CN1748738A - Chinese medicine cinnamon twig and poria dripping pill and its preparing method - Google Patents
Chinese medicine cinnamon twig and poria dripping pill and its preparing method Download PDFInfo
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- CN1748738A CN1748738A CN 200510060814 CN200510060814A CN1748738A CN 1748738 A CN1748738 A CN 1748738A CN 200510060814 CN200510060814 CN 200510060814 CN 200510060814 A CN200510060814 A CN 200510060814A CN 1748738 A CN1748738 A CN 1748738A
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- 235000017803 cinnamon Nutrition 0.000 title claims description 12
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- Medicines Containing Plant Substances (AREA)
Abstract
The Chinese medicine cinnamom twig-poria dripping pill is prepared with medicinal component comprising cinnamom twig, poria, tree peony bark, red peony root or white peony root in 10-60 wt% and matrix in 40-90 wt%. The preparation process includes the main steps of: heating the supplementary material at 60-105 deg c to melt and mixing with medicinal component, making dripping pill with the mixed medicine liquid at 70-100 deg c in a dripping pill machine, cooling the dripping pill in coolant, eliminating coolant and selecting dripping pill. The present invention has the features of fast acting, reasonable compounding ratio, no harmful residue and stable product quality.
Description
Technical field
The invention belongs to Chinese medicine preparation and technology of preparing thereof, be meant that specifically a kind of is the drop pill and preparation method thereof of feedstock production with the Chinese medicine extract.The trade name of this drop pill is " cinnamon twig and poria dripping pill ".
Background technology
The Ramulus Cinnamomi Poria pill prescription comes from " the following married woman's pregnant pulse disease of Medical Treasures of the Golden Chamber volume is also controlled " piece of writing, is made up of Cortex cinnamomi japonici (Ramulus Cinnamomi) branch, Poria, Semen Persicae, Radix Paeoniae.
Ramulus Cinnamomi is the dry twig of canella Cortex Cinnamomi Cinnamomum cassia Presl.Spring, Xia Erji gather, and remove defoliation, dry, or section are dried.Character: product are elongated cylindrical, multi-branched, long 30～75cm, butt diameter 0.3～1cm.The surface is brown to rufous, and leaf scar, branch trace, bud trace, hole skin point-like or the point-like ellipse of vertical crest line, fine wrinkle and goose pimples shape arranged.Matter is hard and crisp, frangibility.Slice thick 2～4mm, section skin zone rufous, the woody part yellow-white is to light yellowish brown, and marrow slightly is square.Special fragrance is arranged, sweet, little suffering of distinguishing the flavor of, skin zone's flavor is denseer.Nature and flavor with return through, hot, sweet, warm.GUIXIN, lung, urinary bladder channel.Function with cure mainly: diaphoresis expelling pathogenic factors from muscles, promoting the flow of QI-blood by warming the meridian, supporing yang activating QI, the flat gas that spins.Be used for anemofrigid cold, coldness and pain in the epigastrium, cold in blood amenorrhea, arthralgia, phlegm retention, edema, cardiopalmus.
Poria is the dry sclerotia of Polyporaceae fungus Poria Poria cocos (Schw.) Wolf.Multiparasitization is on tree limits such as pinaceae plant Pinus densiflora or Pinus massoniana Lamb.Wild or cultivation, main product in Yunnan, ground such as Hubei, Sichuan.Former phytomorph: sclerotium class sphere, ellipse or irregular, diameter 10-30 centimetre or bigger, often be born on the roots such as pinaster.Soft when fresh, do the back hardening.The cot that dark brown, many wrinkles are arranged, inner powder shape is white or rose pink.The sporophore umbrella shape.Meridian distribution of property and flavor: Poria sweet in the mouth, light, property is flat.GUIXIN, lung, spleen, kidney channel.Function cures mainly: have the promoting diuresis to eliminate damp pathogen effect and be used for the edema oliguria, the phlegm retention vertigo and palpitation.As WULING SAN.Spleen invigorating mind calming effect is used for insufficiency of the spleen lack of appetite, has loose bowels in the loose stool, irritability, palpitation with fear insomnia.
Semen Persicae is the seed of rosaceous plant peach or mountain peach.Effect: blood stasis removing and clots absorbing, moisturize laxation.Cure mainly: amenorrhea ， mass in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.Contain amygdalin (amygdalin), emulsin (emulsin), fatty wet goods.Property is put down, bitter in the mouth, sweet.
Radix Paeoniae is a kind of ranunculaceae plant, is called again from grass, and be perennial herb.Bloom annual 4～May, and color and luster is bright beautiful bright and colourful.Ancients comment flower: Paeonia suffruticosa the first, and Radix Paeoniae the second, the meaning Paeonia suffruticosa is the flower king, Radix Paeoniae is the flower phase.Because it blooms slower, so be called " hall spring " again.Yet Radix Paeoniae is called as the flower of women section, be not the U.S. that spends because of it, but because its root is good.The root of Radix Paeoniae still is called " Radix Paeoniae ", is famous Chinese crude drug.Medical works " herbal classic " lining before more than 1,000 years, the title record of existing Radix Paeoniae.The outstanding physician's TAO Hong-Jing of the Northern and Southern Dynasties begins it is divided into two kinds of the Radix Paeoniae Alba, Radix Paeoniae Rubra.Their differences are: Radix Paeoniae Rubra is wild product, is used as medicine to give birth to usefulness with former medicine, and its function is longer than the removing heat from blood removing blood stasis, the yin nourishing of enriching blood.The Radix Paeoniae of producing with Zhejiang especially wherein, performance optimal is called " Radix Paeoniae Alba ".Ancient prescription is the hundreds of of main medicine with the Radix Paeoniae Alba, as " guizhi decoction " Rong Wei with Radix Paeoniae and flesh table; " Radix Scutellariae Decoction " uses the Ying Qi in Radix Paeoniae and the abdomen; " zhigancao decoction " is with the Radix Paeoniae cloudy liquid of feeling pulse of enriching blood.
Cortex Moutan another name: Cortex Moutan, unpeeled CORTEX MOUTAN, wooden Radix Paeoniae, Luoyang flower.Rough bark for cohosh Paeonia suffruticosa Paeoniasuffruticosa Sndr..Chemical constituent: contain the former glycoside of Cortex Moutan (paeonolide), paeonol (paeonol), paeoniflorin (paeoniflorin), hydroxypaeoniflorin, benzoylpaeoniflorin and volatile oil.Nature and flavor are cold in nature, bitter in the mouth, suffering.Function cures mainly: clearing away heat and cooling blood, blood circulation promoting competent silt.Be used for maculae caused by violent heat pathogen, tell, be defeated in battle, have blood in stool, the hectic fever due to YIN-deficiency consumptive fever, the amenorrhea dysmenorrhea, carbuncle sore tumefacting virus falls and pounces on the pain of injury.
" the Medical Treasures of the Golden Chamber opinion is annotated ": " medicinal Ramulus Cinnamomi Poria pill person, Ramulus Cinnamomi, Radix Paeoniae, monoyin and monoyang, Poria, Cortex Moutan, a gas one blood is transferred its cold temperature, holds up its healthy energy.Semen Persicae with broken stagnant blood Xiao Disorder addiction, and do not dislike damaging fetus blood person, so-called ill then disease work as also.Suffering from must be because of cold at the beginning of the card, and osmanthus can activating QI and eliminate that this is cold; The one-tenth of Disorder must be held the damp and hot nest capsule that is under the arm, Poria eliminating dampness by diuresis gas, and red clearing away heat from blood, Radix Paeoniae is held back liver blood and holds up spleen, and the blood that enables to unite is so then support the ear that just promptly uncharms." Poria has promoting diuresis to eliminate damp pathogen as principal agent among the we, the spleen reinforcing mind calming effect.With the Ramulus Cinnamomi warming YANG to promote diuresis that is harmonious, the effect of the drink dehumidifying that disappears is strong especially.Still have only pill and capsule at present.
Summary of the invention
The object of the present invention is to provide a kind of extract dry extract with Chinese medicine Ramulus Cinnamomi, Poria, Cortex Moutan, Radix Paeoniae Rubra or the Radix Paeoniae Alba, Semen Persicae is the Chinese medicine cinnamon twig and poria dripping pill of raw material.
It is the preparation method of the Chinese medicine cinnamon twig and poria dripping pill of raw material with Chinese medicine Ramulus Cinnamomi, Poria, Cortex Moutan, Radix Paeoniae Rubra or the Radix Paeoniae Alba, Semen Persicae extract dry extract that another object of the present invention provides a kind of
The present invention is implemented by following scheme.
A kind of Chinese medicine cinnamon twig and poria dripping pill of the present invention, it adds that by the Chinese crude drug principal agent extract 10%～60% formed of 100 parts of Ramulus Cinnamomi, 100 parts in Poria, 100 parts of Cortex Moutans, Radix Paeoniae Rubra or 100 parts of the Radix Paeoniae Albas, 100 parts of compatibilities of Semen Persicae by weight substrate 40%～90% is made.
Above-mentioned substrate can be polyethylene glycols, poloxamer, glycerol, gelatin, tween 80.
Wherein polyethylene glycols can be any proportioning between polyethylene glycol 6000, Macrogol 4000, Macrogol 2000, polyethylene glycol 1500 and the PEG400.
The preparation method of the cinnamon twig and poria dripping pill of above-mentioned prescription, it mainly comprises following process steps:
(1) Poria 80% of getting recipe quantity is ground into fine powder; The Cortex Moutan vapor distillation is collected distillate, divides and gets volatile ingredient, and is standby;
(2) medicinal residues and Ramulus Cinnamomi, Semen Persicae, Radix Paeoniae Rubra or the Radix Paeoniae Alba and remaining Poria are with 90% alcohol reflux twice of 8 times of amounts, and each 1.5 hours, merge extractive liquid, reclaimed ethanol to there not being the alcohol flavor, is evaporated to the clear paste of 1.20～1.30 (60 ℃);
(3) medicinal residues add 8 times of water gagings decoction secondaries again, each 1.5 hours, filter merging filtrate, be evaporated to the clear paste of relative density 1.20～1.30 (60 ℃), merge with above-mentioned clear paste, with Poria fine powder mixing, drying, pulverize, cross 100 mesh sieves, add above-mentioned volatile ingredient, it is standby to make the principal agent extract;
(4) getting 60 ℃～105 ℃ of adjuvants is heated into fused mass and mixes with aforesaid principal agent extract;
(5) the melting mixing medicinal liquid is moved into drop pill machine control temperature and drip system at 70 ℃～100 ℃;
(6) medicine liquid droplet to temperature is to cool off in 5 ℃～30 ℃ methyl-silicone oil or vegetable oil or the liquid Paraffin coolant, removes coolant, selects ball promptly.
Chinese medicine cinnamon twig and poria dripping pill of the present invention on the basis of conventional method for preparing drop pills to the kind of drop pill adjuvant and principal agent and all temps in proportioning dosage and the preparation process through repeatedly experimentation is preferred, have reasonable mixture ratio, steady quality, carry, convenient drug administration, advantage that effectively stripping is fast, bioavailability is high; It is simple that the preparation method of drop pill then has technology, is easy to control, and yield and quality is stable, the characteristics of no hazard residue.
The specific embodiment
The present invention is further illustrated below in conjunction with embodiment, and following each embodiment only is used to illustrate the present invention, but to not restriction of the present invention.
Embodiment one
Take by weighing Ramulus Cinnamomi 500g, Poria 500g, Cortex Moutan 500g, Radix Paeoniae Rubra 500g, the Semen Persicae 500g of recipe quantity, the Poria 400g that gets wherein is ground into fine powder; Cortex Moutan is all used vapor distillation, collects distillate, divides and gets volatile ingredient, and is standby; Cortex Moutan medicinal residues and Ramulus Cinnamomi, Semen Persicae, Radix Paeoniae Rubra and remaining Poria are with 90% alcohol reflux twice of 8 times of amounts, and each 1.5 hours, merge extractive liquid, reclaimed ethanol to there not being the alcohol flavor, is evaporated to the clear paste of 1.20～1.30 (60 ℃); Medicinal residues add 8 times of water gagings again and decoct secondary, each 1.5 hours, filter merging filtrate, be evaporated to the clear paste of relative density 1.20～1.30 (60 ℃), merge with above-mentioned clear paste, with Poria fine powder mixing, drying, pulverize, cross 100 mesh sieves, add above-mentioned volatile ingredient, it is standby to make the principal agent extract; Getting adjuvant 750g again is heated at 85 ℃ and takes by weighing 500g in fused mass and the aforesaid principal agent extract and mix; The melting mixing medicinal liquid is moved into drop pill machine control temperature drip system at 80 ± 2 ℃; Medicine liquid droplet to temperature is to cool off in 15 ℃ the methyl-silicone oil vegetable oil coolant, removes coolant, selects ball promptly.
Embodiment two
Take by weighing Ramulus Cinnamomi 500g, Poria 500g, Cortex Moutan 500g, Radix Paeoniae Alba 500g, the Semen Persicae 500g of recipe quantity, the Poria 400g that gets wherein is ground into fine powder; Cortex Moutan is all used vapor distillation, collects distillate, divides and gets volatile ingredient, and is standby; Cortex Moutan medicinal residues and Ramulus Cinnamomi, Semen Persicae, the Radix Paeoniae Alba and remaining Poria are with 90% alcohol reflux twice of 8 times of amounts, and each 1.5 hours, merge extractive liquid, reclaimed ethanol to there not being the alcohol flavor, is evaporated to the clear paste of 1.20～1.30 (60 ℃); Medicinal residues add 8 times of water gagings again and decoct secondary, each 1.5 hours, filter merging filtrate, be evaporated to the clear paste of relative density 1.20～1.30 (60 ℃), merge with above-mentioned clear paste, with Poria fine powder mixing, drying, pulverize, cross 100 mesh sieves, add above-mentioned volatile ingredient, it is standby to make the principal agent extract; Getting adjuvant 1000g again is heated at 85 ℃ and takes by weighing 500g in fused mass and the aforesaid principal agent extract and mix; The melting mixing medicinal liquid is moved into drop pill machine control temperature drip system at 75 ± 2 ℃; Medicine liquid droplet to temperature is to cool off in 30 ℃ the liquid Paraffin coolant, removes coolant, selects ball promptly.
Embodiment three
Take by weighing Ramulus Cinnamomi 500g, Poria 500g, Cortex Moutan 500g, Radix Paeoniae Rubra 500g, the Semen Persicae 500g of recipe quantity, the Poria 400g that gets wherein is ground into fine powder; Cortex Moutan is all used vapor distillation, collects distillate, divides and gets volatile ingredient, and is standby; Cortex Moutan medicinal residues and Ramulus Cinnamomi, Semen Persicae, Radix Paeoniae Rubra and remaining Poria are with 90% alcohol reflux twice of 8 times of amounts, and each 1.5 hours, merge extractive liquid, reclaimed ethanol to there not being the alcohol flavor, is evaporated to the clear paste of 1.20～1.30 (60 ℃); Medicinal residues add 8 times of water gagings again and decoct secondary, each 1.5 hours, filter merging filtrate, be evaporated to the clear paste of relative density 1.20～1.30 (60 ℃), merge with above-mentioned clear paste, with Poria fine powder mixing, drying, pulverize, cross 100 mesh sieves, add above-mentioned volatile ingredient, it is standby to make the principal agent extract; Getting adjuvant 1500g again is heated at 85 ℃ and takes by weighing 500g in fused mass and the aforesaid principal agent extract and mix; The melting mixing medicinal liquid is moved into drop pill machine control temperature drip system at 90 ± 2 ℃; Medicine liquid droplet to temperature is to cool off in 5 ℃ the vegetable oil coolant, removes coolant, selects ball promptly.
Embodiment four
Take by weighing Ramulus Cinnamomi 500g, Poria 500g, Cortex Moutan 500g, Radix Paeoniae Alba 500g, the Semen Persicae 500g of recipe quantity, the Poria 400g that gets wherein is ground into fine powder; Cortex Moutan is all used vapor distillation, collects distillate, divides and gets volatile ingredient, and is standby; Cortex Moutan medicinal residues and Ramulus Cinnamomi, Semen Persicae, the Radix Paeoniae Alba and remaining Poria are with 90% alcohol reflux twice of 8 times of amounts, and each 1.5 hours, merge extractive liquid, reclaimed ethanol to there not being the alcohol flavor, is evaporated to the clear paste of 1.20～1.30 (60 ℃); Medicinal residues add 8 times of water gagings again and decoct secondary, each 1.5 hours, filter merging filtrate, be evaporated to the clear paste of relative density 1.20～1.30 (60 ℃), merge with above-mentioned clear paste, with Poria fine powder mixing, drying, pulverize, cross 100 mesh sieves, add above-mentioned volatile ingredient, it is standby to make the principal agent extract; Getting adjuvant 2000g again is heated at 85 ℃ and takes by weighing 500g in fused mass and the aforesaid principal agent extract and mix; The melting mixing medicinal liquid is moved into drop pill machine control temperature drip system at 90 ± 2 ℃; Medicine liquid droplet to temperature is to cool off in 10 ℃ the vegetable oil coolant, removes coolant, selects ball promptly.
Embodiment five
Claim Ramulus Cinnamomi 500g, Poria 500g, Cortex Moutan 500g, Radix Paeoniae Alba 500g, the Semen Persicae 500g of recipe quantity, the Poria 400g that gets wherein is ground into fine powder; Cortex Moutan is all used vapor distillation, collects distillate, divides and gets volatile ingredient, and is standby; Cortex Moutan medicinal residues and Ramulus Cinnamomi, Semen Persicae, the Radix Paeoniae Alba and remaining Poria are with 90% alcohol reflux twice of 8 times of amounts, and each 1.5 hours, merge extractive liquid, reclaimed ethanol to there not being the alcohol flavor, is evaporated to the clear paste of 1.20～1.30 (60 ℃); Medicinal residues add 8 times of water gagings again and decoct secondary, each 1.5 hours, filter merging filtrate, be evaporated to the clear paste of relative density 1.20～1.30 (60 ℃), merge with above-mentioned clear paste, with Poria fine powder mixing, drying, pulverize, cross 100 mesh sieves, add above-mentioned volatile ingredient, it is standby to make the principal agent extract; Getting adjuvant 335g again is heated at 85 ℃ and takes by weighing 500g in fused mass and the aforesaid principal agent extract and mix; The melting mixing medicinal liquid is moved into drop pill machine control temperature drip system at 75 ± 2 ℃; Medicine liquid droplet to temperature is to cool off in 30 ℃ the liquid Paraffin coolant, removes coolant, selects ball promptly.
Claims (4)
1. cinnamon twig and poria dripping pill, it is characterized in that: it is by the Chinese crude drug principal agent extract 10%～60% made of 100 parts of Ramulus Cinnamomi, 100 parts in Poria, 100 parts of Cortex Moutans, Radix Paeoniae Rubra or 100 parts of the Radix Paeoniae Albas, 100 parts of compatibilities of Semen Persicae by weight, adds that substrate 40%～90% is made.
2. described cinnamon twig and poria dripping pill according to claim 1 is characterized in that: described substrate is polyethylene glycols, poloxamer, glycerol, gelatin, tween 80.
3. cinnamon twig and poria dripping pill according to claim 2 is characterized in that: its polyethylene glycols is any proportioning between polyethylene glycol 6000, Macrogol 4000, Macrogol 2000, polyethylene glycol 1500 and the PEG400.
4. the preparation method of cinnamon twig and poria dripping pill according to claim 3 is characterized in that it comprises following process steps:
(1) Poria 80% of getting recipe quantity is ground into fine powder; The Cortex Moutan vapor distillation is collected distillate, divides and gets volatile ingredient, and is standby;
(2) medicinal residues and Ramulus Cinnamomi, Semen Persicae, Radix Paeoniae Rubra or the Radix Paeoniae Alba and remaining Poria are with 90% alcohol reflux twice of 8 times of amounts, and each 1.5 hours, merge extractive liquid, reclaimed ethanol to there not being the alcohol flavor, is evaporated to the clear paste of 1.20～1.30 (60 ℃);
(3) medicinal residues add 8 times of water gagings decoction secondaries again, each 1.5 hours, filter merging filtrate, be evaporated to the clear paste of relative density 1.20～1.30 (60 ℃), merge with above-mentioned clear paste, with Poria fine powder mixing, drying, pulverize, cross 100 mesh sieves, add above-mentioned volatile ingredient, it is standby to make the principal agent extract;
(4) getting 60 ℃～105 ℃ of adjuvants is heated into fused mass and mixes with aforesaid principal agent extract;
(5) the melting mixing medicinal liquid is moved into drop pill machine control temperature and drip system at 70 ℃～100 ℃;
(6) medicine liquid droplet to temperature is to cool off in 5 ℃～30 ℃ methyl-silicone oil or vegetable oil or the liquid Paraffin coolant, removes coolant, selects ball promptly.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510060814 CN1748738A (en) | 2005-09-17 | 2005-09-17 | Chinese medicine cinnamon twig and poria dripping pill and its preparing method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101491606B (en) * | 2008-12-31 | 2011-11-30 | 四川禾邦阳光制药股份有限公司 | Micro-pills of cassia twig and Tuckahoe and preparation method thereof |
| US10548940B2 (en) | 2014-05-12 | 2020-02-04 | Beijing Hebabiz Biotechnology Co., Inc. | Pharmaceutical composition for controlling blood lipids and body weight, and use thereof |
-
2005
- 2005-09-17 CN CN 200510060814 patent/CN1748738A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101491606B (en) * | 2008-12-31 | 2011-11-30 | 四川禾邦阳光制药股份有限公司 | Micro-pills of cassia twig and Tuckahoe and preparation method thereof |
| US10548940B2 (en) | 2014-05-12 | 2020-02-04 | Beijing Hebabiz Biotechnology Co., Inc. | Pharmaceutical composition for controlling blood lipids and body weight, and use thereof |
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