CN1774431B - 从天然原料中分离和提纯紫杉醇的方法 - Google Patents

从天然原料中分离和提纯紫杉醇的方法 Download PDF

Info

Publication number
CN1774431B
CN1774431B CN2004800097904A CN200480009790A CN1774431B CN 1774431 B CN1774431 B CN 1774431B CN 2004800097904 A CN2004800097904 A CN 2004800097904A CN 200480009790 A CN200480009790 A CN 200480009790A CN 1774431 B CN1774431 B CN 1774431B
Authority
CN
China
Prior art keywords
taxol
acetone
solution
mixture
silica gel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2004800097904A
Other languages
English (en)
Chinese (zh)
Other versions
CN1774431A (zh
Inventor
T·拜-卡克
M·伯蒂尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chaichem Pharmaceuticals International Inc
Original Assignee
Chaichem Pharmaceuticals International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chaichem Pharmaceuticals International Inc filed Critical Chaichem Pharmaceuticals International Inc
Publication of CN1774431A publication Critical patent/CN1774431A/zh
Application granted granted Critical
Publication of CN1774431B publication Critical patent/CN1774431B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
CN2004800097904A 2003-02-27 2004-01-27 从天然原料中分离和提纯紫杉醇的方法 Expired - Fee Related CN1774431B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/375,474 2003-02-27
US10/375,474 US6759539B1 (en) 2003-02-27 2003-02-27 Process for isolation and purification of paclitaxel from natural sources
PCT/CA2004/000107 WO2004076435A1 (en) 2003-02-27 2004-01-27 Improved process for isolation and purification of paclitaxel from natural sources

Publications (2)

Publication Number Publication Date
CN1774431A CN1774431A (zh) 2006-05-17
CN1774431B true CN1774431B (zh) 2011-03-23

Family

ID=32594996

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2004800097904A Expired - Fee Related CN1774431B (zh) 2003-02-27 2004-01-27 从天然原料中分离和提纯紫杉醇的方法

Country Status (9)

Country Link
US (1) US6759539B1 (https=)
EP (1) EP1608636B1 (https=)
JP (1) JP4563994B2 (https=)
KR (1) KR101114982B1 (https=)
CN (1) CN1774431B (https=)
AT (1) ATE382613T1 (https=)
CA (1) CA2516811C (https=)
DE (1) DE602004011034T2 (https=)
WO (1) WO2004076435A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR054215A1 (es) * 2006-01-20 2007-06-13 Eriochem Sa Una formulacion farmaceutica de un taxano, una composicion solida de un taxano liofilizado a partir de una solucion de acido acetico, un procedimiento para la preparacion de dicha composicion solida de un taxano, una composicion solubilizante de un taxano liofilizado, y un conjunto de elementos (kit
KR101455694B1 (ko) * 2012-09-18 2014-11-03 학교법인 선목학원 에틸아세테이트 및 아세토니트릴의 유기용매 혼합액을 이용한 액체-액체 추출법을 포함하는 약물 검출법
KR101381502B1 (ko) * 2012-09-28 2014-04-04 공주대학교 산학협력단 파클리탁셀의 정제방법
CN103877600B (zh) * 2014-03-27 2017-04-05 沈祖鸿 含有红豆杉提取物的喷雾剂及其制造方法和制造配方
CN104031008B (zh) * 2014-06-30 2015-12-09 牛兆颖 一种紫杉醇粗提物的制备方法
CN108101869A (zh) * 2017-12-20 2018-06-01 上海金和生物制药有限公司 一种天然紫杉醇的提取方法
CN109384749A (zh) * 2018-12-26 2019-02-26 重庆市碚圣医药科技股份有限公司 一种紫杉醇的纯化方法
CN110845451A (zh) * 2019-11-28 2020-02-28 云南皓瑞逸生物科技有限公司 一种从红豆杉中提取紫杉醇的方法
CN112521349B (zh) * 2020-11-11 2023-04-07 福建齐衡科技有限公司 一种紫杉醇的纯化方法
CN116829203A (zh) * 2020-11-16 2023-09-29 亨莫特克股份公司 涂覆的医疗产品

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6452024B1 (en) * 2000-02-22 2002-09-17 Chaichem Pharmaceuticals International Process for extraction and purification of paclitaxel from natural sources

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601676B1 (fr) 1986-07-17 1988-09-23 Rhone Poulenc Sante Procede de preparation du taxol et du desacetyl-10 taxol
FR2629818B1 (fr) 1988-04-06 1990-11-16 Centre Nat Rech Scient Procede de preparation du taxol
US5019504A (en) 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
US5175315A (en) 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
MY110249A (en) 1989-05-31 1998-03-31 Univ Florida State Method for preparation of taxol using beta lactam
US5015744A (en) 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5136060A (en) 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5475120A (en) 1990-11-02 1995-12-12 University Of Florida Method for the isolation and purification of taxol and its natural analogues
US5380916A (en) 1990-11-02 1995-01-10 University Of Florida Method for the isolation and purification of taxane derivatives
US5312740A (en) 1991-02-12 1994-05-17 Nippon Steel Corporation Process for producing taxol by cell culture of taxus species
EP0580759B1 (en) 1991-04-19 1999-05-26 The University Of Mississippi Methods and compositions for isolating taxanes
CA2072400C (en) 1991-07-05 2003-08-19 Jayaprakash B. Nair Supercritical extraction of taxanes
IT1258838B (it) 1992-01-31 1996-02-29 Indena Spa Processo per l'estrazione di tassolo e derivati da cultivar del genere taxus
US5445809A (en) 1992-03-03 1995-08-29 Research And Development Institute At Montana State University Production of taxol from the yew tree
US5451392A (en) 1992-03-03 1995-09-19 The Research And Development Institute At Montana State University Production of taxol
US5200534A (en) 1992-03-13 1993-04-06 University Of Florida Process for the preparation of taxol and 10-deacetyltaxol
CA2434692A1 (en) 1992-04-07 1993-10-08 Paul M. Cino Callus cell induction and the preparation of taxanes
US5322779A (en) 1992-04-16 1994-06-21 The Research And Development Institute, Inc. At Montana State University Taxol production by taxomyces andreanae
CA2130578A1 (en) 1992-04-17 1993-10-28 Geewananda P. Gunawardana Taxol derivatives
GB9213077D0 (en) 1992-06-19 1992-08-05 Erba Carlo Spa Polymerbound taxol derivatives
US5470866A (en) 1992-08-18 1995-11-28 Virginia Polytechnic Institute And State University Method for the conversion of cephalomannine to taxol and for the preparation of n-acyl analogs of taxol
US5684169A (en) 1992-11-27 1997-11-04 Ensuiko Sugar Refining Co., Ltd. Cyclodextrin inclusion complex of taxol, and method for its production and its use
US5380751A (en) 1992-12-04 1995-01-10 Bristol-Myers Squibb Company 6,7-modified paclitaxels
WO1994013827A1 (en) * 1992-12-07 1994-06-23 Michigan State University PROCESS FOR THE ISOLATION AND PURIFICATION OF TAXOL AND TAXANES FROM TAXUS spp
US5279949A (en) * 1992-12-07 1994-01-18 Board Of Trustees Operating Michigan State University Process for the isolation and purification of taxol and taxanes from Taxus spp
ATE253563T1 (de) 1993-02-05 2003-11-15 Bryn Mawr College Synthese von taxol, seinen analogen und intermediaten mit variablen a-ring seitenketten
US5703247A (en) 1993-03-11 1997-12-30 Virginia Tech Intellectual Properties, Inc. 2-Debenzoyl-2-acyl taxol derivatives and methods for making same
US5440055A (en) 1993-03-12 1995-08-08 Aphios Corporation Method and apparatus for extracting taxol from source materials
US5516676A (en) 1993-06-15 1996-05-14 Bristol-Myers Squibb Company Preparation of C-13 hydroxyl-bearing taxanes using nocardioides or a hydrolase isolated therefrom
US5405972A (en) 1993-07-20 1995-04-11 Florida State University Synthetic process for the preparation of taxol and other tricyclic and tetracyclic taxanes
DE69431135T2 (de) 1993-11-15 2003-03-27 Mitsui Chemicals, Inc. Methode zur Herstellung von Taxan-Typ Diterpen und Methode zur Gewinnung von Kulturzellen die Taxan-Typ Diterpen in hohen Ausbeuten herstellen
US5508447A (en) 1994-05-24 1996-04-16 Board Of Regents, The University Of Texas System Short synthetic route to taxol and taxol derivatives
US5616330A (en) 1994-07-19 1997-04-01 Hemagen/Pfc Stable oil-in-water emulsions incorporating a taxine (taxol) and method of making same
US5679807A (en) 1995-01-30 1997-10-21 Hauser, Inc. Preparation of taxol and docetaxel through primary amines
US5675025A (en) 1995-06-07 1997-10-07 Napro Biotherapeutics, Inc. Paclitaxel synthesis from precursor compounds and methods of producing the same
US5780653A (en) 1995-06-07 1998-07-14 Vivorx Pharmaceuticals, Inc. Nitrophenyl, 10-deacetylated substituted taxol derivatives as dual functional cytotoxic/radiosensitizers
FR2736355B1 (fr) * 1995-07-07 1997-11-07 Pf Medicament Procede d'extraction et d'isolement de la 10-desacetylbaccatine iii
US5760251A (en) 1995-08-11 1998-06-02 Sepracor, Inc. Taxol process and compounds
US5654448A (en) 1995-10-02 1997-08-05 Xechem International, Inc. Isolation and purification of paclitaxel from organic matter containing paclitaxel, cephalomannine and other related taxanes
US5756536A (en) 1995-11-03 1998-05-26 Purdue Research Foundation Microbial transformation of taxol and cephalomannine
US5767297A (en) 1997-02-05 1998-06-16 Ensuiko Sugar Refining Co., Ltd. Taxoid derivative and method of producing thereof
US5795909A (en) 1996-05-22 1998-08-18 Neuromedica, Inc. DHA-pharmaceutical agent conjugates of taxanes
US5773629A (en) 1996-06-14 1998-06-30 Industrial Technology Research Institute Synthesis of (4S, 5R) -2, 4-diphenyl-5-carboxy-oxazoline derivative as taxol side-chain precursor
US5750737A (en) 1996-09-25 1998-05-12 Sisti; Nicholas J. Method for paclitaxel synthesis
US5739359A (en) 1997-01-24 1998-04-14 Virginia Tech Intellectual Properties, Inc. Methods for preparing 1-deoxy paclitaxels
US5969165A (en) 1999-01-07 1999-10-19 508037 (Nb) Inc. Isolation and purification of paclitaxel and other related taxanes by industrial preparative low pressure chromatography on a polymeric resin column
CA2299149C (fr) * 1999-06-22 2010-09-21 Chaichem Pharmaceuticals International Procede d'isolation et de purification du paclitaxel a partir de sources naturelles

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6452024B1 (en) * 2000-02-22 2002-09-17 Chaichem Pharmaceuticals International Process for extraction and purification of paclitaxel from natural sources

Also Published As

Publication number Publication date
JP4563994B2 (ja) 2010-10-20
DE602004011034D1 (de) 2008-02-14
CA2516811A1 (en) 2004-09-10
EP1608636A1 (en) 2005-12-28
WO2004076435A1 (en) 2004-09-10
CA2516811C (en) 2009-04-14
JP2006519184A (ja) 2006-08-24
EP1608636B1 (en) 2008-01-02
CN1774431A (zh) 2006-05-17
KR101114982B1 (ko) 2012-03-06
KR20050114627A (ko) 2005-12-06
DE602004011034T2 (de) 2009-02-12
US6759539B1 (en) 2004-07-06
HK1087109A1 (en) 2006-10-06
ATE382613T1 (de) 2008-01-15

Similar Documents

Publication Publication Date Title
KR100706983B1 (ko) 천연 원료로부터의 파크리택셀의 추출 및 정제 방법
CN1774431B (zh) 从天然原料中分离和提纯紫杉醇的方法
CN101560197B (zh) 从人工栽培的红豆杉枝叶中提取紫杉醇的方法
JP2006519184A5 (https=)
AU784323B2 (en) Production of taxol and taxanes
US3422090A (en) Process of producing esters from plants of the genus valeriana
US7169307B2 (en) Process for the extraction of paclitaxel and 9-dihydro-13-acetylbaccatin III from Taxus
CN1313460C (zh) 一种提取花青素的方法
KR100561111B1 (ko) Ｔａｘｕｓ 식물종의 회수가능한 부위로부터 10-데아세틸박카틴 Ⅲ의 분리방법
SU1146050A1 (ru) Способ получени @ -экдизона из растени рода @
US6878832B2 (en) Isolation of taxanes
HK1087109B (en) Process for isolation and purification of paclitaxel from natural sources
KR100624104B1 (ko) 파클리탁셀 함유물질로부터 파클리탁셀의 정제방법
EP1326870B1 (en) Extraction method
RU2067453C1 (ru) Способ получения сангвиритрина
CN105085443A (zh) 一种以曼地亚红豆杉枝叶为原料制备高纯度10-脱乙酰基巴卡亭ⅲ的方法
CN1442413A (zh) 用可再生资源提取药用紫杉醇及其衍生物的方法
CN110845449A (zh) 一种红豆杉提取紫杉醇的方法
CN1069641C (zh) 一种清洁纯化紫杉醇的方法
CN109541063B (zh) 从南山茶中提取山奈酚葡萄糖苷类化合物的方法
EP0707005A1 (fr) Procédé d'obtention d'oligomères procyanidoliques
CN107089994B (zh) 一种从胶霉菌素油膏中回收胶霉菌素的方法
CA2536000C (en) Process for the extraction of paclitaxel and 9-dihydro-13-acetylbaccatin iii from taxus
KR970061883A (ko) 택서스속 식물체로부터 택솔의 대량 추출 정제방법

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1087109

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
REG Reference to a national code

Ref country code: HK

Ref legal event code: GR

Ref document number: 1087109

Country of ref document: HK

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20110323

Termination date: 20140127