CN1781545B - 提取草药的方法 - Google Patents
提取草药的方法 Download PDFInfo
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- CN1781545B CN1781545B CN2005101063263A CN200510106326A CN1781545B CN 1781545 B CN1781545 B CN 1781545B CN 2005101063263 A CN2005101063263 A CN 2005101063263A CN 200510106326 A CN200510106326 A CN 200510106326A CN 1781545 B CN1781545 B CN 1781545B
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- water
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- curcumae longae
- extraction
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Classifications
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
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- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Processing Of Solid Wastes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Extraction Or Liquid Replacement (AREA)
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| US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| CN104397869B (zh) | 2003-11-07 | 2016-06-08 | 美国无烟烟草有限责任公司 | 烟草组合物 |
| US10286027B2 (en) | 2005-05-30 | 2019-05-14 | Arjuna Natural Extracts, Ltd. | Sustained release formulations of curcuminoids and method of preparation thereof |
| US10543277B2 (en) | 2005-05-30 | 2020-01-28 | Arjuna Natural Private Limited | Formulation of curcumin with enhanced bioavailability of curcumin and method of preparation and treatment thereof |
| US8859020B2 (en) | 2005-05-30 | 2014-10-14 | Benny Antony | Treatment of alzheimer's with a curcuminoid mixture and essential oil of turmeric having 45% Ar-turmerone |
| US12053438B2 (en) | 2005-05-30 | 2024-08-06 | Arjuna Natural Private Limited | Formulation of curcuminoids with enhanced bioavailability of curcumin, demethoxycurcumin, bisdemethoxycurcumin and method of preparation and uses thereof |
| PT1890546T (pt) | 2005-05-30 | 2019-01-23 | Antony Benny | Método para melhorar a biodisponibilidade da curcumina |
| US9492402B2 (en) | 2005-05-30 | 2016-11-15 | Benny Antony | Formulation of curcuminoids with enhanced bioavailability of curcumin, demethoxycurcumin, bisdemethoxycurcumin and method of preparation and uses thereof |
| US7883728B2 (en) | 2005-05-30 | 2011-02-08 | Arjuna Natural Extracts, Ltd. | Composition to enhance the bioavailability of curcumin |
| KR20090007564A (ko) * | 2006-03-17 | 2009-01-19 | 허발사이언스 싱가포르 피티이 리미티드 | 쿠르쿠마 종을 포함한 추출물 및 이를 수득하는 방법 |
| GB0724963D0 (en) * | 2007-12-21 | 2008-01-30 | Univ Bangor | Method |
| US8436473B2 (en) * | 2009-05-06 | 2013-05-07 | Taiwan Semiconductor Manufacturing Company, Ltd. | Integrated circuits including air gaps around interconnect structures, and fabrication methods thereof |
| CN102100410B (zh) * | 2010-09-15 | 2013-02-06 | 张锐 | 降焦油、止咳、保健用香烟过滤剂 |
| RU2443330C1 (ru) * | 2011-01-27 | 2012-02-27 | Олег Иванович Квасенков | Способ получения некурительного изделия из махорки |
| RU2443329C1 (ru) * | 2011-01-27 | 2012-02-27 | Олег Иванович Квасенков | Способ получения некурительного изделия из махорки |
| RU2450666C1 (ru) * | 2011-02-01 | 2012-05-20 | Олег Иванович Квасенков | Способ получения некурительного изделия из махорки |
| RU2451466C1 (ru) * | 2011-02-18 | 2012-05-27 | Олег Иванович Квасенков | Способ получения некурительного изделия из махорки |
| RU2452307C1 (ru) * | 2011-02-18 | 2012-06-10 | Олег Иванович Квасенков | Способ получения некурительного изделия из махорки |
| RU2451465C1 (ru) * | 2011-02-18 | 2012-05-27 | Олег Иванович Квасенков | Способ получения некурительного изделия из махорки |
| CN102144809B (zh) * | 2011-05-17 | 2012-08-15 | 何金星 | 卷烟添加物的制造方法及其应用 |
| JP5511895B2 (ja) * | 2012-06-07 | 2014-06-04 | アントニイ ベニー | クルクミンの生物学的利用率を向上させるための組成物 |
| TWI660680B (zh) | 2012-11-26 | 2019-06-01 | 美商通路實業集團國際公司 | 抗氧化膳食增補劑及其相關方法 |
| SG11201600751QA (en) * | 2013-08-02 | 2016-02-26 | Sentiens Llc | Compositions and their use for smoking cessation and other treatments |
| WO2015138877A1 (en) * | 2014-03-14 | 2015-09-17 | New Chapter, Inc. | Supplemental food |
| CN103966027B (zh) * | 2014-05-15 | 2016-06-29 | 青岛金智高新技术有限公司 | 一种迷迭香复配提取物的制备方法 |
| US10226066B2 (en) | 2016-03-07 | 2019-03-12 | R.J. Reynolds Tobacco Company | Rosemary in a tobacco blend |
| CN109938391A (zh) * | 2019-03-20 | 2019-06-28 | 福建绿色黄金生物科技有限公司 | 一种茶与薄荷组合物、制备方法及其应用 |
| CN112400992B (zh) * | 2019-08-20 | 2023-08-29 | 昆明芳本生物科技发展有限公司 | 一种坚果与籽类的保护剂和制备方法及其应用 |
| WO2022003726A1 (en) * | 2020-07-01 | 2022-01-06 | Bio Pharma Laboratories Pvt. Ltd. | Antioxidant herbal composition in seamless capsules for cigarette filter application |
| CN111973530B (zh) * | 2020-09-08 | 2023-04-07 | 广州智尚生物科技有限公司 | 一种去屑止痒组合物及其应用 |
| CN112999173B (zh) * | 2021-04-13 | 2022-06-14 | 云南氪莱铂科技有限公司 | 一种功能性加热发烟体的制备方法、加热不燃烧烟支 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1144835A (zh) * | 1995-09-05 | 1997-03-12 | 中国科学院植物研究所 | 从迷迭香植物中提取抗氧化剂的方法 |
| CN1251367A (zh) * | 1999-08-20 | 2000-04-26 | 广州市轻工研究所 | 超临界二氧化碳萃取分离生姜有效成分的方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US83249A (en) | 1868-10-20 | Improved compound tor the cure of dropsy | ||
| US75837A (en) | 1868-03-24 | Improved medical preparation | ||
| US375173A (en) | 1887-12-20 | Medical compound for dyspepsia | ||
| US194379A (en) | 1877-08-21 | Improvement in condition-powders for horses and cattle | ||
| GB189612103A (en) | 1896-06-03 | 1896-07-04 | Henry Samuel Hoar | A New Cough Mixture, to be Taken Inwardly, for the Cure of Asthma, Coughs, and Pulmonary Affections. |
| CH579354A5 (https=) * | 1973-10-26 | 1976-09-15 | Nestle Sa | |
| US4475919A (en) * | 1980-04-28 | 1984-10-09 | Colorcon, Inc. | Colored medicinal tablet, natural color pigment and method for using the pigment in coloring food, drug and cosmetic products |
| JP2903338B2 (ja) * | 1990-09-10 | 1999-06-07 | 丸善製薬株式会社 | カロチノイドの分解防止剤および食品の褪色防止法 |
| US5120558A (en) | 1991-05-01 | 1992-06-09 | Norac Technologies Inc. | Process for the supercritical extraction and fractionation of spices |
| JP3048642B2 (ja) * | 1994-08-03 | 2000-06-05 | エイ・エス・エイ・シー・ファーマシューティカル・インターナショナル，エイ・アイ・イー | ウコンの無極性および極性抽出物の取得方法およびその用途 |
| JPH08119869A (ja) * | 1994-10-26 | 1996-05-14 | Mikimoto Pharmaceut Co Ltd | 活性酸素抑制剤 |
| EP0728421B1 (fr) * | 1995-02-21 | 2002-06-05 | Societe Des Produits Nestle S.A. | Procédé d'extraction d'antioxydants de matière végétale |
| US5612321A (en) * | 1995-06-22 | 1997-03-18 | Hercules Incorporated | Antioxidant grafted polysaccharides |
| JPH09176009A (ja) * | 1995-12-27 | 1997-07-08 | Inahata Koryo Kk | 新規な抗変異原剤及び抗変異原性作用物質 |
| JPH09221410A (ja) * | 1996-02-14 | 1997-08-26 | Noevir Co Ltd | 老化防止用皮膚外用剤 |
| US5916565A (en) | 1996-03-08 | 1999-06-29 | In Clover, Inc. | Product and method for treating joint disorders in vertebrates |
| JPH09309833A (ja) * | 1996-05-22 | 1997-12-02 | Toyo Hakko:Kk | 活性酸素抑制組成物及びその製造方法並びに血圧抑制剤 |
| US5861415A (en) * | 1996-07-12 | 1999-01-19 | Sami Chemicals & Extracts, Ltd. | Bioprotectant composition, method of use and extraction process of curcuminoids |
| JPH1036280A (ja) * | 1996-07-18 | 1998-02-10 | Pola Chem Ind Inc | ヒドロキシラジカル消去剤 |
| US5773075A (en) | 1996-12-13 | 1998-06-30 | Kalamazoo Holdings, Inc. | High temperature countercurrent solvent extraction of Capsicum solids |
| US20010002269A1 (en) | 1997-05-06 | 2001-05-31 | Zhao Iris Ginron | Multi-phase food & beverage |
| US6048533A (en) | 1997-06-30 | 2000-04-11 | Nguyen; Van Bich | Turmeric for treating health ailments |
| US5897865A (en) | 1997-06-30 | 1999-04-27 | Nguyen; Van Bich | Turmeric for treating skin disorders |
| US5829449A (en) | 1997-09-19 | 1998-11-03 | Thione International, Inc. | Smoking products containing antioxidants |
| AUPO990397A0 (en) * | 1997-10-22 | 1997-11-13 | R.P. Scherer Holdings Pty Ltd | Clear solutions of herbal extracts |
| US6119701A (en) | 1998-02-13 | 2000-09-19 | Cerami Consulting Corp. | Methods, agents and devices for removing nucleophilic toxins from tobacco and tobacco smoke |
| JPH11246336A (ja) * | 1998-02-27 | 1999-09-14 | Ichimaru Pharcos Co Ltd | 活性酸素消去剤及び美肌化粧料組成物 |
| US6224871B1 (en) * | 1998-03-11 | 2001-05-01 | Reliv International, Inc. | Dietary supplement for nutritionally promoting healthy joint function |
| EP1100507B1 (en) * | 1998-07-31 | 2007-01-24 | Sacks, Meir S. | Use of a combination comprising a precursor of uric acid and antioxidant for the treatment of neurodegenerative deseases |
| US6123945A (en) * | 1998-08-26 | 2000-09-26 | Takasago International Corporation | Water-soluble anti-oxidation agents |
| CN1076616C (zh) * | 1999-06-07 | 2001-12-26 | 项炜 | 一种纯天然除烟害保健品 |
| AU768189B2 (en) * | 1999-06-15 | 2003-12-04 | Nutri-Logics, Inc. | Nutrient formulations for disease reduction, and related treatment and component screening methods |
| ES2154615B1 (es) * | 1999-09-23 | 2001-11-16 | Asac Compania De Biotecnologia | Nuevas actividades farmacologicas de los extractos del curcuma longa. |
| US6264995B1 (en) * | 1999-10-19 | 2001-07-24 | Thomas Newmark | Herbal composition for reducing inflammation and methods of using same |
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2002
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- 2002-01-30 JP JP2002563787A patent/JP2004524304A/ja active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1144835A (zh) * | 1995-09-05 | 1997-03-12 | 中国科学院植物研究所 | 从迷迭香植物中提取抗氧化剂的方法 |
| CN1251367A (zh) * | 1999-08-20 | 2000-04-26 | 广州市轻工研究所 | 超临界二氧化碳萃取分离生姜有效成分的方法 |
Non-Patent Citations (6)
| Title |
|---|
| 葛发欢，史庆龙，谭晓华，李志远，金雪松.超临界CO2萃取姜黄油的工艺研究.中药材20 7.1997,20(7),345-350页. |
| 葛发欢,史庆龙,谭晓华,李志远,金雪松.超临界CO2萃取姜黄油的工艺研究.中药材20 7.1997,20(7),345-350页. * |
| 葛发欢，李菁，王海波，黄昌全，谢郁峰.超临界CO2萃取技术在黄花蒿成份研究中的应用.中药材17 8.1994,17(8),31-32，56页. |
| 葛发欢,李菁,王海波,黄昌全,谢郁峰.超临界CO2萃取技术在黄花蒿成份研究中的应用.中药材17 8.1994,17(8),31-32,56页. * |
| 高彦祥.食用天然色素超临界二氧化碳提取的研究.中国食品添加剂 2.1995,(2),13-17页. |
| 高彦祥.食用天然色素超临界二氧化碳提取的研究.中国食品添加剂 2.1995,(2),13-17页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60229215D1 (de) | 2008-11-20 |
| TWI239844B (en) | 2005-09-21 |
| CN1781545A (zh) | 2006-06-07 |
| US20050152999A1 (en) | 2005-07-14 |
| WO2002063982A1 (en) | 2002-08-22 |
| US7041321B2 (en) | 2006-05-09 |
| US20050095304A1 (en) | 2005-05-05 |
| EP1357811A4 (en) | 2004-11-24 |
| JP2004524304A (ja) | 2004-08-12 |
| ATE410177T1 (de) | 2008-10-15 |
| CN1221190C (zh) | 2005-10-05 |
| CA2437731A1 (en) | 2002-08-22 |
| US6827951B2 (en) | 2004-12-07 |
| ES2317990T3 (es) | 2009-05-01 |
| KR20030081435A (ko) | 2003-10-17 |
| HK1060834A1 (en) | 2004-08-27 |
| JP2010047593A (ja) | 2010-03-04 |
| CN1491089A (zh) | 2004-04-21 |
| US6982099B2 (en) | 2006-01-03 |
| EP1357811A1 (en) | 2003-11-05 |
| EP1357811B1 (en) | 2008-10-08 |
| AU2002235480B2 (en) | 2008-05-15 |
| US20020136786A1 (en) | 2002-09-26 |
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