CN1772766A - 抗细胞凋亡相关乙酰胆碱酯酶单克隆抗体及其用途 - Google Patents

抗细胞凋亡相关乙酰胆碱酯酶单克隆抗体及其用途 Download PDF

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Publication number
CN1772766A
CN1772766A CNA2004100681470A CN200410068147A CN1772766A CN 1772766 A CN1772766 A CN 1772766A CN A2004100681470 A CNA2004100681470 A CN A2004100681470A CN 200410068147 A CN200410068147 A CN 200410068147A CN 1772766 A CN1772766 A CN 1772766A
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China
Prior art keywords
ache
monoclonal antibody
antibody
cell
apoptosis
Prior art date
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Pending
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CNA2004100681470A
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English (en)
Chinese (zh)
Inventor
张学军
吴军
姜华
向安春
张宝
吴伟荣
叶威源
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Shanghai Institutes for Biological Sciences SIBS of CAS
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Shanghai Institutes for Biological Sciences SIBS of CAS
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Priority to CNA2004100681470A priority Critical patent/CN1772766A/zh
Priority to PCT/CN2005/001888 priority patent/WO2006050667A1/fr
Publication of CN1772766A publication Critical patent/CN1772766A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2510/00—Detection of programmed cell death, i.e. apoptosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Urology & Nephrology (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Psychology (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CNA2004100681470A 2004-11-12 2004-11-12 抗细胞凋亡相关乙酰胆碱酯酶单克隆抗体及其用途 Pending CN1772766A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CNA2004100681470A CN1772766A (zh) 2004-11-12 2004-11-12 抗细胞凋亡相关乙酰胆碱酯酶单克隆抗体及其用途
PCT/CN2005/001888 WO2006050667A1 (fr) 2004-11-12 2005-11-10 ANTICORPS MONOCLONAUX DIRIGES CONTRE L’ACETYLCHOLINESTERASE LIEE A L’APOPTOSE (AR-AChE) ET LEUR USAGE

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNA2004100681470A CN1772766A (zh) 2004-11-12 2004-11-12 抗细胞凋亡相关乙酰胆碱酯酶单克隆抗体及其用途

Publications (1)

Publication Number Publication Date
CN1772766A true CN1772766A (zh) 2006-05-17

Family

ID=36336211

Family Applications (1)

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CNA2004100681470A Pending CN1772766A (zh) 2004-11-12 2004-11-12 抗细胞凋亡相关乙酰胆碱酯酶单克隆抗体及其用途

Country Status (2)

Country Link
CN (1) CN1772766A (fr)
WO (1) WO2006050667A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102921000A (zh) * 2011-08-08 2013-02-13 中国科学院上海生命科学研究院 乙酰胆碱酯酶作为核酸酶的应用
CN103087154A (zh) * 2012-12-05 2013-05-08 江苏澳格姆生物科技有限公司 一种用于制备检测乙酰胆碱酯酶的单克隆抗体的多肽及其应用

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
PT1976877E (pt) 2005-11-30 2014-04-29 Abbvie Inc Anticorpos monoclonais contra proteína beta-amilóide e suas utilizações
ES2524984T3 (es) 2005-11-30 2014-12-16 Abbvie Inc. Anticuerpos anti-globulómero a?, porciones de unión a antígeno de estos, hibridomas correspondientes, ácidos nucleicos, vectores, células huésped, métodos para producir dichos anticuerpos, composiciones que comprenden dichos anticuerpos, usos de dichos anticuerpos, y métodos para usar dichos anticuerpos
US8455626B2 (en) 2006-11-30 2013-06-04 Abbott Laboratories Aβ conformer selective anti-aβ globulomer monoclonal antibodies
US8895004B2 (en) 2007-02-27 2014-11-25 AbbVie Deutschland GmbH & Co. KG Method for the treatment of amyloidoses
MX336196B (es) 2010-04-15 2016-01-11 Abbvie Inc Proteinas de union a amiloide beta.
EP3533803B1 (fr) 2010-08-14 2021-10-27 AbbVie Inc. Anticorps anti-bêta-amyloïde

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8927389D0 (en) * 1989-12-04 1990-01-31 Jehanli Ahmed M T Monoclonal antibodies
GB9606040D0 (en) * 1996-03-22 1996-05-22 Isis Innovation Active peptide
CN1072722C (zh) * 1997-12-30 2001-10-10 中国科学院上海细胞生物学研究所 抗肿瘤药物的筛选方法
CN1059702C (zh) * 1997-12-30 2000-12-20 中国科学院上海细胞生物学研究所 从哺乳类细胞中获得脑型乙酰胆碱酯酶的方法
IL140071A0 (en) * 2000-12-04 2002-02-10 Yissum Res Dev Co Human antibodies to specific acetylcholinesterase variants and their use as diagnostic agents for cholinergic neurodeterioration processes
CN1244700C (zh) * 2001-03-23 2006-03-08 中国科学院上海细胞生物学研究所 一种人乙酰胆碱酯酶异构体蛋白（ar－ache）及基因编码序列

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102921000A (zh) * 2011-08-08 2013-02-13 中国科学院上海生命科学研究院 乙酰胆碱酯酶作为核酸酶的应用
CN102921000B (zh) * 2011-08-08 2015-02-18 中国科学院上海生命科学研究院 乙酰胆碱酯酶作为核酸酶的应用
CN103087154A (zh) * 2012-12-05 2013-05-08 江苏澳格姆生物科技有限公司 一种用于制备检测乙酰胆碱酯酶的单克隆抗体的多肽及其应用

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Open date: 20060517