc gtg gcc tac ctg ccg gca ttc ttc cgg atg 1123Ile Ala Leu Val Leu Phe Val Ala Tyr Leu Pro Ala Phe Phe Arg Met

330 335 340ctc acc tca gac aac tgg ttc ate ctg ctc tcg gca ttc acc atc gcg 1171Leu Thr Ser Asp Asn Trp Phe Ile Leu Leu Ser Ala Phe Thr Ile Ala

345 350 355ctc gca ctc cac gcc atg ctt tac ggc cca cta gca gcg ttt atc tcc 1219Leu Ala Leu His Ala Met Leu Tyr Gly Pro Leu Ala Ala Phe Ile Ser

360 365 370gaa caa ttc gga acc tcc gcg cgc tac aca ggc gca tcc ctg ggt tac 1267Glu Gln Phe Gly Thr Ser Ala Arg Tyr Thr Gly Ala Ser Leu Gly Tyr

375 380 385cag ttg gcc acg ctc atc ggt gca gga ttc acc cca acc atc ctg gct 1315Gln Leu Ala Thr Leu Ile Gly Ala Gly Phe Thr Pro Thr Ile Leu Ala390 395 400 405agc ctc tac gcg gga cca ggc ggc gga acc tct gtc acc cca gtc atc 1363Ser Leu Tyr Ala Gly Pro Gly Gly Gly Thr Ser Val Thr Pro Val Ile

410 415 420gtc ttc ctc gca acg atg tcc cta gtg tcc atc atc gcc atc gca atc 1411Val Phe Leu Ala Thr Met Ser Leu Val Ser Ile Ile Ala Ile Ala Ile

425 430 435acc aga gaa tca aaa gac cac gat ctt tct act tac gaa cac 1453Thr Arg Glu Ser Lys Asp His Asp Leu Ser Thr Tyr Glu His

440445450 taaggggacg atagggtcaa ttt 1476<210>498<211>451<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>498Met Thr Thr Ser Ser Thr Ala Ser Pro Ile Ala Glu Leu Gln Asn Leu 151015 Ser Pro Lys Gln Arg Lys Ser Glu Ser Arg Arg Ala Ile Ile Ser Ser

20 25 30Tyr Leu Gly Ser Thr Ile Glu Phe Tyr Asp Phe Leu Leu Tyr Ala Ala

35 40 45Ala Ser Ala Thr Val Phe Pro Ala Val Phe Phe Thr Asn Leu Asp Pro

50 55 60Leu Ala Gly Thr Ile Ala Ala Tyr Gly Thr Phe Ala Ala Gly Tyr Leu 65 70 75 80Ala Arg Pro Leu Gly Gly Ala Ile Phe Gly His Phe Gly Asp Arg Leu

85 90 95Gly Arg Lys Lys Met Leu Val Leu Ser Met Leu Ile Met Gly Val Ala

100 105 110Ser Thr Cys Ile Gly Leu Val Pro Ser Ala Glu Met Ile Gly Ser Met

115 120 125Gly Ala Val Ile Leu Ile Met Leu Arg Ile Cys Gln Gly Ile Ala Val

130 135 140Gly Gly Glu Trp Gly Gly Ala Ala Leu Met Ala Leu Glu His Ser Asp145 150 155 160Ser Lys Lys Arg Gly Phe Ala Ala Ser Phe Thr Asn Ala Gly Ala Pro

165 170 175Thr Gly Ala Ala Leu Gly Thr Phe Ala Leu Gly Thr Ala Ser Ala Val

180 185 190Leu Thr Gln Glu Gln Phe Leu Ser Trp Gly Trp Arg Ile Pro Phe Leu

195 200 205Leu Ser Phe Val Leu Leu Ile Val Gly Leu Val Ile Arg Ala Lys Val

210 215 220Ser Glu Ser Pro Leu Phe Ala Ala Ala Ala Ala Ala Glu Lys Ala Lys225 230 235 240Pro Thr Glu Arg Lys Val Pro Leu Leu Gln Val Leu Arg Arg Pro Lys

245 250 255Ala Leu Ile Leu Thr Met Leu Gly Gly Ala Ser Gly Phe Gly Leu Gln

260 265 270Val Leu Leu Ser Thr Phe Ser Ile Ser Tyr Ala Thr Gln Ser Gly Ile

275 280 285Glu Arg Ser Ser Val Leu Tyr Ala Phe Ala Val Ala Ser Val Phe Ser

290 295 300Val Phe Phe Val Ile Leu Phe Gly Arg Val Ser Asp Leu Phe Gly Arg305 310 315 320Arg Pro Val Met Ile Ile Ala Leu Val Leu Phe Val Ala Tyr Leu Pro

325 330 335Ala Phe Phe Arg Met Leu Thr Ser Asp Asn Trp Phe Ile Leu Leu Ser

340 345 350Ala Phe Thr Ile Ala Leu Ala Leu His Ala Met Leu Tyr Gly Pro Leu

355 360 365Ala Ala Phe Ile Ser Glu Gln Phe Gly Thr Ser Ala Arg Tyr Thr Gly

370 375 380Ala Ser Leu Gly Tyr Gln Leu Ala Thr Leu Ile Gly Ala Gly Phe Thr385 390 395 400Pro Thr Ile Leu Ala Ser Leu Tyr Ala Gly Pro Gly Gly Gly Thr Ser

405 410 415Val Thr Pro Val Ile Val Phe Leu Ala Thr Met Ser Leu Val Ser Ile

420 425 430Ile Ala Ile Ala Ile Thr Arg Glu Ser Lys Asp His Asp Leu Ser Thr

435 440 445Tyr Glu His

450<210>499<211>1635<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). - (1612)<223>RXA01629<400>499caggaagaag ttaacaccgc ccaggggtgc gttggatgat gatcatctac aaacaaacat 60tccgttatgc actcataaga tatgacgaga ggttttactc gtg agc ccg att cgc 115

Val Ser Pro Ile Arg

1 5tca aaa aag aaa atc aag aac gaa cca aga cta aca gtc gat gac gtc 163Ser Lys Lys Lys Ile Lys Asn Glu Pro Arg Leu Thr Val Asp Asp Val

10 15 20aac gtt gtt ccc cca aag aag atc cgt ccg gcc att aaa ggc act gtg 211Asn Val Val Pro Pro Lys Lys Ile Arg Pro Ala Ile Lys Gly Thr Val

25 30 35gtg ggt aac ttc atg gag tgg tac gac ttc gga att tat ggt tat ttg 259Val Gly Asn Phe Met Glu Trp Tyr Asp Phe Gly Ile Tyr Gly Tyr Leu

40 45 50acg gtc acg atg acc gca gta ttt acc caa ggc ctg ccg caa gaa tgg 307Thr Val Thr Met Thr Ala Val Phe Thr Gln Gly Leu Pro Gln Glu Trp

55 60 65cag ttg ttg gcc gtg atg ttt ggt ttc gcg gtg tct tat tta gtt cgc 355Gln Leu Leu Ala Val Met Phe Gly Phe Ala Val Ser Tyr Leu Val Arg 70 75 80 85ccg ctt ggt ggc ctg gtt ctg ggt ccg ctt ggc gat aag gtt ggc cgc 403Pro Leu Gly Gly Leu Val Leu Gly Pro Leu Gly Asp Lys Val Gly Arg

90 95 100cag aag gtt ttg tac gta acc atg gcc atg atg gcc gtg tct acg gcg 451Gln Lys Val LeuTyr Val Thr Met Ala Met Met Ala Val Ser Thr Ala

105 110 115ctg att ggc ttg ctg ccg acg gcg gcg tcg ata ggc gct tgg gct ttg 499Leu Ile Gly Leu Leu Pro Thr Ala Ala Ser Ile Gly Ala Trp Ala Leu

120 125 130gtg ctt ttg tac ctg ttg aag atg gtg cag gga ttt tcg act ggt ggt 547Val Leu Leu Tyr Leu Leu Lys Met Val Gln Gly Phe Ser Thr Gly Gly

135 140 145gaa tat gct ggt gcg acc acc tat gtt gct gag ttt gcg ccg gat cgt 595Glu Tyr Ala Gly Ala Thr Thr Tyr Val Ala Glu Phe Ala Pro Asp Arg150 155 160 165cga cga ggt ttc ttc gga gct ttc eta gat atg ggt tcc tac ctg ggc 643Arg Arg Gly Phe Phe Gly Ala Phe Leu Asp Met Gly Ser Tyr Leu Gly

170 175 180ttt gcc gcg ggt gct tcg gtc gtg gcg att act acc tgg gtg acc act 691Phe Ala Ala Gly Ala Ser Val Val Ala Ile Thr Thr Trp Val Thr Thr

185 190 195cac ttc tat ggc gca act gcc atg gag gat ttc ggt tgg cgt att cct 739His Phe Tyr Gly Ala Thr Ala Met Glu Asp Phe Gly Trp Arg Ile Pro

200 205 210ttc ctg act gcg atc ccg ctg ggc atc att gcg gtg tac ctg cgt act 787Phe Leu Thr Ala Ile Pro Leu Gly Ile Ile Ala Val Tyr Leu Arg Thr

215 220 225cgt atc cct gag acc cct gcg ttt gag aac aac caa gac gag cca aat 835Arg Ile Pro Glu Thr Pro Ala Phe Glu Asn Asn Gln Asp Glu Pro Asn230 235 240 245gca gtt gtt gaa aag gac act gaa gat cct tat gca cgc ctg ggc ctg 883Ala Val Val Glu Lys Asp Thr Glu Asp Pro Tyr Ala Arg Leu Gly Leu

250 255 260gct ggt gtt atc cgc cac cac tgg cgt cca ctg ctg att ggt att gcg 931Ala Gly Val Ile Arg His His Trp Arg Pro Leu Leu Ile Gly Ile Ala

265 270 275att gtg gca gcg acc aac acc gcc ggt tac gcg cta acc agt tac atg 979Ile Val Ala Ala Thr Asn Thr Ala Gly Tyr Ala Leu Thr Ser Tyr Met

280 285 290cct gtg tat cta gag gag cag atc ggt ctg cac tcc gca tcc gct gcc 1027Pro Val Tyr Leu Glu Glu Gln Ile Gly Leu His Ser Ala Ser Ala Ala

295 300 305gct gtg acc gtg ccg att ctg gtt gtt atg tcc ctg ctg ctg cca ttt 1075Ala Val Thr Val Pro Ile Leu Val Val Met Ser Leu Leu Leu Pro Phe310 315 320 325gtt ggt atg tgg agt gac cgc gtg ggc cgc aag cct gtc tac gcg act 1123Val Gly Met Trp Ser Asp Arg Val Gly Arg Lys Pro Val Tyr Ala Thr

330 335 340gct gtt gcg gca acg ctg atc ttg atg gtt cct gcc ttc ttg atc atg 1171Ala Val Ala Ala Thr Leu Ile Leu Met Val Pro Ala Phe Leu Ile Met

345 350 355aac acc gga acc atc ggc gcc gta ctg att gca ctg tcc atg gtt gct 1219Asn Thr Gly Thr Ile Gly Ala Val Leu Ile Ala Leu Ser Met Val Ala

360 365 370att cca acc ggt ttg tat gtg gca ctg tcc gca tct gcc ctg cca gcg 1267Ile Pro Thr Gly Leu Tyr Val Ala Leu Ser Ala Ser Ala Leu Pro Ala

375 380 385ctg ttc cca acc gcg tca cga ttc tct gga atg ggt att tcc tac aac 1315Leu Phe Pro Thr Ala Ser Arg Phe Ser Gly Met Gly Ile Ser Tyr Asn390 395 400 405att tcc gtg tcg ttg ttc ggt ggt aca acc ccg ctg atc acc cag ttc 1363Ile Ser Val Ser Leu Phe Gly Gly ThrThr Pro Leu Ile Thr Gln Phe

410 415 420ctg ctg cag aag act ggc ctg gat atc gtt cca gcg ctc tac atc atg 1411Leu Leu Gln Lys Thr Gly Leu Asp Ile Val Pro Ala Leu Tyr Ile Met

425 430 435ttc ttc tct gca atc gca ggt gtg gcg ctg ctg ttc atg acc gag tct 1459Phe Phe Ser Ala Ile Ala Gly Val Ala Leu Leu Phe Met Thr Glu Ser

440 445 450tca cag aag cca ctg ctt ggc tca ttc cca acc gtg gaa acc aag tct 1507Ser Gln Lys Pro Leu Leu Gly Ser Phe Pro Thr Val Glu Thr Lys Ser

455 460 465gag gcc gtg gag atc gtg aag aac cag gac gag gat cca aat att gat 1555Glu Ala Val Glu Ile Val Lys Asn Gln Asp Glu Asp Pro Asn Ile Asp470 475 480 485ctt tcc cat atg ccg ttt cct gat gag gaa aac gta ggt gct gaa aag 1603Leu Ser His Met Pro Phe Pro Asp Glu Glu Asn Val Gly Ala Glu Lys

490495500 caa aac gca taaccgtaaa gcccgctgca agg 1635Gln Asn Ala<210>500<211>504<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>500Val Ser Pro Ile Arg Ser Lys Lys Lys Ile Lys Asn Glu Pro Arg Leu 151015 Thr Val Asp Asp Val Asn Val Val Pro Pro Lys Lys Ile Arg Pro Ala

20 25 30Ile Lys Gly Thr Val Val Gly Asn Phe Met Glu Trp Tyr Asp Phe Gly

35 40 45Ile Tyr Gly Tyr Leu Thr Val Thr Met Thr Ala Val Phe Thr Gln Gly

50 55 60Leu Pro Gln Glu Trp Gln Leu Leu Ala Val Met Phe Gly Phe Ala Val 65 70 75 80Ser Tyr Leu Val Arg Pro Leu Gly Gly Leu Val Leu Gly Pro Leu Gly

85 90 95Asp Lys Val Gly Arg Gln Lys Val Leu Tyr Val Thr Met Ala Met Met

100 105 110Ala Val Ser Thr Ala Leu Ile Gly Leu Leu Pro Thr Ala Ala Ser Ile

115 120 125Gly Ala Trp Ala Leu Val Leu Leu Tyr Leu Leu Lys Met Val Gln Gly

130 135 140Phe Ser Thr Gly Gly Glu Tyr Ala Gly Ala Thr Thr Tyr Val Ala Glu145 150 155 160Phe Ala Pro Asp Arg Arg Arg Gly Phe Phe Gly Ala Phe Leu Asp Met

165 170 175Gly Ser Tyr Leu Gly Phe Ala Ala Gly Ala Ser Val Val Ala Ile Thr

180 185 190Thr Trp Val Thr Thr His Phe Tyr Gly Ala Thr Ala Met Glu Asp Phe

195 200 205Gly Trp Arg Ile Pro Phe Leu Thr Ala Ile Pro Leu Gly Ile Ile Ala

210 215 220Val Tyr Leu Arg Thr Arg Ile Pro Glu Thr Pro Ala Phe Glu Asn Asn225 230 235 240Gln Asp Glu Pro Asn Ala Val Val Glu Lys Asp Thr Glu Asp Pro Tyr

245 250 255Ala Arg Leu Gly Leu Ala Gly Val Ile Arg His His Trp Arg Pro Leu

260 265 270Leu Ile Gly Ile Ala Ile Val Ala Ala Thr Asn Thr Ala Gly Tyr Ala

275 280 285Leu Thr Ser Tyr Met Pro Val Tyr Leu Glu Glu Gln Ile Gly Leu His

290 295 300Ser Ala Ser Ala Ala Ala Val Thr Val Pro Ile Leu Val Val Met Ser305 310 315 320Leu Leu Leu Pro Phe Val Gly Met Trp Ser Asp Arg Val Gly Arg Lys

325 330 335Pro Val Tyr Ala Thr Ala Val Ala Ala Thr Leu Ile Leu Met Val Pro

340 345 350Ala Phe Leu Ile Met Asn Thr Gly Thr Ile Gly Ala Val Leu Ile Ala

355 360 365Leu Ser Met Val Ala Ile Pro Thr Gly Leu Tyr Val Ala Leu Ser Ala

370 375 380Ser Ala Leu Pro Ala Leu Phe Pro Thr Ala Ser Arg Phe Ser Gly Met385 390 395 400Gly Ile Ser Tyr Asn Ile Ser Val Ser Leu Phe Gly Gly Thr Thr Pro

405 410 415Leu Ile Thr Gln Phe Leu Leu Gln Lys Thr Gly Leu Asp Ile Val Pro

420 425 430Ala Leu Tyr Ile Met Phe Phe Ser Ala Ile Ala Gly Val Ala Leu Leu

435 440 445Phe Met Thr Glu Ser Ser Gln Lys Pro Leu Leu Gly Ser Phe Pro Thr

450 455 460Val Glu Thr Lys Ser Glu Ala Val Glu Ile Val Lys Asn Gln Asp Glu465 470 475 480Asp Pro Asn Ile Asp Leu Ser His Met Pro Phe Pro Asp Glu Glu Asn

485 490 495Val Gly Ala Glu Lys Gln Asn Ala

500<210>501<211>1509<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1486)<223>RXA02030<400>501gcgcctaaca tctcattgta tgggattgac tctaataatc tcctgtggaa acatcgcaag 60ggtaattatt ggaatctattattgtgtgag gcgataactc gtg acc aca act gat 115

Val Thr Thr Thr Asp

1 5cac tcc acg gag ttg aat cct tct gat cca ggt ggg cag acg gca acc 163His Ser Thr Glu Leu Asn Pro Ser Asp Pro Gly Gly Gln Thr Ala Thr

10 15 20cta gtg att gac aag aaa act aaa cgt cgg gtt gca gca gcc tcc acc 211Leu Val Ile Asp Lys Lys Thr Lys Arg Arg Val Ala Ala Ala Ser Thr

25 30 35atc ggc aca acc atc gag ttc tac gat ttt tat gcg tac gct gcg gca 259Ile Gly Thr Thr Ile Glu Phe Tyr Asp Phe Tyr Ala Tyr Ala Ala Ala

40 45 50gct gtc gtt gtt ttc cca agt ctg ttt ttc cct gcc aat gac aac cca 307Ala Val Val Val Phe Pro Ser Leu Phe Phe Pro Ala Asn Asp Asn Pro

55 60 65acc gtg aac ctg ttg gca tcg ttt gcc acc ttt ggt ctt gcg ttc gtt 355Thr Val Asn Leu Leu Ala Ser Phe Ala Thr Phe Gly Leu Ala Phe Val 70 75 80 85gct cgt cca ctc ggt tca atc att ttc ggg cac ttc ggt gac cgt gtg 403Ala Arg Pro Leu Gly Ser Ile Ile Phe Gly His Phe Gly Asp Arg Val

90 95 100gga cgc aaa gct acc ttg atc ggt tca ctg ctg acc atg ggc att gcc 451Gly Arg Lys Ala Thr Leu Ile Gly Ser Leu Leu Thr Met Gly Ile Ala

105 110 115acc atc ttg atc ggc ctg ctg cct act tat ggt cag gtc gga atc att 499Thr Ile Leu Ile Gly Leu Leu Pro Thr Tyr Gly Gln Val Gly Ile Ile

120 125 130gca ccg gcg ctg ttg gcg ctc atg cgt ttc tgc cag ggc ctg ggcctt 547Ala Pro Ala Leu Leu Ala Leu Met Arg Phe Cys Gln Gly Leu Gly Leu

135 140 145ggc ggt gaa tgg tct ggc gct gcg ttg ctg gct ggt gaa aac gcg gaa 595Gly Gly Glu Trp Ser Gly Ala Ala Leu Leu Ala Gly Glu Asn Ala Glu150 155 160 165aac act cac cgc gct cgt gct gca atg tgg cca cag ctg ggt gca ccg 643Asn Thr His Arg Ala Arg Ala Ala Met Trp Pro Gln Leu Gly Ala Pro

170 175 180ttt ggt ttc ttc ttg gcc aat ggt ttc atg ctc att ctg gtc ggt gtg 691Phe Gly Phe Phe Leu Ala Asn Gly Phe Met Leu Ile Leu Val Gly Val

185 190 195ctt gcc cat cag gac ggc gat ctt cac ggc gcg ttc atg acc tgg ggt 739Leu Ala His Gln Asp Gly Asp Leu His Gly Ala Phe Met Thr Trp Gly

200 205 210tgg cgt ctg cca ttc ctg tct tcg gcg atc atg atc gca gtt ggc ctg 787Trp Arg Leu Pro Phe Leu Ser Ser Ala Ile Met Ile Ala Val Gly Leu

215 220 225tgg gtg cgt ttc tca ctg gag gaa act cca gtg ttc aag cag gct gtt 835Trp Val Arg Phe Ser Leu Glu Glu Thr Pro Val Phe Lys Gln Ala Val230 235 240 245gat cag ggc aag aag gtg aag tct ccg ctc aag gag ctg ttc aag act 883Asp Gln Gly Lys Lys Val Lys Ser Pro Leu Lys Glu Leu Phe Lys Thr

250 255 260tcc cct ggc cct gtt gtg cag gct act ttg atc atg ctg tcc act tat 931Ser Pro Gly Pro Val Val Gln Ala Thr Leu Ile Met Leu Ser Thr Tyr

265 270 275acc ttg ttc tac ctg gtt acc acg tgg att ctg tcg tat ggc atc ggt 979Thr Leu Phe Tyr Leu Val Thr Thr Trp Ile Leu Ser Tyr Gly Ile Gly

280 285 290aat cgc agc acc gga aac ggc ctg tct att ccg tac ttt gag ttc ttg 1027Asn Arg Ser Thr Gly Asn Gly Leu Ser Ile Pro Tyr Phe Glu Phe Leu

295 300 305cag ttg cag ctg gcc acc atc gtg ttc ttc gcc atc atg atc cct gtg 1075Gln Leu Gln Leu Ala Thr Ile Val Phe Phe Ala Ile Met Ile Pro Val310 315 320 325tca ggc tgg ttg gct gat gtg tgg ggt cgt aaa aac acc ctg acc ttg 1123Ser Gly Trp Leu Ala Asp Val Trp Gly Arg Lys Asn Thr Leu Thr Leu

330 335 340gct tct gtg ctg ctt ctc ggc ttt ggt ctg acg ttt aat ctg ctt ctc 1171Ala Ser Val Leu Leu Leu Gly Phe Gly Leu Thr Phe Asn Leu Leu Leu

345 350 355gat cca gag acc gcc acc aag acc acc gtg ttc atc ttc ttg ttc gtg 1219Asp Pro Glu Thr Ala Thr Lys Thr Thr Val Phe Ile Phe Leu Phe Val

360 365 370ggc atg agc atc atg ggt ctg atc ttt gga ccc atg tcg gca att ttg 1267Gly Met Ser Ile Met Gly Leu Ile Phe Gly Pro Met Ser Ala Ile Leu

375 380 385ccg gag ctc ttc ccc acc aac gtc cgc tac acg ggc tcc gga atc gcc 1315Pro Glu Leu Phe Pro Thr Asn Val Arg Tyr Thr Gly Ser Gly Ile Ala390 395 400 405tac aat gtc tcc tcg atc ctc ggt gca gct att gca ccg ttc atc gca 1363Tyr Asn Val Ser Ser Ile Leu Gly Ala Ala Ile Ala Pro Phe Ile Ala

410 415 420acg tgg ctg gtg tcc gag ttt tca gtg gcg tac gtc ggc tat tac ctc 1411Thr Trp Leu Val Ser Glu Phe Ser Val Ala Tyr Val Gly Tyr Tyr Leu

425 430 435atc atc gtc acc gca att acc ttt gtt gcg gtg ctg acg atg aag gaa 1459Ile Ile Val Thr Ala Ile Thr Phe Val Ala Val Leu Thr Met Lys Glu

440 445 450aac aaa aac cac gac ctc cga gag gtc taaaagattt ttgcttatcg 1506Asn Lys Asn His Asp Leu Arg Glu Val

455460 acg1509<210>502<211>462<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>502Val Thr Thr Thr Asp His Ser Thr Glu Leu Asn Pro Ser Asp Pro Gly 151015 Gly Gln Thr Ala Thr Leu Val Ile Asp Lys Lys Thr Lys Arg Arg Val

20 25 30Ala Ala Ala Ser Thr Ile Gly Thr Thr Ile Glu Phe Tyr Asp Phe Tyr

35 40 45Ala Tyr Ala Ala Ala Ala Val Val Val Phe Pro Ser Leu Phe Phe Pro

50 55 60Ala Asn Asp Asn Pro Thr Val Asn Leu Leu Ala Ser Phe Ala Thr Phe 65 70 75 80Gly Leu Ala Phe Val Ala Arg Pro Leu Gly Ser Ile Ile Phe Gly His

85 90 95Phe Gly Asp Arg Val Gly Arg Lys Ala Thr Leu Ile Gly Ser Leu Leu

100 105 110Thr Met Gly Ile Ala Thr Ile Leu Ile Gly Leu Leu Pro Thr Tyr Gly

115 120 125Gln Val Gly Ile Ile Ala Pro Ala Leu Leu Ala Leu Met Arg Phe Cys

130 135 140Gln Gly Leu Gly Leu Gly Gly Glu Trp Ser Gly Ala Ala Leu Leu Ala145 150 155 160Gly Glu Asn Ala Glu Asn Thr His Arg Ala Arg Ala Ala Met Trp Pro

165 170 175Gln Leu Gly Ala Pro Phe Gly Phe Phe Leu Ala Asn Gly Phe Met Leu

180 185 190Ile Leu Val Gly Val Leu Ala His Gln Asp Gly Asp Leu His Gly Ala

195 200 205Phe Met Thr Trp Gly Trp Arg Leu Pro Phe Leu Ser Ser Ala Ile Met

210 215 220Ile Ala Val Gly Leu Trp Val Arg Phe Ser Leu Glu Glu Thr Pro Val225 230 235 240Phe Lys Gln Ala Val Asp Gln Gly Lys Lys Val Lys Ser Pro Leu Lys

245 250 255Glu Leu Phe Lys Thr Ser Pro Gly Pro Val Val Gln Ala Thr Leu Ile

260 265 270Met Leu Ser Thr Tyr Thr Leu Phe Tyr Leu Val Thr Thr Trp Ile Leu

275 280 285Ser Tyr Gly Ile Gly Asn Arg Ser Thr Gly Asn Gly Leu Ser Ile Pro

290 295 300Tyr Phe Glu Phe Leu Gln Leu Gln Leu Ala Thr Ile Val Phe Phe Ala305 310 315 320Ile Met Ile Pro Val Ser Gly Trp Leu Ala Asp Val Trp Gly Arg Lys

325 330 335Asn Thr Leu Thr Leu Ala Ser Val Leu Leu Leu Gly Phe Gly Leu Thr

340 345 350Phe Asn Leu Leu Leu Asp Pro Glu Thr Ala Thr Lys Thr Thr Val Phe

355 360 365Ile Phe Leu Phe Val Gly Met Ser Ile Met Gly Leu Ile Phe Gly Pro

370 375 380Met Ser Ala Ile Leu Pro Glu Leu Phe Pro Thr Asn Val Arg Tyr Thr385 390 395 400Gly Ser Gly Ile Ala Tyr Asn Val Ser Ser Ile Leu Gly Ala Ala Ile

405 410 415Ala Pro Phe Ile Ala Thr Trp Leu Val Ser Glu Phe Ser Val Ala Tyr

420 425 430Val Gly Tyr Tyr Leu Ile Ile Val Thr Ala Ile Thr Phe Val Ala Val

435 440 445Leu Thr Met Lys Glu Asn Lys Asn Hi s Asp Leu Arg Glu Val

450455460<210>503<211>870<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (847)<223>RXA00186<400>503agaagcccag cattttgttt agctcacctc taaagctcct gatctggata cgaggactcc 60tgcggaaaac cgtgtggcta gtgaagctac ccggcatctc atg ggg gag aag act 115

Met Gly Glu Lys Thr

1 5tct gtc gcg tat gtt cac gat gtt ctg atc aag ggc gtg cca gtg cgg 163Ser Val Ala Tyr Val His Asp Val Leu Ile Lys Gly Val Pro Val Arg

10 15 20ata tac aat ccg cac ccc aac gac ggg ccg ctt cct gtc ttt atc tac 211Ile Tyr Asn Pro His Pro Asn Asp Gly Pro Leu Pro Val Phe Ile Tyr

25 30 35ttc cat ggt ggc gga tgg gtt ttg ggg gac ctt gaa tca gtg gat tcc 259Phe His Gly Gly Gly Trp Val Leu Gly Asp Leu Glu Ser Val Asp Ser

40 45 50acc gtg cgc gat att gcc gtt gct tca ggc gcc ctg tgt atc agt gtg 307Thr Val Arg Asp Ile Ala Val Ala Ser Gly Ala Leu Cys Ile Ser Val

55 60 65gat tat cgc cgt gca ccg gaa cat cct ttt ctc gct gca ttg gat gat 355Asp Tyr Arg Arg Ala Pro Glu His Pro Phe Leu Ala Ala Leu Asp Asp 7075 80 85tgc caa gtg gtc acg gaa gct gtc ctc aat ggt gaa ctc gcc agt gct 403Cys Gln Val Val Thr Glu Ala Val Leu Asn Gly Glu Leu Ala Ser Ala

90 95 100aac cag cat cta gtg gca gtc ggc ggg gac agc gcc ggt ggc aat att 451Asn Gln His Leu Val Ala Val Gly Gly Asp Ser Ala Gly Gly Asn Ile

105 110 115gcg gcg gtc atc gct caa cag ctg cgc gat cag atc acc cac caa gtt 499Ala Ala Val Ile Ala Gln Gln Leu Arg Asp Gln Ile Thr His Gln Val

120 125 130ctt gtg tat ccg gtg atg gac gta atc ttg ctg gtg att tgt tct atc 547Leu Val Tyr Pro Val Met Asp Val Ile Leu Leu Val Ile Cys Ser Ile

135 140 145att acc act ggt ttt gcg ctg ctc atg cat cca aag agc aag gac aag 595Ile Thr Thr Gly Phe Ala Leu Leu Met His Pro Lys Ser Lys Asp Lys150 155 160 165acg gag acg att tct gat gaa ttc ctc gca gag atc caa gcg gga agt 643Thr Glu Thr Ile Ser Asp Glu Phe Leu Ala Glu Ile Gln Ala Gly Ser

170 175 180gaa aag atc tcc att ctg cgt tcg acc cct gct gaa aaa gcc aat gcg 691Glu Lys Ile Ser Ile Leu Arg Ser Thr Pro Ala Glu Lys Ala Asn Ala

185 190 195agc cgt tgg atc atg tac ttc gtt ggc gga att ggc ctg ctc tac agc 739Ser Arg Trp Ile Met Tyr Phe Val Gly Gly Ile Gly Leu Leu Tyr Ser

200 205 210gtg ttc agc ctg tgg aca ggt ggc gta acc gga ctg acg ttg aac tcc 787Val Phe Ser Leu Trp Thr Gly Gly Val Thr Gly Leu Thr Leu Asn Ser

215220225 ttc aac ttc ctg ttc ctg tca ctc ggc atg gtg ctc acc gct aat tac 835Phe Asn Phe Leu Phe Leu Ser Leu Gly Met Val Leu Thr Ala Asn Tyr 230235240245 ggg cca gag tat taagcaaagc ttattcgcga agg 870Gly Pro Glu Tyr<210>504<211>249<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>504Met Gly Glu Lys Thr Ser Val Ala Tyr Val His Asp Val Leu Ile Lys 151015 Gly Val Pro Val Arg Ile Tyr Asn Pro His Pro Asn Asp Gly Pro Leu

20 25 30Pro Val Phe Ile Tyr Phe His Gly Gly Gly Trp Val Leu Gly Asp Leu

35 40 45Glu Ser Val Asp Ser Thr Val Arg Asp Ile Ala Val Ala Ser Gly Ala

50 55 60Leu Cys Ile Ser Val Asp Tyr Arg Arg Ala Pro Glu His Pro Phe Leu 65 70 75 80Ala Ala Leu Asp Asp Cys Gln Val Val Thr Glu Ala Val Leu Asn Gly

85 90 95Glu Leu Ala Ser Ala Asn Gln His Leu Val Ala Val Gly Gly Asp Ser

100 105 110Ala Gly Gly Asn Ile Ala Ala Val Ile Ala Gln Gln Leu Arg Asp Gln

115 120 125Ile Thr His Gln Val Leu Val Tyr Pro Val Met Asp Val Ile Leu Leu

130 135 140Val Ile Cys Ser Ile Ile Thr Thr Gly Phe Ala Leu Leu Met His Pro145 150 155 160Lys Ser Lys Asp Lys Thr Glu Thr Ile Ser Asp Glu Phe Leu Ala Glu

165 170 175Ile Gln Ala Gly Ser Glu Lys Ile Ser Ile Leu Arg Ser Thr Pro Ala

180 185 190Glu Lys Ala Asn Ala Ser Arg Trp Ile Met Tyr Phe Val Gly Gly Ile

195 200 205Gly Leu Leu Tyr Ser Val Phe Ser Leu Trp Thr Gly Gly Val Thr Gly

210 215 220Leu Thr Leu Asn Ser Phe Asn Phe Leu Phe Leu Ser Leu Gly Met Val225 230 235 240Leu Thr Ala Asn Tyr Gly Pro Glu Tyr

245<210>505<211>468<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (451)<223>RXA00187<400>505gcttattcgc gaaggcatcc aaggaacgtg gggattcatt cttcaattcc cgttctacgc 60aggcattttc gggttgattt ccttcaccgg tctgggtgtt gtg atc tcc gga ttt 115

Val Ile Ser Gly Phe

1 5ttc acc tcg att tcc acg gca acc acg tgg cct gtc atc gcg ttc ctc 163Phe Thr Ser Ile Ser Thr Ala Thr Thr Trp Pro Val Ile Ala Phe Leu

10 15 20tac tct gga ctg ctc aac atc gcg gtg cct tca ggt ggc tcg aaa ttc 211Tyr Ser Gly Leu Leu Asn Ile Ala Val Pro Ser Gly Gly Ser Lys Phe

25 30 35atc atc gaa gcc ccg tac atc atc cca acc cca gtg gat ctt ggc gct 259Ile Ile Glu Ala Pro Tyr Ile Ile Pro Thr Pro Val Asp Leu Gly Ala

40 45 50gac atg ggc ctt gtc ctg cag gct tat caa atg agt gat ggc gcg acc 307Asp Met Gly Leu Val Leu Gln Ala Tyr Gln Met Ser Asp Gly Ala Thr

55 60 65aac ctg ctc att ccg ttc ttc gcg ctg cca tat ttg gcc aat ttc aag 355Asn Leu Leu Ile Pro Phe Phe Ala Leu Pro Tyr Leu Ala Asn Phe Lys 70 75 80 85atc aaa ttc agc caa gtg gtg ggc tat aca gttccg cct gtc ctc gtt 403Ile Lys Phe Ser Gln Val Val Gly Tyr Thr Val Pro Pro Val Leu Val

90 95 100gtt atc gcc gtg atc tgc att tac ctg ttc ctg cga gca tca atc att 451Val Ile Ala Val Ile Cys Ile Tyr Leu Phe Leu Arg Ala Ser Ile Ile

105110115 taaaaagatg cttctcg 468<210>506<211>117<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>506Val Ile Ser Gly Phe Phe Thr Ser Ile Ser Thr Ala Thr Thr Trp Pro 151015 Val Ile Ala Phe Leu Tyr Ser Gly Leu Leu Asn Ile Ala Val Pro Ser

20 25 30Gly Gly Ser Lys Phe Ile Ile Glu Ala Pro Tyr Ile Ile Pro Thr Pro

35 40 45Val Asp Leu Gly Ala Asp Met Gly Leu Val Leu Gln Ala Tyr Gln Met

50 55 60Ser Asp Gly Ala Thr Asn Leu Leu Ile Pro Phe Phe Ala Leu Pro Tyr 65 70 75 80Leu Ala Asn Phe Lys Ile Lys Phe Ser Gln Val Val Gly Tyr Thr Val

85 90 95Pro Pro Val Leu Val Val Ile Ala Val Ile Cys Ile Tyr Leu Phe Leu

100 105 110Arg Ala Ser Ile Ile

115<210>507<211>1329<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1306)<223>RXA01667<400>507tctcggcgtt gatgatcatc cgcaatatca tgccgccgca agattccgct tttccagact 60ttgctcattc cttcctctat tactgctcgc catcatcggc atg att ttg ggg cct 115

Met Ile Leu Gly Pro

15aag gtg ttg ggt ctg att ggt tgg tcg gat cat ctt tcc act tac act 163Lys Val Leu Gly Leu Ile Gly Trp Ser Asp His Leu Ser Thr Tyr Thr

10 15 20acg gtg ctc att gcg att gtg ttt gct tcg atg ccg tat tcg atg aag 211Thr Val Leu Ile Ala Ile Val Phe Ala Ser Met Pro Tyr Ser Met Lys

25 30 35ttt gac cgt ggc gtg cgt act ggc atg aag acg atg tgg gcg tat tcg 259Phe Asp Arg Gly Val Arg Thr Gly Met Lys Thr Met Trp Ala Tyr Ser

40 45 50act gcg atg ttt gtg ggg cag tgg ggt ctg ttc att ttg ctg ggt ctg 307Thr Ala Met Phe Val Gly Gln Trp Gly Leu Phe Ile Leu Leu Gly Leu

55 60 65ttt ttg ttc caa ccg gtg tgg ggt acc gat gag tgg ttc ggc atg atg 355Phe Leu Phe Gln Pro Val Trp Gly Thr Asp Glu Trp Phe Gly Met Met 70 75 80 85ttg ccg gtt ggt ttt gtt ggt ggt ttt ggt act gct gct gcg gtg ggt 403Leu Pro Val Gly Phe Val Gly Gly Phe Gly Thr Ala Ala Ala Val Gly

90 95 100act gcg ttg gag tct tcg ggt gcg gag gct gcg atg tct ttg ggc ttt 451Thr Ala Leu Glu Ser Ser Gly Ala Glu Ala Ala Met Ser Leu Gly Phe

105 110 115acc tct gcg acg gtg ggt act ttt gct gcg att gtt ggt gga att att 499Thr Ser Ala Thr Val Gly Thr Phe Ala Ala Ile Val Gly Gly Ile Ile

120 125 130ttc aca acg tgg ggt att aag aag ggc aag act gcg gcg atg cct gcg 547Phe Thr Thr Trp Gly Ile Lys Lys Gly Lys Thr Ala Ala Met Pro Ala

135 140 145cag ttg ccg tgg gat ttg cgt tcg ggt tat atc gat aag ctg agt gat 595Gln Leu Pro Trp Asp Leu Arg Ser Gly Tyr Ile Asp Lys Leu Ser Asp150 155 160 165cgt ccg tcg att ggt aag gcg agt acg aat ccg tct gcg att gag cct 643Arg Pro Ser Ile Gly Lys Ala Ser Thr Asn Pro Ser Ala Ile Glu Pro

170 175 180ttg gcg ctg cat act ggc att att ttg ttg act gtt gcg gtt gcg tat 691Leu Ala Leu His Thr Gly Ile Ile Leu Leu Thr Val Ala Val Ala Tyr

185 190 195tcc att aat cag tgg ttg ggt agc atg ttc cca acc gtg cag att ccg 739Ser Ile Asn Gln Trp Leu Gly Ser Met Phe Pro Thr Val Gln Ile Pro

200 205 210ttg ttt gcg atg tca ttt gtg gtc ggc att gtg ggc atg gga att atg 787Leu Phe Ala Met Ser Phe Val Val Gly Ile Val Gly Met Gly Ile Met

215 220 225cgt ttg ttg aag aag cct gag tat ttg gat cgc gac acc gtg aat tcc 835Arg Leu Leu Lys Lys Pro Glu Tyr Leu Asp Arg Asp Thr Val Asn Ser230 235 240 245gtg tcg ggc gcg gcg acg gat tac ctc att gcg ttt ggt att gcc tcg 883Val Ser Gly Ala Ala Thr Asp Tyr Leu Ile Ala Phe Gly Ile Ala Ser

250 255 260att gct cct gct gcg att gct gat tac tgg gtt cct ctt gtg gtg ctg 931Ile Ala Pro Ala Ala Ile Ala Asp Tyr Trp Val Pro Leu Val Val Leu

265 270 275ttt gtt ttg ggc acc atc aac tgt tgt ttc ttc ttt ttc tgg gtt gcg 979Phe Val Leu Gly Thr Ile Asn Cys Cys Phe Phe Phe Phe Trp Val Ala

280 285 290cct cgt ttc ttt ggc gag aag tgg ctg gag cgc gcg atc ttc ggt tgg 1027Pro Arg Phe Phe Gly Glu Lys Trp Leu Glu Arg Ala Ile Phe Gly Trp

295 300 305ggt tgg gct act gcc gcg gtt gct acc ggt atc gcg ttg ctg aag atc 1075Gly Trp Ala Thr Ala Ala Val Ala Thr Gly Ile Ala Leu Leu Lys Ile310 315 320 325gtg gat ccg aag ttg aag tcg gga gcg ctt aat gag tac ggc gtg gct 1123Val Asp Pro Lys Leu Lys Ser Gly Ala Leu Asn Glu Tyr Gly Val Ala

330 335 340tat atc ggt ttt gct cca ttt gaa atc ggc atg acc atc atc gcg ccg 1171Tyr Ile Gly Phe Ala Pro Phe Glu Ile Gly Met Thr Ile Ile Ala Pro

345 350 355atc gcg gtg ctc gca ggc ttt acc atg ggg ttg ggt tgg gcg tcg ttg 1219Ile Ala Val Leu Ala Gly Phe Thr Met Gly Leu Gly Trp Ala Ser Leu

360 365 370att gtt gcg atc gtg att ttt ggc ctc gcg tgg ggt ctg aag tgg ttg 1267Ile Val Ala Ile Val Ile Phe Gly Leu Ala Trp Gly Leu Lys Trp Leu

375380385 ccg gag cgc gga cat gtc cgc ggc gag ggt aag ccg caa taaaggttgg 1316Pro Glu Arg Gly His Val Arg Gly Glu Gly Lys Pro Gln 390395400 aagcgccgggg tct 1329<210>508<211>402<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>508Met Ile Leu Gly Pro Lys Val Leu Gly Leu Ile Gly Trp Ser Asp His 151015 Leu Ser Thr Tyr Thr Thr Val Leu Ile Ala Ile Val Phe Ala Ser Met

20 25 30Pro Tyr Ser Met Lys Phe Asp Arg Gly Val Arg Thr Gly Met Lys Thr

35 40 45Met Trp Ala Tyr Ser Thr Ala Met Phe Val Gly Gln Trp Gly Leu Phe

50 55 60Ile Leu Leu Gly Leu Phe Leu Phe Gln Pro Val Trp Gly Thr Asp Glu 65 70 75 80Trp Phe Gly Met Met Leu ProVal Gly Phe Val Gly Gly Phe Gly Thr

85 90 95Ala Ala Ala Val Gly Thr Ala Leu Glu Ser Ser Gly Ala Glu Ala Ala

100 105 110Met Ser Leu Gly Phe Thr Ser Ala Thr Val Gly Thr Phe Ala Ala Ile

115 120 125Val Gly Gly Ile Ile Phe Thr Thr Trp Gly Ile Lys Lys Gly Lys Thr

130 135 140Ala Ala Met Pro Ala Gln Leu Pro Trp Asp Leu Arg Ser Gly Tyr Ile145 150 155 160Asp Lys Leu Ser Asp Arg Pro Ser Ile Gly Lys Ala Ser Thr Asn Pro

165 170 175Ser Ala Ile Glu Pro Leu Ala Leu His Thr Gly Ile Ile Leu Leu Thr

180 185 190Val Ala Val Ala Tyr Ser Ile Asn Gln Trp Leu Gly Ser Met Phe Pro

195 200 205Thr Val Gln Ile Pro Leu Phe Ala Met Ser Phe Val Val Gly Ile Val

210 215 220Gly Met Gly Ile Met Arg Leu Leu Lys Lys Pro Glu Tyr Leu Asp Arg225 230 235 240Asp Thr Val Asn Ser Val Ser Gly Ala Ala Thr Asp Tyr Leu Ile Ala

245 250 255Phe Gly Ile Ala Ser Ile Ala Pro Ala Ala Ile Ala Asp Tyr Trp Val

260 265 270Pro Leu Val Val Leu Phe Val Leu Gly Thr Ile Asn Cys Cys Phe Phe

275 280 285Phe Phe Trp Val Ala Pro Arg Phe Phe Gly Glu Lys Trp Leu Glu Arg

290 295 300Ala Ile Phe Gly Trp Gly Trp Ala Thr Ala Ala Val Ala Thr Gly Ile305 310 315 320Ala Leu Leu Lys Ile Val Asp Pro Lys Leu Lys Ser Gly Ala Leu Asn

325 330 335Glu Tyr Gly Val Ala Tyr Ile Gly Phe Ala Pro Phe Glu Ile Gly Met

340 345 350Thr Ile Ile Ala Pro Ile Ala Val Leu Ala Gly Phe Thr Met Gly Leu

355 360 365Gly Trp Ala Ser Leu Ile Val Ala Ile Val Ile Phe Gly Leu Ala Trp

370375380 Gly Leu Lys Trp Leu Pro Glu Arg Gly His Val Arg Gly Glu Gly Lys 385390395400 Pro Gln<210>509<211>1776<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1753)<223>RXA02171<400>509aaccacattc gtcattactt acatctatgt catgtttgcg aacaagaact tggagcctcg 60tcaggctgct attcgccaga agatggaagg ttaatcagat atg aat tcc act att 115

Met Asn Ser Thr Ile

1 5ctc ctt gca caa gac gct gtt tct gag ggc gtc ggt aat ccg att ctt 163Leu Leu Ala Gln Asp Ala Val Ser Glu Gly Val Gly Asn Pro Ile Leu

10 15 20aac atc agt gtc ttc gtc gtc ttc att att gtg acg atg acc gtg gtg 211Asn Ile Ser Val Phe Val Val Phe Ile Ile Val Thr Met Thr Val Val

25 30 35ctt cgc gtg ggc aag agc acc agc gaa tcc acc gac ttc tac acc ggt 259Leu Arg Val Gly Lys Ser Thr Ser Glu Ser Thr Asp Phe Tyr Thr Gly

40 45 50ggt gct tcc ttc tcc gga acc cag aac ggt ctg gct atc gca ggt gac 307Gly AlaSer Phe Ser Gly Thr Gln Asn Gly Leu Ala Ile Ala Gly Asp

55 60 65tac ctg tct gca gcg tcc ttc ctc gga atc gtt ggt gca att tca ctc 355Tyr Leu Ser Ala Ala Ser Phe Leu Gly Ile Val Gly Ala Ile Ser Leu 70 75 80 85aac ggt tac gac gga ttc ctt tac tcc atc ggc ttc ttc gtc gca tgg 403Asn Gly Tyr Asp Gly Phe Leu Tyr Ser Ile Gly Phe Phe Val Ala Trp

90 95 100ctt gtt gca ctg ctg ctc gtg gca gag cca ctt cgt aac gtg ggc cgc 451Leu Val Ala Leu Leu Leu Val Ala Glu Pro Leu Arg Asn Val Gly Arg

105 110 115ttc acc atg gct gac gtg ctg tcc ttc cga ctg cgt cag aaa cca gtc 499Phe Thr Met Ala Asp Val Leu Ser Phe Arg Leu Arg Gln Lys Pro Val

120 125 130cgc gtc gct gcg gcc tgc ggt acc ctc gcg gtt acc ctc ttt tac ttg 547Arg Val Ala Ala Ala Cys Gly Thr Leu Ala Val Thr Leu Phe Tyr Leu

135 140 145atc gct cag atg gct ggt gca ggt tcg ctt gtg tcc gtt ctg ctg gac 595Ile Ala Gln Met Ala Gly Ala Gly Ser Leu Val Ser Val Leu Leu Asp150 155 160 165atc cac gag ttc aag tgg cag gca gtt gtt gtc ggt atc gtt ggc att 643Ile His Glu Phe Lys Trp Gln Ala Val Val Val Gly Ile Val Gly Ile

170 175 180gtc atg atc gcc tac gtt ctt ctt ggc ggt atg aag ggc acc aca tac 691Val Met Ile Ala Tyr Val Leu Leu Gly Gly Met Lys Gly Thr Thr Tyr

185 190 195gtt cag atg att aag gca gtt ctg ctg gtc ggt ggc gtt gcc att atg 739Val Gln Met Ile Lys Ala Val Leu Leu Val Gly Gly Val Ala Ile Met

200 205 210acc gtt ctg acc ttc gtc aag gtg tct ggt ggc ctg acc acc ctt tta 787Thr Val Leu Thr Phe Val Lys Val Ser Gly Gly Leu Thr Thr Leu Leu

215 220 225aat gac gct gtt gag aag cac gcc gct tca gat tac gct gcc acc aag 835Asn Asp Ala Val Glu Lys His Ala Ala Ser Asp Tyr Ala Ala Thr Lys230 235 240 245ggg tac gat cca acc cag atc ctg gag cct ggt ctg cag tac ggt gca 883Gly Tyr Asp Pro Thr Gln Ile Leu Glu Pro Gly Leu Gln Tyr Gly Ala

250 255 260act ctg acc act cag ctg gac ttc att tcc ttg gct ctc gct ctg tgt 931Thr Leu Thr Thr Gln Leu Asp Phe Ile Ser Leu Ala Leu Ala Leu Cys

265 270 275ctt gga acc gct ggt ctg cca cac gtt ctg atg cgc ttc tac acc gtt 979Leu Gly Thr Ala Gly Leu Pro His Val Leu Met Arg Phe Tyr Thr Val

280 285 290cct acc gcc aag gaa gca cgt aag tct gtg acc tgg gct atc gtc ctc 1027Pro Thr Ala Lys Glu Ala Arg Lys Ser Val Thr Trp Ala Ile Val Leu

295 300 305att ggt gcg ttc tac ctg atg acc ctg gtc ctt ggt tac ggc gct gcg 1075Ile Gly Ala Phe Tyr Leu Met Thr Leu Val Leu Gly Tyr Gly Ala Ala310 315 320 325gca ctg gtc ggt cca gac cgc gtc att gcc gca cca ggt gct gct aat 1123Ala Leu Val Gly Pro Asp Arg Val Ile Ala Ala Pro Gly Ala Ala Asn

330 335 340gct gct gct cct ctg ctg gcc ttc gag ctt ggt ggt tcc atc ttc atg 1171Ala Ala Ala Pro Leu Leu Ala Phe Glu Leu Gly Gly Ser Ile Phe Met

345 350 355gcg ctg att tcc gca gtt gcg ttc gct acc gtt ctc gccgtg gtc gca 1219Ala Leu Ile Ser Ala Val Ala Phe Ala Thr Val Leu Ala Val Val Ala

360 365 370ggt ctt gca att acc gca tcc gct gct gtt ggt cac gac atc tac aac 1267Gly Leu Ala Ile Thr Ala Ser Ala Ala Val Gly His Asp Ile Tyr Asn

375 380 385gct gtt atc cgc aac ggt cag tcc acc gaa gcg gag cag gtc cga gta 1315Ala Val Ile Arg Asn Gly Gln Ser Thr Glu Ala Glu Gln Val Arg Val390 395 400 405tcc cgc atc acc gtt gtc gtc att ggc ctg att tcc att gtc ctg gga 1363Ser Arg Ile Thr Val Val Val Ile Gly Leu Ile Ser Ile Val Leu Gly

410 415 420att ctt gca atg acc cag aac gtt gcg ttc ctc gtg gcc ctg gcc ttc 1411Ile Leu Ala Met Thr Gln Asn Val Ala Phe Leu Val Ala Leu Ala Phe

425 430 435gca gtt gca gca tcc gct aac ctg cca acc atc ctg tac tcc ctg tac 1459Ala Val Ala Ala Ser Ala Asn Leu Pro Thr Ile Leu Tyr Ser Leu Tyr

440 445 450tgg aag aag ttc aac acc acc ggc gct gtg gcc gct atc tac acc ggt 1507Trp Lys Lys Phe Asn Thr Thr Gly Ala Val Ala Ala Ile Tyr Thr Gly

455 460 465ctc atc tcc gcg ctg ctg ctg atc ttc ctg tcc cca gca gtc tcc ggt 1555Leu Ile Ser Ala Leu Leu Leu Ile Phe Leu Ser Pro Ala Val Ser Gly470 475 480 485aat gac agc gca atg gtt cca ggt gca gac tgg gca atc ttc cca ctg 1603Asn Asp Ser Ala Met Val Pro Gly Ala Asp Trp Ala Ile Phe Pro Leu

490 495 500aag aac cca ggc ctc gtc tcc atc cca ctg gca ttc atc gct ggt tgg 1651Lys Asn Pro Gly Leu Val Ser Ile Pro Leu Ala Phe Ile Ala Gly Trp

505 510 515atc ggc act ttg gtt ggc aag cca gac aac atg gat gat ctt gct gcc 1699Ile Gly Thr Leu Val Gly Lys Pro Asp Asn Met Asp Asp Leu Ala Ala

520 525 530gaa atg gaa gtt cgt tcc ctc acc ggt gtc ggt gtt gaa aag gct gtt 1747Glu Met Glu Val Arg Ser Leu Thr Gly Val Gly Val Glu Lys Ala Val

535540545 gat cac taaatctagt ttctgaagtt att 1776Asp His550<210>510<211>551<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>510Met Asn Ser Thr Ile Leu Leu Ala Gln Asp Ala Val Ser Glu Gly Val 151015 Gly Asn Pro Ile Leu Asn Ile Ser Val Phe Val Val Phe Ile Ile Val

20 25 30Thr Met Thr Val Val Leu Arg Val Gly Lys Ser Thr Ser Glu Ser Thr

35 40 45Asp Phe Tyr Thr Gly Gly Ala Ser Phe Ser Gly Thr Gln Asn Gly Leu

50 55 60Ala Ile Ala Gly Asp Tyr Leu Ser Ala Ala Ser Phe Leu Gly Ile Val 65 70 75 80Gly Ala Ile Ser Leu Asn Gly Tyr Asp Gly Phe Leu Tyr Ser Ile Gly

85 90 95Phe Phe Val Ala Trp Leu Val Ala Leu Leu Leu Val Ala Glu Pro Leu

100 105 110Arg Asn Val Gly Arg Phe Thr Met Ala Asp Val Leu Ser Phe Arg Leu

115 120 125Arg Gln Lys Pro Val Arg Val Ala Ala Ala Cys Gly Thr Leu Ala Val

130 135 140Thr Leu Phe Tyr Leu Ile Ala Gln Met Ala Gly Ala Gly Ser Leu Val145 150 155 160Ser Val Leu Leu Asp Ile His GluPhe Lys Trp Gln Ala Val Val Val

165 170 175Gly Ile Val Gly Ile Val Met Ile Ala Tyr Val Leu Leu Gly Gly Met

180 185 190Lys Gly Thr Thr Tyr Val Gln Met Ile Lys Ala Val Leu Leu Val Gly

195 200 205Gly Val Ala Ile Met Thr Val Leu Thr Phe Val Lys Val Ser Gly Gly

210 215 220Leu Thr Thr Leu Leu Asn Asp Ala Val Glu Lys His Ala Ala Ser Asp225 230 235 240Tyr Ala Ala Thr Lys Gly Tyr Asp Pro Thr Gln Ile Leu Glu Pro Gly

245 250 255Leu Gln Tyr Gly Ala Thr Leu Thr Thr Gln Leu Asp Phe Ile Ser Leu

260 265 270Ala Leu Ala Leu Cys Leu Gly Thr Ala Gly Leu Pro His Val Leu Met

275 280 285Arg Phe Tyr Thr Val Pro Thr Ala Lys Glu Ala Arg Lys Ser Val Thr

290 295 300Trp Ala Ile Val Leu Ile Gly Ala Phe Tyr Leu Met Thr Leu Val Leu305 310 315 320Gly Tyr Gly Ala Ala Ala Leu Val Gly Pro Asp Arg Val Ile Ala Ala

325 330 335Pro Gly Ala Ala Asn Ala Ala Ala Pro Leu Leu Ala Phe Glu Leu Gly

340 345 350Gly Ser Ile Phe Met Ala Leu Ile Ser Ala Val Ala Phe Ala Thr Val

355 360 365Leu Ala Val Val Ala Gly Leu Ala Ile Thr Ala Ser Ala Ala Val Gly

370 375380His Asp Ile Tyr Asn Ala Val Ile Arg Asn Gly Gln Ser Thr Glu Ala385 390 395 400Glu Gln Val Arg Val Ser Arg Ile Thr Val Val Val Ile Gly Leu Ile

405 410 415Ser Ile Val Leu Gly Ile Leu Ala Met Thr Gln Asn Val Ala Phe Leu

420 425 430Val Ala Leu Ala Phe Ala Val Ala Ala Ser Ala Asn Leu Pro Thr Ile

435 440 445Leu Tyr Ser Leu Tyr Trp Lys Lys Phe Asn Thr Thr Gly Ala Val Ala

450 455 460Ala Ile Tyr Thr Gly Leu Ile Ser Ala Leu Leu Leu Ile Phe Leu Ser465 470 475 480Pro Ala Val Ser Gly Asn Asp Ser Ala Met Val Pro Gly Ala Asp Trp

485 490 495Ala Ile Phe Pro Leu Lys Asn Pro Gly Leu Val Ser Ile Pro Leu Ala

500 505 510Phe Ile Ala Gly Trp Ile Gly Thr Leu Val Gly Lys Pro Asp Asn Met

515 520 525Asp Asp Leu Ala Ala Glu Met Glu Val Arg Ser Leu Thr Gly Val Gly

530535540 Val Glu Lys Ala Val Asp His 545550<210>511<211>1333<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101) }, (1333)<223>RXA00902<400>511ttgttattgg tttgttcact cccatgcaat gtacgatcgg ttctaacgtc tacggcaatt 60gacacgtcaa tttaattcag gaaaggggtg gggagaattt atg tct agt ggt ttt 115

Met Ser Ser Gly Phe

1 5gaa tat gtt caa cat cct cga cga gcc ctc cctccg cct ata cct gaa 163Glu Tyr Val Gln His Pro Arg Arg Ala Leu Pro Pro Pro Ile Pro Glu

10 15 20cgg aaa ggt cct gcc gca gca ttc ctg ccg gga act ttc cat ccc att 211Arg Lys Gly Pro Ala Ala Ala Phe Leu Pro Gly Thr Phe His Pro Ile

25 30 35aat cca aag aat att gca gcg agc cac gat cag gtg ctt cta tct ggt 259Asn Pro Lys Asn Ile Ala Ala Ser His Asp Gln Val Leu Leu Ser Gly

40 45 50tgg ggc aaa ttt gtg cgt tgg ctc ttg gta ttg ttg tcc att ttg gtc 307Trp Gly Lys Phe Val Arg Trp Leu Leu Val Leu Leu Ser Ile Leu Val

55 60 65atc atc att ggc atc aac ctc atc ttg gac ggt gtc tac gga ttt ggt 355Ile Ile Ile Gly Ile Asn Leu Ile Leu Asp Gly Val Tyr Gly Phe Gly 70 75 80 85act ttt tca acc acc cag atg tac caa gtt gcg aaa gat cca ctc att 403Thr Phe Ser Thr Thr Gln Met Tyr Gln Val Ala Lys Asp Pro Leu Ile

90 95 100ggt gtg ctg atc ggt atc ttg gct acg gcc ttg gtg caa tca tca acc 451Gly Val Leu Ile Gly Ile Leu Ala Thr Ala Leu Val Gln Ser Ser Thr

105 110 115acc acc aca acg ttg acg gtg act gca gtt ggt acg ggc att gtg tcg 499Thr Thr Thr Thr Leu Thr Val Thr Ala Val Gly Thr Gly Ile Val Ser

120 125 130gtg cct gtg gcg att ccg atc att ctt ggc gca aat atc ggt acg acg 547Val Pro Val Ala Ile Pro Ile Ile Leu Gly Ala Asn Ile Gly Thr Thr

135 140 145atc acc gcg atg ctc gtt gcg ttt tct tat gtg ggt gaa cgc agg gag 595Ile Thr Ala Met Leu Val Ala Phe Ser Tyr Val Gly Glu Arg Arg Glu150155 160 165ttt aag cga gct ttt acg gtt gcc gcc atg cat gtg tgg ttt aac gtg 643Phe Lys Arg Ala Phe Thr Val Ala Ala Met His Val Trp Phe Asn Val

170 175 180ctc gtc att ctt gtt cta ttt gtt gtg gaa ttg ctc ttt cat cca ttc 691Leu Val Ile Leu Val Leu Phe Val Val Glu Leu Leu Phe His Pro Phe

185 190 195cgc aca att agt ggt gcg atc gca acg gag atc aca ctg aca act ggt 739Arg Thr Ile Ser Gly Ala Ile Ala Thr Glu Ile Thr Leu Thr Thr Gly

200 205 210ggc tct ttg cct acc agt ggt gtg atg acc aag att ttt gat ccc cca 787Gly Ser Leu Pro Thr Ser Gly Val Met Thr Lys Ile Phe Asp Pro Pro

215 220 225acc caa ctt ctg ggt atg aat ggt ctt atc ggt tcg atc ggc aat cct 835Thr Gln Leu Leu Gly Met Asn Gly Leu Ile Gly Ser Ile Gly Asn Pro230 235 240 245agt att tcg gcg att gta tgt ctt gtg gtg ggc acc att ctt att ctg 883Ser Ile Ser Ala Ile Val Cys Leu Val Val Gly Thr Ile Leu Ile Leu

250 255 260att tcg gtg cgt gcc atg agt tct cag atc cga acc att acg gca gcg 931Ile Ser Val Arg Ala Met Ser Ser Gln Ile Arg Thr Ile Thr Ala Ala

265 270 275acc gta acc tca att atg gac aag gtg atc aat cca gag aac agc ccc 979Thr Val Thr Ser Ile Met Asp Lys Val Ile Asn Pro Glu Asn Ser Pro

280 285 290aag gcg acg att ctt tcc aat ttc tgg agc ttc att ctt gga gtt ttg 1027Lys Ala Thr Ile Leu Ser Asn Phe Trp Ser Phe Ile Leu Gly Val Leu

295 300 305ttc acg ctc atg gtc actgcc tcg tca gtg acc gtg gct tcc atg cag 1075Phe Thr Leu Met Val Thr Ala Ser Ser Val Thr Val Ala Ser Met Gln310 315 320 325cca gtg gct gcc tct ggt gtc gtt aag caa aag cca ttg ctg ggc gtc 1123Pro Val Ala Ala Ser Gly Val Val Lys Gln Lys Pro Leu Leu Gly Val

330 335 340att ttg ggt gcc aac gtg ggc acc acg gtg acc gca atg ttt gct act 1171Ile Leu Gly Ala Asn Val Gly Thr Thr Val Thr Ala Met Phe Ala Thr

345 350 355ttc gcg att gtc agc gat cag ggt gag ttc gct att cag gct gcg ttg 1219Phe Ala Ile Val Ser Asp Gln Gly Glu Phe Ala Ile Gln Ala Ala Leu

360 365 370atc cac ctc att gtg aac ttc acc ggc gca tta cta gtg ctg tgt att 1267Ile His Leu Ile Val Asn Phe Thr Gly Ala Leu Leu Val Leu Cys Ile

375 380 385ccg cag ctt gcc aat gtg att att cac ttg gcc gag aaa act gcg aac 1315Pro Gln Leu Ala Asn Val Ile Ile His Leu Ala Glu Lys Thr Ala Asn390 395 400 405ctc act gcc cgc agt tac 1333Leu Thr Ala Arg Ser Tyr

410<210>512<211>411<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>512Met Ser Ser Gly Phe Glu Tyr Val Gln His Pro Arg Arg Ala Leu Pro 151015 Pro Pro Ile Pro Glu Arg Lys Gly Pro Ala Ala Ala Phe Leu Pro Gly

20 25 30Thr Phe His Pro Ile Asn Pro Lys Asn Ile Ala Ala Ser His Asp Gln

35 40 45Val Leu Leu Ser Gly Trp Gly Lys Phe Val Arg Trp Leu Leu Val Leu

50 55 60Leu Ser Ile Leu Val Ile Ile Ile Gly Ile Asn Leu Ile Leu Asp Gly 65 70 75 80Val Tyr Gly Phe Gly Thr Phe Ser Thr Thr Gln Met Tyr Gln Val Ala

85 90 95Lys Asp Pro Leu Ile Gly Val Leu Ile Gly Ile Leu Ala Thr Ala Leu

100 105 110Val Gln Ser Ser Thr Thr Thr Thr Thr Leu Thr Val Thr Ala Val Gly

115 120 125Thr Gly Ile Val Ser Val Pro Val Ala Ile Pro Ile Ile Leu Gly Ala

130 135 140Asn Ile Gly Thr Thr Ile Thr Ala Met Leu Val Ala Phe Ser Tyr Val145 150 155 160Gly Glu Arg Arg Glu Phe Lys Arg Ala Phe Thr Val Ala Ala Met His

165 170 175Val Trp Phe Asn Val Leu Val Ile Leu Val Leu Phe Val Val Glu Leu

180 185 190Leu Phe His Pro Phe Arg Thr Ile Ser Gly Ala Ile Ala Thr Glu Ile

195 200 205Thr Leu Thr Thr Gly Gly Ser Leu Pro Thr Ser Gly Val Met Thr Lys

210 215 220Ile Phe Asp Pro Pro Thr Gln Leu Leu Gly Met Asn Gly Leu Ile Gly225 230 235 240Ser Ile Gly Asn Pro Ser Ile Ser Ala Ile Val Cys Leu Val Val Gly

245 250 255Thr Ile Leu Ile Leu Ile Ser Val Arg Ala Met Ser Ser Gln Ile Arg

260 265 270Thr Ile Thr Ala Ala Thr Val Thr Ser Ile Met Asp Lys Val Ile Asn

275 280285Pro Glu Asn Ser Pro Lys Ala Thr Ile Leu Ser Asn Phe Trp Ser Phe

290 295 300Ile Leu Gly Val Leu Phe Thr Leu Met Val Thr Ala Ser Ser Val Thr305 310 315 320Val Ala Ser Met Gln Pro Val Ala Ala Ser Gly Val Val Lys Gln Lys

325 330 335Pro Leu Leu Gly Val Ile Leu Gly Ala Asn Val Gly Thr Thr Val Thr

340 345 350Ala Met Phe Ala Thr Phe Ala Ile Val Ser Asp Gln Gly Glu Phe Ala

355 360 365Ile Gln Ala Ala Leu Ile His Leu Ile Val Asn Phe Thr Gly Ala Leu

370 375 380Leu Val Leu Cys Ile Pro Gln Leu Ala Asn Val Ile Ile His Leu Ala385 390 395 400Glu Lys Thr Ala Asn Leu Thr Ala Arg Ser Tyr

405410<210>513<211>1440<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1417)<223>RXA00941<400>513agccggggtg gccgtttgcg tgtacgggtt ttgcttatcg acgcccactt ctgattttaa 60aggcaaatat tttgtgtcac agcgagtaat cttttcgggc atg aac cta acc cgg 115

Met Asn Leu Thr Arg

1 5aat gac agg ctc gat cga ctg ccc gta act tcc aaa cat aaa aag att 163Asn Asp Arg Leu Asp Arg Leu Pro Val Thr Ser Lys His Lys Lys Ile

10 15 20ctt ggc ggc tca ggt atc ggc tgg gca ttg gat gcc atg gat gtc gga 211Leu Gly Gly Ser Gly Ile Gly Trp Ala Leu Asp Ala Met Asp Val Gly

2530 35ctg atc tct ttc gtc atg gct gcg ttg gcc act cat tgg ggc cta tcc 259Leu Ile Ser Phe Val Met Ala Ala Leu Ala Thr His Trp Gly Leu Ser

40 45 50cct act gaa act tcc ctg ctc gga tcc atc ggt ttc gtt ggc atg gcc 307Pro Thr Glu Thr Ser Leu Leu Gly Ser Ile Gly Phe Val Gly Met Ala

55 60 65atc ggc gct tcg ctg ggc ggt ttg ctg gcg gac aag ttg ggg cgt cga 355Ile Gly Ala Ser Leu Gly Gly Leu Leu Ala Asp Lys Leu Gly Arg Arg 70 75 80 85caa gtt ttt gcg ttg tct ttg cta gtt tat ggc gtt gcc act ggc gcg 403Gln Val Phe Ala Leu Ser Leu Leu Val Tyr Gly Val Ala Thr Gly Ala

90 95 100tcg gcg ctt tca gtg tcg ctg gca atg ttg atg gcg ctg cgc ttc gtc 451Ser Ala Leu Ser Val Ser Leu Ala Met Leu Met Ala Leu Arg Phe Val

105 110 115gtt gga ctt ggc ctg ggc gct gaa ctc ccc gtt gca tcc act ctg att 499Val Gly Leu Gly Leu Gly Ala Glu Leu Pro Val Ala Ser Thr Leu Ile

120 125 130tcc gag ttt tct cca cga aaa gtt cgt ggc cgc atg gtc gtt atc ctg 547Ser Glu Phe Ser Pro Arg Lys Val Arg Gly Arg Met Val Val Ile Leu

135 140 145gag gcg ttt tgg gcg ctg ggc tgg atc atg gct gca atc gtc gga acc 595Glu Ala Phe Trp Ala Leu Gly Trp Ile Met Ala Ala Ile Val Gly Thr150 155 160 165ttt gtc gtg gca gga tcc gat aat ggt tgg cgt tgg gcg tta gct ctt 643Phe Val Val Ala Gly Ser Asp Asn Gly Trp Arg Trp Ala Leu Ala Leu

170 175 180ggc tgt gtc cct gca att tac gcg gtg tat gtc cgt ctc gga ctt cca 691Gly Cys Val Pro Ala Ile Tyr Ala Val Tyr Val Arg Leu Gly Leu Pro

185 190 195gaa tca gta cgt ttc ctg gag aag aaa ggc cgg cac gac gaa gca gaa 739Glu Ser Val Arg Phe Leu Glu Lys Lys Gly Arg His Asp Glu Ala Glu

200 205 210gcc atc gtt gtt tcc ttc gaa gaa gct gcc gct gcc gaa ggt aaa gct 787Ala Ile Val Val Ser Phe Glu Glu Ala Ala Ala Ala Glu Gly Lys Ala

215 220 225gcc gat gcc acc acc gct gtg gtt cat gac aac gct gcc gag ggt tcc 835Ala Asp Ala Thr Thr Ala Val Val His Asp Asn Ala Ala Glu Gly Ser230 235 240 245gta tcc atc tgg tca gct gct ttg cgc aag cgc acc gtc gcg ctg tgg 883Val Ser Ile Trp Ser Ala Ala Leu Arg Lys Arg Thr Val Ala Leu Trp

250 255 260atc gtg tgg ttc tgc atc aac ttg tcc tac tac gga gcc ttc att tgg 931Ile Val Trp Phe Cys Ile Asn Leu Ser Tyr Tyr Gly Ala Phe Ile Trp

265 270 275att cca tcg ctg ctg gtt gcc gac ggt ttc acc ctc gtg aag tct ttc 979Ile Pro Ser Leu Leu Val Ala Asp Gly Phe Thr Leu Val Lys Ser Phe

280 285 290caa ttc act ctg atc atc acc ttg gct cag ctt cca ggc tat gcg gtt 1027Gln Phe Thr Leu Ile Ile Thr Leu Ala Gln Leu Pro Gly Tyr Ala Val

295 300 305gca gcg tgg ttg att gaa aag tgg ggc cgt cgc agc aca ttg gcc acg 1075Ala Ala Trp Leu Ile Glu Lys Trp Gly Arg Arg Ser Thr Leu Ala Thr310 315 320 325ttc ctg gtt ggt tct gct atc tct gca gcg ctc tac ggc ttg gca aat 1123Phe Leu Val Gly Ser Ala Ile Ser Ala Ala Leu Tyr Gly Leu Ala Asn

330 335 340gtg gag tgg cag atc ctg gtc gca ggt tgt tta cta tcc ttc ttc aac 1171Val Glu Trp Gln Ile Leu Val Ala Gly Cys Leu Leu Ser Phe Phe Asn

345 350 355ctg ggc gca tgg ggc gca ctg tat gcc att ggg ccg gag ctt tat ccc 1219Leu Gly Ala Trp Gly Ala Leu Tyr Ala Ile Gly Pro Glu Leu Tyr Pro

360 365 370act aat gtc cgt gga act gga acg ggt gct gcc gcg gga ttc ggg cgc 1267Thr Asn Val Arg Gly Thr Gly Thr Gly Ala Ala Ala Gly Phe Gly Arg

375 380 385att gct tcc atc atc gct ccg ctc att gtt ccg cca gtg att gct ttt 1315Ile Ala Ser Ile Ile Ala Pro Leu Ile Val Pro Pro Val Ile Ala Phe390 395 400 405ggt gga cca att gct ttg ttc gct ctc ttt gcc acc gcg ttt gcg atc 1363Gly Gly Pro Ile Ala Leu Phe Ala Leu Phe Ala Thr Ala Phe Ala Ile

410 415 420gca gcg att gcg gcg ttt acg ctg cct gag cag aag ggt aag tct ctc 1411Ala Ala Ile Ala Ala Phe Thr Leu Pro Glu Gln Lys Gly Lys Ser Leu

425430435 gct gat tagtgagatc cttccaccag ttt 1440Ala Asp<210>514<211>439<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>514Met Asn Leu Thr Arg Asn Asp Arg Leu Asp Arg Leu Pro Val Thr Ser 151015 Lys His Lys Lys Ile Leu Gly Gly Ser Gly Ile Gly Trp Ala Leu Asp

20 25 30Ala Met Asp Val Gly Leu Ile Ser Phe Val Met Ala Ala Leu Ala Thr

35 40 45His Trp Gly Leu Ser Pro Thr Glu Thr Ser Leu Leu Gly Ser Ile Gly

50 55 60Phe Val Gly Met Ala Ile Gly Ala SerLeu Gly Gly Leu Leu Ala Asp 65 70 75 80Lys Leu Gly Arg Arg Gln Val Phe Ala Leu Ser Leu Leu Val Tyr Gly

85 90 95Val Ala Thr Gly Ala Ser Ala Leu Ser Val Ser Leu Ala Met Leu Met

100 105 110Ala Leu Arg Phe Val Val Gly Leu Gly Leu Gly Ala Glu Leu Pro Val

115 120 125Ala Ser Thr Leu Ile Ser Glu Phe Ser Pro Arg Lys Val Arg Gly Arg

130 135 140Met Val Val Ile Leu Glu Ala Phe Trp Ala Leu Gly Trp Ile Met Ala145 150 155 160Ala Ile Val Gly Thr Phe Val Val Ala Gly Ser Asp Asn Gly Trp Arg

165 170 175Trp Ala Leu Ala Leu Gly Cys Val Pro Ala Ile Tyr Ala Val Tyr Val

180 185 190Arg Leu Gly Leu Pro Glu Ser Val Arg Phe Leu Glu Lys Lys Gly Arg

195 200 205His Asp Glu Ala Glu Ala Ile Val Val Ser Phe Glu Glu Ala Ala Ala

210 215 220Ala Glu Gly Lys Ala Ala Asp Ala Thr Thr Ala Val Val His Asp Asn225 230 235 240Ala Ala Glu Gly Ser Val Ser Ile Trp Ser Ala Ala Leu Arg Lys Arg

245 250 255Thr Val Ala Leu Trp Ile Val Trp Phe Cys Ile Asn Leu Ser Tyr Tyr

260 265 270Gly Ala Phe Ile Trp Ile Pro Ser Leu Leu Val Ala Asp Gly Phe Thr

275 280 285Leu Val Lys Ser Phe Gln Phe Thr Leu Ile Ile Thr Leu Ala Gln Leu

290 295 300Pro Gly Tyr Ala Val Ala Ala Trp Leu Ile Glu Lys Trp Gly Arg Arg305 310 315 320Ser Thr Leu Ala Thr Phe Leu Val Gly Ser Ala Ile Ser Ala Ala Leu

325 330 335Tyr Gly Leu Ala Asn Val Glu Trp Gln Ile Leu Val Ala Gly Cys Leu

340 345 350Leu Ser Phe Phe Asn Leu Gly Ala Trp Gly Ala Leu Tyr Ala Ile Gly

355 360 365Pro Glu Leu Tyr Pro Thr Asn Val Arg Gly Thr Gly Thr Gly Ala Ala

370 375 380Ala Gly Phe Gly Arg Ile Ala Ser Ile Ile Ala Pro Leu Ile Val Pro385 390 395 400Pro Val Ile Ala Phe Gly Gly Pro Ile Ala Leu Phe Ala Leu Phe Ala

405 410 415Thr Ala Phe Ala Ile Ala Ala Ile Ala Ala Phe Thr Leu Pro Glu Gln

420 425 430Lys Gly Lys Ser Leu Ala Asp

435<210>515<211>1704<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1681)<223>RXN00449<400>515tcgttggctt acatggtcat tgatgaccgg gctgaatatg tgagaaaatc catcccttct 60ttaagcaagg gagtgaatta cagaaaagga ttgttcagca atg agc aca cct gac 115

Met Ser Thr Pro Asp

1 5att aaa gaa ggc tcg gca gaa tca ccg ggc gaa gta atg gtc gtt gga 163Ile Lys Glu Gly Ser Ala Glu Ser Pro Gly Glu Val Met Val Val Gly

10 15 20gac agg cga gag tgg cgt cga caa gca acc ggc atc att gcc ggc ctc 211Asp Arg Arg Glu Trp Arg Arg Gln Ala Thr Gly Ile Ile Ala Gly Leu

25 30 35gtc tta gcc gcc ctg gtc tat ctt ctc ttc ccc tcg aac tcc gtg gaa 259Val Leu Ala Ala Leu Val Tyr Leu Leu Phe Pro Ser Asn Ser Val Glu

40 45 50acc gtc atg caa tcc agt ggc gtc gat cca gaa act gaa tac acc aac 307Thr Val Met Gln Ser Ser Gly Val Asp Pro Glu Thr Glu Tyr Thr Asn

55 60 65aac gcg atg cgt ctt act gct gca gtc aca atc ttg atg gca gtg tgg 355Asn Ala Met Arg Leu Thr Ala Ala Val Thr Ile Leu Met Ala Val Trp 70 75 80 85tgg atg aca gaa gca atc cca cta gca gca acc gca ctt atc ccg ttg 403Trp Met Thr Glu Ala Ile Pro Leu Ala Ala Thr Ala Leu Ile Pro Leu

90 95 100gtt gca ttc cct gct ttc cag gtt gtg gac ttt ggg aag gca aca gct 451Val Ala Phe Pro Ala Phe Gln Val Val Asp Phe Gly Lys Ala Thr Ala

105 110 115ccg tat gcc aac cct acg agc ttc ctc ttc ttg ggc ggc ttt ctt atg 499Pro Tyr Ala Asn Pro Thr Ser Phe Leu Phe Leu Gly Gly Phe Leu Met

120 125 130gca ctt ggc ctg cag aaa tgg aac cta cac cga cgt atg gct cta gcg 547Ala Leu Gly Leu Gln Lys Trp Asn Leu His Arg Arg Met Ala Leu Ala

135 140 145gtc gtg cta gct gtt ggt act aag cca aag caa ttg gtc ttg ggt ttt 595Val Val Leu Ala Val Gly Thr Lys Pro Lys Gln Leu Val Leu Gly Phe150 155 160 165atg gtg gca act gga ttt ttg tcc atgtgg gtg tct aac act gca acg 643Met Val Ala Thr Gly Phe Leu Ser Met Trp Val Ser Asn Thr Ala Thr

170 175 180gcc gtg gtt atg tta ccg atc ggt atg tcg gta ctg gca ctg acc gct 691Ala Val Val Met Leu Pro Ile Gly Met Ser Val Leu Ala Leu Thr Ala

185 190 195gag act gtg ggc gga atg aaa aac caa aag aaa ttc gcc act gga ctc 739Glu Thr Val Gly Gly Met Lys Asn Gln Lys Lys Phe Ala Thr Gly Leu

200 205 210atg ctg tcc att gct tat tct gct tcc atc ggt tca ctc ggc acc tta 787Met Leu Ser Ile Ala Tyr Ser Ala Ser Ile Gly Ser Leu Gly Thr Leu

215 220 225att ggc acg cca ccc aat gcc ttg ctt gct gcg tat atg tct gaa tcg 835Ile Gly Thr Pro Pro Asn Ala Leu Leu Ala Ala Tyr Met Ser Glu Ser230 235 240 245cat gat atc cac atc gga ttt ggt cag tgg atg att ctt ggt gta cca 883His Asp Ile His Ile Gly Phe Gly Gln Trp Met Ile Leu Gly Val Pro

250 255 260att gct gtc gtc ttc acc atc atc gcg tgg ctt gtg ttg acc acc gtg 931Ile Ala Val Val Phe Thr Ile Ile Ala Trp Leu Val Leu Thr Thr Val

265 270 275ttc aag cca gaa atg aaa gaa atc cct ggc gga cgt gaa ctg atc aaa 979Phe Lys Pro Glu Met Lys Glu Ile Pro Gly Gly Arg Glu Leu Ile Lys

280 285 290cgt gaa atc gct gaa atg ggg ccg tgg act gca cct cag gtc aca gtg 1027Arg Glu Ile Ala Glu Met Gly Pro Trp Thr Ala Pro Gln Val Thr Val

295 300 305ggt gtt att ttt gcg gca gct gca ctg gct tgg gtc ttc att cca tta 1075Gly Val Ile Phe Ala Ala Ala AlaLeu Ala Trp Val Phe Ile Pro Leu310 315 320 325act cta gat tgg acc ggt tcc cag ctc tct atc aat gac tcc ctc att 1123Thr Leu Asp Trp Thr Gly Ser Gln Leu Ser Ile Asn Asp Ser Leu Ile

330 335 340ggc atc gct gcc ggc ctg ctg atg ttt atc gtt ccc gct aac ttt aaa 1171Gly Ile Ala Ala Gly Leu Leu Met Phe Ile Val Pro Ala Asn Phe Lys

345 350 355acc ggc gaa cgc att ctt gat tgg cgt act gca ggc gaa ctt cca tgg 1219Thr Gly Glu Arg Ile Leu Asp Trp Arg Thr Ala Gly Glu Leu Pro Trp

360 365 370gat gtt ctc ttg ctt ttt ggt ggc ggg ctt tca ctt tct gcg atg ttt 1267Asp Val Leu Leu Leu Phe Gly Gly Gly Leu Ser Leu Ser Ala Met Phe

375 380 385acc agc acg gga ctt tcc cta tgg atc ggt gaa cta gct aag gga ctt 1315Thr Ser Thr Gly Leu Ser Leu Trp Ile Gly Glu Leu Ala Lys Gly Leu390 395 400 405gat gcc ctt cca atc ttc att ctc atc ttc gcc att gct gtc ctg gtg 1363Asp Ala Leu Pro Ile Phe Ile Leu Ile Phe Ala Ile Ala Val Leu Val

410 415 420ttg ttc ctg acc gag ttc acc tcc aac acc gca aca gcg gca acc ttc 1411Leu Phe Leu Thr Glu Phe Thr Ser Asn Thr Ala Thr Ala Ala Thr Phe

425 430 435ctg cca atc atg ggt ggc gtc gcc gta ggt atc gga ctg acc gca ggt 1459Leu Pro Ile Met Gly Gly Val Ala Val Gly Ile Gly Leu Thr Ala Gly

440 445 450ggc gag cag aat gtt ctg ctg ctg acc atc cca gtc gca ctg tcc gca 1507Gly Glu Gln Asn Val Leu Leu Leu Thr Ile Pro Val Ala Leu Ser Ala

455 460 465acc tgt gcg ttc atg ctt cca gtg gca acg cct cca aac gcg att gca 1555Thr Cys Ala Phe Met Leu Pro Val Ala Thr Pro Pro Asn Ala Ile Ala470 475 480 485ttc ggc tcc ggc tac att aag atc ggc gaa atg gtc aag ggt ggt ctg 1603Phe Gly Ser Gly Tyr Ile Lys Ile Gly Glu Met Val Lys Gly Gly Leu

490 495 500tgg ctg aac atc atc gca gtc atc ctc att acg att ttc acc tac ttc 1651Trp Leu Asn Ile Ile Ala Val Ile Leu Ile Thr Ile Phe Thr Tyr Phe

505 510 515gta gcg atc cca ctc ttt ggc atc atg ctt taaaagttaa caggcccgca 1701Val Ala Ile Pro Leu Phe Gly Ile Met Leu

520525 gtc1704<210>516<211>527<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>516Met Ser Thr Pro Asp Ile Lys Glu Gly Ser Ala Glu Ser Pro Gly Glu 151015 Val Met Val Val Gly Asp Arg Arg Glu Trp Arg Arg Gln Ala Thr Gly

20 25 30Ile Ile Ala Gly Leu Val Leu Ala Ala Leu Val Tyr Leu Leu Phe Pro

35 40 45Ser Asn Ser Val Glu Thr Val Met Gln Ser Ser Gly Val Asp Pro Glu

50 55 60Thr Glu Tyr Thr Asn Asn Ala Met Arg Leu Thr Ala Ala Val Thr Ile 65 70 75 80Leu Met Ala Val Trp Trp Met Thr Glu Ala Ile Pro Leu Ala Ala Thr

85 90 95Ala Leu Ile Pro Leu Val Ala Phe Pro Ala Phe Gln Val Val Asp Phe

100 105 110Gly Lys Ala Thr Ala Pro Tyr Ala Asn Pro Thr Ser Phe Leu Phe Leu

115 120125Gly Gly Phe Leu Met Ala Leu Gly Leu Gln Lys Trp Asn Leu His Arg

130 135 140Arg Met Ala Leu Ala Val Val Leu Ala Val Gly Thr Lys Pro Lys Gln145 150 155 160Leu Val Leu Gly Phe Met Val Ala Thr Gly Phe Leu Ser Met Trp Val

165 170 175Ser Asn Thr Ala Thr Ala Val Val Met Leu Pro Ile Gly Met Ser Val

180 185 190Leu Ala Leu Thr Ala Glu Thr Val Gly Gly Met Lys Asn Gln Lys Lys

195 200 205Phe Ala Thr Gly Leu Met Leu Ser Ile Ala Tyr Ser Ala Ser Ile Gly

210 215 220Ser Leu Gly Thr Leu Ile Gly Thr Pro Pro Asn Ala Leu Leu Ala Ala225 230 235 240Tyr Met Ser Glu Ser His Asp Ile His Ile Gly Phe Gly Gln Trp Met

245 250 255Ile Leu Gly Val Pro Ile Ala Val Val Phe Thr Ile Ile Ala Trp Leu

260 265 270Val Leu Thr Thr Val Phe Lys Pro Glu Met Lys Glu Ile Pro Gly Gly

275 280 285Arg Glu Leu Ile Lys Arg Glu Ile Ala Glu Met Gly Pro Trp Thr Ala

290 295 300Pro Gln Val Thr Val Gly Val Ile Phe Ala Ala Ala Ala Leu Ala Trp305 310 315 320Val Phe Ile Pro Leu Thr Leu Asp Trp Thr Gly Ser Gln Leu Ser Ile

325 330 335Asn Asp Ser Leu Ile Gly Ile Ala Ala Gly Leu Leu Met Phe Ile Val

340 345 350Pro Ala Asn Phe Lys Thr Gly Glu Arg Ile Leu Asp Trp Arg Thr Ala

355 360 365Gly Glu Leu Pro Trp Asp Val Leu Leu Leu Phe Gly Gly Gly Leu Ser

370 375 380Leu Ser Ala Met Phe Thr Ser Thr Gly Leu Ser Leu Trp Ile Gly Glu385 390 395 400Leu Ala Lys Gly Leu Asp Ala Leu Pro Ile Phe Ile Leu Ile Phe Ala

405 410 415Ile Ala Val Leu Val Leu Phe Leu Thr Glu Phe Thr Ser Asn Thr Ala

420 425 430Thr Ala Ala Thr Phe Leu Pro Ile Met Gly Gly Val Ala Val Gly Ile

435 440 445Gly Leu Thr Ala Gly Gly Glu Gln Asn Val Leu Leu Leu Thr Ile Pro

450 455 460Val Ala Leu Ser Ala Thr Cys Ala Phe Met Leu Pro Val Ala Thr Pro465 470 475 480Pro Asn Ala Ile Ala Phe Gly Ser Gly Tyr Ile Lys Ile Gly Glu Met

485 490 495Val Lys Gly Gly Leu Trp Leu Asn Ile Ile Ala Val Ile Leu Ile Thr

500 505 510Ile Phe Thr Tyr Phe Val Ala Ile Pro Leu Phe Gly Ile Met Leu

515520525<210>517<211>1028<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (1005)<223>FRXA00449<400>517ctg gca ctg acc gct gag act gtg ggc gga atg aaa aac caa aag aaa 48Leu Ala Leu Thr Ala Glu Thr Val Gly Gly Met Lys Asn Gln Lys Lys 151015 ttc gcc act gga ctc atg ctg tcc att gct tat tct gct tcc atc ggt 96Phe Ala Thr Gly Leu Met Leu Ser Ile AlaTyr Ser Ala Ser Ile Gly

20 25 30tca ctc ggc acc tta att ggc acg cca ccc aat gcc ttg ctt gct gcg 144Ser Leu Gly Thr Leu Ile Gly Thr Pro Pro Asn Ala Leu Leu Ala Ala

35 40 45tat atg tct gaa tcg cat gat atc cac atc gga ttt ggt cag tgg atg 192Tyr Met Ser Glu Ser His Asp Ile His Ile Gly Phe Gly Gln Trp Met

50 55 60att ctt ggt gta cca att gct gtc gtc ttc acc atc atc gcg tgg ctt 240Ile Leu Gly Val Pro Ile Ala Val Val Phe Thr Ile Ile Ala Trp Leu 65 70 75 80gtg ttg acc acc gtg ttc aag cca gaa atg aaa gaa atc cct ggc gga 288Val Leu Thr Thr Val Phe Lys Pro Glu Met Lys Glu Ile Pro Gly Gly

85 90 95cgt gaa ctg atc aaa cgt gaa atc gct gaa atg ggg ccg tgg act gca 336Arg Glu Leu Ile Lys Arg Glu Ile Ala Glu Met Gly Pro Trp Thr Ala

100 105 110cct cag gtc aca gtg ggt gtt att ttt gcg gca gct gca ctg gct tgg 384Pro Gln Val Thr Val Gly Val Ile Phe Ala Ala Ala Ala Leu Ala Trp

115 120 125gtc ttc att cca tta act cta gat tgg acc ggt tcc cag ctc tct atc 432Val Phe Ile Pro Leu Thr Leu Asp Trp Thr Gly Ser Gln Leu Ser Ile

130 135 140aat gac tcc ctc att ggc atc gct gcc ggc ctg ctg atg ttt atc gtt 480Asn Asp Ser Leu Ile Gly Ile Ala Ala Gly Leu Leu Met Phe Ile Val145 150 155 160ccc gct aac ttt aaa acc ggc gaa cgc att ctt gat tgg cgt act gca 528Pro Ala Asn Phe Lys Thr Gly Glu Arg Ile Leu Asp Trp Arg Thr Ala

165 170 175ggc gaa ctt cca tgg gat gtt ctc ttg ctt ttt ggt ggc ggg ctt tca 576Gly Glu Leu Pro Trp Asp Val Leu Leu Leu Phe Gly Gly Gly Leu Ser

180 185 190ctt tct gcg atg ttt acc agc acg gga ctt tcc cta tgg atc ggt gaa 624Leu Ser Ala Met Phe Thr Ser Thr Gly Leu Ser Leu Trp Ile Gly Glu

195 200 205cta gct aag gga ctt gat gcc ctt cca atc ttc att ctc atc ttc gcc 672Leu Ala Lys Gly Leu Asp Ala Leu Pro Ile Phe Ile Leu Ile Phe Ala

210 215 220att gct gtc ctg gtg ttg ttc ctg acc gag ttc acc tcc aac acc gca 720Ile Ala Val Leu Val Leu Phe Leu Thr Glu Phe Thr Ser Asn Thr Ala225 230 235 240aca gcg gca acc ttc ctg cca atc atg ggt ggc gtc gcc gta ggt atc 768Thr Ala Ala Thr Phe Leu Pro Ile Met Gly Gly Val Ala Val Gly Ile

245 250 255gga ctg acc gca ggt ggc gag cag aat gtt ctg ctg ctg acc atc cca 816Gly Leu Thr Ala Gly Gly Glu Gln Asn Val Leu Leu Leu Thr Ile Pro

260 265 270gtc gca ctg tcc gca acc tgt gcg ttc atg ctt cca gtg gca acg cct 864Val Ala Leu Ser Ala Thr Cys Ala Phe Met Leu Pro Val Ala Thr Pro

275 280 285cca aac gcg att gca ttc ggc tcc ggc tac att aag atc ggc gaa atg 912Pro Asn Ala Ile Ala Phe Gly Ser Gly Tyr Ile Lys Ile Gly Glu Met

290 295 300gtc aag ggt ggt ctg tgg ctg aac atc atc gca gtc atc ctc att acg 960Val Lys Gly Gly Leu Trp Leu Asn Ile Ile Ala Val Ile Leu Ile Thr305 310 315 320att ttc acc tac ttc gta gcg atc cca ctc ttt ggc atc atg ctt 1005Ile Phe Thr Tyr Phe Val Ala Ile Pro Leu Phe Gly Ile Met Leu

325330335 taaaagttaa caggcccgca gtc 1028<210>518<211>335<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>518Leu Ala Leu Thr Ala Glu Thr Val Gly Gly Met Lys Asn Gln Lys Lys 151015 Phe Ala Thr Gly Leu Met Leu Ser Ile Ala Tyr Ser Ala Ser Ile Gly

20 25 30Ser Leu Gly Thr Leu Ile Gly Thr Pro Pro Asn Ala Leu Leu Ala Ala

35 40 45Tyr Met Ser Glu Ser His Asp Ile His Ile Gly Phe Gly Gln Trp Met

50 55 60Ile Leu Gly Val Pro Ile Ala Val Val Phe Thr Ile Ile Ala Trp Leu 65 70 75 80Val Leu Thr Thr Val Phe Lys Pro Glu Met Lys Glu Ile Pro Gly Gly

85 90 95Arg Glu Leu Ile Lys Arg Glu Ile Ala Glu Met Gly Pro Trp Thr Ala

100 105 110Pro Gln Val Thr Val Gly Val Ile Phe Ala Ala Ala Ala Leu Ala Trp

115 120 125Val Phe Ile Pro Leu Thr Leu Asp Trp Thr Gly Ser Gln Leu Ser Ile

130 135 140Asn Asp Ser Leu Ile Gly Ile Ala Ala Gly Leu Leu Met Phe Ile Val145 150 155 160Pro Ala Asn Phe Lys Thr Gly Glu Arg Ile Leu Asp Trp Arg Thr Ala

165 170 175Gly Glu Leu Pro Trp Asp Val Leu Leu Leu Phe Gly Gly Gly Leu Ser

180 185 190Leu Ser Ala Met Phe Thr Ser Thr Gly Leu Ser Leu Trp Ile Gly Glu

195 200 205Leu Ala Lys Gly Leu Asp Ala Leu Pro Ile Phe Ile Leu Ile Phe Ala

210 215 220Ile Ala Val Leu Val Leu Phe Leu Thr Glu Phe Thr Ser Asn Thr Ala225 230 235 240Thr Ala Ala Thr Phe Leu Pro Ile Met Gly Gly Val Ala Val Gly Ile

245 250 255Gly Leu Thr Ala Gly Gly Glu Gln Asn Val Leu Leu Leu Thr Ile Pro

260 265 270Val Ala Leu Ser Ala Thr Cys Ala Phe Met Leu Pro Val Ala Thr Pro

275 280 285Pro Asn Ala Ile Ala Phe Gly Ser Gly Tyr Ile Lys Ile Gly Glu Met

290 295 300Val Lys Gly Gly Leu Trp Leu Asn Ile Ile Ala Val Ile Leu Ile Thr305 310 315 320Ile Phe Thr Tyr Phe Val Ala Ile Pro Leu Phe Gly Ile Met Leu

325330335<210>519<211>448<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (448)<223>FRXA01755<400>519tcgttggctt acatggtcat tgatgaccgg gctgaatatg tgagaaaatc catcccttct 60ttaagcaagg gagtgaatta cagaaaagga ttgttcagca atg agc aca cct gac 115

Met Ser Thr Pro Asp

1 5att aaa gaa ggc tcg gca gaa tca ccg ggc gaa gta atg gtc gtt gga 163Ile Lys Glu Gly Ser Ala Glu Ser Pro Gly Glu Val Met Val Val Gly

10 15 20gac agg cga gag tgg cgt cga caa gca acc ggc atc att gcc ggc ctc 211Asp Arg Arg Glu Trp Arg Arg Gln Ala Thr Gly Ile Ile Ala Gly Leu

25 30 35gtc tta gcc gcc ctg gtc tat ctt ctc ttc ccc tcg aac tcc gtg gaa 259Val Leu Ala Ala Leu Val Tyr Leu Leu Phe Pro Ser Asn Ser Val Glu

40 45 50acc gtc atg caa tcc agt ggc gtc gat cca gaa act gaa tac acc aac 307Thr Val Met Gln Ser Ser Gly Val Asp Pro Glu Thr Glu Tyr Thr Asn

55 60 65aac gcg atg cgt ctt act gct gca gtc aca atc ttg atg gca gtg tgg 355Asn Ala Met Arg Leu Thr Ala Ala Val Thr Ile Leu Met Ala Val Trp 70 75 80 85tgg atg aca gaa gca atc cca cta gca gca acc gca ctt atc ccg ttg 403Trp Met Thr Glu Ala Ile Pro Leu Ala Ala Thr Ala Leu Ile Pro Leu

90 95 100gtt gca ttc cct gct ttc cag gtt gtg gac ttt ggg aag gca gca 448Val Ala Phe Pro Ala Phe Gln Val Val Asp Phe Gly Lys Ala Ala

105110115<210>520<211>116<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>520Met Ser Thr Pro Asp Ile Lys Glu Gly Ser Ala Glu Ser Pro Gly Glu 151015 Val Met Val Val Gly Asp Arg Arg Glu Trp Arg Arg Gln Ala Thr Gly

20 25 30Ile Ile Ala Gly Leu Val Leu Ala Ala Leu Val Tyr Leu Leu Phe Pro

35 40 45Ser Asn Ser Val Glu Thr Val Met Gln Ser Ser Gly Val Asp Pro Glu

50 55 60Thr Glu Tyr Thr Asn Asn Ala Met Arg Leu Thr Ala Ala Val Thr Ile 65 70 75 80Leu Met Ala Val Trp Trp Met Thr Glu Ala Ile Pro Leu Ala Ala Thr

85 9095Ala Leu Ile Pro Leu Val Ala Phe Pro Ala Phe Gln Val Val Asp Phe

100 105 110Gly Lys Ala Ala

115<210>521<211>912<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (889)<223>RXA00269<400>521tgcgatcttg gtggttgtcg ccatgctgct gccgaggtgg cgtgcgaagt tctccaaggc 60accgaagcct aagcaaccag tagcagtgga ggcttaagac atg tta tcc atc aac 115

Met Leu Ser Ile Asn

1 5gga att tct aag acg ttc ttc ccc ggc act gtg aat gag cgc cgc gcg 163Gly Ile Ser Lys Thr Phe Phe Pro Gly Thr Val Asn Glu Arg Arg Ala

10 15 20ttg cag cag ctc aaa ctc gat atg gct gag ggc gat ttt gtc acc gtc 211Leu Gln Gln Leu Lys Leu Asp Met Ala Glu Gly Asp Phe Val Thr Val

25 30 35atc ggt tct aac ggt gcg ggt aaa tcc acg ctg ctc aac gct gtt tct 259Ile Gly Ser Asn Gly Ala Gly Lys Ser Thr Leu Leu Asn Ala Val Ser

40 45 50ggc cgt ttg ctt gtt gat tcc ggc gag att tcc atc gac ggc aac aag 307Gly Arg Leu Leu Val Asp Ser Gly Glu Ile Ser Ile Asp Gly Asn Lys

55 60 65gta aac aag atg tca gag cac aag cgt gcc cgc tac atc ggc cgc gtt 355Val Asn Lys Met Ser Glu His Lys Arg Ala Arg Tyr Ile Gly Arg Val70 75 80 85ttc cag gat cct ctg gcc ggc acc gcg ccg aat ctc acc att gaa gag 403Phe Gln Asp Pro Leu Ala Gly Thr Ala Pro Asn Leu Thr Ile Glu Glu

90 95100aat ctg gcc atc gcg ttg ctg cgc ggc aag cgc cgt gga ttg ggc ttt 451Asn Leu Ala Ile Ala Leu Leu Arg Gly Lys Arg Arg Gly Leu Gly Phe

105 110 115gca ctg acc tcg aag cgc cgt gag caa ttc aag cag gaa ctt gag cgc 499Ala Leu Thr Ser Lys Arg Arg Glu Gln Phe Lys Gln Glu Leu Glu Arg

120 125 130ctt gag ctg ggt ctg gaa aac agg ctc act gcc aaa gtt ggt ttg ctc 547Leu Glu Leu Gly Leu Glu Asn Arg Leu Thr Ala Lys Val Gly Leu Leu

135 140 145tct ggc ggt cag cgt cag gca ttg tcc ctg ctg atg gct ggt ttt act 595Ser Gly Gly Gln Arg Gln Ala Leu Ser Leu Leu Met Ala Gly Phe Thr150 155 160 165caa cct aaa atc atg ctg ttg gat gag cac acc gca gcg ctt gat cca 643Gln Pro Lys Ile Met Leu Leu Asp Glu His Thr Ala Ala Leu Asp Pro

170 175 180cag cgt gca gag ctt gtg acc acc ttg acc gaa aag atc gtg gca gat 691Gln Arg Ala Glu Leu Val Thr Thr Leu Thr Glu Lys Ile Val Ala Asp

185 190 195gga aat ctg act acg ctt atg gtc acg cac aac atg gaa cag gca att 739Gly Asn Leu Thr Thr Leu Met Val Thr His Asn Met Glu Gln Ala Ile

200 205 210cgc ctg ggc aat cgc ctg atc atg atg cat gaa ggc cag att gtc tac 787Arg Leu Gly Asn Arg Leu Ile Met Met His Glu Gly Gln Ile Val Tyr

215 220 225cag gca gat cag gct acc aag tcg aag ttg act gtg cgc gat ttg ctg 835Gln Ala Asp Gln Ala Thr Lys Ser Lys Leu Thr Val Arg Asp Leu Leu230 235 240 245cag gag ttc gcc aac atc aag ggc gca aca ttg tct gac aag gcg ttc 883Gln Glu Phe Ala Asn Ile Lys Gly Ala Thr Leu Ser Asp Lys Ala Phe

250255260 ctc ggc taaaaagagc ttgctttacg acg 912Leu Gly<210>522<211>263<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>522Met Leu Ser Ile Asn Gly Ile Ser Lys Thr Phe Phe Pro Gly Thr Val 151015 Asn Glu Arg Arg Ala Leu Gln Gln Leu Lys Leu Asp Met Ala Glu Gly

20 25 30Asp Phe Val Thr Val Ile Gly Ser Asn Gly Ala Gly Lys Ser Thr Leu

35 40 45Leu Asn Ala Val Ser Gly Arg Leu Leu Val Asp Ser Gly Glu Ile Ser

50 55 60Ile Asp Gly Asn Lys Val Asn Lys Met Ser Glu His Lys Arg Ala Arg 65 70 75 80Tyr Ile Gly Arg Val Phe Gln Asp Pro Leu Ala Gly Thr Ala Pro Asn

85 90 95Leu Thr Ile Glu Glu Asn Leu Ala Ile Ala Leu Leu Arg Gly Lys Arg

100 105 110Arg Gly Leu Gly Phe Ala Leu Thr Ser Lys Arg Arg Glu Gln Phe Lys

115 120 125Gln Glu Leu Glu Arg Leu Glu Leu Gly Leu Glu Asn Arg Leu Thr Ala

130 135 140Lys Val Gly Leu Leu Ser Gly Gly Gln Arg Gln Ala Leu Ser Leu Leu145 150 155 160Met Ala Gly Phe Thr Gln Pro Lys Ile Met Leu Leu Asp Glu His Thr

165 170 175Ala Ala Leu Asp Pro Gln Arg Ala Glu Leu Val Thr Thr Leu Thr Glu

180 185 190Lys Ile Val Ala Asp Gly Asn Leu Thr Thr Leu Met Val Thr His Asn

195200 205Met Glu Gln Ala Ile Arg Leu Gly Asn Arg Leu Ile Met Met His Glu

210 215 220Gly Gln Ile Val Tyr Gln A1a Asp Gln Ala Thr Lys Ser Lys Leu Thr225 230 235 240Val Arg Asp Leu Leu Gln Glu Phe Ala Asn Ile Lys Gly Ala Thr Leu

245 250 255Ser Asp Lys Ala Phe Leu Gly

260<210>523<211>817<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (817)<223>RXA00369<400>523ggcgggaaat tacaatcagg catcggcgtt gtcgttgatg tttgcgatta tcggtatcgt 60ggcgctcgcg ttgacggtgc gcagccagaa ggagttttag gtg tca tcg atc aaa 115

Val Ser Ser Ile Lys

1 5ttg cgc gat tta agc gtg agc ttc cgc gac gga acc ttc ggg ctg caa 163Leu Arg Asp Leu Ser Val Ser Phe Arg Asp Gly Thr Phe Gly Leu Gln

10 15 20gat atc aat ttg aaa att gag ccg gaa gaa ttt gtg gtg ctc atc ggg 211Asp Ile Asn Leu Lys Ile Glu Pro Glu Glu Phe Val Val Leu Ile Gly

25 30 35ccg tcg ggg tcc ggt aaa acc acc atg ttg ggc acc atc gcg ggg ttt 259Pro Ser Gly Ser Gly Lys Thr Thr Met Leu Gly Thr Ile Ala Gly Phe

40 45 50gtg gag cca agt tcc ggc agt gtg ctc atc gcc ggc gaa gaa atg acg 307Val Glu Pro Ser Ser Gly Ser Val Leu Ile Ala Gly Glu Glu Met Thr

55 60 65cat gtc ccg ccg gag cgc cgt cgc atg ggc atg gtg ttt cag cag cat 355His Val Pro Pro Glu ArgArg Arg Met Gly Met Val Phe Gln Gln His 70 75 80 85gcg gtg tgg ccg cat atg tcg gtc gcc aag aat gtg gga tac ccg ctg 403Ala Val Trp Pro His Met Ser Val Ala Lys Asn Val Gly Tyr Pro Leu

90 95 100gcg cga agt ggt cag aag ggg gcg tcg ata agc aaa cgc gtg gag cgc 451Ala Arg Ser Gly Gln Lys Gly Ala Ser Ile Ser Lys Arg Val Glu Arg

105 110 115acg ctc gcg ctg gtg ggg ctt gag ggg ttc ggc agt cgc aga ccg gcc 499Thr Leu Ala Leu Val Gly Leu Glu Gly Phe Gly Ser Arg Arg Pro Ala

120 125 130agc ctg tct ggt ggt caa cgt cag cgg gtg gcg ctt gcg cgc gcc atc 547Ser Leu Ser Gly Gly Gln Arg Gln Arg Val Ala Leu Ala Arg Ala Ile

135 140 145atc gcc gac ccc acc gtg ctg ctt ctc gac gag gcc ctc tcc gcc ctc 595Ile Ala Asp Pro Thr Val Leu Leu Leu Asp Glu Ala Leu Ser Ala Leu150 155 160 165gac gaa ccg ctg cga gac gct tta cga cgc gaa ctc gta tct ttg acc 643Asp Glu Pro Leu Arg Asp Ala Leu Arg Arg Glu Leu Val Ser Leu Thr

170 175 180cgg cgc gaa ggc ctc act act gtg cac gtg acg cat gac cgc gcc gaa 691Arg Arg Glu Gly Leu Thr Thr Val His Val Thr His Asp Arg Ala Glu

185 190 195gcg atc tcc atc gct gac cgc atc gtc gta ctc ggc aac ggt cga atc 739Ala Ile Ser Ile Ala Asp Arg Ile Val Val Leu Gly Asn Gly Arg Ile

200 205 210caa cag gta gcc acc cct act gag ctc ctt tcc gcc ccc gct act gcc 787Gln Gln Val Ala Thr Pro Thr Glu Leu Leu Ser Ala Pro Ala Thr Ala

215220225gat gtt gcc cga ttc atc gtc gac gcc acc 817Asp Val Ala Arg Phe Ile Val Asp Ala Thr 230235<210>524<211>239<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>524Val Ser Ser Ile Lys Leu Arg Asp Leu Ser Val Ser Phe Arg Asp Gly 151015 Thr Phe Gly Leu Gln Asp Ile Asn Leu Lys Ile Glu Pro Glu Glu Phe

20 25 30Val Val Leu Ile Gly Pro Ser Gly Ser Gly Lys Thr Thr Met Leu Gly

35 40 45Thr Ile Ala Gly Phe Val Glu Pro Ser Ser Gly Ser Val Leu Ile Ala

50 55 60Gly Glu Glu Met Thr His Val Pro Pro Glu Arg Arg Arg Met Gly Met 65 70 75 80Val Phe Gln Gln His Ala Val Trp Pro His Met Ser Val Ala Lys Asn

85 90 95Val Gly Tyr Pro Leu Ala Arg Ser Gly Gln Lys Gly Ala Ser Ile Ser

100 105 110Lys Arg Val Glu Arg Thr Leu Ala Leu Val Gly Leu Glu Gly Phe Gly

115 120 125Ser Arg Arg Pro Ala Ser Leu Ser Gly Gly Gln Arg Gln Arg Val Ala

130 135 140Leu Ala Arg Ala Ile Ile Ala Asp Pro Thr Val Leu Leu Leu Asp Glu145 150 155 160Ala Leu Ser Ala Leu Asp Glu Pro Leu Arg Asp Ala Leu Arg Arg Glu

165 170 175Leu Val Ser Leu Thr Arg Arg Glu Gly Leu Thr Thr Val His Val Thr

180 185 190His Asp Arg Ala Glu Ala Ile Ser Ile Ala Asp Arg Ile Val Val Leu

195 200205Gly Asn Gly Arg Ile Gln Gln Val Ala Thr Pro Thr Glu Leu Leu Ser

210215220 Ala Pro Ala Thr Ala Asp Val Ala Arg Phe Ile Val Asp Ala Thr 225230235<210>525<211>1653<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).)

Met Ile Ser Arg Leu

1 5ctc caa ttg gct aag aaa gta tgg ccg gaa ctt gga gcc tcc acg ctc 163Leu Gln Leu Ala Lys Lys Val Trp Pro Glu Leu Gly Ala Ser Thr Leu

10 15 20ctg cga ctg ctc aat cag cta ctc acc gca gca ctc att gtg ttc ccc 211Leu Arg Leu Leu Asn Gln Leu Leu Thr Ala Ala Leu Ile Val Phe Pro

25 30 35gcc tgg gtg cta agc cgc aaa cca gac atc tcc ctg ctc gcc gtc gcc 259Ala Trp Val Leu Ser Arg Lys Pro Asp Ile Ser Leu Leu Ala Val Ala

40 45 50atc atc atg gcg ctc atc gcg ctg aca gca gct gtc tgt cgc tgg ggt 307Ile Ile Met Ala Leu Ile Ala Leu Thr Ala Ala Val Cys Arg Trp Gly

55 60 65gag cag gta tgc ggc cac cgc gct gcc ttt ggg ctg ctt gcc cac atg 355Glu Gln Val Cys Gly His Arg Ala Ala Phe Gly Leu Leu Ala His Met 70 75 80 85cgc gtt atg ctt tac gac gcc ctc gtc cac aaa ggt tcc ccc tcg ccg 403Arg Val Met Leu Tyr Asp Ala Leu Val His Lys Gly Ser Pro Ser Pro

90 95 100atc cac ggc agc ggt tcg atc atg tct gtt gcc acc cgt gac att aac 451Ile His Gly Ser Gly Ser Ile Met Ser Val Ala Thr Arg Asp Ile Asn

105 110 115tcc atc gaa gta ttc ttc gcg cac acc att ggg cct aca gtc acc gca 499Ser Ile Glu Val Phe Phe Ala His Thr Ile Gly Pro Thr Val Thr Ala

120 125 130gtg ctg ctc agt gcg gga ggc gtg atc acg ctg gca acg ctc gat ccc 547Val Leu Leu Ser Ala Gly Gly Val Ile Thr Leu Ala Thr Leu Asp Pro

135 140 145gtt gct ggt cta att ggt tta ctc ggt gtc ctc atc gcg tgg ttg atc 595Val Ala Gly Leu Ile Gly Leu Leu Gly Val Leu Ile Ala Trp Leu Ile150 155 160 165ccc ttg att gga aaa caa tcc tca agc agt gaa gcc aca tca cgt gga 643Pro Leu Ile Gly Lys Gln Ser Ser Ser Ser Glu Ala Thr Ser Arg Gly

170 175 180cac atc gcc cag cac ctc acc gaa gat gcc gcc ggc agg ctt gaa atc 691His Ile Ala Gln His Leu Thr Glu Asp Ala Ala Gly Arg Leu Glu Ile

185 190 195aac tca cat gga gcg caa gcc aca cgg tta aat gcg ctc gag gtg aaa 739Asn Ser His Gly Ala Gln Ala Thr Arg Leu Asn Ala Leu Glu Val Lys

200 205 210gag caa caa ctg gaa caa gtt gtg acc cga cag ggc ttg atc gtc ggt 787Glu Gln Gln Leu Glu Gln Val Val Thr Arg Gln Gly Leu Ile Val Gly

215 220 225atc cgt cag ggc gca gca ctt tta tgg ccg tgg ata tca gct gtg ttg 835Ile Arg Gln Gly Ala Ala Leu Leu Trp Pro Trp Ile Ser Ala Val Leu230 235 240 245ttg gtt gct ctg gtt cct cat gtg ggc att gtt gca gcc gcg att atc 883Leu Val Ala Leu Val Pro His Val Gly Ile Val Ala Ala Ala Ile Ile

250 255 260ctg ggc atc tcc cct gcg ttg gat gca gtt gag gga ttt gct cgc acc 931Leu Gly IleSer Pro Ala Leu Asp Ala Val Glu Gly Phe Ala Arg Thr

265 270 275atg cct acc gcg tta aac agt gcg cag cgg tat ttc cag atc atc gat 979Met Pro Thr Ala Leu Asn Ser Ala Gln Arg Tyr Phe Gln Ile Ile Asp

280 285 290gcc cct gtt gct atc gct gaa cct gac gag ccg aag cct ttg ccc aaa 1027Ala Pro Val Ala Ile Ala Glu Pro Asp Glu Pro Lys Pro Leu Pro Lys

295 300 305ggc ccg ctt aag ctg cga att tct aga gtt cca gtc agc gca aag ggc 1075Gly Pro Leu Lys Leu Arg Ile Ser Arg Val Pro Val Ser Ala Lys Gly310 315 320 325acc gtg tct tta gag gtt gca gct ggt gaa cac atc ggc atc atc gga 1123Thr Val Ser Leu Glu Val Ala Ala Gly Glu His Ile Gly Ile Ile Gly

330 335 340tcc agc ggt agt gga aaa tcc act ttg gcc aaa ctc atc ctc aag ctg 1171Ser Ser Gly Ser Gly Lys Ser Thr Leu Ala Lys Leu Ile Leu Lys Leu

345 350 355gcg caa cta cgg tct gga acc atc acc atc ggt ggt gtt gat atc gca 1219Ala Gln Leu Arg Ser Gly Thr Ile Thr Ile Gly Gly Val Asp Ile Ala

360 365 370gag gtt tca tcg gcg gag ctt cgc aaa tcc gtc acg ctg gtt gag cag 1267Glu Val Ser Ser Ala Glu Leu Arg Lys Ser Val Thr Leu Val Glu Gln

375 380 385aaa tct gtg ctg ttt aga gca agc gtg ctg gag aat tta cgg atg ggc 1315Lys Ser Val Leu Phe Arg Ala Ser Val Leu Glu Asn Leu Arg Met Gly390 395 400 405aat cca gag ctg tct gaa gat gaa gca agg gaa gcc ttg agg ttg gcg 1363Asn Pro Glu Leu Ser Glu Asp Glu Ala Arg Glu Ala Leu Arg Leu Ala

410 415 420tcg ata agc gaa ctg cct tta gat gct gac gcc ctg cgc cta tct ggc 1411Ser Ile Ser Glu Leu Pro Leu Asp Ala Asp Ala Leu Arg Leu Ser Gly

425 430 435gga cag caa caa cgg ctc tgc ctg gcg cgt gct ttg gca cgc acc cct 1459Gly Gln Gln Gln Arg Leu Cys Leu Ala Arg Ala Leu Ala Arg Thr Pro

440 445 450cag gta ctg att gtc gat gaa gcc acc agc cac caa gat gcg ctc aat 1507Gln Val Leu Ile Val Asp Glu Ala Thr Ser His Gln Asp Ala Leu Asn

455 460 465caa gcg gat ctt tcc cag act ctg gcc acg ctt aaa gac acc acg gtg 1555Gln Ala Asp Leu Ser Gln Thr Leu Ala Thr Leu Lys Asp Thr Thr Val470 475 480 485atc atc att gcg cac cgc aca gct gca tta acc cat gtg gat cgg ata 1603Ile Ile Ile Ala His Arg Thr Ala Ala Leu Thr His Val Asp Arg Ile

490 495 500att gac ctg gaa gaa atc aaa aat ccc tgatccttaa cgcggatcag 1650Ile Asp Leu Glu Glu Ile Lys Asn Pro

505510 ggg1653<210>526<211>510<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>526Met Ile Ser Arg Leu Leu Gln Leu Ala Lys Lys Val Trp Pro Glu Leu 151015 Gly Ala Ser Thr Leu Leu Arg Leu Leu Asn Gln Leu Leu Thr Ala Ala

20 25 30Leu Ile Val Phe Pro Ala Trp Val Leu Ser Arg Lys Pro Asp Ile Ser

35 40 45Leu Leu Ala Val Ala Ile Ile Met Ala Leu Ile Ala Leu Thr Ala Ala

50 55 60Val Cys Arg Trp Gly Glu Gln Val Cys Gly His Arg Ala Ala Phe Gly 65 7075 80Leu Leu Ala His Met Arg Val Met Leu Tyr Asp Ala Leu Val His Lys

85 90 95Gly Ser Pro Ser Pro Ile His Gly Ser Gly Ser Ile Met Ser Val Ala

100 105 110Thr Arg Asp Ile Asn Ser Ile Glu Val Phe Phe Ala His Thr Ile Gly

115 120 125Pro Thr Val Thr Ala Val Leu Leu Ser Ala Gly Gly Val Ile Thr Leu

130 135 140Ala Thr Leu Asp Pro Val Ala Gly Leu Ile Gly Leu Leu Gly Val Leu145 150 155 160Ile Ala Trp Leu Ile Pro Leu Ile Gly Lys Gln Ser Ser Ser Ser Glu

165 170 175Ala Thr Ser Arg Gly His Ile Ala Gln His Leu Thr Glu Asp Ala Ala

180 185 190Gly Arg Leu Glu Ile Asn Ser His Gly Ala Gln Ala Thr Arg Leu Asn

195 200 205Ala Leu Glu Val Lys Glu Gln Gln Leu Glu Gln Val Val Thr Arg Gln

210 215 220Gly Leu Ile Val Gly Ile Arg Gln Gly Ala Ala Leu Leu Trp Pro Trp225 230 235 240Ile Ser Ala Val Leu Leu Val Ala Leu Val Pro His Val Gly Ile Val

245 250 255Ala Ala Ala Ile Ile Leu Gly Ile Ser Pro Ala Leu Asp Ala Val Glu

260 265 270Gly Phe Ala Arg Thr Met Pro Thr Ala Leu Asn Ser Ala Gln Arg Tyr

275 280 285Phe Gln Ile Ile Asp Ala Pro Val Ala Ile Ala Glu Pro Asp Glu Pro

290295 300Lys Pro Leu Pro Lys Gly Pro Leu Lys Leu Arg Ile Ser Arg Val Pro305 310 315 320Val Ser Ala Lys Gly Thr Val Ser Leu Glu Val Ala Ala Gly Glu His

325 330 335Ile Gly Ile Ile Gly Ser Ser Gly Ser Gly Lys Ser Thr Leu Ala Lys

340 345 350Leu Ile Leu Lys Leu Ala Gln Leu Arg Ser Gly Thr Ile Thr Ile Gly

355 360 365Gly Val Asp Ile Ala Glu Val Ser Ser Ala Glu Leu Arg Lys Ser Val

370 375 380Thr Leu Val Glu Gln Lys Ser Val Leu Phe Arg Ala Ser Val Leu Glu385 390 395 400Asn Leu Arg Met Gly Asn Pro Glu Leu Ser Glu Asp Glu Ala Arg Glu

405 410 415Ala Leu Arg Leu Ala Ser Ile Ser Glu Leu Pro Leu Asp Ala Asp Ala

420 425 430Leu Arg Leu Ser Gly Gly Gln Gln Gln Arg Leu Cys Leu Ala Arg Ala

435 440 445Leu Ala Arg Thr Pro Gln Val Leu Ile Val Asp Glu Ala Thr Ser His

450 455 460Gln Asp Ala Leu Asn Gln Ala Asp Leu Ser Gln Thr Leu Ala Thr Leu465 470 475 480Lys Asp Thr Thr Val Ile Ile Ile Ala His Arg Thr Ala Ala Leu Thr

485 490 495His Val Asp Arg Ile Ile Asp Leu Glu Glu Ile Lys Asn Pro

500505510<210>527<211>1142<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1).<1119)<223>RXA01399<400>527att ctc agc ccc gca acc gca ctt gtc ctg gcg att gga ttg att gct 48Ile Leu Ser Pro Ala Thr Ala Leu Val Leu Ala Ile Gly Leu Ile Ala 151015 gct gca att atc cct ccc ctg ctt gct gct cgc gga gtt aaa aca gcc 96Ala Ala Ile Ile Pro Pro Leu Leu Ala Ala Arg Gly Val Lys Thr Ala<400>

20 25 30gaa gcc cgg cgc gct gaa tcc agc gaa gcc tac ttg agt tcc ttg gat 144Glu Ala Arg Arg Ala Glu Ser Ser Glu Ala Tyr Leu Ser Ser Leu Asp

35 40 45cag gtg ctg tcc aac cag gcg gcg ctt cgt gtt cgt ggt gaa atg ccg 192Gln Val Leu Ser Asn Gln Ala Ala Leu Arg Val Arg Gly Glu Met Pro

50 55 60gcc gct ctg tcc aag gcg gat gtg gct gcg cgt tcc tat tct tct tca 240Ala Ala Leu Ser Lys Ala Asp Val Ala Ala Arg Ser Tyr Ser Ser Ser 65 70 75 80ctg gag gca ggc gcg aaa gac act gcc att ggc gca gcg agt tcc ctg 288Leu Glu Ala Gly Ala Lys Asp Thr Ala Ile Gly Ala Ala Ser Ser Leu

85 90 95tgg att cac ggt ttc act gtc att ggt gtg ctc atg gtt tcc gcg tca 336Trp Ile His Gly Phe Thr Val Ile Gly Val Leu Met Val Ser Ala Ser

100 105 110ctg tat gca gat gga agc cat tca ccg cag tgg ttt ggt gtg ttg gtg 384Leu Tyr Ala Asp Gly Ser His Ser Pro Gln Trp Phe Gly Val Leu Val

115 120 125ctg ctt tca ctc gca gct ttc gag gct gtc tct gtt ctc ccc gat gct 432Leu Leu Ser Leu Ala Ala Phe Glu Ala Val Ser Val Leu Pro Asp Ala

130 135 140gcg att gct cgt acc cgc gcc gca gat gcc acc agg agg ctt gcg gaa 480Ala Ile Ala Arg Thr Arg Ala Ala Asp Ala Thr Arg Arg Leu Ala Glu145 150 155 160atc tcg gcg ctg cca gaa tct gtc tct ctt gag ctt cgc acg gcc tct 528Ile Ser Ala Leu Pro Glu Ser Val Ser Leu Glu Leu Arg Thr Ala Ser

165 170 175gac cag ccc gta tta cgc gcc gag aat cta gtt tat gga tgg gac agc 576Asp Gln Pro Val Leu Arg Ala Glu Asn Leu Val Tyr Gly Trp Asp Ser

180 185 190gac cta ggc acg agc aac ctg gat ctc acc ttt ggt tca cga cat gaa 624Asp Leu Gly Thr Ser Asn Leu Asp Leu Thr Phe Gly Ser Arg His Glu

195 200 205atc atc gca ccc tct gga act ggc aaa acg acc ctg ctg ctc aca ctt 672Ile Ile Ala Pro Ser Gly Thr Gly Lys Thr Thr Leu Leu Leu Thr Leu

210 215 220gcg ggg ctg ttg gaa cct cgt gga ggc caa gtg ctt atc gac ggc acc 720Ala Gly Leu Leu Glu Pro Arg Gly Gly Gln Val Leu Ile Asp Gly Thr225 230 235 240aat cct tcc gag ttg aaa aac gcc gtg ctg ttc agt cca gaa gat gcc 768Asn Pro Ser Glu Leu Lys Asn Ala Val Leu Phe Ser Pro Glu Asp Ala

245 250 255cac att ttt gcc acc act gtc cga gat aac tta gca ctc gga gca ccg 816His Ile Phe Ala Thr Thr Val Arg Asp Asn Leu Ala Leu Gly Ala Pro

260 265 270gaa gca acc gac gcg gaa atg aca tcg atc ctg gaa cat gtt ggt ttg 864Glu Ala Thr Asp Ala Glu Met Thr Ser Ile Leu Glu His Val Gly Leu

275 280 285tca gag tgg gtt caa ggt tta ccc gat ggt ctt ggc act gtc ctt gat 912Ser Glu Trp Val Gln Gly Leu Pro Asp Gly Leu Gly Thr Val Leu Asp

290295 300tca ggt gcc gat agt ctc tcg gga ggt cag cgc cgc cgc ctg ctc ctt 960Ser Gly Ala Asp Ser Leu Ser Gly Gly Gln Arg Arg Arg Leu Leu Leu305 310 315 320gcc cgc gta cta cta agt gat gca cca att ctg ctt ttg gat gaa ccc 1008Ala Arg Val Leu Leu Ser Asp Ala Pro Ile Leu Leu Leu Asp Glu Pro

325 330 335acc gag cac ctc gac act gca ggc tcc tct gaa atc ttg tct atg ctg 1056Thr Glu His Leu Asp Thr Ala Gly Ser Ser Glu Ile Leu Ser Met Leu

340 345 350gcc tcc gat gaa ctc cct ggt aaa aga gct agg aga acc gta gtg att 1104Ala Ser Asp Glu Leu Pro Gly Lys Arg Ala Arg Arg Thr Val Val Ile

355 360 365gtg agg cat gtg agg taattttgcc ccgctgtctt ctg 1142Val Arg His Val Arg

370<210>528<211>373<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>528Ile Leu Ser Pro Ala Thr Ala Leu Val Leu Ala Ile Gly Leu Ile Ala 151015 Ala Ala Ile Ile Pro Pro Leu Leu Ala Ala Arg Gly Val Lys Thr Ala

20 25 30Glu Ala Arg Arg Ala Glu Ser Ser Glu Ala Tyr Leu Ser Ser Leu Asp

35 40 45Gln Val Leu Ser Asn Gln Ala Ala Leu Arg Val Arg Gly Glu Met Pro

50 55 60Ala Ala Leu Ser Lys Ala Asp Val Ala Ala Arg Ser Tyr Ser Ser Ser 65 70 75 80Leu Glu Ala Gly Ala Lys Asp Thr Ala Ile Gly Ala Ala Ser Ser Leu

85 90 95Trp Ile His Gly Phe Thr Val Ile Gly Val Leu Met Val Ser Ala Ser

100 105 110Leu Tyr Ala Asp Gly Ser His Ser Pro Gln Trp Phe Gly Val Leu Val

115 120 125Leu Leu Ser Leu Ala Ala Phe Glu Ala Val Ser Val Leu Pro Asp Ala

130 135 140Ala Ile Ala Arg Thr Arg Ala Ala Asp Ala Thr Arg Arg Leu Ala Glu145 150 155 160Ile Ser Ala Leu Pro Glu Ser Val Ser Leu Glu Leu Arg Thr Ala Ser

165 170 175Asp Gln Pro Val Leu Arg Ala Glu Asn Leu Val Tyr Gly Trp Asp Ser

180 185 190Asp Leu Gly Thr Ser Asn Leu Asp Leu Thr Phe Gly Ser Arg His Glu

195 200 205Ile Ile Ala Pro Ser Gly Thr Gly Lys Thr Thr Leu Leu Leu Thr Leu

210 215 220Ala Gly Leu Leu Glu Pro Arg Gly Gly Gln Val Leu Ile Asp Gly Thr225 230 235 240Asn Pro Ser Glu Leu Lys Asn Ala Val Leu Phe Ser Pro Glu Asp Ala

245 250 255His Ile Phe Ala Thr Thr Val Arg Asp Asn Leu Ala Leu Gly Ala Pro

260 265 270Glu Ala Thr Asp Ala Glu Met Thr Ser Ile Leu Glu His Val Gly Leu

275 280 285Ser Glu Trp Val Gln Gly Leu Pro Asp Gly Leu Gly Thr Val Leu Asp

290 295 300Ser Gly Ala Asp Ser Leu Ser Gly Gly Gln Arg Arg Arg Leu Leu Leu305 310 315 320Ala Arg Val Leu Leu Ser Asp Ala Pro Ile Leu Leu Leu Asp Glu Pro

325 330 335Thr Glu His Leu Asp Thr Ala Gly Ser Ser Glu Ile Leu Ser Met Leu

340 345 350Ala Ser Asp Glu Leu Pro Gly Lys Arg Ala Arg Arg Thr Val Val Ile

355 360 365Val Arg His Val Arg

370<210>529<211>1368<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1345)<223>RXA01339<400>529gagaaggcgg aaccgaagga atcgaagaat atctctccgt gcgttacctc gctttgccgt 60gacacatgag ctgtccggtg aataacccga aggaaaaaac atg act acc gaa tca 115

Met Thr Thr Glu Ser

1 5ata gtt gcg cac aat gct gca ggt aca gca cct cag aat gtg tcc tct 163Ile Val Ala His Asn Ala Ala Gly Thr Ala Pro Gln Asn Val Ser Ser

10 15 20gct aag aag aag tac ctc agc gtt gcc caa ggc gtt gcc ctt atc tac 211Ala Lys Lys Lys Tyr Leu Ser Val Ala Gln Gly Val Ala Leu Ile Tyr

25 30 35gga acc aac atc ggc gcc ggt gtg ctc agc ctc cca tac gct gcc cgc 259Gly Thr Asn Ile Gly Ala Gly Val Leu Ser Leu Pro Tyr Ala Ala Arg

40 45 50aac ggt ggt ttc ctc gcc ctg gtt gtt gcc ctg ctc att gcg gga aca 307Asn Gly Gly Phe Leu Ala Leu Val Val Ala Leu Leu Ile Ala Gly Thr

55 60 65ctg acc acc atc tcc atg ctc tac atc gcc gaa gta tcc ctg cgc acc 355Leu Thr Thr Ile Ser Met Leu Tyr Ile Ala Glu Val Ser Leu Arg Thr 70 75 80 85aag aag cca ctg cag ctt tcc ggc ctg gca gaa aaa tac ctg ggg cag 403Lys Lys Pro Leu Gln Leu Ser Gly Leu Ala Glu Lys Tyr Leu Gly Gln

90 95 100tgg ggc cgc tgg ctg gtg ttc att gcc att gtg gtc aac agc gtg ggt 451Trp Gly Arg Trp Leu Val Phe Ile Ala Ile Val Val Asn Ser Val Gly

105 110 115gca ctg att gcc tac gca tca gga tcc ggc att ttg ata ggc aac ctc 499Ala Leu Ile Ala Tyr Ala Ser Gly Ser Gly Ile Leu Ile Gly Asn Leu

120 125 130acc ggc ctg cca cca atc gtg ggc acc ctt gga ttc ttt gtt tta ggc 547Thr Gly Leu Pro Pro Ile Val Gly Thr Leu Gly Phe Phe Val Leu Gly

135 140 145acc ttg atc atg tgg aaa ggc ctg cac acg gca agc ttc gtg gag gca 595Thr Leu Ile Met Trp Lys Gly Leu His Thr Ala Ser Phe Val Glu Ala150 155 160 165ttg atc acc act ggc atg gca acg atc atc atc gtg ctg tgt gga tgg 643Leu Ile Thr Thr Gly Met Ala Thr Ile Ile Ile Val Leu Cys Gly Trp

170 175 180aca gtg ctt ggc cct gga att tcc gca gac aac ctg atc gtg ttc cac 691Thr Val Leu Gly Pro Gly Ile Ser Ala Asp Asn Leu Ile Val Phe His

185 190 195cca ttc ttc atc gtt ccg atc atg aac ctc gcg gtc ttt acc ttc ctt 739Pro Phe Phe Ile Val Pro Ile Met Asn Leu Ala Val Phe Thr Phe Leu

200 205 210gcc caa tat gtg gtt cca gaa atc gca cga gga gtt aac cct gcc acc 787Ala Gln Tyr Val Val Pro Glu Ile Ala Arg Gly Val Asn Pro Ala Thr

215 220 225ccg aag gca gtg cca cgc gcg atc atc atc ggc atg gtc gca act ggt 835Pro Lys Ala Val Pro ArgAla Ile Ile Ile Gly Met Val Ala Thr Gly230 235 240 245gtc acc ctg gca gct gta cca ttc gcg gca cta ggg ctt ctg ggc aca 883Val Thr Leu Ala Ala Val Pro Phe Ala Ala Leu Gly Leu Leu Gly Thr

250 255 260ggc gtc agt gaa gtt gtc acc atc tcc tgg ggc gaa gca ctc gcc cca 931Gly Val Ser Glu Val Val Thr Ile Ser Trp Gly Glu Ala Leu Ala Pro

265 270 275gtg gcc tat tac atg gcc aat gcc ttc gca cta ttg gcc atg ttc act 979Val Ala Tyr Tyr Met Ala Asn Ala Phe Ala Leu Leu Ala Met Phe Thr

280 285 290tca ttc atc gcc att gga ttc acc gcg atg cgc aac gta cta gat att 1027Ser Phe Ile Ala Ile Gly Phe Thr Ala Met Arg Asn Val Leu Asp Ile

295 300 305ggc cac tgg cca caa cac gga tgg cag cga tcc gtt gct gtc gga cta 1075Gly His Trp Pro Gln His Gly Trp Gln Arg Ser Val Ala Val Gly Leu310 315 320 325act gtt ctt cca cca ctg gca att tca ctt gcg gga tta ggc gga ttc 1123Thr Val Leu Pro Pro Leu Ala Ile Ser Leu Ala Gly Leu Gly Gly Phe

330 335 340gtg gca gca ctg agc tac gcc gga gga ttt gcc gga gca atc atg tcc 1171Val Ala Ala Leu Ser Tyr Ala Gly Gly Phe Ala Gly Ala Ile Met Ser

345 350 355atc atc ccc gtg ctg ttg ctg cgc aac tcc cgc aag agt ggc gac caa 1219Ile Ile Pro Val Leu Leu Leu Arg Asn Ser Arg Lys Ser Gly Asp Gln

360 365 370gaa cca gtg tgg aaa gcc acc tgg caa gcg cac ccc atc ttc cag atc 1267Glu Pro Val Trp Lys Ala Thr Trp Gln Ala His Pro Ile Phe Gln Ile

375 380385ctg ttg att gtg gtg tac tcc ctg gcg ttt gtg tac tcg gtt ctc gcg 1315Leu Leu Ile Val Val Tyr Ser Leu Ala Phe Val Tyr Ser Val Leu Ala390 395 400 405atc gtc gga tta atg cct gcg ggt tgg gca tagtcacttc ctgttgtggc 1365Ile Val Gly Leu Met Pro Ala Gly Trp Ala

410415 tgc1368<210>530<211>415<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>530Met Thr Thr Glu Ser Ile Val Ala His Asn Ala Ala Gly Thr Ala Pro 151015 Gln Asn Val Ser Ser Ala Lys Lys Lys Tyr Leu Ser Val Ala Gln Gly

20 25 30Val Ala Leu Ile Tyr Gly Thr Asn Ile Gly Ala Gly Val Leu Ser Leu

35 40 45Pro Tyr Ala Ala Arg Asn Gly Gly Phe Leu Ala Leu Val Val Ala Leu

50 55 60Leu Ile Ala Gly Thr Leu Thr Thr Ile Ser Met Leu Tyr Ile Ala Glu 65 70 75 80Val Ser Leu Arg Thr Lys Lys Pro Leu Gln Leu Ser Gly Leu Ala Glu

85 90 95Lys Tyr Leu Gly Gln Trp Gly Arg Trp Leu Val Phe Ile Ala Ile Val

100 105 110Val Asn Ser Val Gly Ala Leu Ile Ala Tyr Ala Ser Gly Ser Gly Ile

115 120 125Leu Ile Gly Asn Leu Thr Gly Leu Pro Pro Ile Val Gly Thr Leu Gly

130 135 140Phe Phe Val Leu Gly Thr Leu Ile Met Trp Lys Gly Leu His Thr Ala145 150 155 160Ser Phe Val Glu Ala Leu Ile Thr Thr Gly Met Ala Thr Ile Ile Ile

165 170 175Val Leu Cys Gly Trp Thr Val Leu Gly Pro Gly Ile Ser Ala Asp Asn

180 185 190Leu Ile Val Phe His Pro Phe Phe Ile Val Pro Ile Met Asn Leu Ala

195 200 205Val Phe Thr Phe Leu Ala Gln Tyr Val Val Pro Glu Ile Ala Arg Gly

210 215 220Val Asn Pro Ala Thr Pro Lys Ala Val Pro Arg Ala Ile Ile Ile Gly225 230 235 240Met Val Ala Thr Gly Val Thr Leu Ala Ala Val Pro Phe Ala Ala Leu

245 250 255Gly Leu Leu Gly Thr Gly Val Ser Glu Val Val Thr Ile Ser Trp Gly

260 265 270Glu Ala Leu Ala Pro Val Ala Tyr Tyr Met Ala Asn Ala Phe Ala Leu

275 280 285Leu Ala Met Phe Thr Ser Phe Ile Ala Ile Gly Phe Thr Ala Met Arg

290 295 300Asn Val Leu Asp Ile Gly His Trp Pro Gln His Gly Trp Gln Arg Ser305 310 315 320Val Ala Val Gly Leu Thr Val Leu Pro Pro Leu Ala Ile Ser Leu Ala

325 330 335Gly Leu Gly Gly Phe Val Ala Ala Leu Ser Tyr Ala Gly Gly Phe Ala

340 345 350Gly Ala Ile Met Ser Ile Ile Pro Val Leu Leu Leu Arg Asn Ser Arg

355 360 365Lys Ser Gly Asp Gln Glu Pro Val Trp Lys Ala Thr Trp Gln Ala His

370 375 380Pro Ile Phe Gln Ile Leu Leu Ile Val Val Tyr Ser Leu Ala Phe Val385 390 395 400TyrSer Val Leu Ala Ile yal Gly Leu Met Pro Ala Gly Trp Ala

405410415<210>531<211>1452<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1429)<223>RXA02527<400>531attggagcaa tcttttaatc aagttgggaa ttccagcgtt gattgtggtt gccatgtggt 60ttgcccgcac cctgaagcac tcacggatca agcgtggcgg atg ttt ggc ctg ttc 115

Met Phe Gly Leu Phe

1 5atc gcg acg att gtg gcg att att ctc aag cca atg cca atg ggt gcc 163Ile Ala Thr Ile Val Ala Ile Ile Leu Lys Pro Met Pro Met Gly Ala

10 15 20gtg aca att atc ggc atg atc gcc gcg gtg ttg act ggt ttg gtg ccg 211Val Thr Ile Ile Gly Met Ile Ala Ala Val Leu Thr Gly Leu Val Pro

25 30 35ttg acg gcg tct tct gat gat ccc ggc gcg gtg tat ggc ctt att ggt 259Leu Thr Ala Ser Ser Asp Asp Pro Gly Ala Val Tyr Gly Leu Ile Gly

40 45 50ttc agt aac ggc acc att tgg ctg att gtg atg gcg ttc ctg att tcg 307Phe Ser Asn Gly Thr Ile Trp Leu Ile Val Met Ala Phe Leu Ile Ser

55 60 65cgt gga ttc atc aag acg ggg ctt gga cgt cga ata gcg ttg ttc ttt 355Arg Gly Phe Ile Lys Thr Gly Leu Gly Arg Arg Ile Ala Leu Phe Phe 70 75 80 85gtg tct aaa gtc ggc gga aaa atg ctg ggt gtg acc tat ggt ttg gcg 403Val Ser Lys Val Gly Gly Lys Met Leu Gly Val Thr Tyr Gly Leu Ala

90 95 100ctc gct gat ttg gtg ttg gct cct gcg att cca tca gca act gcc cga 451Leu Ala Asp Leu Val LeuAla Pro Ala Ile Pro Ser Ala Thr Ala Arg

105 110 115ggt ggt ggc att atg gct ccg att atg aag tcg gtg gca ttg act tat 499Gly Gly Gly Ile Met Ala Pro Ile Met Lys Ser Val Ala Leu Thr Tyr

120 125 130gat tcc act cct ggc cca act cgt cgc agg get ggc gcg ttc ttg gcg 547Asp Ser Thr Pro Gly Pro Thr Arg Arg Arg Ala Gly Ala Phe Leu Ala

135 140 145ctg aat gtg gga cag gta aat gcg att acg tgc gcg atg ttt cta act 595Leu Asn Val Gly Gln Val Asn Ala Ile Thr Cys Ala Met Phe Leu Thr150 155 160 165gca atg gca gga aac ccc ttg atc gcc tct ttg gct tcg cag atg gat 643Ala Met Ala Gly Asn Pro Leu Ile Ala Ser Leu Ala Ser Gln Met Asp

170 175 180gtc aat atc acg tgg aca aac tgg gct gtg ggt gcg att gtg cct ggt 691Val Asn Ile Thr Trp Thr Asn Trp Ala Val Gly Ala Ile Val Pro Gly

185 190 195ctg gtg gcg ctt att gtg gtg ccg tgg gtg gta tac aag atc tat cca 739Leu Val Ala Leu Ile Val Val Pro Trp Val Val Tyr Lys Ile Tyr Pro

200 205 210cct gag ttg aag gac acc cct gag gtc aag aaa atg gct tct gat gag 787Pro Glu Leu Lys Asp Thr Pro Glu Val Lys Lys Met Ala Ser Asp Glu

215 220 225ctc aag caa ttg ggt ggg ttt act tat ggt gag aag gtg ctg gcg gga 835Leu Lys Gln Leu Gly Gly Phe Thr Tyr Gly Glu Lys Val Leu Ala Gly230 235 240 245acc ttt gtt gtg ttg ctg ctg ctc tgg aca ggt ggc gat ttg gtc ttg 883Thr Phe Val Val Leu Leu Leu Leu Trp Thr Gly Gly Asp Leu Val Leu

250255 260gga atc tcg gca act acc acc gct ttc gtt ggc gtc atc atc ttg cta 931Gly Ile Ser Ala Thr Thr Thr Ala Phe Val Gly Val Ile Ile Leu Leu

265 270 275gtg gct cac gtg ctg acg tgg gag gac atc att caa gaa aag act gcg 979Val Ala His Val Leu Thr Trp Glu Asp Ile Ile Gln Glu Lys Thr Ala

280 285 290tgg gac acc atg gtg tgg ttc gcg gtg cta tac atg atg gca aca gcg 1027Trp Asp Thr Met Val Trp Phe Ala Val Leu Tyr Met Met Ala Thr Ala

295 300 305tta tcg cag tac gga ttc atc gca tgg atc tct gag gta att gct tcc 1075Leu Ser Gln Tyr Gly Phe Ile Ala Trp Ile Ser Glu Val Ile Ala Ser310 315 320 325agt ttg ggt ggc atg aac tgg gtc gtt gct ttg gtt gtg ttg gtg ctg 1123Ser Leu Gly Gly Met Asn Trp Val Val Ala Leu Val Val Leu Val Leu

330 335 340att tac ttc ttc agt cac tat ttc ttt gcc tcg gca aca gcg cat att 1171Ile Tyr Phe Phe Ser His Tyr Phe Phe Ala Ser Ala Thr Ala His Ile

345 350 355tct gcg atg tac ttg gcc ttc ctg ggt gct gcg att gcg att ggt gca 1219Ser Ala Met Tyr Leu Ala Phe Leu Gly Ala Ala Ile Ala Ile Gly Ala

360 365 370ccc ccg ttg atg gcg gcc ctg gtg ttg gcg tac acc tcc aat ttg ttc 1267Pro Pro Leu Met Ala Ala Leu Val Leu Ala Tyr Thr Ser Asn Leu Phe

375 380 385tct tca ctc act cag tat tct ggt ggt cct tcg cca aca ttg ttt ggt 1315Ser Ser Leu Thr Gln Tyr Ser Gly Gly Pro Ser Pro Thr Leu Phe Gly390 395 400 405ttg aac tac atc acg gtg ggt gag tgg tgg cgg acc tcg gca att gct 1363Leu Asn Tyr Ile Thr Val GlyGlu Trp Trp Arg Thr Ser Ala Ile Ala

410 415 420ggc gcg gta tcg att aca atc tgg ttg gtt atc ggt ggt ttg tgg atg 1411Gly Ala Val Ser Ile Thr Ile Trp Leu Val Ile Gly Gly Leu Trp Met

425 430 435aat gtc atc gga ctc tgg taatcgaaaa ttaaaggtaa ggg 1452Asn Val Ile Gly Leu Trp

440<210>532<211>443<212>PRT<2l3>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>532Met Phe Gly Leu Phe Ile Ala Thr Ile Val Ala Ile Ile Leu Lys Pro 151015 Met Pro Met Gly Ala Val Thr Ile Ile Gly Met Ile Ala Ala Val Leu

20 25 30Thr Gly Leu Val Pro Leu Thr Ala Ser Ser Asp Asp Pro Gly Ala Val

35 40 45Tyr Gly Leu Ile Gly Phe Ser Asn Gly Thr Ile Trp Leu Ile Val Met

50 55 60Ala Phe Leu Ile Ser Arg Gly Phe Ile Lys Thr Gly Leu Gly Arg Arg 65 70 75 80Ile Ala Leu Phe Phe Val Ser Lys Val Gly Gly Lys Met Leu Gly Val

85 90 95Thr Tyr Gly Leu Ala Leu Ala Asp Leu Val Leu Ala Pro Ala Ile Pro

100 105 110Ser Ala Thr Ala Arg Gly Gly Gly Ile Met Ala Pro Ile Met Lys Ser

115 120 125Val Ala Leu Thr Tyr Asp Ser Thr Pro Gly Pro Thr Arg Arg Arg Ala

130 135 140Gly Ala Phe Leu Ala Leu Asn Val Gly Gln Val Asn Ala Ile Thr Cys145 150 155 160Ala Met Phe Leu Thr Ala Met Ala Gly Asn Pro Leu Ile Ala Ser Leu

165 170 175Ala Ser Gln Met Asp Val Asn Ile Thr Trp Thr Asn Trp Ala Val Gly

180 185 190Ala Ile Val Pro Gly Leu Val Ala Leu Ile Val Val Pro Trp Val Val

195 200 205Tyr Lys Ile Tyr Pro Pro Glu Leu Lys Asp Thr Pro Glu Val Lys Lys

210 215 220Met Ala Ser Asp Glu Leu Lys Gln Leu Gly Gly Phe Thr Tyr Gly Glu225 230 235 240Lys Val Leu Ala Gly Thr Phe Val Val Leu Leu Leu Leu Trp Thr Gly

245 250 255Gly Asp Leu Val Leu Gly Ile Ser Ala Thr Thr Thr Ala Phe Val Gly

260 265 270Val Ile Ile Leu Leu Val Ala His Val Leu Thr Trp Glu Asp Ile Ile

275 280 285Gln Glu Lys Thr Ala Trp Asp Thr Met Val Trp Phe Ala Val Leu Tyr

290 295 300Met Met Ala Thr Ala Leu Ser Gln Tyr Gly Phe Ile Ala Trp Ile Ser305 310 315 320Glu Val Ile Ala Ser Ser Leu Gly Gly Met Asn Trp Val Val Ala Leu

325 330 335Val Val Leu Val Leu Ile Tyr Phe Phe Ser His Tyr Phe Phe Ala Ser

340 345 350Ala Thr Ala His Ile Ser Ala Met Tyr Leu Ala Phe Leu Gly Ala Ala

355 360 365Ile Ala Ile Gly Ala Pro Pro Leu Met Ala Ala Leu yal Leu Ala Tyr

370 375 380Thr Ser Asn LeuPhe Ser Ser Leu Thr Gln Tyr Ser Gly Gly Pro Ser385 390 395 400Pro Thr Leu Phe Gly Leu Asn Tyr Ile Thr Val Gly Glu Trp Trp Arg

405 410 415Thr Ser Ala Ile Ala Gly Ala Val Ser Ile Thr Ile Trp Leu Val Ile

420 425 430Gly Gly Leu Trp Met Asn Val Ile Gly Leu Trp

435440<210>533<211>1968<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1945)<223>RXN00298<400>533tttagacaag ttctggttaa aattcttcat gaaggtgaga atctgggaat ttctcggtac 60tctttcagat tcgtagttat ccactgattg gaagaatgag atg agc tca aat ata 115

Met Ser Ser Asn Ile

1 5gct atc acg acc gag cct gaa ggg aaa aat aaa aag ggt ctc aaa tca 163Ala Ile Thr Thr Glu Pro Glu Gly Lys Asn Lys Lys Gly Leu Lys Ser

10 15 20gac ccg ttc att ttt tcc att tct gtc ggt ttt atc gtg gtg ttt gtc 211Asp Pro Phe Ile Phe Ser Ile Ser Val Gly Phe Ile Val Val Phe Val

25 30 35atc gcc aca att gcg cta ggc gag aaa gct cga aca acc ttt tcc gcg 259Ile Ala Thr Ile Ala Leu Gly Glu Lys Ala Arg Thr Thr Phe Ser Ala

40 45 50att gcc ggc tgg ctc tta gaa aat tta ggg tgg atg tat atc ggg ggt 307Ile Ala Gly Trp Leu Leu Glu Asn Leu Gly Trp Met Tyr Ile Gly Gly

55 60 65gtc tcc ttg gtt ttc att ttc ctc atg ggt atc ttt gcg tcc cgg tat 355Val Ser Leu Val Phe Ile Phe Leu Met Gly Ile Phe Ala Ser Arg Tyr 70 75 80 85ggc cgg gta aaa ctt ggt gat gac gat gat gac ccc gag cac acc cta 403Gly Arg Val Lys Leu Gly Asp Asp Asp Asp Asp Pro Glu His Thr Leu

90 95 100atc gtg tgg ttc tgt atg ctt ttt gct ggc ggt gtc ggt gca gtc tta 451Ile Val Trp Phe Cys Met Leu Phe Ala Gly Gly Val Gly Ala Val Leu

105 110 115atg ttt tgg ggt gtt gcc gaa ccg att aac cac gcg ttc aac gtg cca 499Met Phe Trp Gly Val Ala Glu Pro Ile Asn His Ala Phe Asn Val Pro

120 125 130atg gct aat gaa gaa tcc atg agt gaa gcc gca att gtg cag gct ttt 547Met Ala Asn Glu Glu Ser Met Ser Glu Ala Ala Ile Val Gln Ala Phe

135 140 145gct tat act ttc tat cac ttc ggt att cac atg tgg gta atc atg gca 595Ala Tyr Thr Phe Tyr His Phe Gly Ile His Met Trp Val Ile Met Ala150 155 160 165ctc cca gga tta tca ttg gga tac ttt att tac aaa cgt aag cta cct 643Leu Pro Gly Leu Ser Leu Gly Tyr Phe Ile Tyr Lys Arg Lys Leu Pro

170 175 180ccc cgt cta tcc tct gtg ttt tct ccg atc ttg ggt aag cac att tat 691Pro Arg Leu Ser Ser Val Phe Ser Pro Ile Leu Gly Lys His Ile Tyr

185 190 195tcc aca ccc ggc aag ctc atc gat gta ctg gcc atc gta ggc acc acg 739Ser Thr Pro Gly Lys Leu Ile Asp Val Leu Ala Ile Val Gly Thr Thr

200 205 210ttt ggt att gct gtg tca gta ggt ctt ggt gtg ctg caa atc aat gca 787Phe Gly Ile Ala Val Ser Val Gly Leu Gly Val Leu Gln Ile Asn Ala

215 220 225ggt atg aac aaa cta tgg agc acc ccg caa gta tcg tgg gtt cag ctt 835Gly Met Asn Lys Leu Trp Ser Thr Pro Gln Val Ser Trp Val Gln Leu230 235 240 245ttg atc atc ttg atc atc acc gcg gtt gca tgt att tcc gtt gct tcc 883Leu Ile Ile Leu Ile Ile Thr Ala Val Ala Cys Ile Ser Val Ala Ser

250 255 260ggt ttg gat aag ggc att aag tta ctg tcc aac att aat att gca atg 931Gly Leu Asp Lys Gly Ile Lys Leu Leu Ser Asn Ile Asn Ile Ala Met

265 270 275gcc gtt gcg ttg atg ttc ttc atc ttg ttc act ggt cca acc ctc aca 979Ala Val Ala Leu Met Phe Phe Ile Leu Phe Thr Gly Pro Thr Leu Thr

280 285 290ttg ctg cgc ttt ctc gta gaa tcc ttc gga atc tat gca tcc tgg atg 1027Leu Leu Arg Phe Leu Val Glu Ser Phe Gly Ile Tyr Ala Ser Trp Met

295 300 305cct aat ctg atg ttt tgg act gac tct ttc caa gat aac cca ggc tgg 1075Pro Asn Leu Met Phe Trp Thr Asp Ser Phe Gln Asp Asn Pro Gly Trp310 315 320 325cag ggc aaa tgg acg gtg ttc tat tgg gca tgg act att tgt tgg tcg 1123Gln Gly Lys Trp Thr Val Phe Tyr Trp Ala Trp Thr Ile Cys Trp Ser

330 335 340cca tat gtc ggc atg ttc gtg gcg cgt att tcg cgt gga cgt acc gtc 1171Pro Tyr Val Gly Met Phe Val Ala Arg Ile Ser Arg Gly Arg Thr Val

345 350 355cgt gaa ttt atc ggt ggg gtt cta gct ctg cca gcg atc ttt ggc gta 1219Arg Glu Phe Ile Gly Gly Val Leu Ala Leu Pro Ala Ile Phe Gly Val

360 365 370gtt tgg ttc tct atc ttt ggt cgt gca ggc atc gaa gtg gaa ctg agt 1267Val Trp Phe Ser Ile Phe Gly Arg AlaGly Ile Glu Val Glu Leu Ser

375 380 385aac cca ggt ttc ttg acc cag cca act gtt gtt gaa ggt gac gtg cca 1315Asn Pro Gly Phe Leu Thr Gln Pro Thr Val Val Glu Gly Asp Val Pro390 395 400 405gca gcg ctt ttt aat gtg ctg caa gag tat ccg ctg act gga att gtc 1363Ala Ala Leu Phe Asn Val Leu Gln Glu Tyr Pro Leu Thr Gly Ile Val

410 415 420tcc gcg ttt gca ctt gta att att gtg att ttc ttt atc acc tcc atc 1411Ser Ala Phe Ala Leu Val Ile Ile Val Ile Phe Phe Ile Thr Ser Ile

425 430 435gat tcc gca gcg cta gtt aac gat atg ttc gct acc ggt gca gaa aat 1459Asp Ser Ala Ala Leu Val Asn Asp Met Phe Ala Thr Gly Ala Glu Asn

440 445 450caa aca ccg act agt tac cgc gtg atg tgg gcc tgc acc att ggg gcg 1507Gln Thr Pro Thr Ser Tyr Arg Val Met Trp Ala Cys Thr Ile Gly Ala

455 460 465gtc gca ggt tcc ttg ctg atc att tcc cca tcc tct ggt att gcc acg 1555Val Ala Gly Ser Leu Leu Ile Ile Ser Pro Ser Ser Gly Ile Ala Thr470 475 480 485ctg caa gaa gtg gtt atc atc gtg gct ttc cca ttc ttc ctc gtg caa 1603Leu Gln Glu Val Val Ile Ile Val Ala Phe Pro Phe Phe Leu Val Gln

490 495 500ttt gtc atg atg ttt tct ttg ctt aaa ggc atg agt gaa gat gct gct 1651Phe Val Met Met Phe Ser Leu Leu Lys Gly Met Ser Glu Asp Ala Ala

505 510 515gcg gtt cgt cgt gtg cag act cgt cag tgg gaa aag act gat aca cca 1699Ala Val Arg Arg Val Gln Thr Arg Gln Trp Glu Lys Thr Asp Thr Pro

520525 530gaa aaa ctt gaa gag cat tcg tcc caa cca gcc ccg ggc tat gat gac 1747Glu Lys Leu Glu Glu His Ser Ser Gln Pro Ala Pro Gly Tyr Asp Asp

535 540 545gag ggc aac ccc ttg cca atg cct gcc ctc gaa cat gat gag gac ggt 1795Glu Gly Asn Pro Leu Pro Met Pro Ala Leu Glu His Asp Glu Asp Gly550 555 560 565aac att gtt atc cca ggc aac gta gtc att gaa ggt gat ctt ggg gta 1843Asn Ile Val Ile Pro Gly Asn Val Val Ile Glu Gly Asp Leu Gly Val

570 575 580gtt ggt gat gtg gtc gac gat cct gag gaa gcc caa gag atg ggg tct 1891Val Gly Asp Val Val Asp Asp Pro Glu Glu Ala Gln Glu Met Gly Ser

585 590 595cgt ttt aag atc gtc gag caa act cgg ccc cag tcc agg gac gaa tac 1939Arg Phe Lys Ile yal Glu Gln Thr Arg Pro Gln Ser Arg Asp Glu Tyr

600 605 610gat att taaacgattg cttttcgacg cac 1968Asp Ile

615<210>534<211>615<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>534Met Ser Ser Asn Ile Ala Ile Thr Thr Glu Pro Glu Gly Lys Asn Lys 151015 Lys Gly Leu Lys Ser Asp Pro Phe Ile Phe Ser Ile Ser Val Gly Phe

20 25 30Ile Val Val Phe Val Ile Ala Thr Ile Ala Leu Gly Glu Lys Ala Arg

35 40 45Thr Thr Phe Ser Ala Ile Ala Gly Trp Leu Leu Glu Asn Leu Gly Trp

50 55 60Met Tyr Ile Gly Gly Val Ser Leu Val Phe Ile Phe Leu Met Gly Ile 65 70 75 80Phe Ala Ser Arg Tyr Gly Arg Val Lys LeuGly Asp Asp Asp Asp Asp

85 90 95Pro Glu His Thr Leu Ile Val Trp Phe Cys Met Leu Phe Ala Gly Gly

100 105 110Val Gly Ala Val Leu Met Phe Trp Gly Val Ala Glu Pro Ile Asn His

115 120 125Ala Phe Asn Val Pro Met Ala Asn Glu Glu Ser Met Ser Glu Ala Ala

130 135 140Ile Val Gln Ala Phe Ala Tyr Thr Phe Tyr His Phe Gly Ile His Met145 150 155 160Trp Val Ile Met Ala Leu Pro Gly Leu Ser Leu Gly Tyr Phe Ile Tyr

165 170 175Lys Arg Lys Leu Pro Pro Arg Leu Ser Ser Val Phe Ser Pro Ile Leu

180 185 190Gly Lys His Ile Tyr Ser Thr Pro Gly Lys Leu Ile Asp Val Leu Ala

195 200 205Ile Val Gly Thr Thr Phe Gly Ile Ala Val Ser Val Gly Leu Gly Val

210 215 220Leu Gln Ile Asn Ala Gly Met Asn Lys Leu Trp Ser Thr Pro Gln Val225 230 235 240Ser Trp Val Gln Leu Leu Ile Ile Leu Ile Ile Thr Ala Val Ala Cys

245 250 255Ile Ser Val Ala Ser Gly Leu Asp Lys Gly Ile Lys Leu Leu Ser Asn

260 265 270Ile Asn Ile Ala Met Ala Val Ala Leu Met Phe Phe Ile Leu Phe Thr

275 280 285Gly Pro Thr Leu Thr Leu Leu Arg Phe Leu Val Glu Ser Phe Gly Ile

290 295 300Tyr Ala Ser Trp Met Pro Asn Leu MetPhe Trp Thr Asp Ser Phe Gln305 310 315 320Asp Asn Pro Gly Trp Gln Gly Lys Trp Thr Val Phe Tyr Trp Ala Trp

325 330 335Thr Ile Cys Trp Ser Pro Tyr Val Gly Met Phe Val Ala Arg Ile Ser

340 345 350Arg Gly Arg Thr Val Arg Glu Phe Ile Gly Gly Val Leu Ala Leu Pro

355 360 365Ala Ile Phe Gly Val Val Trp Phe Ser Ile Phe Gly Arg Ala Gly Ile

370 375 380Glu Val Glu Leu Ser Asn Pro Gly Phe Leu Thr Gln Pro Thr Val Val385 390 395 400Glu Gly Asp Val Pro Ala Ala Leu Phe Asn Val Leu Gln Glu Tyr Pro

405 410 415Leu Thr Gly Ile Val Ser Ala Phe Ala Leu Val Ile Ile Val Ile Phe

420 425 430Phe Ile Thr Ser Ile Asp Ser Ala Ala Leu Val Asn Asp Met Phe Ala

435 440 445Thr Gly Ala Glu Asn Gln Thr Pro Thr Ser Tyr Arg Val Met Trp Ala

450 455 460Cys Thr Ile Gly Ala Val Ala Gly Ser Leu Leu Ile Ile Ser Pro Ser465 470 475 480Ser Gly Ile Ala Thr Leu Gln Glu Val Val Ile Ile Val Ala Phe Pro

485 490 495Phe Phe Leu Val Gln Phe Val Met Met Phe Ser Leu Leu Lys Gly Met

500 505 510Ser Glu Asp Ala Ala Ala Val Arg Arg Val Gln Thr Arg Gln Trp Glu

515 520 525Lys Thr Asp Thr Pro GluLys Leu Glu Glu His Ser Ser Gln Pro Ala

530 535 540Pro Gly Tyr Asp Asp Glu Gly Asn Pro Leu Pro Met Pro Ala Leu Glu545 550 555 560His Asp Glu Asp Gly Asn Ile Val Ile Pro Gly Asn Val Val Ile Glu

565 570 575Gly Asp Leu Gly Val Val Gly Asp Val Val Asp Asp Pro Glu Glu Ala

580 585 590Gln Glu Met Gly Ser Arg Phe Lys Ile Val Glu Gln Thr Arg Pro Gln

595 600 605Ser Arg Asp Glu Tyr Asp Ile

610615<210>535<211>1968<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1945)<223>FRXA00298<400>535tttagacaag ttctggttaa aattcttcat gaaggtgaga atctgggaat ttctcggtac 60tctttcagat tcgtagttat ccactgattg gaagaatgag atg agc tca aat ata 115

Met Ser Ser Asn Ile

1 5gct atc acg acc gag cct gaa ggg aaa aat aaa aag ggt ctc aaa tca 163Ala Ile Thr Thr Glu Pro Glu Gly Lys Asn Lys Lys Gly Leu Lys Ser

10 15 20gac ccg ttc att ttt tcc att tct gtc ggt ttt atc gtg gtg ttt gtc 211Asp Pro Phe Ile Phe Ser Ile Ser Val Gly Phe Ile Val Val Phe Val

25 30 35atc gcc aca att gcg cta ggc gag aaa gct cga aca acc ttt tcc gcg 259Ile Ala Thr Ile Ala Leu Gly Glu Lys Ala Arg Thr Thr Phe Ser Ala

40 45 50att gcc ggc tgg ctc tta gaa aat tta ggg tgg atgtat atc ggg ggt 307Ile Ala Gly Trp Leu Leu Glu Asn Leu Gly Trp Met Tyr Ile Gly Gly

55 60 65gtc tcc ttg gtt ttc att ttc ctc atg ggt atc ttt gcg tcc cgg tat 355Val Ser Leu Val Phe Ile Phe Leu Met Gly Ile Phe Ala Ser Arg Tyr 70 75 80 85ggc cgg gta aaa ctt ggt gat gac gat gat gac ccc gag cac acc cta 403Gly Arg Val Lys Leu Gly Asp Asp Asp Asp Asp Pro Glu His Thr Leu

90 95 100atc gtg tgg ttc tgt atg ctt ttt gct ggc ggt gtc ggt gca gtc tta 451Ile Val Trp Phe Cys Met Leu Phe Ala Gly Gly Val Gly Ala Val Leu

105 110 115atg ttt tgg ggt gtt gcc gaa ccg att aac cac gcg ttc aac gtg cca 499Met Phe Trp Gly Val Ala Glu Pro Ile Asn His Ala Phe Asn Val Pro

120 125 130atg gct aat gaa gaa tcc atg agt gaa gcc gca att gtg cag gct ttt 547Met Ala Asn Glu Glu Ser Met Ser Glu Ala Ala Ile Val Gln Ala Phe

135 140 145gct tat act ttc tat cac ttc ggt att cac atg tgg gta atc atg gca 595Ala Tyr Thr Phe Tyr His Phe Gly Ile His Met Trp Val Ile Met Ala150 155 160 165ctc cca gga tta tca ttg gga tac ttt att tac aaa cgt aag cta cct 643Leu Pro Gly Leu Ser Leu Gly Tyr Phe Ile Tyr Lys Arg Lys Leu Pro

170 175 180ccc cgt cta tcc tct gtg ttt tct ccg atc ttg ggt aag cac att tat 691Pro Arg Leu Ser Ser Val Phe Ser Pro Ile Leu Gly Lys His Ile Tyr

185 190 195tcc aca ccc ggc aag ctc atc gat gta ctg gcc atc gta ggc acc acg 739Ser Thr Pro Gly Lys Leu Ile Asp Val Leu Ala Ile Val Gly Thr Thr

200 205 210ttt ggt att gct gtg tca gta ggt ctt ggt gtg ctg caa atc aat gca 787Phe Gly Ile Ala Val Ser Val Gly Leu Gly Val Leu Gln Ile Asn Ala

215 220 225ggt atg aac aaa cta tgg agc acc ccg caa gta tcg tgg gtt cag ctt 835Gly Met Asn Lys Leu Trp Ser Thr Pro Gln Val Ser Trp Val Gln Leu230 235 240 245ttg atc atc ttg atc atc acc gcg gtt gca tgt att tcc gtt gct tcc 883Leu Ile Ile Leu Ile Ile Thr Ala Val Ala Cys Ile Ser Val Ala Ser

250 255 260ggt ttg gat aag ggc att aag tta ctg tcc aac att aat att gca atg 931Gly Leu Asp Lys Gly Ile Lys Leu Leu Ser Asn Ile Asn Ile Ala Met

265 270 275gcc gtt gcg ttg atg ttc ttc atc ttg ttc act ggt cca acc ctc aca 979Ala Val Ala Leu Met Phe Phe Ile Leu Phe Thr Gly Pro Thr Leu Thr

280 285 290ttg ctg cgc ttt ctc gta gaa tcc ttc gga atc tat gca tcc tgg atg 1027Leu Leu Arg Phe Leu Val Glu Ser Phe Gly Ile Tyr Ala Ser Trp Met

295 300 305cct aat ctg atg ttt tgg act gac tct ttc caa gat aac cca ggc tgg 1075Pro Asn Leu Met Phe Trp Thr Asp Ser Phe Gln Asp Asn Pro Gly Trp310 315 320 325cag ggc aaa tgg acg gtg ttc tat tgg gca tgg act att tgt tgg tcg 1123Gln Gly Lys Trp Thr Val Phe Tyr Trp Ala Trp Thr Ile Cys Trp Ser

330 335 340cca tat gtc ggc atg ttc gtg gcg cgt att tcg cgt gga cgt acc gtc 1171Pro Tyr Val Gly Met Phe Val Ala Arg Ile Ser Arg Gly Arg Thr Val

345 350 355cgt gaa ttt atc ggt ggg gtt cta gct ctg cca gcgatc ttt ggc gta 1219Arg Glu Phe Ile Gly Gly Val Leu Ala Leu Pro Ala Ile Phe Gly Val

360 365 370gtt tgg ttc tct atc ttt ggt cgt gca ggc atc gaa gtg gaa ctg agt 1267Val Trp Phe Ser Ile Phe Gly Arg Ala Gly Ile Glu Val Glu Leu Ser

375 380 385aac cca ggt ttc ttg acc cag cca act gtt gtt gaa ggt gac gtg cca 1315Asn Pro Gly Phe Leu Thr Gln Pro Thr Val Val Glu Gly Asp Val Pro390 395 400 405gca gcg ctt ttt aat gtg ctg caa gag tat ccg ctg act gga att gtc 1363Ala Ala Leu Phe Asn Val Leu Gln Glu Tyr Pro Leu Thr Gly Ile Val

410 415 420tcc gcg ttt gca ctt gta att att gtg att ttc ttt atc acc tcc atc 1411Ser Ala Phe Ala Leu Val Ile Ile Val Ile Phe Phe Ile Thr Ser Ile

425 430 435gat tcc gca gcg cta gtt aac gat atg ttc gct acc ggt gca gaa aat 1459Asp Ser Ala Ala Leu Val Asn Asp Met Phe Ala Thr Gly Ala Glu Asn

440 445 450caa aca ccg act agt tac cgc gtg atg tgg gcc tgc acc att ggg gcg 1507Gln Thr Pro Thr Ser Tyr Arg Val Met Trp Ala Cys Thr Ile Gly Ala

455 460 465gtc gca ggt tcc ttg ctg atc att tcc cca tcc tct ggt att gcc acg 1555Val Ala Gly Ser Leu Leu Ile Ile Ser Pro Ser Ser Gly Ile Ala Thr470 475 480 485ctg caa gaa gtg gtt atc atc gtg gct ttc cca ttc ttc ctc gtg caa 1603Leu Gln Glu Val Val Ile Ile Val Ala Phe Pro Phe Phe Leu Val Gln

490 495 500ttt gtc atg atg ttt tct ttg ctt aaa ggc atg agt gaa gat gct gct 1651Phe Val Met Met Phe Ser Leu Leu Lys Gly Met Ser Glu Asp Ala Ala

505 510 515gcg gtt cgt cgt gtg cag act cgt cag tgg gaa aag act gat aca cca 1699Ala Val Arg Arg Val Gln Thr Arg Gln Trp Glu Lys Thr Asp Thr Pro

520 525 530gaa aaa ctt gaa gag cat tcg tcc caa cca gcc ccg ggc tat gat gac 1747Glu Lys Leu Glu Glu His Ser Ser Gln Pro Ala Pro Gly Tyr Asp Asp

535 540 545gag ggc aac ccc ttg cca atg cct gcc ctc gaa cat gat gag gac ggt 1795Glu Gly Asn Pro Leu Pro Met Pro Ala Leu Glu His Asp Glu Asp Gly550 555 560 565aac att gtt atc cca ggc aac gta gtc att gaa ggt gat ctt ggg gta 1843Asn Ile Val Ile Pro Gly Asn Val Val Ile Glu Gly Asp Leu Gly Val

570 575 580gtt ggt gat gtg gtc gac gat cct gag gaa gcc caa gag atg ggg tct 1891Val Gly Asp Val Val Asp Asp Pro Glu Glu Ala Gln Glu Met Gly Ser

585 590 595cgt ttt aag atc gtc gag caa act cgg ccc cag tcc agg gac gaa tac 1939Arg Phe Lys Ile Val Glu Gln Thr Arg Pro Gln Ser Arg Asp Glu Tyr

600 605 610gat att taaacgattg cttttcgacg cac 1968Asp Ile

615<210>536<211>615<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>536Met Ser Ser Asn Ile Ala Ile Thr Thr Glu Pro Glu Gly Lys Asn Lys 151015 Lys Gly Leu Lys Ser Asp Pro Phe Ile Phe Ser Ile Ser Val Gly Phe

20 25 30Ile Val Val Phe Val Ile Ala Thr Ile Ala Leu Gly Glu Lys Ala Arg

35 40 45Thr Thr Phe Ser Ala Ile Ala GlyTrp Leu Leu Glu Asn Leu Gly Trp

50 55 60Met Tyr Ile Gly Gly Val Ser Leu Val Phe Ile Phe Leu Met Gly Ile 65 70 75 80Phe Ala Ser Arg Tyr Gly Arg Val Lys Leu Gly Asp Asp Asp Asp Asp

85 90 95Pro Glu His Thr Leu Ile Val Trp Phe Cys Met Leu Phe Ala Gly Gly

100 105 110Val Gly Ala Val Leu Met Phe Trp Gly Val Ala Glu Pro Ile Asn His

115 120 125Ala Phe Asn Val Pro Met Ala Asn Glu Glu Ser Met Ser Glu Ala Ala

130 135 140Ile Val Gln Ala Phe Ala Tyr Thr Phe Tyr His Phe Gly Ile His Met145 150 155 160Trp Val Ile Met Ala Leu Pro Gly Leu Ser Leu Gly Tyr Phe Ile Tyr

165 170 175Lys Arg Lys Leu Pro Pro Arg Leu Ser Ser Val Phe Ser Pro Ile Leu

180 185 190Gly Lys His Ile Tyr Ser Thr Pro Gly Lys Leu Ile Asp Val Leu Ala

195 200 205Ile Val Gly Thr Thr Phe Gly Ile Ala Val Ser Val Gly Leu Gly Val

210 215 220Leu Gln Ile Asn Ala Gly Met Asn Lys Leu Trp Ser Thr Pro Gln Val225 230 235 240Ser Trp Val Gln Leu Leu Ile Ile Leu Ile Ile Thr Ala Val Ala Cys

245 250 255Ile Ser Val Ala Ser Gly Leu Asp Lys Gly Ile Lys Leu Leu Ser Asn

260 265 270Ile Asn Ile Ala Met Ala Val Ala Leu Met Phe Phe Ile Leu Phe Thr

275 280 285Gly Pro Thr Leu Thr Leu Leu Arg Phe Leu Val Glu Ser Phe Gly Ile

290 295 300Tyr Ala Ser Trp Met Pro Asn Leu Met Phe Trp Thr Asp Ser Phe Gln305 310 315 320Asp Asn Pro Gly Trp Gln Gly Lys Trp Thr Val Phe Tyr Trp Ala Trp

325 330 335Thr Ile Cys Trp Ser Pro Tyr Val Gly Met Phe Val Ala Arg Ile Ser

340 345 350Arg Gly Arg Thr Val Arg Glu Phe Ile Gly Gly Val Leu Ala Leu Pro

355 360 365Ala Ile Phe Gly Val Val Trp Phe Ser Ile Phe Gly Arg Ala Gly Ile

370 375 380Glu Val Glu Leu Ser Asn Pro Gly Phe Leu Thr Gln Pro Thr Val Val385 390 395 400Glu Gly Asp Val Pro Ala Ala Leu Phe Asn Val Leu Gln Glu Tyr Pro

405 410 415Leu Thr Gly Ile Val Ser Ala Phe Ala Leu Val Ile Ile Val Ile Phe

420 425 430Phe Ile Thr Ser Ile Asp Ser Ala Ala Leu Val Asn Asp Met Phe Ala

435 440 445Thr Gly Ala Glu Asn Gln Thr Pro Thr Ser Tyr Arg Val Met Trp Ala

450 455 460Cys Thr Ile Gly Ala Val Ala Gly Ser Leu Leu Ile Ile Ser Pro Ser465 470 475 480Ser Gly Ile Ala Thr Leu Gln Glu Val Val Ile Ile Val Ala Phe Pro

485 490 495Phe Phe Leu Val Gln Phe Val Met Met Phe Ser LeuLeu Lys Gly Met

500 505 510Ser Glu Asp Ala Ala Ala Val Arg Arg Val Gln Thr Arg Gln Trp Glu

515 520 525Lys Thr Asp Thr Pro Glu Lys Leu Glu Glu His Ser Ser Gln Pro Ala

530 535 540Pro Gly Tyr Asp Asp Glu Gly Asn Pro Leu Pro Met Pro Ala Leu Glu545 550 555 560His Asp Glu Asp Gly Asn Ile Val Ile Pro Gly Asn Val Val Ile Glu

565 570 575Gly Asp Leu Gly Val Val Gly Asp Val Val Asp Asp Pro Glu Glu Ala

580 585 590Gln Glu Met Gly Ser Arg Phe Lys Ile Val Glu Gln Thr Arg Pro Gln

595 600 605Ser Arg Asp Glu Tyr Asp Ile

610615<210>537<211>576<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (553)<223>RXA00596<400>537ccgccaccga cggcctcttg aacaccgatg cataccaaca ggctgtgctc ggtgaaaatg 60ccatcggagt gccaagccct agctaccagg gaggaaacta atg ctt aac gcc ctg 115

Met Leu Asn Ala Leu

1 5aaa ttc atc cca tgg ctg atc ggc cag att ttc ctc tct ggc ttc agc 163Lys Phe Ile Pro Trp Leu Ile Gly Gln Ile Phe Leu Ser Gly Phe Ser

10 15 20gtg atc acc gct gcg gta aaa aag gac acc ggc ttc aac ccc gtt gtt 211Val Ile Thr Ala Ala Val Lys Lys Asp Thr Gly Phe Asn Pro Val Val

25 3035atc cgc tac cca ctt cga gtg acc acg gac ttc cag atc gca gcc ctg 259Ile Arg Tyr Pro Leu Arg Val Thr Thr Asp Phe Gln Ile Ala Ala Leu

40 45 50tca acg tgc atc acc gcg act cct tcc acc ctg tcc ctt ggc cta cgc 307Ser Thr Cys Ile Thr Ala Thr Pro Ser Thr Leu Ser Leu Gly Leu Arg

55 60 65gaa ccc cgc aag ccc ggc gac ccc acc att ttg ctg atc caa gca gtg 355Glu Pro Arg Lys Pro Gly Asp Pro Thr Ile Leu Leu Ile Gln Ala Val 70 75 80 85ttt ggt tcc gat cca gta gaa gtt ttt gaa tcc atc gcc gat atg gaa 403Phe Gly Ser Asp Pro Val Glu Val Phe Glu Ser Ile Ala Asp Met Glu

90 95 100caa cgc ctc gtc cct tcg gtc gct tca att gac cac ggc gtc cca ggc 451Gln Arg Leu Val Pro Ser Val Ala Ser Ile Asp His Gly Val Pro Gly

105 110 115caa ggc cct tac aag gag atc cgc ccc agc gat gct gag tgg cca agt 499Gln Gly Pro Tyr Lys Glu Ile Arg Pro Ser Asp Ala Glu Trp Pro Ser

120 125 130cgc gag atc gct gac acc gcc caa aac acc gtc agc caa gac aag agg 547Arg Glu Ile Ala Asp Thr Ala Gln Asn Thr Val Ser Gln Asp Lys Arg

135140145 gag ttt taaaacaaca tgactgcttt tgg 576Glu Phe150<210>538<211>151<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>538Met Leu Asn Ala Leu Lys Phe Ile Pro Trp Leu Ile Gly Gln Ile Phe 151015 Leu Ser Gly Phe Ser Val Ile Thr Ala Ala Val Lys Lys Asp Thr Gly

20 25 30Phe Asn Pro Val Val Ile Arg Tyr Pro Leu Arg Val Thr Thr Asp Phe

35 40 45Gln IleAla Ala Leu Ser Thr Cys Ile Thr Ala Thr Pro Ser Thr Leu

50 55 60Ser Leu Gly Leu Arg Glu Pro Arg Lys Pro Gly Asp Pro Thr Ile Leu 65 70 75 80Leu Ile Gln Ala Val Phe Gly Ser Asp Pro Val Glu Val Phe Glu Ser

85 90 95Ile Ala Asp Met Glu Gln Arg Leu Val Pro Ser Val Ala Ser Ile Asp

100 105 110His Gly Val Pro Gly Gln Gly Pro Tyr Lys Glu Ile Arg Pro Ser Asp

115 120 125Ala Glu Trp Pro Ser Arg Glu Ile Ala Asp Thr Ala Gln Asn Thr Val

130135140 Ser Gln Asp Lys Arg Glu Phe 145150<210>539<211>750<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101).)

Met Glu Pro Leu Phe

1 5caa agt ctt gcg gaa tcg gac aat att tct gtc att ggt gga ttt acc 163Gln Ser Leu Ala Glu Ser Asp Asn Ile Ser Val Ile Gly Gly Phe Thr

10 15 20caa ggc acc cga aat ctg tac acc act gat gcg ccg gtg aaa aga ccc 211Gln Gly Thr Arg Asn Leu Tyr Thr Thr Asp Ala Pro Val Lys Arg Pro

25 30 35gct gac ctg gct gga aag aag att cgc gtc cag gaa tcc gcc atg cac 259Ala Asp Leu Ala Gly Lys Lys Ile Arg Val Gln Glu Ser Ala Met His

40 45 50atc cgc atg att gaa ctc atg ggt ggc tcg gca acc ccg ttg act tac 307Ile Arg Met Ile Glu Leu Met Gly Gly Ser Ala Thr Pro Leu Thr Tyr

55 60 65ggc gag gta tat acc gcg atg cag tct ggt gtg ctg gat ggc gcg gaa 355Gly Glu Val Tyr Thr Ala Met Gln Ser Gly Val Leu Asp Gly Ala Glu 70 75 80 85aat aac gag atc agt tac gtt acc caa aac cac ttc gag gtt gct cgc 403Asn Asn Glu Ile Ser Tyr Val Thr Gln Asn His Phe Glu Val Ala Arg

90 95 100tac aac agc aac acc aat cac ctt gtc ggt ttg gat tac atg gtc atg 451Tyr Asn Ser Asn Thr Asn His Leu Val Gly Leu Asp Tyr Met Val Met

105 110 115cga cac gat ctg ctt gac gcc atg agc gag cca gac cgt gaa ttg ttc 499Arg His Asp Leu Leu Asp Ala Met Ser Glu Pro Asp Arg Glu Leu Phe

120 125 130ctg gaa gaa tgg gac gcc gcg atg act gag cac acg gat ctg tgg aac 547Leu Glu Glu Trp Asp Ala Ala Met Thr Glu His Thr Asp Leu Trp Asn

135 140 145aca gaa act gat gcc gtt att gaa aag gcg aaa gct ggg gga gcg gag 595Thr Glu Thr Asp Ala Val Ile Glu Lys Ala Lys Ala Gly Gly Ala Glu150 155 160 165ttc gtt gag gtg gat gcg caa gca ttt acc gat gca ctg gct ccc atc 643Phe Val Glu Val Asp Ala Gln Ala Phe Thr Asp Ala Leu Ala Pro Ile

170 175 180aaa gac gaa ttc ttg acc tca gaa ttc cag cgt gaa ctc tac gaa gca 691Lys Asp Glu Phe Leu Thr Ser Glu Phe Gln Arg Glu Leu Tyr Glu Ala

185 190 195gtg cgc gcc gct gat act tca gga ggt gcg gca tca tgatgaattt 737Val Arg Ala Ala Asp Thr Ser Gly Gly Ala Ala Ser

200205 taagtccatc gtg 750<210>540<211>209<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>540Met Glu Pro Leu Phe Gln Ser Leu Ala Glu Ser Asp Asn Ile Ser Val 151015 Ile Gly Gly Phe Thr Gln Gly Thr Arg Asn Leu Tyr Thr Thr Asp Ala

20 25 30Pro Val Lys Arg Pro Ala Asp Leu Ala Gly Lys Lys Ile Arg Val Gln

35 40 45Glu Ser Ala Met His Ile Arg Met Ile Glu Leu Met Gly Gly Ser Ala

50 55 60Thr Pro Leu Thr Tyr Gly Glu Val Tyr Thr Ala Met Gln Ser Gly Val 65 70 75 80Leu Asp Gly Ala Glu Asn Asn Glu Ile Ser Tyr Val Thr Gln Asn His

85 90 95Phe Glu Val Ala Arg Tyr Asn Ser Asn Thr Asn His Leu Val Gly Leu

100 105 110Asp Tyr Met Val Met Arg His Asp Leu Leu Asp Ala Met Ser Glu Pro

115 120 125Asp Arg Glu Leu Phe Leu Glu Glu Trp Asp Ala Ala Met Thr Glu His

130 135 140Thr Asp Leu Trp Asn Thr Glu Thr Asp Ala Val Ile Glu Lys Ala Lys145 150 155 160Ala Gly Gly Ala Glu Phe Val Glu Val Asp Ala Gln Ala Phe Thr Asp

165 170 175Ala Leu Ala Pro Ile Lys Asp Glu Phe Leu Thr Ser Glu Phe Gln Arg

180 185 190Glu Leu Tyr Glu Ala Val Arg Ala Ala Asp Thr Ser Gly Gly Ala Ala

195200205 Ser<210>541<211>888<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (865)<223>RXN01411<400>541cttatcgacg tccccatccc cctcgccaat gcttcggcga ggggttctat ttattgtgtg 60tgctagcctt ttcgcaatcg ttcagcccgc cccgacgtca atg ttg gga gtg ggc 115

Met Leu Gly Val Gly

1 5tgg cgc att cca ttc ctg atg gcc gtg cca cta ggg ctt atc ggc tgg 163Trp Arg Ile Pro Phe Leu Met Ala Val Pro Leu Gly Leu Ile Gly Trp

10 15 20tgg atc cgc acc ggt gcc cag gaa aat gta cgc ccc gca tcc gaa cgc 211Trp Ile Arg Thr Gly Ala Gln Glu Asn Val Arg Pro Ala Ser Glu Arg

25 30 35ccc gaa gct cct att aag cag gca ttg cgt act gag tgg aag atg atg 259Pro Glu Ala Pro Ile Lys Gln Ala Leu Arg Thr Glu Trp Lys Met Met

40 45 50ttg cgg gta ggt ggc ttt atc tct tgc acc ggt ctg agc ttc tac att 307Leu Arg Val Gly Gly Phe Ile Ser Cys Thr Gly Leu Ser Phe Tyr Ile

55 60 65ttc acc acg tac atg acc act ttc ctg cgc agc acc gtc gga ctg gag 355Phe Thr Thr Tyr Met Thr Thr Phe Leu Arg Ser Thr Val Gly Leu Glu 70 75 80 85ggc acg tta gtg ctg gct gga aac atc atc gct ctc agc atg gca gca 403Gly Thr Leu Val Leu Ala Gly Asn Ile Ile Ala Leu Ser Met Ala Ala

90 95 100att gtg gcc cca ttt gtt ggc cgc gca att gat aaa ttc ccc cgc cgg 451Ile Val Ala Pro Phe Val Gly Arg Ala Ile Asp Lys Phe Pro Arg Arg

105 110 115aac atc atg gct ttc gct acc tta agc aca gta att atg gcg atc ccg 499Asn Ile Met Ala Phe Ala Thr Leu Ser Thr Val Ile Met Ala Ile Pro

120125 130gcc tac atc att gca ggt caa ggt act ttg act gct tct ttg att gcg 547Ala Tyr Ile Ile Ala Gly Gln Gly Thr Leu Thr Ala Ser Leu Ile Ala

135 140 145cag gta atg ctt gga atc ggc gcg gtt acc gct aac tgc gtt acc tca 595Gln Val Met Leu Gly Ile Gly Ala Val Thr Ala Asn Cys Val Thr Ser150 155 160 165gta atg atg gcc gag gtc ttc caa gag gtc acc cgc ggt act tcc gcc 643Val Met Met Ala Glu Val Phe Gln Glu Val Thr Arg Gly Thr Ser Ala

170 175 180ggc att acc tac aac gtc act tac gca atc ttc ggc ggc tcg gct cca 691Gly Ile Thr Tyr Asn Val Thr Tyr Ala Ile Phe Gly Gly Ser Ala Pro

185 190 195ttt atc tcc acc gca ttg gtc tcc tgg acc ggc agc ccg ctg gcc cct 739Phe Ile Ser Thr Ala Leu Val Ser Trp Thr Gly Ser Pro Leu Ala Pro

200 205 210gcg gta tac atg atc atc att gcg ctc ttc gcc ttc acc gcg tcc cgc 787Ala Val Tyr Met Ile Ile Ile Ala Leu Phe Ala Phe Thr Ala Ser Arg

215 220 225ttc att cct gaa acc tcc cca gtt ttt gtc acc gca acc ccg gcc att 835Phe Ile Pro Glu Thr Ser Pro Val Phe Val Thr Ala Thr Pro Ala Ile230 235 240 245aag gca cca aag gtg ctg gtc aac ccg ggt taaaccacgc ttttcgacga 885Lys Ala Pro Lys Val Leu Val Asn Pro Gly

250255 aaa 888<210>542<211>255<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>542Met Leu Gly Val Gly Trp Arg Ile Pro Phe Leu Met Ala Val Pro Leu 151015 Gly Leu Ile Gly Trp Trp Ile Arg Thr Gly Ala Gln Glu Asn Val Arg

20 25 30Pro Ala Ser Glu Arg Pro Glu Ala Pro Ile Lys Gln Ala Leu Arg Thr

35 40 45Glu Trp Lys Met Met Leu Arg Val Gly Gly Phe Ile Ser Cys Thr Gly

50 55 60Leu Ser Phe Tyr Ile Phe Thr Thr Tyr Met Thr Thr Phe Leu Arg Ser 65 70 75 80Thr Val Gly Leu Glu Gly Thr Leu Val Leu Ala Gly Asn Ile Ile Ala

85 90 95Leu Ser Met Ala Ala Ile Val Ala Pro Phe Val Gly Arg Ala Ile Asp

100 105 110Lys Phe Pro Arg Arg Asn Ile Met Ala Phe Ala Thr Leu Ser Thr Val

115 120 125Ile Met Ala Ile Pro Ala Tyr Ile Ile Ala Gly Gln Gly Thr Leu Thr

130 135 140Ala Ser Leu Ile Ala Gln Val Met Leu Gly Ile Gly Ala Val Thr Ala145 150 155 160Asn Cys Val Thr Ser Val Met Met Ala Glu Val Phe Gln Glu Val Thr

165 170 175Arg Gly Thr Ser Ala Gly Ile Thr Tyr Asn Val Thr Tyr Ala Ile Phe

180 185 190Gly Gly Ser Ala Pro Phe Ile Ser Thr Ala Leu Val Ser Trp Thr Gly

195 200 205Ser Pro Leu Ala Pro Ala Val Tyr Met Ile Ile Ile Ala Leu Phe Ala

210 215 220Phe Thr Ala Ser Arg Phe Ile Pro Glu Thr Ser Pro Val Phe Val Thr225 230 235 240Ala Thr Pro Ala Ile Lys Ala Pro Lys Val Leu Val Asn Pro Gly

245250255<210>543<211>1058<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1).<1035><223>RXN00960<400>543atg gct cgg cat tgt tgc agc aat cgc tac gcg tcc acc gtc ttc tcc 48Met Ala Arg His Cys Cys Ser Asn Arg Tyr Ala Ser Thr Val Phe Ser 151015 ggt ctg atc gcc tac gga gca tcc caa gcg ctc tac cca tgg ctg ctg 96Gly Leu Ile Ala Tyr Gly Ala Ser Gln Ala Leu Tyr Pro Trp Leu Leu

20 25 30aaa gac cac caa agc gtc acc gaa atc gac ctt gat gca ggt gcc ctc 144Lys Asp His Gln Ser Val Thr Glu Ile Asp Leu Asp Ala Gly Ala Leu

35 40 45cag ccc tac ttc aac atc gag atg cca cca cca ttt gaa gtg atg acc 192Gln Pro Tyr Phe Asn Ile Glu Met Pro Pro Pro Phe Glu Val Met Thr

50 55 60gca ctg ctg ctg gca ttc tgc ctc ggc ctg ggc atg gct gta att aaa 240Ala Leu Leu Leu Ala Phe Cys Leu Gly Leu Gly Met Ala Val Ile Lys 65 70 75 80tca gac acc ctg ttc aag gta acc cgc gaa ctc gag cgc gta gtc atg 288Ser Asp Thr Leu Phe Lys Val Thr Arg Glu Leu Glu Arg Val Val Met

85 90 95aag acc atc acc gcc ttt gtc atc cca ctg ctg cca ctc ttc atc ttc 336Lys Thr Ile Thr Ala Phe Val Ile Pro Leu Leu Pro Leu Phe Ile Phe

100 105 110ggc atc ttc ctc ggc atg ggc atg aac ggt ggc ctc ctg gag atc atg 384Gly Ile Phe Leu Gly Met Gly Met Asn Gly Gly Leu Leu Glu Ile Met

115 120 125tcc gcc ttt ggc aag gta ctg att ctc gcc gtc gtg gga acc ctg ctc 432Ser Ala Phe Gly Lys Val Leu Ile Leu Ala Val Val Gly Thr Leu Leu

130 135140ttc cta gcc atc cag ttc att atc gct ggt gca gta tcc aag aag aac 480Phe Leu Ala Ile Gln Phe Ile Ile Ala Gly Ala Val Ser Lys Lys Asn145 150 155 160cca tgg aaa ctg ttc aaa aac atg ctc cct gca tac ttc act gca ctg 528Pro Trp Lys Leu Phe Lys Asn Met Leu Pro Ala Tyr Phe Thr Ala Leu

165 170 175ggc act tcc tct tca gcg gca acc atc cca gtg acc tac cag cag acc 576Gly Thr Ser Ser Ser Ala Ala Thr Ile Pro Val Thr Tyr Gln Gln Thr

180 185 190ctg aaa aac gat gtt gat gtc aac gtc gca ggc ttt gtt gtc cca ctg 624Leu Lys Asn Asp Val Asp Val Asn Val Ala Gly Phe Val Val Pro Leu

195 200 205tgc gcc acc atc cac cta gct gga tcg atg atg aag atc ggc ctc ttc 672Cys Ala Thr Ile His Leu Ala Gly Ser Met Met Lys Ile Gly Leu Phe

210 215 220acc ttc gct gtt gtc ttc atg tac gac atg gaa gta ggc gtc ggc ctc 720Thr Phe Ala Val Val Phe Met Tyr Asp Met Glu Val Gly Val Gly Leu225 230 235 240tcc atc gga ttc ctc ctc atg ctg ggc atc acc atg atc gcc gca cca 768Ser Ile Gly Phe Leu Leu Met Leu Gly Ile Thr Met Ile Ala Ala Pro

245 250 255ggc gtt ccc ggc gga gcc atc atg gca gca acc ggc atg ctg gcc tcc 816Gly Val Pro Gly Gly Ala Ile Met Ala Ala Thr Gly Met Leu Ala Ser

260 265 270atg ctc gga ttc aac acc gaa caa gtc gcc ctc atg atc gcc gct tac 864Met Leu Gly Phe Asn Thr Glu Gln Val Ala Leu Met Ile Ala Ala Tyr

275 280 285atc gcg att gac tcc ttc ggc acc gca gca aac gtc acc ggc gac ggc 912Ile Ala Ile Asp Ser Phe Gly Thr Ala Ala Asn ValThr Gly Asp Gly

290 295 300gca atc gca gtc atc gtg aac aaa ttc gcc aag ggc cag ctg cac acc 960Ala Ile Ala Val Ile Val Asn Lys Phe Ala Lys Gly Gln Leu His Thr305 310 315 320act tcc cca gat gaa atc gaa gaa gac gac cgc gtt gcc ttc gac atc 1008Thr Ser Pro Asp Glu Ile Glu Glu Asp Asp Arg Val Ala Phe Asp Ile

325 330 335act cca tcg gat gtg gaa cat cac aag tagaaacccg cattttctgt 1055Thr Pro Ser Asp Val Glu His His Lys

340345 agt1058<210>544<211>345<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>544Met Ala Arg His Cys Cys Ser Asn Arg Tyr Ala Ser Thr Val Phe Ser 151015 Gly Leu Ile Ala Tyr Gly Ala Ser Gln Ala Leu Tyr Pro Trp Leu Leu

20 25 30Lys Asp His Gln Ser Val Thr Glu Ile Asp Leu Asp Ala Gly Ala Leu

35 40 45Gln Pro Tyr Phe Asn Ile Glu Met Pro Pro Pro Phe Glu Val Met Thr

50 55 60Ala Leu Leu Leu Ala Phe Cys Leu Gly Leu Gly Met Ala Val Ile Lys 65 70 75 80Ser Asp Thr Leu Phe Lys Val Thr Arg Glu Leu Glu Arg Val Val Met

85 90 95Lys Thr Ile Thr Ala Phe Val Ile Pro Leu Leu Pro Leu Phe Ile Phe

100 105 110Gly Ile Phe Leu Gly Met Gly Met Asn Gly Gly Leu Leu Glu Ile Met

115 120 125Ser Ala Phe Gly Lys Val Leu Ile Leu Ala Val Val Gly Thr Leu Leu

130 135140Phe Leu Ala Ile Gln Phe Ile Ile Ala Gly Ala Val Ser Lys Lys Asn145 150 155 160Pro Trp Lys Leu Phe Lys Asn Met Leu Pro Ala Tyr Phe Thr Ala Leu

165 170 175Gly Thr Ser Ser Ser Ala Ala Thr Ile Pro Val Thr Tyr Gln Gln Thr

180 185 190Leu Lys Asn Asp Val Asp Val Asn Val Ala Gly Phe Val Val Pro Leu

195 200 205Cys Ala Thr Ile His Leu Ala Gly Ser Met Met Lys Ile Gly Leu Phe

210 215 220Thr Phe Ala Val Val Phe Met Tyr Asp Met Glu Val Gly Val Gly Leu225 230 235 240Ser Ile Gly Phe Leu Leu Met Leu Gly Ile Thr Met Ile Ala Ala Pro

245 250 255Gly Val Pro Gly Gly Ala Ile Met Ala Ala Thr Gly Met Leu Ala Ser

260 265 270Met Leu Gly Phe Asn Thr Glu Gln Val Ala Leu Met Ile Ala Ala Tyr

275 280 285Ile Ala Ile Asp Ser Phe Gly Thr Ala Ala Asn Val Thr Gly Asp Gly

290 295 300Ala Ile Ala Val Ile Val Asn Lys Phe Ala Lys Gly Gln Leu His Thr305 310 315 320Thr Ser Pro Asp Glu Ile Glu Glu Asp Asp Arg Val Ala Phe Asp Ile

325 330 335Thr Pro Ser Asp Val Glu His His Lys

340345<210>545<211>1118<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (1095)<223>RXN02447<400>545aca gta gtt ccg gtg tac ctc gct gaa ctc gca cca cta gaa atc cgc 48Thr Val Val Pro Val Tyr Leu Ala Glu Leu Ala Pro Leu Glu Ile Arg 151015 ggc tcc ctg acc ggc cga aac gag ctt gct atc gtc acc ggc cag ctg 96Gly Ser Leu Thr Gly Arg Asn Glu Leu Ala Ile Val Thr Gly Gln Leu

20 25 30ctt gcc ttc gtg atc aac gcg ctt atc gcc gtc acc cta cac gga gtt 144Leu Ala Phe Val Ile Asn Ala Leu Ile Ala Val Thr Leu His Gly Val

35 40 45att gat gga atc tgg cgc atc atg ttc gcc gtc tgt gcc ctc cct gcc 192Ile Asp Gly Ile Trp Arg Ile Met Phe Ala Val Cys Ala Leu Pro Ala

50 55 60gtc gcc ctc ttc ctc ggc atg ctg cgg atg ccg gaa tca cca cgc tgg 240Val Ala Leu Phe Leu Gly Met Leu Arg Met Pro Glu Ser Pro Arg Trp 65 70 75 80ctg gtc aac cag ggg cgt tac gac gac gcc cgc cgc gtc atg gag acc 288Leu Val Asn Gln Gly Arg Tyr Asp Asp Ala Arg Arg Val Met Glu Thr

85 90 95gtc cgt acc cct gag cgt gcg aaa gcc gaa atg gat gaa atc atc gcg 336Val Arg Thr Pro Glu Arg Ala Lys Ala Glu Met Asp Glu Ile Ile Ala

100 105 110gtg cac tct gaa aac aat gcg gca ctt cct ggt gtt aag cag tct tcg 384Val His Ser Glu Asn Asn Ala Ala Leu Pro Gly Val Lys Gln Ser Ser

115 120 125ggc cag gct tca ggc cag gtt tct agc aag cac acc cac atg tcc atc 432Gly Gln Ala Ser Gly Gln Val Ser Ser Lys His Thr His Met Ser Ile

130 135 140ggc gaa gtc ctc agc aac aaa tgg ctg gtt cgt ctg ctc atc gcc ggc 480Gly Glu Val Leu Ser Asn Lys Trp Leu Val Arg Leu Leu Ile Ala Gly145 150155 160atc ggt gtt gca gtt gcc cag cag ctc acc ggc atc aac gcc atc atg 528Ile Gly Val Ala Val Ala Gln Gln Leu Thr Gly Ile Asn Ala Ile Met

165 170 175tac tac gga acc cgc gtc ctc gag gaa tcc ggc atg agc gca gaa atg 576Tyr Tyr Gly Thr Arg Val Leu Glu Glu Ser Gly Met Ser Ala Glu Met

180 185 190gct gtg gtt gcc aac att gct ttc ggt gcc gtt gcc gtc atc ggt gga 624Ala Val Val Ala Asn Ile Ala Phe Gly Ala Val Ala Val Ile Gly Gly

195 200 205ctg atc gca ctg cgc aac atg gac cgc ctg gat cgc cgc acc acc ttc 672Leu Ile Ala Leu Arg Asn Met Asp Arg Leu Asp Arg Arg Thr Thr Phe

210 215 220atc atc ggc ctg tca ctg acc acc acc ttc cac ctt ttg atc gca gct 720Ile Ile Gly Leu Ser Leu Thr Thr Thr Phe His Leu Leu Ile Ala Ala225 230 235 240gcc ggc act ctc ctt cca gaa ggt aac tcc att cga cca ttc gcc atc 768Ala Gly Thr Leu Leu Pro Glu Gly Asn Ser Ile Arg Pro Phe Ala Ile

245 250 255atg atc ctt gtt gtt ggg ttc gtg ctc tcc atg cag act ttc ctc aac 816Met Ile Leu Val Val Gly Phe Val Leu Ser Met Gln Thr Phe Leu Asn

260 265 270gtt gca gtg tgg gtg tgg ctg gcg gaa atc ttc cca gtc cga atg aag 864Val Ala Val Trp Val Trp Leu Ala Glu Ile Phe Pro Val Arg Met Lys

275 280 285ggt atc ggc acc ggt att tcg gta ttc tgc ggt tgg ggc atc aat ggc 912Gly Ile Gly Thr Gly Ile Ser Val Phe Cys Gly Trp Gly Ile Asn Gly

290 295 300gtc cta gcg ttg ttc ttc cca gca ctg gtc tcc ggc gtg ggt atc acc960Val Leu Ala Leu Phe Phe Pro Ala Leu Val Ser Gly Val Gly Ile Thr305 310 315 320ttc tcc ttc ctt atc ttc gca gtc gtc gga gtc att gcc ctg gcg ttc 1008Phe Ser Phe Leu Ile Phe Ala Val Val Gly Val Ile Ala Leu Ala Phe

325 330 335gtc acc aag ttt gtt cct gaa acc cgt ggc cgc tca ctt gaa gaa ctc 1056Val Thr Lys Phe Val Pro Glu Thr Arg Gly Arg Ser Leu Glu Glu Leu

340 345 350gat cac gca gca ttc acc ggc cag atc ttc aag aag gct taaaccccct 1105Asp His Ala Ala Phe Thr Gly Gln Ile Phe Lys Lys Ala

355360365 ccgatctctt tgg 1118<210>546<211>365<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>546Thr Val Val Pro Val Tyr Leu Ala Glu Leu Ala Pro Leu Glu Ile Arg 151015 Gly Ser Leu Thr Gly Arg Asn Glu Leu Ala Ile Val Thr Gly Gln Leu

20 25 30Leu Ala Phe Val Ile Asn Ala Leu Ile Ala Val Thr Leu His Gly Val

35 40 45Ile Asp Gly Ile Trp Arg Ile Met Phe Ala Val Cys Ala Leu Pro Ala

50 55 60Val Ala Leu Phe Leu Gly Met Leu Arg Met Pro Glu Ser Pro Arg Trp 65 70 75 80Leu Val Asn Gln Gly Arg Tyr Asp Asp Ala Arg Arg Val Met Glu Thr

85 90 95Val Arg Thr Pro Glu Arg Ala Lys Ala Glu Met Asp Glu Ile Ile Ala

100 105 110Val His Ser Glu Asn Asn Ala Ala Leu Pro Gly Val Lys Gln Ser Ser

115 120 125Gly Gln Ala Ser Gly Gln Val SerSer Lys His Thr His Met Ser Ile

130 135 140Gly Glu Val Leu Ser Asn Lys Trp Leu Val Arg Leu Leu Ile Ala Gly145 150 155 160Ile Gly Val Ala Val Ala Gln Gln Leu Thr Gly Ile Asn Ala Ile Met

165 170 175Tyr Tyr Gly Thr Arg Val Leu Glu Glu Ser Gly Met Ser Ala Glu Met

180 185 190Ala Val Val Ala Asn Ile Ala Phe Gly Ala Val Ala Val Ile Gly Gly

195 200 205Leu Ile Ala Leu Arg Asn Met Asp Arg Leu Asp Arg Arg Thr Thr Phe

210 215 220Ile Ile Gly Leu Ser Leu Thr Thr Thr Phe His Leu Leu Ile Ala Ala225 230 235 240Ala Gly Thr Leu Leu Pro Glu Gly Asn Ser Ile Arg Pro Phe Ala Ile

245 250 255Met Ile Leu Val Val Gly Phe Val Leu Ser Met Gln Thr Phe Leu Asn

260 265 270Val Ala Val Trp Val Trp Leu Ala Glu Ile Phe Pro Val Arg Met Lys

275 280 285Gly Ile Gly Thr Gly Ile Ser Val Phe Cys Gly Trp Gly Ile Asn Gly

290 295 300Val Leu Ala Leu Phe Phe Pro A1a Leu Val Ser Gly Val Gly Ile Thr305 310 315 320Phe Ser Phe Leu Ile Phe Ala Val Val Gly Val Ile Ala Leu Ala Phe

325 330 335Val Thr Lys Phe Val Pro Glu Thr Arg Gly Arg Ser Leu Glu Glu Leu

340 345 350Asp His Ala AlaPhe Thr Gly Gln Ile Phe Lys Lys Ala

355360365<210>547<211>2013<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<1990>RXN02395<400>547aaacaggaat atttaactcg acttcttaaa aaagctctat acgtaaatat cttgcccatc 60cagcaccacc tcattgtggt gcacaatgga gaggacacac atg tcc acc aac tct 115

Met Ser Thr Asn Ser

1 5ggc aat aac ttg cct gaa tcc caa gag tca ccc gag gaa cct cat tat 163Gly Asn Asn Leu Pro Glu Ser Gln Glu Ser Pro Glu Glu Pro His Tyr

10 15 20cct cac gac acc cac cca ggc cta gtt cct ggc att tcg gtc gat gct 211Pro His Asp Thr His Pro Gly Leu Val Pro Gly Ile Ser Val Asp Ala

25 30 35caa cgc aac aag ttc gga ctc gac aaa acc gtt ttc ggc gtc acc gca 259Gln Arg Asn Lys Phe Gly Leu Asp Lys Thr Val Phe Gly Val Thr Ala

40 45 50gca tta att ctg gcg ttc atc gcc tgg ggc att tcc agc cct gat tcg 307Ala Leu Ile Leu Ala Phe Ile Ala Trp Gly Ile Ser Ser Pro Asp Ser

55 60 65gtt tct tca gta tcg tcc acg atg ttc agt tgg gct atg acg aat act 355Val Ser Ser Val Ser Ser Thr Met Phe Ser Trp Ala Met Thr Asn Thr 70 75 80 85ggt tgg ctc ctc aac ttt gtc atg ctg atc ggc att ggc acc atg ctc 403Gly Trp Leu Leu Asn Phe Val Met Leu Ile Gly Ile Gly Thr Met Leu

90 95 100tac atc gct ttt tcg cgc tac ggc cgc atc aag ctg ggc acg gac gaa 451Tyr Ile Ala Phe Ser Arg Tyr Gly Arg Ile Lys Leu Gly Thr Asp Glu

105 110 115gac gaa cca gaa ttc tct cgc ttt tcc tgg att gcg atg atg ttc ggc 499Asp Glu Pro Glu Phe Ser Arg Phe Ser Trp Ile Ala Met Met Phe Gly

120 125 130gcc ggc atc ggt gtc ggt atc ttc ttc ttc ggt cct tcc gaa ccg ctg 547Ala Gly Ile Gly Val Gly Ile Phe Phe Phe Gly Pro Ser Glu Pro Leu

135 140 145tgg cat tat ctc agt ccc cca cct cac acc gtg gaa gga tct aca cct 595Trp His Tyr Leu Ser Pro Pro Pro His Thr Val Glu Gly Ser Thr Pro150 155 160 165gag tcc ttg cac caa gca ctt gcg cag tcc cac ttc cac tgg ggc tta 643Glu Ser Leu His Gln Ala Leu Ala Gln Ser His Phe His Trp Gly Leu

170 175 180tcc gcc tgg ggg ctg tat gcc ttg gtc ggc ggc gcg ttg gcg tac tcc 691Ser Ala Trp Gly Leu Tyr Ala Leu Val Gly Gly Ala Leu Ala Tyr Ser

185 190 195agt tac cga cgc ggc cgc gta acc ttg atc agc tcc acc ttc cgg tca 739Ser Tyr Arg Arg Gly Arg Val Thr Leu Ile Ser Ser Thr Phe Arg Ser

200 205 210ctt ttc ggt gag aaa acc gaa ggt atc gcg ggt cgc ctc atc gac atg 787Leu Phe Gly Glu Lys Thr Glu Gly Ile Ala Gly Arg Leu Ile Asp Met

215 220 225atg gcg atc atc gcc acg ctg ttt gga acg gct gca acc ttg ggc ctt 835Met Ala Ile Ile Ala Thr Leu Phe Gly Thr Ala Ala Thr Leu Gly Leu230 235 240 245tca gca att cag gtt ggt cag ggc gtg cag att att tct ggc gct tcg 883Ser Ala Ile Gln Val Gly Gln Gly Val Gln Ile Ile Ser Gly Ala Ser

250 255 260gaa atc acc aac aac atc ttg atc gcc atc atc gcg atc ttg acc att 931Glu Ile Thr Asn Asn Ile Leu Ile Ala Ile Ile Ala Ile Leu Thr Ile

265 270 275ggc ttc atc atc tcc tca gta tct ggc gtg tcc aag ggc att cgt tat 979Gly Phe Ile Ile Ser Ser Val Ser Gly Val Ser Lys Gly Ile Arg Tyr

280 285 290ctt tcc aac ctc aat att tcc ttg acg ctt gga ttg gtc ctg ttt gtg 1027Leu Ser Asn Leu Asn Ile Ser Leu Thr Leu Gly Leu Val Leu Phe Val

295 300 305ttc atc acc ggc ccc acc ttg ttc ctg ctc aac ttg atc cca tcg agt 1075Phe Ile Thr Gly Pro Thr Leu Phe Leu Leu Asn Leu Ile Pro Ser Ser310 315 320 325gtg ttg gaa tat ggc agt gag ttc ttg tca atg gct ggc aag tct ttg 1123Val Leu Glu Tyr Gly Ser Glu Phe Leu Ser Met Ala Gly Lys Ser Leu

330 335 340tcg tgg ggt gag gaa acc att gaa ttc caa gct ggt tgg acg gcg ttc 1171Ser Trp Gly Glu Glu Thr Ile Glu Phe Gln Ala Gly Trp Thr Ala Phe

345 350 355tac tgg gca tgg tgg atc gca tgg act cca ttc gtg ggt atg ttc atc 1219Tyr Trp Ala Trp Trp Ile Ala Trp Thr Pro Phe Val Gly Met Phe Ile

360 365 370gcg cgt att tct cgc ggc cgc acc ttg cgt gaa ttc gcg ctc atc acc 1267Ala Arg Ile Ser Arg Gly Arg Thr Leu Arg Glu Phe Ala Leu Ile Thr

375 380 385atg gct atc ccc tcc ttc att ttg atc ctg gcg ttc acc att ttc ggt 1315Met Ala Ile Pro Ser Phe Ile Leu Ile Leu Ala Phe Thr Ile Phe Gly390 395 400 405gga act gcc atc acg atg aac cgc gag aac gta gat ggt ttt gac ggc 1363Gly Thr Ala Ile Thr Met Asn Arg Glu Asn Val Asp Gly Phe Asp Gly

410 415 420agt tca tcc aag gaa cag gtg ctg ttt gat atg ttc agc aac ctt ccg 1411Ser Ser Ser Lys Glu Gln Val Leu Phe Asp Met Phe Ser Asn Leu Pro

425 430 435ctg tac tcg atc aca ccg ttc att ttg atc ttt gtg ctg gca gta ttc 1459Leu Tyr Ser Ile Thr Pro Phe Ile Leu Ile Phe Val Leu Ala Val Phe

440 445 450ttt gtt acc tct gcc gat tcc gcc tcc gtg gtg atg gga acg atg agc 1507Phe Val Thr Ser Ala Asp Ser Ala Ser Val Val Met Gly Thr Met Ser

455 460 465tcc caa ggt aac cct gca cca aac aaa tta atc gtg gtg ttc tgg gga 1555Ser Gln Gly Asn Pro Ala Pro Asn Lys Leu Ile Val Val Phe Trp Gly470 475 480 485ctg tgc atg atg ggc atc gcg gtg gtc atg ctg ctt act ggt ggc gaa 1603Leu Cys Met Met Gly Ile Ala Val Val Met Leu Leu Thr Gly Gly Glu

490 495 500tcc gcg ctg act ggt ctg cag aac ctc acc att ttg atc gcc att ccg 1651Ser Ala Leu Thr Gly Leu Gln Asn Leu Thr Ile Leu Ile Ala Ile Pro

505 510 515ttt gcg ctg gtg ttg atc gtg atg gct att gcc ttt att aag gac tta 1699Phe Ala Leu Val Leu Ile Val Met Ala Ile Ala Phe Ile Lys Asp Leu

520 525 530tcc aca gac cca gcc gct att cga caa cgc tat gca aag gca gcc atc 1747Ser Thr Asp Pro Ala Ala Ile Arg Gln Arg Tyr Ala Lys Ala Ala Ile

535 540 545tct aac gcg gtg gtt cgt ggc ttg gaa gaa cac ggc gac gac ttc gag 1795Ser Asn Ala Val Val Arg Gly Leu Glu Glu His Gly Asp Asp Phe Glu550 555 560565ctc tcc atc gaa cct gca gag gaa ggt cgt gga gcg ggt gct acc ttc 1843Leu Ser Ile Glu Pro Ala Glu Glu Gly Arg Gly Ala Gly Ala Thr Phe

570 575 580gat tcc acc gct gat cac atc acc gac tgg tat cag cgc acc gac gaa 1891Asp Ser Thr Ala Asp His Ile Thr Asp Trp Tyr Gln Arg Thr Asp Glu

585 590 595gaa ggc aat gat gtt gat tat gac ttc acc acc ggc aaa tgg gcc gat 1939Glu Gly Asn Asp Val Asp Tyr Asp Phe Thr Thr Gly Lys Trp Ala Asp

600 605 610ggt tgg aca ccg gaa tcg acc gaa gaa ggc gaa gtg gac gcg aaa aag 1987Gly Trp Thr Pro Glu Ser Thr Glu Glu Gly Glu Val Asp Ala Lys Lys

615620625 gat taaaaaataa cgactggctg gga 2013Asp630<210>548<211>630<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>548Met Ser Thr Asn Ser Gly Asn Asn Leu Pro Glu Ser Gln Glu Ser Pro 151015 Glu Glu Pro His Tyr Pro His Asp Thr His Pro Gly Leu Val Pro Gly

20 25 30Ile Ser Val Asp Ala Gln Arg Asn Lys Phe Gly Leu Asp Lys Thr Val

35 40 45Phe Gly Val Thr Ala Ala Leu Ile Leu Ala Phe Ile Ala Trp Gly Ile

50 55 60Ser Ser Pro Asp Ser Val Ser Ser Val Ser Ser Thr Met Phe Ser Trp 65 70 75 80Ala Met Thr Asn Thr Gly Trp Leu Leu Asn Phe Val Met Leu Ile Gly

85 90 95Ile Gly Thr Met Leu Tyr Ile Ala Phe Ser Arg Tyr Gly Arg Ile Lys

100 105 110Leu Gly Thr Asp Glu Asp Glu Pro Glu Phe Ser Arg Phe SerTrp Ile

115 120 125Ala Met Met Phe Gly Ala Gly Ile Gly Val Gly Ile Phe Phe Phe Gly

130 135 140Pro Ser Glu Pro Leu Trp His Tyr Leu Ser Pro Pro Pro His Thr Val145 150 155 160Glu Gly Ser Thr Pro Glu Ser Leu His Gln Ala Leu Ala Gln Ser His

165 170 175Phe His Trp Gly Leu Ser Ala Trp Gly Leu Tyr Ala Leu Val Gly Gly

180 185 190Ala Leu Ala Tyr Ser Ser Tyr Arg Arg Gly Arg Val Thr Leu Ile Ser

195 200 205Ser Thr Phe Arg Ser Leu Phe Gly Glu Lys Thr Glu Gly Ile Ala Gly

210 215 220Arg Leu Ile Asp Met Met Ala Ile Ile Ala Thr Leu Phe Gly Thr Ala225 230 235 240Ala Thr Leu Gly Leu Ser Ala Ile Gln Val Gly Gln Gly Val Gln Ile

245 250 255Ile Ser Gly Ala Ser Glu Ile Thr Asn Asn Ile Leu Ile Ala Ile Ile

260 265 270Ala Ile Leu Thr Ile Gly Phe Ile Ile Ser Ser Val Ser Gly Val Ser

275 280 285Lys Gly Ile Arg Tyr Leu Ser Asn Leu Asn Ile Ser Leu Thr Leu Gly

290 295 300Leu Val Leu Phe Val Phe Ile Thr Gly Pro Thr Leu Phe Leu Leu Asn305 310 315 320Leu Ile Pro Ser Ser Val Leu Glu Tyr Gly Ser Glu Phe Leu Ser Met

325 330 335Ala Gly Lys Ser Leu Ser Trp Gly Glu Glu Thr Ile Glu Phe Gln Ala

340 345 350

Gly Trp Thr Ala Phe Tyr Trp Ala Trp Trp Ile Ala Trp Thr Pro Phe

355 360 365Val Gly Met Phe Ile Ala Arg Ile Ser Arg Gly Arg Thr Leu Arg Glu

370 375 380Phe Ala Leu Ile Thr Met Ala Ile Pro Ser Phe Ile Leu Ile Leu Ala385 390 395 400Phe Thr Ile Phe Gly Gly Thr Ala Ile Thr Met Asn Arg Glu Asn Val

405 410 415Asp Gly Phe Asp Gly Ser Ser Ser Lys Glu Gln Val Leu Phe Asp Met

420 425 430Phe Ser Asn Leu Pro Leu Tyr Ser Ile Thr Pro Phe Ile Leu Ile Phe

435 440 445Val Leu Ala Val Phe Phe Val Thr Ser Ala Asp Ser Ala Ser Val Val

450 455 460Met Gly Thr Met Ser Ser Gln Gly Asn Pro Ala Pro Asn Lys Leu Ile465 470 475 480Val Val Phe Trp Gly Leu Cys Met Met Gly Ile Ala Val Val Met Leu

485 490 495Leu Thr Gly Gly Glu Ser Ala Leu Thr Gly Leu Gln Asn Leu Thr Ile

500 505 510Leu Ile Ala Ile Pro Phe Ala Leu Val Leu Ile Val Met Ala Ile Ala

515 520 525Phe Ile Lys Asp Leu Ser Thr Asp Pro Ala Ala Ile Arg Gln Arg Tyr

530 535 540Ala Lys Ala Ala Ile Ser Asn Ala Val Val Arg Gly Leu Glu Glu His545 550 555 560Gly Asp Asp Phe Glu Leu Ser IleGlu Pro Ala Glu Glu Gly Arg Gly

565 570 575Ala Gly Ala Thr Phe Asp Ser Thr Ala Asp His Ile Thr Asp Trp Tyr

580 585 590Gln Arg Thr Asp Glu Glu Gly Asn Asp Val Asp Tyr Asp Phe Thr Thr

595 600 605Gly Lys Trp Ala Asp Gly Trp Thr Pro Glu Ser Thr Glu Glu Gly Glu

610615620 Val Asp Ala Lys Lys Asp 625630<210>549<211>2007<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1984)<223>RXN02348<400>549aaagacccga gccgaagccc tggcctgcgc atacttcctt gtcaacgctc gctgggatta 60ggtcttttct gagcgctagc atttctccac tcaaaggagc atg ctt aac cgc atg 115

Met Leu Asn Arg Met

1 5aaa agt gcg cgg cca aaa tca gtc gct cca aaa tcc gga caa gct tta 163Lys Ser Ala Arg Pro Lys Ser Val Ala Pro Lys Ser Gly Gln Ala Leu

10 15 20ctc act ctc ggt gcc cta ggt gtt gtg ttc ggc gac atc ggc acc agc 211Leu Thr Leu Gly Ala Leu Gly Val Val Phe Gly Asp Ile Gly Thr Ser

25 30 35ccc ctg tac tca ctt cac act gca ttc agc atg cag cac aac aaa gtc 259Pro Leu Tyr Ser Leu His Thr Ala Phe Ser Met Gln His Asn Lys Val

40 45 50gaa gtc act cag gaa aat gtg tac ggc atc atc tcc atg gtg ttg tgg 307Glu Val Thr Gln Glu Asn Val Tyr Gly Ile Ile Ser Met Val Leu Trp

55 60 65acc atc act ttg atc gtc acc gtc aaa tac gtc atg ctggtc acc cga 355Thr Ile Thr Leu Ile Val Thr Val Lys Tyr Val Met Leu Val Thr Arg 70 75 80 85gct gac aac caa gga caa ggt ggc atc ctg gcg ctc gtt gct ttg ctg 403Ala Asp Asn Gln Gly Gln Gly Gly Ile Leu Ala Leu Val Ala Leu Leu

90 95 100aaa aac cgt ggg cac tgg gga aaa ttc gtg gca gta gcc ggc atg ttg 451Lys Asn Arg Gly His Trp Gly Lys Phe Val Ala Val Ala Gly Met Leu

105 110 115ggc gcc gca ttg ttt tat ggc gat gtg gtg atc acc ccg gcg atc tct 499Gly Ala Ala Leu Phe Tyr Gly Asp Val Val Ile Thr Pro Ala Ile Ser

120 125 130gtt ctc agc gca aca gaa ggc ttg acg gtt atc tcc cca agc ttt gag 547Val Leu Ser Ala Thr Glu Gly Leu Thr Val Ile Ser Pro Ser Phe Glu

135 140 145cgc ttc att ctg ccc gta tct ctc gca gtt ctg atc gct att ttt gca 595Arg Phe Ile Leu Pro Val Ser Leu Ala Val Leu Ile Ala Ile Phe Ala150 155 160 165atc caa ccg ctc ggt aca gaa aaa gtc ggc aaa gcc ttc ggc ccc atc 643Ile Gln Pro Leu Gly Thr Glu Lys Val Gly Lys Ala Phe Gly Pro Ile

170 175 180atg ttg ctg tgg ttt gtc acc ctt gca gga ttg gga att ccg caa atc 691Met Leu Leu Trp Phe Val Thr Leu Ala Gly Leu Gly Ile Pro Gln Ile

185 190 195atc ggg cac cca gaa atc ttg cag agc ttg tct cca cat tgg gcc ctg 739Ile Gly His Pro Glu Ile Leu Gln Ser Leu Ser Pro His Trp Ala Leu

200 205 210cgc ttg att gtg gct gag cct ttc caa gca ttt gtg ctg ctt ggt gcc 787Arg Leu Ile Val Ala Glu Pro Phe Gln Ala Phe Val Leu Leu Gly Ala

215 220 225gtt gtc ctg aca gta acg ggt gcg gaa gcg ctc tac gct gat atg ggc 835Val Val Leu Thr Val Thr Gly Ala Glu Ala Leu Tyr Ala Asp Met Gly230 235 240 245cat ttt ggg gcg agg cca atc aga gtg gcg tgg ttt tgc gtc gtc atg 883His Phe Gly Ala Arg Pro Ile Arg Val Ala Trp Phe Cys Val Val Met

250 255 260cct gct tta atc ttg acg tat ttg ggg cag ggc gcc ttg gtg atc aac 931Pro Ala Leu Ile Leu Thr Tyr Leu Gly Gln Gly Ala Leu Val Ile Asn

265 270 275cag cct gaa gcg gtg cgc aac ccc atg ttt tat ctc gcg ccg gaa ggt 979Gln Pro Glu Ala Val Arg Asn Pro Met Phe Tyr Leu Ala Pro Glu Gly

280 285 290ctg cgg att ccg ttg gtt att ttg gcg acc atc gct acg gtg atc gca 1027Leu Arg Ile Pro Leu Val Ile Leu Ala Thr Ile Ala Thr Val Ile Ala

295 300 305tcg cag gcc gtg att tct ggt gcg tat tca ttg acc aag cag gcc gtg 1075Ser Gln Ala Val Ile Ser Gly Ala Tyr Ser Leu Thr Lys Gln Ala Val310 315 320 325aat ttg aaa ctg ctg cca cgc atg gtg atc cgg cat acc tcc cgc aaa 1123Asn Leu Lys Leu Leu Pro Arg Met Val Ile Arg His Thr Ser Arg Lys

330 335 340gag gaa ggc cag atc tat atg cca ctg gtt aat gga ttg ctg ttt gta 1171Glu Glu Gly Gln Ile Tyr Met Pro Leu Val Asn Gly Leu Leu Phe Val

345 350 355tcc gtg atg gtt gtg gtg ctg gta ttc cga tcc tct gaa agc ctc gcc 1219Ser Val Met Val Val Val Leu Val Phe Arg Ser Ser Glu Ser Leu Ala

360 365 370agc gcg tac gga ctt gca gtg acc gga acc ttg gtg ctg gtc agc gtc 1267Ser Ala Tyr Gly Leu Ala Val Thr Gly Thr Leu Val Leu Val Ser Val

375 380 385ctg tat ctg atc tat gtt cac acc aca tgg tgg aaa aca gcg ctg ttc 1315Leu Tyr Leu Ile Tyr Val His Thr Thr Trp Trp Lys Thr Ala Leu Phe390 395 400 405att gtg ctc atc ggt att cca gaa gta ctt cta ttc gcc tcg aac acc 1363Ile Val Leu Ile Gly Ile Pro Glu Val Leu Leu Phe Ala Ser Asn Thr

410 415 420acg aaa att cac gac ggt ggc tgg ctt cca cta ctt att gcg gcc gtg 1411Thr Lys Ile His Asp Gly Gly Trp Leu Pro Leu Leu Ile Ala Ala Val

425 430 435ctc atc gtg gtg atg cgg acc tgg gag tgg gga agt gac cgc gtc aat 1459Leu Ile Val Val Met Arg Thr Trp Glu Trp Gly Ser Asp Arg Val Asn

440 445 450cag gaa cgc gca gag ctg gaa ctt ccc atg gat aag ttc ttg gag aaa 1507Gln Glu Arg Ala Glu Leu Glu Leu Pro Met Asp Lys Phe Leu Glu Lys

455 460 465ctc gat cag cca cac aat att ggt ctg cgt aaa gtt gcc gaa gtg gca 1555Leu Asp Gln Pro His Asn Ile Gly Leu Arg Lys Val Ala Glu Val Ala470 475 480 485gta ttt cca cat ggc acc agc gat act gtc ccg ttg tca ttg gtt cgc 1603Val Phe Pro His Gly Thr Ser Asp Thr Val Pro Leu Ser Leu Val Arg

490 495 500tgc gtg aaa gac ctc aag ctt tta tac cga gag atc gtg atc gtt cga 1651Cys Val Lys Asp Leu Lys Leu Leu Tyr Arg Glu Ile Val Ile Val Arg

505 510 515atc gtc caa gaa cac gtt ccg cac gtg cca cca gag gaa cgc gcg gaa 1699Ile Val Gln Glu His Val Pro His Val Pro Pro Glu Glu ArgAla Glu

520 525 530atg gaa gtg ctc cat cac gcc ccg atc aga gtc gtg cga gtt gat ctg 1747Met Glu Val Leu His His Ala Pro Ile Arg Val Val Arg Val Asp Leu

535 540 545cac ctt ggt tat ttt gat gag cag aac ctg cct gag cat ctc cat gcc 1795His Leu Gly Tyr Phe Asp Glu Gln Asn Leu Pro Glu His Leu His Ala550 555 560 565att gac cca aca tgg gat aac gcc acc tac ttc ctg tct gcc ctg act 1843Ile Asp Pro Thr Trp Asp Asn Ala Thr Tyr Phe Leu Ser Ala Leu Thr

570 575 580ctt cgg agc agg ttg cct gga aag att gct ggc tgg cgt gat cgt ttg 1891Leu Arg Ser Arg Leu Pro Gly Lys Ile Ala Gly Trp Arg Asp Arg Leu

585 590 595tat ctt tcg atg gaa cgt aat cag gca tct cga act gag tct ttc aaa 1939Tyr Leu Ser Met Glu Arg Asn Gln Ala Ser Arg Thr Glu Ser Phe Lys

600 605 610ttg caa cca agc aaa acc atc acg gtt gga aca gag ctg cac ctt 1984Leu Gln Pro Ser Lys Thr Ile Thr Val Gly Thr Glu Leu His Leu

615620625 taatcaggca gttgctggcc aac 2007<210>550<211>628<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>550Met Leu Asn Arg Met Lys Ser Ala Arg Pro Lys Ser Val Ala Pro Lys 151015 Ser Gly Gln Ala Leu Leu Thr Leu Gly Ala Leu Gly Val Val Phe Gly

20 25 30Asp Ile Gly Thr Ser Pro Leu Tyr Ser Leu His Thr Ala Phe Ser Met

35 40 45Gln His Asn Lys Val Glu Val Thr Gln Glu Asn Val Tyr Gly Ile Ile

50 5560Ser Met Val Leu Trp Thr Ile Thr Leu Ile Val Thr Val Lys Tyr Val 65 70 75 80Met Leu Val Thr Arg Ala Asp Asn Gln Gly Gln Gly Gly Ile Leu Ala

85 90 95Leu Val Ala Leu Leu Lys Asn Arg Gly His Trp Gly Lys Phe Val Ala

100 105 110Val Ala Gly Met Leu Gly Ala Ala Leu Phe Tyr Gly Asp Val Val Ile

115 120 125Thr Pro Ala Ile Ser Val Leu Ser Ala Thr Glu Gly Leu Thr Val Ile

130 135 140Ser Pro Ser Phe Glu Arg Phe Ile Leu Pro Val Ser Leu Ala Val Leu145 150 155 160Ile Ala Ile Phe Ala Ile Gln Pro Leu Gly Thr Glu Lys Val Gly Lys

165 170 175Ala Phe Gly Pro Ile Met Leu Leu Trp Phe Val Thr Leu Ala Gly Leu

180 185 190Gly Ile Pro Gln Ile Ile Gly His Pro Glu Ile Leu Gln Ser Leu Ser

195 200 205Pro His Trp Ala Leu Arg Leu Ile Val Ala Glu Pro Phe Gln Ala Phe

210 215 220Val Leu Leu Gly Ala Val Val Leu Thr Val Thr Gly Ala Glu Ala Leu225 230 235 240Tyr Ala Asp Met Gly His Phe Gly Ala Arg Pro Ile Arg Val Ala Trp

245 250 255Phe Cys Val Val Met Pro Ala Leu Ile Leu Thr Tyr Leu Gly Gln Gly

260 265 270Ala Leu Val Ile Asn Gln Pro Glu Ala Val Arg Asn Pro Met Phe Tyr

275 280 285Leu Ala Pro Glu Gly Leu Arg Ile Pro Leu Val Ile Leu Ala Thr Ile

290 295 300Ala Thr Val Ile Ala Ser Gln Ala Val Ile Ser Gly Ala Tyr Ser Leu305 310 315 320Thr Lys Gln Ala Val Asn Leu Lys Leu Leu Pro Arg Met Val Ile Arg

325 330 335His Thr Ser Arg Lys Glu Glu Gly Gln Ile Tyr Met Pro Leu Val Asn

340 345 350Gly Leu Leu Phe Val Ser Val Met Val Val Val Leu Val Phe Arg Ser

355 360 365Ser Glu Ser Leu Ala Ser Ala Tyr Gly Leu Ala Val Thr Gly Thr Leu

370 375 380Val Leu Val Ser Val Leu Tyr Leu Ile Tyr Val His Thr Thr Trp Trp385 390 395 400Lys Thr Ala Leu Phe Ile Val Leu Ile Gly Ile Pro Glu Val Leu Leu

405 410 415Phe Ala Ser Asn Thr Thr Lys Ile His Asp Gly Gly Trp Leu Pro Leu

420 425 430Leu Ile Ala Ala Val Leu Ile Val Val Met Arg Thr Trp Glu Trp Gly

435 440 445Ser Asp Arg Val Asn Gln Glu Arg Ala Glu Leu Glu Leu Pro Met Asp

450 455 460Lys Phe Leu Glu Lys Leu Asp Gln Pro His Asn Ile Gly Leu Arg Lys465 470 475 480Val Ala Glu Val Ala Val Phe Pro His Gly Thr Ser Asp Thr Val Pro

485 490 495Leu Ser Leu Val Arg Cys Val Lys Asp Leu Lys Leu Leu Tyr Arg Glu

500 505510Ile Val Ile Val Arg Ile Val Gln Glu His Val Pro His Val Pro Pro

515 520 525Glu Glu Arg Ala Glu Met Glu Val Leu His His Ala Pro Ile Arg Val

530 535 540Val Arg Val Asp Leu His Leu Gly Tyr Phe Asp Glu Gln Asn Leu Pro545 550 555 560Glu His Leu His Ala Ile Asp Pro Thr Trp Asp Asn Ala Thr Tyr Phe

565 570 575Leu Ser Ala Leu Thr Leu Arg Ser Arg Leu Pro Gly Lys Ile Ala Gly

580 585 590Trp Arg Asp Arg Leu Tyr Leu Ser Met Glu Arg Asn Gln Ala Ser Arg

595 600 605Thr Glu Ser Phe Lys Leu Gln Pro Ser Lys Thr Ile Thr Val Gly Thr

610615620 Glu Leu His Leu625<210>551<211>1035<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1012)<223>RXN00297<400>551aacaaggcac cggaaaacaa gcaacgcacc ttgcagaggt ggtcttaagc atcttggagc 60aaaacaacat ggcacaataa cgatcatgca acaggtgctc atg ggt ttc acg gtg 115

Met Gly Phe Thr Val

1 5gtg ttc atc gtc atc gga ata ggt tgg att ctc ggt aga aga gac acc 163Val Phe Ile Val Ile Gly Ile Gly Trp Ile Leu Gly Arg Arg Asp Thr

10 15 20ttg ggc aca cat gcc cag aaa cct ttg agc ctg ttt gtc tat tac gtg 211Leu Gly Thr His Ala Gln Lys Pro Leu Ser Leu Phe Val Tyr Tyr Val

25 30 35gcc acc cca gcg ttg ttg ttt gat cgg gtc acc aag tca gat acc tcg 259Ala Thr Pro Ala Leu Leu Phe Asp Arg Val Thr Lys Ser Asp Thr Ser

40 45 50acg att ttc tct ctg aac ttc gtg gtc att gca ctc tct gcg ttg atc 307Thr Ile Phe Ser Leu Asn Phe Val Val Ile Ala Leu Ser Ala Leu Ile

55 60 65gta ggt ttc ctg ttt ttc cta ctc atg cgg ttc gtg atc aaa aga act 355Val Gly Phe Leu Phe Phe Leu Leu Met Arg Phe Val Ile Lys Arg Thr 70 75 80 85gcc gca gta tcg gtg atc ggc atg cta gct gcg tcc tac gcc aac gcc 403Ala Ala Val Ser Val Ile Gly Met Leu Ala Ala Ser Tyr Ala Asn Ala

90 95 100ggt aac ctg ggt atc cct ttg gca gcc tat att ttg gat gat ttc acc 451Gly Asn Leu Gly Ile Pro Leu Ala Ala Tyr Ile Leu Asp Asp Phe Thr

105 110 115gtg gtg att ccc gtg att ttg ttc cag gtg gcg ttc tac gca ccg atc 499Val Val Ile Pro Val Ile Leu Phe Gln Val Ala Phe Tyr Ala Pro Ile

120 125 130acc atg acc atc atg gag atg ctg acc aac aag aaa tcc acc aac ttg 547Thr Met Thr Ile Met Glu Met Leu Thr Asn Lys Lys Ser Thr Asn Leu

135 140 145gtg cgc aac ctc ctg gtc acg cca cta acc aac acc atg gtg ctc gca 595Val Arg Asn Leu Leu Val Thr Pro Leu Thr Asn Thr Met Val Leu Ala150 155 160 165gcg att gcc ggt att gct gtg tct ttg act tcg atg agc gtg ccc gtg 643Ala Ile Ala Gly Ile Ala Val Ser Leu Thr Ser Met Ser Val Pro Val

170 175 180gtg att gct cag cca gtg gaa atg ttg gcg aat gct tca gtg cca ctg 691Val Ile Ala Gln Pro Val Glu Met Leu Ala Asn Ala Ser Val Pro Leu

185 190 195gct ttg gtg gtg ttc gga ctg tcc ttg tcc aag agc aag atc ctg gaa 739Ala Leu Val Val Phe Gly Leu Ser Leu Ser Lys Ser Lys Ile Leu Glu

200 205 210aag ggg cag gta tcc agg cgc gat gtg ttt acg gcg gca ctg ttc aag 787Lys Gly Gln Val Ser Arg Arg Asp Val Phe Thr Ala Ala Leu Phe Lys

215 220 225aat gtt ctg cac cca att gtt gcg gga ctt tta gcc tta gcc ttt ggt 835Asn Val Leu His Pro Ile Val Ala Gly Leu Leu Ala Leu Ala Phe Gly230 235 240 245atg gaa ggt act gcc ttg ttg tcg gcg gtg att ctc ggt gca ctg cca 883Met Glu Gly Thr Ala Leu Leu Ser Ala Val Ile Leu Gly Ala Leu Pro

250 255 260aca gcg cag aat gtc tac acc tac gcg ttg cga ttt aga aca gct gaa 931Thr Ala Gln Asn Val Tyr Thr Tyr Ala Leu Arg Phe Arg Thr Ala Glu

265 270 275tcg atg gcg aga gac aca ggg gtg gtc acc aca ctc att tcc ttc ccc 979Ser Met Ala Arg Asp Thr Gly Val Val Thr Thr Leu Ile Ser Phe Pro

280 285 290gta ttg gtg gcg gtc tcc att atc ttt gga tct tagggttagc attagtggtc 1032Val Leu Val Ala Val Ser Ile Ile Phe Gly Ser

295300 atg1035<210>552<211>304<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>552Met Gly Phe Thr Val Val Phe Ile Val Ile Gly Ile Gly Trp Ile Leu 151015 Gly Arg Arg Asp Thr Leu Gly Thr His Ala Gln Lys Pro Leu Ser Leu

20 25 30Phe Val Tyr Tyr Val Ala Thr Pro Ala Leu Leu Phe Asp Arg Val Thr

35 40 45Lys Ser Asp Thr Ser Thr Ile Phe Ser Leu Asn Phe Val Val Ile Ala

50 55 60Leu Ser Ala Leu Ile Val Gly Phe Leu Phe Phe Leu Leu Met Arg Phe 65 70 75 80Val Ile Lys Arg Thr Ala Ala Val Ser Val Ile Gly Met Leu Ala Ala

85 90 95Ser Tyr Ala Asn Ala Gly Asn Leu Gly Ile Pro Leu Ala Ala Tyr Ile

100 105 110Leu Asp Asp Phe Thr Val Val Ile Pro Val Ile Leu Phe Gln Val Ala

115 120 125Phe Tyr Ala Pro Ile Thr Met Thr Ile Met Glu Met Leu Thr Asn Lys

130 135 140Lys Ser Thr Asn Leu Val Arg Asn Leu Leu Val Thr Pro Leu Thr Asn145 150 155 160Thr Met Val Leu Ala Ala Ile Ala Gly Ile Ala Val Ser Leu Thr Ser

165 170 175Met Ser Val Pro Val Val Ile Ala Gln Pro Val Glu Met Leu Ala Asn

180 185 190Ala Ser Val Pro Leu Ala Leu Val Val Phe Gly Leu Ser Leu Ser Lys

195 200 205Ser Lys Ile Leu Glu Lys Gly Gln Val Ser Arg Arg Asp Val Phe Thr

210 215 220Ala Ala Leu Phe Lys Asn Val Leu His Pro Ile Val Ala Gly Leu Leu225 230 235 240Ala Leu Ala Phe Gly Met Glu Gly Thr Ala Leu Leu Ser Ala Val Ile

245 250 255Leu Gly Ala Leu Pro Thr Ala Gln Asn Val Tyr Thr Tyr Ala Leu Arg

260 265270Phe Arg Thr Ala Glu Ser Met Ala Arg Asp Thr Gly Val Val Thr Thr

275 280 285Leu Ile Ser Phe Pro Val Leu Val Ala Val Ser Ile Ile Phe Gly Ser

290295300<210>553<211>353<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (343)<223>RXN03103<400>553atcttcagag tcacttcttt cagtgtcatt tttctcggcc ctaatccccc gctggagttc 60aatcagcgat tgcaaccttt tagatatata aggagacaac atg tct gca aag cgt 115

Met Ser Ala Lys Arg

1 5act ttt acc cgt atc ggt gcg att ctt gga gca act gca ctt gcc gga 163Thr Phe Thr Arg Ile Gly Ala Ile Leu Gly Ala Thr Ala Leu Ala Gly

10 15 20gtt acc ctc acc gcc tgt ggt gat tca agc ggt ggc gac gga ttc ctc 211Val Thr Leu Thr Ala Cys Gly Asp Ser Ser Gly Gly Asp Gly Phe Leu

25 30 35gca gcc att gaa aat ggt tct gtc aat gtc ggc acc aaa tac gat cag 259Ala Ala Ile Glu Asn Gly Set Val Asn Val Gly Thr Lys Tyr Asp Gln

40 45 50cct ggt ctt ggc ctc cgc aac cca gac aac tcc atg agc ggt ctc gac 307Pro Gly Leu Gly Leu Arg Asn Pro Asp Asn Ser Met Ser Gly Leu Asp

556065 gtg gat gtt gct gaa tac gta att caa ctc cat cgc tgatgacaag 353Val Asp Val Ala Glu Tyr Val Ile Gln Leu His Arg 707580<210>554<211>81<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>554Met Ser Ala Lys Arg Thr Phe Thr Arg Ile Gly Ala Ile Leu Gly Ala 151015 Thr Ala Leu Ala Gly Val Thr Leu Thr Ala Cys Gly Asp Ser Ser Gly

20 25 30Gly Asp Gly Phe Leu Ala Ala Ile Glu Asn Gly Ser Val Asn Val Gly

35 40 45Thr Lys Tyr Asp Gln Pro Gly Leu Gly Leu Arg Asn Pro Asp Asn Ser

505560 Met Ser Gly Leu Asp Val Asp Val Ala Glu Tyr Val Ile Gln Leu His 65707580 Arg<210>555<211>695<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1).<672)<223>RXN02993<400>555gtt gct gaa tac gta gtc aac tcc atc gct gat gac aag ggc tgg gat 48Val Ala Glu Tyr Val Val Asn Ser Ile Ala Asp Asp Lys Gly Trp Asp 151015 cac ccc acc atc gaa tgg cgt gaa tcc cct tct gcg cag cgt gaa acc 96His Pro Thr Ile Glu Trp Arg Glu Ser Pro Ser Ala Gln Arg Glu Thr

20 25 30ctc att caa aac ggt gag gta gac atg atc gca gca acc tac tcc atc 144Leu Ile Gln Asn Gly Glu Val Asp Met Ile Ala Ala Thr Tyr Ser Ile

35 40 45aac gct ggc cgt tca gag tcc gtc aac ttc ggt ggc cca tac ctg ctt 192Asn Ala Gly Arg Ser Glu Ser Val Asn Phe Gly Gly Pro Tyr Leu Leu

50 55 60acc cac cag gct ctg ctt gtt cgc caa gat gac gat cgc att gaa acc 240Thr His Gln Ala Leu Leu Val Arg Gln Asp Asp Asp Arg Ile Glu Thr 65 70 75 80ctc gag gac ttg gat aac ggt ttg atc ctg tgc tcc gtt tcc gga tcc 288Leu Glu Asp Leu Asp Asn Gly Leu Ile Leu Cys Ser Val Ser Gly Ser

85 90 95act cca gct cag aag gtc aag gat gtc ctc cca ggc gtt cag ctc caa 336Thr Pro Ala Gln Lys Val Lys Asp Val Leu Pro Gly Val Gln Leu Gln

100 105110gaa tac gac acc tac tct tcc tgt gtt gag gca ctg tcc cag ggc aac 384Glu Tyr Asp Thr Tyr Ser Ser Cys Val Glu Ala Leu Ser Gln Gly Asn

115 120 125gtt gac gcc ctg acc act gac gcc acc atc ctc ttc ggc tac tcc cag 432Val Asp Ala Leu Thr Thr Asp Ala Thr Ile Leu Phe Gly Tyr Ser Gln

130 135 140cag tac gaa ggc gac ttc cgc gtt gtg gaa atg gaa aag gac ggc gag 480Gln Tyr Glu Gly Asp Phe Arg Val Val Glu Met Glu Lys Asp Gly Glu145 150 155 160cca ttc acc gac gag tac tac ggc att ggc ctg aag aag gat gac cag 528Pro Phe Thr Asp Glu Tyr Tyr Gly Ile Gly Leu Lys Lys Asp Asp Gln

165 170 175gaa ggc acc gac gct atc aac gcc gca ctt gag cgc atg tac gct gac 576Glu Gly Thr Asp Ala Ile Asn Ala Ala Leu Glu Arg Met Tyr Ala Asp

180 185 190ggc acc ttc cag cga ctg ctc acc gag aac ctc ggt gaa gac tcc gtg 624Gly Thr Phe Gln Arg Leu Leu Thr Glu Asn Leu Gly Glu Asp Ser Val

195 200 205gtt gtt gaa gaa ggc acc cca ggt gac ctc tcc ttc ctc gac gca agc 672Val Val Glu Glu Gly Thr Pro Gly Asp Leu Ser Phe Leu Asp Ala Ser

210215220 tagtgtgacg gcttttaaaa gcc 695<210>556<211>224<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>556Val Ala Glu Tyr Val Val Asn Ser Ile Ala Asp Asp Lys Gly Trp Asp 151015 His Pro Thr Ile Glu Trp Arg Glu Ser Pro Ser Ala Gln Arg Glu Thr

20 25 30Leu Ile Gln Asn Gly Glu Val Asp Met Ile Ala Ala Thr Tyr Ser Ile

35 40 45Asn Ala Gly Arg Ser Glu Ser Val Asn Phe Gly Gly Pro Tyr Leu Leu

50 55 60Thr His Gln Ala Leu Leu Val Arg Gln Asp Asp Asp Arg Ile Glu Thr 65 70 75 80Leu Glu Asp Leu Asp Asn Gly Leu Ile Leu Cys Ser Val Ser Gly Ser

85 90 95Thr Pro Ala Gln Lys Val Lys Asp Val Leu Pro Gly Val Gln Leu Gln

100 105 110Glu Tyr Asp Thr Tyr Ser Ser Cys Val Glu Ala Leu Ser Gln Gly Asn

115 120 125Val Asp Ala Leu Thr Thr Asp Ala Thr Ile Leu Phe Gly Tyr Ser Gln

130 135 140Gln Tyr Glu Gly Asp Phe Arg Val Val Glu Met Glu Lys Asp Gly Glu145 150 155 160Pro Phe Thr Asp Glu Tyr Tyr Gly Ile Gly Leu Lys Lys Asp Asp Gln

165 170 175Glu Gly Thr Asp Ala Ile Asn Ala Ala Leu Glu Arg Met Tyr Ala Asp

180 185 190Gly Thr Phe Gln Arg Leu Leu Thr Glu Asn Leu Gly Glu Asp Ser Val

195 200 205Val Val Glu Glu Gly Thr Pro Gly Asp Leu Ser Phe Leu Asp Ala Ser

210215220<210>557<211>1590<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1567)<223>RXN00349<400>557tgtgtacatc acaatggaat tcggggctag agtatctggt gaaccgtgca taaacgacct 60gtgattggac tctttttcct tgcaaaatgt tttccagcgg atg ttg agt ttt gcg 115

Met Leu Ser Phe Ala

1 5acc ctt cgt ggc cgc att tca aca gtt gac gct gca aaa gcc gca cct 163Thr Leu Arg Gly Arg Ile Ser Thr Val Asp Ala Ala Lys Ala Ala Pro

10 15 20ccg cca tcg cca cta gcc ccg att gat ctc act gac cat agt caa gtg 211Pro Pro Ser Pro Leu Ala Pro Ile Asp Leu Thr Asp His Ser Gln Val

25 30 35gcc ggt gtg atg aat ttg gct gcg aga att ggc gat att ttg ctt tct 259Ala Gly Val Met Asn Leu Ala Ala Arg Ile Gly Asp Ile Leu Leu Ser

40 45 50tca ggt acg tca aat agt gac acc aag gta caa gtt cga gca gtg acc 307Ser Gly Thr Ser Asn Ser Asp Thr Lys Val Gln Val Arg Ala Val Thr

55 60 65tct gcg tac ggt ttg tac tac acg cac gtg gat atc acg ttg aat acg 355Ser Ala Tyr Gly Leu Tyr Tyr Thr His Val Asp Ile Thr Leu Asn Thr70 75 80 85atc acc atc ttc acc aac atc ggt gtg gag agg aag atg ccg gtc aac 403Ile Thr Ile Phe Thr Asn Ile Gly Val Glu Arg Lys Met Pro Val Asn

90 95 100gtg ttt cat gtt gta ggc aag ttg gac acc aac ttc tcc aaa ctg tct 451Val Phe His Val Val Gly Lys Leu Asp Thr Asn Phe Ser Lys Leu Ser

105 110 115gag gtt gac cgt ttg atc cgt tcc att cag gct ggt gcg acc ccg cct 499Glu Val Asp Arg Leu Ile Arg Ser Ile Gln Ala Gly Ala Thr Pro Pro

120 125 130gag gtt gcc gag aaa atc ctg gac gag ttg gag caa tcc cct gcg tct 547Glu Val Ala Glu Lys Ile Leu Asp Glu Leu Glu Gln Ser Pro Ala Ser

135 140 145tat ggt ttc cctgtt gcg ttg ctt ggc tgg gca atg atg ggt ggt gct 595Tyr Gly Phe Pro Val Ala Leu Leu Gly Trp Ala Met Met Gly Gly Ala150 155 160 165gtt gct gtg ctg ttg ggt ggt gga tgg cag gtt tcc cta att gct ttt 643Val Ala Val Leu Leu Gly Gly Gly Trp Gln Val Ser Leu Ile Ala Phe

170 175 180att acc gcg ttc acg atc att gcc acg acg tca ttt ttg gga aag aag 691Ile Thr Ala Phe Thr Ile Ile Ala Thr Thr Ser Phe Leu Gly Lys Lys

185 190 195ggt ttg cct act ttc ttc caa aat gtt gtt ggt ggt ttt att gcc acg 739Gly Leu Pro Thr Phe Phe Gln Asn Val Val Gly Gly Phe Ile Ala Thr

200 205 210ctg cct gca tcg att gct tat tct ttg gcg ttg caa ttt ggt ctt gag 787Leu Pro Ala Ser Ile Ala Tyr Ser Leu Ala Leu Gln Phe Gly Leu Glu

215 220 225atc aaa ccg agc cag atc atc gca tct gga att gtt gtg ctg ttg gca 835Ile Lys Pro Ser Gln Ile Ile Ala Ser Gly Ile Val Val Leu Leu Ala230 235 240 245ggt ttg aca ctc gtg caa tct ctg cag gac ggc atc acg ggc gct ccg 883Gly Leu Thr Leu Val Gln Ser Leu Gln Asp Gly Ile Thr Gly Ala Pro

250 255 260gtg aca gca agt gca cga ttt ttc gaa aca ctc ctg ttt acc ggc ggc 931Val Thr Ala Ser Ala Arg Phe Phe Glu Thr Leu Leu Phe Thr Gly Gly

265 270 275att gtt gct ggc gtg ggt ttg ggc att cag ctt tct gaa atc ttg cat 979Ile Val Ala Gly Val Gly Leu Gly Ile Gln Leu Ser Glu Ile Leu His

280 285 290gtc atg ttg cct gcc atg gag tcc gct gca gca cct aat tat tcg tct 1027Val Met Leu Pro Ala Met Glu Ser Ala Ala Ala Pro Asn Tyr Ser Ser

295 300 305aca ttc gcc cgc att atc gct ggt ggc gtc acc gca gcg gcc ttc gca 1075Thr Phe Ala Arg Ile Ile Ala Gly Gly Val Thr Ala Ala Ala Phe Ala310 315 320 325gtg ggt tgt tac gcg gag tgg tcc tcg gtg att att gcg ggg ctt act 1123Val Gly Cys Tyr Ala Glu Trp Ser Ser Val Ile Ile Ala Gly Leu Thr

330 335 340gcg ctg atg ggt tct gcg ttt tat tac ctc ttc gtt gtt tat tta ggc 1171Ala Leu Met Gly Ser Ala Phe Tyr Tyr Leu Phe Val Val Tyr Leu Gly

345 350 355ccc gtc tct gcc gct gcg att gct gca aca gca gtt ggt ttc act ggt 1219Pro Val Ser Ala Ala Ala Ile Ala Ala Thr Ala Val Gly Phe Thr Gly

360 365 370ggt ttg ctt gcc cgt cga ttc ttg att cca ccg ttg att gtg gcg att 1267Gly Leu Leu Ala Arg Arg Phe Leu Ile Pro Pro Leu Ile Val Ala Ile

375 380 385gcc ggc atc aca cca atg ctt cca ggt cta gca att tac cgc gga atg 1315Ala Gly Ile Thr Pro Met Leu Pro Gly Leu Ala Ile Tyr Arg Gly Met390 395 400 405tac gcc acc ctg aat gat caa aca ctc atg ggt ttc acc aac att gcg 1363Tyr Ala Thr Leu Asn Asp Gln Thr Leu Met Gly Phe Thr Asn Ile Ala

410 415 420gtt gct tta gcc act gct tca tca ctt gcc gct ggc gtg gtt ttg ggt 1411Val Ala Leu Ala Thr Ala Ser Ser Leu Ala Ala Gly Val Val Leu Gly

425 430 435gag tgg att gcc cgc agg cta cgt cgt cca cca cgc ttc aac cca tac 1459Glu Trp Ile Ala Arg Arg Leu Arg Arg Pro Pro Arg Phe Asn Pro Tyr

440 445450cgt gca ttt acc aag gcg aat gag ttc tcc ttc cag gag gaa gct gag 1507Arg Ala Phe Thr Lys Ala Asn Glu Phe Ser Phe Gln Glu Glu Ala Glu

455460465 cag aat cag cgc cgg cag aga aaa cgt cca aag act aat cag aga ttc 1555Gln Asn Gln Arg Arg Gln Arg Lys Arg Pro Lys Thr Asn Gln Arg Phe 470475480485 ggt aat aaa agg taaaaatcaa cctgcttagg cgt 1590Gly Asn Lys Arg<210>558<211>489<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>558Met Leu Ser Phe Ala Thr Leu Arg Gly Arg Ile Ser Thr Val Asp Ala 151015 Ala Lys Ala Ala Pro Pro Pro Ser Pro Leu Ala Pro Ile Asp Leu Thr

20 25 30Asp His Ser Gln Val Ala Gly Val Met Asn Leu Ala Ala Arg Ile Gly

35 40 45Asp Ile Leu Leu Ser Ser Gly Thr Ser Asn Ser Asp Thr Lys Val Gln

50 55 60Val Arg Ala Val Thr Ser Ala Tyr Gly Leu Tyr Tyr Thr His Val Asp 65 70 75 80Ile Thr Leu Asn Thr Ile Thr Ile Phe Thr Asn Ile Gly Val Glu Arg

85 90 95Lys Met Pro Val Asn Val Phe His Val Val Gly Lys Leu Asp Thr Asn

100 105 110Phe Ser Lys Leu Ser Glu Val Asp Arg Leu Ile Arg Ser Ile Gln Ala

115 120 125Gly Ala Thr Pro Pro Glu Val Ala Glu Lys Ile Leu Asp Glu Leu Glu

130 135 140Gln Ser Pro Ala Ser Tyr Gly Phe Pro Val Ala Leu Leu Gly Trp Ala145 150 155 160Met Met Gly Gly Ala Val Ala Val Leu Leu Gly Gly Gly Trp Gln Val

165 170175Ser Leu Ile Ala Phe Ile Thr Ala Phe Thr Ile Ile Ala Thr Thr Ser

180 185 190Phe Leu Gly Lys Lys Gly Leu Pro Thr Phe Phe Gln Asn Val Val Gly

195 200 205Gly Phe Ile Ala Thr Leu Pro Ala Ser Ile Ala Tyr Ser Leu Ala Leu

210 215 220Gln Phe Gly Leu Glu Ile Lys Pro Ser Gln Ile Ile Ala Ser Gly Ile225 230 235 240Val Val Leu Leu Ala Gly Leu Thr Leu Val Gln Ser Leu Gln Asp Gly

245 250 255Ile Thr Gly Ala Pro Val Thr Ala Ser Ala Arg Phe Phe Glu Thr Leu

260 265 270Leu Phe Thr Gly Gly Ile Val Ala Gly Val Gly Leu Gly Ile Gln Leu

275 280 285Ser Glu Ile Leu His Val Met Leu Pro Ala Met Glu Ser Ala Ala Ala

290 295 300Pro Asn Tyr Ser Ser Thr Phe Ala Arg Ile Ile Ala Gly Gly Val Thr305 310 315 320Ala Ala Ala Phe Ala Val Gly Cys Tyr Ala Glu Trp Ser Ser Val Ile

325 330 335Ile Ala Gly Leu Thr Ala Leu Met Gly Ser Ala Phe Tyr Tyr Leu Phe

340 345 350Val Val Tyr Leu Gly Pro Val Ser Ala Ala Ala Ile Ala Ala Thr Ala

355 360 365Val Gly Phe Thr Gly Gly Leu Leu Ala Arg Arg Phe Leu Ile Pro Pro

370 375 380Leu Ile Val Ala Ile Ala Gly Ile Thr Pro Met Leu Pro Gly Leu Ala385 390 395400Ile Tyr Arg Gly Met Tyr Ala Thr Leu Asn Asp Gln Thr Leu Met Gly

405 410 415Phe Thr Asn Ile Ala Val Ala Leu Ala Thr Ala Ser Ser Leu Ala Ala

420 425 430Gly Val Val Leu Gly Glu Trp Ile Ala Arg Arg Leu Arg Arg Pro Pro

435 440 445Arg Phe Asn Pro Tyr Arg Ala Phe Thr Lys Ala Asn Glu Phe Ser Phe

450 455 460Gln Glu Glu Ala Glu Gln Asn Gln Arg Arg Gln Arg Lys Arg Pro Lys465 470 475 480Thr Asn Gln Arg Phe Gly Asn Lys Arg

485<210>559<211>492<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (469)<223>RXN03095<400>559aacgcctcaa ttagtgccag accttgccga ccgcagacca aacttcacca tttcaaacca 60tccctagcca caacaacggc agttgtgcaa tgatctgcgt atg aat gca gat aag 115

Met Asn Ala Asp Lys

1 5aaa atg tgc gga atg aac ccg gat agc caa tac gtc gaa ctt gcc gtc 163Lys Met Cys Gly Met Asn Pro Asp Ser Gln Tyr Val Glu Leu Ala Val

10 15 20gaa gtt ttc gga ctc ctc gcg gac gcc act cga gtt cgc atc atc ttg 211Glu Val Phe Gly Leu Leu Ala Asp Ala Thr Arg Val Arg Ile Ile Leu

25 30 35gca ctt cga aac agt ggt gaa ctt tcc gta aac cac ctc gcg gac atc 259Ala Leu Arg Asn Ser Gly Glu Leu Ser Val Asn His Leu Ala Asp Ile

40 45 50gtc gat aaatcc ccc gca gca gtt tcc caa cac ctc gcc cgg ctg cgc 307Val Asp Lys Ser Pro Ala Ala Val Ser Gln His Leu Ala Arg Leu Arg

55 60 65atg gcc cga atc gtg tcc acc cgt caa gaa ggt caa cga gtt ttc tac 355Met Ala Arg Ile Val Ser Thr Arg Gln Glu Gly Gln Arg Val Phe Tyr 70 75 80 85aaa ctc acc aat gaa cac gca tca cag cta gtc tcc gac gct att ttt 403Lys Leu Thr Asn Glu His Ala Ser Gln Leu Val Ser Asp Ala Ile Phe

90 95 100cag gcg gaa cac acc att gcg gac ggc cag act ccc cca cac cac cac 451Gln Ala Glu His Thr Ile Ala Asp Gly Gln Thr Pro Pro His His His

105 110 115cga gaa cga gaa caa tca tgaccaccca cagtcaccaa gaa 492Arg Glu Arg Glu Gln Ser

120<210>560<211>123<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>560Met Asn Ala Asp Lys Lys Met Cys Gly Met Asn Pro Asp Ser Gln Tyr 151015 Val Glu Leu Ala Val Glu Val Phe Gly Leu Leu Ala Asp Ala Thr Arg

20 25 30Val Arg Ile Ile Leu Ala Leu Arg Asn Ser Gly Glu Leu Ser Val Asn

35 40 45His Leu Ala Asp Ile Val Asp Lys Ser Pro Ala Ala Val Ser Gln His

50 55 60Leu Ala Arg Leu Arg Met Ala Arg Ile Val Ser Thr Arg Gln Glu Gly 65 70 75 80Gln Arg Val Phe Tyr Lys Leu Thr Asn Glu His Ala Ser Gln Leu Val

85 90 95Ser Asp Ala Ile Phe Gln Ala Glu His Thr Ile Ala Asp Gly Gln Thr

100 105110Pro Pro His His His Arg Glu Arg Glu Gln Ser

115120<210>561<211>591<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).<568<223>RXN03160<400>561gagcatatgg tgcgcgcggc cgatatgctg atcaattcca accccgatcc gcacgcttaa 60cttctgccaa aaagtcgttt tgaccataag ctaagcgatt gtg aat cga att gca 115

Val Asn Arg Ile Ala

1 5gaa atc gca cgc agt ttc ggc gtg ctg ggc ttc agc gct ttc ggc ggc 163Glu Ile Ala Arg Ser Phe Gly Val Leu Gly Phe Ser Ala Phe Gly Gly

10 15 20ccc acc gcg cac ctc gga tat ttc cgc acg gaa ttc gtg gag cgg cgg 211Pro Thr Ala His Leu Gly Tyr Phe Arg Thr Glu Phe Val Glu Arg Arg

25 30 35cgc tgg ctg gat gat cgc caa tat tcc gag atc gta gcg ctc agc caa 259Arg Trp Leu Asp Asp Arg Gln Tyr Ser Glu Ile Val Ala Leu Ser Gln

40 45 50cta ctt ccc gga cct gga tcg tcg cag gtc ggt atg atg ctg ggc tac 307Leu Leu Pro Gly Pro Gly Ser Ser Gln Val Gly Met Met Leu Gly Tyr

55 60 65cac cgc gcc ggt ttt tcc ggc atg gcg atc gcc tgg ctc atg ttt acc 355His Arg Ala Gly Phe Ser Gly Met Ala Ile Ala Trp Leu Met Phe Thr 70 75 80 85tgg ccc tca ttg gcg ctc atg gcg gcg ttc gcc ctg ctt ttt gat gcg 403Trp Pro Ser Leu Ala Leu Met Ala Ala Phe Ala Leu Leu Phe Asp Ala

90 95 100acc tcc gcc agc tgg acg ctc ggc ctg ctc gcc gca gcg gtc gcc gtc 451Thr Ser Ala Ser Trp Thr LeuGly Leu Leu Ala Ala Ala Val Ala Val

105 110 115gtt ttc aaa cgc agt cac cgg gca tgg cgc ggt tca atg gct tcc acg 499Val Phe Lys Arg Ser His Arg Ala Trp Arg Gly Ser Met Ala Ser Thr

120 125 130ccg ggg cgc cgg cca cca tcg ggg gtc ggc ctc ggg gca tcg cgg gtg 547Pro Gly Arg Arg Pro Pro Ser Gly Val Gly Leu Gly Ala Ser Arg Val

135140145 ctc ggc cct ccc caa cgg ggt taacacacct tggggttcaa tca 591Leu Gly Pro Pro Gln Arg Gly 150155<210>562<211>156<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>562Val Asn Arg Ile Ala Glu Ile Ala Arg Ser Phe Gly Val Leu Gly Phe 151015 Ser Ala Phe Gly Gly Pro Thr Ala His Leu Gly Tyr Phe Arg Thr Glu

20 25 30Phe Val Glu Arg Arg Arg Trp Leu Asp Asp Arg Gln Tyr Ser Glu Ile

35 40 45Val Ala Leu Ser Gln Leu Leu Pro Gly Pro Gly Ser Ser Gln Val Gly

50 55 60Met Met Leu Gly Tyr His Arg Ala Gly Phe Ser Gly Met Ala Ile Ala 65 70 75 80Trp Leu Met Phe Thr Trp Pro Ser Leu Ala Leu Met Ala Ala Phe Ala

85 90 95Leu Leu Phe Asp Ala Thr Ser Ala Ser Trp Thr Leu Gly Leu Leu Ala

100 105 110Ala Ala Val Ala Val Val Phe Lys Arg Ser His Arg Ala Trp Arg Gly

115 120 125Ser Met Ala Ser Thr Pro Gly Arg Arg Pro Pro Ser Gly Val Gly Leu

130135140 Gly Ala Ser Arg Val Leu Gly Pro Pro Gln Arg Gly145150155<210>563<211>645<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (622)<223>RXN02955<400>563atgcactggc tcccatcaaa gacgaattct tgacctcaga attccagcgt gaactctacg 60aagcagtgcg cgccgctgat acttcaggag gtgcggcatc atg atg aat ttt aag 115

Met Met Asn Phe Lys

1 5tcc atc gtg tgc gtc act gcc tgg cag gtg ttt agc cgc cag gtg ctg 163Ser Ile Val Cys Val Thr Ala Trp Gln Val Phe Ser Arg Gln Val Leu

10 15 20cac agc cca tca acg tgg tct gaa gaa cta tcc aag ctg ttg ttc gtg 211His Ser Pro Ser Thr Trp Ser Glu Glu Leu Ser Lys Leu Leu Phe Val

25 30 35tgg cta tct ttc gca ggt agt gcg ttc ctc ttt gga gag cgt gga cat 259Trp Leu Ser Phe Ala Gly Ser Ala Phe Leu Phe Gly Glu Arg Gly His

40 45 50att gcg gtt gat ttc atc gcg cgc aaa ctg cct gtt tct gcg cag cgg 307Ile Ala Val Asp Phe Ile Ala Arg Lys Leu Pro Val Ser Ala Gln Arg

55 60 65gtc ctg cag gtc att gtt cag ttg ttg att gtt gtt ttt gcg atc ctc 355Val Leu Gln Val Ile Val Gln Leu Leu Ile Val Val Phe Ala Ile Leu 70 75 80 85ggc atg atc tgg ggt ggc tac ttg gct gca tca atc gcg tgg aat cag 403Gly Met Ile Trp Gly Gly Tyr Leu Ala Ala Ser Ile Ala Trp Asn Gln

90 95 100cag ctc act gcg ctg cca ctt acc ttg gga tgg gtg tat gtt gtc atc 451Gln Leu Thr Ala Leu Pro Leu Thr Leu Gly Trp Val Tyr Val Val Ile

105 110115ccg atc gcg ggt gtg ttc atc gcg ttg ttc gcg atc atc gat ctc atc 499Pro Ile Ala Gly Val Phe Ile Ala Leu Phe Ala Ile Ile Asp Leu Ile

120 125 130gaa gtg gcc aca ggc aag gaa gag cct tac ccc ctt gtt gat gaa tca 547Glu Val Ala Thr Gly Lys Glu Glu Pro Tyr Pro Leu Val Asp Glu Ser

135 140 145gaa gaa cct cga gat ttg gac gag cta gag gcc caa agc gct ata gat 595Glu Glu Pro Arg Asp Leu Asp Glu Leu Glu Ala Gln Ser Ala Ile Asp150 155 160 165tct gca agt tca gcg gaa ggt agg aac taatatgttg tcgccagcag 642Ser Ala Ser Ser Ala Glu Gly Arg Asn

170ctg 645<210>564<211>174<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>564Met Met Asn Phe Lys Ser Ile Val Cys Val Thr Ala Trp Gln Val Phe 151015 Ser Arg Gln Val Leu His Ser Pro Ser Thr Trp Ser Glu Glu Leu Ser

20 25 30Lys Leu Leu Phe Val Trp Leu Ser Phe Ala Gly Ser Ala Phe Leu Phe

35 40 45Gly Glu Arg Gly His Ile Ala Val Asp Phe Ile Ala Arg Lys Leu Pro

50 55 60Val Ser Ala Gln Arg Val Leu Gln Val Ile Val Gln Leu Leu Ile Val 65 70 75 80Val Phe Ala Ile Leu Gly Met Ile Trp Gly Gly Tyr Leu Ala Ala Ser

85 90 95Ile Ala Trp Asn Gln Gln Leu Thr Ala Leu Pro Leu Thr Leu Gly Trp

100 105 110Val Tyr Val Val Ile Pro Ile Ala Gly Val Phe Ile Ala Leu Phe Ala

115 120 125Ile Ile AspLeu Ile Glu Val Ala Thr Gly Lys Glu Glu Pro Tyr Pro

130 135 140Leu Val Asp Glu Ser Glu Glu Pro Arg Asp Leu Asp Glu Leu Glu Ala145 150 155 160Gln Ser Ala Ile Asp Ser Ala Ser Ser Ala Glu Gly Arg Asn

165170<210>565<211>754<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (754)<223>RXN03109<400>565actggcgctt cccgatggtc aatcattggc ctttggtgcc caaactggcg agttgttgct 60ccgcgcatcc cgcgaactgt atgtgcaggg cggcgagtag atg gtt gtg aag gag 115

Met Val Val Lys Glu

1 5gtt gac gtc gaa aag caa aaa gct ggc cgg gtg cct ggt gct ata gct 163Val Asp Val Glu Lys Gln Lys Ala Gly Arg Val Pro Gly Ala Ile Ala

10 15 20aag cgt cgg acc gtg cgg att gtg ctg ttt gtc gcg ctg ggc gcg atc 211Lys Arg Arg Thr Val Arg Ile Val Leu Phe Val Ala Leu Gly Ala Ile

25 30 35gtg att gcg gcg tcg ctg tgg tcg att ctg gtc ggc caa tac acc atc 259Val Ile Ala Ala Ser Leu Trp Ser Ile Leu Val Gly Gln Tyr Thr Ile

40 45 50ccg att cgc gat cta cct gcg att tta gcc tcc ggt ccg acc ggt gcg 307Pro Ile Arg Asp Leu Pro Ala Ile Leu Ala Ser Gly Pro Thr Gly Ala

55 60 65cag acg atg gcg gaa caa gtc gtg tgg caa atc cgc atg ccg cgc atc 355Gln Thr Met Ala Glu Gln Val Val Trp Gln Ile Arg Met Pro Arg Ile 70 75 80 85gtg ctg gga ctg ctc gtg ggt gcc gct ttg ggc gtg gcc ggc gcg ctg 403Val Leu Gly Leu Leu Val Gly Ala Ala Leu Gly Val Ala Gly Ala Leu

90 95 100ttg cag gcg gtg ttt tcc aac ccg ctg gcg gaa ccg tcg atc atc ggc 451Leu Gln Ala Val Phe Ser Asn Pro Leu Ala Glu Pro Ser Ile Ile Gly

105 110 115gtg acc tcc ggc gcg ggc gtg ggt gct gct gcg gtg atc gtg ttt aac 499Val Thr Ser Gly Ala Gly Val Gly Ala Ala Ala Val Ile Val Phe Asn

120 125 130ctg aca ttt ttg ggc aca tcc acc gtc gca gtc ggc gcg ttt att acc 547Leu Thr Phe Leu Gly Thr Ser Thr Val Ala Val Gly Ala Phe Ile Thr

135 140 145gcg gtg atc acc acg att ttg gta tat cag ctg gcc aga agc cgt gga 595Ala Val Ile Thr Thr Ile Leu Val Tyr Gln Leu Ala Arg Ser Arg Gly150 155 160 165cgt gtg caa gtg atc aac ctg atc ctg aca ggc ata gcc att aat gca 643Arg Val Gln Val Ile Asn Leu Ile Leu Thr Gly Ile Ala Ile Asn Ala

170 175 180gta tcc ggc gcg ctg acc tca gtt ctt gat cta cat cgc gcc gac gag 691Val Ser Gly Ala Leu Thr Ser Val Leu Asp Leu His Arg Ala Asp Glu

185 190 195ctc ccg cga aga aat att ttc tgc aga tgg gtt cct cac ggc tcg cat 739Leu Pro Arg Arg Asn Ile Phe Cys Arg Trp Val Pro His Gly Ser His

200 205 210ggc gca cgt caa cgt 754Gly Ala Arg Gln Arg

215<210>566<211>218<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>566Met Val Val Lys Glu Val Asp Val Glu Lys Gln Lys Ala Gly Arg Val 151015 Pro GlyAla Ile Ala Lys Arg Arg Thr Val Arg Ile Val Leu Phe Val

20 25 30Ala Leu Gly Ala Ile Val Ile Ala Ala Ser Leu Trp Ser Ile Leu Val

35 40 45Gly Gln Tyr Thr Ile Pro Ile Arg Asp Leu Pro Ala Ile Leu Ala Ser

50 55 60Gly Pro Thr Gly Ala Gln Thr Met Ala Glu Gln Val Val Trp Gln Ile 65 70 75 80Arg Met Pro Arg Ile Val Leu Gly Leu Leu Val Gly Ala Ala Leu Gly

85 90 95Val Ala Gly Ala Leu Leu Gln Ala Val Phe Ser Asn Pro Leu Ala Glu

100 105 110Pro Ser Ile Ile Gly Val Thr Ser Gly Ala Gly Val Gly Ala Ala Ala

115 120 125Val Ile Val Phe Asn Leu Thr Phe Leu Gly Thr Ser Thr Val Ala Val

130 135 140Gly Ala Phe Ile Thr Ala Val Ile Thr Thr Ile Leu Val Tyr Gln Leu145 150 155 160Ala Arg Ser Arg Gly Arg Val Gln Val Ile Asn Leu Ile Leu Thr Gly

165 170 175Ile Ala Ile Asn Ala Val Ser Gly Ala Leu Thr Ser Val Leu Asp Leu

180 185 190His Arg Ala Asp Glu Leu Pro Arg Arg Asn Ile Phe Cys Arg Trp Val

195 200 205Pro His Gly Ser His Gly Ala Arg Gln Arg

210215<210>567<211>357<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (334)<223>RXN02979<400>567ctaggtcaag gaacttcact cggctagtcc ttagactcaa atgtgttcag acaaacactg 60gcaccgtaag gcacgaaagt taccgaaagg actggttccc atg acc gcc cca aac 115

Met Thr Ala Pro Asn

1 5act ctc aag caa aca act ctt cgc tct gat gag ttc tct tgc cca tcc 163Thr Leu Lys Gln Thr Thr Leu Arg Ser Asp Glu Phe Ser Cys Pro Ser

10 15 20tgt gtc tcc aag att gaa aac aaa ttg aat gga ttg gat ggc gtc gac 211Cys Val Ser Lys Ile Glu Asn Lys Leu Asn Gly Leu Asp Gly Val Asp

25 30 35aat gca gag gtg aag ttc tcc tcc gga aga atc ctt gtt gat cac gac 259Asn Ala Glu Val Lys Phe Ser Ser Gly Arg Ile Leu Val Asp His Asp

40 45 50ccc agc aag gtc tct atc aag gat cta gtc gct gca gtc gca gag gtt 307Pro Ser Lys Val Ser Ile Lys Asp Leu Val Ala Ala Val Ala Glu Val

556065 ggc tac acc gca aag cca tca gca atc taaaactctc agttagacca 354Gly Tyr Thr Ala Lys Pro Ser Ala Ile 7075 tta 357<210>568<211>78<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>568Met Thr Ala Pro Asn Thr Leu Lys Gln Thr Thr Leu Arg Ser Asp Glu 151015 Phe Ser Cys Pro Ser Cys Val Ser Lys Ile Glu Asn Lys Leu Asn Gly

20 25 30Leu Asp Gly Val Asp Asn Ala Glu Val Lys Phe Ser Ser Gly Arg Ile

35 40 45Leu Val Asp His Asp Pro Ser Lys Val Ser Ile Lys Asp Leu Val Ala

505560 Ala Val Ala Glu Val Gly Tyr Thr Ala Lys Pro Ser Ala Ile 657075<210>569<211>357<212>DNA<213>Corynebacteriumglutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (334)<223>RXN02987<400>569gttgtttgat ccaggtcaag gaattaaccc ggaaaggacc gtatctttaa aggtgcaagc 60acaggaacat gacgataaaa gatgaaagga cctggttacg atg acc gcc ccc gcc 115

Met Thr Ala Pro Ala

1 5acg ctg aag aac acc acc ttg cgc tct gat gag ttc acc tgt ccg agc 163Thr Leu Lys Asn Thr Thr Leu Arg Ser Asp Glu Phe Thr Cys Pro Ser

10 15 20tgt gtc gcc aag atc gaa aac aag ctg aat ggt ttg gac ggc gtg gag 211Cys Val Ala Lys Ile Glu Asn Lys Leu Asn Gly Leu Asp Gly Val Glu

25 30 35aat gcg gag gtg aag ttc tcc tcc gga cgc atc ctg atc acc cac gac 259Asn Ala Glu Val Lys Phe Ser Ser Gly Arg Ile Leu Ile Thr His Asp

40 45 50cca cag aag gtc tcc gta cgt gac ctg gtc acc gcg gta gcc gag gtc 307Pro Gln Lys Val Ser Val Arg Asp Leu Val Thr Ala Val Ala Glu Val

556065 ggt tac acc gcc aag ccg tcg gcg atc tgacgcactc ccgaccccac 354Gly Tyr Thr Ala Lys Pro Ser Ala Ile 7075 aag 357<210>570<211>78<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>570Met Thr Ala Pro Ala Thr Leu Lys Asn Thr Thr Leu Arg Ser Asp Glu 151015 Phe Thr Cys Pro Ser Cys Val Ala Lys Ile Glu Asn Lys Leu Asn Gly

20 25 30Leu Asp Gly Val Glu Asn Ala Glu Val Lys Phe Ser Ser Gly Arg Ile

35 40 45Leu Ile Thr His Asp Pro Gln Lys Val Ser Val Arg Asp Leu Val Thr

505560 Ala Val AlaGlu Val Gly Tyr Thr Ala Lys Pro Ser Ala Ile 657075<210>571<211>1041<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1018)<223>RXN03084<400>571ccacccccac gtctaagttt tcccctattt acacacacct gaccgaagct gtaaggtttg 60cctaatcttt ttcaatctaa agtcaggata ttcacagccc atg tca tct cgc aga 115

Met Ser Ser Arg Arg

1 5aaa ctc tcc tcc gca ctg atc gtg ctt ctc gca gca gca cta cct ctt 163Lys Leu Ser Ser Ala Leu Ile Val Leu Leu Ala Ala Ala Leu Pro Leu

10 15 20act gct tgt tcc tcc agc tca gaa gag gaa gca tcc acc agc tct gcg 211Thr Ala Cys Ser Ser Ser Ser Glu Glu Glu Ala Ser Thr Ser Ser Ala

25 30 35act cgc gaa ttc aca gac gct cac gga aca acc gaa gtt ccc gaa aat 259Thr Arg Glu Phe Thr Asp Ala His Gly Thr Thr Glu Val Pro Glu Asn

40 45 50cct cag cgc gtc gtt gtc ctc gag cca ctt gag cta gac acc gca atc 307Pro Gln Arg Val Val Val Leu Glu Pro Leu Glu Leu Asp Thr Ala Ile

55 60 65gcc ctc gga atc acc cca gtg ggt gca gct gtc gcc aac aac gtc act 355Ala Leu Gly Ile Thr Pro Val Gly Ala Ala Val Ala Asn Asn Val Thr 70 75 80 85ggt att cct gca tat ctc ggc gtc gat gga atc gag cct gtc ggc acc 403Gly Ile Pro Ala Tyr Leu Gly Val Asp Gly Ile Glu Pro Val Gly Thr

90 95 100gtt tct gag cca aat atc gaa gcg atc gct gct ctc gag ccc gac ctg 451Val Ser Glu Pro Asn Ile Glu Ala Ile Ala Ala Leu Glu Pro Asp Leu

105 110 115atc ctg ggc acc gat tcc cgc cac gcc gaa atc tac gac cgc ctc gaa 499Ile Leu Gly Thr Asp Ser Arg His Ala Glu Ile Tyr Asp Arg Leu Glu

120 125 130tcc atc gcc cca acc gtg ttc atg aca acc cat gtt gat ccg tgg aaa 547Ser Ile Ala Pro Thr Val Phe Met Thr Thr His Val Asp Pro Trp Lys

135 140 145gac aat gtc gtc ttc atc ggc gat gca ttg ggc aag aag cag gaa tcc 595Asp Asn Val Val Phe Ile Gly Asp Ala Leu Gly Lys Lys Gln Glu Ser150 155 160 165gag gat ctc atc caa ggc ttt aat gac aag tgc gaa gag atc aag tcc 643Glu Asp Leu Ile Gln Gly Phe Asn Asp Lys Cys Glu Glu Ile Lys Ser

170 175 180gag cat gat gtc gaa ggt aag acc gtc aac atg att cgt ccc cgc gac 691Glu His Asp Val Glu Gly Lys Thr Val Asn Met Ile Arg Pro Arg Asp

185 190 195gag caa acc atg agc cta tac ggc ccg acc tca ttt gcc ggc agc tct 739Glu Gln Thr Met Ser Leu Tyr Gly Pro Thr Ser Phe Ala Gly Ser Ser

200 205 210ttg gag tgc gca gga ctc acc att cct gat cag gaa tgg aag gat gac 787Leu Glu Cys Ala Gly Leu Thr Ile Pro Asp Gln Glu Trp Lys Asp Asp

215 220 225ctc cag gcc gac atc gct cct gag aac ttc atg ctc gcc acc gcc gac 835Leu Gln Ala Asp Ile Ala Pro Glu Asn Phe Met Leu Ala Thr Ala Asp230 235 240 245tac gtc ttt gtc acc gca act gat gtc acc gat gaa aat gag ctc ccc 883Tyr Val Phe Val Thr Ala Thr Asp Val Thr Asp Glu Asn Glu Leu Pro

250 255 260gaa gta atc cga gaa aac cgc gaa cag ttc cca tca ctc acc ctt gtc 931Glu Val Ile Arg Glu Asn Arg Glu Gln Phe Pro Ser Leu Thr Leu Val

265 270 275gat acc agc tac tgg gta tct ggc gtc ggt cca ctt ggc ggc agc aaa 979Asp Thr Ser Tyr Trp Val Ser Gly Val Gly Pro Leu Gly Gly Ser Lys

280 285 290gtc ttg gaa gac atc gat gcc ttc ctc gac gca cag caa taatgtccac 1028Val Leu Glu Asp Ile Asp Ala Phe Leu Asp Ala Gln Gln

295300305 agctctcccc gat 1041<210>572<211>306<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>572Met Ser Ser Arg Arg Lys Leu Ser Ser Ala Leu Ile Val Leu Leu Ala 151015 Ala Ala Leu Pro Leu Thr Ala Cys Ser Ser Ser Ser Glu Glu Glu Ala

20 25 30Ser Thr Ser Ser Ala Thr Arg Glu Phe Thr Asp Ala His Gly Thr Thr

35 40 45Glu Val Pro Glu Asn Pro Gln Arg Val Val Val Leu Glu Pro Leu Glu

50 55 60Leu Asp Thr Ala Ile Ala Leu Gly Ile Thr Pro Val Gly Ala Ala Val 65 70 75 80Ala Asn Asn Val Thr Gly Ile Pro Ala Tyr Leu Gly Val Asp Gly Ile

85 90 95Glu Pro Val Gly Thr Val Ser Glu Pro Asn Ile Glu Ala Ile Ala Ala

100 105 110Leu Glu Pro Asp Leu Ile Leu Gly Thr Asp Ser Arg His Ala Glu Ile

115 120 125Tyr Asp Arg Leu Glu Ser Ile Ala Pro Thr Val Phe Met Thr Thr His

130 135 140Val Asp Pro Trp Lys Asp Asn Val Val Phe Ile Gly Asp Ala Leu Gly145150 155 160Lys Lys Gln Glu Ser Glu Asp Leu Ile Gln Gly Phe Asn Asp Lys Cys

165 170 175Glu Glu Ile Lys Ser Glu His Asp Val Glu Gly Lys Thr Val Asn Met

180 185 190Ile Arg Pro Arg Asp Glu Gln Thr Met Ser Leu Tyr Gly Pro Thr Ser

195 200 205Phe Ala Gly Ser Ser Leu Glu Cys Ala Gly Leu Thr Ile Pro Asp Gln

210 215 220Glu Trp Lys Asp Asp Leu Gln Ala Asp Ile Ala Pro Glu Asn Phe Met225 230 235 240Leu Ala Thr Ala Asp Tyr Val Phe Val Thr Ala Thr Asp Val Thr Asp

245 250 255Glu Asn Glu Leu Pro Glu Val Ile Arg Glu Asn Arg Glu Gln Phe Pro

260 265 270Ser Leu Thr Leu Val Asp Thr Ser Tyr Trp Val Ser Gly Val Gly Pro

275 280 285Leu Gly Gly Ser Lys Val Leu Glu Asp Ile Asp Ala Phe Leu Asp Ala

290295300 Gln Gln305<210>573<211>440<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1).)

20 25 30aac gtc aac tcc gaa aac aag gca acc gcc cgc gac ttc atc gaa ttc 144Asn Val Asn Ser Glu Asn Lys Ala Thr Ala Arg Asp Phe Ile Glu Phe

35 40 45atc atc aac gaa gag aac caa acc tgg ttc gcg gac aac tcc ttc cca 192Ile Ile Asn Glu Glu Asn Gln Thr Trp Phe Ala Asp Asn Ser Phe Pro

50 5560cca gtt ctg gca tcc atc tac gat gat gag tcc ctt gtt gag cag tac 240Pro Val Leu Ala Ser Ile Tyr Asp Asp Glu Ser Leu Val Glu Gln Tyr 65 70 75 80cca tac ctg cca gca ctg aag gaa tcc ctg gaa aac gca gca cca cgc 288Pro Tyr Leu Pro Ala Leu Lys Glu Ser Leu Glu Asn Ala Ala Pro Arg

85 90 95cca gtg tct cct ttc tac cca gcc atc tcc aag gca atc cag gac aac 336Pro Val Ser Pro Phe Tyr Pro Ala Ile Ser Lys Ala Ile Gln Asp Asn

100 105 110gcc tac gca gcg ctt aac ggc aac gtc gac gtt gac cag gca acc acc 384Ala Tyr Ala Ala Leu Asn Gly Asn Val Asp Val Asp Gln Ala Thr Thr

115 120 125gat atg aag gca gcg atc gaa aac gct tcc agc tagttcggta atttagttca 437Asp Met Lys Ala Ala Ile Glu Asn Ala Ser Ser

130135 ttc 440<210>574<211>139<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>574Glu Ala Glu Ala Thr Ala Gly Lys Phe Glu Val Gln Pro Leu Val Gly 151015 Lys Asp Gly Val Gly Val Ser Thr Leu Gly Gly Tyr Asn Asn Gly Ile

20 25 30Asn Val Asn Ser Glu Asn Lys Ala Thr Ala Arg Asp Phe Ile Glu Phe

35 40 45Ile Ile Asn Glu Glu Asn Gln Thr Trp Phe Ala Asp Asn Ser Phe Pro

50 55 60Pro Val Leu Ala Ser Ile Tyr Asp Asp Glu Ser Leu Val Glu Gln Tyr 65 70 75 80Pro Tyr Leu Pro Ala Leu Lys Glu Ser Leu Glu Asn Ala Ala Pro Arg

85 90 95Pro Val Ser Pro Phe Tyr Pro Ala Ile Ser Lys Ala Ile Gln Asp Asn

100 105 110Ala Tyr Ala Ala Leu Asn Gly Asn Val Asp Val Asp Gln Ala Thr Thr

115 120 125Asp Met Lys Ala Ala Ile Glu Asn Ala Ser Ser

130135<210>575<211>1077<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1054)<223>RXN01139<400>575accaccgtgg caggcttttt cagtggcaag aagattaatt ctccacccct tcattttcaa 60taagctttca ataaggggag aagtgtgctt agctggggtc atg gaa agc cac gat 115

Met Glu Ser His Asp

1 5ctt cag cag cgc agt tat gcg cac aat ccc gat ggc cac gac cac agc 163Leu Gln Gln Arg Ser Tyr Ala His Asn Pro Asp Gly His Asp His Ser

10 15 20cat gac gga ctc gga cac tca cat gct ccc agc tcc ctc aag gct ctt 211His Asp Gly Leu Gly His Ser His Ala Pro Ser Ser Leu Lys Ala Leu

25 30 35ttt gcg gtc atc att ttc acc tcg atc atc ttc cta gcg gaa cta atc 259Phe Ala Val Ile Ile Phe Thr Ser Ile Ile Phe Leu Ala Glu Leu Ile

40 45 50gcc ggc ctt att tcc gga tct ttg gca ctg ctg gct gac gcc atg cac 307Ala Gly Leu Ile Ser Gly Ser Leu Ala Leu Leu Ala Asp Ala Met His

55 60 65atg ctg tcc gac tcc act ggc ttg atc att gcg gct gtc gcc atg ctc 355Met Leu Ser Asp Ser Thr Gly Leu Ile Ile Ala Ala Val Ala Met Leu 70 75 80 85att ggc cgt cgg gca cgc act tct cgt gcg acc tac gga tac aag cgt 403Ile Gly Arg Arg Ala Arg Thr Ser Arg Ala Thr Tyr Gly Tyr Lys Arg

90 95 100gcg gaa gtc ttg gca gcg atg gtt aac gcc acc gtt gtt aca gca ctg 451Ala Glu Val Leu Ala Ala Met Val Asn Ala Thr Val Val Thr Ala Leu

105 110 115tct gtg tgg atc gtc gtt gag gcc atc atg cgt ctg ggc aag gac ctg 499Ser Val Trp Ile Val Val Glu Ala Ile Met Arg Leu Gly Lys Asp Leu

120 125 130gaa atc cag acc aac ctg atg ctc atc gtc gcg gtc att ggt ttt gtc 547Glu Ile Gln Thr Asn Leu Met Leu Ile Val Ala Val Ile Gly Phe Val

135 140 145acc aac gga att tcc gcc ctg gtg ttg atg cgc cac caa gat ggc aat 595Thr Asn Gly Ile Ser Ala Leu Val Leu Met Arg His Gln Asp Gly Asn150 155 160 165atc aat atg cgt gga gca ttc ctt cac gtt ctc agt gac atg ctg ggt 643Ile Asn Met Arg Gly Ala Phe Leu His Val Leu Ser Asp Met Leu Gly

170 175 180tcc gtt gcc gtc att att gcg ggc ctg gtg att cgc tac acg gga tgg 691Ser Val Ala Val Ile Ile Ala Gly Leu Val Ile Arg Tyr Thr Gly Trp

185 190 195atg ccg gcc gat acc att gct tcg att gcg att gct gcg att att att 739Met Pro Ala Asp Thr Ile Ala Ser Ile Ala Ile Ala Ala Ile Ile Ile

200 205 210cct cgc gca ttc agc ctc ctg aag gaa gct ctc aat atc ttg ttg gag 787Pro Arg Ala Phe Ser Leu Leu Lys Glu Ala Leu Asn Ile Leu Leu Glu

215 220 225cgt gtt cct aca ggt gcg gag cct gca gag gtc gac gca gcc ctt cgt 835Arg Val Pro Thr Gly Ala Glu Pro Ala Glu Val Asp Ala Ala Leu Arg230 235 240 245aaa gtc cca ggt gtc agc gat gtg cat gat ctt cac att tgg agc att 883Lys Val Pro Gly Val Ser Asp Val His Asp Leu His Ile Trp Ser Ile

250 255 260gac ggc aag gaa atc ctg gcc acg gtg cat ttg gtg gtg gat tcg tct 931Asp Gly Lys Glu Ile Leu Ala Thr Val His Leu Val Val Asp Ser Ser

265 270 275aca aat cag ctg cat agt tgt ggc gtg ttg gat cgg gca gaa gcg gaa 979Thr Asn Gln Leu His Ser Cys Gly Val Leu Asp Arg Ala Glu Ala Glu

280 285 290cta tcc aaa ctt ggg atc ttg cac tca aca att cag ctg gaa agc gca 1027Leu Ser Lys Leu Gly Ile Leu His Ser Thr Ile Gln Leu Glu Ser Ala

295300305 gat cac agt gat cat gaa agt gtg tgc tgatatagag tatgtcccat 1074Asp His Ser Asp His Glu Ser Val Cys 310315 ggg1077<210>576<211>318<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>576Met Glu Ser His Asp Leu Gln Gln Arg Ser Tyr Ala His Asn Pro Asp 151015 Gly His Asp His Ser His Asp Gly Leu Gly His Ser His Ala Pro Ser

20 25 30Ser Leu Lys Ala Leu Phe Ala Val Ile Ile Phe Thr Ser Ile Ile Phe

35 40 45Leu Ala Glu Leu Ile Ala Gly Leu Ile Ser Gly Ser Leu Ala Leu Leu

50 55 60Ala Asp Ala Met His Met Leu Ser Asp Ser Thr Gly Leu Ile Ile Ala 65 70 75 80Ala Val Ala Met Leu Ile Gly Arg Arg Ala Arg Thr Ser Arg Ala Thr

85 90 95Tyr Gly Tyr Lys Arg Ala Glu Val Leu Ala Ala Met Val Asn Ala Thr

100 105110Val Val Thr Ala Leu Ser Val Trp Ile Val Val Glu Ala Ile Met Arg

115 120 125Leu Gly Lys Asp Leu Glu Ile Gln Thr Asn Leu Met Leu Ile Val Ala

130 135 140Val Ile Gly Phe Val Thr Asn Gly Ile Ser Ala Leu Val Leu Met Arg145 150 155 160His Gln Asp Gly Asn Ile Asn Met Arg Gly Ala Phe Leu His Val Leu

165 170 175Ser Asp Met Leu Gly Ser Val Ala Val Ile Ile Ala Gly Leu Val Ile

180 185 190Arg Tyr Thr Gly Trp Met Pro Ala Asp Thr Ile Ala Ser Ile Ala Ile

195 200 205Ala Ala Ile Ile Ile Pro Arg Ala Phe Ser Leu Leu Lys Glu Ala Leu

210 215 220Asn Ile Leu Leu Glu Arg Val Pro Thr Gly Ala Glu Pro Ala Glu Val225 230 235 240Asp Ala Ala Leu Arg Lys Val Pro Gly Val Ser Asp Val His Asp Leu

245 250 255His Ile Trp Ser Ile Asp Gly Lys Glu Ile Leu Ala Thr Val His Leu

260 265 270Val Val Asp Ser Ser Thr Asn Gln Leu His Ser Cys Gly Val Leu Asp

275 280 285Arg Ala Glu Ala Glu Leu Ser Lys Leu Gly Ile Leu His Ser Thr Ile

290295300 Gln Leu Glu Ser Ala Asp His Ser Asp His Glu Ser Val Cys 305310315<210>577<211>2733<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (2710)<223>RXN00378<400>577accgtgagcc ttatactgtg aggacattaa aagtgacacc tctttttcta tcttttacaa 60cccaagaagg tttatcgtga gcacaccgga ttcttcctcg gtg gac aag gcc gta 115

Val Asp Lys Ala Val

1 5aac act gct atc tct gac gcc aaa aca gcg gcg ctc aag gca ggt gtt 163Asn Thr Ala Ile Ser Asp Ala Lys Thr Ala Ala Leu Lys Ala Gly Val

10 15 20gga ttg aac cga gcc acc gcc tca gaa gaa gag gaa gat tta agc tca 211Gly Leu Asn Arg Ala Thr Ala Ser Glu Glu Glu Glu Asp Leu Ser Ser

25 30 35agc att aag gtt tct ttg gcc ttt gag ctc gag ggg tta agc aat gca 259Ser Ile Lys Val Ser Leu Ala Phe Glu Leu Glu Gly Leu Ser Asn Ala

40 45 50cca tcg ttg atg gtg gtg gaa aaa gcc cta gag aag atc ccc ggt gta 307Pro Ser Leu Met Val Val Glu Lys Ala Leu Glu Lys Ile Pro Gly Val

55 60 65tcc gcg gat ctg att tac cct tca caa act gca tgg att aca gca act 355Ser Ala Asp Leu Ile Tyr Pro Ser Gln Thr Ala Trp Ile Thr Ala Thr 70 75 80 85gat cgg gta cat ccc gaa acc ctc att gag gtg ttt gag cag ttc ggc 403Asp Arg Val His Pro Glu Thr Leu Ile Glu Val Phe Glu Gln Phe Gly

90 95 100atc aaa gca cac ctt tct aat tca tcg ctg ctg cgc agg cat caa cag 451Ile Lys Ala His Leu Ser Asn Ser Ser Leu Leu Arg Arg His Gln Gln

105 110 115ctc agc gcg gaa gta aat agg gaa gca cgc ctt gat cgt tac cgc tcc 499Leu Ser Ala Glu Val Asn Arg Glu Ala Arg Leu Asp Arg Tyr Arg Ser

120 125130cga atg gat gcc aag cga atc tcg cct cgt gtg cga agg cat aac cga 547Arg Met Asp Ala Lys Arg Ile Ser Pro Arg Val Arg Arg His Asn Arg

135 140 145caa gaa atg gta cat gcg gta cgc gct cgt gaa agt ggt tgg att aaa 595Gln Glu Met Val His Ala Val Arg Ala Arg Glu Ser Gly Trp Ile Lys150 155 160 165cgc agg aat cac acc acc tcg cag cat gaa gac cca atg tcg ggc gat 643Arg Arg Asn His Thr Thr Ser Gln His Glu Asp Pro Met Ser Gly Asp

170 175 180gtg ctg ttc acc gcc cgc gca ctg att aca cct aag cgt ttg tgg gtg 691Val Leu Phe Thr Ala Arg Ala Leu Ile Thr Pro Lys Arg Leu Trp Val

185 190 195tcg ttg ccg ttt gcg ctc atc gta ttg gcg tta tcg ttg aat cct tcg 739Ser Leu Pro Phe Ala Leu Ile Val Leu Ala Leu Ser Leu Asn Pro Ser

200 205 210tgg cag ttt gat tat tgg cag tgg ttg tcc gct gtg ttg gct att cct 787Trp Gln Phe Asp Tyr Trp Gln Trp Leu Ser Ala Val Leu Ala Ile Pro

215 220 225gtg gtg gtg tgg ggt gcc tgg ccg ttt cac cgc gct gca gca ggc ggt 835Val Val Val Trp Gly Ala Trp Pro Phe His Arg Ala Ala Ala Gly Gly230 235 240 245att cgt cga gga att tcc gct ctt gat gcg acc agc tca atc gct att 883Ile Arg Arg Gly Ile Ser Ala Leu Asp Ala Thr Ser Ser Ile Ala Ile

250 255 260gct gct gca tac gcg tgg tct atc gcc atg ctg ttg ttt gaa acc cca 931Ala Ala Ala Tyr Ala Trp Ser Ile Ala Met Leu Leu Phe Glu Thr Pro

265 270 275gga ggt aaa tcc tgg cgg tca tat ccg tcc tgg ttc gct ttt gac cac 979Gly Gly Lys Ser Trp Arg Ser Tyr Pro Ser Trp Phe Ala Phe Asp His

280 285 290ggc acg ttg acc caa aac gag att tat ttt gat gtg gcc tgc gga atc 1027Gly Thr Leu Thr Gln Asn Glu Ile Tyr Phe Asp Val Ala Cys Gly Ile

295 300 305acc gtg ttg ctt ctt gcc gga cgg ctg ctg aca agg cgt cga agc caa 1075Thr Val Leu Leu Leu Ala Gly Arg Leu Leu Thr Arg Arg Arg Ser Gln310 315 320 325tcc agt ttg tta gcg gaa ctt ggt cgc ctc caa atc gat cca cag cgc 1123Ser Ser Leu Leu Ala Glu Leu Gly Arg Leu Gln Ile Asp Pro Gln Arg

330 335 340att gtc act gtg gtg cgt aaa cac cga ttg aag cgc gta gtc cag gaa 1171Ile Val Thr Val Val Arg Lys His Arg Leu Lys Arg Val Val Gln Glu

345 350 355ctg aac att cca gtg cag gaa gtc cgt gtc aat gac gat gtg aaa gtt 1219Leu Asn Ile Pro Val Gln Glu Val Arg Val Asn Asp Asp Val Lys Val

360 365 370cca cct aat acc acg atc cct gtg gat ggc act gtc atc ggt ggc ggt 1267Pro Pro Asn Thr Thr Ile Pro Val Asp Gly Thr Val Ile Gly Gly Gly

375 380 385tcg cgg atc gca gct agc atc atc atg gga caa gac cag cgt gat gta 1315Ser Arg Ile Ala Ala Ser Ile Ile Met Gly Gln Asp Gln Arg Asp Val390 395 400 405aaa gta aat gac aaa gtt ttc gcc ggc agc ctc aac ctc gaa tcc gaa 1363Lys Val Asn Asp Lys Val Phe Ala Gly Ser Leu Asn Leu Glu Ser Glu

410 415 420atc aag gtt cgt gtt att cgc act ggt cac cgc acc cgc atc gcc gcg 1411Ile Lys Val Arg Val Ile Arg Thr Gly His Arg Thr Arg Ile Ala Ala

425 430435gta cat agg tgg gtt aaa gaa gcg acg ttg aag gaa aac cgc cac aat 1459Val His Arg Trp Val Lys Glu Ala Thr Leu Lys Glu Asn Arg His Asn

440 445 450agg gca gcg atc cgt tcg gcc ggt aac ctt gtg ccc atc acg ttc acc 1507Arg Ala Ala Ile Arg Ser Ala Gly Asn Leu Val Pro Ile Thr Phe Thr

455 460 465ctt gct gtg gtg gac ttc tgt ctg tgg gca ctg atc tct gga aac atc 1555Leu Ala Val Val Asp Phe Cys Leu Trp Ala Leu Ile Ser Gly Asn Ile470 475 480 485aac gct gca ttt acc act acc ttg gct gtc ctt gcg tgc gtg gct ccg 1603Asn Ala Ala Phe Thr Thr Thr Leu Ala Val Leu Ala Cys Val Ala Pro

490 495 500gtg gcc tta gcg ttg tct gct cca ctt gcc acg agg aat tcc atc gaa 1651Val Ala Leu Ala Leu Ser Ala Pro Leu Ala Thr Arg Asn Ser Ile Glu

505 510 515gct gca gca cga cac ggt att ttg gtc cgc tct ggt gaa att ttc cga 1699Ala Ala Ala Arg His Gly Ile Leu Val Arg Ser Gly Glu Ile Phe Arg

520 525 530gtt ctc gat gat gtg gat act gcc gta ttt aat cgt gtg ggc aca cta 1747Val Leu Asp Asp Val Asp Thr Ala Val Phe Asn Arg Val Gly Thr Leu

535 540 545acc gat ggc gaa atg aca gtg gaa acc gtc aca gca gac aaa ggc gag 1795Thr Asp Gly Glu Met Thr Val Glu Thr Val Thr Ala Asp Lys Gly Glu550 555 560 565gac cca gaa cta gtg ctg cgt gtc gcc ggg gcg ttg gcc atg gaa tcc 1843Asp Pro Glu Leu Val Leu Arg Val Ala Gly Ala Leu Ala Met Glu Ser

570 575 580cac cac gcg att tcc aaa gca ctg gtg aaa gca tcc cgt gaa gct cgt 1891His His Ala Ile Ser Lys Ala Leu Val Lys Ala Ser Arg Glu Ala Arg

585 590 595gat acc ggc gcc ggt ggt gaa gat gtc cca cac tgg att gaa gta ggc 1939Asp Thr Gly Ala Gly Gly Glu Asp Val Pro His Trp Ile Glu Val Gly

600 605 610aac gtg gaa ate acc gaa gcc ggc tca ttc caa gca acc atc gag ctg 1987Asn Val Glu Ile Thr Glu Ala Gly Ser Phe Gln Ala Thr Ile Glu Leu

615 620 625cca ctg atc aaa cca tct ggc gaa aaa atc atg cgc acc aca gaa gca 2035Pro Leu Ile Lys Pro Ser Gly Glu Lys Ile Met Arg Thr Thr Glu Ala630 635 640 645ctc ctg tgg cga cca cga tcc atg aca gaa gtc cgt gag cac tta agc 2083Leu Leu Trp Arg Pro Arg Ser Met Thr Glu Val Arg Glu His Leu Ser

650 655 660ccc cga cta gtg gca gca gca acc tca ggt ggc gca cca ctg atc gtg 2131Pro Arg Leu Val Ala Ala Ala Thr Ser Gly Gly Ala Pro Leu Ile Val

665 670 675cga tgg aaa ggc aaa gac cgc gga gtt atc act cta agt gac cac gtg 2179Arg Trp Lys Gly Lys Asp Arg Gly Val Ile Thr Leu Ser Asp His Val

680 685 690aga tca gat tcc tcc gat gcg att att gcg att gaa gaa caa ggc atc 2227Arg Ser Asp Ser Ser Asp Ala Ile Ile Ala Ile Glu Glu Gln Gly Ile

695 700 705gag acc atg atg ctt tca cgt gat act tac ccg gtg gca cgt cga tac 2275Glu Thr Met Met Leu Ser Arg Asp Thr Tyr Pro Val Ala Arg Arg Tyr710 715 720 725gca gac agc tta ggc atc acc cac gtc ttg gcc ggc atc gcg ccg ggc 2323Ala Asp Ser Leu Gly Ile Thr His Val Leu Ala Gly Ile Ala Pro Gly

730 735 740aag aaa gcc cag gtc gtc cgt gca gtc cac acc cgc gga tcc act gtc 2371Lys Lys Ala Gln Val Val Arg Ala Val His Thr Arg Gly Ser Thr Val

745 750 755gcg atg atc ggc gat gaa tca gta atg gac tgt ttg aaa gtc gct gac 2419Ala Met Ile Gly Asp Glu Ser Val Met Asp Cys Leu Lys Val Ala Asp

760 765 770gtg ggt gta ctg atg ggc gtc gat cgt ccc tca gat ctg cgt gat gat 2467Val Gly Val Leu Met Gly Val Asp Arg Pro Ser Asp Leu Arg Asp Asp

775 780 785tcc gat gac ccg gca gct gac gtt gtg gtc atg cgc gaa gag gtc atg 2515Ser Asp Asp Pro Ala Ala Asp Val Val Val Met Arg Glu Glu Val Met790 795 800 805agc gtg ccg acg ctg ttt aaa ctg gct cga cgc tac gcc aag ttg gtc 2563Ser Val Pro Thr Leu Phe Lys Leu Ala Arg Arg Tyr Ala Lys Leu Val

810 815 820aat ggc aat att gct ctg gcc tgg atc tat aac ggt gtt gcc atg gtg 2611Asn Gly Asn Ile Ala Leu Ala Trp Ile Tyr Asn Gly Val Ala Met Val

825 830 835ctt gca gtg tct ggc ttg ctg cat cca atg gct gcg acc gtg gct atg 2659Leu Ala Val Ser Gly Leu Leu His Pro Met Ala Ala Thr Val Ala Met

840 845 850ctg gcg tct tcg ctg ctt att gaa tgg cgc tcg ggc agg gcg cgc aag 2707Leu Ala Ser Ser Leu Leu Ile Glu Trp Arg Ser Gly Arg Ala Arg Lys

855860865 tac taaccagcaa ttcccaagcc caa 2733Tyr870<210>578<211>870<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>578Val Asp Lys Ala Val Asn Thr Ala Ile Ser Asp Ala Lys Thr Ala Ala 151015 Leu Lys Ala Gly Val GlyLeu Asn Arg Ala Thr Ala Ser Glu Glu Glu

20 25 30Glu Asp Leu Ser Ser Ser Ile Lys Val Ser Leu Ala Phe Glu Leu Glu

35 40 45Gly Leu Ser Asn Ala Pro Ser Leu Met Val Val Glu Lys Ala Leu Glu

50 55 60Lys Ile Pro Gly Val Ser Ala Asp Leu Ile Tyr Pro Ser Gln Thr Ala 65 70 75 80Trp Ile Thr Ala Thr Asp Arg Val His Pro Glu Thr Leu Ile Glu Val

85 90 95Phe Glu Gln Phe Gly Ile Lys Ala His Leu Ser Asn Ser Ser Leu Leu

100 105 110Arg Arg His Gln Gln Leu Ser Ala Glu Val Asn Arg Glu Ala Arg Leu

115 120 125Asp Arg Tyr Arg Ser Arg Met Asp Ala Lys Arg Ile Ser Pro Arg Val

130 135 140Arg Arg His Asn Arg Gln Glu Met Val His Ala Val Arg Ala Arg Glu145 150 155 160Ser Gly Trp Ile Lys Arg Arg Asn His Thr Thr Ser Gln His Glu Asp

165 170 175Pro Met Ser Gly Asp Val Leu Phe Thr Ala Arg Ala Leu Ile Thr Pro

180 185 190Lys Arg Leu Trp Val Ser Leu Pro Phe Ala Leu Ile Val Leu Ala Leu

195 200 205Ser Leu Asn Pro Ser Trp Gln Phe Asp Tyr Trp Gln Trp Leu Ser Ala

210 215 220Val Leu Ala Ile Pro Val Val Val Trp Gly Ala Trp Pro Phe His Arg225 230 235 240Ala Ala Ala Gly Gly Ile Arg Arg Gly Ile Ser Ala Leu Asp Ala Thr

245 250 255Ser Ser Ile Ala Ile Ala Ala Ala Tyr Ala Trp Ser Ile Ala Met Leu

260 265 270Leu Phe Glu Thr Pro Gly Gly Lys Ser Trp Arg Ser Tyr Pro Ser Trp

275 280 285Phe Ala Phe Asp His Gly Thr Leu Thr Gln Asn Glu Ile Tyr Phe Asp

290 295 300Val Ala Cys Gly Ile Thr Val Leu Leu Leu Ala Gly Arg Leu Leu Thr305 310 315 320Arg Arg Arg Ser Gln Ser Ser Leu Leu Ala Glu Leu Gly Arg Leu Gln

325 330 335Ile Asp Pro Gln Arg Ile Val Thr Val Val Arg Lys His Arg Leu Lys

340 345 350Arg Val Val Gln Glu Leu Asn Ile Pro Val Gln Glu Val Arg Val Asn

355 360 365Asp Asp Val Lys Val Pro Pro Asn Thr Thr Ile Pro Val Asp Gly Thr

370 375 380Val Ile Gly Gly Gly Ser Arg Ile Ala Ala Ser Ile Ile Met Gly Gln385 390 395 400Asp Gln Arg Asp Val Lys Val Asn Asp Lys Val Phe Ala Gly Ser Leu

405 410 415Asn Leu Glu Ser Glu Ile Lys Val Arg Val Ile Arg Thr Gly His Arg

420 425 430Thr Arg Ile Ala Ala Val His Arg Trp Val Lys Glu Ala Thr Leu Lys

435 440 445Glu Asn Arg His Asn Arg Ala Ala Ile Arg Ser Ala Gly Asn Leu Val

450 455 460Pro Ile Thr Phe ThrLeu Ala Val Val Asp Phe Cys Leu Trp Ala Leu465 470 475 480Ile Ser Gly Asn Ile Asn Ala Ala Phe Thr Thr Thr Leu Ala Val Leu

485 490 495Ala Cys Val Ala Pro Val Ala Leu Ala Leu Ser Ala Pro Leu Ala Thr

500 505 510Arg Asn Ser Ile Glu Ala Ala Ala Arg His Gly Ile Leu Val Arg Ser

515 520 525Gly Glu Ile Phe Arg Val Leu Asp Asp Val Asp Thr Ala Val Phe Asn

530 535 540Arg Val Gly Thr Leu Thr Asp Gly Glu Met Thr Val Glu Thr Val Thr545 550 555 560Ala Asp Lys Gly Glu Asp Pro Glu Leu Val Leu Arg Val Ala Gly Ala

565 570 575Leu Ala Met Glu Ser His His Ala Ile Ser Lys Ala Leu Val Lys Ala

580 585 590Ser Arg Glu Ala Arg Asp Thr Gly Ala Gly Gly Glu Asp Val Pro His

595 600 605Trp Ile Glu Val Gly Asn Val Glu Ile Thr Glu Ala Gly Ser Phe Gln

610 615 620Ala Thr Ile Glu Leu Pro Leu Ile Lys Pro Ser Gly Glu Lys Ile Met625 630 635 640Arg Thr Thr Glu Ala Leu Leu Trp Arg Pro Arg Ser Met Thr Glu Val

645 650 655Arg Glu His Leu Ser Pro Arg Leu Val Ala Ala Ala Thr Ser Gly Gly

660 665 670Ala Pro Leu Ile Val Arg Trp Lys Gly Lys Asp Arg Gly Val Ile Thr

675 680 685Leu Ser Asp His Val Arg Ser Asp Ser Ser Asp Ala Ile Ile Ala Ile

690 695 700Glu Glu Gln Gly Ile Glu Thr Met Met Leu Ser Arg Asp Thr Tyr Pro705 710 715 720Val Ala Arg Arg Tyr Ala Asp Ser Leu Gly Ile Thr His Val Leu Ala

725 730 735Gly Ile Ala Pro Gly Lys Lys Ala Gln Val Val Arg Ala Val His Thr

740 745 750Arg Gly Ser Thr Val Ala Met Ile Gly Asp Glu Ser Val Met Asp Cys

755 760 765Leu Lys Val Ala Asp Val Gly Val Leu Met Gly Val Asp Arg Pro Ser

770 775 780Asp Leu Arg Asp Asp Ser Asp Asp Pro Ala Ala Asp Val Val Val Met785 790 795 800Arg Glu Glu Val Met Ser Val Pro Thr Leu Phe Lys Leu Ala Arg Arg

805 810 815Tyr Ala Lys Leu Val Asn Gly Asn Ile Ala Leu Ala Trp Ile Tyr Asn

820 825 830Gly Val Ala Met Val Leu Ala Val Ser Gly Leu Leu His Pro Met Ala

835 840 845Ala Thr Val Ala Met Leu Ala Ser Ser Leu Leu Ile Glu Trp Arg Ser

850855860 Gly Arg Ala Arg Lys Tyr 865870<210>579<211>1925<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) }, (1902)<223>RXN01338<400>579aaa act tat acc cca aat ccc tgg atg tta ttc atc cgc tca ttt gat 48Lys Thr Tyr Thr Pro Asn Pro Trp Met Leu Phe Ile Arg Ser Phe Asp 151015 ggc atc atc act gtc gca gcc ctt gtt gcc atc gca ata cat ctc att 96Gly Ile Ile Thr Val AlaAla Leu Val Ala Ile Ala Ile His Leu Ile

20 25 30tta tgg ctg gct cta gat cta gat ggc ctt gct aaa aac tgg cct tta 144Leu Trp Leu Ala Leu Asp Leu Asp Gly Leu Ala Lys Asn Trp Pro Leu

35 40 45ata gcc atc gtt atc gta ggt ggc att ccg ttg atg tgg gat gtg ctg 192Ile Ala Ile Val Ile Val Gly Gly Ile Pro Leu Met Trp Asp Val Leu

50 55 60aaa tca gcc att aaa act cgc ggt ggc gcg gat act tta gca gca gtc 240Lys Ser Ala Ile Lys Thr Arg Gly Gly Ala Asp Thr Leu Ala Ala Val 65 70 75 80tcc atc att act tct gtg ttg tta ggg gag tgg ttg gtt gcc gcg atc 288Ser Ile Ile Thr Ser Val Leu Leu Gly Glu Trp Leu Val Ala Ala Ile

85 90 95atc gtg ctc atg ctc tct ggt ggt gaa gcg cta gaa gag gca gca tca 336Ile Val Leu Met Leu Ser Gly Gly Glu Ala Leu Glu Glu Ala Ala Ser

100 105 110cgg cga gcc agt ggc acc ttg gac gca ctt gcc cgg cgc gca cca agt 384Arg Arg Ala Ser Gly Thr Leu Asp Ala Leu Ala Arg Arg Ala Pro Ser

115 120 125aca gct cac cgc ctg ttg ggt gca acc att ctt gat gga acc gaa gag 432Thr Ala His Arg Leu Leu Gly Ala Thr Ile Leu Asp Gly Thr Glu Glu

130 135 140atc gcc gtg gaa gag atc acg gtt ggt gat tta gtg gcg gtg ctc ccg 480Ile Ala Val Glu Glu Ile Thr Val Gly Asp Leu Val Ala Val Leu Pro145 150 155 160cat gaa ctt tgt ccc gtg gat ggt gaa atc gtg gca ggc cac ggc acc 528His Glu Leu Cys Pro Val Asp Gly Glu Ile Val Ala Gly His Gly Thr

165 170 175atg gat gag tct tat ctc acg ggt gag ccc tat gtg gtg agt aaa tct 576Met Asp Glu Ser Tyr Leu Thr Gly Glu Pro Tyr Val Val Ser Lys Ser

180 185 190aaa ggt tcg caa gca atg tcg ggt gca gtc aat ggt gat act ccg ctg 624Lys Gly Ser Gln Ala Met Ser Gly Ala Val Asn Gly Asp Thr Pro Leu

195 200 205acg att gtt gcc aca aag ctt gcc cat gat tcc aga tac gcc caa att 672Thr Ile Val Ala Thr Lys Leu Ala His Asp Ser Arg Tyr Ala Gln Ile

210 215 220gtt ggt gta ctc cat gaa gca gaa aac aac cgc cca gaa atg cgc agg 720Val Gly Val Leu His Glu Ala Glu Asn Asn Arg Pro Glu Met Arg Arg225 230 235 240atg gct gac cgt ctt ggc gcg tgg tat acg gtg att gca ctt gcc ctc 768Met Ala Asp Arg Leu Gly Ala Trp Tyr Thr Val Ile Ala Leu Ala Leu

245 250 255ggt ggt ctt ggc tgg att gtc tcc ggc gac cca gtg agg ttc ttg gct 816Gly Gly Leu Gly Trp Ile Val Ser Gly Asp Pro Val Arg Phe Leu Ala

260 265 270gtt gtc gtt gtc gcc acc cca tgt cca ttg ctc att gca gtg cca gtg 864Val Val Val Val Ala Thr Pro Cys Pro Leu Leu Ile Ala Val Pro Val

275 280 285gcg atc atc ggt gcg att tct ctt gcg gct cgt cgg ggc atc atc gtg 912Ala Ile Ile Gly Ala Ile Ser Leu Ala Ala Arg Arg Gly Ile Ile Val

290 295 300aag aac cct gga atg ctg gaa aac gct tca gga gta aag aca gtg atg 960Lys Asn Pro Gly Met Leu Glu Asn Ala Ser Gly Val Lys Thr Val Met305 310 315 320ttc gat aag act gga acg ctc acc tat ggc agg cca gtg att act gat 1008Phe Asp Lys Thr Gly Thr Leu Thr Tyr Gly Arg Pro Val Ile Thr Asp

325 330 335atc cac act gct ccc gga gtt gag gaa gat aca gtc cta gct ttg gct 1056Ile His Thr Ala Pro Gly Val Glu Glu Asp Thr Val Leu Ala Leu Ala

340 345 350gct tca gta gag cgc tac tcc aga cac ccg ttg gct gac gcg att cgt 1104Ala Ser Val Glu Arg Tyr Ser Arg His Pro Leu Ala Asp Ala Ile Arg

355 360 365gag ggc gca aaa gcc agg gaa ctt cat ctg cct gat gta gtg gaa gta 1152Glu Gly Ala Lys Ala Arg Glu Leu His Leu Pro Asp Val Val Glu Val

370 375 380tcg gaa cgt cca gga cag gga cta acc ggc acg gtg ggc gag cac ctg 1200Ser Glu Arg Pro Gly Gln Gly Leu Thr Gly Thr Val Gly Glu His Leu385 390 395 400gtt cga ata acc aat agg cgc agc aca cta gaa att gat cca gac agc 1248Val Arg Ile Thr Asn Arg Arg Ser Thr Leu Glu Ile Asp Pro Asp Ser

405 410 415aag aac tac att ccg gtg aca agt tcc ggc atg gaa tct gtg gtg ctt 1296Lys Asn Tyr Ile Pro Val Thr Ser Ser Gly Met Glu Ser Val Val Leu

420 425 430gtt gat gat aaa tat gca gca ctc att cgc ctc cgg gat gaa cct cgt 1344Val Asp Asp Lys Tyr Ala Ala Leu Ile Arg Leu Arg Asp Glu Pro Arg

435 440 445gca tct gcc agt gag ttc atc gcg cac ttg ccc aag aag cac aaa gtg 1392Ala Ser Ala Ser Glu Phe Ile Ala His Leu Pro Lys Lys His Lys Val

450 455 460gac aag ctc atg att atc tct ggt gat cgc gca tct gag gtt cgt tac 1440Asp Lys Leu Met Ile Ile Ser Gly Asp Arg Ala Ser Glu Val Arg Tyr465 470475 480ctt gcg gac aag gtt ggc att gat gag gta cac gca gag gcc tca ccg 1488Leu Ala Asp Lys Val Gly Ile Asp Glu Val His Ala Glu Ala Ser Pro

485 490 495gaa gac aag ctg aac att gtt aat cgg cat aat gag cac ggc gcc acc 1536Glu Asp Lys Leu Asn Ile Val Asn Arg His Asn Glu His Gly Ala Thr

500 505 510atg ttc tta ggt gat gga atc aac gat gcg cca gcc atg gcc gtt gcc 1584Met Phe Leu Gly Asp Gly Ile Asn Asp Ala Pro Ala Met Ala Val Ala

515 520 525acc gtt ggt gtc gcg atg gga gca gac tcc gat gtc acg tcc gaa gca 1632Thr Val Gly Val Ala Met Gly Ala Asp Ser Asp Val Thr Ser Glu Ala

530 535 540gca gat gct gtg att ttg gat tct tcc ctg gaa cgt ctc gac gat ctg 1680Ala Asp Ala Val Ile Leu Asp Ser Ser Leu Glu Arg Leu Asp Asp Leu545 550 555 560ctc cac atc agt gca cgg atg cgt cga ata gcg ttg caa tct gcg ggc 1728Leu His Ile Ser Ala Arg Met Arg Arg Ile Ala Leu Gln Ser Ala Gly

565 570 575ggt ggc atg gcg ttg agt gtc ata gga atg atc ctc gcg gta ttt gga 1776Gly Gly Met Ala Leu Ser Val Ile Gly Met Ile Leu Ala Val Phe Gly

580 585 590ttc ttg acg cca ctg atg ggt gcg atc ttc caa gag gtc att gac gtg 1824Phe Leu Thr Pro Leu Met Gly Ala Ile Phe Gln Glu Val Ile Asp Val

595 600 605ctg gct atc ctc aat tcc gct cgg gtc gca ctg cca cgc gga gcg att 1872Leu Ala Ile Leu Asn Ser Ala Arg Val Ala Leu Pro Arg Gly Ala Ile

610615620 agt gat ttt gat acg caa gaa aaa gtt tct tagcagggta acctaaatgt 1922Ser AspPhe Asp Thr Gln Glu Lys Val Ser 625630 cgt1925<210>580<211>634<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>580Lys Thr Tyr Thr Pro Asn Pro Trp Met Leu Phe Ile Arg Ser Phe Asp 151015 Gly Ile Ile Thr Val Ala Ala Leu Val Ala Ile Ala Ile His Leu Ile

20 25 30Leu Trp Leu Ala Leu Asp Leu Asp Gly Leu Ala Lys Asn Trp Pro Leu

35 40 45Ile Ala Ile Val Ile Val Gly Gly Ile Pro Leu Met Trp Asp Val Leu

50 55 60Lys Ser Ala Ile Lys Thr Arg Gly Gly Ala Asp Thr Leu Ala Ala Val 65 70 75 80Ser Ile Ile Thr Ser Val Leu Leu Gly Glu Trp Leu Val Ala Ala Ile

85 90 95Ile Val Leu Met Leu Ser Gly Gly Glu Ala Leu Glu Glu Ala Ala Ser

100 105 110Arg Arg Ala Ser Gly Thr Leu Asp Ala Leu Ala Arg Arg Ala Pro Ser

115 120 125Thr Ala His Arg Leu Leu Gly Ala Thr Ile Leu Asp Gly Thr Glu Glu

130 135 140Ile Ala Val Glu Glu Ile Thr Val Gly Asp Leu Val Ala Val Leu Pro145 150 155 160His Glu Leu Cys Pro Val Asp Gly Glu Ile Val Ala Gly His Gly Thr

165 170 175Met Asp Glu Ser Tyr Leu Thr Gly Glu Pro Tyr Val Val Ser Lys Ser

180 185 190Lys Gly Ser Gln Ala Met Ser Gly Ala Val Asn Gly Asp Thr Pro Leu

195 200 205Thr Ile Val Ala Thr Lys Leu Ala His Asp Ser Arg TyrAla Gln Ile

210 215 220Val Gly Val Leu His Glu Ala Glu Asn Asn Arg Pro Glu Met Arg Arg225 230 235 240Met Ala Asp Arg Leu Gly Ala Trp Tyr Thr Val Ile Ala Leu Ala Leu

245 250 255Gly Gly Leu Gly Trp Ile Val Ser Gly Asp Pro Val Arg Phe Leu Ala

260 265 270Val Val Val Val Ala Thr Pro Cys Pro Leu Leu Ile Ala Val Pro Val

275 280 285Ala Ile Ile Gly Ala Ile Ser Leu Ala Ala Arg Arg Gly Ile Ile Val

290 295 300Lys Asn Pro Gly Met Leu Glu Asn Ala Ser Gly Val Lys Thr Val Met305 310 315 320Phe Asp Lys Thr Gly Thr Leu Thr Tyr Gly Arg Pro Val Ile Thr Asp

325 330 335Ile His Thr Ala Pro Gly Val Glu Glu Asp Thr Val Leu Ala Leu Ala

340 345 350Ala Ser Val Glu Arg Tyr Ser Arg His Pro Leu Ala Asp Ala Ile Arg

355 360 365Glu Gly Ala Lys Ala Arg Glu Leu His Leu Pro Asp Val Val Glu Val

370 375 380Ser Glu Arg Pro Gly Gln Gly Leu Thr Gly Thr Val Gly Glu His Leu385 390 395 400Val Arg Ile Thr Asn Arg Arg Ser Thr Leu Glu Ile Asp Pro Asp Ser

405 410 415Lys Asn Tyr Ile Pro Val Thr Ser Ser Gly Met Glu Ser Val Val Leu

420 425 430Val Asp Asp Lys Tyr Ala Ala Leu Ile Arg LeuArg Asp Glu Pro Arg

435 440 445Ala Ser Ala Ser Glu Phe Ile Ala His Leu Pro Lys Lys His Lys Val

450 455 460Asp Lys Leu Met Ile Ile Ser Gly Asp Arg Ala Ser Glu Val Arg Tyr465 470 475 480Leu Ala Asp Lys Val Gly Ile Asp Glu Val His Ala Glu Ala Ser Pro

485 490 495Glu Asp Lys Leu Asn Ile Val Asn Arg His Asn Glu His Gly Ala Thr

500 505 510Met Phe Leu Gly Asp Gly Ile Asn Asp Ala Pro Ala Met Ala Val Ala

515 520 525Thr Val Gly Val Ala Met Gly Ala Asp Ser Asp Val Thr Ser Glu Ala

530 535 540Ala Asp Ala Val Ile Leu Asp Ser Ser Leu Glu Arg Leu Asp Asp Leu545 550 555 560Leu His Ile Ser Ala Arg Met Arg Arg Ile Ala Leu Gln Ser Ala Gly

565 570 575Gly Gly Met Ala Leu Ser Val Ile Gly Met Ile Leu Ala Val Phe Gly

580 585 590Phe Leu Thr Pro Leu Met Gly Ala Ile Phe Gln Glu Val Ile Asp Val

595 600 605Leu Ala Ile Leu Asn Ser Ala Arg Val Ala Leu Pro Arg Gly Ala Ile

610615620 Ser Asp Phe Asp Thr Gln Glu Lys Val Ser 625630<210>581<211>1917<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1894)<223>RXN00980<400>581agagagaaag ggagaaatca tgaaaacgtg gaagacctgg ggggtcgtcg gagcttcagg 60cctcttgatt attttgtcgt ggttgagttc atcgagcccg atg ctg gca gat gca 115

Met Leu Ala Asp Ala

1 5ttc atg atc gcg gct gca att gtt gca ggt tgg ccg atc gcg cag tct 163Phe Met Ile Ala Ala Ala Ile Val Ala Gly Trp Pro Ile Ala Gln Ser

10 15 20gca tat caa gca ctt cgc att cga atg gtg tcg att gac tta ctg gtc 211Ala Tyr Gln Ala Leu Arg Ile Arg Met Val Ser Ile Asp Leu Leu Val

25 30 35gtt gtg gct gcc gtt ggt gcc atg ttc atc aac aac tat tgg gag tct 259Val Val Ala Ala Val Gly Ala Met Phe Ile Asn Asn Tyr Trp Glu Ser

40 45 50gcg gcg gtg acg ttc ctc ttt gcc ctt ggc aag gca ctg gaa cgc gcg 307Ala Ala Val Thr Phe Leu Phe Ala Leu Gly Lys Ala Leu Glu Arg Ala

55 60 65aca atg aac cgc aca cga aaa gca cta tcg gat ctg gtg gat gca gct 355Thr Met Asn Arg Thr Arg Lys Ala Leu Ser Asp Leu Val Asp Ala Ala 70 75 80 85cca gaa act gca aca agg ctc aac gcg gat gac tca aca gag gta gtt 403Pro Glu Thr Ala Thr Arg Leu Asn Ala Asp Asp Ser Thr Glu Val Val

90 95 100gag ctg tgg gag ctt gag ccc ggt gac atc gtc ttg gta cgc aat ggc 451Glu Leu Trp Glu Leu Glu Pro Gly Asp Ile Val Leu Val Arg Asn Gly

105 110 115gaa caa att ccc gtc gat gga aac gtg att gcg ggt gtc ggt gga att 499Glu Gln Ile Pro Val Asp Gly Asn Val Ile Ala Gly Val Gly Gly Ile

120 125 130gat gaa tcc aac atc acg ggt gaa tca atg ccg gct gaa aag ggt caa 547Asp Glu Ser Asn Ile Thr Gly Glu Ser Met Pro Ala Glu Lys Gly Gln

135 140 145ggc tct gat gtg tat gca gga acc tgg ctg cga tct ggt gtt ttg aga 595Gly Ser Asp Val Tyr Ala Gly Thr Trp Leu Arg Ser Gly Val Leu Arg150 155 160 165gtc gag gca aca gga att ggt tca gac tca act ttg gca aaa atc att 643Val Glu Ala Thr Gly Ile Gly Ser Asp Ser Thr Leu Ala Lys Ile Ile

170 175 180cac cgc gtt gaa gac gcc cag gat gac aaa gcc cgc aca caa aca ttc 691His Arg Val Glu Asp Ala Gln Asp Asp Lys Ala Arg Thr Gln Thr Phe

185 190 195tta gag aaa ttc tct aag tgg tac acc ccg ggc gtc atg atc gcc gcc 739Leu Glu Lys Phe Ser Lys Trp Tyr Thr Pro Gly Val Met Ile Ala Ala

200 205 210gca gtg gtg gga ctt atc acc tgg gac gta gaa cta gca ctg acg ctc 787Ala Val Val Gly Leu Ile Thr Trp Asp Val Glu Leu Ala Leu Thr Leu

215 220 225tta gtg atc ggc tgc ccc ggc gcg ttg gtt atc tcc atc ccg gtg tcc 835Leu Val Ile Gly Cys Pro Gly Ala Leu Val Ile Ser Ile Pro Val Ser230 235 240 245atc gtc gca ggc atc ggc cgt gct gca cgc gat ggc gtg ctg atc aag 883Ile Val Ala Gly Ile Gly Arg Ala Ala Arg Asp Gly Val Leu Ile Lys

250 255 260ggt gga gaa tac cta gaa acc gcc gcg aaa gtc gac gtc gtt gtc gtg 931Gly Gly Glu Tyr Leu Glu Thr Ala Ala Lys Val Asp Val Val Val Val

265 270 275gac aaa act gga acg ctg acc acc ggc cgc cca gaa ctc aca gac gta 979Asp Lys Thr Gly Thr Leu Thr Thr Gly Arg Pro Glu Leu Thr Asp Val

280285 290gaa gtc atc gag ccc gcc tac agc cag ggc gag gtg ctg gag ctc gcc 1027Glu Val Ile Glu Pro Ala Tyr Ser Gln Gly Glu Val Leu Glu Leu Ala

295 300 305gcg cgc gcc gag acg gct tca gaa cat ccg ctt gcc gac gcc atc atc 1075Ala Arg Ala Glu Thr Ala Ser Glu His Pro Leu Ala Asp Ala Ile Ile310 315 320 325cgt ggt gcc cag gat cgg ggg ctg tcc aca aca ttg gtg gaa gca gct 1123Arg Gly Ala Gln Asp Arg Gly Leu Ser Thr Thr Leu Val Glu Ala Ala

330 335 340gaa aac atc acc ggc cga ggc att atc gca aat gtt gat gga cag gca 1171Glu Asn Ile Thr Gly Arg Gly Ile Ile Ala Asn Val Asp Gly Gln Ala

345 350 355gtt gct gtt gga tct gct gag tta ctt gat cat gaa cca gac tcg acc 1219Val Ala Val Gly Ser Ala Glu Leu Leu Asp His Glu Pro Asp Ser Thr

360 365 370agg atc ctg gag cta aat gcc gaa gga aag acc gcg atg ttt gtc gga 1267Arg Ile Leu Glu Leu Asn Ala Glu Gly Lys Thr Ala Met Phe Val Gly

375 380 385gtg aac gga cac gcc att gga atc gtg gcc gtc gcc gac gcc gtt cgt 1315Val Asn Gly His Ala Ile Gly Ile Val Ala Val Ala Asp Ala Val Arg390 395 400 405tca gat tct gcc tca gca atc gaa tcg ctg cat aag gcg ggc att caa 1363Ser Asp Ser Ala Ser Ala Ile Glu Ser Leu His Lys Ala Gly Ile Gln

410 415 420gtt gtc atg gcg act ggc gac gct cac cgc gtt gca caa aac gtg gcc 1411Val Val Met Ala Thr Gly Asp Ala His Arg Val Ala Gln Asn Val Ala

425 430 435tcc aag ctg gga gtg gat gaa gtc tac tca gag cta ctc cct gaa cag 1459Ser Lys Leu Gly Val Asp Glu Val Tyr Ser Glu Leu Leu Pro Glu Gln

440 445 450aaa tta gaa ctg gtg cgt gat ctg caa gct gcc ggc aaa acg gtc gcg 1507Lys Leu Glu Leu Val Arg Asp Leu Gln Ala Ala Gly Lys Thr Val Ala

455 460 465atg gtg ggt gac gga gtc aac gac acc cca gca ttg gca gct gct gat 1555Met Val Gly Asp Gly Val Asn Asp Thr Pro Ala Leu Ala Ala Ala Asp470 475 480 485atc gga gta gcg atg ggc gtg gca ggt tcc cct gca gcc att gaa acc 1603Ile Gly Val Ala Met Gly Val Ala Gly Ser Pro Ala Ala Ile Glu Thr

490 495 500gct gat atc gca ctc atg gcg gat cgt ctc cca cgg ctg gca cat gca 1651Ala Asp Ile Ala Leu Met Ala Asp Arg Leu Pro Arg Leu Ala His Ala

505 510 515gtg acc ttg gca aaa cgc acc gta aga acc atg cgc atc aat att ctg 1699Val Thr Leu Ala Lys Arg Thr Val Arg Thr Met Arg Ile Asn Ile Leu

520 525 530att gcg ttg gct acc gtg atg gtg tta cta gct ggc gtc cta ttt ggc 1747Ile Ala Leu Ala Thr Val Met Val Leu Leu Ala Gly Val Leu Phe Gly

535 540 545gga gtt acc atg tcg gtt ggc atg ctc gtt cac gaa gca agc gtg ctg 1795Gly Val Thr Met Ser Val Gly Met Leu Val His Glu Ala Ser Val Leu550 555 560 565ctt gtt atc agc atc gcc atg ctg ttg ctg cgt cca aca ctt aaa gaa 1843Leu Val Ile Ser Ile Ala Met Leu Leu Leu Arg Pro Thr Leu Lys Glu

570 575 580gat gct gcg caa gca agt gat att aaa cgc tcg gaa ata caa cag atc 1891Asp Ala Ala Gln Ala Ser Asp Ile Lys Arg Ser Glu Ile Gln Gln Ile

585590595 gca taaccaatgg ctgggtactg atg 1917Ala<210>582<211>598<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>582Met Leu Ala Asp Ala Phe Met Ile Ala Ala Ala Ile Val Ala Gly Trp 151015 Pro Ile Ala Gln Ser Ala Tyr Gln Ala Leu Arg Ile Arg Met Val Ser

20 25 30Ile Asp Leu Leu Val Val Val Ala Ala Val Gly Ala Met Phe Ile Asn

35 40 45Asn Tyr Trp Glu Ser Ala Ala Val Thr Phe Leu Phe Ala Leu Gly Lys

50 55 60Ala Leu Glu Arg Ala Thr Met Asn Arg Thr Arg Lys Ala Leu Ser Asp 65 70 75 80Leu Val Asp Ala Ala Pro Glu Thr Ala Thr Arg Leu Asn Ala Asp Asp

85 90 95Ser Thr Glu Val Val Glu Leu Trp Glu Leu Glu Pro Gly Asp Ile Val

100 105 110Leu Val Arg Asn Gly Glu Gln Ile Pro Val Asp Gly Asn Val Ile Ala

115 120 125Gly Val Gly Gly Ile Asp Glu Ser Asn Ile Thr Gly Glu Ser Met Pro

130 135 140Ala Glu Lys Gly Gln Gly Ser Asp Val Tyr Ala Gly Thr Trp Leu Arg145 150 155 160Ser Gly Val Leu Arg Val Glu Ala Thr Gly Ile Gly Ser Asp Ser Thr

165 170 175Leu Ala Lys Ile Ile His Arg Val Glu Asp Ala Gln Asp Asp Lys Ala

180 185 190Arg Thr Gln Thr Phe Leu Glu Lys Phe Ser Lys Trp Tyr Thr Pro Gly

195 200 205Val Met Ile Ala Ala Ala Val Val Gly Leu Ile Thr Trp Asp Val Glu

210 215 220Leu Ala Leu Thr Leu Leu Val Ile Gly Cys Pro Gly Ala Leu Val Ile225 230 235 240Ser Ile Pro Val Ser Ile Val Ala Gly Ile Gly Arg Ala Ala Arg Asp

245 250 255Gly Val Leu Ile Lys Gly Gly Glu Tyr Leu Glu Thr Ala Ala Lys Val

260 265 270Asp Val Val Val Val Asp Lys Thr Gly Thr Leu Thr Thr Gly Arg Pro

275 280 285Glu Leu Thr Asp Val Glu Val Ile Glu Pro Ala Tyr Ser Gln Gly Glu

290 295 300Val Leu Glu Leu Ala Ala Arg Ala Glu Thr Ala Ser Glu His Pro Leu305 310 315 320Ala Asp Ala Ile Ile Arg Gly Ala Gln Asp Arg Gly Leu Ser Thr Thr

325 330 335Leu Val Glu Ala Ala Glu Asn Ile Thr Gly Arg Gly Ile Ile Ala Asn

340 345 350Val Asp Gly Gln Ala Val Ala Val Gly Ser Ala Glu Leu Leu Asp His

355 360 365Glu Pro Asp Ser Thr Arg Ile Leu Glu Leu Asn Ala Glu Gly Lys Thr

370 375 380Ala Met Phe Val Gly Val Asn Gly His Ala Ile Gly Ile Val Ala Val385 390 395 400Ala Asp Ala Val Arg Ser Asp Ser Ala Ser Ala Ile Glu Ser Leu His

405 410 415Lys Ala Gly Ile Gln Val Val Met Ala Thr Gly Asp Ala His Arg Val

420 425 430Ala Gln Asn Val Ala Ser Lys Leu Gly Val Asp Glu Val Tyr Ser Glu

435 440 445Leu Leu Pro Glu Gln Lys Leu Glu Leu Val Arg Asp Leu Gln Ala Ala

450 455 460Gly Lys Thr Val Ala Met Val Gly Asp Gly Val Asn Asp Thr Pro Ala465 470 475 480Leu Ala Ala Ala Asp Ile Gly Val Ala Met Gly Val Ala Gly Ser Pro

485 490 495Ala Ala Ile Glu Thr Ala Asp Ile Ala Leu Met Ala Asp Arg Leu Pro

500 505 510Arg Leu Ala His Ala Val Thr Leu Ala Lys Arg Thr Val Arg Thr Met

515 520 525Arg Ile Asn Ile Leu Ile Ala Leu Ala Thr Val Met Val Leu Leu Ala

530 535 540Gly Val Leu Phe Gly Gly Val Thr Met Ser Val Gly Met Leu Val His545 550 555 560Glu Ala Ser Val Leu Leu Val Ile Ser Ile Ala Met Leu Leu Leu Arg

565 570 575Pro Thr Leu Lys Glu Asp Ala Ala Gln Ala Ser Asp Ile Lys Arg Ser

580 585 590Glu Ile Gln Gln Ile Ala

595<210>583<211>1296<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1273)<223>RXN00099<400>583ctctggtgaa gaggatgttg actcgggaga ttcttccact gattcactga ttaagtggta 60ccgcgcaaat aggtagtcgc ttgcttatag ggtcaggggc gtg aag aat cct cgc 115

Val Lys Asn Pro Arg

1 5ctc ata gca ctg gcc gct atc atc ctg acc tcg ttc aat ctg cga aca 163Leu Ile Ala Leu Ala Ala Ile Ile Leu Thr Ser Phe Asn Leu Arg Thr

10 15 20gct att act gct tta gct ccg ctg gtt tct gag att cgg gat gat tta 211Ala Ile Thr Ala Leu Ala Pro Leu Val Ser Glu Ile Arg Asp Asp Leu

25 30 35ggg gtt agt gct tct ctt att ggt gtg ttg ggc atg atc ccg act gct 259Gly Val Ser Ala Ser Leu Ile Gly Val Leu Gly Met Ile Pro Thr Ala

40 45 50atg ttc gcg gat gct gcg ttt gcg ctt ccg tcg ttg aag agg aag ttc 307Met Phe Ala Asp Ala Ala Phe Ala Leu Pro Ser Leu Lys Arg Lys Phe

55 60 65act act tcc caa ctg ttg atg ttt gcc atg ctg ttg act gct gcc ggt 355Thr Thr Ser Gln Leu Leu Met Phe Ala Met Leu Leu Thr Ala Ala Gly 70 75 80 85cag att att cgt gtc gct gga cct gct tcg ctg ttg atg gtc ggt act 403Gln Ile Ile Arg Val Ala Gly Pro Ala Ser Leu Leu Met Val Gly Thr

90 95 100gtg ttc gcg atg ttt gcg atc gga gtt acc aat gtg ttg ctt ccg att 451Val Phe Ala Met Phe Ala Ile Gly Val Thr Asn Val Leu Leu Pro Ile

105 110 115gct gtt agg gag tat ttt ccg cgt cac gtc ggt gga atg tcg aca act 499Ala Val Arg Glu Tyr Phe Pro Arg His Val Gly Gly Met Ser Thr Thr

120 125 130tat ctg gtg tcg ttc cag att gtt cag gca ctt gct ccg acg ctt gcc 547Tyr Leu Val Ser Phe Gln Ile Val Gln Ala Leu Ala Pro Thr Leu Ala

135 140 145gtg ccg att tct cag tgg gct aca cat gtg ggg ttg acc ggttgg agg 595Val Pro Ile Ser Gln Trp Ala Thr His Val Gly Leu Thr Gly Trp Arg150 155 160 165gtg tcg ctc ggt tcg tgg gcg ctg ctg ggg ttg gtt gcg gcg att tcg 643Val Ser Leu Gly Ser Trp Ala Leu Leu Gly Leu Val Ala Ala Ile Ser

170 175 180tgg att ccg ctg ttg agt ttg cag ggt gcc agg gtt gtt gcg gcg ccg 691Trp Ile Pro Leu Leu Ser Leu Gln Gly Ala Arg Val Val Ala Ala Pro

185 190 195tcg aag gtt tct ctt cct gtg tgg aag tct tcg gtt ggt gtg ggg ctc 739Ser Lys Val Ser Leu Pro Val Trp Lys Ser Ser Val Gly Val Gly Leu

200 205 210ggg ttg atg ttt ggg ttt act tcg ttt gcg acg tat atc ctc atg ggt 787Gly Leu Met Phe Gly Phe Thr Ser Phe Ala Thr Tyr Ile Leu Met Gly

215 220 225ttt atg ccg cag atg gta ggt gat cct cag ctc ggt gcg gtg ttg tta 835Phe Met Pro Gln Met Val Gly Asp Pro Gln Leu Gly Ala Val Leu Leu230 235 240 245ggc tgg tgg tca att ttg gga ttg ccg ctg aac att ctg gga ccg tgg 883Gly Trp Trp Ser Ile Leu Gly Leu Pro Leu Asn Ile Leu Gly Pro Trp

250 255 260ttg gtg acg cgt ttc act aac tgc ttc ccg atg gtt gtt atc gcc agt 931Leu Val Thr Arg Phe Thr Asn Cys Phe Pro Met Val Val Ile Ala Ser

265 270 275gtc atg ttt ctc atc ggt aat ggt ggg ttt tgt ttg gct ccg gat gtt 979Val Met Phe Leu Ile Gly Asn Gly Gly Phe Cys Leu Ala Pro Asp Val

280 285 290gcg ccg tgg ttg tgg gcg acg ttg tct ggt ctt ggt ccc ctt gcg ttc 1027Ala Pro Trp Leu Trp Ala Thr Leu Ser Gly Leu Gly Pro Leu Ala Phe

295300 305ccg atg gcg ttg acg ctc att aat att cgt gct gaa act agt gct ggt 1075Pro Met Ala Leu Thr Leu Ile Asn Ile Arg Ala Glu Thr Ser Ala Gly310 315 320 325gct tct gcg ttg agt tcc ttc ggg cag ggt ttg ggt tat acg att gcg 1123Ala Ser Ala Leu Ser Ser Phe Gly Gln Gly Leu Gly Tyr Thr Ile Ala

330 335 340tgt ttc ggt ccc ttg ttg act ggt ttc att gtc gat gcg aca ggc agc 1171Cys Phe Gly Pro Leu Leu Thr Gly Phe Ile Val Asp Ala Thr Gly Ser

345 350 355ttc cga aca atc ttt gtg ctt ttt gcg gtt gca aca ctc ttc gtt att 1219Phe Arg Thr Ile Phe Val Leu Phe Ala Val Ala Thr Leu Phe Val Ile

360 365 370aga ggc ggt tac ttt gcg aca agg cag gtt tac gtc gaa aag ctt tta 1267Arg Gly Gly Tyr Phe Ala Thr Arg Gln Val Tyr Val Glu Lys Leu Leu

375380385 aat cgc taggatggcg ctatgccgca aag 1296Asn Arg390<210>584<211>391<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>584Val Lys Asn Pro Arg Leu Ile Ala Leu Ala Ala Ile Ile Leu Thr Ser 151015 Phe Asn Leu Arg Thr Ala Ile Thr Ala Leu Ala Pro Leu Val Ser Glu

20 25 30Ile Arg Asp Asp Leu Gly Val Ser Ala Ser Leu Ile Gly Val Leu Gly

35 40 45Met Ile Pro Thr Ala Met Phe Ala Asp Ala Ala Phe Ala Leu Pro Ser

50 55 60Leu Lys Arg Lys Phe Thr Thr Ser Gln Leu Leu Met Phe Ala Met Leu 65 70 75 80Leu Thr Ala Ala Gly Gln Ile Ile Arg Val Ala Gly Pro Ala Ser Leu

8590 95Leu Met Val Gly Thr Val Phe Ala Met Phe Ala Ile Gly Val Thr Asn

100 105 110Val Leu Leu Pro Ile Ala Val Arg Glu Tyr Phe Pro Arg His Val Gly

115 120 125 Gly Met Ser Thr Thr Tyr Leu Val Ser Phe Gln Ile Val Gln Ala Leu

130 135 140Ala Pro Thr Leu Ala Val Pro Ile Ser Gln Trp Ala Thr His Val Gly145 150 155 160Leu Thr Gly Trp Arg Val Ser Leu Gly Ser Trp Ala Leu Leu Gly Leu

165 170 175Val Ala Ala Ile Ser Trp Ile Pro Leu Leu Ser Leu Gln Gly Ala Arg

180 185 190Val Val Ala Ala Pro Ser Lys Val Ser Leu Pro Val Trp Lys Ser Ser

195 200 205Val Gly Val Gly Leu Gly Leu Met Phe Gly Phe Thr Ser Phe Ala Thr

210 215 220Tyr Ile Leu Met Gly Phe Met Pro Gln Met Val Gly Asp Pro Gln Leu225 230 235 240Gly Ala Val Leu Leu Gly Trp Trp Ser Ile Leu Gly Leu Pro Leu Asn

245 250 255Ile Leu Gly Pro Trp Leu Val Thr Arg Phe Thr Asn Cys Phe Pro Met

260 265 270Val Val Ile Ala Ser Val Met Phe Leu Ile Gly Asn Gly Gly Phe Cys

275 280 285Leu Ala Pro Asp Val Ala Pro Trp Leu Trp Ala Thr Leu Ser Gly Leu

290 295 300Gly Pro Leu Ala Phe Pro Met Ala Leu Thr Leu Ile Asn Ile Arg Ala305 310315 320Glu Thr Ser Ala Gly Ala Ser Ala Leu Ser Ser Phe Gly Gln Gly Leu

325 330 335Gly Tyr Thr Ile Ala Cys Phe Gly Pro Leu Leu Thr Gly Phe Ile Val

340 345 350Asp Ala Thr Gly Ser Phe Arg Thr Ile Phe Val Leu Phe Ala Val Ala

355 360 365Thr Leu Phe Val Ile Arg Gly Gly Tyr Phe Ala Thr Arg Gln Val Tyr

370375380 Val Glu Lys Leu Leu Asn Arg 385390<210>585<211>387<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (364)<223>RXN02662<400>585ccaaggtgtc accctcaccg ttgccatcgc cttcatcatc gtcaatatcg ccgtggacct 60gctctacgtc ctggtcaatc cacgtattag gagcatctag atg cgc cgt aaa cta 115

Met Arg Arg Lys Leu

1 5acc acc aca tta gaa aac aag ccc ggt gca cga ctt ggt ggc ttc cgc 163Thr Thr Thr Leu Glu Asn Lys Pro Gly Ala Arg Leu Gly Gly Phe Arg

10 15 20gca ctt gca cca act tca aaa atc gcg ctg gtt ttc ctt ctc ctg atc 211Ala Leu Ala Pro Thr Ser Lys Ile Ala Leu Val Phe Leu Leu Leu Ile

25 30 35ttc ctc ctc gcg atc ttt gcc cca ctg att gct aaa tac gat cca ctg 259Phe Leu Leu Ala Ile Phe Ala Pro Leu Ile Ala Lys Tyr Asp Pro Leu

40 45 50gcc tcc gga act cca gtc cag cct cca agc ggt gag cac tgg ttt ggt 307Ala Ser Gly Thr Pro Val Gln Pro Pro Ser Gly Glu His Trp Phe Gly

556065 acc gac gccatc ggc cgc gat att ttc tcc cgc gta gcc acg gcg cca 355Thr Asp Ala Ile Gly Arg Asp Ile Phe Ser Arg Val Ala Thr Ala Pro 70758085 gag cct ccc tgatcattgg tcttttcgct acg 387Glu Pro<210>586<211>88<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>586Met Arg Arg Lys Leu Thr Thr Thr Leu Glu Asn Lys Pro Gly Ala Arg 151015 Leu Gly Gly Phe Arg Ala Leu Ala Pro Thr Ser Lys Ile Ala Leu Val

20 25 30Phe Leu Leu Leu Ile Phe Leu Leu Ala Ile Phe Ala Pro Leu Ile Ala

35 40 45Lys Tyr Asp Pro Leu Ala Ser Gly Thr Pro Val Gln Pro Pro Ser Gly

50 55 60Glu His Trp Phe Gly Thr Asp Ala Ile Gly Arg Asp Ile Phe Ser Arg 65 70 75 80Val Ala Thr Ala Pro Glu Pro Pro

85<210>587<211>972<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (949)<223>RXN02442<400>587gccgtgatgt tgttgagcgc gatgtgattg ccgtatgtgc atgtgagatt ccggacgctg 60agttctgcca ttccttaatg ataacggtta tcattttcaa atg aag ttt ttt act 115

Met Lys Phe Phe Thr

1 5gac gcc ctc ata gtg cct ttt gac gtt tca ttc atc tcc cgc gcc ctg 163Asp Ala Leu Ile Val Pro Phe Asp Val Ser Phe Ile Ser Arg Ala Leu

10 15 20gtc gcc gga tgc ctg gcc gca att tta tgc tca ctc att gga acg tgg 211Val Ala Gly Cys Leu Ala Ala Ile Leu Cys Ser Leu Ile Gly Thr Trp

25 30 35gtt att ttg cgc agg cta acc ttt ttc ggc gac gct atg tcg cac ggc 259Val Ile Leu Arg Arg Leu Thr Phe Phe Gly Asp Ala Met Ser His Gly

40 45 50ttg ctc ccc gga gta gcc acg gca tca cta ttg ggc gga aat ctc atg 307Leu Leu Pro Gly Val Ala Thr Ala Ser Leu Leu Gly Gly Asn Leu Met

55 60 65ttc ggc gca gca atc agc gca tta atc atg tca gcc gga gtg gtg tgg 355Phe Gly Ala Ala Ile Ser Ala Leu Ile Met Ser Ala Gly Val Val Trp 70 75 80 85acc agc aga aaa tcc agc ctc tcc caa gac gtc agc att ggc ctg caa 403Thr Ser Arg Lys Ser Ser Leu Ser Gln Asp Val Ser Ile Gly Leu Gln

90 95 100ttt att acc atg ctt tcc ctc ggc gtg gtt att gtg tcc cac tcc gat 451Phe Ile Thr Met Leu Ser Leu Gly Val Val Ile Val Ser His Ser Asp

105 110 115tcc cac gcc gta gac ctc acc agt ttc ctt ttt gga gac att ctt ggc 499Ser His Ala Val Asp Leu Thr Ser Phe Leu Phe Gly Asp Ile Leu Gly

120 125 130gtg cga ccc tcg gat ata ttc atc atc gcc att gca aca gtg ttg ggt 547Val Arg Pro Set Asp Ile Phe Ile Ile Ala Ile Ala Thr Val Leu Gly

135 140 145gga ttg act att ttt ctc ttc cac cga cag ttc act gca ctc gct ttc 595Gly Leu Thr Ile Phe Leu Phe His Arg Gln Phe Thr Ala Leu Ala Phe150 155 160 165gac gag cgt aaa gct cac acc tta gga ctc aat ccc cgc ttt gca cac 643Asp Glu Arg Lys Ala His Thr Leu Gly Leu Asn Pro Arg Phe Ala His

170 175 180cta ctc atg ctg gca ctg atc gca tta gct acg gtg gtg tcg ttt cag 691Leu Leu Met Leu Ala Leu Ile Ala Leu Ala Thr Val Val Ser Phe Gln

185 190 195gtg gtg gga acg ctt tta gtg ttt gga ctt ctc att ggt ccg ccc gcc 739Val Val Gly Thr Leu Leu Val Phe Gly Leu Leu Ile Gly Pro Pro Ala

200 205 210acg gct gca ctt tta gtg caa gac aaa gca agt att tca ctg atc atg 787Thr Ala Ala Leu Leu Val Gln Asp Lys Ala Ser Ile Ser Leu Ile Met

215 220 225atc gtc gcg tcg ctt ctt gga tgc gcg gaa att tac ctc ggg ctt tta 835Ile Val Ala Ser Leu Leu Gly Cys Ala Glu Ile Tyr Leu Gly Leu Leu230 235 240 245atc agc tgg cac gca agc act gcc gcg gga gcc act atc act ttg tta 883Ile Ser Trp His Ala Ser Thr Ala Ala Gly Ala Thr Ile Thr Leu Leu

250 255 260agt gct gcg ata ttt ttt gcc acc tta ttg aca aag agt gcc att agt 931Ser Ala Ala Ile Phe Phe Ala Thr Leu Leu Thr Lys Ser Ala Ile Ser

265 270 275agg tta aac ttc acc gcg tgatactgaa agacattttc aat 972Arg Leu Asn Phe Thr Ala

280<210>588<211>283<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>588Met Lys Phe Phe Thr Asp Ala Leu Ile Val Pro Phe Asp Val Ser Phe 151015 Ile Ser Arg Ala Leu Val Ala Gly Cys Leu Ala Ala Ile Leu Cys Ser

20 25 30Leu Ile Gly Thr Trp Val Ile Leu Arg Arg Leu Thr Phe Phe Gly Asp

35 40 45Ala Met Ser His Gly Leu Leu Pro Gly Val Ala Thr Ala Ser Leu Leu

50 55 60Gly Gly Asn Leu Met Phe Gly Ala Ala Ile Ser Ala Leu Ile Met Ser 65 70 7580Ala Gly Val Val Trp Thr Ser Arg Lys Ser Ser Leu Ser Gln Asp Val

85 90 95Ser Ile Gly Leu Gln Phe Ile Thr Met Leu Ser Leu Gly Val Val Ile

100 105 110Val Ser His Ser Asp Ser His Ala Val Asp Leu Thr Ser Phe Leu Phe

115 120 125Gly Asp Ile Leu Gly Val Arg Pro Ser Asp Ile Phe Ile Ile Ala Ile

130 135 140Ala Thr Val Leu Gly Gly Leu Thr Ile Phe Leu Phe His Arg Gln Phe145 150 155 160Thr Ala Leu Ala Phe Asp Glu Arg Lys Ala His Thr Leu Gly Leu Asn

165 170 175Pro Arg Phe Ala His Leu Leu Met Leu Ala Leu Ile Ala Leu Ala Thr

180 185 190Val Val Ser Phe Gln Val Val Gly Thr Leu Leu Val Phe Gly Leu Leu

195 200 205Ile Gly Pro Pro Ala Thr Ala Ala Leu Leu Val Gln Asp Lys Ala Ser

210 215 220Ile Ser Leu Ile Met Ile Val Ala Ser Leu Leu Gly Cys Ala Glu Ile225 230 235 240Tyr Leu Gly Leu Leu Ile Ser Trp His Ala Ser Thr Ala Ala Gly Ala

245 250 255Thr Ile Thr Leu Leu Ser Ala Ala Ile Phe Phe Ala Thr Leu Leu Thr

260 265 270Lys Ser Ala Ile Ser Arg Leu Asn Phe Thr Ala

275280<210>589<211>1077<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1054)<223>RXN02443<400>589caagcactgc cgcgggagcc actatcactt tgttaagtgc tgcgatattt tttgccacct 60tattgacaaa gagtgccatt agtaggttaa acttcaccgc gtg ata ctg aaa gac 115

Val Ile Leu Lys Asp

1 5att ttc aat aat ggg gag ctc ttt ggg gct tcc tcc gcg aaa aat ttc 163Ile Phe Asn Asn Gly Glu Leu Phe Gly Ala Ser Ser Ala Lys Asn Phe

10 15 20cga aaa cta cta gct gtt cca gcc gtt gcc gcc tca cta gct ttt ggt 211Arg Lys Leu Leu Ala Val Pro Ala Val Ala Ala Ser Leu Ala Phe Gly

25 30 35atc acc gcc tgt tcc gct gta gat gac acc cct gac att gtg gtc acc 259Ile Thr Ala Cys Ser Ala Val Asp Asp Thr Pro Asp Ile Val Val Thr

40 45 50acc aac atc ctg ggt gat gtt gta agc cat atc gtg gga gat tcc gca 307Thr Asn Ile Leu Gly Asp Val Val Ser His Ile Val Gly Asp Ser Ala

55 60 65gat gtc caa gta ctc atg aaa ccc aac gca gat cca cat tcc ttc gga 355Asp Val Gln Val Leu Met Lys Pro Asn Ala Asp Pro His Ser Phe Gly 70 75 80 85gtc tca gca caa gac gcc gct gcc atg gaa cat gcc gat ctc atc gtg 403Val Ser Ala Gln Asp Ala Ala Ala Met Glu His Ala Asp Leu Ile Val

90 95 100gcc aat gga cta gga ctt gaa gag ggc ctt caa tcc aat gtg gac aat 451Ala Asn Gly Leu Gly Leu Glu Glu Gly Leu Gln Ser Asn Val Asp Asn

105 110 115gcc aaa agc caa ggg gtt ccc gtc ttg gaa gtc ggc gaa cac atc gat 499Ala Lys Ser Gln Gly Val Pro Val Leu Glu Val Gly Glu His Ile Asp

120 125 130gtc att gac tac tcc ccc ggc gtt cca gat cct cac ttt tgg aca gac 547Val Ile Asp Tyr Ser Pro Gly Val Pro Asp Pro His Phe Trp Thr Asp

135 140 145ccg gcg cgc atg atc gcc gcc acg gaa gtt ata gaa gct gaa ctg atc 595Pro Ala Arg Met Ile Ala Ala Thr Glu Val Ile Glu Ala Glu Leu Ile150 155 160 165aaa gaa ctc gat cct tcc ctg act gaa tcg atc aca caa tca gcc cag 643Lys Glu Leu Asp Pro Ser Leu Thr Glu Ser Ile Thr Gln Ser Ala Gln

170 175 180cac tac cgt gag gaa ctt gtt gcc ctt gat gag gaa gtc acc gaa ttg 691His Tyr Arg Glu Glu Leu Val Ala Leu Asp Glu Glu Val Thr Glu Leu

185 190 195ctc agc ggc gtg gcc cca gaa aac cgc aag ctg gta acc aat cac aat 739Leu Ser Gly Val Ala Pro Glu Asn Arg Lys Leu Val Thr Asn His Asn

200 205 210gtt ttt gga tac ctg gcc agc cgg ttt aac tac acc gtc att gac acc 787Val Phe Gly Tyr Leu Ala Ser Arg Phe Asn Tyr Thr Val Ile Asp Thr

215 220 225atc atc cca ggt gga agc aca ttg gcg gcg cct tca gca tct gac ctc 835Ile Ile Pro Gly Gly Ser Thr Leu Ala Ala Pro Ser Ala Ser Asp Leu230 235 240 245aat gac atc tcc acc gcc atc gaa gac aac aat gtt ccc gca atc ttc 883Asn Asp Ile Ser Thr Ala Ile Glu Asp Asn Asn Val Pro Ala Ile Phe

250 255 260acc gat acc tca agc cca caa cgg tta gct gaa gtg ttg gcc agc aac 931Thr Asp Thr Ser Ser Pro Gln Arg Leu Ala Glu Val Leu Ala Ser Asn

265 270275gct ggc att gat gtt caa gtg gtg tcc att ttc acg gaa tca ctc acc 979Ala Gly Ile Asp Val Gln Val Val Ser Ile Phe Thr Glu Ser Leu Thr

280 285 290gat gca gat ggt gaa gca ccc acc tac atc agc atg caa aaa atc aat 1027Asp Ala Asp Gly Glu Ala Pro Thr Tyr Ile Ser Met Gln Lys Ile Asn

295300305 gcc gag cgc att gca agc act ttg tcc taaacagtcc taaacagtct 1074Ala Glu Arg Ile Ala Ser Thr Leu Ser 310315 taa1077<210>590<211>318<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>590Val Ile Leu Lys Asp Ile Phe Asn Asn Gly Glu Leu Phe Gly Ala Ser 151015 Ser Ala Lys Asn Phe Arg Lys Leu Leu Ala Val Pro Ala Val Ala Ala

20 25 30Ser Leu Ala Phe Gly Ile Thr Ala Cys Ser Ala Val Asp Asp Thr Pro

35 40 45Asp Ile Val Val Thr Thr Asn Ile Leu Gly Asp Val Val Ser His Ile

50 55 60Val Gly Asp Ser Ala Asp Val Gln Val Leu Met Lys Pro Asn Ala Asp 65 70 75 80Pro His Ser Phe Gly Val Ser Ala Gln Asp Ala Ala Ala Met Glu His

85 90 95Ala Asp Leu Ile Val Ala Asn Gly Leu Gly Leu Glu Glu Gly Leu Gln

100 105 110Ser Asn Val Asp Asn Ala Lys Ser Gln Gly Val Pro Val Leu Glu Val

115 120 125Gly Glu His Ile Asp Val Ile Asp Tyr Ser Pro Gly Val Pro Asp Pro

130 135 140His Phe Trp Thr Asp Pro Ala Arg Met Ile Ala Ala Thr Glu Val Ile145 150 155 160Glu Ala Glu Leu Ile Lys Glu Leu Asp Pro Ser Leu Thr Glu Ser Ile

165 170 175Thr Gln Ser Ala Gln His Tyr Arg Glu Glu Leu Val Ala Leu Asp Glu

180 185 190Glu Val Thr Glu Leu Leu Ser Gly Val Ala Pro Glu Asn Arg Lys Leu

195 200 205Val Thr Asn His Asn Val Phe Gly Tyr Leu Ala Ser Arg Phe Asn Tyr

210 215 220Thr Val Ile Asp Thr Ile Ile Pro Gly Gly Ser Thr Leu Ala Ala Pro225 230 235 240Ser Ala Ser Asp Leu Asn Asp Ile Ser Thr Ala Ile Glu Asp Asn Asn

245 250 255Val Pro Ala Ile Phe Thr Asp Thr Ser Ser Pro Gln Arg Leu Ala Glu

260 265 270Val Leu Ala Ser Asn Ala Gly Ile Asp Val Gln Val Val Ser Ile Phe

275 280 285Thr Glu Ser Leu Thr Asp Ala Asp Gly Glu Ala Pro Thr Tyr Ile Ser

290295300 Met Gln Lys Ile Asn Ala Glu Arg Ile Ala Ser Thr Leu Ser 305310315<210>591<211>1323<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1300)<223>RXN00842<400>591ccttgtcgcg gaggtaagcg agggtatttc tggatgtgga acaacgcgga ttatggaaaa 60tcgtgacttt cataacgttg agcctactaa ggtttgttcc atg att att caa atc 115

Met Ile Ile Gln Ile

1 5cta aga gtg gca ttt gcc ttc gtc ggc atc att gtt ggc gcc ggt ttc 163Leu Arg Val Ala Phe Ala Phe Val Gly Ile Ile Val Gly Ala Gly Phe

10 15 20gca tca ggg caa gag gtc atg caa tat ttt gtg gcc ttc ggc ata gac 211Ala Ser Gly Gln Glu Val Met Gln Tyr Phe Val Ala Phe Gly Ile Asp

25 30 35gga att tgg gga gtc att gtt tct gca gtg atc atg tcg gtg atg gcg 259Gly Ile Trp Gly Val Ile Val Ser Ala Val Ile Met Ser Val Met Ala

40 45 50ttg atc att ttg cag ctc gga agc tat ttc aat gca ggt gaa cac ggt 307Leu Ile Ile Leu Gln Leu Gly Ser Tyr Phe Asn Ala Gly Glu His Gly

55 60 65gaa gtg ttc cgc cga gta agt cac ccc gtt ttc tcc aaa att ttg gac 355Glu Val Phe Arg Arg Val Ser His Pro Val Phe Ser Lys Ile Leu Asp 70 75 80 85atc ggc gtt gtg gtg acg ttg ttc tcc acc ggt ttc gtc atg ttt gca 403Ile Gly Val Val Val Thr Leu Phe Ser Thr Gly Phe Val Met Phe Ala

90 95 100ggc gcg gga tca aat ctg aat cag cag tgg ggg ctt ccg ctc tgg atc 451Gly Ala Gly Ser Asn Leu Asn Gln Gln Trp Gly Leu Pro Leu Trp Ile

105 110 115ggt tct gtg atc atg gtt ctt ctg gtg ctg gct gcg ggc atg ttg gac 499Gly Ser Val Ile Met Val Leu Leu Val Leu Ala Ala Gly Met Leu Asp

120 125 130gtg gat aaa gta acc aca gtc att ggt gca att act ccg ttc atc atc 547Val Asp Lys Val Thr Thr Val Ile Gly Ala Ile Thr Pro Phe Ile Ile

135 140 145att ttc atc act gcc gcc tcg atc tac acg ctg gta ggt aat ttc agc 595Ile Phe Ile Thr Ala Ala Ser Ile Tyr Thr Leu Val Gly Asn Phe Ser150 155 160 165tca gtg gag cag ctt gat tct gct gct tta gaa gtc ggc acg acg ttg 643Ser Val Glu Gln Leu Asp Ser Ala Ala Leu Glu Val Gly Thr Thr Leu

170 175 180cct cac tgg gct gtt gca gcg gtg aac tat gtg gga ttc aac ctg atg 691Pro His Trp Ala Val Ala Ala Val Asn Tyr Val Gly Phe Asn Leu Met

185 190 195gtt gcg gtg tcc atg gct gtg gtc att ggt gga tca atg ttt aac ccg 739Val Ala Val Ser Met Ala Val Val Ile Gly Gly Ser Met Phe Asn Pro

200 205 210cgg gtc gca ggt cgg ggc ggt ttg ctg ggc gga ttg atc ctg gga ttc 787Arg Val Ala Gly Arg Gly Gly Leu Leu Gly Gly Leu Ile Leu Gly Phe

215 220 225ttg atc atc atc agt gcg cta aca ctg ttc gcc acc gtg gaa gaa gtt 835Leu Ile Ile Ile Ser Ala Leu Thr Leu Phe Ala Thr Val Glu Glu Val230 235 240 245ggc caa gat gat atg cct atg ctg acg atc atc aac aat ttg aac ccg 883Gly Gln Asp Asp Met Pro Met Leu Thr Ile Ile Asn Asn Leu Asn Pro

250 255 260ctg gct ggc caa gta atg gca gtg gtt atc tac gga atg atc ttc aac 931Leu Ala Gly Gln Val Met Ala Val Val Ile Tyr Gly Met Ile Phe Asn

265 270 275acg gca ctg ggt atg ttc tac gca ttg ggc cgt cgt ctc act gcg aaa 979Thr Ala Leu Gly Met Phe Tyr Ala Leu Gly Arg Arg Leu Thr Ala Lys

280 285 290aac cca cag cga ttc cgt ccg gtt tat gtg gtc aca gtg ctg att ggt 1027Asn Pro Gln Arg Phe Arg Pro Val Tyr Val Val Thr Val Leu Ile Gly

295 300 305ttt gtg ttg agc ttt gtg gga ttc aag aac ttg gtg ggc tat gtg tac 1075Phe Val Leu Ser Phe Val Gly Phe Lys Asn Leu Val Gly Tyr Val Tyr310 315 320 325cca gtc ttg gga tac att ggc ctg ctg ctg att gca gtg atg atg gtg 1123Pro Val Leu Gly Tyr Ile Gly Leu Leu Leu Ile Ala Val Met Met Val

330 335 340gcg tgg gtg agg gga cgc gta cgc atc tac aag gaa tcc gaa cgc cgc 1171Ala Trp Val Arg Gly Arg Val Arg Ile Tyr Lys Glu Ser Glu Arg Arg

345 350 355atg cgg atc gca gac ttg ttg cag atc ggc cat gac gga gcg ttg agt 1219Met Arg Ile Ala Asp Leu Leu Gln Ile Gly His Asp Gly Ala Leu Ser

360 365 370gga gca gag ctg gcg gtg ctc aac cag gaa atc caa gat tca aac ttg 1267Gly Ala Glu Leu Ala Val Leu Asn Gln Glu Ile Gln Asp Ser Asn Leu

375380385 gat gag gaa caa att aaa gca gcg gtt agg aag tagttactct gcagggacga 1320Asp Glu Glu Gln Ile Lys Ala Ala Val Arg Lys 390395400 gct1323<210>592<211>400<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>592Met Ile Ile Gln Ile Leu Arg Val Ala Phe Ala Phe Val Gly Ile Ile 151015 Val Gly Ala Gly Phe Ala Ser Gly Gln Glu Val Met Gln Tyr Phe Val

20 25 30Ala Phe Gly Ile Asp Gly Ile Trp Gly Val Ile Val Ser Ala Val Ile

35 40 45Met Ser Val Met Ala Leu Ile Ile Leu Gln Leu Gly Ser Tyr Phe Asn

50 55 60Ala Gly Glu His Gly Glu Val Phe Arg Arg Val Ser His Pro Val Phe 65 70 75 80Ser Lys Ile Leu Asp Ile Gly Val Val Val Thr Leu Phe Ser Thr Gly

85 90 95Phe Val Met Phe Ala Gly Ala Gly Ser Asn Leu AsnGln Gln Trp Gly

100 105 110Leu Pro Leu Trp Ile Gly Ser Val Ile Met Val Leu Leu Val Leu Ala

115 120 125Ala Gly Met Leu Asp Val Asp Lys Val Thr Thr Val Ile Gly Ala Ile

130 135 140Thr Pro Phe Ile Ile Ile Phe Ile Thr Ala Ala Ser Ile Tyr Thr Leu145 150 155 160Val Gly Asn Phe Ser Ser Val Glu Gln Leu Asp Ser Ala Ala Leu Glu

165 170 175Val Gly Thr Thr Leu Pro His Trp Ala Val Ala Ala Val Asn Tyr Val

180 185 190Gly Phe Asn Leu Met Val Ala Val Ser Met Ala Val Val Ile Gly Gly

195 200 205Ser Met Phe Asn Pro Arg Val Ala Gly Arg Gly Gly Leu Leu Gly Gly

210 215 220Leu Ile Leu Gly Phe Leu Ile Ile Ile Ser Ala Leu Thr Leu Phe Ala225 230 235 240Thr Val Glu Glu Val Gly Gln Asp Asp Met Pro Met Leu Thr Ile Ile

245 250 255Asn Asn Leu Asn Pro Leu Ala Gly Gln Val Met Ala Val Val Ile Tyr

260 265 270Gly Met Ile Phe Asn Thr Ala Leu Gly Met Phe Tyr Ala Leu Gly Arg

275 280 285Arg Leu Thr Ala Lys Asn Pro Gln Arg Phe Arg Pro Val Tyr Val Val

290 295 300Thr Val Leu Ile Gly Phe Val Leu Ser Phe Val Gly Phe Lys Asn Leu305 310 315 320Val Gly Tyr Val Tyr Pro Val Leu Gly Tyr Ile Gly Leu Leu Leu Ile

325 330 335Ala Val Met Met Val Ala Trp Val Arg Gly Arg Val Arg Ile Tyr Lys

340 345 350Glu Ser Glu Arg Arg Met Arg Ile Ala Asp Leu Leu Gln Ile Gly His

355 360 365Asp Gly Ala Leu Ser Gly Ala Glu Leu Ala Val Leu Asn Gln Glu Ile

370375380 Gln Asp Ser Asn Leu Asp Glu Glu Gln Ile Lys Ala Ala Val Arg Lys 385390395400<210>593<211>1323<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1300)<223>FRXA00842<400>593ccttgtcgcg gaggtaagcg agggtatttc tggatgtgga acaacgcgga ttatggaaaa 60tcgtgacttt cataacgttg agcctactaa ggtttgttcc atg att att caa atc 115

Met Ile Ile Gln Ile

1 5cta aga gtg gca ttt gcc ttc gtc ggc atc att gtt ggc gcc ggt ttc 163Leu Arg Val Ala Phe Ala Phe Val Gly Ile Ile Val Gly Ala Gly Phe

10 15 20gca tca ggg caa gag gtc atg caa tat ttt gtg gcc ttc ggc ata gac 211Ala Ser Gly Gln Glu Val Met Gln Tyr Phe Val Ala Phe Gly Ile Asp

25 30 35gga att tgg gga gtc att gtt tct gca gtg atc atg tcg gtg atg gcg 259Gly Ile Trp Gly Val Ile Val Ser Ala Val Ile Met Ser Val Met Ala

40 45 50ttg atc att ttg cag ctc gga agc tat ttc aat gca ggt gaa cac ggt 307Leu Ile Ile Leu Gln Leu Gly Ser Tyr Phe Asn Ala Gly Glu His Gly

55 60 65gaa gtg ttc cgc cga gta agt cac ccc gtt ttctcc aaa att ttg gac 355Glu Val Phe Arg Arg Val Ser His Pro Val Phe Ser Lys Ile Leu Asp 70 75 80 85atc ggc gtt gtg gtg acg ttg ttc tcc acc ggt ttc gtc atg ttt gca 403Ile Gly Val Val Val Thr Leu Phe Ser Thr Gly Phe Val Met Phe Ala

90 95 100ggc gcg gga tca aat ctg aat cag cag tgg ggg ctt ccg ctc tgg atc 451Gly Ala Gly Ser Asn Leu Asn Gln Gln Trp Gly Leu Pro Leu Trp Ile

105 110 115ggt tct gtg atc atg gtt ctt ctg gtg ctg gct gcg ggc atg ttg gac 499Gly Ser Val Ile Met Val Leu Leu Val Leu Ala Ala Gly Met Leu Asp

120 125 130gtg gat aaa gta acc aca gtc att ggt gca att act ccg ttc atc atc 547Val Asp Lys Val Thr Thr Val Ile Gly Ala Ile Thr Pro Phe Ile Ile

135 140 145att ttc atc act gcc gcc tcg atc tac acg ctg gta ggt aat ttc agc 595Ile Phe Ile Thr Ala Ala Ser Ile Tyr Thr Leu Val Gly Asn Phe Ser150 155 160 165tca gtg gag cag ctt gat tct gct gct tta gaa gtc ggc acg acg ttg 643Ser Val Glu Gln Leu Asp Ser Ala Ala Leu Glu Val Gly Thr Thr Leu

170 175 180cct cac tgg gct gtt gca gcg gtg aac tat gtg gga ttc aac ctg atg 691Pro His Trp Ala Val Ala Ala Val Asn Tyr Val Gly Phe Asn Leu Met

185 190 195gtt gcg gtg tcc atg gct gtg gtc att ggt gga tca atg ttt aac ccg 739Val Ala Val Ser Met Ala Val Val Ile Gly Gly Ser Met Phe Asn Pro

200 205 210cgg gtc gca ggt cgg ggc ggt ttg ctg ggc gga ttg atc ctg gga ttc 787Arg Val Ala Gly Arg Gly Gly Leu Leu Gly Gly Leu Ile Leu Gly Phe

215 220 225ttg arc atc atc agt gcg cta aca ctg ttc gcc acc gtg gaa gaa gtt 835Leu Ile Ile Ile Ser Ala Leu Thr Leu Phe Ala Thr Val Glu Glu Val230 235 240 245ggc caa gat gat atg cct atg ctg acg atc atc aac aat ttg aac ccg 883Gly Gln Asp Asp Met Pro Met Leu Thr Ile Ile Asn Asn Leu Asn Pro

250 255 260ctg gct ggc caa gta atg gca gtg gtt atc tac gga atg atc ttc aac 931Leu Ala Gly Gln Val Met Ala Val Val Ile Tyr Gly Met Ile Phe Asn

265 270 275acg gca ctg ggt atg ttc tac gca ttg ggc cgt cgt ctc act gcg aaa 979Thr Ala Leu Gly Met Phe Tyr Ala Leu Gly Arg Arg Leu Thr Ala Lys

280 285 290aac cca cag cga ttc cgt ccg gtt tat gtg gtc aca gtg ctg att ggt 1027Asn Pro Gln Arg Phe Arg Pro Val Tyr Val Val Thr Val Leu Ile Gly

295 300 305ttt gtg ttg agc ttt gtg gga ttc aag aac ttg gtg ggc tat gtg tac 1075Phe Val Leu Ser Phe Val Gly Phe Lys Asn Leu Val Gly Tyr Val Tyr310 315 320 325cca gtc ttg gga tac att ggc ctg ctg ctg att gca gtg atg atg gtg 1123Pro Val Leu Gly Tyr Ile Gly Leu Leu Leu Ile Ala Val Met Met Val

330 335 340gcg tgg gtg agg gga cgc gta cgc atc tac aag gaa tcc gaa cgc cgc 1171Ala Trp Val Arg Gly Arg Val Arg Ile Tyr Lys Glu Ser Glu Arg Arg

345 350 355atg cgg atc gca gac ttg ttg cag atc ggc cat gac gga gcg ttg agt 1219Met Arg Ile Ala Asp Leu Leu Gln Ile Gly His Asp Gly Ala Leu Ser

360 365 370gga gca gagctg gcg gtg ctc aac cag gaa atc caa gat tca aac ttg 1267Gly Ala Glu Leu Ala Val Leu Asn Gln Glu Ile Gln Asp Ser Asn Leu

375380385 gat gag gaa caa att aaa gca gcg gtt agg aag tagttactct gcagggacga 1320Asp Glu Glu Gln Ile Lys Ala Ala Val Arg Lys 390395400 gct1323<210>594<211>400<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>594Met Ile Ile Gln Ile Leu Arg Val Ala Phe Ala Phe Val Gly Ile Ile 151015 Val Gly Ala Gly Phe Ala Ser Gly Gln Glu Val Met Gln Tyr Phe Val

20 25 30Ala Phe Gly Ile Asp Gly Ile Trp Gly Val Ile Val Ser Ala Val Ile

35 40 45Met Ser Val Met Ala Leu Ile Ile Leu Gln Leu Gly Ser Tyr Phe Asn

50 55 60Ala Gly Glu His Gly Glu Val Phe Arg Arg Val Ser His Pro Val Phe 65 70 75 80Ser Lys Ile Leu Asp Ile Gly Val Val Val Thr Leu Phe Ser Thr Gly

85 90 95Phe Val Met Phe Ala Gly Ala Gly Ser Asn Leu Asn Gln Gln Trp Gly

100 105 110Leu Pro Leu Trp Ile Gly Ser Val Ile Met Val Leu Leu Val Leu Ala

115 120 125Ala Gly Met Leu Asp Val Asp Lys Val Thr Thr Val Ile Gly Ala Ile

130 135 140Thr Pro Phe Ile Ile Ile Phe Ile Thr Ala Ala Ser Ile Tyr Thr Leu145 150 155 160Val Gly Asn Phe Ser Ser Val Glu Gln Leu Asp Ser Ala Ala Leu Glu

165 170 175Val Gly Thr Thr Leu Pro His Trp Ala Val Ala Ala Val Asn Tyr Val

180 185 190Gly Phe Asn Leu Met Val Ala Val Ser Met Ala Val Val Ile Gly Gly

195 200 205Ser Met Phe Asn Pro Arg Val Ala Gly Arg Gly Gly Leu Leu Gly Gly

210 215 220Leu Ile Leu Gly Phe Leu Ile Ile Ile Ser Ala Leu Thr Leu Phe Ala225 230 235 240Thr Val Glu Glu Val Gly Gln Asp Asp Met Pro Met Leu Thr Ile Ile

245 250 255Asn Asn Leu Asn Pro Leu Ala Gly Gln Val Met Ala Val Val Ile Tyr

260 265 270Gly Met Ile Phe Asn Thr Ala Leu Gly Met Phe Tyr Ala Leu Gly Arg

275 280 285Arg Leu Thr Ala Lys Asn Pro Gln Arg Phe Arg Pro Val Tyr Val Val

290 295 300Thr Val Leu Ile Gly Phe Val Leu Ser Phe Val Gly Phe Lys Asn Leu305 310 315 320Val Gly Tyr Val Tyr Pro Val Leu Gly Tyr Ile Gly Leu Leu Leu Ile

325 330 335Ala Val Met Met Val Ala Trp Val Arg Gly Arg Val Arg Ile Tyr Lys

340 345 350Glu Ser Glu Arg Arg Met Arg Ile Ala Asp Leu Leu Gln Ile Gly His

355 360 365Asp Gly Ala Leu Ser Gly Ala Glu Leu Ala Val Leu Asn Gln Glu Ile

370375380 Gln Asp Ser Asn Leu Asp Glu Glu Gln Ile Lys Ala Ala Val Arg Lys 385390395400<210>595<211>1173<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101) }, (1150)<223>RXN00832<400>595gagattgtgc taggttctga tgaggcttcg ggacgacccg aagaaatcta tgacagcctg 60ggaacggccc agagttctta agaaagtttg actagagaac atg ccg ttt tct tgg 115

Met Pro Phe Ser Trp

1 5cta aaa cca att gat tat gcc cgc atc ttt gtc ggc tgg gca tcg att 163Leu Lys Pro Ile Asp Tyr Ala Arg Ile Phe Val Gly Trp Ala Ser Ile

10 15 20ttt atc atc ccc ctc atc aca ctg cca tca att att gag ttg gcg ctg 211Phe Ile Ile Pro Leu Ile Thr Leu Pro Set Ile Ile Glu Leu Ala Leu

25 30 35atc gtg gca gtc atc cta ttc tgc gca ttt ggc gtg gtg aag atg gcg 259Ile Val Ala Val Ile Leu Phe Cys Ala Phe Gly Val Val Lys Met Ala

40 45 50gag cgt ttg gct cat att ttg ggt gat cct ttt gga tcg ttg atc ctt 307Glu Arg Leu Ala His Ile Leu Gly Asp Pro Phe Gly Ser Leu Ile Leu

55 60 65acc ttg tcg atc gtg atc att gaa gtg att ttg atc tgt gcg gtg atg 355Thr Leu Ser Ile Val Ile Ile Glu Val Ile Leu Ile Cys Ala Val Met 70 75 80 85ctg ggg cct gct gat tca acc act gct ggt cgg gat tcc gtg atg gca 403Leu Gly Pro Ala Asp Ser Thr Thr Ala Gly Arg Asp Ser Val Met Ala

90 95 100gtg tcc atg atc atc atg ggt ttg gtc gtg gga ttg tgc cta ctc att 451Val Ser Met Ile Ile Met Gly Leu Val Val Gly Leu Cys Leu Leu Ile

105 110 115ggt ggt tta agg cat gga agc atg cca cac aat ggg gtg gga act ccg 499Gly Gly Leu Arg His Gly Ser Met Pro His Asn Gly Val Gly Thr Pro

120 125 130acc tac ttg gtg ctg atc gca act ttt tcc gta atc gcc ttt gcg gtt 547Thr Tyr Leu Val Leu Ile Ala Thr Phe Ser Val Ile Ala Phe Ala Val

135 140 145cca gct ttc agg gga gaa tac tcc act ggg cag gca ctt gtt att tca 595Pro Ala Phe Arg Gly Glu Tyr Ser Thr Gly Gln Ala Leu Val Ile Ser150 155 160 165aca ctg aca gca gtg gtg tac ggg ttc ttc ctg ttt cgc caa atg ggt 643Thr Leu Thr Ala Val Val Tyr Gly Phe Phe Leu Phe Arg Gln Met Gly

170 175 180gcc caa gct ggt gaa ttt caa gag gtc gag gtc gca gaa aag gca gac 691Ala Gln Ala Gly Glu Phe Gln Glu Val Glu Val Ala Glu Lys Ala Asp

185 190 195gac gca gca aaa tgg gag gtc cca ttt aga ggc tta atc ttg att atc 739Asp Ala Ala Lys Trp Glu Val Pro Phe Arg Gly Leu Ile Leu Ile Ile

200 205 210act gtg ctc ccc atc gtg ttg ctg tcc cat gac atg gcc acg gtg atg 787Thr Val Leu Pro Ile Val Leu Leu Ser His Asp Met Ala Thr Val Met

215 220 225gat gaa gtc ctg gca agc ctt ggt gca ccc gta gca atg gct gga tta 835Asp Glu Val Leu Ala Ser Leu Gly Ala Pro Val Ala Met Ala Gly Leu230 235 240 245att att gcc acc att gtc ttc ttg cca gag acc atc acc tcc ttg aaa 883Ile Ile Ala Thr Ile Val Phe Leu Pro Glu Thr Ile Thr Ser Leu Lys

250 255 260gct gcg tgg aca gga gag att cag cga gta agc aac ctc gcg cat gga 931Ala Ala Trp Thr Gly Glu Ile Gln Arg Val Ser Asn Leu Ala His Gly

265 270 275gcc caa gta tca acg gtg ggg ctg aca atc ccagct gtt cta gtg atc 979Ala Gln Val Ser Thr Val Gly Leu Thr Ile Pro Ala Val Leu Val Ile

280 285 290ggc gtg atc aca ggt caa gat gta gtt ttg ggg gag acc ccg atc aac 1027Gly Val Ile Thr Gly Gln Asp Val Val Leu Gly Glu Thr Pro Ile Asn

295 300 305ttg ttg ctg ctg gga acc acc att gcg gtg aca gcc att gcg ttt agc 1075Leu Leu Leu Leu Gly Thr Thr Ile Ala Val Thr Ala Ile Ala Phe Ser310 315 320 325tcc aag aaa gtc agt gct gtg cat ggc tcg gtg ctg ctc atg ctt ttc 1123Ser Lys Lys Val Ser Ala Val His Gly Ser Val Leu Leu Met Leu Phe

330 335 340ggt gtt tac atg atg agc atg ttc gcc tgatttaggt agcctggtgg 1170Gly Val Tyr Met Met Ser Met Phe Ala

345350 gaa1173<210>596<211>350<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>596Met Pro Phe Ser Trp Leu Lys Pro Ile Asp Tyr Ala Arg Ile Phe Val l 51015 Gly Trp Ala Ser Ile Phe Ile Ile Pro Leu Ile Thr Leu Pro Ser Ile

20 25 30Ile Glu Leu Ala Leu Ile Val Ala Val Ile Leu Phe Cys Ala Phe Gly

35 40 45Val Val Lys Met Ala Glu Arg Leu Ala His Ile Leu Gly Asp Pro Phe

50 55 60Gly Ser Leu Ile Leu Thr Leu Ser Ile Val Ile Ile Glu Val Ile Leu65 70 75 80Ile Cys Ala Val Met Leu Gly Pro Ala Asp Ser Thr Thr Ala Gly Arg

85 90 95Asp Ser Val Met Ala Val Ser Met Ile Ile Met Gly Leu Val Val Gly

100 105 110Leu Cys Leu Leu Ile Gly Gly Leu Arg His Gly Ser Met Pro His Asn

115 120 125Gly Val Gly Thr Pro Thr Tyr Leu Val Leu Ile Ala Thr Phe Ser Val

130 135 140Ile Ala Phe Ala Val Pro Ala Phe Arg Gly Glu Tyr Ser Thr Gly Gln145 150 155 160Ala Leu Val Ile Ser Thr Leu Thr Ala Val Val Tyr Gly Phe Phe Leu

165 170 175Phe Arg Gln Met Gly Ala Gln Ala Gly Glu Phe Gln Glu Val Glu Val

180 185 190Ala Glu Lys Ala Asp Asp Ala Ala Lys Trp Glu Val Pro Phe Arg Gly

195 200 205Leu Ile Leu Ile Ile Thr Val Leu Pro Ile Val Leu Leu Ser His Asp

210 215 220Met Ala Thr Val Met Asp Glu Val Leu Ala Ser Leu Gly Ala Pro Val225 230 235 240Ala Met Ala Gly Leu Ile Ile Ala Thr Ile Val Phe Leu Pro Glu Thr

245 250 255Ile Thr Ser Leu Lys Ala Ala Trp Thr Gly Glu Ile Gln Arg Val Ser

260 265 270Asn Leu Ala His Gly Ala Gln Val Ser Thr Val Gly Leu Thr Ile Pro

275 280 285Ala Val Leu Val Ile Gly Val Ile Thr Gly Gln Asp Val Val Leu Gly

290 295 300Glu Thr Pro Ile Asn Leu Leu Leu Leu Gly Thr Thr Ile Ala Val Thr305 310 315 320Ala Ile Ala Phe Ser Ser Lys Lys Val Ser Ala Val His Gly Ser Val

325 330 335Leu Leu Met Leu Phe Gly Val Tyr Met Met Ser Met Phe Ala

340345350<210>597<211>1119<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1096)<223>RXN00466<400>597tttaaaagcg cactaagagc tcgtcaattc tttaaaacaa gctgagaatg tgaataatag 60gataggttaa cctgattcga ttagaaaacg gagatttgtc gtg caa tcc cgc ctg 115

Val Gln Ser Arg Leu

1 5tcc aaa atc ctg cgc agt agc gtc gta ggc gtt gct gtc cta gcc ctg 163Ser Lys Ile Leu Arg Ser Ser Val Val Gly Val Ala Val Leu Ala Leu

10 15 20tta gct ggg tgt tct aac aat gca gat gac acc gac gct gat tca aca 211Leu Ala Gly Cys Ser Asn Asn Ala Asp Asp Thr Asp Ala Asp Ser Thr

25 30 35tcc acg gga aac tcc gct ttt cct gtt tcg att gaa cac gag ttc gga 259Ser Thr Gly Asn Ser Ala Phe Pro Val Ser Ile Glu His Glu Phe Gly

40 45 50acc acc aca atc gat gat gta ccc gaa aga gtt gtc acc ctt ggc gtt 307Thr Thr Thr Ile Asp Asp Val Pro Glu Arg Val Val Thr Leu Gly Val

55 60 65acc gac gcc gat att gtc ctc gca ttg ggg acc gtc cca gta ggc aac 355Thr Asp Ala Asp Ile Val Leu Ala Leu Gly Thr Val Pro Val Gly Asn 70 75 80 85acc gga tac aaa ttc ttc gaa aac gga ttg gga ccg tgg act gat gag 403Thr Gly Tyr Lys Phe Phe Glu Asn Gly Leu Gly Pro Trp Thr Asp Glu

90 95 100tta gtg gaa ggc aaa gaa tta aca ctg ctt gac tct gat tcc aca cca 451Leu Val Glu Gly Lys Glu Leu Thr Leu Leu Asp Ser Asp Ser Thr Pro

105 110 115gat ctt gaa caa gta gca gcc ctg gag cca gac ctg att att gga gtc 499Asp Leu Glu Gln Val Ala Ala Leu Glu Pro Asp Leu Ile Ile Gly Val

120 125 130tct gcg ggg ttt gac gac gtt gta tac gag caa cta tct gat atc gca 547Ser Ala Gly Phe Asp Asp Val Val Tyr Glu Gln Leu Ser Asp Ile Ala

135 140 145ccg gtg gtc gcc cgt cca gcg gga aca gct gca tac gca gta gct cgc 595Pro Val Val Ala Arg Pro Ala Gly Thr Ala Ala Tyr Ala Val Ala Arg150 155 160 165gag gaa gct acc aac ctt gtt gcc cgt gcg atg ggg caa tca gaa aaa 643Glu Glu Ala Thr Asn Leu Val Ala Arg Ala Met Gly Gln Ser Glu Lys

170 175 180gga caa gag ctc aat gag gaa aca gat gct ctg atc caa gct gcg cgt 691Gly Gln Glu Leu Asn Glu Glu Thr Asp Ala Leu Ile Gln Ala Ala Arg

185 190 195gat gaa aat cct tct ttt gac ggt aaa aca gga acc gtc atc ttg cca 739Asp Glu Asn Pro Ser Phe Asp Gly Lys Thr Gly Thr Val Ile Leu Pro

200 205 210tac cag ggt aaa tac ggt gcc tac ctg cca ggc gat gca cgg gga caa 787Tyr Gln Gly Lys Tyr Gly Ala Tyr Leu Pro Gly Asp Ala Arg Gly Gln

215 220 225ttc ctc gat tca ctt ggc att tcg ctg ccg gaa gca gtt ctt tcg cga 835Phe Leu Asp Ser Leu Gly Ile Ser Leu Pro Glu Ala Val Leu Ser Arg230 235 240 245gac acc ggc gac agc ttc ttt gtc gat gtc ccc gct gaa agc gtc aaa 883Asp Thr Gly Asp Ser Phe Phe Val Asp Val Pro Ala Glu Ser Val Lys

250255 260gac gta gac ggt gat gtt ctc ctc gtg ctt tcc aac gac gaa aat ctg 931Asp Val Asp Gly Asp Val Leu Leu Val Leu Ser Asn Asp Glu Asn Leu

265 270 275gat atc aca gca gag aat cca ctg ttt gaa aca ctc aac gtt gtg caa 979Asp Ile Thr Ala Glu Asn Pro Leu Phe Glu Thr Leu Asn Val Val Gln

280 285 290aaa gac gca gta att gtg gca aca acc gaa gaa cgc ggg gcg att acc 1027Lys Asp Ala Val Ile Val Ala Thr Thr Glu Glu Arg Gly Ala Ile Thr

295 300 305tac aac tca gtg ctg tct gtt cct ttt gcg ttg gaa cat ctc gca cca 1075Tyr Asn Ser Val Leu Ser Val Pro Phe Ala Leu Glu His Leu Ala Pro310 315 320 325cgt att gct gag gct ttg aag taaaactcaa ctactcgagc aca 1119Arg Ile Ala Glu Ala Leu Lys

330<210>598<211>332<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>598Val Gln Ser Arg Leu Ser Lys Ile Leu Arg Ser Ser Val Val Gly Val 151015 Ala Val Leu Ala Leu Leu Ala Gly Cys Ser Asn Asn Ala Asp Asp Thr

20 25 30Asp Ala Asp Ser Thr Ser Thr Gly Asn Ser Ala Phe Pro Val Ser Ile

35 40 45Glu His Glu Phe Gly Thr Thr Thr Ile Asp Asp Val Pro Glu Arg Val

50 55 60Val Thr Leu Gly Val Thr Asp Ala Asp Ile Val Leu Ala Leu Gly Thr 65 70 75 80Val Pro Val Gly Asn Thr Gly Tyr Lys Phe Phe Glu Asn Gly Leu Gly

85 90 95Pro Trp Thr Asp Glu Leu Val Glu Gly Lys Glu Leu Thr Leu Leu Asp

100 105 110Ser Asp Ser Thr Pro Asp Leu Glu Gln Val Ala Ala Leu Glu Pro Asp

115 120 125Leu Ile Ile Gly Val Ser Ala Gly Phe Asp Asp Val Val Tyr Glu Gln

130 135 140Leu Ser Asp Ile Ala Pro Val Val Ala Arg Pro Ala Gly Thr Ala Ala145 150 155 160Tyr Ala Val Ala Arg Glu Glu Ala Thr Asn Leu Val Ala Arg Ala Met

165 170 175Gly Gln Ser Glu Lys Gly Gln Glu Leu Asn Glu Glu Thr Asp Ala Leu

180 185 190Ile Gln Ala Ala Arg Asp Glu Asn Pro Ser Phe Asp Gly Lys Thr Gly

195 200 205Thr Val Ile Leu Pro Tyr Gln Gly Lys Tyr Gly Ala Tyr Leu Pro Gly

210 215 220Asp Ala Arg Gly Gln Phe Leu Asp Ser Leu Gly Ile Ser Leu Pro Glu225 230 235 240Ala Val Leu Ser Arg Asp Thr Gly Asp Ser Phe Phe Val Asp Val Pro

245 250 255Ala Glu Ser Val Lys Asp Val Asp Gly Asp Val Leu Leu Val Leu Ser

260 265 270Asn Asp Glu Asn Leu Asp Ile Thr Ala Glu Asn Pro Leu Phe Glu Thr

275 280 285Leu Asn Val Val Gln Lys Asp Ala Val Ile Val Ala Thr Thr Glu Glu

290 295 300Arg Gly Ala Ile Thr Tyr Asn Ser Val Leu Ser Val Pro Phe Ala Leu305 310 315 320Glu His Leu Ala Pro Arg Ile Ala Glu Ala Leu Lys

325330<210>599<211>1395<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1372)<223>RXN01936<400>599gcgcggtgac accacagccg ttgtcagcgg cgcttggtct gtggaggatc gccgaggtta 60ctaacaaata ggcccaacaa agaggtctaa gctctacctg gtg agt ttc cga gat 115

Val Ser Phe Arg Asp

1 5att ttc gct gac acc aga ccg ctg aaa gaa ccg gcc ttc aaa cgc ctc 163Ile Phe Ala Asp Thr Arg Pro Leu Lys Glu Pro Ala Phe Lys Arg Leu

10 15 20tgg ctt ggc aat gtt gcc acc gtc att ggt gcc caa tta act gtt gtt 211Trp Leu Gly Asn Val Ala Thr Val Ile Gly Ala Gln Leu Thr Val Val

25 30 35gcc gtt ccg gtg cag att tac caa atg act ggg tcc tcc ggc tat gtg 259Ala Val Pro Val Gln Ile Tyr Gln Met Thr Gly Ser Ser Gly Tyr Val

40 45 50ggc ttg acc ggg ctt ttt ggc ctt att cct ttg gtt att ttt ggc ctt 307Gly Leu Thr Gly Leu Phe Gly Leu Ile Pro Leu Val Ile Phe Gly Leu

55 60 65tat ggt gga tcc att gcg gat gct ttt gat aaa cgc atc gtg ctg atc 355Tyr Gly Gly Ser Ile Ala Asp Ala Phe Asp Lys Arg Ile Val Leu Ile 70 75 80 85tgc acc acg atc ggc atg tgt gtc acc act gcc ggt ttt tgg gtg ctg 403Cys Thr Thr Ile Gly Met Cys Val Thr Thr Ala Gly Phe Trp Val Leu

90 95 100acc att tta ggc aat gag aat att tgg ctc ctg tta ata aac ttt tct 451Thr Ile Leu Gly Asn Glu Asn Ile Trp Leu Leu Leu Ile Asn Phe Ser

105 110115tta cag cag gca ttt ttc gcg gtg aat caa ccc acc cga acg gcg atc 499Leu Gln Gln Ala Phe Phe Ala Val Asn Gln Pro Thr Arg Thr Ala Ile

120 125 130ctt cga agt att ttg ccg att gat caa tta gcg tcg gca aca tca ctg 547Leu Arg Ser Ile Leu Pro Ile Asp Gln Leu Ala Ser Ala Thr Ser Leu

135 140 145aat atg ctg ctc atg cag acc ggc gca atc gtt ggc ccg ctg atc gca 595Asn Met Leu Leu Met Gln Thr Gly Ala Ile Val Gly Pro Leu Ile Ala150 155 160 165ggt gcg ttg att ccg ctg atc ggt ttc ggg tgg ctg tat ttc ctt gat 643Gly Ala Leu Ile Pro Leu Ile Gly Phe Gly Trp Leu Tyr Phe Leu Asp

170 175 180gtt gtc tcc atc atc ccc aca ctg tgg gct gta tgg tca ctg cct tcg 691Val Val Ser Ile Ile Pro Thr Leu Trp Ala Val Trp Ser Leu Pro Ser

185 190 195atc aag cca tcc ggc aag gtg atg aag gct ggt ttc gcc agt gtg gtg 739Ile Lys Pro Ser Gly Lys Val Met Lys Ala Gly Phe Ala Ser Val Val

200 205 210gat ggc ctg aag tat ttg gct ggc caa ccc gtg ttg ttg atg gtg atg 787Asp Gly Leu Lys Tyr Leu Ala Gly Gln Pro Val Leu Leu Met Val Met

215 220 225gtg ctg gat ctt atc gcc atg att ttc ggc atg cca cgt gcg ctt tac 835Val Leu Asp Leu Ile Ala Met Ile Phe Gly Met Pro Arg Ala Leu Tyr230 235 240 245ccc gag atc gca gaa gtg aac ttc ggt ggg ggt gac gcc ggt gca acg 883Pro Glu Ile Ala Glu Val Asn Phe Gly Gly Gly Asp Ala Gly Ala Thr

250 255 260atg ctg gcg ttc atg tac tca tcc atg gct gtt ggc gca gtt ctt ggc 931Met Leu Ala Phe Met Tyr Ser Ser Met Ala Val Gly Ala Val Leu Gly

265 270 275ggc gtg ctg tct ggt tgg gtg gcc cgg att agc cgc cag ggt gtt gca 979Gly Val Leu Ser Gly Trp Val Ala Arg Ile Ser Arg Gln Gly Val Ala

280 285 290gtt tat tgg tgc atc atc gcc tgg ggc gca gcc gtt gct ttg ggt ggt 1027Val Tyr Trp Cys Ile Ile Ala Trp Gly Ala Ala Val Ala Leu Gly Gly

295 300 305gtg gca att gtt gtc agc ccc ggc gcg gtg act gcg tgg gcg tgg atg 1075Val Ala Ile Val Val Ser Pro Gly Ala Val Thr Ala Trp Ala Trp Met310 315 320 325ttc atc atc atg atg gtc att ggt ggc atg gct gac atg ttc agc tcg 1123Phe Ile Ile Met Met Val Ile Gly Gly Met Ala Asp Met Phe Ser Ser

330 335 340gca gtt cga aac gct att ttg cag cag tct gct gcg gaa cat gtg cag 1171Ala Val Arg Asn Ala Ile Leu Gln Gln Ser Ala Ala Glu His Val Gln

345 350 355ggc cga atc caa ggt gtg tgg atc atc gtc gtg gtg ggt gga cct cgt 1219Gly Arg Ile Gln Gly Val Trp Ile Ile Val Val Val Gly Gly Pro Arg

360 365 370tta gct gac gtc ctt cac ggt tgg gcc gct gag ccc ctc ggc gca ggt 1267Leu Ala Asp Val Leu His Gly Trp Ala Ala Glu Pro Leu Gly Ala Gly

375 380 385tgg acg gta tta tgg ggc gga gta gcg gtg gtt gta ctc act gca att 1315Trp Thr Val Leu Trp Gly Gly Val Ala Val Val Val Leu Thr Ala Ile390 395 400 405tgt atg gtg gcg gtg cct aaa ttc tgg aaa tac gag aaa cca aaa att 1363Cys Met Val Ala Val Pro Lys Phe Trp Lys Tyr Glu Lys Pro Lys Ile

410415420 accggc atc taaatactta tccatgccca ttt 1395Thr Gly Ile<210>600<211>424<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>600Val Ser Phe Arg Asp Ile Phe Ala Asp Thr Arg Pro Leu Lys Glu Pro 151015 Ala Phe Lys Arg Leu Trp Leu Gly Asn Val Ala Thr Val Ile Gly Ala

20 25 30Gln Leu Thr Val Val Ala Val Pro Val Gln Ile Tyr Gln Met Thr Gly

35 40 45Ser Ser Gly Tyr Val Gly Leu Thr Gly Leu Phe Gly Leu Ile Pro Leu

50 55 60Val Ile Phe Gly Leu Tyr Gly Gly Ser Ile Ala Asp Ala Phe Asp Lys 65 70 75 80Arg Ile Val Leu Ile Cys Thr Thr Ile Gly Met Cys Val Thr Thr Ala

85 90 95Gly Phe Trp Val Leu Thr Ile Leu Gly Asn Glu Asn Ile Trp Leu Leu

100 105 110Leu Ile Asn Phe Ser Leu Gln Gln Ala Phe Phe Ala Val Asn Gln Pro

115 120 125Thr Arg Thr Ala Ile Leu Arg Ser Ile Leu Pro Ile Asp Gln Leu Ala

130 135 140Ser Ala Thr Ser Leu Asn Met Leu Leu Met Gln Thr Gly Ala Ile Val145 150 155 160Gly Pro Leu Ile Ala Gly Ala Leu Ile Pro Leu Ile Gly Phe Gly Trp

165 170 175Leu Tyr Phe Leu Asp Val Val Ser Ile Ile Pro Thr Leu Trp Ala Val

180 185 190Trp Ser Leu Pro Ser Ile Lys Pro Ser Gly Lys Val Met Lys Ala Gly

195 200 205Phe Ala Ser Val Val Asp Gly Leu Lys Tyr Leu Ala Gly Gln Pro Val

210 215 220Leu Leu Met Val Met Val Leu Asp Leu Ile Ala Met Ile Phe Gly Met225 230 235 240Pro Arg Ala Leu Tyr Pro Glu Ile Ala Glu Val Asn Phe Gly Gly Gly

245 250 255Asp Ala Gly Ala Thr Met Leu Ala Phe Met Tyr Ser Ser Met Ala Val

260 265 270Gly Ala Val Leu Gly Gly Val Leu Ser Gly Trp Val Ala Arg Ile Ser

275 280 285Arg Gln Gly Val Ala Val Tyr Trp Cys Ile Ile Ala Trp Gly Ala Ala

290 295 300Val Ala Leu Gly Gly Val Ala Ile Val Val Ser Pro Gly Ala Val Thr305 310 315 320Ala Trp Ala Trp Met Phe Ile Ile Met Met Val Ile Gly Gly Met Ala

325 330 335Asp Met Phe Ser Ser Ala Val Arg Asn Ala Ile Leu Gln Gln Ser Ala

340 345 350Ala Glu His Val Gln Gly Arg Ile Gln Gly Val Trp Ile Ile Val Val

355 360 365Val Gly Gly Pro Arg Leu Ala Asp Val Leu His Gly Trp Ala Ala Glu

370 375 380Pro Leu Gly Ala Gly Trp Thr Val Leu Trp Gly Gly Val Ala Val Val385 390 395 400Val Leu Thr Ala Ile Cys Met Val Ala Val Pro Lys Phe Trp Lys Tyr

405 410 415Glu Lys Pro Lys Ile Thr Gly Ile

420<210>601<211>1461<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1438)<223>RXN01995<400>601ccgacgcaaa ggcatgcgcc tgcgtgtctc gagtagtctc ctccccttcc tcgtccccaa 60cctcgaccat tacggtcgcc ctctcctaaa ggagcctggc atg gat atc cgc caa 115

Met Asp Ile Arg Gln

1 5aca att aac gac aca gca atg tcg aga tat cag tgg ttc att gta ttt 163Thr Ile Asn Asp Thr Ala Met Ser Arg Tyr Gln Trp Phe Ile Val Phe

10 15 20atc gca gtg ctg ctc aac gca ctg gac ggc ttt gat gtc ctc gcc atg 211Ile Ala Val Leu Leu Asn Ala Leu Asp Gly Phe Asp Val Leu Ala Met

25 30 35tct ttt act gcg aat gca gtg acc gaa gaa ttt gga ctg agt ggc agc 259Ser Phe Thr Ala Asn Ala Val Thr Glu Glu Phe Gly Leu Ser Gly Ser

40 45 50cag ctt ggt gtg ctg ctg agt tcc gcg ctg ttc ggc atg acc gct gga 307Gln Leu Gly Val Leu Leu Ser Ser Ala Leu Phe Gly Met Thr Ala Gly

55 60 65tct ttg ctg ttc ggt ccg atc ggt gac cgt ttc ggc cgt aag aat gcc 355Ser Leu Leu Phe Gly Pro Ile Gly Asp Arg Phe Gly Arg Lys Asn Ala 70 75 80 85ctg atg atc gcg ctg ctg ttc aac gtg gtg gga ttg gta ttg tcc gcc 403Leu Met Ile Ala Leu Leu Phe Asn Val Val Gly Leu Val Leu Ser Ala

90 95 100acc gcg cag tcc gca ggc cag ttg ggc gtg tgg cgt ttg atc act ggt 451Thr Ala Gln Ser Ala Gly Gln Leu Gly Val Trp Arg Leu Ile Thr Gly

105 110 115atc ggc atc ggc gga atc ctc gcc tgc atc aca gtg gtg atc agt gag 499Ile Gly Ile Gly Gly Ile Leu Ala Cys Ile Thr Val Val Ile Ser Glu

120 125 130ttc tcc aac aac aaa aac cgc ggc atg gcc atg tcc atc tac gct gct 547Phe Ser Asn Asn Lys Asn Arg Gly Met Ala Met Ser Ile Tyr Ala Ala

135 140 145ggt tac ggc atc ggc gcg tcc ttg ggc ggt ttc ggc gca gcg cag ctc 595Gly Tyr Gly Ile Gly Ala Ser Leu Gly Gly Phe Gly Ala Ala Gln Leu150 155 160 165atc cca aca ttt gga tgg cgc tcc gtg ttc gca gcc ggt gcg atc gca 643Ile Pro Thr Phe Gly Trp Arg Ser Val Phe Ala Ala Gly Ala Ile Ala

170 175 180act ggt atc gcc acc atc gct act ttc ttc ttc ctg cca gaa tcc gtt 691Thr Gly Ile Ala Thr Ile Ala Thr Phe Phe Phe Leu Pro Glu Ser Val

185 190 195gat tgg ctg agc act cgc cgc cct gcg ggc gct cgc gac aag atc aat 739Asp Trp Leu Ser Thr Arg Arg Pro Ala Gly Ala Arg Asp Lys Ile Asn

200 205 210tac att gcg cgc cgc ctg ggc aaa gtc ggt acc ttt gag ctt cca ggc 787Tyr Ile Ala Arg Arg Leu Gly Lys Val Gly Thr Phe Glu Leu Pro Gly

215 220 225gaa caa agc ttg tcg acg aaa aaa gcc ggt ctc caa tcg tat gca gtg 835Glu Gln Ser Leu Ser Thr Lys Lys Ala Gly Leu Gln Ser Tyr Ala Val230 235 240 245ctc gtt aac aaa gag aac cgt gga acc agc atc aag ctg tgg gtt gcg 883Leu Val Asn Lys Glu Asn Arg Gly Thr Ser Ile Lys Leu Trp Val Ala

250 255 260ttc ggc atc gtg atg ttc ggc ttc tac ttc gcc aac act tgg acc ccg 931Phe Gly Ile Val Met Phe Gly Phe Tyr Phe Ala Asn Thr Trp Thr Pro

265 270 275aag ctg ctc gtg gaa acc gga atg tca gaa cag cag ggc atc atc ggt 979Lys Leu Leu Val Glu Thr Gly Met Ser Glu Gln Gln Gly Ile Ile Gly

280 285 290ggt ttg atg ttg tcc atg ggt gga gca ttc ggc tcc ctg ctc tac ggt 1027Gly Leu Met Leu Ser Met Gly Gly Ala Phe Gly Ser Leu Leu Tyr Gly

295 300 305ttc ctc acc acc aag ttc agc tcc cga aac aca ctg atg acc ttc atg 1075Phe Leu Thr Thr Lys Phe Ser Ser Arg Asn Thr Leu Met Thr Phe Met310 315 320 325gtg ctg tcc ggc ctg acg ctg atc ctg ttc att tcc tcc acc tct gtt 1123Val Leu Ser Gly Leu Thr Leu Ile Leu Phe Ile Ser Ser Thr Ser Val

330 335 340cca tcc atc gcg ttt gcc agc ggc gtt gtc gtg ggc atg ctg atc aat 1171Pro Ser Ile Ala Phe Ala Ser Gly Val Val Val Gly Met Leu Ile Asn

345 350 355ggt tgt gtg gct ggt ctg tac acc ctg tcc cca cag ctg tac tcc gct 1219Gly Cys Val Ala Gly Leu Tyr Thr Leu Ser Pro Gln Leu Tyr Ser Ala

360 365 370gaa gta cgc acc act ggt gtg ggc gct gcg att ggt atg ggt cgt gtc 1267Glu Val Arg Thr Thr Gly Val Gly Ala Ala Ile Gly Met Gly Arg Val

375 380 385ggt gcg att tcc gcg cca ctg ctg gtg ggt ggc ctg ctg gat tct ggc 1315Gly Ala Ile Ser Ala Pro Leu Leu Val Gly Gly Leu Leu Asp Ser Gly390 395 400 405tgg tcc cca acg cag ctg tat gtt ggt gtg gca gtg att gtt att gcc 1363Trp Ser Pro Thr Gln Leu Tyr Val Gly Val Ala Val Ile Val Ile Ala

410 415 420ggt gca acc gca ttg att ggg atg cgc act cag gcg gta gcc gtc gaa 1411Gly Ala Thr Ala Leu Ile Gly Met Arg Thr Gln Ala Val Ala Val Glu

425 430 435aag cag cct gaa gcc cta gcg acc aaa tagggccgcg attcctagca 1458Lys Gln Pro Glu Ala Leu Ala Thr Lys

440445 tgc1461<210>602<211>446<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>602Met Asp Ile Arg Gln Thr Ile Asn Asp Thr Ala Met Ser Arg Tyr Gln 151015 Trp Phe Ile Val Phe Ile Ala Val Leu Leu Asn Ala Leu Asp Gly Phe

20 25 30Asp Val Leu Ala Met Ser Phe Thr Ala Asn Ala Val Thr Glu Glu Phe

35 40 45Gly Leu Ser Gly Ser Gln Leu Gly Val Leu Leu Ser Ser Ala Leu Phe

50 55 60Gly Met Thr Ala Gly Ser Leu Leu Phe Gly Pro Ile Gly Asp Arg Phe 65 70 75 80Gly Arg Lys Asn Ala Leu Met Ile Ala Leu Leu Phe Asn Val Val Gly

85 90 95Leu Val Leu Ser Ala Thr Ala Gln Ser Ala Gly Gln Leu Gly Val Trp

100 105 110Arg Leu Ile Thr Gly Ile Gly Ile Gly Gly Ile Leu Ala Cys Ile Thr

115 120 125Val Val Ile Ser Glu Phe Ser Asn Asn Lys Asn Arg Gly Met Ala Met

130 135 140Ser Ile Tyr Ala Ala Gly Tyr Gly Ile Gly Ala Ser Leu Gly Gly Phe145 150 155 160Gly Ala Ala Gln Leu Ile Pro Thr Phe Gly Trp Arg Ser Val Phe Ala

165 170 175Ala Gly Ala Ile Ala Thr Gly Ile Ala Thr Ile Ala Thr PhePhe Phe

180 185 190Leu Pro Glu Ser Val Asp Trp Leu Ser Thr Arg Arg Pro Ala Gly Ala

195 200 205Arg Asp Lys Ile Asn Tyr Ile Ala Arg Arg Leu Gly Lys Val Gly Thr

210 215 220Phe Glu Leu Pro Gly Glu Gln Ser Leu Ser Thr Lys Lys Ala Gly Leu225 230 235 240Gln Ser Tyr Ala Val Leu Val Asn Lys Glu Asn Arg Gly Thr Ser Ile

245 250 255Lys Leu Trp Val Ala Phe Gly Ile Val Met Phe Gly Phe Tyr Phe Ala

260 265 270Asn Thr Trp Thr Pro Lys Leu Leu Val Glu Thr Gly Met Ser Glu Gln

275 280 285Gln Gly Ile Ile Gly Gly Leu Met Leu Ser Met Gly Gly Ala Phe Gly

290 295 300Ser Leu Leu Tyr Gly Phe Leu Thr Thr Lys Phe Ser Ser Arg Asn Thr305 310 315 320Leu Met Thr Phe Met Val Leu Ser Gly Leu Thr Leu Ile Leu Phe Ile

325 330 335Ser Ser Thr Ser Val Pro Ser Ile Ala Phe Ala Ser Gly Val Val Val

340 345 350Gly Met Leu Ile Asn Gly Cys Val Ala Gly Leu Tyr Thr Leu Ser Pro

355 360 365Gln Leu Tyr Ser Ala Glu Val Arg Thr Thr Gly Val Gly Ala Ala Ile

370 375 380Gly Met Gly Arg Val Gly Ala Ile Ser Ala Pro Leu Leu Val Gly Gly385 390 395 400Leu Leu Asp Ser Gly Trp Ser Pro Thr Gln Leu Tyr Val GlyVal Ala

405 410 415Val Ile Val Ile Ala Gly Ala Thr Ala Leu Ile Gly Met Arg Thr Gln

420 425 430Ala Val Ala Val Glu Lys Gln Pro Glu Ala Leu Ala Thr Lys

435440445<210>603<211>813<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (790)<223>RXN00661<400>603cggatgcaag agaaccgtgg tttcgctgat ttttggcgaa cccggaatta aggccccgag 60gattacatgc ttttaaatcc tttgaaaagg ggacaagatc atg aat cct ata acc 115

Met Asn Pro Ile Thr

1 5gaa tta tta gac gca aca cta tgg atc ggc gga gtt ccg att ctg tgg 163Glu Leu Leu Asp Ala Thr Leu Trp Ile Gly Gly Val Pro Ile Leu Trp

10 15 20cgc gaa atc atc ggc aac gtt ttc gga tta ttt agc gcg tgg gca gga 211Arg Glu Ile Ile Gly Asn Val Phe Gly Leu Phe Ser Ala Trp Ala Gly

25 30 35atg cga cgc atc gtg tgg gca tgg ccc atc ggc atc ata ggc aac gcg 259Met Arg Arg Ile Val Trp Ala Trp Pro Ile Gly Ile Ile Gly Asn Ala

40 45 50ctg ctg ttc aca gta ttt atg ggc ggc ctt ttc cac act cca caa aac 307Leu Leu Phe Thr Val Phe Met Gly Gly Leu Phe His Thr Pro Gln Asn

55 60 65ctc gat ctc tac ggc caa gcg ggt cgc cag atc atg ttc atc atc gtc 355Leu Asp Leu Tyr Gly Gln Ala Gly Arg Gln Ile Met Phe Ile Ile Val 70 75 80 85agt ggt tat ggc tgg tac caa tgg tcg gcc gca aaa cgt cgc gcactc 403Ser Gly Tyr Gly Trp Tyr Gln Trp Ser Ala Ala Lys Arg Arg Ala Leu

90 95 100acc cca gaa aat gca gta gca gtg gtt cct cgc tgg gca agc acc aaa 451Thr Pro Glu Asn Ala Val Ala Val Val Pro Arg Trp Ala Ser Thr Lys

105 110 115gaa cgc gcc ggc att gtg att gcg gcg gtt gtg gga aca ctc agc ttt 499Glu Arg Ala Gly Ile Val Ile Ala Ala Val Val Gly Thr Leu Ser Phe

120 125 130gcc tgg att ttc caa gca ctc ggc tcc tgg ggg cca tgg gcc gac gcg 547Ala Trp Ile Phe Gln Ala Leu Gly Ser Trp Gly Pro Trp Ala Asp Ala

135 140 145tgg att ttc gtc ggc tca atc ctg gct acc tac gga atg gct cgc gga 595Trp Ile Phe Val Gly Ser Ile Leu Ala Thr Tyr Gly Met Ala Arg Gly150 155 160 165tgg aca gag ttc tgg ctg atc tgg atc gcc gtc gac ata gtt ggc gtt 643Trp Thr Glu Phe Trp Leu Ile Trp Ile Ala Val Asp Ile Val Gly Val

170 175 180cct cta ctt ttg act gct ggc tac tac cca tcc gcg gtg ctt tac ctg 691Pro Leu Leu Leu Thr Ala Gly Tyr Tyr Pro Ser Ala Val Leu Tyr Leu

185 190 195gtg tac ggt gcg ttt gtc agc tgg gga ttt gtc gtg tgg ctg cgg gtg 739Val Tyr Gly Ala Phe Val Ser Trp Gly Phe Val Val Trp Leu Arg Val

200 205 210caa aaa gca gac aag gct cgt gcg ctg gaa gct cag gag tct gtg aca 787Gln Lys Ala Asp Lys Ala Arg Ala Leu Glu Ala Gln Glu Ser Val Thr

215220225 gtc tgaaaagcgt ttactaaata gaa 813Val230<210>604<211>230<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>604MetAsn Pro Ile Thr Glu Leu Leu Asp Ala Thr Leu Trp Ile Gly Gly 151015 Val Pro Ile Leu Trp Arg Glu Ile Ile Gly Asn Val Phe Gly Leu Phe

20 25 30Ser Ala Trp Ala Gly Met Arg Arg Ile Val Trp Ala Trp Pro Ile Gly

35 40 45Ile Ile Gly Asn Ala Leu Leu Phe Thr Val Phe Met Gly Gly Leu Phe

50 55 60His Thr Pro Gln Asn Leu Asp Leu Tyr Gly Gln Ala Gly Arg Gln Ile 65 70 75 80Met Phe Ile Ile Val Ser Gly Tyr Gly Trp Tyr Gln Trp Ser Ala Ala

85 90 95Lys Arg Arg Ala Leu Thr Pro Glu Asn Ala Val Ala Val Val Pro Arg

100 105 110Trp Ala Ser Thr Lys Glu Arg Ala Gly Ile Val Ile Ala Ala Val Val

115 120 125Gly Thr Leu Ser Phe Ala Trp Ile Phe Gln Ala Leu Gly Ser Trp Gly

130 135 140Pro Trp Ala Asp Ala Trp Ile Phe Val Gly Ser Ile Leu Ala Thr Tyr145 150 155 160Gly Met Ala Arg Gly Trp Thr Glu Phe Trp Leu Ile Trp Ile Ala Val

165 170 175Asp Ile Val Gly Val Pro Leu Leu Leu Thr Ala Gly Tyr Tyr Pro Ser

180 185 190Ala Val Leu Tyr Leu Val Tyr Gly Ala Phe Val Ser Trp Gly Phe Val

195 200 205Val Trp Leu Arg Val Gln Lys Ala Asp Lys Ala Arg Ala Leu Glu Ala

210215220 Gln Glu Ser Val Thr Val 225230<210>605<211>1332<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101).)

Met His Ala Ser Ser

1 5ccc caa cct cac cct cag cgc acc cgt gtt ctc agc ggc ctg att ttc 163Pro Gln Pro His Pro Gln Arg Thr Arg Val Leu Ser Gly Leu Ile Phe

10 15 20gcc caa atc atg gtt ggt gca tcc aat ggc gtg acg cta tcg atg gga 211Ala Gln Ile Met Val Gly Ala Ser Asn Gly Val Thr Leu Ser Met Gly

25 30 35agt ttg ctg gca gca cac ttg gcg gga gct tcg tgg gga gga tca gcc 259Ser Leu Leu Ala Ala His Leu Ala Gly Ala Ser Trp Gly Gly Ser Ala

40 45 50gcc aca ttg acc acg atc ggc gca gct atc ttt tcg att ccc ctt gcc 307Ala Thr Leu Thr Thr Ile Gly Ala Ala Ile Phe Ser Ile Pro Leu Ala

55 60 65cgc atg gtc tcc aca tac gat cgc cga act tca ctc agc acg ggc atg 355Arg Met Val Ser Thr Tyr Asp Arg Arg Thr Ser Leu Ser Thr Gly Met 70 75 80 85ttg ctt ggt tgc gtg ggc gca cta ctg gcg atc ctc ggc gca caa ttc 403Leu Leu Gly Cys Val Gly Ala Leu Leu Ala Ile Leu Gly Ala Gln Phe

90 95 100ggc ttg ttt cca gta gta ctt ttg gca ttt ttg ttc ctc gga tcc atg 451Gly Leu Phe Pro Val Val Leu Leu Ala Phe Leu Phe Leu Gly Ser Met

105 110 115tcg gcg gtt aac ctc caa gca cgt ttc gcc gca acc gac gtg gcc agt 499Ser Ala Val Asn Leu Gln Ala Arg Phe Ala Ala Thr Asp Val Ala Ser

120 125 130gaa gaa acc cgc ggccgc gac ctc tcg atc gtt gtg tgg tcc acc acc 547Glu Glu Thr Arg Gly Arg Asp Leu Ser Ile Val Val Trp Ser Thr Thr

135 140 145atc ggc gca atc gcc gga cca aat tta ttt gaa cca agc gcc cga ttc 595Ile Gly Ala Ile Ala Gly Pro Asn Leu Phe Glu Pro Ser Ala Arg Phe150 155 160 165agc gaa acc ctg ggc ctc gaa caa cat gcc ggc gca tac ctg ctg tgt 643Ser Glu Thr Leu Gly Leu Glu Gln His Ala Gly Ala Tyr Leu Leu Cys

170 175 180tta ttt ggc cag ctc atc gcc atc gca gtc tgg cga ttc acc ctc ccc 691Leu Phe Gly Gln Leu Ile Ala Ile Ala Val Trp Arg Phe Thr Leu Pro

185 190 195aaa ggc ctc aaa ccc gaa gcc acc cca aat gca cca aca gaa aag aag 739Lys Gly Leu Lys Pro Glu Ala Thr Pro Asn Ala Pro Thr Glu Lys Lys

200 205 210cgc ctc acc ccg aaa gcc ctc caa gcc atc aca tcg gtt gca acc gca 787Arg Leu Thr Pro Lys Ala Leu Gln Ala Ile Thr Ser Val Ala Thr Ala

215 220 225cac ttc tcc atg gtc ggt ctc atg tcc atg gcc gcc atc cac atg caa 835His Phe Ser Met Val Gly Leu Met Ser Met Ala Ala Ile His Met Gln230 235 240 245ggc cac ggc gcc agc ctc acc atc atc ggc ttc acc atc agt ttg cac 883Gly His Gly Ala Ser Leu Thr Ile Ile Gly Phe Thr Ile Ser Leu His

250 255 260gtc gcc gga atg tac gca ctc tca cca gtg ttc ggc ctg ctc aca gac 931Val Ala Gly Met Tyr Ala Leu Ser Pro Val Phe Gly Leu Leu Thr Asp

265 270 275aaa ctc ggc cgc aat gtc acc atc tat tcc ggc ttc gcc atg ctc gcc 979Lys Leu Gly Arg Asn Val Thr Ile Tyr Ser Gly PheAla Met Leu Ala

280 285 290aca tcc gca gca ttt ctt atc att tgg ccc gaa cca cag tgg gcc atg 1027Thr Ser Ala Ala Phe Leu Ile Ile Trp Pro Glu Pro Gln Trp Ala Met

295 300 305atc aca tcc atg atc ctg ctt ggg ctc ggc tgg aac tct gcc ctc gtc 1075Ile Thr Ser Met Ile Leu Leu Gly Leu Gly Trp Asn Ser Ala Leu Val310 315 320 325ggt tct tca aca ttg ctt gtc gac gcc acc ccc atc cac cac cgc acc 1123Gly Ser Ser Thr Leu Leu Val Asp Ala Thr Pro Ile His His Arg Thr

330 335 340tac gcc cag ggg cgc agc gac cta acg atg aat ctt gcg gga gct tca 1171Tyr Ala Gln Gly Arg Ser Asp Leu Thr Met Asn Leu Ala Gly Ala Ser

345 350 355ggc ggg ttg atc gcc gga ccg tta att gcc atg ggc gga atg ccc ttg 1219Gly Gly Leu Ile Ala Gly Pro Leu Ile Ala Met Gly Gly Met Pro Leu

360 365 370ttg gca ggc gtc gtt ctt gca gtt gtg gcg ctt caa acg gtg ctt agt 1267Leu Ala Gly Val Val Leu Ala Val Val Ala Leu Gln Thr Val Leu Ser

375380385 ttc aga acc cgt tca att gaa aag act cct gct tca tgt ttt 1309Phe Arg Thr Arg Ser Ile Glu Lys Thr Pro Ala Ser Cys Phe 390395400 tagcctagga attcacgcac gac 1332<210>606<211>403<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>606Met His Ala Ser Ser Pro Gln Pro His Pro Gln Arg Thr Arg Val Leu 151015 Ser Gly Leu Ile Phe Ala Gln Ile Met Val Gly Ala Ser Asn Gly Val

20 25 30Thr Leu Ser Met Gly Ser Leu Leu Ala Ala His Leu Ala Gly Ala Ser

35 40 45Trp Gly GlySer Ala Ala Thr Leu Thr Thr Ile Gly Ala Ala Ile Phe

50 55 60Ser Ile Pro Leu Ala Arg Met Val Ser Thr Tyr Asp Arg Arg Thr Ser 65 70 75 80Leu Ser Thr Gly Met Leu Leu Gly Cys Val Gly Ala Leu Leu Ala Ile

85 90 95Leu Gly Ala Gln Phe Gly Leu Phe Pro Val Val Leu Leu Ala Phe Leu

100 105 110Phe Leu Gly Ser Met Ser Ala Val Asn Leu Gln Ala Arg Phe Ala Ala

115 120 125Thr Asp Val Ala Ser Glu Glu Thr Arg Gly Arg Asp Leu Ser Ile Val

130 135 140Val Trp Ser Thr Thr Ile Gly Ala Ile Ala Gly Pro Asn Leu Phe Glu145 150 155 160Pro Ser Ala Arg Phe Ser Glu Thr Leu Gly Leu Glu Gln His Ala Gly

165 170 175Ala Tyr Leu Leu Cys Leu Phe Gly Gln Leu Ile Ala Ile Ala Val Trp

180 185 190Arg Phe Thr Leu Pro Lys Gly Leu Lys Pro Glu Ala Thr Pro Asn Ala

195 200 205Pro Thr Glu Lys Lys Arg Leu Thr Pro Lys Ala Leu Gln Ala Ile Thr

210 215 220Ser Val Ala Thr Ala His Phe Ser Met Val Gly Leu Met Ser Met Ala225 230 235 240Ala Ile His Met Gln Gly His Gly Ala Ser Leu Thr Ile Ile Gly Phe

245 250 255Thr Ile Ser Leu His Val Ala Gly Met Tyr Ala Leu Ser Pro Val Phe

260 265270Gly Leu Leu Thr Asp Lys Leu Gly Arg Asn Val Thr Ile Tyr Ser Gly

275 280 285Phe Ala Met Leu Ala Thr Ser Ala Ala Phe Leu Ile Ile Trp Pro Glu

290 295 300Pro Gln Trp Ala Met Ile Thr Ser Met Ile Leu Leu Gly Leu Gly Trp305 310 315 320Asn Ser Ala Leu Val Gly Ser Ser Thr Leu Leu Val Asp Ala Thr Pro

325 330 335Ile His His Arg Thr Tyr Ala Gln Gly Arg Ser Asp Leu Thr Met Asn

340 345 350Leu Ala Gly Ala Ser Gly Gly Leu Ile Ala Gly Pro Leu Ile Ala Met

355 360 365Gly Gly Met Pro Leu Leu Ala Gly Val Val Leu Ala Val Val Ala Leu

370375380 Gln Thr Val Leu Ser Phe Arg Thr Arg Ser Ile Glu Lys Thr Pro Ala 385390395400 Ser Cys Phe<210>607<211>760<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (760)<223>FRXA02561<400>607atctgctcaa taacctaacc taaagtccat gcacgcctcg tcgccccaac ctcaccctca 60gcgcacccgt gttctcagcg gcctgatttt cgcccaaatc atg gtt ggt gca tcc 115

Met Val Gly Ala Ser

1 5aat ggc gtg acg cta tcg atg gga agt ttg ctg gca gca cac ttg gcg 163Asn Gly Val Thr Leu Ser Met Gly Ser Leu Leu Ala Ala His Leu Ala

10 15 20gga gct tcg tgg gga gga tca gcc gcc aca ttg acc acg atc ggc gca 211Gly Ala Ser Trp Gly Gly Ser Ala Ala Thr Leu Thr Thr Ile Gly Ala

25 3035gct atc ttt tcg att ccc ctt gcc cgc atg gtc tcc aca tac gat cgc 259Ala Ile Phe Ser Ile Pro Leu Ala Arg Met Val Ser Thr Tyr Asp Arg

40 45 50cga act tca ctc agc acg ggc atg ttg ctt ggt tgc gtg ggc gca cta 307Arg Thr Ser Leu Ser Thr Gly Met Leu Leu Gly Cys Val Gly Ala Leu

55 60 65ctg gcg atc ctc ggc gca caa ttc ggc ttg ttt cca gta gta ctt ttg 355Leu Ala Ile Leu Gly Ala Gln Phe Gly Leu Phe Pro Val Val Leu Leu 70 75 80 85gca ttt ttg ttc ctc gga tcc atg tcg gcg gtt aac ctc caa gca cgt 403Ala Phe Leu Phe Leu Gly Ser Met Ser Ala Val Asn Leu Gln Ala Arg

90 95 100ttc gcc gca acc gac gtg gcc agt gaa gaa acc cgc ggc cgc gac ctc 451Phe Ala Ala Thr Asp Val Ala Ser Glu Glu Thr Arg Gly Arg Asp Leu

105 110 115tcg atc gtt gtg tgg tcc acc acc atc ggc gca atc gcc gga cca aat 499Ser Ile Val Val Trp Ser Thr Thr Ile Gly Ala Ile Ala Gly Pro Asn

120 125 130tta ttt gaa cca agc gcc cga ttc agc gaa acc ctg ggc ctc gaa caa 547Leu Phe Glu Pro Ser Ala Arg Phe Ser Glu Thr Leu Gly Leu Glu Gln

135 140 145cat gcc ggc gca tac ctg ctg tgt tta ttt ggc cag ctc atc gcc atc 595His Ala Gly Ala Tyr Leu Leu Cys Leu Phe Gly Gln Leu Ile Ala Ile150 155 160 165gca gtc tgg cga ttc acc ctc ccc aaa ggc ctc aaa ccc gaa gcc acc 643Ala Val Trp Arg Phe Thr Leu Pro Lys Gly Leu Lys Pro Glu Ala Thr

170 175 180cca aat gca cca aca gaa aag aag cgc ctc acc ccg aaa gcc ctc caa 691Pro Asn Ala Pro Thr Glu Lys Lys Arg Leu Thr Pro Lys Ala Leu Gln

185 190 195gcc atc aca tcg gtt gca acc gca cac ttc tcc atg gtc ggt ctc atg 739Ala Ile Thr Ser Val Ala Thr Ala His Phe Ser Met Val Gly Leu Met

200 205 210tcc atg gcc gcc atc cac atg 760Ser Met Ala Ala Ile His Met

215220<210>608<211>220<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>608Met Val Gly Ala Ser Asn Gly Val Thr Leu Ser Met Gly Ser Leu Leu 151015 Ala Ala His Leu Ala Gly Ala Ser Trp Gly Gly Ser Ala Ala Thr Leu

20 25 30Thr Thr Ile Gly Ala Ala Ile Phe Ser Ile Pro Leu Ala Arg Met Val

35 40 45Ser Thr Tyr Asp Arg Arg Thr Ser Leu Ser Thr Gly Met Leu Leu Gly

50 55 60Cys Val Gly Ala Leu Leu Ala Ile Leu Gly Ala Gln Phe Gly Leu Phe 65 70 75 80Pro Val Val Leu Leu Ala Phe Leu Phe Leu Gly Ser Met Ser Ala Val

85 90 95Asn Leu Gln Ala Arg Phe Ala Ala Thr Asp Val Ala Ser Glu Glu Thr

100 105 110Arg Gly Arg Asp Leu Ser Ile Val Val Trp Ser Thr Thr Ile Gly Ala

115 120 125Ile Ala Gly Pro Asn Leu Phe Glu Pro Ser Ala Arg Phe Ser Glu Thr

130 135 140Leu Gly Leu Glu Gln His Ala Gly Ala Tyr Leu Leu Cys Leu Phe Gly145 150 155 160Gln Leu Ile Ala Ile Ala Val Trp Arg Phe Thr Leu Pro Lys Gly Leu

165 170 175Lys Pro Glu Ala Thr Pro Asn Ala Pro Thr Glu Lys Lys Arg Leu Thr

180 185 190Pro Lys Ala Leu Gln Ala Ile Thr Ser Val Ala Thr Ala His Phe Ser

195 200 205Met Val Gly Leu Met Ser Met Ala Ala Ile His Met

210215220<210>609<211>461<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (438)<223>FRXA02566<400>609atc agt ttg cac gtc gcc gga atg tac gca ctc tca cca gtg ttc ggc 48 8548 48Ile Ser Leu His Val Ala Gly Met Tyr Ala Leu Ser Pro Val Phe Gly 151015 ctg ctc aca gac aaa ctc ggc cgc aat gtc acc atc tat tcc ggc ttc 96Leu Leu Thr Asp Lys Leu Gly Arg Asn Val Thr Ile Tyr Ser Gly Phe

20 25 30gcc atg ctc gcc aca tcc gca gca ttt ctt atc att tgg ccc gaa cca 144Ala Met Leu Ala Thr Ser Ala Ala Phe Leu Ile Ile Trp Pro Glu Pro

35 40 45cag tgg gcc atg atc aca tcc atg atc ctg ctt ggg ctc ggc tgg aac 192Gln Trp Ala Met Ile Thr Ser Met Ile Leu Leu Gly Leu Gly Trp Asn

50 55 60tct gcc ctc gtc ggt tct tca aca ttg ctt gtc gac gcc acc ccc atc 240Ser Ala Leu Val Gly Ser Ser Thr Leu Leu Val Asp Ala Thr Pro Ile 65 70 75 80cac cac cgc acc tac gcc cag ggg cgc agc gac cta acg atg aat ctt 288His His Arg Thr Tyr Ala Gln Gly Arg Ser Asp Leu Thr Met Asn Leu

85 90 95gcg gga gct tca ggc ggg ttg atc gcc gga ccg tta att gcc atg ggc 336Ala Gly Ala Ser Gly Gly Leu Ile AlaGly Pro Leu Ile Ala Met Gly

100 105 110gga atg ccc ttg ttg gca ggc gtc gtt ctt gca gtt gtg gcg ctt caa 384Gly Met Pro Leu Leu Ala Gly Val Val Leu Ala Val Val Ala Leu Gln

115 120 125acg gtg ctt agt ttc aga acc cgt tca att gaa aag act cct gct tca 432Thr Val Leu Ser Phe Arg Thr Arg Ser Ile Glu Lys Thr Pro Ala Ser

130135140 tgt ttt tagcctagga attcacgcac gac 461Cys Phe145<210>610<211>146<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>610Ile Ser Leu His Val Ala Gly Met Tyr Ala Leu Ser Pro Val Phe Gly 151015 Leu Leu Thr Asp Lys Leu Gly Arg Asn Val Thr Ile Tyr Ser Gly Phe

20 25 30Ala Met Leu Ala Thr Ser Ala Ala Phe Leu Ile Ile Trp Pro Glu Pro

35 40 45Gln Trp Ala Met Ile Thr Ser Met Ile Leu Leu Gly Leu Gly Trp Asn

50 55 60Ser Ala Leu Val Gly Ser Ser Thr Leu Leu Val Asp Ala Thr Pro Ile 65 70 75 80His His Arg Thr Tyr Ala Gln Gly Arg Ser Asp Leu Thr Met Asn Leu

85 90 95Ala Gly Ala Ser Gly Gly Leu Ile Ala Gly Pro Leu Ile Ala Met Gly

100 105 110Gly Met Pro Leu Leu Ala Gly Val Val Leu Ala Val Val Ala Leu Gln

115 120 125Thr Val Leu Ser Phe Arg Thr Arg Ser Ile Glu Lys Thr Pro Ala Ser

130135140 Cys Phe145<210>611<211>1527<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220>CDS<222>(101) }, (1504)<223>RXA00051<400>611cagtaaaagt gcaccgacac taagaatcct tatccttcag agtaaggtga tctgcgtcaa 60aaaatgtccg ctattcaccc gaaacgaggt cagcatctcg atg aat gcc tcc cct 115

Met Asn Ala Ser Pro

1 5gcc cca acc cga tct ttt aaa gga ttg cgg gct cga cac att cac ttc 163Ala Pro Thr Arg Ser Phe Lys Gly Leu Arg Ala Arg His Ile His Phe

10 15 20atc gcg ctg ggt tcc gcg atc ggc acc ggc ttg ttc tac ggt tcc gct 211Ile Ala Leu Gly Ser Ala Ile Gly Thr Gly Leu Phe Tyr Gly Ser Ala

25 30 35ggc gca atc caa gca gct ggt cca tct gta ctc ttg gtc tac ctt ctc 259Gly Ala Ile Gln Ala Ala Gly Pro Ser Val Leu Leu Val Tyr Leu Leu

40 45 50ggt ggc gcc gtc gtg tac ttc atg ctg cgc gca ctc ggc gag atg gct 307Gly Gly Ala Val Val Tyr Phe Met Leu Arg Ala Leu Gly Glu Met Ala

55 60 65gtg cat cac cca gtc cgt ggt tcc ttc gcg gtc tac acc cgc gca cac 355Val His His Pro Val Arg Gly Ser Phe Ala Val Tyr Thr Arg Ala His 70 75 80 85ctt ggc gga tgg gca ggc tac atc acc ggc tgg atg ttc gcg ttt gag 403Leu Gly Gly Trp Ala Gly Tyr Ile Thr Gly Trp Met Phe Ala Phe Glu

90 95 100atg ctc atc gtc tgc ctg gct gac ctc aca gcc atc ggc atc tat atg 451Met Leu Ile Val Cys Leu Ala Asp Leu Thr Ala Ile Gly Ile Tyr Met

105 110 115aac ttc tgg ttc ccc ggc acc cca caa tgg act tgg gtg gta gcc acc 499Asn Phe Trp Phe Pro Gly Thr Pro Gln Trp Thr Trp Val Val Ala Thr

120 125 130ctt ctt att gtc ggt ggc gca aac ctc gca tca gtg cgt tgg ttc ggt 547Leu Leu Ile Val Gly Gly Ala Asn Leu Ala Ser Val Arg Trp Phe Gly

135 140 145gag ctc gag ttc atc ttc acc atc att aag gtc acc gca gtt gtc gcc 595Glu Leu Glu Phe Ile Phe Thr Ile Ile Lys Val Thr Ala Val Val Ala150 155 160 165atg atc gtc ggc ggc gca gcc atc ctc gca ttc ggt ctc ggc gcc aac 643Met Ile Val Gly Gly Ala Ala Ile Leu Ala Phe Gly Leu Gly Ala Asn

170 175 180gct gaa gtt gcc ggc gta tcc aac ctc tgg gag cac ggc gga ttc ttc 691Ala Glu Val Ala Gly Val Ser Asn Leu Trp Glu His Gly Gly Phe Phe

185 190 195ccc aac ggt gtt gaa ggc atg atc gca gcc ttc atc ctt gtt ctc ttc 739Pro Asn Gly Val Glu Gly Met Ile Ala Ala Phe Ile Leu Val Leu Phe

200 205 210gca ttc ggt ggc acc gaa atc atc ggt gtt gca ggc tct gaa gct gaa 787Ala Phe Gly Gly Thr Glu Ile Ile Gly Val Ala Gly Ser Glu Ala Glu

215 220 225gat cct gag aag tcc atc ccc aag gct gtt aat act gtc cca gta cgc 835Asp Pro Glu Lys Ser Ile Pro Lys Ala Val Asn Thr Val Pro Val Arg230 235 240 245atc ctc ctc ttc tat gtg ggt gcc atc ctg gtg atc ctt gcc ctt aat 883Ile Leu Leu Phe Tyr Val Gly Ala Ile Leu Val Ile Leu Ala Leu Asn

250 255 260cct tgg cct tcc atc acc ggc gaa gaa tcc cca ttc gtc cag atc ttc 931Pro Trp Pro Ser Ile Thr Gly Glu Glu Ser Pro Phe Val Gln Ile Phe

265 270 275gac accctc ggc gtc aac tgg gct gct ggt ctc ctc aac gcc gtg gtc 979Asp Thr Leu Gly Val Asn Trp Ala Ala Gly Leu Leu Asn Ala Val Val

280 285 290atc acc gct gca ctg tct gcc atc aac gct gac ctc ttc ggc gct ggc 1027Ile Thr Ala Ala Leu Ser Ala Ile Asn Ala Asp Leu Phe Gly Ala Gly

295 300 305cgc gtt ctc act ggt ctt gcg aag gaa aac ctc gca cca aag gcc atg 1075Arg Val Leu Thr Gly Leu Ala Lys Glu Asn Leu Ala Pro Lys Ala Met310 315 320 325ggc aag atc gcc aag aac ggc gtt cca gtc atg acc acc acc atc atg 1123Gly Lys Ile Ala Lys Asn Gly Val Pro Val Met Thr Thr Thr Ile Met

330 335 340atc atc gtc ttg atc gtg gga gta atc ctc aac gca gtg ctt ccc gag 1171Ile Ile Val Leu Ile Val Gly Val Ile Leu Asn Ala Val Leu Pro Glu

345 350 355cgc gtc ttc gag atc gtc gct tcc cta gca acc ttc gcc aca gtt tac 1219Arg Val Phe Glu Ile Val Ala Ser Leu Ala Thr Phe Ala Thr Val Tyr

360 365 370gtc tgg ctg atg ate ctg ctc gca cag gtg gga tcc cgc cga aac atg 1267Val Trp Leu Met Ile Leu Leu Ala Gln Val Gly Ser Arg Arg Asn Met

375 380 385cct gcc gac gag gtc aag tcc ctg aag ttc cct gtc ccc ttc tac ccc 1315Pro Ala Asp Glu Val Lys Ser Leu Lys Phe Pro Val Pro Phe Tyr Pro390 395 400 405ttc gga caa tac ttc gcg atc cta ttt atc gcc ttc acc ttc ggc atc 1363Phe Gly Gln Tyr Phe Ala Ile Leu Phe Ile Ala Phe Thr Phe Gly Ile

410 415 420atg gtc tgg tac gac aac tac cac ctg cca ctc gcc gtc ggc gtt gga 1411Met Val Trp Tyr Asp Asn Tyr HisLeu Pro Leu Ala Val Gly Val Gly

425 430 435ttc ctt gtc ctg atg aca atc ctt tac tac gcc aca ggc cga cca aag 1459Phe Leu Val Leu Met Thr Ile Leu Tyr Tyr Ala Thr Gly Arg Pro Lys

440 445 450gcg atc gct ccg atc gat tat gaa gag cta gat ccg cga cgc gat 1504Ala Ile Ala Pro Ile Asp Tyr Glu Glu Leu Asp Pro Arg Arg Asp

455460465 taatctagac tcgcacgaaa aag 1527<210>612<211>468<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>612Met Asn Ala Ser Pro Ala Pro Thr Arg Ser Phe Lys Gly Leu Arg Ala 151015 Arg His Ile His Phe Ile Ala Leu Gly Ser Ala Ile Gly Thr Gly Leu

20 25 30Phe Tyr Gly Ser Ala Gly Ala Ile Gln Ala Ala Gly Pro Ser Val Leu

35 40 45Leu Val Tyr Leu Leu Gly Gly Ala Val Val Tyr Phe Met Leu Arg Ala

50 55 60Leu Gly Glu Met Ala Val His His Pro Val Arg Gly Ser Phe Ala Val 65 70 75 80Tyr Thr Arg Ala His Leu Gly Gly Trp Ala Gly Tyr Ile Thr Gly Trp

85 90 95Met Phe Ala Phe Glu Met Leu Ile Val Cys Leu Ala Asp Leu Thr Ala

100 105 110Ile Gly Ile Tyr Met Asn Phe Trp Phe Pro Gly Thr Pro Gln Trp Thr

115 120 125Trp Val Val Ala Thr Leu Leu Ile Val Gly Gly Ala Asn Leu Ala Ser

130 135 140Val Arg Trp Phe Gly Glu Leu Glu Phe Ile Phe Thr Ile Ile Lys Val145 150 155160Thr Ala Val Val Ala Met Ile Val Gly Gly Ala Ala Ile Leu Ala Phe

165 170 175Gly Leu Gly Ala Asn Ala Glu Val Ala Gly Val Ser Asn Leu Trp Glu

180 185 190His Gly Gly Phe Phe Pro Asn Gly Val Glu Gly Met Ile Ala Ala Phe

195 200 205Ile Leu Val Leu Phe Ala Phe Gly Gly Thr Glu Ile Ile Gly Val Ala

210 215 220Gly Ser Glu Ala Glu Asp Pro Glu Lys Ser Ile Pro Lys Ala Val Asn225 230 235 240Thr Val Pro Val Arg Ile Leu Leu Phe Tyr Val Gly Ala Ile Leu Val

245 250 255Ile Leu Ala Leu Asn Pro Trp Pro Ser Ile Thr Gly Glu Glu Ser Pro

260 265 270Phe Val Gln Ile Phe Asp Thr Leu Gly Val Asn Trp Ala Ala Gly Leu

275 280 285Leu Asn Ala Val Val Ile Thr Ala Ala Leu Ser Ala Ile Asn Ala Asp

290 295 300Leu Phe Gly Ala Gly Arg Val Leu Thr Gly Leu Ala Lys Glu Asn Leu305 310 315 320Ala Pro Lys Ala Met Gly Lys Ile Ala Lys Asn Gly Val Pro Val Met

325 330 335Thr Thr Thr Ile Met Ile Ile Val Leu Ile Val Gly Val Ile Leu Asn

340 345 350Ala Val Leu Pro Glu Arg Val Phe Glu Ile Val Ala Ser Leu Ala Thr

355 360 365Phe Ala Thr Val Tyr Val Trp Leu Met Ile Leu Leu Ala Gln Val Gly

370 375 380Ser Arg Arg Asn Met Pro Ala Asp Glu Val Lys Ser Leu Lys Phe Pro385 390 395 400Val Pro Phe Tyr Pro Phe Gly Gln Tyr Phe Ala Ile Leu Phe Ile Ala

405 410 415Phe Thr Phe Gly Ile Met Val Trp Tyr Asp Asn Tyr His Leu Pro Leu

420 425 430Ala Val Gly Val Gly Phe Leu Val Leu Met Thr Ile Leu Tyr Tyr Ala

435 440 445Thr Gly Arg Pro Lys Ala Ile Ala Pro Ile Asp Tyr Glu Glu Leu Asp

450455460 Pro Arg Arg Asp465<210>613<211>1578<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1555)<223>RXA01172<400>613taaatttttc tagactaccc agattaagtg agattctttc gtgtcttcga caacttcgac 60aacttcggcc acccgacaag agccgttgag cccgacgggt gtg ctt gcc tcg ttt 115

Val Leu Ala Ser Phe

1 5agg ttc gcg ttt agt agc ccg cgg agg ttt cgc acc gag gtt tta gct 163Arg Phe Ala Phe Ser Ser Pro Arg Arg Phe Arg Thr Glu Val Leu Ala

10 15 20ggc ctc gtg gtg gcg ctc gcg ctg att ccg gag tcg att gcg ttt tcc 211Gly Leu Val Val Ala Leu Ala Leu Ile Pro Glu Ser Ile Ala Phe Ser

25 30 35gta tta gct ggc gtg gat cct aag atg ggt ctt ttt gcg tcg tgc acc 259Val Leu Ala Gly Val Asp Pro Lys Met Gly Leu Phe Ala Ser Cys Thr

40 45 50atg gca atg acc att gcg ctt aca ggt gga cgc cct gcg atg att tcc307Met Ala Met Thr Ile Ala Leu Thr Gly Gly Arg Pro Ala Met Ile Ser

55 60 65gcg gcg aca ggc gct gtg gcg ctg gtg att gca ccg gtg gtt cgg gat 355Ala Ala Thr Gly Ala Val Ala Leu Val Ile Ala Pro Val Val Arg Asp 70 75 80 85cat ggc gtg gaa tat ttc ctg gcc acg gta att ttg gcg ggc att att 403His Gly Val Glu Tyr Phe Leu Ala Thr Val Ile Leu Ala Gly Ile Ile

90 95 100cag att gcg ttg tcg ttg ctg ggt gta gcc aag ctg atg cgg ttc att 451Gln Ile Ala Leu Ser Leu Leu Gly Val Ala Lys Leu Met Arg Phe Ile

105 110 115ccg cgt tcc gtt atg ctc gga ttt gtt aat gcg ctg gcg tgc ttg gtg 499Pro Arg Ser Val Met Leu Gly Phe Val Asn Ala Leu Ala Cys Leu Val

120 125 130ttt ttt gcg cag ctg ccg cac ctg atc gat gtt ccg tgg atg gtg tat 547Phe Phe Ala Gln Leu Pro His Leu Ile Asp Val Pro Trp Met Val Tyr

135 140 145ccg ctg ttc gcg ctg ggt att ggc atc atg ctg ttt tgg ccg aag ctg 595Pro Leu Phe Ala Leu Gly Ile Gly Ile Met Leu Phe Trp Pro Lys Leu150 155 160 165acc tcg gtg att ccg gct ccg ctg att gtt atc gtg gcc ttg act gcg 643Thr Ser Val Ile Pro Ala Pro Leu Ile Val Ile Val Ala Leu Thr Ala

170 175 180atc gtg tgg gtt ttc gga atc aac att cca aac gtc tct gac cag ggc 691Ile Val Trp Val Phe Gly Ile Asn Ile Pro Asn Val Ser Asp Gln Gly

185 190 195gaa ctc ccc tct tcc cta cca gaa ttc ctc att ccc aac gtt ccg ctt 739Glu Leu Pro Ser Ser Leu Pro Glu Phe Leu Ile Pro Asn Val Pro Leu

200205 210act ctt gag act cta aaa att att ggg ccg tat gcg ctt gga atg tcg 787Thr Leu Glu Thr Leu Lys Ile Ile Gly Pro Tyr Ala Leu Gly Met Ser

215 220 225ctt gtt ggg ttg atg gaa tcg ctg ctg acc gcc aag ctg gtc gat gat 835Leu Val Gly Leu Met Glu Ser Leu Leu Thr Ala Lys Leu Val Asp Asp230 235 240 245att acg gag gtt cac tcc aat aaa tcc cgc gaa gct gca ggt cag ggc 883Ile Thr Glu Val His Ser Asn Lys Ser Arg Glu Ala Ala Gly Gln Gly

250 255 260atc gca aac att atc acc gcg ttt ttg ggc ggc atg ggt ggc tgc gcg 931Ile Ala Asn Ile Ile Thr Ala Phe Leu Gly Gly Met Gly Gly Cys Ala

265 270 275atg atc ggc cag acc atg atc aac gtg aaa aac tca gga gcc cgc act 979Met Ile Gly Gln Thr Met Ile Asn Val Lys Asn Ser Gly Ala Arg Thr

280 285 290cgc cta tcc acc ttc ttg gcc ggc ggc ttc ctg ctg ctc ctg gtg gtt 1027Arg Leu Ser Thr Phe Leu Ala Gly Gly Phe Leu Leu Leu Leu Val Val

295 300 305ttg ctg ggc gat gtc gtg ggc aaa atc ccc atg gcg gcg ctc gtg gca 1075Leu Leu Gly Asp Val Val Gly Lys Ile Pro Met Ala Ala Leu Val Ala310 315 320 325gtc atg att atc gtc tcc atc gac acc gcc gac tgg cat tcg ctg aac 1123Val Met Ile Ile Val Ser Ile Asp Thr Ala Asp Trp His Ser Leu Asn

330 335 340ccg cgc acc ctc aaa ttc atg ccg ctg agt gaa acg atc gtc atg ttt 1171Pro Arg Thr Leu Lys Phe Met Pro Leu Ser Glu Thr Ile Val Met Phe

345 350 355ata acg atc atc gcg acc ctc gtc acc gga aac ctg gcg atc ggc gtc 1219Ile Thr Ile Ile Ala Thr Leu Val Thr Gly Asn Leu Ala Ile Gly Val

360 365 370atc ctc gga gtg ctc acc gcc atg gtc atg ttt gct cgc cgc gtg gcc 1267Ile Leu Gly Val Leu Thr Ala Met Val Met Phe Ala Arg Arg Val Ala

375 380 385cac ctc gtg tct gtg gag cgc acc acc gac aac aac atc agc acc tat 1315His Leu Val Ser Val Glu Arg Thr Thr Asp Asn Asn Ile Ser Thr Tyr390 395 400 405acc gtc aag ggc cag cta ttt tgg gcg tcc tcg aac gat atg gtg tac 1363Thr Val Lys Gly Gln Leu Phe Trp Ala Ser Ser Asn Asp Met Val Tyr

410 415 420tcc ttc gac tac tcc gac gag gcc gag cag atc atc atc gat ctc acc 1411Ser Phe Asp Tyr Ser Asp Glu Ala Glu Gln Ile Ile Ile Asp Leu Thr

425 430 435gcc gca gaa atc tgg gac gcc tcc acg gta gcc acg ctg gac agc atc 1459Ala Ala Glu Ile Trp Asp Ala Ser Thr Val Ala Thr Leu Asp Ser Ile

440 445 450atc cac aaa tac gcc gcg cgc ggc aag agc gtg gag atc atc ggg ctc 1507Ile His Lys Tyr Ala Ala Arg Gly Lys Ser Val Glu Ile Ile Gly Leu

455460465 gac ggc ccc agc cgc gat agg ctt gag cgc cta tca ggc aag ctg ggc 1555Asp Gly Pro Ser Arg Asp Arg Leu Glu Arg Leu Ser Gly Lys Leu Gly 470475480485 taaaattg cttatcgacg cgc 1578<210>614<211>485<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>614Val Leu Ala Ser Phe Arg Phe Ala Phe Ser Ser Pro Arg Arg Phe Arg 151015 Thr Glu Val Leu Ala Gly Leu Val Val Ala Leu Ala Leu Ile Pro Glu

20 25 30Ser Ile Ala Phe Ser Val Leu Ala Gly Val Asp Pro Lys Met Gly Leu

35 40 45Phe Ala Ser Cys Thr Met Ala Met Thr Ile Ala Leu Thr Gly Gly Arg

50 55 60Pro Ala Met Ile Ser Ala Ala Thr Gly Ala Val Ala Leu Val Ile Ala 65 70 75 80Pro Val Val Arg Asp His Gly Val Glu Tyr Phe Leu Ala Thr Val Ile

85 90 95Leu Ala Gly Ile Ile Gln Ile Ala Leu Ser Leu Leu Gly Val Ala Lys

100 105 110Leu Met Arg Phe Ile Pro Arg Ser Val Met Leu Gly Phe Val Asn Ala

115 120 125Leu Ala Cys Leu Val Phe Phe Ala Gln Leu Pro His Leu Ile Asp Val

130 135 140Pro Trp Met Val Tyr Pro Leu Phe Ala Leu Gly Ile Gly Ile Met Leu145 150 155 160Phe Trp Pro Lys Leu Thr Ser Val Ile Pro Ala Pro Leu Ile Val Ile

165 170 175Val Ala Leu Thr Ala Ile Val Trp Val Phe Gly Ile Asn Ile Pro Asn

180 185 190Val Ser Asp Gln Gly Glu Leu Pro Ser Ser Leu Pro Glu Phe Leu Ile

195 200 205Pro Asn Val Pro Leu Thr Leu Glu Thr Leu Lys Ile Ile Gly Pro Tyr

210 215 220Ala Leu Gly Met Ser Leu Val Gly Leu Met Glu Ser Leu Leu Thr Ala225 230 235 240Lys Leu Val Asp Asp Ile Thr Glu Val His Ser Asn Lys Ser Arg Glu

245 250 255Ala Ala Gly Gln Gly Ile Ala Asn Ile Ile Thr Ala Phe Leu Gly Gly

260 265 270Met Gly Gly Cys Ala Met Ile Gly Gln Thr Met Ile Asn Val Lys Asn

275 280 285Ser Gly Ala Arg Thr Arg Leu Ser Thr Phe Leu Ala Gly Gly Phe Leu

290 295 300Leu Leu Leu Val Val Leu Leu Gly Asp Val Val Gly Lys Ile Pro Met305 310 315 320Ala Ala Leu Val Ala Val Met Ile Ile Val Ser Ile Asp Thr Ala Asp

325 330 335Trp His Ser Leu Asn Pro Arg Thr Leu Lys Phe Met Pro Leu Ser Glu

340 345 350Thr Ile Val Met Phe Ile Thr Ile Ile Ala Thr Leu Val Thr Gly Asn

355 360 365Leu Ala Ile Gly Val Ile Leu Gly Val Leu Thr Ala Met Val Met Phe

370 375 380Ala Arg Arg Val Ala His Leu Val Ser Val Glu Arg Thr Thr Asp Asn385 390 395 400Asn Ile Ser Thr Tyr Thr Val Lys Gly Gln Leu Phe Trp Ala Ser Ser

405 410 415Asn Asp Met Val Tyr Ser Phe Asp Tyr Ser Asp Glu Ala Glu Gln Ile

420 425 430Ile Ile Asp Leu Thr Ala Ala Glu Ile Trp Asp Ala Ser Thr Val Ala

435 440 445Thr Leu Asp Ser Ile Ile His Lys Tyr Ala Ala Arg Gly Lys Ser Val

450 455 460Glu Ile Ile Gly Leu Asp Gly Pro Ser Arg Asp Arg Leu Glu Arg Leu465 470 475 480Ser Gly Lys Leu Gly

485<210>615<211>1818<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1795)<223>RXA02128<400>615tattagcaaa acttcttaaa gagccttttt gtgcctttat ccgagtatct ttaaaagcat 60gagtattaag tgggcgcgct ttgtaccggg gataaccgcg atg cgg ggc tat caa 115

Met Arg Gly Tyr Gln

1 5cga tcc tgg ttg aag ggt gat gtc atc gcg ggt ata acc gtg gcc gcg 163Arg Ser Trp Leu Lys Gly Asp Val Ile Ala Gly Ile Thr Val Ala Ala

10 15 20tac ttg gtt cca caa gtc atg gct tat gcc gtc att gcg ggg ctg cca 211Tyr Leu Val Pro Gln Val Met Ala Tyr Ala Val Ile Ala Gly Leu Pro

25 30 35gct gtc gtt ggt ctg tgg gga gtt ctg gct ccc atg gcg ctg tac ttt 259Ala Val Val Gly Leu Trp Gly Val Leu Ala Pro Met Ala Leu Tyr Phe

40 45 50ttc ttg ggc acg tct cga aat ctc tcg gtt ggt cct gaa tca acc acc 307Phe Leu Gly Thr Ser Arg Asn Leu Ser Val Gly Pro Glu Ser Thr Thr

55 60 65gct ctg atg acg gct gca ggt gtg gga gct tta gtc ggg gca gct ggc 355Ala Leu Met Thr Ala Ala Gly Val Gly Ala Leu Val Gly Ala Ala Gly 70 75 80 85ggg cct gaa cga tac gca gaa gta gcg gca cta ttg gct att gca gtg 403Gly Pro Glu Arg Tyr Ala Glu Val Ala Ala Leu Leu Ala Ile Ala Val

90 95 100ggc att gta tgc gct gtt ggt ttt att ggc cga ttg gga ttt ctt acc 451Gly Ile Val Cys Ala Val Gly Phe Ile Gly Arg Leu Gly Phe Leu Thr

105 110 115agg ctg ttg tct cga ccg gtg ctc gtt gga tat ttg atc ggt att gca 499Arg Leu Leu Ser Arg Pro Val Leu Val Gly Tyr Leu Ile Gly Ile Ala

120 125 130gtc ttg atg atc gtc agt cag ctg tcc aaa gtc acc cag gtg aat gtg 547Val Leu Met Ile Val Ser Gln Leu Ser Lys Val Thr Gln Val Asn Val

135 140 145gag agc ggt cag acg tgg cag gaa ata ata tcg ttt atc aaa gta gct 595Glu Ser Gly Gln Thr Trp Gln Glu Ile Ile Ser Phe Ile Lys Val Ala150 155 160 165ggc cag gca cat att cct aca gtg att ttg gca gtc gtg gtg ttg agc 643Gly Gln Ala His Ile Pro Thr Val Ile Leu Ala Val Val Val Leu Ser

170 175 180ttg ctg tat ctg gca aat tgg ttg acg cct aaa ttt ccc agc aca ctc 691Leu Leu Tyr Leu Ala Asn Trp Leu Thr Pro Lys Phe Pro Ser Thr Leu

185 190 195atg gtt ctt ctg ctt tcg gca gcc gcg gtg ggg ttt ttt cat ctg gat 739Met Val Leu Leu Leu Ser Ala Ala Ala Val Gly Phe Phe His Leu Asp

200 205 210agg ttt ggt ctt gag gtc att ggt gag gtg ccc cgt ggc ctg cct caa 787Arg Phe Gly Leu Glu Val Ile Gly Glu Val Pro Arg Gly Leu Pro Gln

215 220 225cca agt att ccc tcg att ggc gat cta gag atc tgg tcg ttg ttg ccc 835Pro Ser Ile Pro Ser Ile Gly Asp Leu Glu Ile Trp Ser Leu Leu Pro230 235 240 245tat gcc gtg ggt att gcc atc gtt ggt ttt tca gac aat gtg ttg act 883Tyr Ala Val Gly Ile Ala Ile Val Gly Phe Ser Asp Asn Val Leu Thr

250 255 260gct cgt gca ttc gcg tcg gga aaa gat gag gtg att gat tcc aac cag 931Ala Arg Ala Phe Ala Ser Gly Lys Asp Glu Val Ile Asp Ser Asn Gln

265 270 275gag ctg ctc gca ctg gga acc gca aac ctg gcg aat ggg ttc ttc cag 979Glu Leu Leu Ala Leu Gly Thr Ala Asn Leu Ala Asn Gly Phe Phe Gln

280 285 290gga ttt cct gtg tca tcg agt ggc tcc cga act gtt ctt gga gac acg 1027Gly Phe Pro Val Ser Ser Ser Gly Ser Arg Thr Val Leu Gly Asp Thr

295 300 305gca ggt gct cgc act cag gtg cat tca ctt gtc gtg gtg gcg ctg gtg 1075Ala Gly Ala Arg Thr Gln Val His Ser Leu Val Val Val Ala Leu Val310 315 320 325atc atg gtg ctg ttg ttt gct ggt cct gtg ctc gag tct ttc cca gat 1123Ile Met Val Leu Leu Phe Ala Gly Pro Val Leu Glu Ser Phe Pro Asp

330 335 340gcg gca ctt ggc gcc tta gtt att tat gca gca acg cag ttg att gat 1171Ala Ala Leu Gly Ala Leu Val Ile Tyr Ala Ala Thr Gln Leu Ile Asp

345 350 355atc gca gag atc aaa agg atc gca cgt ttc cgc aag agc gag ttg gtc 1219Ile Ala Glu Ile Lys Arg Ile Ala Arg Phe Arg Lys Ser Glu Leu Val

360 365 370atc aca gcg gct act gct gca tcc gtt gtg gct tct ggc gtg ctc gcg 1267Ile Thr Ala Ala Thr Ala Ala Ser Val Val Ala Ser Gly Val Leu Ala

375 380 385ggg atc ggc gtt gcg gtt acg ttg tcc atc ttg gat ctc atc aga cgt 1315Gly Ile Gly Val Ala Val Thr Leu Ser Ile Leu Asp Leu Ile Arg Arg390 395 400 405att acc cga cct tat gcc gat gtc cta gga tat acg ccg ggc atg gct 1363Ile Thr Arg Pro Tyr Ala Asp Val Leu Gly Tyr Thr Pro Gly Met Ala

410 415 420gga atg cac agc ttg gag gat tat cct gag tcg aca gca gtc gaa ggg 1411Gly Met His Ser Leu Glu Asp Tyr Pro Glu Ser Thr Ala Val Glu Gly

425 430 435ctc gtg gtt ttt aga tac gat tcc cca ctg ttt ttc gcc aac gct gat 1459Leu Val Val Phe Arg Tyr Asp Ser Pro Leu Phe Phe Ala Asn Ala Asp

440 445 450gat ttt tcc aaa cgt gcc atc gaa gcc gtt gat gaa gca act caa ccc 1507Asp Phe Ser Lys Arg Ala Ile Glu Ala Val Asp Glu Ala Thr Gln Pro

455 460 465gtg cat tgg ttt tta ctg aat gct gaa gcg aat acg gaa gtt gat ctc 1555Val His Trp Phe Leu Leu Asn Ala Glu Ala Asn Thr Glu Val Asp Leu470 475 480 485acg gcc gtc gat gcc atg gaa gca ctt cgc aaa acc ctg gag gaa cgg 1603Thr Ala Val Asp Ala Met Glu Ala Leu Arg Lys Thr Leu Glu Glu Arg

490 495 500ggt atc cga ttt gcg atg gcc cgg gtg aag caa gat cta cgc cga agc 1651Gly Ile Arg Phe Ala Met Ala Arg Val Lys Gln Asp Leu Arg Arg Ser

505 510 515ctc gag cct gca ggt ttc att gaa tcc gtg ggg gag gag tac att ttc 1699Leu Glu Pro Ala Gly Phe Ile Glu Ser Val Gly Glu Glu Tyr Ile Phe

520 525 530gcc aca ctc ccc act gca gtc aag ggg tat tcc gtg gag ttt cgc gat 1747Ala Thr Leu Pro Thr Ala Val Lys Gly Tyr Ser Val Glu Phe Arg Asp

535540545 cgt ttt gga aac tat cca gaa ggc gtt ccg aaa gaa att ttg gaa ctt 1795Arg Phe Gly Asn Tyr Pro Glu Gly Val Pro Lys Glu Ile Leu Glu Leu 550555560565 taagctgcct ggttggcgga ctt 1818<210>616<211>565<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>616Met Arg Gly Tyr Gln Arg Ser Trp Leu Lys Gly Asp Val Ile Ala Gly 151015 Ile Thr Val Ala Ala Tyr Leu Val Pro Gln Val Met Ala Tyr Ala Val

20 25 30Ile Ala Gly Leu Pro Ala Val Val Gly Leu Trp Gly Val Leu Ala Pro

35 40 45Met Ala Leu Tyr Phe Phe Leu Gly Thr Ser Arg Asn Leu Ser Val Gly

50 55 60Pro Glu Ser Thr Thr Ala Leu Met Thr Ala Ala Gly Val Gly Ala Leu 65 70 75 80Val Gly Ala Ala Gly Gly Pro Glu Arg Tyr Ala Glu Val Ala Ala Leu

85 90 95Leu Ala Ile Ala Val Gly Ile Val Cys Ala Val Gly Phe Ile Gly Arg

100 105 110Leu Gly Phe Leu Thr Arg Leu Leu Ser Arg Pro Val Leu Val Gly Tyr

115 120 125Leu Ile Gly Ile Ala Val Leu Met Ile Val Ser Gln Leu Ser Lys Val

130 135 140Thr Gln Val Asn Val Glu Ser Gly Gln Thr Trp Gln Glu Ile Ile Ser145 150 155 160Phe Ile Lys Val Ala Gly Gln Ala His Ile Pro Thr Val Ile Leu Ala

165 170 175Val Val Val Leu Ser Leu Leu Tyr Leu Ala Asn Trp Leu Thr Pro Lys

180 185 190Phe Pro Ser Thr Leu Met Val Leu Leu Leu Ser Ala Ala Ala Val Gly

195 200 205Phe Phe His Leu Asp Arg Phe Gly Leu Glu Val Ile Gly Glu Val Pro

210 215 220Arg Gly Leu Pro Gln Pro Ser Ile Pro Ser Ile Gly Asp Leu Glu Ile225 230235 240Trp Ser Leu Leu Pro Tyr Ala Val Gly Ile Ala Ile Val Gly Phe Ser

245 250 255Asp Asn Val Leu Thr Ala Arg Ala Phe Ala Ser Gly Lys Asp Glu Val

260 265 270Ile Asp Ser Asn Gln Glu Leu Leu Ala Leu Gly Thr Ala Asn Leu Ala

275 280 285Asn Gly Phe Phe Gln Gly Phe Pro Val Ser Ser Ser Gly Ser Arg Thr

290 295 300Val Leu Gly Asp Thr Ala Gly Ala Arg Thr Gln Val His Ser Leu Val305 310 315 320Val Val Ala Leu Val Ile Met Val Leu Leu Phe Ala Gly Pro Val Leu

325 330 335Glu Ser Phe Pro Asp Ala Ala Leu Gly Ala Leu Val Ile Tyr Ala Ala

340 345 350Thr Gln Leu Ile Asp Ile Ala Glu Ile Lys Arg Ile Ala Arg Phe Arg

355 360 365Lys Ser Glu Leu Val Ile Thr Ala Ala Thr Ala Ala Ser Val Val Ala

370 375 380Ser Gly Val Leu Ala Gly Ile Gly Val Ala Val Thr Leu Ser Ile Leu385 390 395 400Asp Leu Ile Arg Arg Ile Thr Arg Pro Tyr Ala Asp Val Leu Gly Tyr

405 410 415Thr Pro Gly Met Ala Gly Met His Ser Leu Glu Asp Tyr Pro Glu Ser

420 425 430Thr Ala Val Glu Gly Leu Val Val Phe Arg Tyr Asp Ser Pro Leu Phe

435 440 445Phe Ala Asn Ala Asp Asp Phe Ser Lys Arg Ala Ile Glu Ala Val Asp

450 455 460Glu Ala Thr Gln Pro Val His Trp Phe Leu Leu Asn Ala Glu Ala Asn465 470 475 480Thr Glu Val Asp Leu Thr Ala Val Asp Ala Met Glu Ala Leu Arg Lys

485 490 495Thr Leu Glu Glu Arg Gly Ile Arg Phe Ala Met Ala Arg Val Lys Gln

500 505 510Asp Leu Arg Arg Ser Leu Glu Pro Ala Gly Phe Ile Glu Ser Val Gly

515 520 525Glu Glu Tyr Ile Phe Ala Thr Leu Pro Thr Ala Val Lys Gly Tyr Ser

530 535 540Val Glu Phe Arg Asp Arg Phe Gly Asn Tyr Pro Glu Gly Val Pro Lys545 550 555 560Glu Ile Leu Glu Leu

565<210>617<211>1734<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1711)<223>RXA02634<400>617caacgcgaag gcttagttgt ttattaccgg ctcacctacc cggaggtcgc agactttctt 60aaggtgagcc gctcactatt aaagaggatg gctggcgaag atg cgt gac ctt tta 115

Met Arg Asp Leu Leu

1 5ccc tct aga gac gac tat cag cra ctc cgc ttc tcc tgg aag atg gac 163Pro Ser Arg Asp Asp Tyr Gln Leu Leu Arg Phe Ser Trp Lys Met Asp

10 15 20att gct gct ggc gtc acc gtg ggc att gtt gcc ctc ccc ctc gct ctc 211Ile Ala Ala Gly Val Thr Val Gly Ile Val Ala Leu Pro Leu Ala Leu

25 30 35gcc ttt ggt gtg agt tct gga gtc gga gcc gag gca gga tta gtg act 259Ala Phe Gly Val Ser Ser Gly Val Gly Ala Glu Ala Gly Leu Val Thr

40 45 50gcg att att gct ggc ctg gtt gca gca atc ttc ggc ggt tcc aat gtg 307Ala Ile Ile Ala Gly Leu Val Ala Ala Ile Phe Gly Gly Ser Asn Val

55 60 65cag gtt tca gga cca aca gga gcg atg gtg gtt gtt ctc gct cca atc 355Gln Val Ser Gly Pro Thr Gly Ala Met Val Val Val Leu Ala Pro Ile 70 75 80 85gtc gcc caa tat ggt gtc ggt gcg gtt gca tta ctc agc ctg atg gct 403Val Ala Gln Tyr Gly Val Gly Ala Val Ala Leu Leu Ser Leu Met Ala

90 95 100gga gtt atc gtc ctt gtc gcc gga gtg ctt cga tta ggc cga acg gtg 451Gly Val Ile Val Leu Val Ala Gly Val Leu Arg Leu Gly Arg Thr Val

105 110 115agt ttc att ccg tgg ccg gtc atc gaa gga ttt acg gca ggc atc ggt 499Ser Phe Ile Pro Trp Pro Val Ile Glu Gly Phe Thr Ala Gly Ile Gly

120 125 130gtg att att ttc ctg caa cag gtg cca gct gcg ttt ggt tat tcg ggc 547Val Ile Ile Phe Leu Gln Gln Val Pro Ala Ala Phe Gly Tyr Ser Gly

135 140 145cat ttg ccc acc aat gcg ctc ctc gct gcg att cac act gtt tca cac 595His Leu Pro Thr Asn Ala Leu Leu Ala Ala Ile His Thr Val Ser His150 155 160 165gcc acg aag gac gca att cra cct ctc tta att att atc gtc acc gct 643Ala Thr Lys Asp Ala Ile Leu Pro Leu Leu Ile Ile Ile Val Thr Ala

170 175 180gcg atc atg att gtg ttg gga aag atc gcc cca aag ctc cct gcc agc 691Ala Ile Met Ile Val Leu Gly Lys Ile Ala Pro Lys Leu Pro Ala Ser

185190 195ttc att gcc att ttg gtg gtg tcc att ggc gtg gct ctg ctc aag ctt 739Phe Ile Ala Ile Leu Val Val Ser Ile Gly Val Ala Leu Leu Lys Leu

200 205 210ccc gtt gag ttg atc ggt gag ctc ccc aat tcc ctt cct gcc cct cac 787Pro Val Glu Leu Ile Gly Glu Leu Pro Asn Ser Leu Pro Ala Pro His

215 220 225ctg cct gat gtg aac ctg gag atg ttc acg agt ttg ctg ggg cca gct 835Leu Pro Asp Val Asn Leu Glu Met Phe Thr Ser Leu Leu Gly Pro Ala230 235 240 245ttt gct gtc gcc gcg ctc gct gct att gag tct ctc ctt tcc gct cgt 883Phe Ala Val Ala Ala Leu Ala Ala Ile Glu Ser Leu Leu Ser Ala Arg

250 255 260gtg gca gcc tcc atg gcc gat acg ggt cct tat aat gct gac cgc gaa 931Val Ala Ala Ser Met Ala Asp Thr Gly Pro Tyr Asn Ala Asp Arg Glu

265 270 275ttg gtc ggt cag ggg ttg gcg tcg ata agc gct ggc ttt ttt ggc ggc 979Leu Val Gly Gln Gly Leu Ala Ser Ile Ser Ala Gly Phe Phe Gly Gly

280 285 290atg ccg gca act ggc gca atc gcg cgt acg gcg gtc aat gtg cgc tcc 1027Met Pro Ala Thr Gly Ala Ile Ala Arg Thr Ala Val Asn Val Arg Ser

295 300 305ggc ggg cgt acc cgt ata gcg tcg att att cac gcg ctt gtg ctg ctc 1075Gly Gly Arg Thr Arg Ile Ala Ser Ile Ile His Ala Leu Val Leu Leu310 315 320 325ggc gtt gtg tat gtg gcg gcg aat atc gtt gcg gtc att ccg ctc gcc 1123Gly Val Val Tyr Val Ala Ala Asn Ile Val Ala Val Ile Pro Leu Ala

330 335 340gca ctg tcg ggc gtg ctc atg gtc acc gcg agc cgc atg gtg tcc att 1171Ala Leu Ser Gly Val Leu Met Val Thr Ala Ser Arg Met Val Ser Ile

345 350 355gaa gtg atc tcg cgc gtc atg cgc tcc act cgc tct gat gcg atc gtt 1219Glu Val Ile Ser Arg Val Met Arg Ser Thr Arg Ser Asp Ala Ile Val

360 365 370ttt gtc atc acc gcg atc gtc acc atc agc gtc gac ctc gtc att gcg 1267Phe Val Ile Thr Ala Ile Val Thr Ile Ser Val Asp Leu Val Ile Ala

375 380 385gtc ggc atc ggc att gcc gtc gcg acg ttc ttc atg ctg cga cgc atg 1315Val Gly Ile Gly Ile Ala Val Ala Thr Phe Phe Met Leu Arg Arg Met390 395 400 405agc atg aac gcc ggc gtc ttc cgg gaa acc ttg ccc gaa ccg gcc acg 1363Ser Met Asn Ala Gly Val Phe Arg Glu Thr Leu Pro Glu Pro Ala Thr

410 415 420ctt aac gac gaa aag atc ggc ctt ttc cgt atc gag ggc gca ttg ttc 1411Leu Asn Asp Glu Lys Ile Gly Leu Phe Arg Ile Glu Gly Ala Leu Phe

425 430 435ttt ggc gca gct gaa cgt ctt tcg cag caa atc ctt gat tat gag gac 1459Phe Gly Ala Ala Glu Arg Leu Ser Gln Gln Ile Leu Asp Tyr Glu Asp

440 445 450ctc gaa gtg gtg atc ctg cgc ctg tca cac atc caa atg atc gac gcc 1507Leu Glu Val Val Ile Leu Arg Leu Ser His Ile Gln Met Ile Asp Ala

455 460 465acc ggc gcc cac cag ctc acc gag ctt gtc aat gcg ctg gaa aga aaa 1555Thr Gly Ala His Gln Leu Thr Glu Leu Val Asn Ala Leu Glu Arg Lys470 475 480 485aat gtc act gta tta att aag ggc gtc cgg aaa gaa cac att cac gtt 1603Asn Val Thr Val Leu Ile Lys Gly Val Arg Lys Glu His Ile His Val

490495 500ctc ggc gtc ctc gga gcg atc aga tca ctg cgg cat gag aac cac ctc 1651Leu Gly Val Leu Gly Ala Ile Arg Ser Leu Arg His Glu Asn His Leu

505 510 515ttc gat gac ctt gcc cca gcg gtt gaa cat gcc cga aaa cac gtt aag 1699Phe Asp Asp Leu Ala Pro Ala Val Glu His Ala Arg Lys His Val Lys

520 525 530atc gac aac agt taaggcttcc ggggcgatct aaa 1734Ile Asp Asn Ser

535<210>618<211>537<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>618Met Arg Asp Leu Leu Pro Ser Arg Asp Asp Tyr Gln Leu Leu Arg Phe 151015 Ser Trp Lys Met Asp Ile Ala Ala Gly Val Thr Val Gly Ile Val Ala

20 25 30Leu Pro Leu Ala Leu Ala Phe Gly Val Ser Ser Gly Val Gly Ala Glu

35 40 45Ala Gly Leu Val Thr Ala Ile Ile Ala Gly Leu Val Ala Ala Ile Phe

50 55 60Gly Gly Ser Asn Val Gln Val Ser Gly Pro Thr Gly Ala Met Val Val 65 70 75 80Val Leu Ala Pro Ile Val Ala Gln Tyr Gly Val Gly Ala Val Ala Leu

85 90 95Leu Ser Leu Met Ala Gly Val Ile Val Leu Val Ala Gly Val Leu Arg

100 105 110Leu Gly Arg Thr Val Ser Phe Ile Pro Trp Pro Val Ile Glu Gly Phe

115 120 125Thr Ala Gly Ile Gly Val Ile Ile Phe Leu Gln Gln Val Pro Ala Ala

130 135 140Phe Gly Tyr Ser Gly His Leu Pro Thr Asn Ala Leu Leu Ala Ala Ile145 150 155 160His Thr Val Ser His Ala Thr Lys Asp Ala Ile Leu Pro Leu Leu Ile

165 170 175Ile Ile Val Thr Ala Ala Ile Met Ile Val Leu Gly Lys Ile Ala Pro

180 185 190Lys Leu Pro Ala Ser Phe Ile Ala Ile Leu Val Val Ser Ile Gly Val

195 200 205Ala Leu Leu Lys Leu Pro Val Glu Leu Ile Gly Glu Leu Pro Asn Ser

210 215 220Leu Pro Ala Pro His Leu Pro Asp Val Asn Leu Glu Met Phe Thr Ser225 230 235 240Leu Leu Gly Pro Ala Phe Ala Val Ala Ala Leu Ala Ala Ile Glu Ser

245 250 255Leu Leu Ser Ala Arg Val Ala Ala Ser Met Ala Asp Thr Gly Pro Tyr

260 265 270Asn Ala Asp Arg Glu Leu Val Gly Gln Gly Leu Ala Ser Ile Ser Ala

275 280 285Gly Phe Phe Gly Gly Met Pro Ala Thr Gly Ala Ile Ala Arg Thr Ala

290 295 300Val Asn Val Arg Ser Gly Gly Arg Thr Arg Ile Ala Ser Ile Ile His305 310 315 320Ala Leu Val Leu Leu Gly Val Val Tyr Val Ala Ala Asn Ile Val Ala

325 330 335Val Ile Pro Leu Ala Ala Leu Ser Gly Val Leu Met Val Thr Ala Ser

340 345 350Arg Met Val Ser Ile Glu Val Ile Ser Arg Val Met Arg Ser Thr Arg

355 360 365Ser Asp Ala Ile Val Phe Val Ile Thr Ala Ile Val Thr Ile Ser Val

370 375 380Asp Leu Val Ile Ala Val Gly Ile Gly Ile Ala Val Ala Thr Phe Phe385 390 395 400Met Leu Arg Arg Met Ser Met Asn Ala Gly Val Phe Arg Glu Thr Leu

405 410 415Pro Glu Pro Ala Thr Leu Asn Asp Glu Lys Ile Gly Leu Phe Arg Ile

420 425 430Glu Gly Ala Leu Phe Phe Gly Ala Ala Glu Arg Leu Ser Gln Gln Ile

435 440 445Leu Asp Tyr Glu Asp Leu Glu Val Val Ile Leu Arg Leu Ser His Ile

450 455 460Gln Met Ile Asp Ala Thr Gly Ala His Gln Leu Thr Glu Leu Val Asn465 470 475 480Ala Leu Glu Arg Lys Asn Val Thr Val Leu Ile Lys Gly Val Arg Lys

485 490 495Glu His Ile His Val Leu Gly Val Leu Gly Ala Ile Arg Ser Leu Arg

500 505 510His Glu Asn His Leu Phe Asp Asp Leu Ala Pro Ala Val Glu His Ala

515 520 525Arg Lys His Val Lys Ile Asp Asn Ser

530535<210>619<211>1410<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1387)<223>RXN02233<400>619atccccaccc aattggccca agagctgcag agttacgttg tagaacccac ctctgcctaa 60ctgtcgattt cccaagagcc cccttgggag tcgataatta gtg ctc gtg act tca 115

Val Leu Val Thr Ser

15aca tgg gga tgg acc gtc cac gga gac ggc aaa aag atc gaa ccc ggc 163Thr Trp Gly Trp Thr Val His Gly Asp Gly Lys Lys Ile Glu Pro Gly

10 15 20gca gtt gtc gct cct aaa gag cgc ctg agc tgg ggg cgc aca att gga 211Ala Val Val Ala Pro Lys Glu Arg Leu Ser Trp Gly Arg Thr Ile Gly

25 30 35atc ggt atg cag cac gtg atc gcc atg ttc ggc gcc acg ctc ctg gtt 259Ile Gly Met Gln His Val Ile Ala Met Phe Gly Ala Thr Leu Leu Val

40 45 50ccc aca ctc acc gga ttt ccg gtc aac acc aca ctt tta ttc tct ggt 307Pro Thr Leu Thr Gly Phe Pro Val Asn Thr Thr Leu Leu Phe Ser Gly

55 60 65ctg gga aca atc ctg ttc ctg ttg atc acc aga aac cga cta ccc tcg 355Leu Gly Thr Ile Leu Phe Leu Leu Ile Thr Arg Asn Arg Leu Pro Ser 70 75 80 85tac ctg ggt agt tct ttt gct ttc att gca cct tta acc gca acc caa 403Tyr Leu Gly Ser Ser Phe Ala Phe Ile Ala Pro Leu Thr Ala Thr Gln

90 95 100gtc cat ggc att ggc gtg cag atc ggt ggc att ctt gtc gca ggt ctc 451Val His Gly Ile Gly Val Gln Ile Gly Gly Ile Leu Val Ala Gly Leu

105 110 115gtg ctc gtc gcc att gga ttt gtg gtg aaa gca gcg ggc aaa cgc gtt 499Val Leu Val Ala Ile Gly Phe Val Val Lys Ala Ala Gly Lys Arg Val

120 125 130att gat gct gtc atg cca ccc gct gtc acc ggt gcg atc gtg gca ctc 547Ile Asp Ala Val Met Pro Pro Ala Val Thr Gly Ala Ile Val Ala Leu

135 140 145atc ggc ctg aac ctg gca cca acc gcg gca gga aac ttc tcc agc caa 595Ile Gly Leu Asn Leu Ala Pro Thr Ala Ala Gly Asn Phe Ser Ser Gln150 155 160 165cca ctg gtt gcc acg gcg acc ctc ttt gcc att ttg atc gct acc gtt 643Pro Leu Val Ala Thr Ala Thr Leu Phe Ala Ile Leu Ile Ala Thr Val

170 175 180gca ggc cgc gga atg att gct cgc ctg ggc att ttg atc ggt gtg gtg 691Ala Gly Arg Gly Met Ile Ala Arg Leu Gly Ile Leu Ile Gly Val Val

185 190 195atc ggc tgg gtt ttc gca gct atc acc ggc aac ctc tca gaa ggc gca 739Ile Gly Trp Val Phe Ala Ala Ile Thr Gly Asn Leu Ser Glu Gly Ala

200 205 210gca gac acc atc cgt gaa gca gca tgg ttc gga ctg cca cag ttc cac 787Ala Asp Thr Ile Arg Glu Ala Ala Trp Phe Gly Leu Pro Gln Phe His

215 220 225aag ccg gaa ttc cag ctc tct gcc att ttg gtg aca ctg cca gtc atc 835Lys Pro Glu Phe Gln Leu Ser Ala Ile Leu Val Thr Leu Pro Val Ile230 235 240 245atc gtg ctc atc gct gaa aac gtc ggc cac gtc aaa gca gtc tca gag 883Ile Val Leu Ile Ala Glu Asn Val Gly His Val Lys Ala Val Ser Glu

250 255 260atg aca ggg gag gac ctc gac gac ctc gcc ggc gac gca ctt atc gca 931Met Thr Gly Glu Asp Leu Asp Asp Leu Ala Gly Asp Ala Leu Ile Ala

265 270 275gac gga ttc ggc acc acc ctc gca ggt gcc ttc ggt gga tcc ggc acc 979Asp Gly Phe Gly Thr Thr Leu Ala Gly Ala Phe Gly Gly Ser Gly Thr

280 285 290acc acc tac gca gaa aac atc ggc gtc atg gcg gcc acc cgc gta tat 1027Thr Thr Tyr Ala Glu Asn Ile Gly Val Met Ala Ala Thr Arg Val Tyr

295300 305tcc acc gct gcg tac tgg gtt gcc gcg tgc act gcc atc gcc ctt gcc 1075Ser Thr Ala Ala Tyr Trp Val Ala Ala Cys Thr Ala Ile Ala Leu Ala310 315 320 325ttc atc ccc aaa ttc ggt gca ctg atc ttc acc atc ccc gcc ggc gtg 1123Phe Ile Pro Lys Phe Gly Ala Leu Ile Phe Thr Ile Pro Ala Gly Val

330 335 340ctg ggt ggg gca tgt ttg gtt ctt tac ggc cta atc ggt atg crc ggc 1171Leu Gly Gly Ala Cys Leu Val Leu Tyr Gly Leu Ile Gly Met Leu Gly

345 350 355att cgt atc tgg caa gac aac aag gtc aac ttc aac aat cca gtg aat 1219Ile Arg Ile Trp Gln Asp Asn Lys Val Asn Phe Asn Asn Pro Val Asn

360 365 370ctg acc atg gct gcc gtt gct ttg gtt gca ggc att ggt aac ctc acc 1267Leu Thr Met Ala Ala Val Ala Leu Val Ala Gly Ile Gly Asn Leu Thr

375 380 385ctc acc gtt ttc gga gtc act ctt gaa ggc atc gca tgg ggc tct gta 1315Leu Thr Val Phe Gly Val Thr Leu Glu Gly Ile Ala Trp Gly Ser Val390 395 400 405ggc atc att gtg ctg tac cca atc atg aag cgc ctg tac ctt tcc att 1363Gly Ile Ile Val Leu Tyr Pro Ile Met Lys Arg Leu Tyr Leu Ser Ile

410 415 420ggg gaa ggc aag aac gca aag ttc tagtacgctg ctaaagtatg cag 1410Gly Glu Gly Lys Asn Ala Lys Phe

425<210>620<211>429<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>620Val Leu Val Thr Ser Thr Trp Gly Trp Thr Val His Gly Asp Gly Lys 151015 Lys Ile Glu Pro Gly Ala Val Val Ala Pro Lys Glu Arg Leu Ser Trp

20 25 30Gly ArgThr Ile Gly Ile Gly Met Gln His Val Ile Ala Met Phe Gly

35 40 45Ala Thr Leu Leu Val Pro Thr Leu Thr Gly Phe Pro Val Asn Thr Thr

50 55 60Leu Leu Phe Ser Gly Leu Gly Thr Ile Leu Phe Leu Leu Ile Thr Arg 65 70 75 80Asn Arg Leu Pro Ser Tyr Leu Gly Ser Ser Phe Ala Phe Ile Ala Pro

85 90 95Leu Thr Ala Thr Gln Val His Gly Ile Gly Val Gln Ile Gly Gly Ile

100 105 110Leu Val Ala Gly Leu Val Leu Val Ala Ile Gly Phe Val Val Lys Ala

115 120 125Ala Gly Lys Arg Val Ile Asp Ala Val Met Pro Pro Ala Val Thr Gly

130 135 140Ala Ile Val Ala Leu Ile Gly Leu Asn Leu Ala Pro Thr Ala Ala Gly145 150 155 160Asn Phe Ser Ser Gln Pro Leu Val Ala Thr Ala Thr Leu Phe Ala Ile

165 170 175Leu Ile Ala Thr Val Ala Gly Arg Gly Met Ile Ala Arg Leu Gly Ile

180 185 190Leu Ile Gly Val Val Ile Gly Trp Val Phe Ala Ala Ile Thr Gly Asn

195 200 205Leu Ser Glu Gly Ala Ala Asp Thr Ile Arg Glu Ala Ala Trp Phe Gly

210 215 220Leu Pro Gln Phe His Lys Pro Glu Phe Gln Leu Ser Ala Ile Leu Val225 230 235 240Thr Leu Pro Val Ile Ile Val Leu Ile Ala Glu Asn Val Gly His Val

245 250255Lys Ala Val Ser Glu Met Thr Gly Glu Asp Leu Asp Asp Leu Ala Gly

260 265 270Asp Ala Leu Ile Ala Asp Gly Phe Gly Thr Thr Leu Ala Gly Ala Phe

275 280 285Gly Gly Ser Gly Thr Thr Thr Tyr Ala Glu Asn Ile Gly Val Met Ala

290 295 300Ala Thr Arg Val Tyr Ser Thr Ala Ala Tyr Trp Val Ala Ala Cys Thr305 310 315 320Ala Ile Ala Leu Ala Phe Ile Pro Lys Phe Gly Ala Leu Ile Phe Thr

325 330 335Ile Pro Ala Gly Val Leu Gly Gly Ala Cys Leu Val Leu Tyr Gly Leu

340 345 350Ile Gly Met Leu Gly Ile Arg Ile Trp Gln Asp Asn Lys Val Asn Phe

355 360 365Asn Asn Pro Val Asn Leu Thr Met Ala Ala Val Ala Leu Val Ala Gly

370 375 380Ile Gly Asn Leu Thr Leu Thr Val Phe Gly Val Thr Leu Glu Gly Ile385 390 395 400Ala Trp Gly Ser Val Gly Ile Ile Val Leu Tyr Pro Ile Met Lys Arg

405 410 415Leu Tyr Leu Ser Ile Gly Glu Gly Lys Asn Ala Lys Phe

420425<210>621<211>1335<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1312)<223>FRXA02233<400>621atccccaccc aattggccca agagctgcag agttacgttg tagaacccac ctctgcctaa 60ctgtcgattt cccaagagcc cccttgggag tcgataatta gtg ctc gtg act tca 115

Val Leu Val Thr Ser

1 5aca tgg gga tgg acc gtc cac gga gac ggc aaa aag atc gaa ccc ggc 163Thr Trp Gly Trp Thr Val His Gly Asp Gly Lys Lys Ile Glu Pro Gly

10 15 20gca gtt gtc gct cct aaa gag cgc ctg agc tgg ggg cgc aca att gga 211Ala Val Val Ala Pro Lys Glu Arg Leu Ser Trp Gly Arg Thr Ile Gly

25 30 35atc ggt atg cag cac gtg atc gcc atg ttc ggc gcc acg ctc ctg gtt 259Ile Gly Met Gln His Val Ile Ala Met Phe Gly Ala Thr Leu Leu Val

40 45 50ccc aca ctc acc gga ttt ccg gtc aac acc aca ctt tta ttc tct ggt 307Pro Thr Leu Thr Gly Phe Pro Val Asn Thr Thr Leu Leu Phe Ser Gly

55 60 65ctg gga aca atc ctg ttc ctg ttg atc acc aga aac cga cta ccc tcg 355Leu Gly Thr Ile Leu Phe Leu Leu Ile Thr Arg Asn Arg Leu Pro Ser 70 75 80 85tac ctg ggt agt tct ttt gct ttc att gca cct tta acc gca acc caa 403Tyr Leu Gly Ser Ser Phe Ala Phe Ile Ala Pro Leu Thr Ala Thr Gln

90 95 100gtc cat ggc att ggc gtg cag atc ggt ggc att ctt gtc gca ggt ctc 451Val His Gly Ile Gly Val Gln Ile Gly Gly Ile Leu Val Ala Gly Leu

105 110 115gtg ctc gtc gcc att gga ttt gtg gtg aaa gca gcg ggc aaa cgc gtt 499Val Leu Val Ala Ile Gly Phe Val Val Lys Ala Ala Gly Lys Arg Val

120 125 130att gat gct gtc atg cca ccc gct gtc acc ggt gcg atc gtg gca ctc 547Ile Asp Ala Val Met Pro Pro Ala Val Thr Gly Ala Ile Val Ala Leu

135 140 145atc ggc ctg aac ctg gca cca acc gcg gcagga aac ttc tcc agc caa 595Ile Gly Leu Asn Leu Ala Pro Thr Ala Ala Gly Asn Phe Ser Ser Gln150 155 160 165cca ctg gtt gcc acg gcg acc ctc ttt gcc att ttg atc gct acc gtt 643Pro Leu Val Ala Thr Ala Thr Leu Phe Ala Ile Leu Ile Ala Thr Val

170 175 180gca ggc cgc gga atg att gct cgc ctg ggc att ttg atc ggt gtg gtg 691Ala Gly Arg Gly Met Ile Ala Arg Leu Gly Ile Leu Ile Gly Val Val

185 190 195atc ggc tgg gtt ttc gca gct atc acc ggc aac ctc tca gaa ggc gca 739Ile Gly Trp Val Phe Ala Ala Ile Thr Gly Asn Leu Ser Glu Gly Ala

200 205 210gca gac acc atc cgt gaa gca gca tgg ttc gga ctg cca cag ttc cac 787Ala Asp Thr Ile Arg Glu Ala Ala Trp Phe Gly Leu Pro Gln Phe His

215 220 225aag ccg gaa ttc cag ctc tct gcc att ttg gtg aca ctg cca gtc atc 835Lys Pro Glu Phe Gln Leu Ser Ala Ile Leu Val Thr Leu Pro Val Ile230 235 240 245atc gtg ctc atc gct gaa aac gtc ggc cac gtc aaa gca gtc tca gag 883Ile Val Leu Ile Ala Glu Asn Val Gly His Val Lys Ala Val Ser Glu

250 255 260atg aca ggg gag gac ctc gac gac ctc gcc ggc gac gca ctt atc gca 931Met Thr Gly Glu Asp Leu Asp Asp Leu Ala Gly Asp Ala Leu Ile Ala

265 270 275gac gga ttc ggc acc acc ctc gca ggt gcc ttc ggt gga tcc ggc acc 979Asp Gly Phe Gly Thr Thr Leu Ala Gly Ala Phe Gly Gly Ser Gly Thr

280 285 290acc acc tac gca gaa aac atc ggc gtc atg gcg gcc acc cgc gta tat 1027Thr Thr Tyr Ala Glu Asn Ile Gly Val Met Ala Ala Thr Arg Val Tyr

295 300 305tcc acc gct gcg tac tgg gtt gcc gcg tgc act gcc atc gcc ctt gcc 1075Ser Thr Ala Ala Tyr Trp Val Ala Ala Cys Thr Ala Ile Ala Leu Ala310 315 320 325ttc atc ccc aaa ttc ggt gca ctg atc ttc acc atc ccc gcc ggc gtg 1123Phe Ile Pro Lys Phe Gly Ala Leu Ile Phe Thr Ile Pro Ala Gly Val

330 335 340ctg ggt ggg gca tgt ttg gtt ctt tac ggc cta atc ggt atg ctc ggc 1171Leu Gly Gly Ala Cys Leu Val Leu Tyr Gly Leu Ile Gly Met Leu Gly

345 350 355att cgt atc tgg caa gac aac aag gtc aac ttc aac aat cca gtg aat 1219Ile Arg Ile Trp Gln Asp Asn Lys Val Asn Phe Asn Asn Pro Val Asn

360 365 370ctg acc atg gct gcc gtt gct ttg gtt gca ggc att ggt aac ctc acc 1267Leu Thr Met Ala Ala Val Ala Leu Val Ala Gly Ile Gly Asn Leu Thr

375380385 ctc acc gtt ttc gga gtc act ctt gaa ggc atc gca tgg gct ctg 1312Leu Thr Val Phe Gly Val Thr Leu Glu Gly Ile Ala Trp Ala Leu 390395400 taggcatat tgtgctgtac cca 1335<210>622<211>404<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>622Val Leu Val Thr Ser Thr Trp Gly Trp Thr Val His Gly Asp Gly Lys 151015 Lys Ile Glu Pro Gly Ala Val Val Ala Pro Lys Glu Arg Leu Ser Trp

20 25 30Gly Arg Thr Ile Gly Ile Gly Met Gln His Val Ile Ala Met Phe Gly

35 40 45Ala Thr Leu Leu Val Pro Thr Leu Thr Gly Phe Pro Val Asn Thr Thr

50 55 60Leu Leu Phe Ser Gly Leu Gly Thr Ile Leu Phe Leu Leu Ile Thr Arg 65 7075 80Asn Arg Leu Pro Ser Tyr Leu Gly Set Ser Phe Ala Phe Ile Ala Pro

85 90 95Leu Thr Ala Thr Gln Val His Gly Ile Gly Val Gln Ile Gly Gly Ile

100 105 110Leu Val Ala Gly Leu Val Leu Val Ala Ile Gly Phe Val Val Lys Ala

115 120 125Ala Gly Lys Arg Val Ile Asp Ala Val Met Pro Pro Ala Val Thr Gly

130 135 140Ala Ile Val Ala Leu Ile Gly Leu Asn Leu Ala Pro Thr Ala Ala Gly145 150 155 160Asn Phe Ser Ser Gln Pro Leu Val Ala Thr Ala Thr Leu Phe Ala Ile

165 170 175Leu Ile Ala Thr Val Ala Gly Arg Gly Met Ile Ala Arg Leu Gly Ile

180 185 190Leu Ile Gly Val Val Ile Gly Trp Val Phe Ala Ala Ile Thr Gly Asn

195 200 205Leu Ser Glu Gly Ala Ala Asp Thr Ile Arg Glu Ala Ala Trp Phe Gly

210 215 220Leu Pro Gln Phe His Lys Pro Glu Phe Gln Leu Ser Ala Ile Leu Val225 230 235 240Thr Leu Pro Val Ile Ile Val Leu Ile Ala Glu Asn Val Gly His Val

245 250 255Lys Ala Val Ser Glu Met Thr Gly Glu Asp Leu Asp Asp Leu Ala Gly

260 265 270Asp Ala Leu Ile Ala Asp Gly Phe Gly Thr Thr Leu Ala Gly Ala Phe

275 280 285Gly Gly Ser Gly Thr Thr Thr Tyr Ala Glu Asn Ile Gly Val Met Ala

290295 300Ala Thr Arg Val Tyr Ser Thr Ala Ala Tyr Trp Val Ala Ala Cys Thr305 310 315 320Ala Ile Ala Leu Ala Phe Ile Pro Lys Phe Gly Ala Leu Ile Phe Thr

325 330 335Ile Pro Ala Gly Val Leu Gly Gly Ala Cys Leu Val Leu Tyr Gly Leu

340 345 350Ile Gly Met Leu Gly Ile Arg Ile Trp Gln Asp Asn Lys Val Asn Phe

355 360 365Asn Asn Pro Val Asn Leu Thr Met Ala Ala Val Ala Leu Val Ala Gly

370375380 Ile Gly Asn Leu Thr Leu Thr Val Phe Gly Val Thr Leu Glu Gly Ile 385390395400 Ala Trp Ala Leu<210>623<211>2010<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1987)<223>RXN02372<400>623gacaatactg atggataaat ttcatatcga ggacgaaggg acaaccccga acgccgtgac 60aacatcaacc acaacccggg tgaaacatcc ggtagaccag gtg cca ccc gca ccc 115

Val Pro Pro Ala Pro

1 5aaa ctt gca gcc cta ggg ctc caa cac gtt ctt gct ttc tac gca gga 163Lys Leu Ala Ala Leu Gly Leu Gln His Val Leu Ala Phe Tyr Ala Gly

10 15 20gcc gtc att gtt ccg ctg ctg att gca cag tcg ctg aac ttg gac act 211Ala Val Ile Val Pro Leu Leu Ile Ala Gln Ser Leu Asn Leu Asp Thr

25 30 35gcg acc acc att cac ctg att aac gct gac ttg ttg aca tgt ggc atc 259Ala Thr Thr Ile His Leu Ile Asn Ala Asp Leu Leu Thr Cys Gly Ile

40 45 50gcc acg ttg att cag tct gtg ggc att ggt cgc cac att ggt gtg cgc 307Ala Thr Leu Ile Gln Ser Val Gly Ile Gly Arg His Ile Gly Val Arg

55 60 65cta ccg atc gtt caa ggt gtc acc act act gct gtt gct ccc atc atc 355Leu Pro Ile Val Gln Gly Val Thr Thr Thr Ala Val Ala Pro Ile Ile 70 75 80 85gcc att ggt ttg ggc gtt act gat ggt caa ggt ggc gtt gcg tcg ctg 403Ala Ile Gly Leu Gly Val Thr Asp Gly Gln Gly Gly Val Ala Ser Leu

90 95 100cct gcc att tac ggt gca gtc att gtc tcc ggc att ttc acg ttc ttt 451Pro Ala Ile Tyr Gly Ala Val Ile Val Ser Gly Ile Phe Thr Phe Phe

105 110 115gca gcg ccg gtg ttt gcg cgt ttc ctc aag ttc ttc cca cca gtt gtc 499Ala Ala Pro Val Phe Ala Arg Phe Leu Lys Phe Phe Pro Pro Val Val

120 125 130acc ggt act gtg ctg ttg gtt atg ggt gct tcc ctg ctg tcg gta tct 547Thr Gly Thr Val Leu Leu Val Met Gly Ala Ser Leu Leu Ser Val Ser

135 140 145gca aat gac ttt gtg aac tac gcc gat ggg gtg cct gct gcc cgc gat 595Ala Asn Asp Phe Val Asn Tyr Ala Asp Gly Val Pro Ala Ala Arg Asp150 155 160 165ctt gct tac ggt ttt ggc acc ttg gcg gtg atc att ttg gcg cag cgc 643Leu Ala Tyr Gly Phe Gly Thr Leu Ala Val Ile Ile Leu Ala Gln Arg

170 175 180ttc ttc cgt gga ttc atg ggc acc ttg gct gtg ttg atc ggc ctg gtt 691Phe Phe Arg Gly Phe Met Gly Thr Leu Ala Val Leu Ile Gly Leu Val

185 190 195ggt ggc acc gca gtt gct ctg atc ttg ggc gat gcc aac ttg gat gag 739Gly Gly Thr Ala Val Ala Leu Ile Leu Gly Asp Ala Asn Leu Asp Glu

200 205 210gtg gga aat gct gaa gcg ttc gac atc acc act ccg ttt tat ttt ggt 787Val Gly Asn Ala Glu Ala Phe Asp Ile Thr Thr Pro Phe Tyr Phe Gly

215 220 225gtt cca gaa ttt aac gct gtt gcc att ttc tcc atg att atc gtc atg 835Val Pro Glu Phe Asn Ala Val Ala Ile Phe Ser Met Ile Ile Val Met230 235 240 245atc atc acc atg gtg gag acc acc ggt gat gtg ttt gca acg ggg gaa 883Ile Ile Thr Met Val Glu Thr Thr Gly Asp Val Phe Ala Thr Gly Glu

250 255 260atc gtc ggc aag cga act cgc cgc agt gat gtc acc cgc gca ctg cgc 931Ile Val Gly Lys Arg Thr Arg Arg Ser Asp Val Thr Arg Ala Leu Arg

265 270 275gct gac ggc ctg tcc acc ctg atg ggt ggc gtc atg aac tcc ttc ccg 979Ala Asp Gly Leu Ser Thr Leu Met Gly Gly Val Met Asn Ser Phe Pro

280 285 290tac acg tgc ttc gcg caa aac gtt ggc ctg gtg cgc atc acg ggc gtg 1027Tyr Thr Cys Phe Ala Gln Asn Val Gly Leu Val Arg Ile Thr Gly Val

295 300 305aaa tct cgc tgg gtt gcg gca gct gct gcc ggc ttc atg atc atc ctc 1075Lys Ser Arg Trp Val Ala Ala Ala Ala Ala Gly Phe Met Ile Ile Leu310 315 320 325ggt gtg ctg ccc aag gct ggc gcg atc gtc gct tcc atc cct tcc cca 1123Gly Val Leu Pro Lys Ala Gly Ala Ile Val Ala Ser Ile Pro Ser Pro

330 335 340gtc ctc ggt ggc gca tcc ttg gca ctg ttc gcc aac gtt gca tgg gtg 1171Val Leu Gly Gly Ala Ser Leu Ala Leu Phe Ala Asn Val Ala Trp Val

345 350 355ggc atc cag acc atc gcc aag tct gac ctc gct gat agc cgc aac tcc 1219Gly Ile Gln Thr Ile Ala Lys Ser Asp Leu Ala Asp Ser Arg Asn Ser

360 365 370gtc atc gtg acc tcc gca ctt ggc cta gcc atg ctg gtg tcc ttc cgc 1267Val Ile Val Thr Ser Ala Leu Gly Leu Ala Met Leu Val Ser Phe Arg

375 380 385ccc gat gtt gct cag gcg ttc cct gag tgg gcg cgt atc ttc gtc tcc 1315Pro Asp Val Ala Gln Ala Phe Pro Glu Trp Ala Arg Ile Phe Val Ser390 395 400 405tcc ggc atg tcc gtc ggc gcg atc acc gcg atc ctg ctt aac ctg ctg 1363Ser Gly Met Ser Val Gly Ala Ile Thr Ala Ile Leu Leu Asn Leu Leu

410 415 420ttc ttc cac gtc gga cgc caa tcc ggt gga caa gtc gct acc tca aaa 1411Phe Phe His Val Gly Arg Gln Ser Gly Gly Gln Val Ala Thr Ser Lys

425 430 435tcc ggt gag cgc atc aat ttg gat gcg gtc aac aag atg gat cgc acc 1459Ser Gly Glu Arg Ile Asn Leu Asp Ala Val Asn Lys Met Asp Arg Thr

440 445 450gac ttc gta gaa acc ttc gca ccg ctg ttc aac agc aag acc tgg cct 1507Asp Phe Val Glu Thr Phe Ala Pro Leu Phe Asn Ser Lys Thr Trp Pro

455 460 465ttg gaa acc gca tgg gaa tcc cag cca ttc gcc aac gtc acg gaa ctg 1555Leu Glu Thr Ala Trp Glu Ser Gln Pro Phe Ala Asn Val Thr Glu Leu470 475 480 485cgc gaa gcc atc caa gtc gct gtg ctc acc gca ccg ttg tcc gac cgc 1603Arg Glu Ala Ile Gln Val Ala Val Leu Thr Ala Pro Leu Ser Asp Arg

490 495 500gaa gag ctc atc cac gac tac ccc gac atg gca cag ctc att ttg gcc 1651Glu Glu Leu Ile His Asp TyrPro Asp Met Ala Gln Leu Ile Leu Ala

505 510 515acc gaa gag gaa gcc gcc acc atc tct caa gac cgt ggt tcg atc ggt 1699Thr Glu Glu Glu Ala Ala Thr Ile Ser Gln Asp Arg Gly Ser Ile Gly

520 525 530ctt gat gat ctc gat gac gtg gat caa gaa aag ctc atc acc gtc acc 1747Leu Asp Asp Leu Asp Asp Val Asp Gln Glu Lys Leu Ile Thr Val Thr

535 540 545gag cag tac cgc gaa cgg ttc aac atg ccg tat gtt gcg tac ttc gac 1795Glu Gln Tyr Arg Glu Arg Phe Asn Met Pro Tyr Val Ala Tyr Phe Asp550 555 560 565acc atg gat tct gtg gat acc gtc gta gcc gcc ggc ttg cgc cgc ctc 1843Thr Met Asp Ser Val Asp Thr Val Val Ala Ala Gly Leu Arg Arg Leu

570 575 580gac aac tcc gac gag cag gag cac cgc caa gcg cta tcg gaa atc att 1891Asp Asn Ser Asp Glu Gln Glu His Arg Gln Ala Leu Ser Glu Ile Ile

585 590 595gag att gcc aat gac cgc ttc gat ata ttg ctt gcc gac gct aac cca 1939Glu Ile Ala Asn Asp Arg Phe Asp Ile Leu Leu Ala Asp Ala Asn Pro

600 605 610gcc cgt tca gct ttc gat cgc aag ttt acc gag act gac ttc ctc ggc 1987Ala Arg Ser Ala Phe Asp Arg Lys Phe Thr Glu Thr Asp Phe Leu Gly

615620625 taaaacacca aaaacaaatt aag 2010<210>624<211>629<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>624Val Pro Pro Ala Pro Lys Leu Ala Ala Leu Gly Leu Gln His Val Leu 151015 Ala Phe Tyr Ala Gly Ala Val Ile Val Pro Leu Leu Ile Ala Gln Ser

20 25 30Leu Asn Leu Asp Thr Ala Thr Thr Ile His LeuIle Asn Ala Asp Leu

35 40 45Leu Thr Cys Gly Ile Ala Thr Leu Ile Gln Ser Val Gly Ile Gly Arg

50 55 60His Ile Gly Val Arg Leu Pro Ile Val Gln Gly Val Thr Thr Thr Ala 65 70 75 80Val Ala Pro Ile Ile Ala Ile Gly Leu Gly Val Thr Asp Gly Gln Gly

85 90 95Gly Val Ala Ser Leu Pro Ala Ile Tyr Gly Ala Val Ile Val Ser Gly

100 105 110Ile Phe Thr Phe Phe Ala Ala Pro Val Phe Ala Arg Phe Leu Lys Phe

115 120 125Phe Pro Pro Val Val Thr Gly Thr Val Leu Leu Val Met Gly Ala Ser

130 135 140Leu Leu Ser Val Ser Ala Asn Asp Phe Val Asn Tyr Ala Asp Gly Val145 150 155 160Pro Ala Ala Arg Asp Leu Ala Tyr Gly Phe Gly Thr Leu Ala Val Ile

165 170 175Ile Leu Ala Gln Arg Phe Phe Arg Gly Phe Met Gly Thr Leu Ala Val

180 185 190Leu Ile Gly Leu Val Gly Gly Thr Ala Val Ala Leu Ile Leu Gly Asp

195 200 205Ala Asn Leu Asp Glu Val Gly Asn Ala Glu Ala Phe Asp Ile Thr Thr

210 215 220Pro Phe Tyr Phe Gly Val Pro Glu Phe Asn Ala Val Ala Ile Phe Ser225 230 235 240Met Ile Ile Val Met Ile Ile Thr Met Val Glu Thr Thr Gly Asp Val

245 250 255Phe Ala Thr Gly Glu Ile Val Gly Lys ArgThr Arg Arg Ser Asp Val

260 265 270Thr Arg Ala Leu Arg Ala Asp Gly Leu Ser Thr Leu Met Gly Gly Val

275 280 285Met Asn Ser Phe Pro Tyr Thr Cys Phe Ala Gln Asn Val Gly Leu Val

290 295 300Arg Ile Thr Gly Val Lys Ser Arg Trp Val Ala Ala Ala Ala Ala Gly305 310 315 320Phe Met Ile Ile Leu Gly Val Leu Pro Lys Ala Gly Ala Ile Val Ala

325 330 335Ser Ile Pro Ser Pro Val Leu Gly Gly Ala Ser Leu Ala Leu Phe Ala

340 345 350Asn Val Ala Trp Val Gly Ile Gln Thr Ile Ala Lys Ser Asp Leu Ala

355 360 365Asp Ser Arg Asn Ser Val Ile Val Thr Ser Ala Leu Gly Leu Ala Met

370 375 380Leu Val Ser Phe Arg Pro Asp Val Ala Gln Ala Phe Pro Glu Trp Ala385 390 395 400Arg Ile Phe Val Ser Ser Gly Met Ser Val Gly Ala Ile Thr Ala Ile

405 410 415Leu Leu Asn Leu Leu Phe Phe His Val Gly Arg Gln Ser Gly Gly Gln

420 425 430Val Ala Thr Ser Lys Ser Gly Glu Arg Ile Asn Leu Asp Ala Val Asn

435 440 445Lys Met Asp Arg Thr Asp Phe Val Glu Thr Phe Ala Pro Leu Phe Asn

450 455 460Ser Lys Thr Trp Pro Leu Glu Thr Ala Trp Glu Ser Gln Pro Phe Ala465 470 475 480Asn Val Thr Glu Leu Arg Glu Ala Ile GlnVal Ala Val Leu Thr Ala

485 490 495Pro Leu Ser Asp Arg Glu Glu Leu Ile His Asp Tyr Pro Asp Met Ala

500 505 510Gln Leu Ile Leu Ala Thr Glu Glu Glu Ala Ala Thr Ile Ser Gln Asp

515 520 525Arg Gly Ser Ile Gly Leu Asp Asp Leu Asp Asp Val Asp Gln Glu Lys

530 535 540Leu Ile Thr Val Thr Glu Gln Tyr Arg Glu Arg Phe Asn Met Pro Tyr545 550 555 560Val Ala Tyr Phe Asp Thr Met Asp Ser Val Asp Thr Val Val Ala Ala

565 570 575Gly Leu Arg Arg Leu Asp Asn Ser Asp Glu Gln Glu His Arg Gln Ala

580 585 590Leu Ser Glu Ile Ile Glu Ile Ala Asn Asp Arg Phe Asp Ile Leu Leu

595 600 605Ala Asp Ala Asn Pro Ala Arg Ser Ala Phe Asp Arg Lys Phe Thr Glu

610615620 Thr Asp Phe Leu Gly625<210>625<211>578<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (555)<223>FRXA02372<400>625gat gcg gtc aac aag atg gat cgc acc gac ttc gta gaa acc ttc gca 48Asp Ala Val Asn Lys Met Asp Arg Thr Asp Phe Val Glu Thr Phe Ala 151015 ccg ctg ttc aac agc aag acc tgg cct ttg gaa acc gca tgg gaa tcc 96Pro Leu Phe Asn Ser Lys Thr Trp Pro Leu Glu Thr Ala Trp Glu Ser

20 25 30cag cca ttc gcc aac gtc acg gaa ctg cgc gaa gcc atc caa gtc gct 144Gln Pro Phe Ala Asn Val Thr Glu Leu Arg Glu Ala Ile Gln Val Ala

3540 45gtg ctc acc gca ccg ttg tcc gac cgc gaa gag ctc atc cac gac tac 192Val Leu Thr Ala Pro Leu Ser Asp Arg Glu Glu Leu Ile His Asp Tyr

50 55 60ccc gac atg gca cag ctc att ttg gcc acc gaa gag gaa gcc gcc acc 240Pro Asp Met Ala Gln Leu Ile Leu Ala Thr Glu Glu Glu Ala Ala Thr 65 70 75 80atc tct caa gac cgt ggt tcg atc ggt ctt gat gat ctc gat gac gtg 288Ile Ser Gln Asp Arg Gly Ser Ile Gly Leu Asp Asp Leu Asp Asp Val

85 90 95gat caa gaa aag ctc atc acc gtc acc gag cag tac cgc gaa cgg ttc 336Asp Gln Glu Lys Leu Ile Thr Val Thr Glu Gln Tyr Arg Glu Arg Phe

100 105 110aac atg ccg tat gtt gcg tac ttc gac acc atg gat tct gtg gat acc 384Asn Met Pro Tyr Val Ala Tyr Phe Asp Thr Met Asp Ser Val Asp Thr

115 120 125gtc gta gcc gcc ggc ttg cgc cgc ctc gac aac tcc gac gag cag gag 432Val Val Ala Ala Gly Leu Arg Arg Leu Asp Asn Ser Asp Glu Gln Glu

130 135 140cac cgc caa gcg cta tcg gaa atc att gag att gcc aat gac cgc ttc 480His Arg Gln Ala Leu Ser Glu Ile Ile Glu Ile Ala Asn Asp Arg Phe145 150 155 160gat ata ttg ctt gcc gac gct aac cca gcc cgt tca gct ttc gat cgc 528Asp Ile Leu Leu Ala Asp Ala Asn Pro Ala Arg Ser Ala Phe Asp Arg

165 170 175aag ttt acc gag act gac ttc ctc ggc taaaacacca aaaacaaatt 575Lys Phe Thr Glu Thr Asp Phe Leu Gly

180185 aag 578<210>626<211>185<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>626Asp Ala Val Asn Lys Met Asp Arg Thr Asp Phe Val Glu Thr Phe Ala 151015 Pro Leu Phe Asn Ser Lys Thr Trp Pro Leu Glu Thr Ala Trp Glu Ser

20 25 30Gln Pro Phe Ala Asn Val Thr Glu Leu Arg Glu Ala Ile Gln Val Ala

35 40 45Val Leu Thr Ala Pro Leu Ser Asp Arg Glu Glu Leu Ile His Asp Tyr

50 55 60Pro Asp Met Ala Gln Leu Ile Leu Ala Thr Glu Glu Glu Ala Ala Thr 65 70 75 80Ile Ser Gln Asp Arg Gly Ser Ile Gly Leu Asp Asp Leu Asp Asp Val

85 90 95Asp Gln Glu Lys Leu Ile Thr Val Thr Glu Gln Tyr Arg Glu Arg Phe

100 105 110Asn Met Pro Tyr Val Ala Tyr Phe Asp Thr Met Asp Ser Val Asp Thr

115 120 125Val Val Ala Ala Gly Leu Arg Arg Leu Asp Asn Ser Asp Glu Gln Glu

130 135 140His Arg Gln Ala Leu Ser Glu Ile Ile Glu Ile Ala Asn Asp Arg Phe145 150 155 160Asp Ile Leu Leu Ala Asp Ala Asn Pro Ala Arg Ser Ala Phe Asp Arg

165 170 175Lys Phe Thr Glu Thr Asp Phe Leu Gly

180185<210>627<211>1314<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1291)<223>FRXA02377<400>627gacaatactg atggataaat ttcatatcga ggacgaaggg acaaccccga acgccgtgac 60aacatcaacc acaacccggg tgaaacatcc ggtagaccag gtg cca ccc gca ccc 115

Val Pro Pro Ala Pro

1 5aaa ctt gca gcc cta ggg ctc caa cac gtt ctt gct ttc tac gca gga 163Lys Leu Ala Ala Leu Gly Leu Gln His Val Leu Ala Phe Tyr Ala Gly

10 15 20gcc gtc att gtt ccg ctg ctg att gca cag tcg ctg aac ttg gac act 211Ala Val Ile Val Pro Leu Leu Ile Ala Gln Ser Leu Asn Leu Asp Thr

25 30 35gcg acc acc att cac ctg att aac gct gac ttg ttg aca tgt ggc atc 259Ala Thr Thr Ile His Leu Ile Asn Ala Asp Leu Leu Thr Cys Gly Ile

40 45 50gcc acg ttg att cag tct gtg ggc att ggt cgc cac att ggt gtg cgc 307Ala Thr Leu Ile Gln Ser Val Gly Ile Gly Arg His Ile Gly Val Arg

55 60 65cta ccg atc gtt caa ggt gtc acc act act gct gtt gct ccc atc atc 355Leu Pro Ile Val Gln Gly Val Thr Thr Thr Ala Val Ala Pro Ile Ile 70 75 80 85gcc att ggt ttg ggc gtt act gat ggt caa ggt ggc gtt gcg tcg ctg 403Ala Ile Gly Leu Gly Val Thr Asp Gly Gln Gly Gly Val Ala Ser Leu

90 95 100cct gcc att tac ggt gca gte att gtc tcc ggc att ttc acg ttc ttt 451Pro Ala Ile Tyr Gly Ala Val Ile Val Ser Gly Ile Phe Thr Phe Phe

105 110 115gca gcg ccg gtg ttt gcg cgt ttc ctc aag ttc ttc cca cca gtt gtc 499Ala Ala Pro Val Phe Ala Arg Phe Leu Lys Phe Phe Pro Pro Val Val

120 125 130acc ggt act gtg ctg ttg gtt atg ggt gct tcc ctg ctg tcg gta tct 547Thr Gly Thr Val Leu Leu Val Met Gly Ala Ser Leu Leu Ser Val Ser

135 140 145gca aat gac ttt gtg aac tac gcc gat ggg gtg cct gct gcc cgc gat 595Ala Asn Asp Phe Val Asn Tyr Ala Asp Gly Val Pro Ala Ala Arg Asp150 155 160 165ctt gct tac ggt ttt ggc acc ttg gcg gtg atc att ttg gcg cag cgc 643Leu Ala Tyr Gly Phe Gly Thr Leu Ala Val Ile Ile Leu Ala Gln Arg

170 175 180ttc ttc cgt gga ttc atg ggc acc ttg gct gtg ttg atc ggc ctg gtt 691Phe Phe Arg Gly Phe Met Gly Thr Leu Ala Val Leu Ile Gly Leu Val

185 190 195ggt ggc acc gca gtt gct ctg atc ttg ggc gat gcc aac ttg gat gag 739Gly Gly Thr Ala Val Ala Leu Ile Leu Gly Asp Ala Asn Leu Asp Glu

200 205 210gtg gga aat gct gaa gcg ttc gac atc acc act ccg ttt tat ttt ggt 787Val Gly Asn Ala Glu Ala Phe Asp Ile Thr Thr Pro Phe Tyr Phe Gly

215 220 225gtt cca gaa ttt aac gct gtt gcc att ttc tcc atg att atc gtc atg 835Val Pro Glu Phe Asn Ala Val Ala Ile Phe Ser Met Ile Ile Val Met230 235 240 245atc atc acc atg gtg gag acc acc ggt gat gtg ttt gca acg ggg gaa 883Ile Ile Thr Met Val Glu Thr Thr Gly Asp Val Phe Ala Thr Gly Glu

250 255 260atc gtc ggc aag cga act cgc cgc agt gat gtc acc cgc gca ctg cgc 931Ile Val Gly Lys Arg Thr Arg Arg Ser Asp Val Thr Arg Ala Leu Arg

265 270 275gct gac ggc ctg tcc acc ctg atg ggt ggc gtc atg aac tcc ttc ccg 979Ala Asp Gly Leu Ser Thr Leu Met Gly Gly Val Met Asn Ser Phe Pro

280 285 290tac acg tgc ttc gcg caa aac gtt ggc ctg gtg cgc atc acg ggc gtg 1027Tyr Thr Cys Phe Ala GlnAsn Val Gly Leu Val Arg Ile Thr Gly Val

295 300 305aaa tct cgc tgg gtt gcg gca gct gct gcc ggc ttc atg atc atc ctc 1075Lys Ser Arg Trp Val Ala Ala Ala Ala Ala Gly Phe Met Ile Ile Leu310 315 320 325ggt gtg ctg ccc aag gct ggc gcg atc gtc gct tcc atc cct tcc cca 1123Gly Val Leu Pro Lys Ala Gly Ala Ile Val Ala Ser Ile Pro Ser Pro

330 335 340gtc ctc ggt ggc gca tcc ttg gca ctg ttc gcc aac gtt gca tgg gtg 1171Val Leu Gly Gly Ala Ser Leu Ala Leu Phe Ala Asn Val Ala Trp Val

345 350 355ggc atc cag acc arc gcc aag tct gac ctc gct gat agc cgc aac tcc 1219Gly Ile Gln Thr Ile Ala Lys Ser Asp Leu Ala Asp Ser Arg Asn Ser

360 365 370gtc atc gtg acc tcc gca ctt ggc cta gcc atg ctg gtg tcc ttc cgc 1267Val Ile Val Thr Ser Ala Leu Gly Leu Ala Met Leu Val Ser Phe Arg

375380385 ccc gat gtt gct caa ggc gtt ccc tgagtgggcg cgtatcttcg tct 1314 35 1314Pro Asp Val Ala Gln Gly Val Pro 390395<210>628<211>397<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>628<628Val Pro Pro Ala Pro Lys Leu Ala Ala Leu Gly Leu Gln His Val Leu 151015 Ala Phe Tyr Ala Gly Ala Val Ile Val Pro Leu Leu Ile Ala Gln Ser

20 25 30Leu Asn Leu Asp Thr Ala Thr Thr Ile His Leu Ile Asn Ala Asp Leu

35 40 45Leu Thr Cys Gly Ile Ala Thr Leu Ile Gln Ser Val Gly Ile Gly Arg

50 55 60His Ile Gly Val Arg Leu Pro Ile Val Gln Gly Val Thr Thr Thr Ala 65 7075 80Val Ala Pro Ile Ile Ala Ile Gly Leu Gly Val Thr Asp Gly Gln Gly

85 90 95Gly Val Ala Ser Leu Pro Ala Ile Tyr Gly Ala Val Ile Val Ser Gly

100 105 110Ile Phe Thr Phe Phe Ala Ala Pro Val Phe Ala Arg Phe Leu Lys Phe

115 120 125Phe Pro Pro Val Val Thr Gly Thr Val Leu Leu Val Met Gly Ala Ser

130 135 140Leu Leu Ser Val Ser Ala Asn Asp Phe Val Asn Tyr Ala Asp Gly Val145 150 155 160Pro Ala Ala Arg Asp Leu Ala Tyr Gly Phe Gly Thr Leu Ala Val Ile

165 170 175Ile Leu Ala Gln Arg Phe Phe Arg Gly Phe Met Gly Thr Leu Ala Val

180 185 190Leu Ile Gly Leu Val Gly Gly Thr Ala Val Ala Leu Ile Leu Gly Asp

195 200 205Ala Asn Leu Asp Glu Val Gly Asn Ala Glu Ala Phe Asp Ile Thr Thr

210 215 220Pro Phe Tyr Phe Gly Val Pro Glu Phe Asn Ala Val Ala Ile Phe Ser225 230 235 240Met Ile Ile Val Met Ile Ile Thr Met Val Glu Thr Thr Gly Asp Val

245 250 255Phe Ala Thr Gly Glu Ile Val Gly Lys Arg Thr Arg Arg Ser Asp Val

260 265 270Thr Arg Ala Leu Arg Ala Asp Gly Leu Ser Thr Leu Met Gly Gly Val

275 280 285Met Asn Ser Phe Pro Tyr Thr Cys Phe Ala Gln Asn Val Gly Leu Val

290295 300Arg Ile Thr Gly Val Lys Ser Arg Trp Val Ala Ala Ala Ala Ala Gly305 310 315 320Phe Met Ile Ile Leu Gly Val Leu Pro Lys Ala Gly Ala Ile Val Ala

325 330 335Ser Ile Pro Ser Pro Val Leu Gly Gly Ala Ser Leu Ala Leu Phe Ala

340 345 350Asn Val Ala Trp Val Gly Ile Gln Thr Ile Ala Lys Ser Asp Leu Ala

355 360 365Asp Ser Arg Asn Ser Val Ile Val Thr Ser Ala Leu Gly Leu Ala Met

370375380 Leu Val Ser Phe Arg Pro Asp Val Ala Gln Gly Val Pro 385390395<210>629<211>1512<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1489)<223>RXA02676<400>629aaccattggg tattaagaaa tttgtggctt agatctcaat ttctgtatag tttgatcata 60ctaattcatc cacttccaaa ttttcacgaa ggatcacccc atg gac acc tgg gaa 115

Met Asp Thr Trp Glu

1 5caa acc ctt gga aca ggg cca ctg cta ggc att gca gcc ggc gcc att 163Gln Thr Leu Gly Thr Gly Pro Leu Leu Gly Ile Ala Ala Gly Ala Ile

10 15 20gcc ctc atc ttg gtt ctc gtc atc gtt ttt aaa ctc cat gct ttt ctc 211Ala Leu Ile Leu Val Leu Val Ile Val Phe Lys Leu His Ala Phe Leu

25 30 35acc cta ata ctg gtt tca att gtt acc gca ctt gct gcc ggc att ccc 259Thr Leu Ile Leu Val Ser Ile Val Thr Ala Leu Ala Ala Gly Ile Pro

40 45 50gtc acc gca gta gtg gac act ctc ctt gac ggt ttt ggt aaa aca ctc 307Val Thr Ala Val Val Asp Thr Leu Leu Asp Gly Phe Gly Lys Thr Leu

55 60 65gcc tcg gtc gcc cta ttg gta ggc ctg ggt gcc atg ctt ggt cga ttg 355Ala Ser Val Ala Leu Leu Val Gly Leu Gly Ala Met Leu Gly Arg Leu 70 75 80 85gtt gaa aca tcc ggt ggc gca aaa tct cta gcc gac act atg gtg cga 403Val Glu Thr Ser Gly Gly Ala Lys Ser Leu Ala Asp Thr Met Val Arg

90 95 100atc ttc ggt gaa aaa cga gca gct ttc gca ctc ggt gtc gca tcg ctg 451Ile Phe Gly Glu Lys Arg Ala Ala Phe Ala Leu Gly Val Ala Ser Leu

105 110 115atc atg gga ttc cct atc ttc ttc gat gct ggc ctc gtg gtc atg ctc 499Ile Met Gly Phe Pro Ile Phe Phe Asp Ala Gly Leu Val Val Met Leu

120 125 130cca gtg atc ttc gca gta gct cga cgc ctc aac ggc tcc gtc ctt act 547Pro Val Ile Phe Ala Val Ala Arg Arg Leu Asn Gly Ser Val Leu Thr

135 140 145ttt ggt atc cct gca gct ggc gcc ttc tct gtc atg cac gtg ttc gtc 595Phe Gly Ile Pro Ala Ala Gly Ala Phe Ser Val Met His Val Phe Val150 155 160 165cca cct cac cca ggc cca att gca gcc tct gaa ttc ttc ggc gca caa 643Pro Pro His Pro Gly Pro Ile Ala Ala Ser Glu Phe Phe Gly Ala Gln

170 175 180gtt gga tac gta cta atc gct ggc atc atc gtt gca cta ccc acc tgg 691Val Gly Tyr Val Leu Ile Ala Gly Ile Ile Val Ala Leu Pro Thr Trp

185 190 195tat tta acc ggt tac ctg cta ggt aag ttc tta ggc cga aag ttc ccc 739Tyr Leu Thr Gly Tyr Leu Leu Gly Lys Phe Leu Gly Arg Lys Phe Pro

200 205 210ctt ccc gta ccc gat cta ctc agt ggt gga gca cag gaa gat gat cag 787Leu Pro Val Pro Asp Leu Leu Ser Gly Gly Ala Gln Glu Asp Asp Gln

215 220 225cct cag aac cca gct aac gca gtg tcg atc att gtc att ttg ctc att 835Pro Gln Asn Pro Ala Asn Ala Val Ser Ile Ile Val Ile Leu Leu Ile230 235 240 245cct atg ctc ctt att ttt ggc aat acc gga aca tca atg gca gtt tcc 883Pro Met Leu Leu Ile Phe Gly Asn Thr Gly Thr Ser Met Ala Val Ser

250 255 260gcc ggc ctc cta gat gca gaa tcc acc atg gtg aaa att cta gga ttc 931Ala Gly Leu Leu Asp Ala Glu Ser Thr Met Val Lys Ile Leu Gly Phe

265 270 275ctc ggc gaa aca cca gtg gca ctg ctc att acc ttg atc att gcc ctg 979Leu Gly Glu Thr Pro Val Ala Leu Leu Ile Thr Leu Ile Ile Ala Leu

280 285 290ttc ttc cta ggc aac cga cgt ggc att aat ggt tct gct cta gag aaa 1027Phe Phe Leu Gly Asn Arg Arg Gly Ile Asn Gly Ser Ala Leu Glu Lys

295 300 305acc atc gaa ggc gca ctc ggc cca atc tgt tca gtc gta tta atc act 1075Thr Ile Glu Gly Ala Leu Gly Pro Ile Cys Ser Val Val Leu Ile Thr310 315 320 325ggc gcc ggt ggc atg ttc ggt gga gtg cta cgc acg tct gga att gga 1123Gly Ala Gly Gly Met Phe Gly Gly Val Leu Arg Thr Ser Gly Ile Gly

330 335 340gga gcg ctt gca gac tcc atg gca gat cta gga ctt cca gtt atc gca 1171Gly Ala Leu Ala Asp Ser Met Ala Asp Leu Gly Leu Pro Val Ile Ala

345 350 355ggt tgt ttc atc gtg gca gcc gtc ctt cgt gtc gcg cag ggt tct gcc 1219Gly Cys Phe Ile Val Ala Ala Val Leu Arg Val Ala Gln Gly Ser Ala

360 365 370acc gtt gcg cta acc acc gcc gca gca ctc atg gca cct gct gtt gcc 1267Thr Val Ala Leu Thr Thr Ala Ala Ala Leu Met Ala Pro Ala Val Ala

375 380 385gct gct gac ttt aac gaa ttc cag ctt gct gcc atc gtt att tcc act 1315Ala Ala Asp Phe Asn Glu Phe Gln Leu Ala Ala Ile Val Ile Ser Thr390 395 400 405gcc gct ggt tct gtt att gcc agc cac gtc aac gac tcc gga ttc tgg 1363Ala Ala Gly Ser Val Ile Ala Ser His Val Asn Asp Ser Gly Phe Trp

410 415 420ctc gtt ggt cga ctc atg aac gcc gac gta ccc acc acg cta aaa act 1411Leu Val Gly Arg Leu Met Asn Ala Asp Val Pro Thr Thr Leu Lys Thr

425 430 435tgg acc gta aac caa acc tgc att gcg att gtg gga ttt gtg atg gcc 1459Trp Thr Val Asn Gln Thr Cys Ile Ala Ile Val Gly Phe Val Met Ala

440 445 450tat gca atg ttc gga ttg gca tcg ctt gca tagtccgctg accccattga 1509Tyr Ala Met Phe Gly Leu Ala Ser Leu Ala

455460 ttc1512<210>630<211>463<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>630Met Asp Thr Trp Glu Gln Thr Leu Gly Thr Gly Pro Leu Leu Gly Ile 151015 Ala Ala Gly Ala Ile Ala Leu Ile Leu Val Leu Val Ile Val Phe Lys

20 25 30Leu His Ala Phe Leu Thr Leu Ile Leu Val Ser Ile Val Thr Ala Leu

35 40 45Ala Ala Gly Ile Pro Val Thr Ala Val Val Asp Thr Leu Leu Asp Gly

50 55 60Phe Gly Lys Thr Leu Ala Ser Val Ala Leu Leu Val Gly Leu Gly Ala 65 70 75 80Met Leu Gly Arg Leu Val Glu Thr Ser Gly Gly Ala Lys Ser Leu Ala

85 90 95Asp Thr Met Val Arg Ile Phe Gly Glu Lys Arg Ala Ala Phe Ala Leu

100 105 110Gly Val Ala Ser Leu Ile Met Gly Phe Pro Ile Phe Phe Asp Ala Gly

115 120 125Leu Val Val Met Leu Pro Val Ile Phe Ala Val Ala Arg Arg Leu Asn

130 135 140Gly Ser Val Leu Thr Phe Gly Ile Pro Ala Ala Gly Ala Phe Ser Val145 150 155 160Met His Val Phe Val Pro Pro His Pro Gly Pro Ile Ala Ala Ser Glu

165 170 175Phe Phe Gly Ala Gln Val Gly Tyr Val Leu Ile Ala Gly Ile Ile Val

180 185 190Ala Leu Pro Thr Trp Tyr Leu Thr Gly Tyr Leu Leu Gly Lys Phe Leu

195 200 205Gly Arg Lys Phe Pro Leu Pro Val Pro Asp Leu Leu Ser Gly Gly Ala

210 215 220Gln Glu Asp Asp Gln Pro Gln Asn Pro Ala Asn Ala Val Ser Ile Ile225 230 235 240Val Ile Leu Leu Ile Pro Met Leu Leu Ile Phe Gly Asn Thr Gly Thr

245 250 255Ser Met Ala Val Ser Ala Gly Leu Leu Asp Ala Glu Ser Thr Met Val

260 265 270Lys Ile Leu Gly Phe Leu Gly Glu Thr Pro Val Ala Leu Leu Ile Thr

275 280 285Leu Ile Ile Ala Leu Phe Phe Leu Gly Asn Arg Arg Gly Ile Asn Gly

290 295 300Ser Ala Leu Glu Lys Thr Ile Glu Gly Ala Leu Gly Pro Ile Cys Ser305 310 315 320Val Val Leu Ile Thr Gly Ala Gly Gly Met Phe Gly Gly Val Leu Arg

325 330 335Thr Ser Gly Ile Gly Gly Ala Leu Ala Asp Ser Met Ala Asp Leu Gly

340 345 350Leu Pro Val Ile Ala Gly Cys Phe Ile Val Ala Ala Val Leu Arg Val

355 360 365Ala Gln Gly Ser Ala Thr Val Ala Leu Thr Thr Ala Ala Ala Leu Met

370 375 380Ala Pro Ala Val Ala Ala Ala Asp Phe Asn Glu Phe Gln Leu Ala Ala385 390 395 400Ile Val Ile Ser Thr Ala Ala Gly Ser Val Ile Ala Ser His Val Asn

405 410 415Asp Ser Gly Phe Trp Leu Val Gly Arg Leu Met Asn Ala Asp Val Pro

420 425 430Thr Thr Leu Lys Thr Trp Thr Val Asn Gln Thr Cys Ile Ala Ile Val

435 440 445Gly Phe Val Met Ala Tyr Ala Met Phe Gly Leu Ala Ser Leu Ala

450455460<210>631<211>1608<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1585)<223>RXN00432<400>631agctaatctg ccttgcttta cacctccggg ctataacaat ccagtgccag tggctaggga 60tttactaaaa atcgggtaac acgcgcgtag tatttttcgc atg gaa tta ttg gag 115

Met Glu Leu Leu Glu

1 5acc ttc atc act gat gtc att aat gac aat ttg tgg atg atc ttg ccc 163Thr Phe Ile Thr Asp Val Ile Asn Asp Asn Leu Trp Met Ile Leu Pro

10 15 20ttc ttg ctc gtt gct gct ggc ctc tat ttc ggt ggg cgt acg ttg ctg 211Phe Leu Leu Val Ala Ala Gly Leu Tyr Phe Gly Gly Arg Thr Leu Leu

25 30 35gtt cag att cgg atg att ccg gag atg ttc aaa gcg gtc gtc gag aag 259Val Gln Ile Arg Met Ile Pro Glu Met Phe Lys Ala Val Val Glu Lys

40 45 50cct gcg aag gat ggg gag ttc gcg gac aag cag gac att tcg gct ttt 307Pro Ala Lys Asp Gly Glu Phe Ala Asp Lys Gln Asp Ile Ser Ala Phe

55 60 65aag gcg ttc acg att tct gcg gcg tcg cga gtt ggt acg gcg aat gtt 355Lys Ala Phe Thr Ile Ser Ala Ala Ser Arg Val Gly Thr Ala Asn Val 70 75 80 85gcg ggt gtt gcg ctg gcg atc act ctg ggt gga ccg ggt gca gtg ttc 403Ala Gly Val Ala Leu Ala Ile Thr Leu Gly Gly Pro Gly Ala Val Phe

90 95 100tgg atg tgg atc att gcg ctg gtt ggc ggt gcg aca tcg ttc att gag 451Trp Met Trp Ile Ile Ala Leu Val Gly Gly Ala Thr Ser Phe Ile Glu

105 110 115tcg act ctt gga cag ttg tgg aag gtg aag gac ggc gac agc tat cgc 499Ser Thr Leu Gly Gln Leu Trp Lys Val Lys Asp Gly Asp Ser Tyr Arg

120 125 130ggt ggc cct gcg tac tac atg acg ctt ggt ttg aat gct cgg tgg ctt 547Gly Gly Pro Ala Tyr Tyr Met Thr Leu Gly Leu Asn Ala Arg Trp Leu

135 140 145gcg gtt gtt ttc ggt gtc gcc atc acg ttg acc ttt ggt ttt gtg tac 595Ala Val Val Phe Gly Val Ala Ile Thr Leu Thr Phe Gly Phe Val Tyr150 155 160 165aac gct ttg cag tcc aac gcg gtt gtt gag gcg att acg gta tca ctc 643Asn Ala Leu Gln Ser Asn Ala Val Val Glu Ala Ile Thr Val Ser Leu

170 175 180ggc acc cct tct acc act gca aag gct ttt gtt ggc ttg ggc atg gct 691Gly Thr Pro Ser Thr Thr Ala Lys Ala Phe Val Gly Leu Gly Met Ala

185 190 195gga ttg tct gcg ctg gtt att ttt ggc ggc gtg cag cgt atc gca aac 739Gly Leu Ser Ala Leu Val Ile Phe Gly Gly Val Gln Arg Ile Ala Asn

200 205 210gtg acg cag tgg atg gtt ccg ttc atg gcg ggt gcg tac atc att gtg 787Val Thr Gln Trp Met Val Pro Phe Met Ala Gly Ala Tyr Ile Ile Val

215 220 225ggt gtg gtg gtg att gtg att aac att cag cag gtt ccg acc atg atc 835Gly Val Val Val Ile Val Ile Asn Ile Gln Gln Val Pro Thr Met Ile230 235 240 245aac gac atc att gct ggt gct ttt ggt ttc cgt ccg gtt gct act gcg 883Asn Asp Ile Ile Ala Gly Ala Phe Gly Phe Arg Pro Val Ala Thr Ala

250 255 260tcg gtg tgg ggc gcg ttc tgg ttg gcg ttt atg aac ggt atg cgc cgt 931Ser Val Trp Gly Ala Phe Trp Leu Ala Phe Met Asn Gly Met Arg Arg

265 270 275gga ctg ttc tcc aat gag gct ggt gag ggt tct gtc ccg aac gct gct 979Gly Leu Phe Ser Asn Glu Ala Gly Glu Gly Ser Val Pro Asn Ala Ala

280 285 290gct acc gcg act gtg tct cac cct gtg aag cag ggt ttg gtt cag act1027Ala Thr Ala Thr Val Ser His Pro Val Lys Gln Gly Leu Val Gln Thr

295 300 305ctg ggc gta tat ttc gac acc ctg ctc gtt tgt agc att acc gct ttt 1075Leu Gly Val Tyr Phe Asp Thr Leu Leu Val Cys Ser Ile Thr Ala Phe310 315 320 325gtc atc ctg ctg tct gga gtg gag tac gcg acc ggc gat att cag tct 1123Val Ile Leu Leu Ser Gly Val Glu Tyr Ala Thr Gly Asp Ile Gln Ser

330 335 340tct tct ttg act cag tcc gcg ctg gct agc gtt gtt ggt ggt tgg gga 1171Ser Ser Leu Thr Gln Ser Ala Leu Ala Ser Val Val Gly Gly Trp Gly

345 350 355acc cac ttc att acc gta gtg atg ttc ttc ctg gcg ttt tct tcc gtg 1219Thr His Phe Ile Thr Val Val Met Phe Phe Leu Ala Phe Ser Ser Val

360 365 370ctg ggt aac tac tac ttg gca cag gcg aat att cag tac ttc acc gat 1267Leu Gly Asn Tyr Tyr Leu Ala Gln Ala Asn Ile Gln Tyr Phe Thr Asp

375 380 385tcg aag act gtc atg act gtt ttc cga ctc ttg gtg ctg ctc agc gtg 1315Ser Lys Thr Val Met Thr Val Phe Arg Leu Leu Val Leu Leu Ser Val390 395 400 405ttc tct ggc gcg gtt gct tcg gtg ccg ttg atc tgg gct ttg ggt gat 1363Phe Ser Gly Ala Val Ala Ser Val Pro Leu Ile Trp Ala Leu Gly Asp

410 415 420act ttc gct ggc atc atg gtg ctc att aac ctg gcg gcg atc att ccg 1411Thr Phe Ala Gly Ile Met Val Leu Ile Asn Leu Ala Ala Ile Ile Pro

425 430 435ctg ggt ggc gtt gca gtg aag ttg ctt aag aat tac acc att cag aag 1459Leu Gly Gly Val Ala Val Lys Leu Leu Lys Asn Tyr Thr Ile Gln Lys

440 445 450aag gct ggt ctg gat cct gtg ttc cac cgc gac atg atg cca gag gtt 1507Lys Ala Gly Leu Asp Pro Val Phe His Arg Asp Met Met Pro Glu Val

455 460 465cgt aat att gcg tgc tgg aac ggc aaa gat gca gct aca tcc aac tat 1555Arg Asn Ile Ala Cys Trp Asn Gly Lys Asp Ala Ala Thr Ser Asn Tyr470 475 480 485cac gaa gcg atg gaa gtg atc aag aag agc tagtcatcga aggaacagtg 1605His Glu Ala Met Glu Val Ile Lys Lys Ser

490495 gta1608<210>632<211>495<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>632Met Glu Leu Leu Glu Thr Phe Ile Thr Asp Val Ile Asn Asp Asn Leu 151015 Trp Met Ile Leu Pro Phe Leu Leu Val Ala Ala Gly Leu Tyr Phe Gly

20 25 30Gly Arg Thr Leu Leu Val Gln Ile Arg Met Ile Pro Glu Met Phe Lys

35 40 45Ala Val Val Glu Lys Pro Ala Lys Asp Gly Glu Phe Ala Asp Lys Gln

50 55 60Asp Ile Ser Ala Phe Lys Ala Phe Thr Ile Ser Ala Ala Ser Arg Val 65 70 75 80Gly Thr Ala Asn Val Ala Gly Val Ala Leu Ala Ile Thr Leu Gly Gly

85 90 95Pro Gly Ala Val Phe Trp Met Trp Ile Ile Ala Leu Val Gly Gly Ala

100 105 110Thr Ser Phe Ile Glu Ser Thr Leu Gly Gln Leu Trp Lys Val Lys Asp

115 120 125Gly Asp Ser Tyr Arg Gly Gly Pro Ala Tyr Tyr Met Thr Leu Gly Leu

130 135 140Asn Ala Arg Trp Leu Ala Val Val Phe Gly Val Ala Ile Thr Leu Thr145 150 155 160Phe Gly Phe Val Tyr Asn Ala Leu Gln Ser Asn Ala Val Val Glu Ala

165 170 175Ile Thr Val Ser Leu Gly Thr Pro Ser Thr Thr Ala Lys Ala Phe Val

180 185 190Gly Leu Gly Met Ala Gly Leu Ser Ala Leu Val Ile Phe Gly Gly Val

195 200 205Gln Arg Ile Ala Asn Val Thr Gln Trp Met Val Pro Phe Met Ala Gly

210 215 220Ala Tyr Ile Ile Val Gly Val Val Val Ile Val Ile Asn Ile Gln Gln225 230 235 240Val Pro Thr Met Ile Asn Asp Ile Ile Ala Gly Ala Phe Gly Phe Arg

245 250 255Pro Val Ala Thr Ala Ser Val Trp Gly Ala Phe Trp Leu Ala Phe Met

260 265 270Asn Gly Met Arg Arg Gly Leu Phe Ser Asn Glu Ala Gly Glu Gly Ser

275 280 285Val Pro Asn Ala Ala Ala Thr Ala Thr Val Ser His Pro Val Lys Gln

290 295 300Gly Leu Val Gln Thr Leu Gly Val Tyr Phe Asp Thr Leu Leu Val Cys305 310 315 320Ser Ile Thr Ala Phe Val Ile Leu Leu Ser Gly Val Glu Tyr Ala Thr

325 330 335Gly Asp Ile Gln Ser Ser Ser Leu Thr Gln Ser Ala Leu Ala Ser Val

340 345 350Val Gly Gly Trp Gly Thr His Phe Ile Thr Val Val Met Phe Phe Leu

355 360 365Ala Phe Ser Ser Val Leu Gly AsnTyr Tyr Leu Ala Gln Ala Asn Ile

370 375 380Gln Tyr Phe Thr Asp Ser Lys Thr Val Met Thr Val Phe Arg Leu Leu385 390 395 400Val Leu Leu Ser Val Phe Ser Gly Ala Val Ala Ser Val Pro Leu Ile

405 410 415Trp Ala Leu Gly Asp Thr Phe Ala Gly Ile Met Val Leu Ile Asn Leu

420 425 430Ala Ala Ile Ile Pro Leu Gly Gly Val Ala Val Lys Leu Leu Lys Asn

435 440 445Tyr Thr Ile Gln Lys Lys Ala Gly Leu Asp Pro Val Phe His Arg Asp

450 455 460Met Met Pro Glu Val Arg Asn Ile Ala Cys Trp Asn Gly Lys Asp Ala465 470 475 480Ala Thr Ser Asn Tyr His Glu Ala Met Glu Val Ile Lys Lys Ser

485490495<210>633<211>914<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (891)<223>FRXA00432<400>633ttg tct gcg ctg gtt att ttt ggc ggc gtg cag cgt atc gca aac gtg 48Leu Ser Ala Leu Val Ile Phe Gly Gly Val Gln Arg Ile Ala Asn Val 151015 acg cag tgg atg gtt ccg ttc atg gcg ggt gcg tac atc att gtg ggt 96Thr Gln Trp Met Val Pro Phe Met Ala Gly Ala Tyr Ile Ile Val Gly

20 25 30gtg gtg gtg att gtg att aac att cag cag gtt ccg acc atg atc aac 144Val Val Val Ile Val Ile Asn Ile Gln Gln Val Pro Thr Met Ile Asn

35 40 45gac atc att gct ggt gct ttt ggt ttc cgt ccg gtt gct act gcg tcg 192Asp Ile Ile Ala Gly Ala Phe Gly Phe Arg Pro Val Ala Thr Ala Ser

5055 60gtg tgg ggc gcg ttc tgg ttg gcg ttt atg aac ggt atg cgc cgt gga 240Val Trp Gly Ala Phe Trp Leu Ala Phe Met Asn Gly Met Arg Arg Gly 65 70 75 80ctg ttc tcc aat gag gct ggt gag ggt tct gtc ccg aac gct gct gct 288Leu Phe Ser Asn Glu Ala Gly Glu Gly Ser Val Pro Asn Ala Ala Ala

85 90 95acc gcg act gtg tct cac cct gtg aag cag ggt ttg gtt cag act ctg 336Thr Ala Thr Val Ser His Pro Val Lys Gln Gly Leu Val Gln Thr Leu

100 105 110ggc gta tat ttc gac acc ctg ctc gtt tgt agc att acc gct ttt gtc 384Gly Val Tyr Phe Asp Thr Leu Leu Val Cys Ser Ile Thr Ala Phe Val

115 120 125atc ctg ctg tct gga gtg gag tac gcg acc ggc gat att cag tct tct 432Ile Leu Leu Ser Gly Val Glu Tyr Ala Thr Gly Asp Ile Gln Ser Ser

130 135 140tct ttg act cag tcc gcg ctg gct agc gtt gtt ggt ggt tgg gga acc 480Ser Leu Thr Gln Ser Ala Leu Ala Ser Val Val Gly Gly Trp Gly Thr145 150 155 160cac ttc att acc gta gtg atg ttc ttc ctg gcg ttt tct tcc gtg ctg 528His Phe Ile Thr Val Val Met Phe Phe Leu Ala Phe Ser Ser Val Leu

165 170 175ggt aac tac tac ttg gca cag gcg aat att cag tac ttc acc gat tcg 576Gly Asn Tyr Tyr Leu Ala Gln Ala Asn Ile Gln Tyr Phe Thr Asp Ser

180 185 190aag act gtc atg act gtt ttc cga ctc ttg gtg ctg ctc agc gtg ttc 624Lys Thr Val Met Thr Val Phe Arg Leu Leu Val Leu Leu Ser Val Phe

195 200 205tct ggc gcg gtt gct tcg gtg ccg ttg atc tgg gct ttg ggt gatact 672Ser Gly Ala Val Ala Ser Val Pro Leu Ile Trp Ala Leu Gly Asp Thr

210 215 220ttc gct ggc atc atg gtg ctc att aac ctg gcg gcg atc att ccg ctg 720Phe Ala Gly Ile Met Val Leu Ile Asn Leu Ala Ala Ile Ile Pro Leu225 230 235 240ggt ggc gtt gca gtg aag ttg ctt aag aat tac acc att cag aag aag 768Gly Gly Val Ala Val Lys Leu Leu Lys Asn Tyr Thr Ile Gln Lys Lys

245 250 255gct ggt ctg gat cct gtg ttc cac cgc gac atg atg cca gag gtt cgt 816Ala Gly Leu Asp Pro Val Phe His Arg Asp Met Met Pro Glu Val Arg

260 265 270aat att gcg tgc tgg aac ggc aaa gat gca gct aca tcc aac tat cac 864Asn Ile Ala Cys Trp Asn Gly Lys Asp Ala Ala Thr Ser Asn Tyr His

275 280 285gaa gcg atg gaa gtg atc aag aag agc tagtcatcga aggaacagtg 911Glu Ala Met Glu Val Ile Lys Lys Ser

290295 gta 914<210>634<211>297<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>634Leu Ser Ala Leu Val Ile Phe Gly Gly Val Gln Arg Ile Ala Asn Val 151015 Thr Gln Trp Met Val Pro Phe Met Ala Gly Ala Tyr Ile Ile Val Gly

20 25 30Val Val Val Ile Val Ile Asn Ile Gln Gln Val Pro Thr Met Ile Asn

35 40 45Asp Ile Ile Ala Gly Ala Phe Gly Phe Arg Pro Val Ala Thr Ala Ser

50 55 60Val Trp Gly Ala Phe Trp Leu Ala Phe Met Asn Gly Met Arg Arg Gly 65 70 75 80Leu Phe Ser Asn Glu Ala Gly Glu Gly Ser Val Pro Asn Ala Ala Ala

85 90 95Thr Ala Thr Val Ser His Pro Val Lys Gln Gly Leu Val Gln Thr Leu

100 105 110Gly Val Tyr Phe Asp Thr Leu Leu Val Cys Ser Ile Thr Ala Phe Val

115 120 125Ile Leu Leu Ser Gly Val Glu Tyr Ala Thr Gly Asp Ile Gln Ser Ser

130 135 140Ser Leu Thr Gln Ser Ala Leu Ala Ser Val Val Gly Gly Trp Gly Thr145 150 155 160His Phe Ile Thr Val Val Met Phe Phe Leu Ala Phe Ser Ser Val Leu

165 170 175Gly Asn Tyr Tyr Leu Ala Gln Ala Asn Ile Gln Tyr Phe Thr Asp Ser

180 185 190Lys Thr Val Met Thr Val Phe Arg Leu Leu Val Leu Leu Ser Val Phe

195 200 205Ser Gly Ala Val Ala Ser Val Pro Leu Ile Trp Ala Leu Gly Asp Thr

210 215 220Phe Ala Gly Ile Met Val Leu Ile Asn Leu Ala Ala Ile Ile Pro Leu225 230 235 240Gly Gly Val Ala Val Lys Leu Leu Lys Asn Tyr Thr Ile Gln Lys Lys

245 250 255Ala Gly Leu Asp Pro Val Phe His Arg Asp Met Met Pro Glu Val Arg

260 265 270Asn Ile Ala Cys Trp Asn Gly Lys Asp Ala Ala Thr Ser Asn Tyr His

275 280 285Glu Ala Met Glu Val Ile Lys Lys Ser

290295<210>635<211>569<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(45). (569)<223>FRXA00436<400>635gggatttact aaaaatcggg taacacgcgc gtagtatttt tcgc atg gaa tta ttg 56

Met Glu Leu Leu

1gag acc ttc atc act gat gtc att aat gac aat ttg tgg atg atc ttg 104Glu Thr Phe Ile Thr Asp Val Ile Asn Asp Asn Leu Trp Met Ile Leu 5 10 15 20ccc ttc ttg ctc gtt gct gct ggc ctc tat ttc ggt ggg cgt acg ttg 152Pro Phe Leu Leu Val Ala Ala Gly Leu Tyr Phe Gly Gly Arg Thr Leu

25 30 35ctg gtt cag att cgg atg att ccg gag atg ttc aaa gcg gtc gtc gag 200Leu Val Gln Ile Arg Met Ile Pro Glu Met Phe Lys Ala Val Val Glu

40 45 50aag cct gcg aag gat ggg gag ttc gcg gac aag cag gac att tcg gct 248Lys Pro Ala Lys Asp Gly Glu Phe Ala Asp Lys Gln Asp Ile Ser Ala

55 60 65ttt aag gcg ttc acg att tct gcg gcg tcg cga gtt ggt acg gcg aat 296Phe Lys Ala Phe Thr Ile Ser Ala Ala Ser Arg Val Gly Thr Ala Asn

70 75 80gtt gcg ggt gtt gcg ctg gcg atc act ctg ggt gga ccg ggt gca gtg 344Val Ala Gly Val Ala Leu Ala Ile Thr Leu Gly Gly Pro Gly Ala Val 85 90 95 100ttc tgg atg tgg atc att gcg ctg gtt ggc ggt gcg aca tcg ttc att 392Phe Trp Met Trp Ile Ile Ala Leu Val Gly Gly Ala Thr Ser Phe Ile

105 110 115gag tcg act ctt gga cag ttg tgg aag gtg aag gac ggc gac agc tat 440Glu Ser Thr Leu Gly Gln Leu Trp Lys Val Lys Asp Gly Asp Ser Tyr

120 125 130cgc ggt ggc cct gcg tac tac atg acg ctt ggt ttg aat gct cgg tgg 488Arg Gly Gly Pro Ala Tyr Tyr Met Thr Leu Gly Leu Asn Ala Arg Trp

135 140 145ctt gcg gtt gtt ttc ggt gtc gcc atc acg ttg acc ttt ggt ttt gtg 536Leu Ala Val Val Phe Gly Val Ala Ile Thr Leu Thr Phe Gly Phe Val

150155160 tac aac gct ttg cag tcc aac gcg gtt gtt gag 569Tyr Asn Ala Leu Gln Ser Asn Ala Val Val Glu 165170175 165170170175<210>636<211>175<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>636Met Glu Leu Leu Glu Thr Phe Ile Thr Asp Val Ile Asn Asp Asn Leu 151015 Trp Met Ile Leu Pro Phe Leu Leu Val Ala Ala Gly Leu Tyr Phe Gly

20 25 30Gly Arg Thr Leu Leu Val Gln Ile Arg Met Ile Pro Glu Met Phe Lys

35 40 45Ala Val Val Glu Lys Pro Ala Lys Asp Gly Glu Phe Ala Asp Lys Gln

50 55 60Asp Ile Ser Ala Phe Lys Ala Phe Thr Ile Ser Ala Ala Ser Arg Val 65 70 75 80Gly Thr Ala Asn Val Ala Gly Val Ala Leu Ala Ile Thr Leu Gly Gly

85 90 95Pro Gly Ala Val Phe Trp Met Trp Ile Ile Ala Leu Val Gly Gly Ala

100 105 110Thr Ser Phe Ile Glu Ser Thr Leu Gly Gln Leu Trp Lys Val Lys Asp

115 120 125Gly Asp Ser Tyr Arg Gly Gly Pro Ala Tyr Tyr Met Thr Leu Gly Leu

130 135 140Asn Ala Arg Trp Leu Ala Val Val Phe Gly Val Ala Ile Thr Leu Thr145 150 155 160Phe Gly Phe ValTyr Asn Ala Leu Gln Ser Asn Ala Val Val Glu

165170175<210>637<211>1572<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (1549)<223>RXA00847<400>637tctggcccgc tgtgtcctct ggacgcagcg ggccagtagt attttggggg tgagaataag 60gtttggaatt ctaagtgttg tcgcctgcac ggtttcgttg gtg gca tgt cag gct 115

Val Ala Cys Gln Ala

1 5aat ccg ggt cct gcg ccc gtt gag gag cca act aca gcc act gcg acg 163Asn Pro Gly Pro Ala Pro Val Glu Glu Pro Thr Thr Ala Thr Ala Thr

10 15 20acc acg gca act gag acg acc acc gta gag act gaa gcc ccc aaa caa 211Thr Thr Ala Thr Glu Thr Thr Thr Val Glu Thr Glu Ala Pro Lys Gln

25 30 35gat cgg gaa acc atc agt att ggt atc gat ccg atc cgc aac ggt ttc 259Asp Arg Glu Thr Ile Ser Ile Gly Ile Asp Pro Ile Arg Asn Gly Phe

40 45 50aat cca cat ttg ttg tct gat gat tct cca ctg gtg cgc gat act gca 307Asn Pro His Leu Leu Ser Asp Asp Ser Pro Leu Val Arg Asp Thr Ala

55 60 65tcg ttg gtg ttg ccg agt gct ttt gag ggc aat cag ctg aac act gac 355Ser Leu Val Leu Pro Ser Ala Phe Glu Gly Asn Gln Leu Asn Thr Asp 70 75 80 85ttg ttg gac aat gtt gag cag gtg gat gaa acc acg gtg agg tac acg 403Leu Leu Asp Asn Val Glu Gln Val Asp Glu Thr Thr Val Arg Tyr Thr

90 95 100att gct cag gaa gcg cag tgg agt gat ggc act ccg att act ggg tct 451Ile Ala Gln Glu Ala Gln Trp Ser AspGly Thr Pro Ile Thr Gly Ser

105 110 115gat ttt gag tac ttg cgc agg tcc att gtg gcg ggg aca gga acg ctg 499Asp Phe Glu Tyr Leu Arg Arg Ser Ile Val Ala Gly Thr Gly Thr Leu

120 125 130aac gat tct gca tat tcg gcg att tca gag att agg acc tca ggc ggt 547Asn Asp Ser Ala Tyr Ser Ala Ile Ser Glu Ile Arg Thr Ser Gly Gly

135 140 145gga aaa act gtc gac gtt att ttt gaa cat cct gtc gct gat tgg cat 595Gly Lys Thr Val Asp Val Ile Phe Glu His Pro Val Ala Asp Trp His150 155 160 165ttg ctg ttt aac aat ttg ttg ccg agt cat ttg atc act ggc aat tcc 643Leu Leu Phe Asn Asn Leu Leu Pro Ser His Leu Ile Thr Gly Asn Ser

170 175 180aca ttc cag aca gcg ttt tat gat tcc atc ccg gcc tct gcg ggg cgc 691Thr Phe Gln Thr Ala Phe Tyr Asp Ser Ile Pro Ala Ser Ala Gly Arg

185 190 195tac atg gtg cgt tcc att gat cgt cag cgc ggc gtg att acg ttg tcg 739Tyr Met Val Arg Ser Ile Asp Arg Gln Arg Gly Val Ile Thr Leu Ser

200 205 210cgc aat gat cgt ttc tgg ggt gca aat ccg gca cac gtg gaa gta ctc 787Arg Asn Asp Arg Phe Trp Gly Ala Asn Pro Ala His Val Glu Val Leu

215 220 225caa ttc aac acc gtt gcc tct gca tcc cgg gcg ggg gag tac ctg cgc 835Gln Phe Asn Thr Val Ala Ser Ala Ser Arg Ala Gly Glu Tyr Leu Arg230 235 240 245acc ggg cag agt tcg ttt atg aat ctg tca ccg cag gaa acc ctg gtg 883Thr Gly Gln Ser Ser Phe Met Asn Leu Ser Pro Gln Glu Thr Leu Val

250 255260gac acg ttg aat ttg gtg ccg gac acg gaa gtg cgg gtg tct gac acg 931Asp Thr Leu Asn Leu Val Pro Asp Thr Glu Val Arg Val Ser Asp Thr

265 270 275acg cgc acg ctg gag ctg gta ttc aac gcc gaa gcg ctg gca ccg gcg 979Thr Arg Thr Leu Glu Leu Val Phe Asn Ala Glu Ala Leu Ala Pro Ala

280 285 290cag cgc gcc tac ctg aca tcg ctt atc gac gtc ccc ctc acc gcc aag 1027Gln Arg Ala Tyr Leu Thr Ser Leu Ile Asp Val Pro Leu Thr Ala Lys

295 300 305tta gct ggc ggt cgc agt gca aac ctg ggt gtg ccc caa acg gtg gag 1075Leu Ala Gly Gly Arg Ser Ala Asn Leu Gly Val Pro Gln Thr Val Glu310 315 320 325gcg agc gtc gat aag caa gaa att cct gcg ttg cgc ctg gcg gcg gac 1123Ala Ser Val Asp Lys Gln Glu Ile Pro Ala Leu Arg Leu Ala Ala Asp

330 335 340ccc gcc gac gat gct ggt ttg gca gct gcg cgg ggc atc gtc gat atg 1171Pro Ala Asp Asp Ala Gly Leu Ala Ala Ala Arg Gly Ile Val Asp Met

345 350 355ctg gct gcg gat gga atc aag gct cag gtc gtg aca acc gat ttg aat 1219Leu Ala Ala Asp Gly Ile Lys Ala Gln Val Val Thr Thr Asp Leu Asn

360 365 370tcg gcg att gcg ggt aat ttt gat gcg atc gtg gcg tgg acc aga act 1267Ser Ala Ile Ala Gly Asn Phe Asp Ala Ile Val Ala Trp Thr Arg Thr

375 380 385gcc acg gat tcg att gcg ttg gcg gac cga gtg ggt tgt ggc gtg aac 1315Ala Thr Asp Ser Ile Ala Leu Ala Asp Arg Val Gly Cys Gly Val Asn390 395 400 405ttg gca aag tgg tgc gct gag gga acc acg gaa tat atc aac ggt gtt 1363Leu Ala LysTrp Cys Ala Glu Gly Thr Thr Glu Tyr Ile Asn Gly Val

410 415 420ttg gcg ggt gag att gat ttc gat cct gcg tgg gag cag cag ttt aac 1411Leu Ala Gly Glu Ile Asp Phe Asp Pro Ala Trp Glu Gln Gln Phe Asn

425 430 435acc gag aat cac ttg cgg gtt ccg atc ctg cgg gag act cgg gta gaa 1459Thr Glu Asn His Leu Arg Val Pro Ile Leu Arg Glu Thr Arg Val Glu

440 445 450gcg aaa aat aac ggt atc ctc ggg gct gcg gat ggc tgg cct ggg gga 1507Ala Lys Asn Asn Gly Ile Leu Gly Ala Ala Asp Gly Trp Pro Gly Gly

455460465 att tca agt gct gca agt tgg agg aaa aac gat gtt gaa gaa 1549Ile Ser Ser Ala Ala Ser Trp Arg Lys Asn Asp Val Glu Glu 470475480 tgatctgct ggtgctcgag ttg 1572<210>638<211>483<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>638Val Ala Cys Gln Ala Asn Pro Gly Pro Ala Pro Val Glu Glu Pro Thr 151015 Thr Ala Thr Ala Thr Thr Thr Ala Thr Glu Thr Thr Thr Val Glu Thr

20 25 30Glu Ala Pro Lys Gln Asp Arg Glu Thr Ile Ser Ile Gly Ile Asp Pro

35 40 45Ile Arg Asn Gly Phe Asn Pro His Leu Leu Ser Asp Asp Ser Pro Leu

50 55 60Val Arg Asp Thr Ala Ser Leu Val Leu Pro Ser Ala Phe Glu Gly Asn 65 70 75 80Gln Leu Asn Thr Asp Leu Leu Asp Asn Val Glu Gln Val Asp Glu Thr

85 90 95Thr Val Arg Tyr Thr Ile Ala Gln Glu Ala Gln Trp Ser Asp Gly Thr

100 105 110Pro Ile Thr Gly Ser Asp Phe Glu Tyr Leu Arg Arg Ser Ile Val Ala

115 120 125Gly Thr Gly Thr Leu Asn Asp Ser Ala Tyr Ser Ala Ile Ser Glu Ile

130 135 140Arg Thr Ser Gly Gly Gly Lys Thr Val Asp Val Ile Phe Glu His Pro145 150 155 160Val Ala Asp Trp His Leu Leu Phe Asn Asn Leu Leu Pro Ser His Leu

165 170 175Ile Thr Gly Asn Ser Thr Phe Gln Thr Ala Phe Tyr Asp Ser Ile Pro

180 185 190Ala Ser Ala Gly Arg Tyr Met Val Arg Ser Ile Asp Arg Gln Arg Gly

195 200 205Val Ile Thr Leu Ser Arg Asn Asp Arg Phe Trp Gly Ala Asn Pro Ala

210 215 220His Val Glu Val Leu Gln Phe Asn Thr Val Ala Ser Ala Ser Arg Ala225 230 235 240Gly Glu Tyr Leu Arg Thr Gly Gln Ser Ser Phe Met Asn Leu Ser Pro

245 250 255Gln Glu Thr Leu Val Asp Thr Leu Asn Leu Val Pro Asp Thr Glu Val

260 265 270Arg Val Ser Asp Thr Thr Arg Thr Leu Glu Leu Val Phe Asn Ala Glu

275 280 285Ala Leu Ala Pro Ala Gln Arg Ala Tyr Leu Thr Ser Leu Ile Asp Val

290 295 300Pro Leu Thr Ala Lys Leu Ala Gly Gly Arg Ser Ala Asn Leu Gly Val305 310 315 320Pro Gln Thr Val Glu Ala Ser Val Asp Lys Gln Glu Ile Pro Ala Leu

325 330 335Arg Leu Ala Ala Asp Pro Ala Asp Asp Ala Gly Leu Ala Ala Ala Arg

340 345 350Gly Ile Val Asp Met Leu Ala Ala Asp Gly Ile Lys Ala Gln Val Val

355 360 365Thr Thr Asp Leu Asn Ser Ala Ile Ala Gly Asn Phe Asp Ala Ile Val

370 375 380Ala Trp Thr Arg Thr Ala Thr Asp Ser Ile Ala Leu Ala Asp Arg Val385 390 395 400Gly Cys Gly Val Asn Leu Ala Lys Trp Cys Ala Glu Gly Thr Thr Glu

405 410 415Tyr Ile Asn Gly Val Leu Ala Gly Glu Ile Asp Phe Asp Pro Ala Trp

420 425 430Glu Gln Gln Phe Asn Thr Glu Asn His Leu Arg Val Pro Ile Leu Arg

435 440 445Glu Thr Arg Val Glu Ala Lys Asn Asn Gly Ile Leu Gly Ala Ala Asp

450455460 Gly Trp Pro Gly Gly Ile Ser Ser Ala Ala Ser Trp Arg Lys Asn Asp 465470475480 ValGlu Glu<210>639<211>1192<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1192)<223>RXN01382<400>639aaaggatgta cctcatgagc accacgatta ctcgccgcaa tttcctccga gcaaccggaa 60tcctcggtgt cgcagctggc atcggcgcaa cacttgctgc atg tgc acc aac aac 115

Met Cys Thr Asn Asn

1 5acc ggc acc agc gga tcc acc tcc acc gca gct ggc acc gga act gca 163Thr Gly Thr Ser Gly Ser Thr Ser Thr Ala Ala Gly Thr Gly Thr Ala

10 15 20aat gaa gaa ggc acc atc acc gca gcc atc tcc tac gaa ctg gga acc 211Asn Glu Glu Gly ThrIle Thr Ala Ala Ile Ser Tyr Glu Leu Gly Thr

25 30 35aac ggc tac gac cca atg acc acc acc tcg gct ctc act gtg gca gcc 259Asn Gly Tyr Asp Pro Met Thr Thr Thr Ser Ala Leu Thr Val Ala Ala

40 45 50aac tgg cac acc ctt gaa ggc ctc acc gaa atc gac cca gcc acc ggc 307Asn Trp His Thr Leu Glu Gly Leu Thr Glu Ile Asp Pro Ala Thr Gly

55 60 65gag gtc tac gca gca ctc gcc agc gca ctg cct tca gcc gat gcg acc 355Glu Val Tyr Ala Ala Leu Ala Ser Ala Leu Pro Ser Ala Asp Ala Thr 70 75 80 85tcc cta gac atc aag ctt cgc gac ggc gcc acc ttc cac aac ggc gac 403Ser Leu Asp Ile Lys Leu Arg Asp Gly Ala Thr Phe His Asn Gly Asp

90 95 100gca gtc acc gca gac gac gta gtc ttc tct ttt gag cga gtc ctc gat 451Ala Val Thr Ala Asp Asp Val Val Phe Ser Phe Glu Arg Val Leu Asp

105 110 115cca gcc aac aac tcc ctt tac gca tcc ttc atc cca ttc atc aag tca 499Pro Ala Asn Asn Ser Leu Tyr Ala Ser Phe Ile Pro Phe Ile Lys Ser

120 125 130gtc acc aag aag gat gac acc acc gtc acc atc gac ctc gac tac gca 547Val Thr Lys Lys Asp Asp Thr Thr Val Thr Ile Asp Leu Asp Tyr Ala

135 140 145acc ggc atc atc agc gaa cgc ctc gca gta gta aag atc gtg cca aag 595Thr Gly Ile Ile Ser Glu Arg Leu Ala Val Val Lys Ile Val Pro Lys150 155 160 165tcc gtc gtg gaa gca gac gca tcc gga ttc gac gcc aac cca atc ggc 643Ser Val Val Glu Ala Asp Ala Ser Gly Phe Asp Ala Asn Pro Ile Gly

170175 180tcc ggc cca tac aag atg acc gac aac ggt gca tcc aag gtg gtc aag 691Ser Gly Pro Tyr Lys Met Thr Asp Asn Gly Ala Ser Lys Val Val Lys

185 190 195ttc gag cgc aac gac gac tac aac ggc cca cgc cca gca cgt gcc gcc 739Phe Glu Arg Asn Asp Asp Tyr Asn Gly Pro Arg Pro Ala Arg Ala Ala

200 205 210aag atg gaa tgg cag atc atc ccc gac gcc tcc acc cgc acc aac tcc 787Lys Met Glu Trp Gln Ile Ile Pro Asp Ala Ser Thr Arg Thr Asn Ser

215 220 225ctt cag tcc ggc agc acc atg gcc atc gac tcc gtt cca tac ctg tcg 835Leu Gln Ser Gly Ser Thr Met Ala Ile Asp Ser Val Pro Tyr Leu Ser230 235 240 245atc cca cag ctt gaa gcc acc agc acc gta gaa tcc gtc caa gga ttc 883Ile Pro Gln Leu Glu Ala Thr Ser Thr Val Glu Ser Val Gln Gly Phe

250 255 260ggc ctc ctg ttc gcc atg ttc agc tgc tcc gaa ggc aac ccc ttc aac 931Gly Leu Leu Phe Ala Met Phe Ser Cys Ser Glu Gly Asn Pro Phe Asn

265 270 275gac gtc cgc aac cgc cag gca ttc ctc tac gca ctg gac atg gac aag 979Asp Val Arg Asn Arg Gln Ala Phe Leu Tyr Ala Leu Asp Met Asp Lys

280 285 290atc gtt aag acc ggc atg tcc gac cag gca acc cca gcc acc tcc ttc 1027Ile Val Lys Thr Gly Met Ser Asp Gln Ala Thr Pro Ala Thr Ser Phe

295 300 305gtg cag aag gaa cac ccc aac tac aac cag gca tcc acg gtc tac tcc 1075Val Gln Lys Glu His Pro Asn Tyr Asn Gln Ala Ser Thr Val Tyr Ser310 315 320 325ctc gac gcc gac aaa gcc aag gcg ctg ttc gct gaa acc ggc ctt acc 1123Leu Asp Ala Asp LysAla Lys Ala Leu Phe Ala Glu Thr Gly Leu Thr

330 335 340agc ctc aac ctc ctg tgc acc gac cac gac tgg gtc aag aac tgc acc 1171Ser Leu Asn Leu Leu Cys Thr Asp His Asp Trp Val Lys Asn Cys Thr

345 350 355cca ctg atc cag gaa tcc ctc 1192Pro Leu Ile Gln Glu Ser Leu

360<210>640<211>364<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>640Met Cys Thr Asn Asn Thr Gly Thr Ser Gly Ser Thr Ser Thr Ala Ala 151015 Gly Thr Gly Thr Ala Asn Glu Glu Gly Thr Ile Thr Ala Ala Ile Ser

20 25 30Tyr Glu Leu Gly Thr Asn Gly Tyr Asp Pro Met Thr Thr Thr Ser Ala

35 40 45Leu Thr Val Ala Ala Asn Trp His Thr Leu Glu Gly Leu Thr Glu Ile

50 55 60Asp Pro Ala Thr Gly Glu Val Tyr Ala Ala Leu Ala Ser Ala Leu Pro 65 70 75 80Ser Ala Asp Ala Thr Ser Leu Asp Ile Lys Leu Arg Asp Gly Ala Thr

85 90 95Phe His Asn Gly Asp Ala Val Thr Ala Asp Asp Val Val Phe Ser Phe

100 105 110Glu Arg Val Leu Asp Pro Ala Asn Asn Ser Leu Tyr Ala Ser Phe Ile

115 120 125Pro Phe Ile Lys Ser Val Thr Lys Lys Asp Asp Thr Thr Val Thr Ile

130 135 140Asp Leu Asp Tyr Ala Thr Gly Ile Ile Ser Glu Arg Leu Ala Val Val145 150 155 160Lys Ile Val Pro Lys Ser Val Val Glu Ala Asp Ala Ser Gly Phe Asp

165 170 175Ala Asn Pro Ile Gly Ser Gly Pro Tyr Lys Met Thr Asp Asn Gly Ala

180 185 190Ser Lys Val Val Lys Phe Glu Arg Asn Asp Asp Tyr Asn Gly Pro Arg

195 200 205Pro Ala Arg Ala Ala Lys Met Glu Trp Gln Ile Ile Pro Asp Ala Ser

210 215 220Thr Arg Thr Asn Ser Leu Gln Ser Gly Ser Thr Met Ala Ile Asp Ser225 230 235 240Val Pro Tyr Leu Ser Ile Pro Gln Leu Glu Ala Thr Ser Thr Val Glu

245 250 255Ser Val Gln Gly Phe Gly Leu Leu Phe Ala Met Phe Ser Cys Ser Glu

260 265 270Gly Asn Pro Phe Asn Asp Val Arg Asn Arg Gln Ala Phe Leu Tyr Ala

275 280 285Leu Asp Met Asp Lys Ile Val Lys Thr Gly Met Ser Asp Gln Ala Thr

290 295 300Pro Ala Thr Ser Phe Val Gln Lys Glu His Pro Asn Tyr Asn Gln Ala305 310 315 320Ser Thr Val Tyr Ser Leu Asp Ala Asp Lys Ala Lys Ala Leu Phe Ala

325 330 335Glu Thr Gly Leu Thr Ser Leu Asn Leu Leu Cys Thr Asp His Asp Trp

340 345 350Val Lys Asn Cys Thr Pro Leu Ile Gln Glu Ser Leu

355360<210>641<211>1062<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1). (1062)<223>FRXA01382<400>641tcc acc tcc acc gca gct ggc acc gga act gca aat gaa gaa ggc acc 48Ser Thr Ser Thr Ala Ala Gly Thr Gly Thr Ala Asn Glu Glu Gly Thr 151015 atc acc gca gcc atc tcc tac gaa ctg gga acc aac ggc tac gac cca 96Ile Thr Ala Ala Ile Ser Tyr Glu Leu Gly Thr Asn Gly Tyr Asp Pro

20 25 30atg acc acc acc tcg gct ctc act gtg gca gcc aac tgg cac acc ctt 144Met Thr Thr Thr Ser Ala Leu Thr Val Ala Ala Asn Trp His Thr Leu

35 40 45gaa ggc ctc acc gaa atc gac cca gcc acc ggc gag gtc tac gca gca 192Glu Gly Leu Thr Glu Ile Asp Pro Ala Thr Gly Glu Val Tyr Ala Ala

50 55 60ctc gcc agc gca ctg cct tca gcc gat gcg acc tcc cta gac atc aag 240Leu Ala Ser Ala Leu Pro Ser Ala Asp Ala Thr Ser Leu Asp Ile Lys 65 70 75 80ctt cgc gac ggc gcc acc ttc cac aac ggc gac gca gtc acc gca gac 288Leu Arg Asp Gly Ala Thr Phe His Asn Gly Asp Ala Val Thr Ala Asp

85 90 95gac gta gtc ttc tct ttt gag cga gtc ctc gat cca gcc aac aac tcc 336Asp Val Val Phe Ser Phe Glu Arg Val Leu Asp Pro Ala Asn Asn Ser

100 105 110ctt tac gca tcc ttc atc cca ttc atc aag tca gtc acc aag aag gat 384Leu Tyr Ala Ser Phe Ile Pro Phe Ile Lys Ser Val Thr Lys Lys Asp

115 120 125gac acc acc gtc acc atc gac ctc gac tac gca acc ggc atc atc agc 432Asp Thr Thr Val Thr Ile Asp Leu Asp Tyr Ala Thr Gly Ile Ile Ser

130 135 140gaa cgc ctc gca gta gta aag atc gtg cca aag tcc gtc gtg gaa gca 480Glu Arg Leu Ala Val Val Lys Ile Val Pro Lys Ser Val Val Glu Ala145 150155 160gac gca tcc gga ttc gac gcc aac cca atc ggc tcc ggc cca tac aag 528Asp Ala Ser Gly Phe Asp Ala Asn Pro Ile Gly Ser Gly Pro Tyr Lys

165 170 175atg acc gac aac ggt gca tcc aag gtg gtc aag ttc gag cgc aac gac 576Met Thr Asp Asn Gly Ala Ser Lys Val Val Lys Phe Glu Arg Asn Asp

180 185 190gac tac aac ggc cca cgc cca gca cgt gcc gcc aag atg gaa tgg cag 624Asp Tyr Asn Gly Pro Arg Pro Ala Arg Ala Ala Lys Met Glu Trp Gln

195 200 205atc atc ccc gac gcc tcc acc cgc acc aac tcc ctt cag tcc ggc agc 672Ile Ile Pro Asp Ala Ser Thr Arg Thr Asn Ser Leu Gln Ser Gly Ser

210 215 220acc atg gcc atc gac tcc gtt cca tac ctg tcg atc cca cag ctt gaa 720Thr Met Ala Ile Asp Ser Val Pro Tyr Leu Ser Ile Pro Gln Leu Glu225 230 235 240gcc acc agc acc gta gaa tcc gtc caa gga ttc ggc ctc ctg ttc gcc 768Ala Thr Ser Thr Val Glu Ser Val Gln Gly Phe Gly Leu Leu Phe Ala

245 250 255atg ttc agc tgc tcc gaa ggc aac ccc ttc aac gac gtc cgc aac cgc 816Met Phe Ser Cys Ser Glu Gly Asn Pro Phe Asn Asp Val Arg Asn Arg

260 265 270cag gca ttc ctc tac gca ctg gac atg gac aag atc gtt aag acc ggc 864Gln Ala Phe Leu Tyr Ala Leu Asp Met Asp Lys Ile Val Lys Thr Gly

275 280 285atg tcc gac cag gca acc cca gcc acc tcc ttc gtg cag aag gaa cac 912Met Ser Asp Gln Ala Thr Pro Ala Thr Ser Phe Val Gln Lys Glu His

290 295 300ccc aac tac aac cag gca tcc acg gtctac tcc ctc gac gcc gac aaa 960Pro Asn Tyr Asn Gln Ala Ser Thr Val Tyr Ser Leu Asp Ala Asp Lys305 310 315 320gcc aag gcg ctg ttc gct gaa acc ggc ctt acc agc ctc aac ctc ctg 1008Ala Lys Ala Leu Phe Ala Glu Thr Gly Leu Thr Ser Leu Asn Leu Leu

325 330 335tgc acc gac cac gac tgg gtc aag aac tgc acc cca ctg atc cag gaa 1056Cys Thr Asp His Asp Trp Val Lys Asn Cys Thr Pro Leu Ile Gln Glu

340345350 tc ctc 1062Ser Leu<210>642<211>354<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>642Ser Thr Ser Thr Ala Ala Gly Thr Gly Thr Ala Asn Glu Glu Gly Thr 151015 Ile Thr Ala Ala Ile Ser Tyr Glu Leu Gly Thr Asn Gly Tyr Asp Pro

20 25 30Met Thr Thr Thr Ser Ala Leu Thr Val Ala Ala Asn Trp His Thr Leu

35 40 45Glu Gly Leu Thr Glu Ile Asp Pro Ala Thr Gly Glu Val Tyr Ala Ala

50 55 60Leu Ala Ser Ala Leu Pro Ser Ala Asp Ala Thr Ser Leu Asp Ile Lys 65 70 75 80Leu Arg Asp Gly Ala Thr Phe His Asn Gly Asp Ala Val Thr Ala Asp

85 90 95Asp Val Val Phe Ser Phe Glu Arg Val Leu Asp Pro Ala Asn Asn Ser

100 105 110Leu Tyr Ala Ser Phe Ile Pro Phe Ile Lys Ser Val Thr Lys Lys Asp

115 120 125Asp Thr Thr Val Thr Ile Asp Leu Asp Tyr Ala Thr Gly Ile Ile Ser

130 135 140Glu Arg Leu Ala Val Val Lys Ile Val Pro Lys Ser Val Val Glu Ala145 150155 160Asp Ala Ser Gly Phe Asp Ala Asn Pro Ile Gly Ser Gly Pro Tyr Lys

165 170 175Met Thr Asp Asn Gly Ala Ser Lys Val Val Lys Phe Glu Arg Asn Asp

180 185 190Asp Tyr Asn Gly Pro Arg Pro Ala Arg Ala Ala Lys Met Glu Trp Gln

195 200 205Ile Ile Pro Asp Ala Ser Thr Arg Thr Asn Ser Leu Gln Ser Gly Ser

210 215 220Thr Met Ala Ile Asp Ser Val Pro Tyr Leu Ser Ile Pro Gln Leu Glu225 230 235 240Ala Thr Ser Thr Val Glu Ser Val Gln Gly Phe Gly Leu Leu Phe Ala

245 250 255Met Phe Ser Cys Ser Glu Gly Asn Pro Phe Asn Asp Val Arg Asn Arg

260 265 270Gln Ala Phe Leu Tyr Ala Leu Asp Met Asp Lys Ile Val Lys Thr Gly

275 280 285Met Ser Asp Gln Ala Thr Pro Ala Thr Ser Phe Val Gln Lys Glu His

290 295 300Pro Asn Tyr Asn Gln Ala Ser Thr Val Tyr Ser Leu Asp Ala Asp Lys305 310 315 320Ala Lys Ala Leu Phe Ala Glu Thr Gly Leu Thr Ser Leu Asn Leu Leu

325 330 335Cys Thr Asp His Asp Trp Val Lys Asn Cys Thr Pro Leu Ile Gln Glu

340345350 Ser Leu<210>643<211>335<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (312)<223>RXA02659<400>643ttc ggc aac gac cca gac ctc ctc atg cgc tgg tgg tac gcc ggcgac 48Phe Gly Asn Asp Pro Asp Leu Leu Met Arg Trp Trp Tyr Ala Gly Asp 151015 gtc tgg acc gac tcc cgc atg cac tgg aag ggc agc gaa tcc tac gac 96Val Trp Thr Asp Ser Arg Met His Trp Lys Gly Ser Glu Ser Tyr Asp

20 25 30cag gta caa aac ctc ctg gaa gaa ggc atc cgc gct acc gac aag gca 144Gln Val Gln Asn Leu Leu Glu Glu Gly Ile Arg Ala Thr Asp Lys Ala

35 40 45gaa cag caa gac atc tgg aac cgc acc ttc gat gtc atc tcc gac aat 192Glu Gln Gln Asp Ile Trp Asn Arg Thr Phe Asp Val Ile Ser Asp Asn

50 55 60gtt ccc ctc tac ccg ctg ttc cac cgc aag gtc cca acc gca tgg aac 240Val Pro Leu Tyr Pro Leu Phe His Arg Lys Val Pro Thr Ala Trp Asn 65 70 75 80tcc aac gcc ctc gtc gac ttc aag cca atc tca ctc acc ggc ttg aac 288Ser Asn Ala Leu Val Asp Phe Lys Pro Ile Ser Leu Thr Gly Leu Asn

85 90 95ttc tca ggt gtt gca act act gaa taacaacccc agtggctttc aaa 335Phe Ser Gly Val Ala Thr Thr Glu

100<210>644<211>104<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>644Phe Gly Asn Asp Pro Asp Leu Leu Met Arg Trp Trp Tyr Ala Gly Asp 151015 Val Trp Thr Asp Ser Arg Met His Trp Lys Gly Ser Glu Ser Tyr Asp

20 25 30Gln Val Gln Asn Leu Leu Glu Glu Gly Ile Arg Ala Thr Asp Lys Ala

35 40 45Glu Gln Gln Asp Ile Trp Asn Arg Thr Phe Asp Val Ile Ser Asp Asn

50 55 60Val Pro Leu Tyr Pro Leu Phe His Arg Lys Val Pro Thr Ala Trp Asn 65 7075 80Ser Asn Ala Leu Val Asp Phe Lys Pro Ile Ser Leu Thr Gly Leu Asn

85 90 95Phe Ser Gly Val Ala Thr Thr Glu

100<210>645<211>933<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (910)<223>RXN02933<400>645tgatctgctg tatcaggtgg ttgatccaag agtcggtgct gttggggttg ctagcactaa 60ggttccaggg agcgtggctt aagtgacaac gatcaaaaac atg ccc ctt tca ggg 115

Met Pro Leu Ser Gly

1 5aaa atc ggc ggc ttc atc gtt gcc gtt gta ttt gtt ctt gct gcg ctg 163Lys Ile Gly Gly Phe Ile Val Ala Val Val Phe Val Leu Ala Ala Leu

10 15 20tct ttc att tgg act ccg ttt gat cca gtt caa gct ttc cca cag gag 211Ser Phe Ile Trp Thr Pro Phe Asp Pro Val Gln Ala Phe Pro Gln Glu

25 30 35cgc ctt gag gga agt tct ttg agg cac ctg ttg gga acg gat cgt tat 259Arg Leu Glu Gly Ser Ser Leu Arg His Leu Leu Gly Thr Asp Arg Tyr

40 45 50ggt cgc gat gtt tta tcc cag atc atg gtt ggt tcc cgc gtc acg ttg 307Gly Arg Asp Val Leu Ser Gln Ile Met Val Gly Ser Arg Val Thr Leu

55 60 65ttg gtg ggc atc att gcg gtg gcg atc gca gca tta atc ggc acg cca 355Leu Val Gly Ile Ile Ala Val Ala Ile Ala Ala Leu Ile Gly Thr Pro 70 75 80 85ctg ggt att gct gcg gga atg cgc cgt ggc atg gtg gaa acc ttt gtc 403Leu Gly Ile Ala Ala Gly Met Arg Arg Gly Met Val Glu Thr Phe Val

90 95 100atg cgt ggt gcc gat tta atg ttg gcg ttc cca gca ctg ttg ttg gcg 451Met Arg Gly Ala Asp Leu Met Leu Ala Phe Pro Ala Leu Leu Leu Ala

105 110 115att att tcc ggc gcc gtt ttc ggc gcc tcc acg tgg tcc gcg atg gtc 499Ile Ile Ser Gly Ala Val Phe Gly Ala Ser Thr Trp Ser Ala Met Val

120 125 130gcg atc ggc atc gca ggc atc cct agt ttt gcc cgc gtg gct cgt gca 547Ala Ile Gly Ile Ala Gly Ile Pro Ser Phe Ala Arg Val Ala Arg Ala

135 140 145ggc aca ttg cag gtg acc agt cag gat ttc atc gca gct gct cgg cta 595Gly Thr Leu Gln Val Thr Ser Gln Asp Phe Ile Ala Ala Ala Arg Leu150 155 160 165tca aaa gta agt tcc gcc cgg atc gcg ctt cgc cat att ttg ccc aac 643Ser Lys Val Ser Ser Ala Arg Ile Ala Leu Arg His Ile Leu Pro Asn

170 175 180atc acc agc atg ttg atc gtt cag gca tca gta gct ttt gcc ctg gcg 691Ile Thr Ser Met Leu Ile Val Gln Ala Ser Val Ala Phe Ala Leu Ala

185 190 195atc ctg gcg gaa gcc gca ttg agt ttc ctc ggt ttg ggc acc act ccc 739Ile Leu Ala Glu Ala Ala Leu Ser Phe Leu Gly Leu Gly Thr Thr Pro

200 205 210ccg gat ccc agc tgg ggt cgc atg ttg caa acc gct caa gca tcc atc 787Pro Asp Pro Ser Trp Gly Arg Met Leu Gln Thr Ala Gln Ala Ser Ile

215 220 225ggc gtc acc ccc atg ttg gcg gtg tgg ccc ggt gct gcg atc gct ttg 835Gly Val Thr Pro Met Leu Ala Val Trp Pro Gly Ala Ala Ile Ala Leu230 235 240 245acg gtc ctt ggt ttt aat ctt ttc ggt gat ggt tta cgc gat gcc atc 883Thr Val Leu Gly Phe Asn Leu Phe Gly Asp Gly Leu Arg Asp Ala Ile

250 255 260gat cca aag cgg gag gtc ggc cgt gct taaagtttct gatttaacgg 930Asp Pro Lys Arg Glu Val Gly Arg Ala

265270 ttg 933<210>646<211>270<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>646Met Pro Leu Ser Gly Lys Ile Gly Gly Phe Ile Val Ala Val Val Phe 151015 Val Leu Ala Ala Leu Ser Phe Ile Trp Thr Pro Phe Asp Pro Val Gln

20 25 30Ala Phe Pro Gln Glu Arg Leu Glu Gly Ser Ser Leu Arg His Leu Leu

35 40 45Gly Thr Asp Arg Tyr Gly Arg Asp Val Leu Ser Gln Ile Met Val Gly

50 55 60Ser Arg Val Thr Leu Leu Val Gly Ile Ile Ala Val Ala Ile Ala Ala 65 70 75 80Leu Ile Gly Thr Pro Leu Gly Ile Ala Ala Gly Met Arg Arg Gly Met

85 90 95Val Glu Thr Phe Val Met Arg Gly Ala Asp Leu Met Leu Ala Phe Pro

100 105 110Ala Leu Leu Leu Ala Ile Ile Ser Gly Ala Val Phe Gly Ala Ser Thr

115 120 125Trp Ser Ala Met Val Ala Ile Gly Ile Ala Gly Ile Pro Ser Phe Ala

130 135 140Arg Val Ala Arg Ala Gly Thr Leu Gln Val Thr Ser Gln Asp Phe Ile145 150 155 160Ala Ala Ala Arg Leu Ser Lys Val Ser Ser Ala Arg Ile Ala Leu Arg

165 170 175His Ile Leu Pro Asn Ile Thr Ser Met Leu Ile Val Gln Ala Ser Val

180 185 190Ala Phe Ala Leu Ala Ile Leu Ala Glu Ala Ala Leu Ser Phe Leu Gly

195 200 205Leu Gly Thr Thr Pro Pro Asp Pro Ser Trp Gly Arg Met Leu Gln Thr

210 215 220Ala Gln Ala Ser Ile Gly Val Thr Pro Met Leu Ala Val Trp Pro Gly225 230 235 240Ala Ala Ile Ala Leu Thr Val Leu Gly Phe Asn Leu Phe Gly Asp Gly

245 250 255Leu Arg Asp Ala Ile Asp Pro Lys Arg Glu Val Gly Arg Ala

260265270<210>647<211>715<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (715)<223>RXN02991<400>647ttgtcgtgtt cgcgatcttc gccgttggct tcatgattct gaccctgcct atgggccttg 60gcttgggcaa actctctgag cgtttggcgg tgaagaagta atg gct aat aca gtt 115

Met Ala Asn Thr Val

1 5cgc gca aca gtc ctc tac gat gct cct gga cca aag ggc cgt cga ttc 163Arg Ala Thr Val Leu Tyr Asp Ala Pro Gly Pro Lys Gly Arg Arg Phe

10 15 20aac ctc ata atc acc att ctc acg gtg gtt ctg gga ttg gcg ctc ctc 211Asn Leu Ile Ile Thr Ile Leu Thr Val Val Leu Gly Leu Ala Leu Leu

25 30 35ttc tgg att ggc tcc atg ctt tca ggc aac ggc caa ctc gat gcc aac 259Phe Trp Ile Gly Ser Met Leu Ser Gly Asn Gly Gln Leu Asp Ala Asn

40 45 50aaa tgg act ccg ttcatc aat tcc caa acc tgg acc acc tac att ctt 307Lys Trp Thr Pro Phe Ile Asn Ser Gln Thr Trp Thr Thr Tyr Ile Leu

55 60 65cct ggt ttg tgg ggc acg ctg aaa tct gcc gtg ttc tcg gtg atc ttg 355Pro Gly Leu Trp Gly Thr Leu Lys Ser Ala Val Phe Ser Val Ile Leu 70 75 80 85gct ctg gtc atg ggt acc gca ctg ggt ctt ggc cgt atc tct gaa atc 403Ala Leu Val Met Gly Thr Ala Leu Gly Leu Gly Arg Ile Ser Glu Ile

90 95 100agg att ctc cgc tgg ttc tgc gcc gtc atc atc gag act ttc cga gcc 451Arg Ile Leu Arg Trp Phe Cys Ala Val Ile Ile Glu Thr Phe Arg Ala

105 110 115att ccg gtt ctg atc ctc atg att ttc gcc tac cag atg ttc gcc cag 499Ile Pro Val Leu Ile Leu Met Ile Phe Ala Tyr Gln Met Phe Ala Gln

120 125 130tac aac atc gtg ccg tcg agc cag ctc gcg ttc gcc gcc gtg gta ttc 547Tyr Asn Ile Val Pro Ser Ser Gln Leu Ala Phe Ala Ala Val Val Phe

135 140 145ggt ctg acc atg tac aac ggt tct gtg atc gca gag att ctg cgt tct 595Gly Leu Thr Met Tyr Asn Gly Ser Val Ile Ala Glu Ile Leu Arg Ser150 155 160 165ggt atc gct tcc ctg cct aag ggg cag aag gaa gca gcg att gcg ttg 643Gly Ile Ala Ser Leu Pro Lys Gly Gln Lys Glu Ala Ala Ile Ala Leu

170 175 180ggt atg tct tct agg caa acc acc tgg tca atc ttg ttg cct cag gcc 691Gly Met Ser Ser Arg Gln Thr Thr Trp Ser Ile Leu Leu Pro Gln Ala

185 190 195gtg gct gca atg ctc cca gcg ttg 715Val Ala Ala Met Leu Pro Ala Leu

200205<210>648<211>205<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>648Met Ala Asn Thr Val Arg Ala Thr Val Leu Tyr Asp Ala Pro Gly Pro 151015 Lys Gly Arg Arg Phe Asn Leu Ile Ile Thr Ile Leu Thr Val Val Leu

20 25 30Gly Leu Ala Leu Leu Phe Trp Ile Gly Ser Met Leu Ser Gly Asn Gly

35 40 45Gln Leu Asp Ala Asn Lys Trp Thr Pro Phe Ile Asn Ser Gln Thr Trp

50 55 60Thr Thr Tyr Ile Leu Pro Gly Leu Trp Gly Thr Leu Lys Ser Ala Val 65 70 75 80Phe Ser Val Ile Leu Ala Leu Val Met Gly Thr Ala Leu Gly Leu Gly

85 90 95Arg Ile Ser Glu Ile Arg Ile Leu Arg Trp Phe Cys Ala Val Ile Ile

100 105 110Glu Thr Phe Arg Ala Ile Pro Val Leu Ile Leu Met Ile Phe Ala Tyr

115 120 125Gln Met Phe Ala Gln Tyr Asn Ile Val Pro Ser Ser Gln Leu Ala Phe

130 135 140Ala Ala Val Val Phe Gly Leu Thr Met Tyr Asn Gly Ser Val Ile Ala145 150 155 160Glu Ile Leu Arg Ser Gly Ile Ala Ser Leu Pro Lys Gly Gln Lys Glu

165 170 175Ala Ala Ile Ala Leu Gly Met Ser Ser Arg Gln Thr Thr Trp Ser Ile

180 185 190Leu Leu Pro Gln Ala Val Ala Ala Met Leu Pro Ala Leu

195200205<210>649<211>245<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) } (222)<223>RXN02992<400>649atc gtc cct ttg ggc aac aca ctg atc gca ctg act aag aac acc acc 48Ile Val Pro Leu Gly Asn Thr Leu Ile Ala Leu Thr Lys Asn Thr Thr 151015 atc gcc tct gtc att gga gtt ggc gaa gcc tcc ctg ctg atg aaa gcc 96Ile Ala Ser Val Ile Gly Val Gly Glu Ala Ser Leu Leu Met Lys Ala

20 25 30acc atc gaa aat cac gcc aac atg cta ttt gtc gtg ttc gcg atc ttc 144Thr Ile Glu Asn His Ala Asn Met Leu Phe Val Val Phe Ala Ile Phe

354045 gcc gtt ggc ttc atg att ctg acc ctg cct atg ggc ctt ggc ttg ggc 192Ala Val Gly Phe Met Ile Leu Thr Leu Pro Met Gly Leu Gly Leu Gly 505560 aaa ctc tct gag cgt ttg gcg gtg aag aag taatggctaa tacagttcgc 242Lys Leu Ser Glu Arg Leu Ala Val Lys Lys 6570 gca 245<210>650<211>74<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>650Ile Val Pro Leu Gly Asn Thr Leu Ile Ala Leu Thr Lys Asn Thr Thr 151015 Ile Ala Ser Val Ile Gly Val Gly Glu Ala Ser Leu Leu Met Lys Ala

20 25 30Thr Ile Glu Asn His Ala Asn Met Leu Phe Val Val Phe Ala Ile Phe

35 40 45Ala Val Gly Phe Met Ile Leu Thr Leu Pro Met Gly Leu Gly Leu Gly

505560 Lys Leu Ser Glu Arg Leu Ala Val Lys Lys 6570<210>651<211>792<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (769)<223>RXN02996<400>651tcctgccaca gaatctgcct gctgctccat taactaaaaa ttgcaggcta gaatagaggg 60tcgattagga gtcgatgaaa aagtcggcgc caacgaggag atg aac aac aac gtg 115

Met Asn Asn Asn Val

1 5agt gat caa aag cta agt ggt aaa gag ctt gcg gca cta gag aaa caa 163Ser Asp Gln Lys Leu Ser Gly Lys Glu Leu Ala Ala Leu Glu Lys Gln

10 15 20gcc gca aaa act ctc gaa ctt ggt gat aag aag tgg tat ctc atc gcg 211Ala Ala Lys Thr Leu Glu Leu Gly Asp Lys Lys Trp Tyr Leu Ile Ala

25 30 35gga gtc gtg ctt ttc gcc atc gca ctc gtc ctc cca cat atc cgt gga 259Gly Val Val Leu Phe Ala Ile Ala Leu Val Leu Pro His Ile Arg Gly

40 45 50gtg atg ggc tgg cag gtt ctg acg ctg tcg aat gtc gcg gag gat gcc 307Val Met Gly Trp Gln Val Leu Thr Leu Ser Asn Val Ala Glu Asp Ala

55 60 65ggc att acc ctt ggt gag tac ggt ttc tac tgg ttg ggc acc atc ggt 355Gly Ile Thr Leu Gly Glu Tyr Gly Phe Tyr Trp Leu Gly Thr Ile Gly 70 75 80 85gta ttc ctg ctt tct ttg ggc act gtc gtg ttt aag cgc acg tgg atg 403Val Phe Leu Leu Ser Leu Gly Thr Val Val Phe Lys Arg Thr Trp Met

90 95 100gcg tgg att tca tgg att ttc tcc tgc gtc act ctt gtg ttc gct gtg 451Ala Trp Ile Ser Trp Ile Phe Ser Cys Val Thr Leu Val Phe Ala Val

105 110 115ttt gcc atc tgg atg cgc caa aca acc acc agc acc caa gtg aat ttc 499Phe Ala Ile Trp Met Arg Gln Thr Thr Thr Ser Thr Gln Val Asn Phe

120 125 130gtc aac att ggc atg atg ctt gct gtg att gca gcg atc ctt gct gtg 547Val Asn Ile Gly Met Met Leu Ala Val Ile Ala Ala Ile Leu Ala Val

135 140 145tgg ggt cta tct tcg gtg att ttg gcc cgc agt gat cgc caa atg gag 595Trp Gly Leu Ser Ser Val Ile Leu Ala Arg Ser Asp Arg Gln Met Glu150 155 160 165atc gct gaa atg cgc gcc gag aac cca gac ctt gat ggt gtt gca gct 643Ile Ala Glu Met Arg Ala Glu Asn Pro Asp Leu Asp Gly Val Ala Ala

170 175 180acc cag cgc gca ctt ctt gag cag cag caa agc aac cca gaa gat aat 691Thr Gln Arg Ala Leu Leu Glu Gln Gln Gln Ser Asn Pro Glu Asp Asn

185 190 195cct ttg ctt gtc gac gat cgt cgc gcc cgc atc gcc cgc cgc cgc gag 739Pro Leu Leu Val Asp Asp Arg Arg Ala Arg Ile Ala Arg Arg Arg Glu

200 205 210cgt gaa cag gat gca caa ggg gag cag gct taagttctag ttcaagcggt 789Arg Glu Gln Asp Ala Gln Gly Glu Gln Ala

215220 tga 792<210>652<211>223<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>652Met Asn Asn Asn Val Ser Asp Gln Lys Leu Ser Gly Lys Glu Leu Ala 151015 Ala Leu Glu Lys Gln Ala Ala Lys Thr Leu Glu Leu Gly Asp Lys Lys

20 25 30Trp Tyr Leu Ile Ala Gly Val Val Leu Phe Ala Ile Ala Leu Val Leu

35 40 45Pro His Ile Arg Gly Val Met Gly Trp Gln Val Leu Thr Leu Ser Asn

50 55 60Val Ala Glu Asp Ala Gly Ile Thr Leu Gly Glu Tyr Gly Phe Tyr Trp 65 70 75 80Leu Gly Thr Ile Gly Val Phe Leu Leu Ser Leu Gly Thr Val Val Phe

85 90 95Lys Arg Thr Trp Met Ala Trp Ile Ser Trp Ile Phe Ser Cys Val Thr

100105 110Leu Val Phe Ala Val Phe Ala Ile Trp Met Arg Gln Thr Thr Thr Ser

115 120 125Thr Gln Val Asn Phe Val Asn Ile Gly Met Met Leu Ala Val Ile Ala

130 135 140Ala Ile Leu Ala Val Trp Gly Leu Ser Ser Val Ile Leu Ala Arg Ser145 150 155 160Asp Arg Gln Met Glu Ile Ala Glu Met Arg Ala Glu Asn Pro Asp Leu

165 170 175Asp Gly Val Ala Ala Thr Gln Arg Ala Leu Leu Glu Gln Gln Gln Ser

180 185 190Asn Pro Glu Asp Asn Pro Leu Leu Val Asp Asp Arg Arg Ala Arg Ile

195 200 205Ala Arg Arg Arg Glu Arg Glu Gln Asp Ala Gln Gly Glu Gln Ala

210215220<210>653<211>1017<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (994)<223>RXN03126<400>653tcttggacaa cattacccca cacacgggac actcaaacgt gcatgaattc acctgtcgtc 60gatacccaaa aatcactcca ccaccactag ggtgtcttat gtg cag gaa caa tcg 115

Val Gln Glu Gln Ser

1 5aag cag aaa gac ctc cag gct gat atc gcc aga atc act gcc gtg aaa 163Lys Gln Lys Asp Leu Gln Ala Asp Ile Ala Arg Ile Thr Ala Val Lys

10 15 20tcg gac aca gtt ccg aat tcc cag tca atg acc ttt ggc gct gcc tgg 211Ser Asp Thr Val Pro Asn Ser Gln Ser Met Thr Phe Gly Ala Ala Trp

25 30 35aac gat atc gtc cgc gga ttc aag caa cat gag ttg tgg ctg caa ctc 259Asn Asp Ile Val Arg Gly Phe Lys Gln His Glu Leu Trp Leu Gln Leu

40 45 50ggc tgg caa gac att aag caa cgc tac cgg cga tcc gtc ctt ggg ccc 307Gly Trp Gln Asp Ile Lys Gln Arg Tyr Arg Arg Ser Val Leu Gly Pro

55 60 65ctg tgg atc acc atc gcc acc ggt gtc atg gcg ctc gcc ctc ggc ttg 355Leu Trp Ile Thr Ile Ala Thr Gly Val Met Ala Leu Ala Leu Gly Leu 70 75 80 85ctg tac tcc gtg ctg ttc aaa atc ccc atc gcg gaa ttt ctg ccc cac 403Leu Tyr Ser Val Leu Phe Lys Ile Pro Ile Ala Glu Phe Leu Pro His

90 95 100gtc acc gtc ggc ctg atc att tgg aac ttc atc tcc gga tgc atc aaa 451Val Thr Val Gly Leu Ile Ile Trp Asn Phe Ile Ser Gly Cys Ile Lys

105 110 115gaa ggc tcc gac atc ttc ata gat aac gag gga ctc atc aaa cag ctc 499Glu Gly Ser Asp Ile Phe Ile Asp Asn Glu Gly Leu Ile Lys Gln Leu

120 125 130ccc tcg gcg ctg tcc gtc cac gtg tac aga ctc gtg tgg aaa caa gcc 547Pro Ser Ala Leu Ser Val His Val Tyr Arg Leu Val Trp Lys Gln Ala

135 140 145ctc ttc ctc gcc cac aac ctg gtc atc tgg gtc att ctc atg atg atc 595Leu Phe Leu Ala His Asn Leu Val Ile Trp Val Ile Leu Met Met Ile150 155 160 165ttc ccc cga ccc ctc ggc tgg gac gtc ctc ctg atc atc ccc gca atg 643Phe Pro Arg Pro Leu Gly Trp Asp Val Leu Leu Ile Ile Pro Ala Met

170 175 180ttc ctc ctg gtg atc aac ggc gtg tgg gta gtc atg ttc ttc ggc atc 691Phe Leu Leu Val Ile Asn Gly Val Trp Val Val Met Phe Phe Gly Ile

185 190 195atc gcc acc cgc tac cgc gac gtc tcc ccg ttg cta gaa gcc gga acc 739Ile Ala Thr Arg Tyr Arg Asp Val Ser Pro Leu Leu Glu Ala Gly Thr

200 205 210caa ctc ctc ttc tac gtc acc ccc atc gtc tgg atg act tcc acc ctg 787Gln Leu Leu Phe Tyr Val Thr Pro Ile Val Trp Met Thr Ser Thr Leu

215 220 225caa tcc cag agc gca gaa atc ggc aac cgc gca cgc ctc gcc gaa ctc 835Gln Ser Gln Ser Ala Glu Ile Gly Asn Arg Ala Arg Leu Ala Glu Leu230 235 240 245aac ccg ctc tac cac tac ctc gaa att gtc cgc gcc ccc atg gtc ggc 883Asn Pro Leu Tyr His Tyr Leu Glu Ile Val Arg Ala Pro Met Val Gly

250 255 260gcc gac ctc ccc gcc tac cac tgg tgg atc gtc ctc gcc ttc aca ttc 931Ala Asp Leu Pro Ala Tyr His Trp Trp Ile Val Leu Ala Phe Thr Phe

265 270 275gtc ggc ctt ggc ctt gct ctc ctc gcg atg aag caa tgg cga ttc cgc 979Val Gly Leu Gly Leu Ala Leu Leu Ala Met Lys Gln Trp Arg Phe Arg

280 285 290gtc agc tac tgg gta taaggagcac cacatggtat cca 1017Val Ser Tyr Trp Val

295<210>654<211>298<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>654Val Gln Glu Gln Ser Lys Gln Lys Asp Leu Gln Ala Asp Ile Ala Arg 151015 Ile Thr Ala Val Lys Ser Asp Thr Val Pro Asn Ser Gln Ser Met Thr

20 25 30Phe Gly Ala Ala Trp Asn Asp Ile Val Arg Gly Phe Lys Gln His Glu

35 40 45Leu Trp Leu Gln Leu Gly Trp Gln Asp Ile LysGln Arg Tyr Arg Arg

50 55 60Ser Val Leu Gly Pro Leu Trp Ile Thr Ile Ala Thr Gly Val Met Ala 65 70 75 80Leu Ala Leu Gly Leu Leu Tyr Ser Val Leu Phe Lys Ile Pro Ile Ala

85 90 95Glu Phe Leu Pro His Val Thr Val Gly Leu Ile Ile Trp Asn Phe Ile

100 105 110Ser Gly Cys Ile Lys Glu Gly Ser Asp Ile Phe Ile Asp Asn Glu Gly

115 120 125Leu Ile Lys Gln Leu Pro Ser Ala Leu Ser Val His Val Tyr Arg Leu

130 135 140Val Trp Lys Gln Ala Leu Phe Leu Ala His Asn Leu Val Ile Trp Val145 150 155 160Ile Leu Met Met Ile Phe Pro Arg Pro Leu Gly Trp Asp Val Leu Leu

165 170 175Ile Ile Pro Ala Met Phe Leu Leu Val Ile Asn Gly Val Trp Val Val

180 185 190Met Phe Phe Gly Ile Ile Ala Thr Arg Tyr Arg Asp Val Ser Pro Leu

195 200 205Leu Glu Ala Gly Thr Gln Leu Leu Phe Tyr Val Thr Pro Ile Val Trp

210 215 220Met Thr Ser Thr Leu Gln Ser Gln Ser Ala Glu Ile Gly Asn Arg Ala225 230 235 240Arg Leu Ala Glu Leu Asn Pro Leu Tyr His Tyr Leu Glu Ile Val Arg

245 250 255Ala Pro Met Val Gly Ala Asp Leu Pro Ala Tyr His Trp Trp Ile Val

260 265 270Leu Ala Phe Thr Phe Val Gly Leu GlyLeu Ala Leu Leu Ala Met Lys

275 280 285Gln Trp Arg Phe Arg Val Ser Tyr Trp Val

290295<210>655<211>927<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (904)<223>RXN00443<400>655taaacaagga gcgtttaatt tccacccaat cccactgaaa gtttcccacc ccacagttat 60gctgattaag tactgaactt accgtaggaa aggcactcag gtg aac aaa agt atc 115

Val Asn Lys Ser Ile

1 5cgt cga gct ctc tac agt ttc atc act att tcg gcg ggt atc tca ctc 163Arg Arg Ala Leu Tyr Ser Phe Ile Thr Ile Ser Ala Gly Ile Ser Leu

10 15 20gta gcg tgc tct tct tca gac acc gca agc act acc acc cag aat gcc 211Val Ala Cys Ser Ser Ser Asp Thr Ala Ser Thr Thr Thr Gln Asn Ala

25 30 35tct gct acc gaa gca gct ggg gtt tcc gga acc gct agc gtt ttc gct 259Ser Ala Thr Glu Ala Ala Gly Val Ser Gly Thr Ala Ser Val Phe Ala

40 45 50gcg gcg tct ttg acc aac gtt gct gag gat ctc gcg gct gcg ttc aac 307Ala Ala Ser Leu Thr Asn Val Ala Glu Asp Leu Ala Ala Ala Phe Asn

55 60 65gaa gac aat cct gat gca aag ttg gag ttt aac ttc gct ggt tct tcc 355Glu Asp Asn Pro Asp Ala Lys Leu Glu Phe Asn Phe Ala Gly Ser Ser 70 75 80 85gcg ctg gtt cgc cag atc agc gaa ggc gca cca tct gat ctg ttc att 403Ala Leu Val Arg Gln Ile Ser Glu Gly Ala Pro Ser Asp Leu Phe Ile

90 95 100tct gcg gac atc gcc aac atg gac gat gcg ctg gca ctt cca gaa ttt 451Ser Ala Asp Ile Ala Asn Met Asp Asp Ala Leu Ala Leu Pro Glu Phe

105 110 115gcc ggc gca acc tcg aag gtc atc gct acc aac aag ctg gtg ctg gtc 499Ala Gly Ala Thr Ser Lys Val Ile Ala Thr Asn Lys Leu Val Leu Val

120 125 130acc gca gac ggc aac ccc ggc gaa att tca gag ctt gcc gac gtc aag 547Thr Ala Asp Gly Asn Pro Gly Glu Ile Ser Glu Leu Ala Asp Val Lys

135 140 145gac tcc ctc gtt gct atc tgc gcc cct gaa gtt cca tgt gga acc atc 595Asp Ser Leu Val Ala Ile Cys Ala Pro Glu Val Pro Cys Gly Thr Ile150 155 160 165acc cac gag gct ttg gac tac gca gac atc gag ttg aac acc agc tct 643Thr His Glu Ala Leu Asp Tyr Ala Asp Ile Glu Leu Asn Thr Ser Ser

170 175 180gag gaa gcc aat gtt gct gat gtc gcc acg aag att tcc acc ggt gca 691Glu Glu Ala Asn Val Ala Asp Val Ala Thr Lys Ile Ser Thr Gly Ala

185 190 195gtt gat gcg ggc ttt gtt tac caa acc gac gct cag tct ttg gct aaa 739Val Asp Ala Gly Phe Val Tyr Gln Thr Asp Ala Gln Ser Leu Ala Lys

200 205 210act cag gac aac act gtc att gaa ctc gaa ggt atc gac gcc aac gaa 787Thr Gln Asp Asn Thr Val Ile Glu Leu Glu Gly Ile Asp Ala Asn Glu

215 220 225tac cca atg gca ttg acc acc acc ggt gaa gac aac gag gta gcg aag 835Tyr Pro Met Ala Leu Thr Thr Thr Gly Glu Asp Asn Glu Val Ala Lys230 235 240 245gct ttc gca gag ttc ctc agc agc gat cgt gcc aag gag atc ctt gcc 883Ala Phe Ala Glu Phe Leu Ser Ser AspArg Ala Lys Glu Ile Leu Ala

250 255 260agc tat ggt ttt ggc aca aac taaaaaggct cgtcgaagcg aga 927Ser Tyr Gly Phe Gly Thr Asn

265<210>656<211>268<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>656Val Asn Lys Ser Ile Arg Arg Ala Leu Tyr Ser Phe Ile Thr Ile Ser 151015 Ala Gly Ile Ser Leu Val Ala Cys Ser Ser Ser Asp Thr Ala Ser Thr

20 25 30Thr Thr Gln Asn Ala Ser Ala Thr Glu Ala Ala Gly Val Ser Gly Thr

35 40 45Ala Ser Val Phe Ala Ala Ala Ser Leu Thr Asn Val Ala Glu Asp Leu

50 55 60Ala Ala Ala Phe Asn Glu Asp Asn Pro Asp Ala Lys Leu Glu Phe Asn 65 70 75 80Phe Ala Gly Ser Ser Ala Leu Val Arg Gln Ile Ser Glu Gly Ala Pro

85 90 95Ser Asp Leu Phe Ile Ser Ala Asp Ile Ala Asn Met Asp Asp Ala Leu

100 105 110Ala Leu Pro Glu Phe Ala Gly Ala Thr Ser Lys Val Ile Ala Thr Asn

115 120 125Lys Leu Val Leu Val Thr Ala Asp Gly Asn Pro Gly Glu Ile Ser Glu

130 135 140Leu Ala Asp Val Lys Asp Ser Leu Val Ala Ile Cys Ala Pro Glu Val145 150 155 160Pro Cys Gly Thr Ile Thr His Glu Ala Leu Asp Tyr Ala Asp Ile Glu

165 170 175Leu Asn Thr Ser Ser Glu Glu Ala Asn Val Ala Asp Val Ala Thr Lys

180 185190Ile Ser Thr Gly Ala Val Asp Ala Gly Phe Val Tyr Gln Thr Asp Ala

195 200 205Gln Ser Leu Ala Lys Thr Gln Asp Asn Thr Val Ile Glu Leu Glu Gly

210 215 220Ile Asp Ala Asn Glu Tyr Pro Met Ala Leu Thr Thr Thr Gly Glu Asp225 230 235 240Asn Glu Val Ala Lys Ala Phe Ala Glu Phe Leu Ser Ser Asp Arg Ala

245 250 255Lys Glu Ile Leu Ala Ser Tyr Gly Phe Gly Thr Asn

260265<210>657<211>960<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (937)<223>RXN00444<400>657tacccaatgg cattgaccac caccggtgaa gacaacgagg tagcgaaggc tttcgcagag 60ttcctcagca gcgatcgtgc caaggagatc cttgccagct atg gtt ttg gca caa 115

Met Val Leu Ala Gln

1 5act aaa aag gct cgt cga agc gag aat cat atc ctc cca ggg tgg ttg 163Thr Lys Lys Ala Arg Arg Ser Glu Asn His Ile Leu Pro Gly Trp Leu

10 15 20ctc atc cca gcc acc ctg gcc atg ctg ctg atc att gga cct att ttt 211Leu Ile Pro Ala Thr Leu Ala Met Leu Leu Ile Ile Gly Pro Ile Phe

25 30 35gct ttg ctg ttg cag atc ccc tgg gat cgg tct tgg gag ttg ctt acc 259Ala Leu Leu Leu Gln Ile Pro Trp Asp Arg Ser Trp Glu Leu Leu Thr

40 45 50gcg ccg gaa tct tta gga acc gca cgg tta tct atc gga act gct ctg 307Ala Pro Glu Ser Leu Gly Thr Ala Arg Leu Ser Ile Gly Thr Ala Leu

55 60 65ttt tct acc gcg cta tgc gca att gtg ggt ttc ccg cta gcg ttg gcg 355Phe Ser Thr Ala Leu Cys Ala Ile Val Gly Phe Pro Leu Ala Leu Ala 70 75 80 85ctg cat tta tat gag cgt tcg cac ccc agg gtg aca tca gtt ttg acg 403Leu His Leu Tyr Glu Arg Ser His Pro Arg Val Thr Ser Val Leu Thr

90 95 100gtg ctg gtt tat gcg cct ttg gtg ttg tcg ccg gtg gtg tct ggt ttg 451Val Leu Val Tyr Ala Pro Leu Val Leu Ser Pro Val Val Ser Gly Leu

105 110 115gcg ctg act ttt ctg tgg ggc agg cgt ggt ttt tta ggt tct tgg ctt 499Ala Leu Thr Phe Leu Trp Gly Arg Arg Gly Phe Leu Gly Ser Trp Leu

120 125 130gat cag gtt gga ttg ccg att gca ttt acc acc acg gct gtg gtg ttt 547Asp Gln Val Gly Leu Pro Ile Ala Phe Thr Thr Thr Ala Val Val Phe

135 140 145gcc cag gtg ttt gta gcg ttg cca ttt ttc att tcc act gtg act act 595Ala Gln Val Phe Val Ala Leu Pro Phe Phe Ile Ser Thr Val Thr Thr150 155 160 165gca ctg cgt ggc att cca aaa cag ttt gag gaa atc gca gct act gaa 643Ala Leu Arg Gly Ile Pro Lys Gln Phe Glu Glu Ile Ala Ala Thr Glu

170 175 180ggc gca acc cgc tgg gag atc atg cac aag atg atc att ccg ctg gcg 691Gly Ala Thr Arg Trp Glu Ile Met His Lys Met Ile Ile Pro Leu Ala

185 190 195atg cct gga att ttc acc ggt atg att ttg gga ttc gcc agg gcc ttg 739Met Pro Gly Ile Phe Thr Gly Met Ile Leu Gly Phe Ala Arg Ala Leu

200 205 210ggc gag tat ggt gcg aca ctg act ttt gct gga aat att gca ggt gtt 787Gly Glu Tyr Gly Ala Thr Leu Thr Phe Ala Gly Asn Ile Ala Gly Val

215 220 225acc cgc acc att ccg ttg cat att gag ctt ggt ttg agt tcc aat gac 835Thr Arg Thr Ile Pro Leu His Ile Glu Leu Gly Leu Ser Ser Asn Asp230 235 240 245atg gat aaa gcc ttg gga gcg gtg att atg ctt ttg gct gtc tat gtc 883Met Asp Lys Ala Leu Gly Ala Val Ile Met Leu Leu Ala Val Tyr Val

250 255 260ctc atc att gga gcc atc gga gcg tta cga ttg ttt tcc aag gtg aga 931Leu Ile Ile Gly Ala Ile Gly Ala Leu Arg Leu Phe Ser Lys Val Arg

265270275 aag gtt taattgatgt ctcgttcgcc gga 960Lys Val<210>658<211>279<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>658Met Val Leu Ala Gln Thr Lys Lys Ala Arg Arg Ser Glu Asn His Ile 151015 Leu Pro Gly Trp Leu Leu Ile Pro Ala Thr Leu Ala Met Leu Leu Ile

20 25 30Ile Gly Pro Ile Phe Ala Leu Leu Leu Gln Ile Pro Trp Asp Arg Ser

35 40 45Trp Glu Leu Leu Thr Ala Pro Glu Ser Leu Gly Thr Ala Arg Leu Ser

50 55 60Ile Gly Thr Ala Leu Phe Ser Thr Ala Leu Cys Ala Ile Val Gly Phe 65 70 75 80Pro Leu Ala Leu Ala Leu His Leu Tyr Glu Arg Ser His Pro Arg Val

85 90 95Thr Ser Val Leu Thr Val Leu Val Tyr Ala Pro Leu Val Leu Ser Pro

100 105 110Val Val Ser Gly Leu Ala Leu Thr Phe Leu Trp Gly Arg Arg Gly Phe

115120 125Leu Gly Ser Trp Leu Asp Gln Val Gly Leu Pro Ile Ala Phe Thr Thr

130 135 140Thr Ala Val Val Phe Ala Gln Val Phe Val Ala Leu Pro Phe Phe Ile145 150 155 160Ser Thr Val Thr Thr Ala Leu Arg Gly Ile Pro Lys Gln Phe Glu Glu

165 170 175Ile Ala Ala Thr Glu Gly Ala Thr Arg Trp Glu Ile Met His Lys Met

180 185 190Ile Ile Pro Leu Ala Met Pro Gly Ile Phe Thr Gly Met Ile Leu Gly

195 200 205Phe Ala Arg Ala Leu Gly Glu Tyr Gly Ala Thr Leu Thr Phe Ala Gly

210 215 220Asn Ile Ala Gly Val Thr Arg Thr Ile Pro Leu His Ile Glu Leu Gly225 230 235 240Leu Ser Ser Asn Asp Met Asp Lys Ala Leu Gly Ala Val Ile Met Leu

245 250 255Leu Ala Val Tyr Val Leu Ile Ile Gly Ala Ile Gly Ala Leu Arg Leu

260 265 270Phe Ser Lys Val Arg Lys Val

275<210>659<211>594<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(1) }, (594)<223>RXN00193<220><221>misc _ defect<222>11<223>n represents any of the nucleotides<220><221>variant<222>4<223>Xaa ═ Phe, Ser, Tyr or Cys<400>659aa gct ttc tnc caa cgc gaa ggt ttc atc tca gcc ttc ggt ttc acc 48Lys Ala Phe Xaa Gln Arg Glu Gly Phe Ile Ser Ala Phe Gly Phe Thr 151015 gtc ctc gtg gtc atc gtc tcc gtg atc aca gtc aac atc ttc gcc ttc 96Val Leu Val Val Ile Val Ser Val Ile ThrVal Asn Ile Phe Ala Phe

20 25 30ctc ttg gcg tgg ttg ctg acc cgc aaa ctc cgc ggt acc aac ttt ttc 144Leu Leu Ala Trp Leu Leu Thr Arg Lys Leu Arg Gly Thr Asn Phe Phe

35 40 45cgc aca gtc ttc ttt atg ccg aac ctt atc ggc ggc att gtg ctg ggt 192Arg Thr Val Phe Phe Met Pro Asn Leu Ile Gly Gly Ile Val Leu Gly

50 55 60tat acc tgg cag acc atg atc aac gcc gtg ctt tcg cac tat gcc acg 240Tyr Thr Trp Gln Thr Met Ile Asn Ala Val Leu Ser His Tyr Ala Thr 65 70 75 80act att agc gcg gac tgg aaa ttc ggc tac gcc ggc ctc atc atg cta 288Thr Ile Ser Ala Asp Trp Lys Phe Gly Tyr Ala Gly Leu Ile Met Leu

85 90 95ctt aac tgg cag ctc atc ggc tac atg atg atc att tac atc gcc ggc 336Leu Asn Trp Gln Leu Ile Gly Tyr Met Met Ile Ile Tyr Ile Ala Gly

100 105 110ctg caa aac gtc cca cca gag ctc att gag gct gcc gaa ctc gac ggc 384Leu Gln Asn Val Pro Pro Glu Leu Ile Glu Ala Ala Glu Leu Asp Gly

115 120 125gtc aac aag tgg gag atg ctg cgg cac gtc act att ccg atg gtc atg 432Val Asn Lys Trp Glu Met Leu Arg His Val Thr Ile Pro Met Val Met

130 135 140cca tcc atc acc atc tgc ctc ttt ttg act ttg tcg aac tcc ttt aag 480Pro Ser Ile Thr Ile Cys Leu Phe Leu Thr Leu Ser Asn Ser Phe Lys145 150 155 160ctc ttc gac cag aac ctg gcg ctg acc aac ggc gct cct ggc ggg caa 528Leu Phe Asp Gln Asn Leu Ala Leu Thr Asn Gly Ala Pro Gly Gly Gln

165 170175act gag atg gtg gcg ctc aac atc atc aac acg ctg ttt aac cgt atg 576Thr Glu Met Val Ala Leu Asn Ile Ile Asn Thr Leu Phe Asn Arg Met

180 185 190aat gtc gag ggc gtc ggt 594Asn Val Glu Gly Val Gly

195<210>660<211>198<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>variant<222>4<223>Xaa ═ Phe, Ser, Tyr or Cys<400>660Lys Ala Phe Xaa Gln Arg Glu Gly Phe Ile Ser Ala Phe Gly Phe Thr 151015 Val Leu Val Val Ile Val Ser Val Ile Thr Val Asn Ile Phe Ala Phe

20 25 30Leu Leu Ala Trp Leu Leu Thr Arg Lys Leu Arg Gly Thr Asn Phe Phe

35 40 45Arg Thr Val Phe Phe Met Pro Asn Leu Ile Gly Gly Ile Val Leu Gly

50 55 60Tyr Thr Trp Gln Thr Met Ile Asn Ala Val Leu Ser His Tyr Ala Thr 65 70 75 80Thr Ile Ser Ala Asp Trp Lys Phe Gly Tyr Ala Gly Leu Ile Met Leu

85 90 95Leu Asn Trp Gln Leu Ile Gly Tyr Met Met Ile Ile Tyr Ile Ala Gly

100 105 110Leu Gln Asn Val Pro Pro Glu Leu Ile Glu Ala Ala Glu Leu Asp Gly

115 120 125Val Asn Lys Trp Glu Met Leu Arg His Val Thr Ile Pro Met Val Met

130 135 140Pro Ser Ile Thr Ile Cys Leu Phe Leu Thr Leu Ser Asn Ser Phe Lys145 150 155 160Leu Phe Asp Gln Asn Leu Ala Leu Thr Asn Gly Ala Pro Gly Gly Gln

165 170 175Thr Glu Met Val Ala Leu Asn Ile Ile Asn Thr Leu Phe Asn Arg Met

180 185 190Asn Val Glu Gly Val Gly

195<210>661<211>1053<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1030)<223>RXN01298<400>661cttaaacgtc accttattta tgcattatgt tggtttcaga ctcgaacaat tcaattagaa 60aacactaatc ggacatttag gtcacataac atttccgctc gtg tcc aca tta att 115

Val Ser Thr Leu Ile

1 5tct gaa ccc gag gtg gat aag cta cgt aaa cgt gcc aag aga tca agg 163Ser Glu Pro Glu Val Asp Lys Leu Arg Lys Arg Ala Lys Arg Ser Arg

10 15 20cgg aca gaa tgg tgg ctt gcc gcc gca ctt ctt gcc cca aac ttg ctt 211Arg Thr Glu Trp Trp Leu Ala Ala Ala Leu Leu Ala Pro Asn Leu Leu

25 30 35ctc ttg gcc atc ttt acg tat cgg cca ctg tta gat aac ttc cgg ttg 259Leu Leu Ala Ile Phe Thr Tyr Arg Pro Leu Leu Asp Asn Phe Arg Leu

40 45 50tcc ttt ttc aac tgg aac att tcc tcg ccc aca tca acc ttc att ggg 307Ser Phe Phe Asn Trp Asn Ile Ser Ser Pro Thr Ser Thr Phe Ile Gly

55 60 65ttt gat aac tac gtt gag ttc ttc act cgt agt gac act ctc caa gtt 355Phe Asp Asn Tyr Val Glu Phe Phe Thr Arg Ser Asp Thr Leu Gln Val 70 75 80 85gtt tta aac acc gtc atc ttc acg gca tgt gct gtg atc gga tcg atg 403Val Leu Asn Thr Val Ile Phe Thr Ala Cys Ala Val Ile Gly Ser Met

90 95 100gtg ctc ggt ttg ctc ctg gcc atg ttg ttg gat cag aag ctt ttc ggc 451Val Leu Gly Leu Leu Leu Ala Met Leu Leu Asp Gln Lys Leu Phe Gly

105 110 115cgt aac ttt gtg cgt tcc atg gtg ttt gcc ccg ttt gtg att tcc ggt 499Arg Asn Phe Val Arg Ser Met Val Phe Ala Pro Phe Val Ile Ser Gly

120 125 130gct gcc att ggt gtt gct ttc cag ttc gtt ttt gac cct aat ttt ggt 547Ala Ala Ile Gly Val Ala Phe Gln Phe Val Phe Asp Pro Asn Phe Gly

135 140 145ttg gtt cag gac ttg ctg gga cgc atc ggc gtt gat tcg cca cag ttc 595Leu Val Gln Asp Leu Leu Gly Arg Ile Gly Val Asp Ser Pro Gln Phe150 155 160 165tac caa aac cct aac tgg gca ttg ttc atg gtg acg ttc act ttc gtg 643Tyr Gln Asn Pro Asn Trp Ala Leu Phe Met Val Thr Phe Thr Phe Val

170 175 180tgg aag aac ttg ggc tac tcc ttt gtt atc tac ctg gct gca ttg cag 691Trp Lys Asn Leu Gly Tyr Ser Phe Val Ile Tyr Leu Ala Ala Leu Gln

185 190 195ggg cta aac aag gat ttg tct gag gcc gca ccg gtg gat ggc gcg agc 739Gly Leu Asn Lys Asp Leu Ser Glu Ala Ala Pro Val Asp Gly Ala Ser

200 205 210gcg tgg aca cgt ttt tgg aag gtt act ctt ccg cag ctt cgc cca acc 787Ala Trp Thr Arg Phe Trp Lys Val Thr Leu Pro Gln Leu Arg Pro Thr

215 220 225acg ttc ttc ctt tct att act gtc acg ctg aac tcg gtt cag gtc ttc 835Thr Phe Phe Leu Ser Ile Thr Val Thr Leu Asn Ser Val Gln Val Phe230 235 240 245gac atc att cac acc atg act cgtggt ggc ccc ttg ggt aac ggt acg 883Asp Ile Ile His Thr Met Thr Arg Gly Gly Pro Leu Gly Asn Gly Thr

250 255 260acc acc ttg gtt tac cag gtg tac acc gag act ttc acc aac tat cgc 931Thr Thr Leu Val Tyr Gln Val Tyr Thr Glu Thr Phe Thr Asn Tyr Arg

265 270 275gcg gga tat ggt gca aca atc gca acg att ttg ttc ctg ttg ctg ctg 979Ala Gly Tyr Gly Ala Thr Ile Ala Thr Ile Leu Phe Leu Leu Leu Leu

280 285 290att atc act gtt atc cag gtt cga tac atg gat aag gag aac aag cag 1027Ile Ile Thr Val Ile Gln Val Arg Tyr Met Asp Lys Glu Asn Lys Gln

295300305 aaa tgatctcgac tgatagaaac gtt 1053Lys310<210>662<211>310<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>662Val Ser Thr Leu Ile Ser Glu Pro Glu Val Asp Lys Leu Arg Lys Arg 151015 Ala Lys Arg Ser Arg Arg Thr Glu Trp Trp Leu Ala Ala Ala Leu Leu

20 25 30Ala Pro Asn Leu Leu Leu Leu Ala Ile Phe Thr Tyr Arg Pro Leu Leu

35 40 45Asp Asn Phe Arg Leu Ser Phe Phe Asn Trp Asn Ile Ser Ser Pro Thr

50 55 60Ser Thr Phe Ile Gly Phe Asp Asn Tyr Val Glu Phe Phe Thr Arg Ser 65 70 75 80Asp Thr Leu Gln Val Val Leu Asn Thr Val Ile Phe Thr Ala Cys Ala

85 90 95Val Ile Gly Ser Met Val Leu Gly Leu Leu Leu Ala Met Leu Leu Asp

100 105 110Gln Lys Leu Phe Gly Arg Asn Phe Val Arg Ser Met Val Phe Ala Pro

115 120 125Phe Val Ile Ser Gly Ala Ala Ile Gly Val Ala Phe Gln Phe Val Phe

130 135 140Asp Pro Asn Phe Gly Leu Val Gln Asp Leu Leu Gly Arg Ile Gly Val145 150 155 160Asp Ser Pro Gln Phe Tyr Gln Asn Pro Asn Trp Ala Leu Phe Met Val

165 170 175Thr Phe Thr Phe Val Trp Lys Asn Leu Gly Tyr Ser Phe Val Ile Tyr

180 185 190Leu Ala Ala Leu Gln Gly Leu Asn Lys Asp Leu Ser Glu Ala Ala Pro

195 200 205Val Asp Gly Ala Ser Ala Trp Thr Arg Phe Trp Lys Val Thr Leu Pro

210 215 220Gln Leu Arg Pro Thr Thr Phe Phe Leu Ser Ile Thr Val Thr Leu Asn225 230 235 240Ser Val Gln Val Phe Asp Ile Ile His Thr Met Thr Arg Gly Gly Pro

245 250 255Leu Gly Asn Gly Thr Thr Thr Leu Val Tyr Gln Val Tyr Thr Glu Thr

260 265 270Phe Thr Asn Tyr Arg Ala Gly Tyr Gly Ala Thr Ile Ala Thr Ile Leu

275 280 285Phe Leu Leu Leu Leu Ile Ile Thr Val Ile Gln Val Arg Tyr Met Asp

290295300 Lys Glu Asn Lys Gln Lys 305310<210>663<211>1182<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1159)<223>RXA01737<400>663ctttgagccg aacgatctgc cgactcaaga agaactagcc cggctgctca gtcaggaatg 60atgcgcctaa gatcaaacaa gaatgaaagg acggtgaaca atg ggc cga atg aaa 115

Met Gly Arg Met Lys

1 5aac gat ggt gaa ctc gcg gat ctg ccg gat cat gca ctt ttg agc att 163Asn Asp Gly Glu Leu Ala Asp Leu Pro Asp His Ala Leu Leu Ser Ile

10 15 20att cga atc ccg cag gcg gcg aaa aga agc ccc tgg gcg ctg atc tta 211Ile Arg Ile Pro Gln Ala Ala Lys Arg Ser Pro Trp Ala Leu Ile Leu

25 30 35acg cgc atc gga tac gcg atg gtg ctg ctg gtt atc gtc acc atg gtt 259Thr Arg Ile Gly Tyr Ala Met Val Leu Leu Val Ile Val Thr Met Val

40 45 50gtc tat ttt gac cgc aac gga tac tcc gaa gac ctc acg ttc atc gac 307Val Tyr Phe Asp Arg Asn Gly Tyr Ser Glu Asp Leu Thr Phe Ile Asp

55 60 65gcg ttg tac tat tcc aca gtc tcg ttg acc acc gtg ggc tac ggc gat 355Ala Leu Tyr Tyr Ser Thr Val Ser Leu Thr Thr Val Gly Tyr Gly Asp 70 75 80 85atc acc ccg gtg acg caa tcg gca cgc ctg atc aac atc atc gtc ctc 403Ile Thr Pro Val Thr Gln Ser Ala Arg Leu Ile Asn Ile Ile Val Leu

90 95 100acc cca gca cgc atc ggc ttc ctg atc ctc ctg gtc ggc acc acc ttg 451Thr Pro Ala Arg Ile Gly Phe Leu Ile Leu Leu Val Gly Thr Thr Leu

105 110 115tca gtg ctc acc gaa gaa tcg cgc cgg gcc ctg caa atc caa cgt tgg 499Ser Val Leu Thr Glu Glu Ser Arg Arg Ala Leu Gln Ile Gln Arg Trp

120 125 130aga aaa cgc atg cgc aac cac acc gtc gtt gtc gga tac gga acc aaa 547Arg Lys Arg Met Arg Asn His Thr Val Val Val Gly Tyr GlyThr Lys

135 140 145ggt cgc tcc gcg gtc gct gca ctg ctt ggc gac ggc gtc ccc gcc aac 595Gly Arg Ser Ala Val Ala Ala Leu Leu Gly Asp Gly Val Pro Ala Asn150 155 160 165cag atc gtt gtt atc gac acc gat caa gtc tcc ctc gac gcc gcc aac 643Gln Ile Val Val Ile Asp Thr Asp Gln Val Ser Leu Asp Ala Ala Asn

170 175 180aac agc gga ctc gtc acc gtc aaa ggc tcc gcc acc aaa gca gat gtg 691Asn Ser Gly Leu Val Thr Val Lys Gly Ser Ala Thr Lys Ala Asp Val

185 190 195ttg cgt cta gct ggc gtg tca cga gcg cgc gcc gtc gtc gtg gca ccg 739Leu Arg Leu Ala Gly Val Ser Arg Ala Arg Ala Val Val Val Ala Pro

200 205 210aac ctg gac gat act gca gtt ctg gtg act cta tcg gtg cga gaa atc 787Asn Leu Asp Asp Thr Ala Val Leu Val Thr Leu Ser Val Arg Glu Ile

215 220 225gcg ccg cag gca atg att gtg gcc agt gtc cga gaa tct gaa aac caa 835Ala Pro Gln Ala Met Ile Val Ala Ser Val Arg Glu Ser Glu Asn Gln230 235 240 245cac ctc ctc gaa caa tcc ggt gcg gac tcg gtt gtg atc tcc tca gaa 883His Leu Leu Glu Gln Ser Gly Ala Asp Ser Val Val Ile Ser Ser Glu

250 255 260acc gct ggc cga atg ctc ggt ctg gca aca gtt acc cca tcg gtt gtg 931Thr Ala Gly Arg Met Leu Gly Leu Ala Thr Val Thr Pro Ser Val Val

265 270 275gag atg atg gaa gac ctc ctc tca ccc gac gaa gga ttc tcc gtt gcc 979Glu Met Met Glu Asp Leu Leu Ser Pro Asp Glu Gly Phe Ser Val Ala

280 285 290gaa cga cta gtc ggt gag gat gaa atc ggc tcc aac cca cga cac ctc 1027Glu Arg Leu Val Gly Glu Asp Glu Ile Gly Ser Asn Pro Arg His Leu

295 300 305gct gac atc gtc ctc ggt gtt gtt cga tcc ggt gag ctc tac cgc atc 1075Ala Asp Ile Val Leu Gly Val Val Arg Ser Gly Glu Leu Tyr Arg Ile310 315 320 325gac tcc cca gaa gca gaa act gta gag ccc ggc gat cgt ctc ctt tac 1123Asp Ser Pro Glu Ala Glu Thr Val Glu Pro Gly Asp Arg Leu Leu Tyr

330 335 340gtt cgc cga gta ttt agc gag gag gta aat gac aaa tgagaattct 1169Val Arg Arg Val Phe Ser Glu Glu Val Asn Asp Lys

345350 tcccatcggc ccc 1182<210>664<211>353<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>664Met Gly Arg Met Lys Asn Asp Gly Glu Leu Ala Asp Leu Pro Asp His 151015 Ala Leu Leu Ser Ile Ile Arg Ile Pro Gln Ala Ala Lys Arg Ser Pro

20 25 30Trp Ala Leu Ile Leu Thr Arg Ile Gly Tyr Ala Met Val Leu Leu Val

35 40 45Ile Val Thr Met Val Val Tyr Phe Asp Arg Asn Gly Tyr Ser Glu Asp

50 55 60Leu Thr Phe Ile Asp Ala Leu Tyr Tyr Ser Thr Val Ser Leu Thr Thr 65 70 75 80Val Gly Tyr Gly Asp Ile Thr Pro Val Thr Gln Ser Ala Arg Leu Ile

85 90 95Asn Ile Ile Val Leu Thr Pro Ala Arg Ile Gly Phe Leu Ile Leu Leu

100 105 110Val Gly Thr Thr Leu Ser Val Leu Thr Glu Glu Ser Arg Arg Ala Leu

115 120 125Gln Ile Gln Arg Trp Arg Lys Arg Met Arg Asn His Thr Val Val Val

130 135 140Gly Tyr Gly Thr Lys Gly Arg Ser Ala Val Ala Ala Leu Leu Gly Asp145 150 155 160Gly Val Pro Ala Asn Gln Ile Val Val Ile Asp Thr Asp Gln Val Ser

165 170 175Leu Asp Ala Ala Asn Asn Ser Gly Leu Val Thr Val Lys Gly Ser Ala

180 185 190Thr Lys Ala Asp Val Leu Arg Leu Ala Gly Val Ser Arg Ala Arg Ala

195 200 205Val Val Val Ala Pro Asn Leu Asp Asp Thr Ala Val Leu Val Thr Leu

210 215 220Ser Val Arg Glu Ile Ala Pro Gln Ala Met Ile Val Ala Ser Val Arg225 230 235 240Glu Ser Glu Asn Gln His Leu Leu Glu Gln Ser Gly Ala Asp Ser Val

245 250 255Val Ile Ser Ser Glu Thr Ala Gly Arg Met Leu Gly Leu Ala Thr Val

260 265 270Thr Pro Ser Val Val Glu Met Met Glu Asp Leu Leu Ser Pro Asp Glu

275 280 285Gly Phe Ser Val Ala Glu Arg Leu Val Gly Glu Asp Glu Ile Gly Ser

290 295 300Asn Pro Arg His Leu Ala Asp Ile Val Leu Gly Val Val Arg Ser Gly305 310 315 320Glu Leu Tyr Arg Ile Asp Ser Pro Glu Ala Glu Thr Val Glu Pro Gly

325 330 335Asp Arg Leu Leu Tyr Val Arg Arg Val Phe Ser Glu Glu Val Asn Asp

340345350 Lys<210>665<211>2007<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1984)<223>RXN02348<400>665aaagacccga gccgaagccc tggcctgcgc atacttcctt gtcaacgctc gctgggatta 60ggtcttttct gagcgctagc atttctccac tcaaaggagc atg ctt aac cgc atg 115

Met Leu Asn Arg Met

1 5aaa agt gcg cgg cca aaa tca gtc gct cca aaa tcc gga caa gct tta 163Lys Ser Ala Arg Pro Lys Ser Val Ala Pro Lys Ser Gly Gln Ala Leu

10 15 20ctc act ctc ggt gcc cta ggt gtt gtg ttc ggc gac atc ggc acc agc 211Leu Thr Leu Gly Ala Leu Gly Val Val Phe Gly Asp Ile Gly Thr Ser

25 30 35ccc ctg tac tca ctt cac act gca ttc agc atg cag cac aac aaa gtc 259Pro Leu Tyr Ser Leu His Thr Ala Phe Ser Met Gln His Asn Lys Val

40 45 50gaa gtc act cag gaa aat gtg tac ggc atc atc tcc atg gtg ttg tgg 307Glu Val Thr Gln Glu Asn Val Tyr Gly Ile Ile Ser Met Val Leu Trp

55 60 65acc atc act ttg atc gtc acc gtc aaa tac gtc atg ctg gtc acc cga 355Thr Ile Thr Leu Ile Val Thr Val Lys Tyr Val Met Leu Val Thr Arg 70 75 80 85gct gac aac caa gga caa ggt ggc atc ctg gcg ctc gtt gct ttg ctg 403Ala Asp Asn Gln Gly Gln Gly Gly Ile Leu Ala Leu Val Ala Leu Leu

90 95 100aaa aac cgt ggg cac tgg gga aaa ttc gtg gca gta gcc ggc atg ttg 451Lys Asn Arg Gly His Trp Gly Lys Phe Val Ala Val Ala Gly Met Leu

105 110 115ggc gcc gca ttg ttt tat ggc gat gtg gtg atc acc ccg gcg atc tct 499Gly Ala Ala Leu Phe Tyr Gly Asp Val Val Ile Thr Pro Ala Ile Ser

120 125 130gtt ctc agc gca aca gaa ggc ttg acg gtt atc tcc cca agc ttt gag 547Val Leu Ser Ala Thr Glu Gly Leu Thr Val Ile Ser Pro Ser Phe Glu

135 140 145cgc ttc att crg ccc gta tct ctc gca gtt ctg atc gct att ttt gca 595Arg Phe Ile Leu Pro Val Ser Leu Ala Val Leu Ile Ala Ile Phe Ala150 155 160 165atc caa ccg ctc ggt aca gaa aaa gtc ggc aaa gcc ttc ggc ccc atc 643Ile Gln Pro Leu Gly Thr Glu Lys Val Gly Lys Ala Phe Gly Pro Ile

170 175 180atg ttg ctg tgg ttt gtc acc ctt gca gga ttg gga att ccg caa atc 691Met Leu Leu Trp Phe Val Thr Leu Ala Gly Leu Gly Ile Pro Gln Ile

185 190 195atc ggg cac cca gaa atc ttg cag agc ttg tct cca cat tgg gcc ctg 739Ile Gly His Pro Glu Ile Leu Gln Ser Leu Ser Pro His Trp Ala Leu

200 205 210cgc ttg att gtg gct gag cct ttc caa gca ttt gtg ctg ctt ggt gcc 787Arg Leu Ile Val Ala Glu Pro Phe Gln Ala Phe Val Leu Leu Gly Ala

215 220 225gtt gtc ctg aca gta acg ggt gcg gaa gcg ctc tac gct gat atg ggc 835Val Val Leu Thr Val Thr Gly Ala Glu Ala Leu Tyr Ala Asp Met Gly230 235 240 245cat ttt ggg gcg agg cca atc aga gtg gcg tgg ttt tgc gtc gtc atg 883His Phe Gly Ala Arg Pro Ile Arg Val Ala Trp Phe Cys Val Val Met

250 255 260cct gct tta atc ttg acg tat ttg ggg cag ggc gcc ttg gtg atc aac 931Pro Ala Leu Ile Leu Thr Tyr Leu Gly Gln Gly Ala Leu Val Ile Asn

265 270 275cag cct gaa gcg gtg cgc aac ccc atg ttt tat ctc gcg ccg gaa ggt 979Gln Pro Glu Ala Val Arg Asn Pro Met Phe Tyr Leu Ala Pro Glu Gly

280 285 290ctg cgg att ccg ttg gtt att ttg gcg acc atc gct acg gtg atc gca 1027Leu Arg Ile Pro Leu Val Ile Leu Ala Thr Ile Ala Thr Val Ile Ala

295 300 305tcg cag gcc gtg att tct ggt gcg tat tca ttg acc aag cag gcc gtg 1075Ser Gln Ala Val Ile Ser Gly Ala Tyr Ser Leu Thr Lys Gln Ala Val310 315 320 325aat ttg aaa ctg ctg cca cgc atg gtg atc cgg cat acc tcc cgc aaa 1123Asn Leu Lys Leu Leu Pro Arg Met Val Ile Arg His Thr Ser Arg Lys

330 335 340gag gaa ggc cag atc tat atg cca ctg gtt aat gga ttg ctg ttt gta 1171Glu Glu Gly Gln Ile Tyr Met Pro Leu Val Asn Gly Leu Leu Phe Val

345 350 355tcc gtg atg gtt gtg gtg ctg gta ttc cga tcc tct gaa agc ctc gcc 1219Ser Val Met Val Val Val Leu Val Phe Arg Ser Ser Glu Ser Leu Ala

360 365 370agc gcg tac gga ctt gca gtg acc gga acc ttg gtg ctg gtc agc gtc 1267Ser Ala Tyr Gly Leu Ala Val Thr Gly Thr Leu Val Leu Val Ser Val

375 380 385ctg tat ctg atc tat gtt cac acc aca tgg tgg aaa aca gcg ctg ttc 1315Leu Tyr Leu Ile Tyr Val His Thr Thr Trp Trp Lys Thr Ala Leu Phe390 395 400 405att gtg ctc atc ggt att cca gaa gta ctt cta ttc gcc tcg aac acc 1363Ile Val Leu Ile Gly Ile Pro Glu Val Leu Leu Phe Ala Ser Asn Thr

410 415 420acg aaa att cacgac ggt ggc tgg ctt cca cta ctt att gcg gcc gtg 1411Thr Lys Ile His Asp Gly Gly Trp Leu Pro Leu Leu Ile Ala Ala Val

425 430 435ctc atc gtg gtg atg cgg acc tgg gag tgg gga agt gac cgc gtc aat 1459Leu Ile Val Val Met Arg Thr Trp Glu Trp Gly Ser Asp Arg Val Asn

440 445 450cag gaa cgc gca gag ctg gaa ctt ccc atg gat aag ttc ttg gag aaa 1507Gln Glu Arg Ala Glu Leu Glu Leu Pro Met Asp Lys Phe Leu Glu Lys

455 460 465ctc gat cag cca cac aat att ggt ctg cgt aaa gtt gcc gaa gtg gca 1555Leu Asp Gln Pro His Asn Ile Gly Leu Arg Lys Val Ala Glu Val Ala470 475 480 485gta ttt cca cat ggc acc agc gat act gtc ccg ttg tca ttg gtt cgc 1603Val Phe Pro His Gly Thr Ser Asp Thr Val Pro Leu Ser Leu Val Arg

490 495 500tgc gtg aaa gac ctc aag ctt tta tac cga gag atc gtg atc gtt cga 1651Cys Val Lys Asp Leu Lys Leu Leu Tyr Arg Glu Ile Val Ile Val Arg

505 510 515atc gtc caa gaa cac gtt ccg cac gtg cca cca gag gaa cgc gcg gaa 1699Ile Val Gln Glu His Val Pro His Val Pro Pro Glu Glu Arg Ala Glu

520 525 530atg gaa gtg ctc cat cac gcc ccg atc aga gtc gtg cga gtt gat ctg 1747Met Glu Val Leu His His Ala Pro Ile Arg Val Val Arg Val Asp Leu

535 540 545cac ctt ggt tat ttt gat gag cag aac ctg cct gag cat ctc cat gcc 1795His Leu Gly Tyr Phe Asp Glu Gln Asn Leu Pro Glu His Leu His Ala550 555 560 565att gac cca aca tgg gat aac gcc acc tac ttc ctg tct gcc ctg act 1843Ile Asp Pro Thr Trp Asp Asn Ala Thr Tyr Phe Leu Ser Ala Leu Thr

570 575 580ctt cgg agc agg ttg cct gga aag att gct ggc tgg cgt gat cgt ttg 1891Leu Arg Ser Arg Leu Pro Gly Lys Ile Ala Gly Trp Arg Asp Arg Leu

585 590 595tat ctt tcg atg gaa cgt aat cag gca tct cga act gag tct ttc aaa 1939Tyr Leu Ser Met Glu Arg Asn Gln Ala Ser Arg Thr Glu Ser Phe Lys

600 605 610ttg caa cca agc aaa acc atc acg gtt gga aca gag ctg cac ctt 1984Leu Gln Pro Ser Lys Thr Ile Thr Val Gly Thr Glu Leu His Leu

615620625 taatcaggca gttgctggcc aac 2007<210>666<211>628<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>666Met Leu Asn Arg Met Lys Ser Ala Arg Pro Lys Ser Val Ala Pro Lys 151015 Ser Gly Gln Ala Leu Leu Thr Leu Gly Ala Leu Gly Val Val Phe Gly

20 25 30Asp Ile Gly Thr Ser Pro Leu Tyr Ser Leu His Thr Ala Phe Ser Met

35 40 45Gln His Asn Lys Val Glu Val Thr Gln Glu Asn Val Tyr Gly Ile Ile

50 55 60Ser Met Val Leu Trp Thr Ile Thr Leu Ile Val Thr Val Lys Tyr Val 65 70 75 80Met Leu Val Thr Arg Ala Asp Asn Gln Gly Gln Gly Gly Ile Leu Ala

85 90 95Leu Val Ala Leu Leu Lys Asn Arg Gly His Trp Gly Lys Phe Val Ala

100 105 110Val Ala Gly Met Leu Gly Ala Ala Leu Phe Tyr Gly Asp Val Val Ile

115 120 125Thr Pro Ala Ile Ser Val Leu Ser Ala Thr Glu Gly Leu Thr Val Ile

130 135 140Ser Pro Ser Phe Glu Arg Phe Ile Leu Pro Val Ser Leu Ala Val Leu145 150 155 160Ile Ala Ile Phe Ala Ile Gln Pro Leu Gly Thr Glu Lys Val Gly Lys

165 170 175Ala Phe Gly Pro Ile Met Leu Leu Trp Phe Val Thr Leu Ala Gly Leu

180 185 190Gly Ile Pro Gln Ile Ile Gly His Pro Glu Ile Leu Gln Ser Leu Ser

195 200 205Pro His Trp Ala Leu Arg Leu Ile Val Ala Glu Pro Phe Gln Ala Phe

210 215 220Val Leu Leu Gly Ala Val Val Leu Thr Val Thr Gly Ala Glu Ala Leu225 230 235 240Tyr Ala Asp Met Gly His Phe Gly Ala Arg Pro Ile Arg Val Ala Trp

245 250 255Phe Cys Val Val Met Pro Ala Leu Ile Leu Thr Tyr Leu Gly Gln Gly

260 265 270Ala Leu Val Ile Asn Gln Pro Glu Ala Val Arg Asn Pro Met Phe Tyr

275 280 285Leu Ala Pro Glu Gly Leu Arg Ile Pro Leu Val Ile Leu Ala Thr Ile

290 295 300Ala Thr Val Ile Ala Ser Gln Ala Val Ile Ser Gly Ala Tyr Ser Leu305 310 315 320Thr Lys Gln Ala Val Asn Leu Lys Leu Leu Pro Arg Met Val Ile Arg

325 330 335His Thr Ser Arg Lys Glu Glu Gly Gln Ile Tyr Met Pro Leu Val Asn

340 345 350Gly Leu Leu Phe Val Ser Val Met Val Val Val LeuVal Phe Arg Ser

355 360 365Ser Glu Ser Leu Ala Ser Ala Tyr Gly Leu Ala Val Thr Gly Thr Leu

370 375 380Val Leu Val Ser Val Leu Tyr Leu Ile Tyr Val His Thr Thr Trp Trp385 390 395 400Lys Thr Ala Leu Phe Ile Val Leu Ile Gly Ile Pro Glu Val Leu Leu

405 410 415Phe Ala Ser Asn Thr Thr Lys Ile His Asp Gly Gly Trp Leu Pro Leu

420 425 430Leu Ile Ala Ala Val Leu Ile Val Val Met Arg Thr Trp Glu Trp Gly

435 440 445Ser Asp Arg Val Asn Gln Glu Arg Ala Glu Leu Glu Leu Pro Met Asp

450 455 460Lys Phe Leu Glu Lys Leu Asp Gln Pro His Asn Ile Gly Leu Arg Lys465 470 475 480Val Ala Glu Val Ala Val Phe Pro His Gly Thr Ser Asp Thr Val Pro

485 490 495Leu Ser Leu Val Arg Cys Val Lys Asp Leu Lys Leu Leu Tyr Arg Glu

500 505 510Ile Val Ile Val Arg Ile Val Gln Glu His Val Pro His Val Pro Pro

515 520 525Glu Glu Arg Ala Glu Met Glu Val Leu His His Ala Pro Ile Arg Val

530 535 540Val Arg Val Asp Leu His Leu Gly Tyr Phe Asp Glu Gln Asn Leu Pro545 550 555 560Glu His Leu His Ala Ile Asp Pro Thr Trp Asp Asn Ala Thr Tyr Phe

565 570 575Leu Ser Ala Leu Thr Leu Arg Ser ArgLeu Pro Gly Lys Ile Ala Gly

580 585 590Trp Arg Asp Arg Leu Tyr Leu Ser Met Glu Arg Asn Gln Ala Ser Arg

595 600 605Thr Glu Ser Phe Lys Leu Gln Pro Ser Lys Thr Ile Thr Val Gly Thr

610615620 Glu Leu His Leu625<210>667<211>1656<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) }, (1633)<223>RXA02426<400>667tgcagcagca taatcaggga aaaataggaa ctgtttactg aaaaactgac aaacctgaca 60gacctgaccc gaagagacct tattcatgac gatattgttc atg ctc att aca ttg 115

Met Leu Ile Thr Leu

1 5ctg ctc gcc acc gtg att gtg gtg gcc atc ggc gat aaa acc gga ctc 163Leu Leu Ala Thr Val Ile Val Val Ala Ile Gly Asp Lys Thr Gly Leu

10 15 20ccc tgg cct gct ttg atg act att gtc gcc gca ggt gga gcg ttg ttg 211Pro Trp Pro Ala Leu Met Thr Ile Val Ala Ala Gly Gly Ala Leu Leu

25 30 35cca ttt ttg ccg gaa ttt act atc ccg gcc gat ctg atg ttg cct att 259Pro Phe Leu Pro Glu Phe Thr Ile Pro Ala Asp Leu Met Leu Pro Ile

40 45 50ttc att ccg ccg ctg ctg tgg gcg ctg gcg agg aag tca tcg tgg gcg 307Phe Ile Pro Pro Leu Leu Trp Ala Leu Ala Arg Lys Ser Ser Trp Ala

55 60 65gtg att agg tcg cag atg tct acc atc atc acg atg tcg gtg ttg ttg 355Val Ile Arg Ser Gln Met Ser Thr Ile Ile Thr Met Ser Val Leu Leu 70 75 80 85gtg ttc gtg acc atc gcg gca ctc acg ggt gca tcc atg ctg ttg ctt 403Val Phe Val Thr Ile Ala Ala Leu Thr Gly Ala Ser Met Leu Leu Leu

90 95 100cct ggc att ggt ctt gct ggt gcg atc atg ttg gct gcg gct att gct 451Pro Gly Ile Gly Leu Ala Gly Ala Ile Met Leu Ala Ala Ala Ile Ala

105 110 115cca ccg gat cct gtt gct gtt gat gca gtg gcg gaa cct gcg gga atc 499Pro Pro Asp Pro Val Ala Val Asp Ala Val Ala Glu Pro Ala Gly Ile

120 125 130ccg aag cgc atc acc acc act ttg cag acg gag ggt ctg ttt aat gat 547Pro Lys Arg Ile Thr Thr Thr Leu Gln Thr Glu Gly Leu Phe Asn Asp

135 140 145gca gcc agc atc gtg gcg ttc cat gtg gct tta gct gcc ctg gtc gct 595Ala Ala Ser Ile Val Ala Phe His Val Ala Leu Ala Ala Leu Val Ala150 155 160 165ggt gag gat ttg tcc tgg tca acg ggt gtt ttg gaa ttc ttg tgg tcg 643Gly Glu Asp Leu Ser Trp Ser Thr Gly Val Leu Glu Phe Leu Trp Ser

170 175 180tgt ctt gct gcc gtt att ttg ggc ttg gtt att ggc cgg gcg gct gcg 691Cys Leu Ala Ala Val Ile Leu Gly Leu Val Ile Gly Arg Ala Ala Ala

185 190 195 tgg ttt acc gat cac gtg agt tcc gtt gag gct cga aat gcg ttt acg 739Trp Phe Thr Asp His Val Ser Ser Val Glu Ala Arg Asn Ala Phe Thr

200 205 210tgg gtg ctg ccg ttt gcc att tat gtg gtg gcg gaa gaa atc ggc gga 787Trp Val Leu Pro Phe Ala Ile Tyr Val Val Ala Glu Glu Ile Gly Gly

215 220 225tcg ggc gtt atc gcc att gtg atc gct gca gtg gag atg aat tcg agg 835Ser Gly Val IleAla Ile Val Ile Ala Ala Val Glu Met Asn Ser Arg230 235 240 245gcg tcg att ggt gcg gag gat cgt cta acg ggt tct gcg ttc tgg gga 883Ala Ser Ile Gly Ala Glu Asp Arg Leu Thr Gly Ser Ala Phe Trp Gly

250 255 260acc att gag gtg ctg ttt act ggc gtt gcc ttt ggt ttg atc ggc ctg 931Thr Ile Glu Val Leu Phe Thr Gly Val Ala Phe Gly Leu Ile Gly Leu

265 270 275aat gtg cgc gct gcg att gat gaa gtt gga tct gag ctg tgg cat gcc 979Asn Val Arg Ala Ala Ile Asp Glu Val Gly Ser Glu Leu Trp His Ala

280 285 290gtg gtc gtg ggc att gtg ctc tcg gtg gtg gcg atc gtt gtc cgt ggt 1027Val Val Val Gly Ile Val Leu Ser Val Val Ala Ile Val Val Arg Gly

295 300 305gtg tgg atg ttc gcg gcg tat aag cgc aat cgt ttc aag atc gat aag 1075Val Trp Met Phe Ala Ala Tyr Lys Arg Asn Arg Phe Lys Ile Asp Lys310 315 320 325aag ggt gcg acc aat agt tca ttg cgg gcg cct ctt cga ctg cag gaa 1123Lys Gly Ala Thr Asn Ser Ser Leu Arg Ala Pro Leu Arg Leu Gln Glu

330 335 340tcg ttg ctg atg acg tgg gcg ggc atg cgc ggt ttg gtg acg ttg gcg 1171Ser Leu Leu Met Thr Trp Ala Gly Met Arg Gly Leu Val Thr Leu Ala

345 350 355ctg gtg ctg tct att ccg gag gat att ttc ccg tat cac cac gag ttg 1219Leu Val Leu Ser Ile Pro Glu Asp Ile Phe Pro Tyr His His Glu Leu

360 365 370cag gtc att gcg ctg gtc gtt ctc tta atc acc atg gtg ggc cct ggt 1267Gln Val Ile Ala Leu Val Val Leu Leu Ile Thr Met Val Gly Pro Gly

375 380385ttg acg ttg ccg tgg ctg atg cgg aag ctc agc ttg gat aag ggt ccc 1315Leu Thr Leu Pro Trp Leu Met Arg Lys Leu Ser Leu Asp Lys Gly Pro390 395 400 405gat gct gcg ggc gat gag agt atc gcc gcg ctg aca gag agg gct cac 1363Asp Ala Ala Gly Asp Glu Ser Ile Ala Ala Leu Thr Glu Arg Ala His

410 415 420aag gcc gca aca acg tat ttg gtg gat acc acg gag ttg ccg atg gag 1411Lys Ala Ala Thr Thr Tyr Leu Val Asp Thr Thr Glu Leu Pro Met Glu

425 430 435cag atg gtg gcg atc aag aat tgg ttc tcg caa gaa att gac gct gat 1459Gln Met Val Ala Ile Lys Asn Trp Phe Ser Gln Glu Ile Asp Ala Asp

440 445 450gaa ctg cag gag aac gtc gat aag ctg cat cag cgc gcg cat cat gcg 1507Glu Leu Gln Glu Asn Val Asp Lys Leu His Gln Arg Ala His His Ala

455 460 465cgt gtc ggg gca att aag gcg gcc cag gag gag ctg ttg aag gcg cgg 1555Arg Val Gly Ala Ile Lys Ala Ala Gln Glu Glu Leu Leu Lys Ala Arg470 475 480 485cgg gag cgc ggc gtt aat ccg gcc tat gtt gat gag gtg ttg acc aac 1603Arg Glu Arg Gly Val Asn Pro Ala Tyr Val Asp Glu Val Leu Thr Asn

490 495 500att gac cgg atg ctt gtt gcg gct gaa cgc tagataaaca gcagcaggct 1653Ile Asp Arg Met Leu Val Ala Ala Glu Arg

505510 gat1656<210>668<211>511<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>668Met Leu Ile Thr Leu Leu Leu Ala Thr Val Ile Val Val Ala Ile Gly 151015 Asp Lys Thr Gly Leu Pro Trp Pro Ala Leu Met Thr Ile Val Ala Ala

20 2530Gly Gly Ala Leu Leu Pro Phe Leu Pro Glu Phe Thr Ile Pro Ala Asp

35 40 45Leu Met Leu Pro Ile Phe Ile Pro Pro Leu Leu Trp Ala Leu Ala Arg

50 55 60Lys Ser Ser Trp Ala Val Ile Arg Ser Gln Met Ser Thr Ile Ile Thr 65 70 75 80Met Ser Val Leu Leu Val Phe Val Thr Ile Ala Ala Leu Thr Gly Ala

85 90 95Ser Met Leu Leu Leu Pro Gly Ile Gly Leu Ala Gly Ala Ile Met Leu

100 105 110Ala Ala Ala Ile Ala Pro Pro Asp Pro Val Ala Val Asp Ala Val Ala

115 120 125Glu Pro Ala Gly Ile Pro Lys Arg Ile Thr Thr Thr Leu Gln Thr Glu

130 135 140Gly Leu Phe Asn Asp Ala Ala Ser Ile Val Ala Phe His Val Ala Leu145 150 155 160Ala Ala Leu Val Ala Gly Glu Asp Leu Ser Trp Ser Thr Gly Val Leu

165 170 175Glu Phe Leu Trp Ser Cys Leu Ala Ala Val Ile Leu Gly Leu Val Ile

180 185 190Gly Arg Ala Ala Ala Trp Phe Thr Asp His Val Ser Ser Val Glu Ala

195 200 205Arg Asn Ala Phe Thr Trp Val Leu Pro Phe Ala Ile Tyr Val Val Ala

210 215 220Glu Glu Ile Gly Gly Ser Gly Val Ile Ala Ile Val Ile Ala Ala Val225 230 235 240Glu Met Asn Ser Arg Ala Ser Ile Gly Ala Glu Asp Arg Leu Thr Gly

245 250255Ser Ala Phe Trp Gly Thr Ile Glu Val Leu Phe Thr Gly Val Ala Phe

260 265 270Gly Leu Ile Gly Leu Asn Val Arg Ala Ala Ile Asp Glu Val Gly Ser

275 280 285Glu Leu Trp His Ala Val Val Val Gly Ile Val Leu Ser Val Val Ala

290 295 300Ile Val Val Arg Gly Val Trp Met Phe Ala Ala Tyr Lys Arg Asn Arg305 310 315 320Phe Lys Ile Asp Lys Lys Gly Ala Thr Asn Ser Ser Leu Arg Ala Pro

325 330 335Leu Arg Leu Gln Glu Ser Leu Leu Met Thr Trp Ala Gly Met Arg Gly

340 345 350Leu Val Thr Leu Ala Leu Val Leu Ser Ile Pro Glu Asp Ile Phe Pro

355 360 365Tyr His His Glu Leu Gln Val Ile Ala Leu Val Val Leu Leu Ile Thr

370 375 380Met Val Gly Pro Gly Leu Thr Leu Pro Trp Leu Met Arg Lys Leu Ser385 390 395 400Leu Asp Lys Gly Pro Asp Ala Ala Gly Asp Glu Ser Ile Ala Ala Leu

405 410 415Thr Glu Arg Ala His Lys Ala Ala Thr Thr Tyr Leu Val Asp Thr Thr

420 425 430Glu Leu Pro Met Glu Gln Met Val Ala Ile Lys Asn Trp Phe Ser Gln

435 440 445Glu Ile Asp Ala Asp Glu Leu Gln Glu Asn Val Asp Lys Leu His Gln

450 455 460Arg Ala His His Ala Arg Val Gly Ala Ile Lys Ala Ala Gln Glu Glu465 470 475 480Leu Leu LysAla Arg Arg Glu Arg Gly Val Asn Pro Ala Tyr Val Asp

485 490 495Glu Val Leu Thr Asn Ile Asp Arg Met Leu Val Ala Ala Glu Arg

500505510<210>669<211>993<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (970)<223>RXN03164<400>669cttttttgca tccagatgca caaagccgtg gcacaaacga gacaaactga gcacaatggc 60tgtcatggca tatcaaccag cagacaatcg ctatgacgac atg atc tac cgc agg 115

Met Ile Tyr Arg Arg

1 5gtg gga aat tct ggg ctg aag ctt ccg gca att tcg ctt ggg ctg tgg 163Val Gly Asn Ser Gly Leu Lys Leu Pro Ala Ile Ser Leu Gly Leu Trp

10 15 20cac aac ttc ggt gat gac aag ccg ctt tca acg cag cgc agc att att 211His Asn Phe Gly Asp Asp Lys Pro Leu Ser Thr Gln Arg Ser Ile Ile

25 30 35cac cgc gcg ttt gat agg gga gtc act cac ttc gat ttg gct aat aac 259His Arg Ala Phe Asp Arg Gly Val Thr His Phe Asp Leu Ala Asn Asn

40 45 50tat gga cct cca gca ggt tcc gca gag acc aac ttt ggc agg att ttg 307Tyr Gly Pro Pro Ala Gly Ser Ala Glu Thr Asn Phe Gly Arg Ile Leu

55 60 65cgt gag gat ctc aaa agc cac cgc gat gag ttg atc att tct tcc aag 355Arg Glu Asp Leu Lys Ser His Arg Asp Glu Leu Ile Ile Ser Ser Lys 70 75 80 85gcg ggt tgg gat atg tgg cct gga cct tat ggt ttt ggt ggt tcc cga 403Ala Gly Trp Asp Met Trp Pro Gly Pro Tyr Gly Phe Gly Gly Ser Arg

90 95 100aag tat cta gtg agt tcc ctt gat cag tcc ctg act cgc ctc ggc ttg 451Lys Tyr Leu Val Ser Ser Leu Asp Gln Ser Leu Thr Arg Leu Gly Leu

105 110 115gat tac gtg gat att ttc tat cat cac cgc ccg gat cca gat act cct 499Asp Tyr Val Asp Ile Phe Tyr His His Arg Pro Asp Pro Asp Thr Pro

120 125 130ttg gaa gaa acc atg tac gca ttg cgt gac att gtt gcg tct gga aag 547Leu Glu Glu Thr Met Tyr Ala Leu Arg Asp Ile Val Ala Ser Gly Lys

135 140 145gct ctt tac gtg ggt att tct tcc tac ggt cca gag ctc aca gcg gag 595Ala Leu Tyr Val Gly Ile Ser Ser Tyr Gly Pro Glu Leu Thr Ala Glu150 155 160 165gcg gct gag ttc atg gcg gag gag ggc tgc ccg ctt ctg att cat cag 643Ala Ala Glu Phe Met Ala Glu Glu Gly Cys Pro Leu Leu Ile His Gln

170 175 180cca agc tat tcc atc att aat cgt tgg gtg gag gaa ccg ggc gat gac 691Pro Ser Tyr Ser Ile Ile Asn Arg Trp Val Glu Glu Pro Gly Asp Asp

185 190 195ggt gag aac ttg ttg cag tca gct gcc aac aat ggt ctt ggc gtc att 739Gly Glu Asn Leu Leu Gln Ser Ala Ala Asn Asn Gly Leu Gly Val Ile

200 205 210gct ttc tca cca ctt gcg cag ggc ctg ctc acg gac aaa tat ctc gat 787Ala Phe Ser Pro Leu Ala Gln Gly Leu Leu Thr Asp Lys Tyr Leu Asp

215 220 225gga att cca gag ggt tcc cgc gcc agc cag ggt aag tcc ctg tct gag 835Gly Ile Pro Glu Gly Ser Arg Ala Ser Gln Gly Lys Ser Leu Ser Glu230 235 240 245ggc atg ttg aac gtg aac aat att gat atg gtc cgc aagctc aat gac 883Gly Met Leu Asn Val Asn Asn Ile Asp Met Val Arg Lys Leu Asn Asp

250 255 260atc gcc cag gaa cgc ggg cag tca ctt gcg cag atg gcg ctt gca tgg 931Ile Ala Gln Glu Arg Gly Gln Ser Leu Ala Gln Met Ala Leu Ala Trp

265 270 275gtg ctg cgc gag caa aga gag tac ggc gcc gga tta ccg tgaccagtgc 980Val Leu Arg Glu Gln Arg Glu Tyr Gly Ala Gly Leu Pro

280285290 attgattggt gct 993<210>670<211>290<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>670Met Ile Tyr Arg Arg Val Gly Asn Ser Gly Leu Lys Leu Pro Ala Ile 151015 Ser Leu Gly Leu Trp His Asn Phe Gly Asp Asp Lys Pro Leu Ser Thr

20 25 30Gln Arg Ser Ile Ile His Arg Ala Phe Asp Arg Gly Val Thr His Phe

35 40 45Asp Leu Ala Asn Asn Tyr Gly Pro Pro Ala Gly Ser Ala Glu Thr Asn

50 55 60Phe Gly Arg Ile Leu Arg Glu Asp Leu Lys Ser His Arg Asp Glu Leu 65 70 75 80Ile Ile Ser Ser Lys Ala Gly Trp Asp Met Trp Pro Gly Pro Tyr Gly

85 90 95Phe Gly Gly Ser Arg Lys Tyr Leu Val Ser Ser Leu Asp Gln Ser Leu

100 105 110Thr Arg Leu Gly Leu Asp Tyr Val Asp Ile Phe Tyr His His Arg Pro

115 120 125Asp Pro Asp Thr Pro Leu Glu Glu Thr Met Tyr Ala Leu Arg Asp Ile

130 135 140Val Ala Ser Gly Lys Ala Leu Tyr Val Gly Ile Ser Ser Tyr Gly Pro145150 155 160Glu Leu Thr Ala Glu Ala Ala Glu Phe Met Ala Glu Glu Gly Cys Pro

165 170 175Leu Leu Ile His Gln Pro Ser Tyr Ser Ile Ile Asn Arg Trp Val Glu

180 185 190Glu Pro Gly Asp Asp Gly Glu Asn Leu Leu Gln Ser Ala Ala Asn Asn

195 200 205Gly Leu Gly Val Ile Ala Phe Ser Pro Leu Ala Gln Gly Leu Leu Thr

210 215 220Asp Lys Tyr Leu Asp Gly Ile Pro Glu Gly Ser Arg Ala Ser Gln Gly225 230 235 240Lys Ser Leu Ser Glu Gly Met Leu Asn Val Asn Asn Ile Asp Met Val

245 250 255Arg Lys Leu Asn Asp Ile Ala Gln Glu Arg Gly Gln Ser Leu Ala Gln

260 265 270Met Ala Leu Ala Trp Val Leu Arg Glu Gln Arg Glu Tyr Gly Ala Gly

275 280 285Leu Pro

290<210>671<211>1068<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101). (1045)<223>RXN00024<400>671ttaagacatc aacatatggc ttgtgctact gaaagatttt tcttctgaaa ttctgtagaa 60acgctcctat gctcggggca gtaagttgtg agcataggaa atg gag cac ggc gtg 115

Met Glu His Gly Val

1 5acc gtt att aaa ggc act gaa ttt gat gtt ttc cca cta aac ctc ggt 163Thr Val Ile Lys Gly Thr Glu Phe Asp Val Phe Pro Leu Asn Leu Gly

10 1520gga aat acc ttt ggc tgg acc tcg aat agg gaa cag acc ttc gcg gtt 211Gly Asn Thr Phe Gly Trp Thr Ser Asn Arg Glu Gln Thr Phe Ala Val

25 30 35ttg gat gca ttc gtg gca gcg gga gga aac ttt gtt gac acc gcc gat 259Leu Asp Ala Phe Val Ala Ala Gly Gly Asn Phe Val Asp Thr Ala Asp

40 45 50tct tat tct gca tgg gtt gaa ggc aat gag ggt ggc gag tcg gag cgg 307Ser Tyr Ser Ala Trp Val Glu Gly Asn Glu Gly Gly Glu Ser Glu Arg

55 60 65gag ctc ggc gcg tgg att aag gaa cgt ggc gca gac aag ctg atc att 355Glu Leu Gly Ala Trp Ile Lys Glu Arg Gly Ala Asp Lys Leu Ile Ile 70 75 80 85gct acc aag tct ggt gcg ttg gag cct gtt gct ggt cgt tcc cgt gag 403Ala Thr Lys Ser Gly Ala Leu Glu Pro Val Ala Gly Arg Ser Arg Glu

90 95 100gca act ttc aag gct gtc gag ggt tcc ctg gag cgt ttg ggc gtg gaa 451Ala Thr Phe Lys Ala Val Glu Gly Ser Leu Glu Arg Leu Gly Val Glu

105 110 115tcg atc gat att ttt tac tac cac tac gac gat gag gca gtc agc att 499Ser Ile Asp Ile Phe Tyr Tyr His Tyr Asp Asp Glu Ala Val Ser Ile

120 125 130gat gag cag gtt gct atc gct aat gat ctg att gca cag ggc aag att 547Asp Glu Gln Val Ala Ile Ala Asn Asp Leu Ile Ala Gln Gly Lys Ile

135 140 145aag cac ctc gca ttg tct aac tac agc gcg gag cgt tta gct gag ttc 595Lys His Leu Ala Leu Ser Asn Tyr Ser Ala Glu Arg Leu Ala Glu Phe150 155 160 165ttt gag aag tct gta ggc act cca gcg cag ccg gtt gct ctg caa ccg 643Phe Glu Lys Ser Val Gly Thr Pro Ala Gln Pro ValAla Leu Gln Pro

170 175 180cac tac aac ctg gtg tcg agg aag gat tat gag gag aac gtg cag cca 691His Tyr Asn Leu Val Ser Arg Lys Asp Tyr Glu Glu Asn Val Gln Pro

185 190 195ctc gcc gag aag cat ggc gtt gca gtc ttc cct tat ttc gcg ctt gcc 739Leu Ala Glu Lys His Gly Val Ala Val Phe Pro Tyr Phe Ala Leu Ala

200 205 210gcg ggt ctt ttg acc gga aag tac acc tcc aag gag gat att tcg ggt 787Ala Gly Leu Leu Thr Gly Lys Tyr Thr Ser Lys Glu Asp Ile Ser Gly

215 220 225aaa gcg cgt gcg ggg cag ttg gat cgt tac gcc agc gat gag gcg ttt 835Lys Ala Arg Ala Gly Gln Leu Asp Arg Tyr Ala Ser Asp Glu Ala Phe230 235 240 245gcc gtg gtg aca gag ttg cgt gct gtt gcc gat gag ttg ggt gtt gcg 883Ala Val Val Thr Glu Leu Arg Ala Val Ala Asp Glu Leu Gly Val Ala

250 255 260cca acg act gtg gcg ctt gcg tgg ttg gtt gcg cat ggt gtg acc gca 931Pro Thr Thr Val Ala Leu Ala Trp Leu Val Ala His Gly Val Thr Ala

265 270 275ccg att gcg tcc gtg tcc aag gta gag cag ttg aag gat ttg atg gct 979Pro Ile Ala Ser Val Ser Lys Val Glu Gln Leu Lys Asp Leu Met Ala

280 285 290gtg aag gat gtg gag ctg agc gct gag cag ctt gca cgt ttg gat aag 1027Val Lys Asp Val Glu Leu Ser Ala Glu Gln Leu Ala Arg Leu Asp Lys

295300305 gtt tcg gag cct ttc gct taagctctcc tcaaaagtaa gtg 1068Val Ser Glu Pro Phe Ala 310315 310210<210>672<211>315<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>672Met Glu His Gly Val Thr Val Ile Lys Gly Thr Glu Phe Asp Val Phe 151015 Pro Leu Asn Leu Gly Gly Asn Thr Phe Gly Trp Thr Ser Asn Arg Glu

20 25 30Gln Thr Phe Ala Val Leu Asp Ala Phe Val Ala Ala Gly Gly Asn Phe

35 40 45Val Asp Thr Ala Asp Ser Tyr Ser Ala Trp Val Glu Gly Asn Glu Gly

50 55 60Gly Glu Ser Glu Arg Glu Leu Gly Ala Trp Ile Lys Glu Arg Gly Ala65 70 75 80Asp Lys Leu Ile Ile Ala Thr Lys Ser Gly Ala Leu Glu Pro Val Ala

85 90 95Gly Arg Ser Arg Glu Ala Thr Phe Lys Ala Val Glu Gly Ser Leu Glu

100 105 110Arg Leu Gly Val Glu Ser Ile Asp Ile Phe Tyr Tyr His Tyr Asp Asp

115 120 125Glu Ala Val Ser Ile Asp Glu Gln Val Ala Ile Ala Asn Asp Leu Ile

130 135 140Ala Gln Gly Lys Ile Lys His Leu Ala Leu Ser Asn Tyr Ser Ala Glu145 150 155 160Arg Leu Ala Glu Phe Phe Glu Lys Ser Val Gly Thr Pro Ala Gln Pro

165 170 175Val Ala Leu Gln Pro His Tyr Asn Leu Val Ser Arg Lys Asp Tyr Glu

180 185 190Glu Asn Val Gln Pro Leu Ala Glu Lys His Gly Val Ala Val Phe Pro

195 200 205Tyr Phe Ala Leu Ala Ala Gly Leu Leu Thr Gly Lys Tyr Thr Ser Lys

210 215 220Glu Asp Ile Ser Gly Lys Ala Arg Ala Gly Gln Leu Asp Arg Tyr Ala225 230 235 240Ser Asp Glu Ala Phe Ala Val Val Thr Glu Leu Arg Ala Val Ala Asp

245 250 255Glu Leu Gly Val Ala Pro Thr Thr Val Ala Leu Ala Trp Leu Val Ala

260 265 270His Gly Val Thr Ala Pro Ile Ala Ser Val Ser Lys Val Glu Gln Leu

275 280 285Lys Asp Leu Met Ala Val Lys Asp Val Glu Leu Ser Ala Glu Gln Leu

290295300 Ala Arg Leu Asp Lys Val Ser Glu Pro Phe Ala 305310315<210>673<211>1758<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) · (1735)<223>RXN01164<400>673gccgatcgtg attgatgaag acgagatcca agcctggact tctgatctca aacctgaaga 60tttcaccaaa ggtaaagatg aatccgacgg tgagaaataa gtg aca ctg ttt gtt 115

Val Thr Leu Phe Val

1 5cgg ctc gcc ctt gct gct gtg ggc ggg ctt ttt gtc ttt gct tcc aat 163Arg Leu Ala Leu Ala Ala Val Gly Gly Leu Phe Val Phe Ala Ser Asn

10 15 20gaa ccg atc ggc tgg ttt gtc gcg gga att gtt ggc act gca tta ttt 211Glu Pro Ile Gly Trp Phe Val Ala Gly Ile Val Gly Thr Ala Leu Phe

25 30 35ttt atc tcc ctt gcg ccg tgg gat ctg gga gtt ccc caa aag cgg cgg 259Phe Ile Ser Leu Ala Pro Trp Asp Leu Gly Val Pro Gln Lys Arg Arg

40 45 50aag aag aat gag cca gtc cca ttt ttg caa cag atg tcc acg ggc cca 307Lys Lys Asn Glu Pro Val Pro Phe Leu Gln Gln Met Ser Thr Gly Pro

55 60 65act gtt gta cag ggc atg ctt tta ggt ttt gtc cat ggc ctg gtg aca 355Thr Val Val Gln Gly Met Leu Leu Gly Phe Val His Gly Leu Val Thr 70 75 80 85tat ttg cag ctg ttg ccg tgg atc ggt gag ttt gtt ggc tca ctg cct 403Tyr Leu Gln Leu Leu Pro Trp Ile Gly Glu Phe Val Gly Ser Leu Pro

90 95 100tat gtc gcg ttg tca gtt gtc gag gcg ctt tat tcc att gct ctt ggt 451Tyr Val Ala Leu Ser Val Val Glu Ala Leu Tyr Ser Ile Ala Leu Gly

105 110 115gct ttc ggc gtg ctc att gcg cgt tgg agg gac tgg aag gtt ctc ctg 499Ala Phe Gly Val Leu Ile Ala Arg Trp Arg Asp Trp Lys Val Leu Leu

120 125 130ttt ccg gcg atg tat gtg gct gtg gag tat cta aga agc tcg tgg cca 547Phe Pro Ala Met Tyr Val Ala Val Glu Tyr Leu Arg Ser Ser Trp Pro

135 140 145ttt gat gga ttc gcg tgg gtt cgc ctg gca tgg ggt caa att aac ggt 595Phe Asp Gly Phe Ala Trp Val Arg Leu Ala Trp Gly Gln Ile Asn Gly150 155 160 165ccg ttg gct aat ctc gca gcg ctt ggt ggg gta gcg ttt gtc act ttt 643Pro Leu Ala Asn Leu Ala Ala Leu Gly Gly Val Ala Phe Val Thr Phe

170 175 180tcc acg gtg ctg gct gcc gtg ggt gtg gcc atg gtg att att tcc aag 691Ser Thr Val Leu Ala Ala Val Gly Val Ala Met Val Ile Ile Ser Lys

185 190 195aag cga ctg gcc ggc gca atc atc acc gcg agt gtg att gct atc ggc 739Lys Arg Leu Ala Gly Ala Ile Ile Thr Ala Ser Val Ile Ala Ile Gly

200 205 210gcg gtg tca tcc ctg tac gtt gac cgc aat ggc acg agc gat gaa agc 787Ala Val Ser Ser Leu Tyr Val Asp Arg Asn Gly Thr Ser Asp Glu Ser

215 220 225atc gaa gta gcc gca att cag ggc aat gtg cct cgg atg gga ttg gac 835Ile Glu Val Ala Ala Ile Gln Gly Asn Val Pro Arg Met Gly Leu Asp230 235 240 245ttc aat gca cag cgc cgc gcg gtg ctg gcg aat cac gca cgg gaa acc 883Phe Asn Ala Gln Arg Arg Ala Val Leu Ala Asn His Ala Arg Glu Thr

250 255 260ctc aag ctg gat gaa caa gtg gat ttg gtg atc tgg ccg gag aat tcc 931Leu Lys Leu Asp Glu Gln Val Asp Leu Val Ile Trp Pro Glu Asn Ser

265 270 275tca gac gtc aac cca ttt tcc gat gca caa gca aga gcc att atc gat 979Ser Asp Val Asn Pro Phe Ser Asp Ala Gln Ala Arg Ala Ile Ile Asp

280 285 290gga gca gtg gaa cat gtt cag gca cct att ttg gtg ggc acg atc acc 1027Gly Ala Val Glu His Val Gln Ala Pro Ile Leu Val Gly Thr Ile Thr

295 300 305gtc gat gag gtt ggt cca cgc aac acc atg cag gta ttt gat cct gtt 1075Val Asp Glu Val Gly Pro Arg Asn Thr Met Gln Val Phe Asp Pro Val310 315 320 325gaa ggt gcc gcg gag tac cac aat aag aag ttc ttg cag ccg ttt ggt 1123Glu Gly Ala Ala Glu Tyr His Asn Lys Lys Phe Leu Gln Pro Phe Gly

330 335 340gaa tac atg ccg ttt cgc gaa ttc ctg aga att ttc tcg ccc tac gtt 1171Glu Tyr Met Pro Phe Arg Glu Phe Leu Arg Ile Phe Ser Pro Tyr Val

345 350 355gat tcc gct gga aac ttc cag ccc ggt gat ggc acc ggc gta gtg gag 1219Asp Ser Ala Gly Asn Phe Gln Pro Gly Asp Gly Thr Gly Val Val Glu

360 365 370atg aat gct gcg aac tta ggc cgc gct gtg aca gtg ggc gtg atg acg 1267Met Asn Ala Ala Asn Leu Gly Arg Ala Val Thr Val Gly Val Met Thr

375 380 385tgt tac gag gtc atc ttc gac cgt gct ggc cgc gac gcc atc gcc aat 1315Cys Tyr Glu Val Ile Phe Asp Arg Ala Gly Arg Asp Ala Ile Ala Asn390 395 400 405ggg gct gaa ttt ttg acc acg ccc acc aac aac gcc acc ttc gga ttc 1363Gly Ala Glu Phe Leu Thr Thr Pro Thr Asn Asn Ala Thr Phe Gly Phe

410 415 420acg gac atg acg tat cag caa tta gca atg agc agg atg cgt gcc atc 1411Thr Asp Met Thr Tyr Gln Gln Leu Ala Met Ser Arg Met Arg Ala Ile

425 430 435gaa ttt gat agg gcg gtg gtt gtt gca gct aca tcg ggt gtt tcg gct 1459Glu Phe Asp Arg Ala Val Val Val Ala Ala Thr Ser Gly Val Ser Ala

440 445 450atc gtc aac cct gat gga agc att tcc caa aac acc cga att ttt gag 1507Ile Val Asn Pro Asp Gly Ser Ile Ser Gln Asn Thr Arg Ile Phe Glu

455 460 465gcc gcc acc ttg acg gaa tcc att cca ctc aag gac act gtc acc atc 1555Ala Ala Thr Leu Thr Glu Ser Ile Pro Leu Lys Asp Thr Val Thr Ile470 475 480 485gca gcg cgg gtt ggt ttc tat gtt gaa tta ctg ttg gtt atc att ggt 1603Ala Ala Arg Val Gly Phe Tyr Val Glu Leu Leu Leu Val Ile Ile Gly

490 495 500gta tta gct gga cta ttc gcc att cga atg aat agc cgt tca aag tct 1651Val Leu Ala Gly Leu Phe Ala Ile Arg Met Asn Ser Arg Ser Lys Ser

505 510 515gcg aaa ggt tcc gct cgg ccc gca caa gtt cgg gtt aag aag gtg cct 1699Ala Lys Gly Ser Ala Arg Pro Ala Gln Val Arg Val Lys Lys Val Pro

520 525 530gcg aaa aag gca gca act aat cgt cga aaa gta aaa taaaaacgtc 1745Ala Lys Lys Ala Ala Thr Asn Arg Arg Lys Val Lys

535540545 ccgaagggac gag 1758<210>674<211>545<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>674Val Thr Leu Phe Val Arg Leu Ala Leu Ala Ala Val Gly Gly Leu Phe 151015 Val Phe Ala Ser Asn Glu Pro Ile Gly Trp Phe Val Ala Gly Ile Val

20 25 30Gly Thr Ala Leu Phe Phe Ile Ser Leu Ala Pro Trp Asp Leu Gly Val

35 40 45Pro Gln Lys Arg Arg Lys Lys Asn Glu Pro Val Pro Phe Leu Gln Gln

50 55 60Met Ser Thr Gly Pro Thr Val Val Gln Gly Met Leu Leu Gly Phe Val 65 70 75 80His Gly Leu Val Thr Tyr Leu Gln Leu Leu Pro Trp Ile Gly Glu Phe

85 90 95Val Gly Ser Leu Pro Tyr Val Ala Leu Ser Val Val Glu Ala Leu Tyr

100 105 110Ser Ile Ala Leu Gly Ala Phe Gly Val Leu Ile Ala Arg Trp Arg Asp

115 120 125Trp Lys Val Leu Leu Phe Pro Ala Met Tyr Val Ala Val Glu Tyr Leu

130 135 140Arg Ser Ser Trp Pro Phe Asp Gly Phe Ala Trp Val Arg Leu Ala Trp145 150 155 160Gly Gln Ile Asn Gly Pro Leu Ala Asn Leu Ala Ala Leu Gly Gly Val

165170 175Ala Phe Val Thr Phe Ser Thr Val Leu Ala Ala Val Gly Val Ala Met

180 185 190Val Ile Ile Ser Lys Lys Arg Leu Ala Gly Ala Ile Ile Thr Ala Ser

195 200 205Val Ile Ala Ile Gly Ala Val Ser Ser Leu Tyr Val Asp Arg Asn Gly

210 215 220Thr Ser Asp Glu Ser Ile Glu Val Ala Ala Ile Gln Gly Asn Val Pro225 230 235 240Arg Met Gly Leu Asp Phe Asn Ala Gln Arg Arg Ala Val Leu Ala Asn

245 250 255His Ala Arg Glu Thr Leu Lys Leu Asp Glu Gln Val Asp Leu Val Ile

260 265 270Trp Pro Glu Asn Ser Ser Asp Val Asn Pro Phe Ser Asp Ala Gln Ala

275 280 285Arg Ala Ile Ile Asp Gly Ala Val Glu His Val Gln Ala Pro Ile Leu

290 295 300Val Gly Thr Ile Thr Val Asp Glu Val Gly Pro Arg Asn Thr Met Gln305 310 315 320Val Phe Asp Pro Val Glu Gly Ala Ala Glu Tyr His Asn Lys Lys Phe

325 330 335Leu Gln Pro Phe Gly Glu Tyr Met Pro Phe Arg Glu Phe Leu Arg Ile

340 345 350Phe Ser Pro Tyr Val Asp Ser Ala Gly Asn Phe Gln Pro Gly Asp Gly

355 360 365Thr Gly Val Val Glu Met Asn Ala Ala Asn Leu Gly Arg Ala Val Thr

370 375 380Val Gly Val Met Thr Cys Tyr Glu Val Ile Phe Asp Arg Ala Gly Arg385 390 395 400Asp Ala Ile Ala Asn Gly Ala Glu Phe Leu Thr Thr Pro Thr Asn Asn

405 410 415Ala Thr Phe Gly Phe Thr Asp Met Thr Tyr Gln Gln Leu Ala Met Ser

420 425 430Arg Met Arg Ala Ile Glu Phe Asp Arg Ala Val Val Val Ala Ala Thr

435 440 445Ser Gly Val Ser Ala Ile Val Asn Pro Asp Gly Ser Ile Ser Gln Asn

450 455 460Thr Arg Ile Phe Glu Ala Ala Thr Leu Thr Glu Ser Ile Pro Leu Lys465 470 475 480Asp Thr Val Thr Ile Ala Ala Arg Val Gly Phe Tyr Val Glu Leu Leu

485 490 495Leu Val Ile Ile Gly Val Leu Ala Gly Leu Phe Ala Ile Arg Met Asn

500 505 510Ser Arg Ser Lys Ser Ala Lys Gly Ser Ala Arg Pro Ala Gln Val Arg

515 520 525Val Lys Lys Val Pro Ala Lys Lys Ala Ala Thr Asn Arg Arg Lys Val

530535540 Lys545<210>675<211>933<212>DNA<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<220><221>CDS<222>(101) } (910)<223>RXN01168<400>675ccgcacaagt tcgggttaag aaggtgcctg cgaaaaaggc agcaactaat cgtcgaaaag 60taaaataaaa acgtcccgaa gggacgagga ggacaacacc atg agc agt gag gca 115

Met Ser Ser Glu Ala

1 5gta gat gct acg acg ctg gtg att att cca acg tac aac gag ctg gaa 163Val Asp Ala Thr Thr Leu Val Ile Ile Pro Thr Tyr Asn Glu Leu Glu

1015 20aac ctt cca ctc atc gtg gat cgc gtg cgc acc gca acc cct gac gtt 211Asn Leu Pro Leu Ile Val Asp Arg Val Arg Thr Ala Thr Pro Asp Val

25 30 35cac gta ctc atc gtg gac gac aac agc cca gac ggc acc ggc gag cgc 259His Val Leu Ile Val Asp Asp Asn Ser Pro Asp Gly Thr Gly Glu Arg

40 45 50gca gac aag ctt gct gct gac gac gac cac att ttt gtc ctc cac cgc 307Ala Asp Lys Leu Ala Ala Asp Asp Asp His Ile Phe Val Leu His Arg

55 60 65gaa ggc aaa ggc ggc ctg tgc gca gag tac atg gct ggc ttc cag tgg 355Glu Gly Lys Gly Gly Leu Cys Ala Glu Tyr Met Ala Gly Phe Gln Trp 70 75 80 85ggc ctg gag cgc gac tac cag gtc ctg tgc gaa atg gac gcc gac ggc 403Gly Leu Glu Arg Asp Tyr Gln Val Leu Cys Glu Met Asp Ala Asp Gly

90 95 100tcc cac gca cca gaa cag ctg cac ctg ctg ctc gct gag atc acc aat 451Ser His Ala Pro Glu Gln Leu His Leu Leu Leu Ala Glu Ile Thr Asn

105 110 115ggc gct gac ctg gtc atc ggc tcg cgc tac gtg cca ggc ggc cgc gta 499Gly Ala Asp Leu Val Ile Gly Ser Arg Tyr Val Pro Gly Gly Arg Val

120 125 130gtc aac tgg ccc aag aac cgt tgg ctc ttg tcc aag ggc ggc aac gtc 547Val Asn Trp Pro Lys Asn Arg Trp Leu Leu Ser Lys Gly Gly Asn Val

135 140 145tac atc agc gtc gcg ctc ggc gcc ggc ttg acc gat atg acc gca ggg 595Tyr Ile Ser Val Ala Leu Gly Ala Gly Leu Thr Asp Met Thr Ala Gly150 155 160 165tac cgc gct ttt cga cgt gaa gtg cta gaa gca ctg ccg ctt gat gag643Tyr Arg Ala Phe Arg Arg Glu Val Leu Glu Ala Leu Pro Leu Asp Glu

170 175 180ctc tcc aac gct ggg tac att ttc caa gtt gag att gcc tac cgt gca 691Leu Ser Asn Ala Gly Tyr Ile Phe Gln Val Glu Ile Ala Tyr Arg Ala

185 190 195gtt gaa gcc gga ttc gat gtt cgt gaa gtt ccc atc act ttc acc gag 739Val Glu Ala Gly Phe Asp Val Arg Glu Val Pro Ile Thr Phe Thr Glu

200 205 210cgt gag atc ggc gaa tcc aag ctg gac ggc agc ttt gtc aag gat tcc 787Arg Glu Ile Gly Glu Ser Lys Leu Asp Gly Ser Phe Val Lys Asp Ser

215 220 225ctg ctc gag gta acc aag tgg ggc ctc aag cac cgc ggt ggc cag gcc 835Leu Leu Glu Val Thr Lys Trp Gly Leu Lys His Arg Gly Gly Gln Ala230 235 240 245aag gaa ctg tcc aag gaa atg gtc ggc ctg ctg aac tat gag tgg aag 883Lys Glu Leu Ser Lys Glu Met Val Gly Leu Leu Asn Tyr Glu Trp Lys

250 255 260cac ttc aaa aag cgc aac acc tgg ctc taaactgctt gccggttagt 930His Phe Lys Lys Arg Asn Thr Trp Leu

265270 gaa 933<210>676<211>270<212>PRT<213>Corynebacterium glutamicum (Corynebacterium glutamicum)<400>676Met Ser Ser Glu Ala Val Asp Ala Thr Thr Leu Val Ile Ile Pro Thr 151015 Tyr Asn Glu Leu Glu Asn Leu Pro Leu Ile Val Asp Arg Val Arg Thr

20 25 30Ala Thr Pro Asp Val His Val Leu Ile Val Asp Asp Asn Ser Pro Asp

35 40 45Gly Thr Gly Glu Arg Ala Asp Lys Leu Ala Ala Asp Asp Asp His Ile

50 5560Phe Val Leu His Arg Glu Gly Lys Gly Gly Leu Cys Ala Glu Tyr Met 65 70 75 80Ala Gly Phe Gln Trp Gly Leu Glu Arg Asp Tyr Gln Val Leu Cys Glu

85 90 95Met Asp Ala Asp Gly Ser His Ala Pro Glu Gln Leu His Leu Leu Leu

100 105 110Ala Glu Ile Thr Asn Gly Ala Asp Leu Val Ile Gly Ser Arg Tyr Val

115 120 125Pro Gly Gly Arg Val Val Asn Trp Pro Lys Asn Arg Trp Leu Leu Ser

130 135 140Lys Gly Gly Asn Val Tyr Ile Ser Val Ala Leu Gly Ala Gly Leu Thr145 150 155 160Asp Met Thr Ala Gly Tyr Arg Ala Phe Arg Arg Glu Val Leu Glu Ala

165 170 175Leu Pro Leu Asp Glu Leu Ser Asn Ala Gly Tyr Ile Phe Gln Val Glu

180 185 190Ile Ala Tyr Arg Ala Val Glu Ala Gly Phe Asp Val Arg Glu Val Pro

195 200 205Ile Thr Phe Thr Glu Arg Glu Ile Gly Glu Ser Lys Leu Asp Gly Ser

210 215 220Phe Val Lys Asp Ser Leu Leu Glu Val Thr Lys Trp Gly Leu Lys His225 230 235 240Arg Gly Gly Gln Ala Lys Glu Leu Ser Lys Glu Met Val Gly Leu Leu

245 250 255Asn Tyr Glu Trp Lys His Phe Lys Lys Arg Asn Thr Trp Leu

260 265 270

Claims (38)

1. An isolated nucleic acid molecule from Corynebacterium glutamicum (Corynebacterium glutamicum) encoding an MCT protein, or a portion thereof, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1.

2. The isolated nucleic acid molecule of claim 1, wherein the nucleic acid molecule encodes an MCT protein involved in the production of a fine chemical.

3. An isolated corynebacterium glutamicum nucleic acid molecule selected from the group consisting of those sequences set forth as odd-numbered SEQ ID NOs of the sequence listing, or a portion thereof, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in table 1.

4. An isolated nucleic acid molecule encoding a polypeptide sequence selected from the group consisting of those sequences set forth as even-numbered SEQ ID NOs of the sequence Listing, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1.

5. An isolated nucleic acid molecule encoding a naturally occurring allelic variant of a polypeptide selected from the group consisting of the amino acid sequences of the sequences set forth as even-numbered SEQ ID NOs of the sequence Listing, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1.

6. An isolated nucleic acid molecule comprising a nucleotide sequence having at least 50% homology to a nucleotide sequence selected from the group consisting of those sequences set forth as odd-numbered SEQ ID NOs of the sequence Listing, or a portion thereof, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1.

7. An isolated nucleic acid molecule comprising a fragment of at least 15 nucleotides of a nucleic acid comprising a nucleotide sequence selected from the group consisting of those sequences set forth as odd-numbered SEQ ID NOs of the sequence Listing, provided that the nucleic acid molecule does not consist of any of the F-designated genes set forth in Table 1.

8. An isolated nucleic acid molecule which hybridizes to the nucleic acid molecule of any one of claims 1-7 under stringent conditions.

9. An isolated nucleic acid molecule comprising the nucleic acid molecule of any one of claims 1-8, or a portion thereof, and a nucleotide sequence encoding a heterologous polypeptide.

10. A vector comprising the nucleic acid molecule of any one of claims 1-9.

11. The vector of claim 10, which is an expression vector.

12. A host cell transfected with the expression vector of claim 11.

13. The host cell of claim 12, wherein said cell is a microorganism.

14. The host cell of claim 13, wherein the cell belongs to the genus Corynebacterium (Corynebacterium) or Brevibacterium (Brevibacterium).

15. The host cell of claim 12, wherein expression of said nucleic acid molecule results in modulation of the production ofthe fine chemical by said cell.

16. The host cell of claim 15, wherein said fine chemical is selected from the group consisting of: organic acids, proteinogenic and non-proteinogenic amino acids, purine and pyrimidine bases, nucleosides, nucleotides, lipids, saturated and unsaturated fatty acids, diols, sugars, aromatics, vitamins, cofactors, polyketides and enzymes.

17. A method of producing a polypeptide, the method comprising culturing the host cell of claim 12 in a suitable medium, whereby the polypeptide is produced.

18. An isolated MCT polypeptide from corynebacterium glutamicum, or a portion thereof.

19. The polypeptide of claim 18, wherein said polypeptide is involved in the yield of production of a fine chemical.

20. An isolated polypeptide comprising an amino acid sequence selected from the group consisting of those sequences set forth as even-numbered SEQ ID NOs of the sequence listing, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in table 1.

21. An isolated polypeptide comprising a naturally occurring allelic variant of a polypeptide comprising an amino acid sequence selected from the group consisting of those sequences set forth as even-numbered SEQ ID NOs of the sequence listing, or a portion thereof, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in table 1.

22. The isolated polypeptide of any one of claims 18-21,further comprising a heterologous amino acid sequence.

23. An isolated polypeptide encoded by a nucleic acid molecule comprising a nucleotide sequence which is at least 50% homologous to a nucleic acid selected from the group consisting of those sequences set forth as odd-numbered SEQ ID NOs of the sequence Listing, provided that the nucleic acid molecule does not consist of any of the F-designated nucleic acid molecules set forth in Table 1.

24. An isolated polypeptide comprising an amino acid sequence which is at least 50% homologous to an amino acid sequence selected from the group consisting of those sequences set forth as even-numbered SEQ id nos of the sequence listing, provided that the amino acid sequence is not encoded by any of the F-designated genes set forth in table 1.

25. A method for producing a fine chemical, which method comprises culturing a cell comprising a vector according to claim 12, whereby said fine chemical is produced.

26. The method of claim 25, wherein said method further comprises the step of recovering said fine chemical from said culture.

27. The method of claim 25, wherein said method further comprises the step of transfecting said cell with the vector of claim 11 to produce a cell containing said vector.

28. The method of claim 25, wherein the cell belongs to the genus corynebacterium or brevibacterium.

29. The method of claim 25, wherein the cell is selected from the group consisting of: corynebacterium glutamicum (Corynebacterium glutamicum), Corynebacterium lividum (Corynebacterium lilium), Corynebacterium acetoacidophilum (Corynebacterium acetoacidophilum), Corynebacterium acetoglutamicum (Corynebacterium acetoglutamicum), Corynebacterium acetoacidophilum (Corynebacterium acetoacidophilum), Corynebacterium glutamicum (Corynebacterium ammoniagenes), Corynebacterium ammoniagenes, Corynebacterium glutamicum (Corynebacterium divaricatum), Brevibacterium flavum, Brevibacterium ammoniagenes (Brevibacterium ammoniagenes), Brevibacterium butyricum, Corynebacterium glutamicum (Corynebacterium divaricatum), Corynebacterium glutamicum (Corynebacterium divaricum), Brevibacterium flavum (Brevibacterium flavum), Brevibacterium flavum (Brevibacterium acidophilum), Brevibacterium glutarum (Brevibacterium glutamicum), Brevibacterium lactofermentum (Corynebacterium flavum), and Brevibacterium lactofermentum).

30. The method of claim 25, wherein expression of said nucleic acid molecule from said vector results in modulation of production of said fine chemical.

31. The method of claim 25, wherein said fine chemical is selected from the group consisting of: organic acids, proteinogenic and non-proteinogenic amino acids, purine and pyrimidine bases, nucleosides, nucleotides, lipids, saturated and unsaturated fatty acids, diols, sugars, aromatics, vitamins, cofactors, polyketides and enzymes.

32. The method of claim 25, wherein said fine chemical is an amino acid.

33. The method of claim 32, wherein the amino acid is selected from the group consisting of: lysine, glutamic acid, glutamine, alanine, aspartic acid, glycine, serine, threonine, methionine, cysteine, valine, leucine, isoleucine, arginine,proline, histidine, tyrosine, phenylalanine, and tryptophan.

34. A method for producing a fine chemical, said method comprising culturing a cell whose genomic DNA has been altered by the inclusion of a nucleic acid molecule of any one of claims 1-9.

35. A method of diagnosing the presence or activity of corynebacterium diphtheriae in a subject, comprising detecting the presence of one or more of SEQ ID NOs 1 through 676 of the sequence listing in the subject, provided that the sequences are not or are not encoded by any of the F-designated sequences set forth in table 1, thereby diagnosing the presence or activity of corynebacterium diphtheriae in the subject.

36. A host cell comprising a nucleic acid molecule selected from the group consisting of the nucleic acid molecules set forth as odd-numbered SEQ id nos of the sequence listing, wherein said nucleic acid molecule is disrupted.

37. A host cell comprising a nucleic acid molecule selected from the group consisting of the nucleic acid molecules set forth as odd-numbered SEQ ID NOs of the sequence listing, wherein said nucleic acid molecule comprises one or more nucleic acid modifications in the sequence set forth as odd-numbered SEQ ID NOs of the sequence listing.

38. A host cell comprising a nucleic acid molecule selected from the group consisting of the nucleic acid molecules set forth as odd-numbered SEQ id nos of the sequence listing, wherein the regulatory region of said nucleic acid molecule is modified relative to the wild-type regulatory region of said nucleic acid molecule.