CN1784242B - 通过小核糖核酸病毒直接介导的溶瘤作用治疗受试者恶性肿瘤的方法 - Google Patents

通过小核糖核酸病毒直接介导的溶瘤作用治疗受试者恶性肿瘤的方法 Download PDF

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CN1784242B
CN1784242B CN2003801098083A CN200380109808A CN1784242B CN 1784242 B CN1784242 B CN 1784242B CN 2003801098083 A CN2003801098083 A CN 2003801098083A CN 200380109808 A CN200380109808 A CN 200380109808A CN 1784242 B CN1784242 B CN 1784242B
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cells
virus
cell
ovarian cancer
infection
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CN1784242A (zh
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D·雪弗伦
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Merck Sharp & Dohme LLC
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Virotago Private Ltd
Viralytics Ltd
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
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    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32311—Enterovirus
    • C12N2770/32332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

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CN2003801098083A 2002-12-18 2003-12-18 通过小核糖核酸病毒直接介导的溶瘤作用治疗受试者恶性肿瘤的方法 Expired - Fee Related CN1784242B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2002953436 2002-12-18
AU2002953436A AU2002953436A0 (en) 2002-12-18 2002-12-18 A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis
PCT/AU2003/001688 WO2004054613A1 (en) 2002-12-18 2003-12-18 A method of treating a malignancy in a subject via direct picornaviral-mediated oncolysis

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CN201110091011.1A Division CN102166228B (zh) 2002-12-18 2003-12-18 通过小核糖核酸病毒直接介导的溶瘤作用治疗受试者恶性肿瘤的方法

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CN1784242A CN1784242A (zh) 2006-06-07
CN1784242B true CN1784242B (zh) 2011-06-08

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CN201110091011.1A Expired - Fee Related CN102166228B (zh) 2002-12-18 2003-12-18 通过小核糖核酸病毒直接介导的溶瘤作用治疗受试者恶性肿瘤的方法

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EP (1) EP1581257B1 (enExample)
JP (2) JP2006517189A (enExample)
KR (1) KR101171295B1 (enExample)
CN (2) CN1784242B (enExample)
AU (1) AU2002953436A0 (enExample)
CA (1) CA2510227C (enExample)
ES (1) ES2463678T3 (enExample)
NZ (1) NZ541230A (enExample)
WO (1) WO2004054613A1 (enExample)
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HK1082194A1 (en) 2006-06-02
JP2006517189A (ja) 2006-07-20
AU2002953436A0 (en) 2003-01-09
CA2510227C (en) 2015-03-31
ZA200505389B (en) 2006-09-27
KR20050115859A (ko) 2005-12-08
US20060134778A1 (en) 2006-06-22
CN1784242A (zh) 2006-06-07
US7485292B2 (en) 2009-02-03
KR101171295B1 (ko) 2012-08-07
EP1581257A1 (en) 2005-10-05
US20100062020A1 (en) 2010-03-11
EP1581257B1 (en) 2014-04-30
ES2463678T3 (es) 2014-05-28
CN102166228B (zh) 2014-02-19
EP1581257A4 (en) 2007-10-17
WO2004054613A1 (en) 2004-07-01
CA2510227A1 (en) 2004-07-01
HK1157657A1 (en) 2012-07-06
CN102166228A (zh) 2011-08-31
NZ541230A (en) 2008-04-30
JP2012046489A (ja) 2012-03-08

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