CN1724682A - Cordyceps polypeptide product and its preparation method and application - Google Patents
Cordyceps polypeptide product and its preparation method and application Download PDFInfo
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- CN1724682A CN1724682A CNA2005100409616A CN200510040961A CN1724682A CN 1724682 A CN1724682 A CN 1724682A CN A2005100409616 A CNA2005100409616 A CN A2005100409616A CN 200510040961 A CN200510040961 A CN 200510040961A CN 1724682 A CN1724682 A CN 1724682A
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- caterpillar fungus
- chinese caterpillar
- silkworm chrysalis
- egg
- degreasing
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- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 27
- 229920001184 polypeptide Polymers 0.000 title claims abstract description 26
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 26
- 241000190633 Cordyceps Species 0.000 title claims description 15
- 238000002360 preparation method Methods 0.000 title claims description 9
- 241000255789 Bombyx mori Species 0.000 claims abstract description 41
- 241000233866 Fungi Species 0.000 claims abstract description 40
- 240000001307 Myosotis scorpioides Species 0.000 claims abstract description 39
- 238000005238 degreasing Methods 0.000 claims abstract description 31
- 238000000034 method Methods 0.000 claims abstract description 9
- KQLDDLUWUFBQHP-UHFFFAOYSA-N Cordycepin Natural products C1=NC=2C(N)=NC=NC=2N1C1OCC(CO)C1O KQLDDLUWUFBQHP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 150000001413 amino acids Chemical class 0.000 claims abstract description 7
- OFEZSBMBBKLLBJ-BAJZRUMYSA-N cordycepin Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)C[C@H]1O OFEZSBMBBKLLBJ-BAJZRUMYSA-N 0.000 claims abstract description 7
- OFEZSBMBBKLLBJ-UHFFFAOYSA-N cordycepine Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(CO)CC1O OFEZSBMBBKLLBJ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 230000008569 process Effects 0.000 claims abstract description 7
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 102000004190 Enzymes Human genes 0.000 claims abstract description 6
- 108090000790 Enzymes Proteins 0.000 claims abstract description 6
- 239000003814 drug Substances 0.000 claims abstract description 4
- 241001248610 Ophiocordyceps sinensis Species 0.000 claims description 31
- 239000000843 powder Substances 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 241001264174 Cordyceps militaris Species 0.000 claims description 16
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims description 12
- 230000007062 hydrolysis Effects 0.000 claims description 11
- 238000006460 hydrolysis reaction Methods 0.000 claims description 11
- 238000005119 centrifugation Methods 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 7
- 108090000145 Bacillolysin Proteins 0.000 claims description 6
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims description 6
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 6
- 102000035092 Neutral proteases Human genes 0.000 claims description 6
- 108091005507 Neutral proteases Proteins 0.000 claims description 6
- 229960005305 adenosine Drugs 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 6
- 239000007858 starting material Substances 0.000 claims description 6
- 238000009835 boiling Methods 0.000 claims description 5
- 235000013305 food Nutrition 0.000 claims description 5
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- 238000010298 pulverizing process Methods 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 2
- 239000007787 solid Substances 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 6
- 239000000463 material Substances 0.000 abstract description 5
- 102000004169 proteins and genes Human genes 0.000 abstract description 4
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- 241000382353 Pupa Species 0.000 abstract 3
- 239000004480 active ingredient Substances 0.000 abstract 1
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- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 235000013601 eggs Nutrition 0.000 description 35
- 230000000694 effects Effects 0.000 description 6
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- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
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- 206010011224 Cough Diseases 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 108090000526 Papain Proteins 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 102000035195 Peptidases Human genes 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
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- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to a Chinese caterpillar fungus polypeptide product that uses silkworm pupa or egg as culture medium, accesses pupa Chinese caterpillar fungus as raw material to gain after degreasing and enzyme hydrolyzing. The invention combines pupa Chinese caterpillar fungus with high protein material. Thus, it contains active ingredients like polypeptide, amino acid, cordycepin, etc. The invention has great edible value and medical value. It has advantages of simple manufacturing technology, short producing cycle, low process cost and it could be used in medicine, edible, and so on.
Description
Technical field
The present invention relates to a kind of cordyceps polypeptide product and its production and application.
Background technology
Cordyceps militaris (L.) Link. is a rare Chinese herbal medicine, also is called Cordyceps militaris (L.) Link. or Cordyceps militaris.Because of containing multiple biologically active substance such as cordycepin, cordycepic acid, adenosine, Cordyceps polysaccharide, SOD and effective constituents such as amino acid, various trace elements and VITAMIN, have calm, relieving cough and reducing sputum and suppress growth of tumour cell, increase body fitness and disease prevention is had the effect of peculiar immunity, be and genseng, pilose antler three big treasures equally celebrated for their achievements.
Polypeptide is proteinic rudimentary form, almost relates to the whole process of life such as human hormone, nerve, growth, reproduction, have regulate body function, the active active substance earns a bare living.
Along with science and technology development, popular health care consciousness generally improves, and the goods of Cordyceps militaris (L.) Link. or Cordyceps militaris and polypeptide products also more and more are subjected to people's attention.But Chinese caterpillar fungus mostly is wild-type greatly, can not satisfy people's demand.Commercially available worm grass product mostly is to be produced by the Chinese caterpillar fungus or the Cordyceps militaris of artificial culture at present.And polypeptide products is to produce from natural animal and plant, produces the starting material source and enriches, and cost is low, but effect is not comprehensive, does not have the product of polypeptide and the common prescription of Chinese caterpillar fungus in the prior art.
Summary of the invention
The purpose of this invention is to provide a kind of cordyceps polypeptide product that inserts Cordyceps militaris spawn with silkworm chrysalis or egg as substratum and its production and application.
The present invention is that the technical scheme that achieves the above object is: a kind of cordyceps polypeptide product, and, insert Cordyceps militaris spawn and cultivate as substratum with silkworm chrysalis or egg as raw material, make after handling through degreasing, enzymic hydrolysis.
Concrete preparation method is: (1), preparation starting material: silkworm chrysalis or egg as substratum, are inserted Cordyceps militaris spawn, and temperature is controlled at 15 ℃～30 ℃, humidity 70%～90%, cultivates cultivation in 30 days～60 days and obtains silkworm chrysalis Cordyceps sinensis or egg Chinese caterpillar fungus; (2), degreasing: silkworm chrysalis Cordyceps sinensis or egg Chinese caterpillar fungus are carried out boiling and squeezing degreasing; (3), powder process: solids and proteinaceous degreasing muddy water to silkworm chrysalis Cordyceps sinensis after the degreasing or egg Chinese caterpillar fungus carry out drying, pulverizing, make degreasing silkworm chrysalis Cordyceps sinensis powder or egg Chinese caterpillar fungus powder; (4), enzymic hydrolysis: the water that in silkworm chrysalis Cordyceps sinensis powder or egg Chinese caterpillar fungus powder, adds 8～10 times of its weight, the neutral protease that adds silkworm chrysalis Cordyceps sinensis powder or egg Chinese caterpillar fungus grain weight amount 0.5%～2% again, temperature is controlled at 40 ℃～60 ℃ and constantly stirs, through the extremely complete enzymolysis of 8h～24h; (5), the enzyme that goes out: be warmed up to more than 80 ℃ through 3～15 minutes; (6), extract finished product: to feed liquid carry out centrifugation, concentrate, drying makes product.
Cordyceps polypeptide product of the present invention can be used for medicine, healthcare products, food or agricultural biological goods.
The present invention adopts the advantage after the technique scheme to be:
1, the present invention with silkworm chrysalis or egg as substratum, inserting Cordyceps militaris spawn cultivates as raw material, after biochemical treatment, make, be rich in polypeptide, amino acid, cordycepin, cordycepic acid, adenosine, Cordyceps polysaccharide, VITAMIN isoreactivity composition, have very high edible and medical value.Have tangible calmness, anti-inflammatory, anti-hypoxia, antifatigue, anti-ageing, antitumor, antiviral, raise immunity, treatment irregular pulse, regulate lipid metabolism, beautifying face and moistering lotion, antitussive and antiasthmatic, timid phlegm spasmolysis, protect the liver kidney-nourishing, curative effects such as treatment ephritis and renal failure, sexual function improvement, heart and brain pipe, nerve, internal secretion, internal organs, hematopoiesis, immune metabolic system are all had the balance of effect, coordinative role.
2, raw material sources of the present invention are extensive, and production technique is simple, and are with short production cycle, and tooling cost is low, are easy to push away expand and popular consumers demand.
3, the present invention makes silkworm chrysalis Cordyceps sinensis or egg Chinese caterpillar fungus from natural animal and plant, and extracts cordyceps polypeptide product with enzymatic protein, does not have toxicity and side effect, but life-time service.
4, the present invention is by Cordyceps militaris (L.) Link. fungus and the combination of high protein material, and both play a role to make it, and its function is comprehensive, effect is big, because peptide molecule is little, is easy to absorb, and its bioavailability is higher than protein far away, and chinese caterpillar fungus polypeptide is at micro-and lower concentration 10
-9To 10
-12The unique physiological action of performance can also can play a role when the milligram level under the situation of mol/L.
Embodiment
The present invention is further illustrated below in conjunction with embodiment:
Embodiment 1
(1), preparation starting material: silkworm chrysalis or egg as substratum, are inserted Cordyceps militaris spawn, and temperature is controlled at 20 ℃～30 ℃, humidity 80%～90%, cultivates 40 days～60 days, and cultivation obtains silkworm chrysalis Cordyceps sinensis or egg Chinese caterpillar fungus.(2), degreasing: silkworm chrysalis Cordyceps sinensis or egg Chinese caterpillar fungus are carried out boiling and squeezing degreasing, obtain solid materials and oil-water mixture, and oil-water mixture is carried out centrifugation, obtain grease and proteinaceous degreasing muddy water.(3), powder process: solid materials and proteinaceous degreasing muddy water to silkworm chrysalis Cordyceps sinensis after the degreasing or egg Chinese caterpillar fungus carry out drying, pulverizing, make degreasing silkworm chrysalis Cordyceps sinensis powder or egg Chinese caterpillar fungus powder.(4), enzymic hydrolysis: add the water of 8～10 times of its weight in silkworm chrysalis Cordyceps sinensis powder or egg Chinese caterpillar fungus powder, add the neutral protease of silkworm chrysalis Cordyceps sinensis powder or egg Chinese caterpillar fungus grain weight amount 1% again, temperature is controlled at 50 ℃～60 ℃ and constantly stirs, through the extremely complete enzymolysis of 16h～22h; (5), the enzyme that goes out: be warmed up to 90 ℃ through 4～6 minutes; (6), extract finished product: the hydrolysis feed liquid is carried out centrifugation, get product after enriched material is spray-dried.These goods contain following component, and by weight percentage: polypeptide 50%～60%, amino acid 30%～35%, cordycepin 0.3%～0.5%, cordycepic acid 9%～10%, adenosine 0.2%～0.3%, ash 12%～13%, all the other are water.
Embodiment 2
(1), preparation starting material: silkworm chrysalis or duck's egg as substratum, are inserted Cordyceps militaris spawn, and temperature is controlled at 20 ℃～25 ℃, humidity 70%～80%, cultivates 45 days～55 days, and cultivation obtains silkworm chrysalis Cordyceps sinensis or egg Chinese caterpillar fungus.(2), degreasing: silkworm chrysalis Cordyceps sinensis or egg Chinese caterpillar fungus are carried out boiling and squeezing degreasing, obtain solid materials and oil-water mixture, and oil-water mixture is carried out centrifugation, obtain grease and proteinaceous degreasing muddy water.(3), powder process: solid materials and proteinaceous degreasing muddy water to silkworm chrysalis Cordyceps sinensis after the degreasing or egg Chinese caterpillar fungus carry out drying, pulverizing, make degreasing silkworm chrysalis Cordyceps sinensis powder or egg Chinese caterpillar fungus powder.(4), enzymic hydrolysis: add the water of 9 times of its weight in silkworm chrysalis Cordyceps sinensis powder or egg Chinese caterpillar fungus powder, add the neutral protease of silkworm chrysalis Cordyceps sinensis powder or egg Chinese caterpillar fungus grain weight amount 1.5% again, temperature is controlled at 45 ℃～50 ℃ and constantly stirs, through the extremely complete enzymolysis of 18h～20h; (5), the enzyme that goes out: be warmed up to 85 ℃ through 8～10 minutes; (6), extract finished product: the hydrolysis feed liquid is carried out centrifugation, get product after enriched material is spray-dried.These goods contain following component, and by weight percentage: polypeptide 45%～55%, amino acid 25%～35%, cordycepin 0.1%～0.4%, cordycepic acid 8%～9%, adenosine 0.1%～0.15%, ash 10%～12%, all the other are water.
Embodiment 3
(1), preparation starting material: silkworm chrysalis or quail egg as substratum, are inserted Cordyceps militaris spawn, and temperature is controlled at 15 ℃～25 ℃, humidity 75%～85%, cultivates 40 days～50 days, and cultivation obtains silkworm chrysalis Cordyceps sinensis or egg Chinese caterpillar fungus.(2), degreasing: silkworm chrysalis Cordyceps sinensis or egg Chinese caterpillar fungus are carried out boiling and squeezing degreasing, obtain solid materials and oil-water mixture, and oil-water mixture is carried out centrifugation, obtain grease and proteinaceous degreasing muddy water.(3), powder process: solid materials and proteinaceous degreasing muddy water to silkworm chrysalis Cordyceps sinensis after the degreasing or egg Chinese caterpillar fungus carry out drying, pulverizing, make degreasing silkworm chrysalis Cordyceps sinensis powder or egg Chinese caterpillar fungus powder.(4), enzymic hydrolysis: add the water of 9.5 times of its weight in silkworm chrysalis Cordyceps sinensis powder or egg Chinese caterpillar fungus powder, add the neutral protease of silkworm chrysalis Cordyceps sinensis powder or egg Chinese caterpillar fungus grain weight amount 0.8% again, temperature is controlled at 40 ℃～50 ℃ and constantly stirs, through the extremely complete enzymolysis of 10h～18h; (5), the enzyme that goes out: be warmed up to 85 ℃ through 6～10 minutes; (6), extract finished product: the hydrolysis feed liquid is carried out centrifugation, get product after enriched material is spray-dried.These goods contain following component, and by weight percentage: polypeptide 40%～60%, amino acid 20%～40%, cordycepin 0.1%～0.5%, cordycepic acid 8%～10%, adenosine 0.1%～0.3%, ash 10%～15%, all the other are water.
Above-mentioned eggs also can be selected pigeon egg, goose egg etc. for use.
Above-mentioned neutral protease is the commercially available prod, and the required proteolytic enzyme of enzymic hydrolysis also can adopt papain or trypsinase etc.
Cordyceps polypeptide product of the present invention is as single agent raw material or preparation raw material, and can use should be in medicine, healthcare products, food or agricultural biological goods.Can be used for protecting cardiovascular systems on medicinal, relieving asthma and eliminate the phlegm and anti-inflammatory, sedative effect, increase immunologic function, antitumor action etc.In varieties of food items, beverage, healthcare products, be blended into cordyceps polypeptide product by a certain percentage, make various food, beverage and healthcare products, but antifatigue, anti-ageing raising immunizing power etc.Can be used as veterinary formulations at the agricultural biological goods, can prevent and treat virus and improve immunologic function, also can be used as the agricultural biological agricultural chemicals, can prevent and treat crop virus, bacterium focus, can make crop yield more than 10%.
Claims (4)
1, a kind of cordyceps polypeptide product is characterized in that:, insert Cordyceps militaris spawn and cultivate as raw material as substratum with silkworm chrysalis or egg, make after handling through degreasing, enzymic hydrolysis.
2, cordyceps polypeptide product according to claim 1, it is characterized in that: these goods contain following component, and by weight percentage: polypeptide 40%～60%, amino acid 20%～40%, cordycepin 0.1%～0.5%, cordycepic acid 8%～10%, adenosine 0.1%～0.3%, ash 10%～15%, all the other are water.
3, a kind of preparation method of chinese caterpillar fungus polypeptide, it is characterized in that: (1), preparation starting material: with silkworm chrysalis or egg as substratum, insert Cordyceps militaris spawn, temperature is controlled at 15 ℃～30 ℃, humidity 70%～90%, cultivates and obtains silkworm chrysalis Cordyceps sinensis or egg Chinese caterpillar fungus in 30 days～60 days; (2), degreasing: silkworm chrysalis Cordyceps sinensis or egg Chinese caterpillar fungus are carried out boiling and squeezing degreasing; (3), powder process: solids and proteinaceous degreasing muddy water to silkworm chrysalis Cordyceps sinensis after the degreasing or egg Chinese caterpillar fungus carry out drying, pulverizing, make degreasing silkworm chrysalis Cordyceps sinensis powder or egg Chinese caterpillar fungus powder; (4), enzymic hydrolysis: the water that in silkworm chrysalis Cordyceps sinensis powder or egg Chinese caterpillar fungus powder, adds 8～10 times of its weight, the neutral protease that adds silkworm chrysalis Cordyceps sinensis powder or egg Chinese caterpillar fungus grain weight amount 0.5%～2% again, temperature is controlled at 40 ℃～60 ℃ and constantly stirs, through the extremely complete enzymolysis of 8h～24h; (5), the enzyme that goes out: be warmed up to more than 80 ℃ through 3～15 minutes; (6), extract finished product: to feed liquid carry out centrifugation, concentrate, drying makes product.
4, a kind of application of cordyceps polypeptide product is characterized in that: cordyceps polypeptide product can be used for medicine, healthcare products, food or agricultural biological goods.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100409616A CN1314813C (en) | 2005-07-11 | 2005-07-11 | Cordyceps polypeptide product and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100409616A CN1314813C (en) | 2005-07-11 | 2005-07-11 | Cordyceps polypeptide product and its preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1724682A true CN1724682A (en) | 2006-01-25 |
| CN1314813C CN1314813C (en) | 2007-05-09 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2005100409616A Expired - Fee Related CN1314813C (en) | 2005-07-11 | 2005-07-11 | Cordyceps polypeptide product and its preparation method and application |
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| CN (1) | CN1314813C (en) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102526698A (en) * | 2012-01-05 | 2012-07-04 | 苟春虎 | Cordyceps polypeptide amino acid nutrient solution |
| CN102813193A (en) * | 2012-07-25 | 2012-12-12 | 江苏科技大学 | Chinese caterpillar fungus cyanine oral liquid and preparation method thereof |
| CN102987408A (en) * | 2012-10-17 | 2013-03-27 | 徐州鸿宇农业科技有限公司 | Method for extracting nutritional ingredients such as free amino acids from waste cordyceps militaris cocoons |
| CN103194516A (en) * | 2013-03-17 | 2013-07-10 | 赤峰鼎基生物工程科技有限公司 | Preparation method of cordyceps militaris polypeptide |
| CN103961681A (en) * | 2014-05-14 | 2014-08-06 | 伍彪 | Cordyceps militaris polypeptide composition as well as preparation method and application thereof |
| CN105854002A (en) * | 2016-01-15 | 2016-08-17 | 上海荣神生物化学有限公司 | Polypeptide powder composition and tablet and preparation method thereof |
| CN106072632A (en) * | 2016-06-15 | 2016-11-09 | 钱卫文 | A kind of Ganoderma extract and its preparation method and application |
| CN106434806A (en) * | 2016-09-30 | 2017-02-22 | 北华大学 | Cordyceps militaris polypeptide as well as preparation method and applications thereof |
| CN106606773A (en) * | 2015-10-16 | 2017-05-03 | 镇江市天益生物科技有限公司 | Production method of cordyceps militaris polypeptide tablets |
| CN107028184A (en) * | 2017-03-21 | 2017-08-11 | 江苏又宁生物科技有限公司 | A kind of three grass meal products of dietotherapeutic |
| CN107602660A (en) * | 2017-10-31 | 2018-01-19 | 湖北省农业科学院农产品加工与核农技术研究所 | A kind of Cordyceps militaris polypeptide product and preparation method and application |
| CN107638560A (en) * | 2017-07-25 | 2018-01-30 | 赵德润 | A kind of preparation method of edible fungi active peptide |
| CN110477368A (en) * | 2019-09-25 | 2019-11-22 | 南京高新工大生物技术研究院有限公司 | A kind of high activity cordyceps sinensis powder and the preparation method and application thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1098629A (en) * | 1994-06-04 | 1995-02-15 | 长春市宏兴医药科技开发公司 | A kind of method of being used as medicine with the Antheraea pernyi Geurin Meneville culturing Cordyceps militaris (L.) Link. |
| CN100363012C (en) * | 2002-12-20 | 2008-01-23 | 吕守泰 | Cordyceps sinensis polysaccharide emulsion and preparing method thereof |
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2005
- 2005-07-11 CN CNB2005100409616A patent/CN1314813C/en not_active Expired - Fee Related
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN102813193A (en) * | 2012-07-25 | 2012-12-12 | 江苏科技大学 | Chinese caterpillar fungus cyanine oral liquid and preparation method thereof |
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