CN1775250A - Anti-cancer preparation-kangaiping, new preparing method therefor - Google Patents
Anti-cancer preparation-kangaiping, new preparing method therefor Download PDFInfo
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- CN1775250A CN1775250A CNA2005101159783A CN200510115978A CN1775250A CN 1775250 A CN1775250 A CN 1775250A CN A2005101159783 A CNA2005101159783 A CN A2005101159783A CN 200510115978 A CN200510115978 A CN 200510115978A CN 1775250 A CN1775250 A CN 1775250A
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Abstract
The present invention relates to a Chinese medicine composition and its preparation process. In particular, it relates to a Chinese medicine prescription for curing the malignant tumor of digestive tract, including carcinoma of stomach, cardiac cancer, carcinoma of esophagus and rectal cancer, etc. and its preparation process. It can be made into dripping pills and soft capsule preparation.
Description
Technical field:
The present invention relates to a kind of Chinese medicine composition and preparation technology thereof, particularly a kind of pyretic toxicity blood stasis for the treatment of is stopped up the gastric cancer that stagnates the intestines and stomach and cause, the prescription and the preparation technology thereof of digestive tract tumor such as esophageal carcinoma, carcinoma of gastric cardia, rectal cancer.
Background technology:
Digestive tract cancer especially gastric cancer is one of China's common malignancy, poor prognosis.It is serious crisis human life's disease.The traditional Chinese medical science often adopts heat-clearing and toxic substances removing, and the method for eliminating stasis to stop pain is as one of means for the treatment of this type of disease, and is evident in efficacy.The anticancer pill ball designs at above disease.But in the practice, this medicine is as ordinary pill, and medical material is beaten powder and is used as medicine, and without any extraction, so that impurity is many, dosage is big, has a strong impact on its clinical practice.
The preparation of process extraction process preparation of the present invention is easy to dissolving and absorption than elite and thick putting that ordinary pill more can collect medicine, and curative effect is fast, and administration time is short, and therefore, curative effect is better.
The purpose of this invention is to provide a kind of therapeutic domain wide, easily accept, easily absorb, the preparation technology of efficient, low dosage, the Chinese medicine dripping pills that has no side effect, soft capsule, granule, chewable tablet, capsule, tablet, mixture, its pill that makes can be used for curing mainly the pyretic toxicity blood stasis and stops up the gastric cancer that stagnates the intestines and stomach and cause, digestive tract tumor such as esophageal carcinoma, carcinoma of gastric cardia, rectal cancer.
Summary of the invention:
The present invention relates to a kind of prescription and preparation technology thereof of Chinese medicine preparation, it is characterized in that, the preparation of per 1000 dosage units is prepared from by following proportion raw material:
174～2680 parts of 174～2680 parts of Herba Rabdosiae glaucocalycis of 174～2680 parts of Radix Actinidiae Chinensis of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis)
225～3460 parts of 94～1440 portions of Herba Scutellariae Barbataes of 174～2680 portions of Herba Duchesneae Indicaes of Herba Sarcandrae
94～1440 parts of 94～1440 parts of Herba Selaginellae Doederleiniis of 94～1440 parts of Herba Hedyotidis Diffusaes of Herba Caryopteridis Incanae
0.4～6 part of Venenum Bufonis
Preferably:
1340 parts of 1340 parts of Herba Rabdosiae glaucocalycis of 1340 parts of Radix Actinidiae Chinensis of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis)
1730 parts of 720 portions of Herba Scutellariae Barbataes of 1340 portions of Herba Duchesneae Indicaes of Herba Sarcandrae
720 parts of 720 parts of Herba Selaginellae Doederleiniis of 720 parts of Herba Hedyotidis Diffusaes of Herba Caryopteridis Incanae
3 parts of Venenum Bufoniss
In more than forming, the weight of medicine is calculated with crude drug, and per 1 part can be 1 gram, also can be kilogram or ton, if be unit with gram, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Described 1000 doses of fingers, the final drug preparation of making, as make 1000 of soft capsule preparations, drop pill 1000 balls, granule 1000g etc., also can make big packing as granule, as 100～500 bags, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose 1 time.
More than form, can be made into the preparation of 50～1000 taking doses,, make 125 bags, take 1～2 bag at every turn, can take altogether 62.5～125 times as granule.
More than form to be by weight as proportioning, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be unit with the milligram also, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The raw material of Chinese medicine of said ratio extracts processing through new technology of the present invention, obtain the active constituents of medicine of preparation of the present invention, add suitable excipient as required and make suitable medicinal any dosage form, said preparation can be drop pill, soft capsule, granule, chewable tablet, mixture.
The above new technology of the present invention may further comprise the steps:
(1) preparation of Bufo siccus active component: get Bufo siccus and be ground into coarse powder, add an amount of ethanol earlier and run through, in the percolator of packing into, add 3～12 times of amount 6～95% soak with ethanol and carry out percolation after 3～12 hours, percolation to effluent is a light color, collect percolate, reclaim under reduced pressure is finished ethanol, adds the dissolve with ethanol of 0.5～5 times of amount, the decolorizing with activated carbon of adding 0.5～1.0%, after decarburization, filter, having reclaimed behind the ethanol must the Bufo siccus active component;
(2) get the residue medical material, decoct with water 2～6 times, each 0.5～3 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 60～95% ethanol of 3～15 times of amounts, stirred, and left standstill, and deepfreeze 3～60h filters, and filtrate is condensed into thick paste;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
The active constituents of medicine of the preparation of the present invention that above method obtains can be prepared into preparation of the present invention through further processing.
Preparation of the present invention, different dosage form method difference below is the preparation method of several preferred dosage form.
(1) preparation of drop pill
Drop pill of the present invention, wherein the ratio of active component and adjuvant is 1: 0.5～10, and preferred ratio is 1: 2～4, and most preferred ratio is 1: 3.The above adjuvant be specially molecular weight polyethylene glycol between 400 to 10000 Polyethylene Glycol and their mixture, as PEG400 (PEG400), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture or other suitable other auxiliary elements of making drop pill, as glycerol, gelatin or stearic acid sodium etc.
Following steps are taked in the preparation of drop pill of the present invention:
1. be ready to following raw material: active component, adjuvant and/or other inactive ingredients;
2. with the above-mentioned raw materials mix homogeneously;
3. add the transconversion into heat material, move into the drip irrigation of drop pill machine, medicinal liquid splashes in the liquid sub liquid paraffin by water dropper, removes liquid paraffin, selects ball, promptly.
(2) preparation of soft capsule
Soft capsule preparation of the present invention is that active component and pharmaceutically useful organic solvent and the material of making soft capsule shell are formed.Organic solvent wherein is selected from PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, the material of wherein making soft capsule shell is gelatin or arabic gum, water, plasticizer and antiseptic, the weight ratio of gelatin or arabic gum and plasticizer is 1.0: 0.4～1.0 in the soft capsule shell, and the weight ratio of gelatin and water is 1.0: 0.8～1.2; The content of active component is 50mg～500mg in every soft capsule.
The preparation method of preparation of the present invention, the process following steps:
A. get gelatin, glycerol, pure water adds thermosol, adds an amount of antiseptic, preparation rubber;
B. get active component and be dissolved in organic solvent, add suitable quantity of water, be prepared into soft capsule through encapsulating machine.
(3) preparation process of granule is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, promptly get granule.
(4) preparation method of chewable tablet is as follows: with the gained active component, add a certain amount of correctives, filler, lubricant, granulate, and drying, tabletting promptly gets chewable tablet.
Filler described in the preparation of granule, chewable tablet is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
Following data declaration beneficial effect of the present invention by experiment:
In order to prove the Clinical feasibility that changes after the technology, we have carried out its main pharmacodynamics, toxicologic study to this medicine, observe its therapeutical effect, and the clinical experimental basis that provides is provided.
1, to mice S
180Sarcoma and hepatocarcinoma H
22The influence of solid tumor:
30 of Kunming mouses, age in days 40～50d (body weight 18～22g), male and female dual-purpose.Under sterilising conditions, get the mice S that goes down to posterity respectively
180Sarcoma and hepatocarcinoma H
22Solid tumor tumor liquid is with normal saline 1: 4 dilution, and it is subcutaneous that every 0.2ml injects the right axil of mice, the 24h administration of divide into groups, prescription extractum group (0.27g/kg), every day 1 time, continuous 10d; Positive controls lumbar injection (ip) cyclophosphamide 15mg/kg, ig distilled water simultaneously; Matched group ig distilled water.Put to death mice next day after the last administration, peels off the tumor piece and weigh, and calculates average tumour inhibiting rate, analyzes with t value method, the results are shown in Table 1.
Table 1 couple lotus tumor (S
180, H
22) influence of mouse tumor bulk-growth
| Group | Average tumor weight (g, x ± s) | Average tumour inhibiting rate (%) |
| S 180 | H 22 | S 180 | H 22 | |
| Matched group (water) cyclophosphamide prescription extractum group | 1.91±0.54 1.24±0.35 * 1.20±0.81 * | 1.50±0.91 0.81±0.24 * 0.78±0.35 * | - 35.1 37.1 | - 46.0 48.0 |
Annotate: compare with matched group,
*P＜0.05,
*P＜0.01, down together; (n=10)
2, to the tumor-bearing mice Immune Effects
Get mice H
22Tumor liquid, inoculation tumor liquid and grouping medication are the same.Successive administration 10d, 1h after the last administration, every caudal vein is injected 10% india ink, gets hematometry blood carbon clearance speed index (K) from eye socket respectively in injection back 2 and 10min.Analyze with t value method.The result: prescription extractum group (average K value is 0.0211 ± 0.0060) can strengthen tumor-bearing mice reticuloendothelial system phagocytic function, and the carbon granules clearance rate is apparently higher than matched group (0.0157 ± 0.0021), and difference has significance meaning (P＜0.05); Cyclophosphamide group (0.00983 ± 0.00379) significantly suppresses mice endothelial system phagocytic function, and difference has significance meaning (P＜0.01).
3, to the influence of tumor-bearing mice stress ability
Get 30 of 18～22g Kunming mouses, divide equally 3 groups, 10 every group, inoculate H respectively
221: 4 dilution tumor liquid, the administration of dividing into groups next day was pressed last method continuous 7 days, 1h after the last administration, mice is put the people respectively and fills sealing observation in the 10g sodica calx 250ml wide mouthed bottle, and the record mice is at normobaric hypoxia following time-to-live of situation (min).The result: (mean survival time 48.0 ± 12.4min) all can prolong the tumor-bearing mice following time-to-live of normobaric hypoxia to prescription extractum group, and (35.5 ± 9.1min) relatively, analyzes through t value method, and difference has significance meaning (P＜0.05) with the water matched group.Cyclophosphamide group (the no significance meaning of 34.3 ± 4.8min) effects.
4, toxicological study
Acute toxicity test shows that rat oral gavage extract of the present invention fails to measure LD
50
Long term toxicity test: rat grouping, extract of the present invention is irritated stomach, every day three times, connect and annotate 90d, the result, administration group rat and control rats movable, search for food, drinking-water, body weight and multinomial observation indexs such as substantial viscera pathologic finding and histopathology detect, result of the test is not all found any toxicity; Hemogram and hepatic and renal function index and the equal no significant difference of matched group.
The blood vessel irritation of this medicine, allergy and hemolytic test all are negative.
In sum, preparation of the present invention, dropping pill formulation particularly of the present invention and soft capsule preparation are that a kind of good treatment pyretic toxicity blood stasis is stopped up the gastric cancer that stagnates the intestines and stomach and cause, the medicine of digestive tract tumor such as esophageal carcinoma, carcinoma of gastric cardia, rectal cancer, and change preparation technology, can obviously strengthen its promoting blood flow to regulate menstruation, clinical efficacies such as inducing diuresis to remove edema, its hypotoxicity in addition, prolonged application safety, therefore, be worth clinical application.
The specific embodiment:
Further specify the present invention by the following examples, include but not limited to the following example.
Embodiment 1:
The preparation method of drop pill of the present invention:
Prescription:
Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 174g Radix Actinidiae Chinensis 174g Herba Rabdosiae glaucocalycis 174g
Herba Sarcandrae 174g Herba Duchesneae Indicae 94g Herba Scutellariae Barbatae 225g
Herba Caryopteridis Incanae 94g Herba Hedyotidis Diffusae 94g Herba Selaginellae Doederleinii 94g
Venenum Bufonis 0.4g
PEG4000 100g
Make 1000 balls
Preparation method:
(1) preparation of Bufo siccus active component: get Bufo siccus and be ground into coarse powder, add an amount of ethanol earlier and run through, in the percolator of packing into, add 6 times of amount 75% soak with ethanol and carry out percolation after 3 hours, percolation to effluent is a light color, collect percolate, reclaim under reduced pressure is finished ethanol, adds the dissolve with ethanol of 1 times of amount, the decolorizing with activated carbon of adding 0.5%, after decarburization, filter, having reclaimed behind the ethanol must the Bufo siccus active component;
(2) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 95% ethanol of 10 times of amounts, stirred, and left standstill, and deepfreeze 12h filters, and filtrate is condensed into thick paste;
(3) with above-mentioned extract obtained, the PEG4000 that adds recipe quantity puts into the vessel in heating dissolving, and jolting makes and dissolves into uniform solution, inserts in the fluid reservoir.Keep 80 ℃ the system of dripping temperature, and a control speed, condensed fluid is a liquid paraffin, drips system promptly.
Embodiment 2:
Preparation of soft capsule method of the present invention:
Prescription:
Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 737g Radix Actinidiae Chinensis 737g Herba Rabdosiae glaucocalycis 737g
Herba Sarcandrae 737g Herba Duchesneae Indicae 720g Herba Scutellariae Barbatae 952g
Herba Caryopteridis Incanae 396g Herba Hedyotidis Diffusae 396g Herba Selaginellae Doederleinii 396g
Venenum Bufonis 1.7g
PEG400 460g
Make 1000
Preparation method:
(1) preparation of Bufo siccus active component: get Bufo siccus and be ground into coarse powder, add an amount of ethanol earlier and run through, in the percolator of packing into, add 6 times of amount 75% soak with ethanol and carry out percolation after 3 hours, percolation to effluent is a light color, collect percolate, reclaim under reduced pressure is finished ethanol, adds the dissolve with ethanol of 1 times of amount, the decolorizing with activated carbon of adding 0.5%, after decarburization, filter, having reclaimed behind the ethanol must the Bufo siccus active component;
(2) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 95% ethanol of 10 times of amounts, stirred, and left standstill, and deepfreeze 12h filters, and filtrate is condensed into thick paste;
(3) with above-mentioned extract obtained, add an amount of PEG400 and mix and mixing, add the PEG400 of surplus then, promptly get medicinal liquid.It is standby in addition to join gelatin solution by certain prescription.The condition that control is suitable is regulated content weight, obtains soft capsule in the soft capsule machine.
Embodiment 3:
The preparation method of granule of the present invention:
Prescription:
Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 1340g Radix Actinidiae Chinensis 1340g Herba Rabdosiae glaucocalycis 1340g
Herba Sarcandrae 1340g Herba Duchesneae Indicae 720g Herba Scutellariae Barbatae 1730g
Herba Caryopteridis Incanae 720g Herba Hedyotidis Diffusae 720g Herba Selaginellae Doederleinii 720g
Venenum Bufonis 3g
Make 1000g
Preparation method:
(1) preparation of Bufo siccus active component: get Bufo siccus and be ground into coarse powder, add an amount of ethanol earlier and run through, in the percolator of packing into, add 6 times of amount 75% soak with ethanol and carry out percolation after 3 hours, percolation to effluent is a light color, collect percolate, reclaim under reduced pressure is finished ethanol, adds the dissolve with ethanol of 1 times of amount, the decolorizing with activated carbon of adding 0.5%, after decarburization, filter, having reclaimed behind the ethanol must the Bufo siccus active component;
(2) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 95% ethanol of 10 times of amounts, stirred, and left standstill, and deepfreeze 12h filters, and filtrate is condensed into thick paste;
(3) above active component is merged, add aspartame 5.0g, dextrin 200.0g, granulate, drying sprays into essence 5.0g, promptly gets granule 1000g.
Embodiment 4:
The preparation method of chewable tablet of the present invention:
Prescription:
Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis) 375g Radix Actinidiae Chinensis 375g Herba Rabdosiae glaucocalycis 375g
Herba Sarcandrae 375g Herba Duchesneae Indicae 720g Herba Scutellariae Barbatae 484g
Herba Caryopteridis Incanae 202g Herba Hedyotidis Diffusae 202g Herba Selaginellae Doederleinii 202g
Venenum Bufonis 0.8g
Make 1000
Preparation method:
(1) preparation of Bufo siccus active component: get Bufo siccus and be ground into coarse powder, add an amount of ethanol earlier and run through, in the percolator of packing into, add 6 times of amount 75% soak with ethanol and carry out percolation after 3 hours, percolation to effluent is a light color, collect percolate, reclaim under reduced pressure is finished ethanol, adds the dissolve with ethanol of 1 times of amount, the decolorizing with activated carbon of adding 0.5%, after decarburization, filter, having reclaimed behind the ethanol must the Bufo siccus active component;
(2) get the residue medical material, decoct with water 3 times, each 1 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 95% ethanol of 10 times of amounts, stirred, and left standstill, and deepfreeze 12h filters, and filtrate is condensed into thick paste;
(3) above active component is merged, add aspartame 3.0g, mannitol 180.0g, granulation, drying adds magnesium stearate 3.0g, mixing, and tabletting promptly gets 1000 of chewable tablet.
Claims (10)
1, a kind of Chinese medicine preparation is characterized in that per 1000 dosage units are made by the following weight proportion raw material:
174～2680 parts of 174～2680 parts of Herba Rabdosiae glaucocalycis of 174～2680 parts of Radix Actinidiae Chinensis of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis)
225～3460 parts of 94～1440 portions of Herba Scutellariae Barbataes of 174～2680 portions of Herba Duchesneae Indicaes of Herba Sarcandrae
94～1440 parts of 94～1440 parts of Herba Selaginellae Doederleiniis of 94～1440 parts of Herba Hedyotidis Diffusaes of Herba Caryopteridis Incanae
0.4～6 part of Venenum Bufonis.
2, the compound preparation of claim 1 is characterized in that, per 1000 dosage units are made by the following weight proportion raw material:
1340 parts of 1340 parts of Herba Rabdosiae glaucocalycis of 1340 parts of Radix Actinidiae Chinensis of Herba Lysimachiae Clethroids (Radix Seu Herba Lysimachiae Clethroidis)
1730 parts of 720 portions of Herba Scutellariae Barbataes of 1340 portions of Herba Duchesneae Indicaes of Herba Sarcandrae
720 parts of 720 parts of Herba Selaginellae Doederleiniis of 720 parts of Herba Hedyotidis Diffusaes of Herba Caryopteridis Incanae
3 parts of Venenum Bufoniss.
3, claim 1 or any one Chinese medicine preparation of 2 are various suitable dosage forms such as drop pill, soft capsule, granule, chewable tablet, mixture, hard capsule.
4, the Chinese medicine preparation of claim 3 through described raw material is extracted processing, obtains active component, adds suitable adjuvant as required and makes.
5, the Chinese medicine preparation of claim 4 is characterized in that, described active component prepares through following steps:
(1) preparation of Bufo siccus active component: get Bufo siccus and be ground into coarse powder, add an amount of ethanol earlier and run through, in the percolator of packing into, add 3～12 times of amount 60～95% soak with ethanol and carry out percolation after 3～12 hours, percolation to effluent is a light color, collect percolate, reclaim under reduced pressure is finished ethanol, adds the dissolve with ethanol of 0.5～5 times of amount, the decolorizing with activated carbon of adding 0.5～1.0%, after decarburization, filter, having reclaimed behind the ethanol must the Bufo siccus active component;
(2) get the residue medical material, decoct with water 2～6 times, each 0.5～3 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 60～95% ethanol of 3～15 times of amounts, stirred, and left standstill, and deepfreeze 3～60h filters, and filtrate is condensed into thick paste;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
6, the Chinese medicine preparation of claim 5 is characterized in that:
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
7, the Chinese medicine preparation of claim 5 is characterized in that:
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: with active constituents of medicine and proper auxiliary materials mix homogeneously, obtain uniform suspension and/or solution, regulate content weight, compacting, dry getting final product.
8, the Chinese medicine preparation of claim 5 is characterized in that:
The preparation process of described granule is as follows: with above-mentioned extract obtained, add a certain amount of filler, correctives, lubricant, granulate, promptly get granule;
The preparation method of chewable tablet is as follows: with above-mentioned extract obtained, adds a certain amount of filler, correctives, lubricant, granulates, and drying, tabletting promptly gets chewable tablet.
9, the Chinese medicine preparation of claim 8 is characterized in that:
Described filler is selected from one or more the mixture in lactose, sucrose, dextrin, starch, microcrystalline Cellulose, mannitol, pregelatinized Starch, sorbitol, the xylitol etc.;
Described correctives one of is selected from Rhizoma et radix valerianae, Fructus Pruni pseudocerasi, Fructus Vitis viniferae, Fructus Citri tangerinae, Fructus Citri Limoniae, Herba Menthae, Fructus Fragariae Ananssae, Fructus Musae, Fructus Ananadis comosi, honey peach essence, maltose alcohol, saccharin sodium, protein sugar, sucrose, aspartame, the stevioside or wherein several mixture;
Suitable lubricant comprises wherein one or more such as magnesium stearate, Pulvis Talci, micropowder silica gel.
10, the preparation method of any one Chinese medicine preparation of claim 1～9 is characterized in that, the process following steps:
Described raw material of Chinese medicine is extracted processing, obtain active component, add suitable adjuvant and make; Wherein said active component prepares through following steps:
(1) preparation of Bufo siccus active component: get Bufo siccus and be ground into coarse powder, add an amount of ethanol earlier and run through, in the percolator of packing into, add 3～12 times of amount 60～95% soak with ethanol and carry out percolation after 3～12 hours, percolation to effluent is a light color, collect percolate, reclaim under reduced pressure is finished ethanol, adds the dissolve with ethanol of 0.5～5 times of amount, the decolorizing with activated carbon of adding 0.5～1.0%, after decarburization, filter, having reclaimed behind the ethanol must the Bufo siccus active component;
(2) get the residue medical material, decoct with water 2～6 times, each 0.5～3 hour, collecting decoction filtered, and filtrate is condensed into certain volume, added 60～95% ethanol of 3～15 times of amounts, stirred, and left standstill, and deepfreeze 3～60h filters, and filtrate is condensed into thick paste;
(3) above active component lumps together the active constituents of medicine into preparation of the present invention, and this active component is suitable for preparing various preparations such as drop pill of the present invention and soft capsule.
Described drop pill, wherein the ratio of active component and adjuvant is 1: 0.5～10, described adjuvant be molecular weight between 400 to 10000 Polyethylene Glycol and their mixture, be selected from PEG400 (or 600), Macrogol 2000, Macrogol 4000, polyethylene glycol 6000 or their mixture.
Its preparation method is: active constituents of medicine and proper auxiliary materials behind 60～115 ℃ of mix homogeneously, are regulated the water dropper size with control drop pill weight, are that the coolant system of dripping forms with dimethicone or liquid paraffin, and coolant temperature is-10～5 ℃.
Described soft capsule, its content is made up of active component and suitable substrate, and wherein the content of active component is 50mg～500mg in every soft capsule; Substrate wherein is selected from wherein one or more of PEG400, Tween 80, glycerol, propylene glycol, isopropyl alcohol, dehydrogenation soybean oil, vegetable oil, aromatic oil, animal wet goods.
Its preparation method is: active constituents of medicine is mixed with proper auxiliary materials.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2005101159783A CN1775250A (en) | 2005-11-18 | 2005-11-18 | Anti-cancer preparation-kangaiping, new preparing method therefor |
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| CNA2005101159783A CN1775250A (en) | 2005-11-18 | 2005-11-18 | Anti-cancer preparation-kangaiping, new preparing method therefor |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491192A (en) * | 2014-12-03 | 2015-04-08 | 姚娟 | Medicinal preparation for anti-cancer pill and preparation method of medicinal preparation |
| CN105233083A (en) * | 2015-10-26 | 2016-01-13 | 钮韵雯 | Antitumor teat used for clearing heat, expelling toxin and improving immunity and preparation method thereof |
-
2005
- 2005-11-18 CN CNA2005101159783A patent/CN1775250A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491192A (en) * | 2014-12-03 | 2015-04-08 | 姚娟 | Medicinal preparation for anti-cancer pill and preparation method of medicinal preparation |
| CN104491192B (en) * | 2014-12-03 | 2019-02-01 | 姚娟 | A kind of pharmaceutical preparation of anticancer pill and preparation method thereof |
| CN105233083A (en) * | 2015-10-26 | 2016-01-13 | 钮韵雯 | Antitumor teat used for clearing heat, expelling toxin and improving immunity and preparation method thereof |
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