CN108686007A - A kind of Chinese medicine composition of reducing blood lipid - Google Patents

A kind of Chinese medicine composition of reducing blood lipid Download PDF

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Publication number
CN108686007A
CN108686007A CN201810988757.4A CN201810988757A CN108686007A CN 108686007 A CN108686007 A CN 108686007A CN 201810988757 A CN201810988757 A CN 201810988757A CN 108686007 A CN108686007 A CN 108686007A
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chinese medicine
medicine composition
blood lipid
reducing blood
active ingredient
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邓秋霞
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Shenzhen City Development Technology Co Ltd
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Shenzhen City Development Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/746Morinda
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233Bupleurum
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/46Eucommiaceae (Eucommia family), e.g. hardy rubber tree
    • AHUMAN NECESSITIES
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/60Moraceae (Mulberry family), e.g. breadfruit or fig
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/62Nymphaeaceae (Water-lily family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/64Orobanchaceae (Broom-rape family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708Rheum (rhubarb)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734Crataegus (hawthorn)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The present invention provides a kind of Chinese medicine composition of reducing blood lipid, which is made of active ingredient and the acceptable auxiliary material of medicine, and the active ingredient is made of the bulk pharmaceutical chemicals of following quality proportioning:10~30g of Morinda officinalis, 10~30g of Cortex Eucommiae, 20~40g of hawthorn, 20~40g of lotus nut, 25~35g of rheum officinale, 20~30g of Herba Cistanches, 15~25g of uncaria, 20~30g of radix bupleuri, 20~30g of antelope's horn, 20~30g of fructus cannabis, 30~40g of Eclipta prostrata, 20~30g of Radix Angelicae Sinensis, 20~30g of Herba Artemisiae Scopariae, 10~20g of radix paeoniae rubra.Chinese medicine composition made of the present invention, have effects that The flat liver of heat-clearing and resolving sputum promoting blood circulation, the symptoms such as head dizziness, weakness of limbs, insomnia forgetfulness caused by blood fat and treatment hyperlipidemia can be reduced, achieve the effect that reducing blood lipid faster, and without any toxicity and side effects, effect for reducing fat is steady, effect stability, and reparation technology is simple and easy to do.

Description

A kind of Chinese medicine composition of reducing blood lipid
[Technical field]
The present invention relates to field of Chinese herbal medicine technology, more particularly to a kind of Chinese medicine composition of reducing blood lipid.
[Background technology]
As a kind of common disease of the person, angiocardiopathy have become threaten mankind nowadays health big factors it One.In recent years, it with the aging of China human mortality and the improvement of people's living standards, lives, the quickening of work rhythm, diet It is accustomed to high thermalization, the development in high esterified direction, the hyperlipemic patients in crowd are in increasing trend.
Currently, being directed to reducing blood lipid problem, Western medicine class hypolipidemic is to use Statins for leading products, but these Western medicine While lipid-loweringing, it is non-adverse reactions, the side effects such as blood glucose rise, nausea, abdominal distension, diarrhea and hepatic disorder to be accompanied by Chang Mingxian.Chinese medicine class cardiovascular disease therapies preparation had been increasingly becoming the best selling variety on domestic market in recent years.With Western medicine system Agent is compared, and Chinese medicine composition has the characteristics that " multiple target point, manifold effect ", because theory of traditional Chinese medical science thinks, human body is an entirety, therefore Promoting blood circulation stasis of blood class Chinese medicine, which has, eliminates atherosclerotic plaque, the multi-effects such as dredging vascellum and acceleration blood circulation, therefore in It cures class cardiovascular disease preparation and has more advantage compared with acting on single Western medicine preparation.This shows the numerous patients in China to the Chinese medicine class heart The approval of blood vessel preparation clinical effectiveness, but Chinese medicine currently on the market treats that some are palliative, and some use price Expensive ingredient, many product lipid-lowering effect unobvious, effect is unstable after lipid-loweringing, it is easy to which rebound rises, the defective value It must improve.
[Invention content]
The purpose of the present invention is to provide a kind of Chinese medicine composition of reducing blood lipid, the Chinese medicine composition have The flat liver of heat-clearing and The effect of resolving sputum is invigorated blood circulation can reduce the diseases such as head dizziness, weakness of limbs and insomnia forgetfulness caused by blood fat and treatment hyperlipidemia Shape achievees the effect that reducing blood lipid, effect for reducing fat flattening effect are stablized faster.
Technical scheme is as follows:
The Chinese medicine composition of a kind of Chinese medicine composition of reducing blood lipid, the reducing blood lipid is acceptable with medicine by active ingredient Auxiliary material forms, and the active ingredient is made of the bulk pharmaceutical chemicals of following quality proportioning:
In order to obtain better effect, the active ingredient of the invention can also be preferably by the raw material of following quality proportioning Medicine is made:
In order to obtain better effect, the active ingredient of the invention can also be preferably by the raw material of following quality proportioning Medicine is made:
In order to obtain better effect, the active ingredient of the invention can also be preferably by the raw material of following quality proportioning Medicine is made:
In order to obtain better effect, the active ingredient of the invention can also be preferably by the raw material of following quality proportioning Medicine is made:
The Chinese medicine composition of reducing blood lipid of the present invention is oral agents, such as granule, capsule or tablet.
The Chinese medicine composition of reducing blood lipid of the present invention may be used various common preparation methods and obtain, one of which Easy-to-use preparation method includes the following steps:
1) bulk pharmaceutical chemicals, are weighed according to the ratio, are put it into marmite, the addition dipped 3~4cm of powder of clear water, and immersion 10~ 20min;
2), first the bulk pharmaceutical chemicals being immersed in marmite clear water are boiled with high heat, it is changed to be cooked by slow fire 25 later~ 35min, it is spare after leaching decocting liquid;
3) step 2), is filtered into remaining filter residue successively according to the operating method of step 1) and step 2), is carried out again Processing, filters to take decocting liquid, spare;
4), the decocting liquid that will be obtained in step 2) and step 3) mixes concentration, and stirs evenly, and it is molten to form Chinese medicine composition Liquid formulation.
Preferably, in the step 1), the dipped powder 4cm of clear water.
Preferably, in the step 1), soaking time 15min.
Preferably, in the step 2), it is 20min to be cooked by slow fire the time.
The theoretical foundation of the present invention is:
Morinda officinalis, sweet in flavor, pungent, slightly warm in nature returns kidney, Liver Channel, kidney-replenishing, strengthening the bones and muscles, wind-damp dispelling.The liver and the kidney have a common source, Morinda offcinalis How It is included into Liver Channel and removes liver heresy while kidney-replenishing.Morinda officinalis is madder wort Morinda officinalis Morinda ojj: The dry root of icinalis How, whole year can excavate, and cleaned after excavation and remove fibrous root, shone to 6 seventy percent gently, gently beaten Flat dry can be used.Morinda officinalis is born under mountain valley small stream side and mountainous region sparse woods, and the ground such as Fujian, Guangdong, Hainan and Guangxi are distributed in, With kidney-replenishing, the effect of strengthening the bones and muscles, wind-damp dispelling.It is usually used in impotence and seminal emission, uterus cold infertile, irregular menstruation, few abdomen crymodynia, rheumatism Numbness pain and muscles and bones impotence.
Cortex Eucommiae, nature and flavor are sweet, micro-pungent, it is warm-natured enter Liver Channel, kidney channel.Cure mainly spinal column ache, arthralgia pain due to rheumatism, fetal irritability, custom Property miscarriage etc..Cortex Eucommiae is the dry bark of Eucommiaceae plant Cortex Eucommiae, is the rare tonic herb of China.Using folium cortex eucommiae as Du of raw material Many effects such as secondary tea set filling liver kidney, strengthening the bones and muscles, lowering blood pressure and blood fat and tocolysis.Cortex Eucommiae is sweet in flavor and warm in property, there is tocolysis hypertension and hyperlipemia effect With having effects that lowering blood pressure and blood fat with compatibilities such as the fleece-flower root and Rhizoma Chuanxiongs, and to physically weak people's lowering blood pressure and blood fat without cold and cool disadvantage. Cortex Eucommiae and Morinda officinalis are the perfect matches in kidney-reinforcing drug.
Hawthorn is edible plants, and stone fruit, matter is hard, and pulp is thin, and taste is slightly sour puckery.Thornbuss is machaka, branch It is dense, there are spinelet, sprout to have pubescence.Sprig puce, old branch taupe.Hawthorn is the distinctive dual-purpose of drug and fruit seeds in China.Mountain Short, bristly hair or beard can be with disperse accumulation, the row stasis of blood, changes stagnant, the sour sweet slightly warm in nature of hawthorn, hawthorn energy prevention and cure of cardiovascular disease, have expansion blood vessel, cardiac stimulant, Increase coronary blood flow, improves heart vigor, stimulating central nervous system system, reduces blood pressure and cholesterol, softening blood vessel and diuresis And sedation;Prevent artery sclerosis, anti-aging, anticancer effect.Crataegolic acid also has cardiac effect, to senile heart disease It is helpful.
Lotus nut, it is bitter in taste, it trembles with fear, it is nontoxic, enter the heart, lung and kidney three and pass through, there is antihypertensive effect and certain cardiac effect.Lotus seeds Its taste of the heart is poor, but has the benefits of fabulous decompression degreasing.It is the green plumule of the mature seed of nymphaeaceae plant lotus, master Originate in Hunan, Hubei, Jiangxi, Fujian, Jiangsu and zhejiang and other places.Its taste bitter and cold, have clear away heart-fire, reduce phlegm and internal heat, stopping blooding and it is puckery essence Effect.Vexed, thirsty, haematemesis and seminal emission are cured mainly, it can gentle QI of five ZANG-organs.
Rheum officinale is the root and rhizome of polygonum rheum palmatum or Rheum tanguticum Maxim.It excavates in the fall, cleans, dry, cut Piece.Effect is mainly under rushing down, attacks product, heat-clearing and cool blood.Modern research shows that rheum officinale also has preferable effect for reducing blood fat, can steep Tea-drinking, but since it has apparent catharsis effect, the weakness of the spleen and the stomach person to use with caution, can not be used for a long time.It, can if being that the elderly uses Rheum officinale is slightly steamed and is then used, can preferably alleviate its pretty strong property in this way.But rheum officinale is associated with other Chinese medicines of the invention, lead to diarrhea Effect weakens significantly, does not influence lipid-lowering effect.
Herba Cistanches are sweet in flavor, salty;It is warm-natured, return kidney, large intestine channel, there is the effect of kidney-replenishing, benefiting essence-blood, ease constipation road, cure mainly kidney The deficiency of yang declines, and the impotence of asthenia of essence and blood, seminal emission, gonorrhoea, the frequent micturition heeltap, pain in the back flaccidity of lower limbs, tinnitus mesh flower, menstruation are spread out phase, fertility With the illnesss such as dry constipation of intestines.Herba Cistanches (scientific name:Cistanche deserticola Ma), alias boundary rue, desert cistanche, is looked into very little rue It is dry to accuse sub- (Mongolian), belong to endangered species.It belongs to tall and big draft, 40~160 centimetres high, mostly lower life.5~June of florescence, fruit 6~August of phase.Main product is also distributed in Xinjiang and Alashan Area, inner Mongolia Autonomous Region alliance in Gansu and Ningxia.
Uncaria, effects sweet in flavor cold in nature are The flat liver of heat-clearing, and antispastic relieves dizziness, high fever, infantile convulsions, epilepsy, etc..Because it contains rhynchophyllin and isorhynchophylline, therefore there is excitement Respiratory center expands peripheral vessels, has the function of reducing blood pressure.But it boils more than 20 minutes, decompression composition is partly broken It is bad, thus boil medicine preferably after under.Uncaria alias is called hook fourth and ramulus uncariae rhynchophyllae, for madder wort uncaria or Uncaria sinensis and its belongs to more The buckle branch of kind of plant, climbs up by holding on to shape shrub, and uncaria is sweet in flavor, cold nature, and can be stopped working heat-clearing with soothing the liver, can with liver-yang hyperactivity institute The diseases such as the logical, hot eyes of the dizziness of cause, head, containing there are many indoles alkaloids, including rhynchophyllin, isorhynchophylline, hook in uncaria stem branch Rattan total alkali and non-alkaloid.Main effectively antihypertensive compositions are rhynchophyllin and isorhynchophylline in uncaria, and the hypertension and hyperlipemia of the latter is imitated Fruit is better than rhynchophyllin.
Radix bupleuri:Meridian distribution of property and flavor, it is bitter, it is slightly cold.Return liver, gallbladder channel.With in inducing diaphoresis, the effect of dispersing stagnated hepatoqi and rising Yang.With In cold, fever, fevers and chills alternate, distending pain in the chest and hypochondrium, irregular menstruation, sub-official prolapses, rectal prolapse.1, for fevers and chills alternate, cold, fever etc. Disease.Treatment is evil in few sun, fevers and chills alternate, is often equal with radix scutellariae, the tuber of pinellia and uses;Cure cold fever, with pueraria lobata, gypsum, radix scutellariae compatibility. 2, for stagnation of liver qi, pain over the hypochondriac region, irregular menstruation etc..It is used together with medicines such as Radix Angelicae Sinensis, Radix Paeoniae Alba, rhizoma cyperi, Radix Curcumaes.3, under the deficiency of vital energy The diseases such as sunken, rush down prolapse of the anus for a long time, metroptosis.With Radix Codonopsis, Radix Astragali, cimicifugae foetidae etc..
Antelope's horn, for the angle of male bovid sahilite.Sahilite is put into"World Conservation Union" (IUCN) endangered species Red List ver3.1 in 2012 --- pole is endangered (CR), is forbidden to hunt, is distributed in the Xinjiang northwestward Border area.Antelope's horn taste taste is salty, cold in nature, Return liver, the heart channel of Hang-Shaoyin.Antelope's horn has suppressing hyperactive liver for calming endogenous wind, clears liver and improve vision, and dissipates the work(of blood removing toxic substances Effect.It is usually used in liver wind agitation, twitch, pre-eclampsia, high fever convulsion faints, and epilepsy is gone mad, dizziness of having a headache, cataract, epidemic heat syndrome The illnesss such as macular eruption and carbuncle sore tumefacting virus.
Fructus cannabis, sweet in flavor, mild-natured, returns spleen, stomach, large intestine channel, effect relax bowel, moisturize desinsection, and clinic name has fiery fiber crops Renhe stir-baked FRUCTUS CANNABIS.Fructus cannabis, the dry mature seed of moraceae plants hemp Cannabis sativa L., be distributed in northeast, The ground such as North China, East China, Central-South.It has the effect of relaxing bowel, and is usually used in blood deficiency and depleted fluid, dry constipation of intestines.Its fruit is in oval Shape, long 4~5.5mm, 2.5~4mm of diameter.Surface celadon or lark have fine white or brown reticulate pattern, both sides to have Rib, top is slightly sharp, and base portion has 1 round carpopodium trace.Pericarp is thin and crisp, broken.Kind skin green, cotyledon 2, milky are High oleic. Gas is micro-, lightly seasoned.
Eclipta prostrata, alias eclipta ("Tang materia medica"Described in), it is to enter the kidney channel of foot-Shaoyin and the liver channel of foot-Jueyin simply Tonic.Eclipta prostrata is cold in nature, sweet in flavor, and acid enters the kidney channel of foot-Shaoyin, the liver channel of foot-Jueyin,"Beautiful Chinese catalpa medicine solution"In it is on the books:Eclipta prostrata The black such as ink of juice, obtains few yin edema color, enters liver and grow blood, dark hair crow palpus.All can be stopped to lose blood, apply various sores.Juice applies eyebrow hair, life speed It is numerous.In modern Application, the main effect of Eclipta prostrata is nourishing YIN for benefiting the kidney, cooling blood and hemostasis, for kidney deficiency, YinXuXueRe and cause Bleeding patients are applicable in.
Radix Angelicae Sinensis, nature and flavor are sweet, pungent, bitter, temperature.Enter liver, the heart, the spleen channel.There are blood-nourishing and blood, tonifying blood and regulating menstruation, promoting blood circulation and stopping pain and ease constipation The effect of defaecation.Radix Angelicae Sinensis is sweet mend it is pungent dissipate, it is logical that hardship lets out temperature, can enrich blood and invigorate blood circulation, and and promoting qi circulation and relieving pain, cure mainly all mass formed by blood stasis, For the product of wanting of blood disease, particularly gynaecology's good medicine.All menoxenias, Amenorrhea, dysmenorrhoea and tire produce all diseases, no matter the deficiency of blood or blood It is stagnant, it can all apply.Surgery, can be with detumescence and apocenosis with ulcer sores are controlled;Traumatology is used for traumatic injury, can be with promoting blood circulation and stopping pain.Due to The pungent perfume (or spice) of Radix Angelicae Sinensis is walked to alter, and has the title of " gas medicine in blood ", therefore, clinical to coordinate with qi-regulating drug, can treat the card of qi and blood stagnation;With dispel Expelling wind drug coordinates, and can treat arthralgia pain due to rheumatism;Dry constipation of intestines are treated, are the work(for taking its ease constipation of enriching blood.In short, all category deficiency of blood stasis institute All caused illnesss can be used, and have cold person most appropriate with blood system.
The effect of Herba Artemisiae Scopariae, bitter, pungent, cold nature, returns spleen, stomach, liver, gallbladder channel, oriental wormwood clearing heat and promoting diuresis, cure mainly jaundice, urine Unfavorable, itchy sore and infectious jaundice type hepatitis etc..Pharmaceutical research shows that Herba Artemisiae Scopariae has cholagogic, liver function protecting, solution The effects that heat, anti-inflammatory, reducing blood lipid, decompression and coronary dilatation.Herba Artemisiae Scopariae alias wild marjoram, mouse pawl, Tian Naili, because dirt, Ma Xian, capillary wormwood, Suede wormwood artemisia, spire sweet wormwood or An Lvcao, Latin literary fame ArtemisiacapillarisThunb.Herba Artemisiae Scopariae is tubular flower mesh, composite family, ox It is not dead through the winter to platymiscium wormwood artemisia, old of Chun Zeyin and give birth to, it is therefore named because of old or oriental wormwood.Then become wormwood artemisia to its seedling of summer, therefore also known as oriental wormwood Wormwood artemisia.Folks of china is existing still have with rice flour make oriental wormwood cake, group custom.Oriental wormwood is cooked, and tender seedling is adopted, and always medicinal is Artemisia capillaris. Therefore there is the saying in " February oriental wormwood, May wormwood artemisia ".Herba Artemisiae Scopariae is distributed in the low altitude area of the countries such as China, Japan, Korea and Mongolia Riverbank and low hillside area.Oriental wormwood is there are two picking time, and the habit that spring adopts claims " capillary wormwood ", and the habit that autumn adopts claims " oriental wormwood Wormwood artemisia ".
Radix paeoniae rubra is the dry root of ranunculaceae plant radix paeoniae rubra or river radix paeoniae rubra, and bitter is cool in nature, have stagnation resolvation, analgesic, cool blood, , there is preferable treatment in the effect of detumescence to illnesss such as discharging fresh blood stool, irregular menstruation, spontaneous sweating, red eye, swell pain, abdominal pain, hypochondriac pains Effect.Pharmacology analysis shows that Chinese herbaceous peony contains Paeoniflorin, benzoic acid, volatile oil, resin, carbohydrate and starch etc., to dysentery bar Bacterium, staphylococcus have inhibiting effect, and have analgesia, calmness and anticonvulsant effect.
Chinese medicine thinks that the disease of human body should integrally be treated, and cannot treat the head when the head aches foot pain doctor's foot, it should on dialectical basis On treated.High fat of blood is seen on surface, is excessively high caused because of blood sugar for human body, but Chinese medicine improves the disease of sufferer, The specific tangible internal organs problem for having shape is not only considered, it is also contemplated that invisible feelings will problem.Chinese medicine thinks that hyperlipidemia is because of feelings will Internal injury, eating and drinking without temperance and overstrain damage, or body declines with age, damage of kidney-essence etc. leads to internal organs imbalance between YIN and YANG, is given birth in wind fire, Phlegm, which becomes silted up, hands over resistance, and qi and blood is against caused by unrest.Western medicine also treats hyperlipidemia, and doctor trained in Western medicine is usually promising to be reached target blood fat and frequently add and subtract dose Situations such as, therefore, also usually there is the larger phenomenon of blood fat bounce amplitudes.And Chinese medicine effect for reducing fat mitigates, and stablizes blood fat effect Preferably, present invention is particularly suitable for early stage, person in middle and old age's hyperlipemic patients and heavier high fat of blood to coordinate Chinese medicine of the invention Treatment, prevented also from blood fat compared with big bounce.
The present invention improves the therapeutic effect of sufferer hyperlipidemia, can be observed by following clinical patients and further be demonstrate,proved It is real.
1), observing time:In the case where technical solution of the present invention does not disclose, in April, 2017 in April, 2018 is selected One-year age.
2) object, is observed:In Shenzhen City, Guangdong Province, institute of traditional Chinese medicine selects 20 cases:Man 10, female 10;Age:45— 55 years old 10,55-75 years old 10;Occupation:Private enterprise master 10, the retired 10.The state of an illness:Total cholesterol (TC) exists 5.2mmol/L or more, triglycerides (TG) in 1.7mmol/L or more, low-density lipoprotein (LDL-C) 3.12mmol/L with On, high-density lipoprotein (HDL-C) in 1.04mmol/L hereinafter, even have head dizziness, visually unclear, weakness of limbs symptom.
3), application method:By oral solution made of the Chinese medicine composition of the reducing blood lipid of the embodiment of the present invention at postprandial 1 hour It takes, 3 times a day, each 300ml, with 1 month for 1 course for the treatment of, two courses for the treatment of are as observation of curative effect.
4), observing effect:
Continuously after taking two courses for the treatment of, wherein 9 patients are down to total cholesterol (TC) in 4.9mmol/L or so, glycerine Three esters (TG) are in 1.7mmol/L or so, and low-density lipoprotein (LDL-C) is in 3.12mmol/L hereinafter, high-density lipoprotein (HDL- C) in 1.04mmol/L or more, 8 patients are down to total cholesterol (TC) in 4.6mmol/L or so, and triglycerides (TG) exists 1.5mmol/L or so, low-density lipoprotein (LDL-C) is in 3.00mmol/L hereinafter, high-density lipoprotein (HDL-C) exists 1.10mmol/L or more is observed after being discontinued 7 days, and obviously do not rebound sign, and blood fat is steady, and head dizziness disappears, visually unclear, Weakness of limbs situation substantially improves.
Clinical trial 2:
1), observing time:In the case where technical solution of the present invention does not disclose, in June, 2017 in June, 2018 is selected One-year age.
2) object, is observed:In Shenzhen City, Guangdong Province Futian District, institute of traditional Chinese medicine selects 20 cases:Man 12, female 8;Age: 55-65 years old 10,65-75 years old 10;Occupation:Once the endomorphy type civil servant 10 of post leader was served as, endomorphy type commonly moves back Not civil servant 10.The state of an illness:For total cholesterol (TC) in 5.2mmol/L or more, triglycerides (TG) is low in 1.7mmol/L or more Density lipoprotein (LDL-C) is in 3.12mmol/L or more, and high-density lipoprotein (HDL-C) is in 1.04mmol/L hereinafter, even have head Portion's dizziness, visually unclear, weakness of limbs symptom.
3), application method:Invention formulation oral solution was taken at postprandial 1 hour, 3 times a day, each 300ml, with 1 The moon is 1 course for the treatment of, and two courses for the treatment of are as observation of curative effect.
4), observing effect:
Continuously after taking two courses for the treatment of, wherein 8 patients are down to total cholesterol (TC) in 4.9mmol/L or so, glycerine Three esters (TG) are in 1.7mmol/L or so, and low-density lipoprotein (LDL-C) is in 3.12mmol/L hereinafter, high-density lipoprotein (HDL- C) in 1.04mmol/L or more, 10 patients are down to total cholesterol (TC) in 4.6mmol/L or so, and triglycerides (TG) exists 1.5mmol/L or so, low-density lipoprotein (LDL-C) is in 3.00mmol/L hereinafter, high-density lipoprotein (HDL-C) exists 1.10mmol/L or more is observed after being discontinued 7 days, and obviously do not rebound sign, and blood fat is steady, and head dizziness disappears, visually unclear, Weakness of limbs situation substantially improves.
Conclusion:The Chinese medicine composition of the reducing blood lipid of the embodiment of the present invention can be substantially reduced the hyperglycemia of sufferer, no secondary work With.
The Chinese medicine composition of the reducing blood lipid of the present invention has effects that The flat liver of heat-clearing and resolving sputum promoting blood circulation, can reduce blood fat With the symptoms such as head dizziness, weakness of limbs, insomnia forgetfulness caused by treatment hyperlipidemia, achieve the effect that reducing blood lipid faster, and And without any toxicity and side effects, effect for reducing fat is steady, effect stability, and reparation technology is simple and easy to do.
During clinical observation, does not find that drug of the present invention has any undesirable toxic side effect, show in the present invention Drug composition is safe and effective.
[Specific implementation mode]
With reference to embodiment, the present invention will be described in detail.
Embodiment one
A kind of Chinese medicine composition of reducing blood lipid of the present embodiment is made of active ingredient and the acceptable auxiliary material of medicine, Described in active ingredient be made of the bulk pharmaceutical chemicals of following quality proportioning:
A kind of Chinese medicine composition of above-mentioned reducing blood lipid, active ingredient are prepared by following methods:
1) bulk pharmaceutical chemicals, are weighed according to the ratio, are put it into marmite, the dipped powder 4cm of clear water are added, and impregnate 15min;
2), first the bulk pharmaceutical chemicals being immersed in marmite clear water are boiled with high heat, are changed to be cooked by slow fire 20min later, It is spare after leaching decocting liquid;
3) step 2), is filtered into remaining filter residue successively according to the operating method of step 1) and step 2), is carried out again Processing, filters to take decocting liquid, spare;
4), the decocting liquid that will be obtained in step 2) and step 3) mixes concentration, and stirs evenly, and it is molten to form Chinese medicine composition Liquid formulation.
Above-mentioned Chinese medicine composition can also be made for granule, capsule or tablet.
The Chinese medicine composition of the reducing blood lipid of the present embodiment has effects that The flat liver of heat-clearing and resolving sputum promoting blood circulation, can reduce blood fat With the symptoms such as head dizziness, weakness of limbs, insomnia forgetfulness caused by treatment hyperlipidemia, achieve the effect that reducing blood lipid faster, and And without any toxicity and side effects, effect for reducing fat is steady, effect stability, and reparation technology is simple and easy to do.
Embodiment two
A kind of Chinese medicine composition of reducing blood lipid of the present embodiment is made of active ingredient and the acceptable auxiliary material of medicine, Described in active ingredient be made of the bulk pharmaceutical chemicals of following quality proportioning:
A kind of above-mentioned stilbene art Chinese medicine composition for treating Qi deficiency blood stasis type hepatocellular carcinoma, the preparation method of active ingredient It is identical as the preparation method of embodiment one.
Above-mentioned Chinese medicine composition can also be made for granule, capsule or tablet.
The Chinese medicine composition of the reducing blood lipid of the present embodiment has effects that The flat liver of heat-clearing and resolving sputum promoting blood circulation, can reduce blood fat With the symptoms such as head dizziness, weakness of limbs, insomnia forgetfulness caused by treatment hyperlipidemia, achieve the effect that reducing blood lipid faster, and And without any toxicity and side effects, effect for reducing fat is steady, effect stability, and reparation technology is simple and easy to do.
Embodiment three
The Chinese medicine composition of the reducing blood lipid of the present embodiment is made of, wherein institute active ingredient and the acceptable auxiliary material of medicine Active ingredient is stated to be made of the bulk pharmaceutical chemicals of following quality proportioning:
A kind of Chinese medicine composition of above-mentioned reducing blood lipid, the preparation method of the preparation method and embodiment one of active ingredient It is identical.
The Chinese medicine composition of above-mentioned reducing blood lipid can also be made for granule, capsule or tablet.
The Chinese medicine composition of the reducing blood lipid of the present embodiment has effects that The flat liver of heat-clearing and resolving sputum promoting blood circulation, can reduce blood fat With the symptoms such as head dizziness, weakness of limbs, insomnia forgetfulness caused by treatment hyperlipidemia, achieve the effect that reducing blood lipid faster, and And without any toxicity and side effects, effect for reducing fat is steady, effect stability, and reparation technology is simple and easy to do.
Example IV
A kind of Chinese medicine composition of reducing blood lipid of the present embodiment is made of active ingredient and the acceptable auxiliary material of medicine, Described in active ingredient be made of the bulk pharmaceutical chemicals of following quality proportioning:
A kind of Chinese medicine composition of above-mentioned reducing blood lipid, the preparation method of the preparation method and embodiment one of active ingredient It is identical.
Above-mentioned Chinese medicine composition can also be made for granule, capsule or tablet.
The Chinese medicine composition of the reducing blood lipid of the present embodiment has effects that The flat liver of heat-clearing and resolving sputum promoting blood circulation, can reduce blood fat With the symptoms such as head dizziness, weakness of limbs, insomnia forgetfulness caused by treatment hyperlipidemia, achieve the effect that reducing blood lipid faster, and And without any toxicity and side effects, effect for reducing fat is steady, effect stability, and reparation technology is simple and easy to do.
Embodiment five
A kind of Chinese medicine composition of reducing blood lipid of the present embodiment is made of active ingredient and the acceptable auxiliary material of medicine, Described in active ingredient be made of the bulk pharmaceutical chemicals of following quality proportioning:
A kind of Chinese medicine composition of above-mentioned reducing blood lipid, the preparation method of the preparation method and embodiment one of active ingredient It is identical.
Above-mentioned Chinese medicine composition can also be made for granule, capsule or tablet.
The Chinese medicine composition of the reducing blood lipid of the present embodiment has effects that The flat liver of heat-clearing and resolving sputum promoting blood circulation, can reduce blood fat With the symptoms such as head dizziness, weakness of limbs, insomnia forgetfulness caused by treatment hyperlipidemia, achieve the effect that reducing blood lipid faster, and And without any toxicity and side effects, effect for reducing fat is steady, effect stability, and reparation technology is simple and easy to do.
In conclusion the preferred embodiment of the present invention is as above, but above preferred embodiment is not to limit the present invention, originally The those of ordinary skill in field, without departing from the spirit and scope of the present invention, can make it is various change and retouch, such as will respectively match The effect of side is increased in the ratio in technical solution or reduction dose, this Chinese medicine composition obtained is simultaneously unaffected, therefore Protection scope of the present invention is subject to the range that claim defines.

Claims (10)

1. a kind of Chinese medicine composition of reducing blood lipid, the Chinese medicine composition is made of active ingredient and the acceptable auxiliary material of medicine, It is characterized in that, the active ingredient is made of the bulk pharmaceutical chemicals of following quality proportioning:
2. the Chinese medicine composition of reducing blood lipid according to claim 1, which is characterized in that the active ingredient is by following quality The bulk pharmaceutical chemicals of proportioning are made:
3. the Chinese medicine composition of reducing blood lipid according to claim 1, which is characterized in that the active ingredient is by following quality The bulk pharmaceutical chemicals of proportioning are made:
4. the Chinese medicine composition of reducing blood lipid according to claim 1, which is characterized in that the active ingredient is by following quality The bulk pharmaceutical chemicals of proportioning are made:
5. the Chinese medicine composition of reducing blood lipid according to claim 1, which is characterized in that the active ingredient is by following quality The bulk pharmaceutical chemicals of proportioning are made:
6. the Chinese medicine composition of reducing blood lipid according to claim 1, which is characterized in that the Chinese medicine composition of the reducing blood lipid For granule, capsule or tablet.
7. according to the Chinese medicine composition of Claims 1 to 5 any one of them reducing blood lipid, which is characterized in that the reducing blood lipid Chinese medicine composition is made by following methods:
1) bulk pharmaceutical chemicals, are weighed according to the ratio, are put it into marmite, the addition dipped 3~4cm of powder of clear water, and immersion 10~ 20min;
2), first the bulk pharmaceutical chemicals being immersed in marmite clear water are boiled with high heat, are changed to be cooked by slow fire 25~35min later, It is spare after leaching decocting liquid;
3) step 2), is filtered into remaining filter residue successively according to the operating method of step 1) and step 2), is handled again, Decocting liquid is filtered to take, it is spare;
4), the decocting liquid that will be obtained in step 2) and step 3) mixes concentration, and stirs evenly, and forms Chinese medicine composition solution system Agent.
8. the Chinese medicine composition of reducing blood lipid according to claim 7, which is characterized in that in the step 1), clear water leaching Cross powder 4cm.
9. the Chinese medicine composition of reducing blood lipid according to claim 7, which is characterized in that in the step 1), when immersion Between be 15min.
10. the Chinese medicine composition of reducing blood lipid according to claim 7, which is characterized in that in the step 2), be cooked by slow fire It is 20min to boil the time.
CN201810988757.4A 2018-08-28 2018-08-28 A kind of Chinese medicine composition of reducing blood lipid Pending CN108686007A (en)

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