CN106606773A - Production method of cordyceps militaris polypeptide tablets - Google Patents
Production method of cordyceps militaris polypeptide tablets Download PDFInfo
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- CN106606773A CN106606773A CN201510679105.9A CN201510679105A CN106606773A CN 106606773 A CN106606773 A CN 106606773A CN 201510679105 A CN201510679105 A CN 201510679105A CN 106606773 A CN106606773 A CN 106606773A
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- production method
- cordyceps militaris
- vitamin
- liver
- militaris
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Abstract
The invention provides a production method of cordyceps militaris polypeptide tablets which are high in practical value and good in combination effect and the production method is allowed for industrial production. According to the adopted technology, the production method is characterized in that the content of active components including reduced glutathione and a cordyceps militaris extract can be controlled, thereby achieving stable quality.
Description
Technical field
The present invention relates to a kind of production method of Cordyce militaris polypeptide piece, belongs to food processing technology field, particularly health food processing technology.
Background technology
Liver is the most important removing toxic substances organ of human body, and its contained glutathion shields to hepatocellular synthesis, removing toxic substances, estrogen inactivation etc..
When liver sustains damage, such as when with various hepatopathys, the liver that human body helps injury by substantial amounts of glutathion is consumed carries out self-regeneration reconciliation
Poison, internal glutathion will fall sharply.Due to hepatocyte nutrient and hepatocyte energy deficiency, body constitution will be caused to decline.Ethanol also can be made
Reduce into liver function, the toxicity of ethanol causes headache, lethargy, Nausea and vomiting.The factor of other external environment pollutions can also produce toxicity into human body
Effect, autologous metabolism can also produce detoxification substance, and the Detoxication of liver lacks, and body constitution will be caused to decline.Liver-fire too two rubescent, fatigues of distinguished gathering
Powerless, insomnia and immunity degradation；Often there are uncomfortable liver area, the gloomy sensation of pain.They are the performances that toxicant is retarded by silt in liver.
Cordyceps militaris can mitigate hepatocyte injury caused by the various factors such as chemical substance, medicine, virus, reduce the liver functions such as transaminase, bilirubin
Index；Raise the liver complex functionality indexs such as blood albumin.Meanwhile, Cordycepses reduce and liver cirrhosis have directly by suppressing the gene expressions of TGF β 1
The PDGF gene expressions of relation, suppress main pathological change --- the hepatic fibrosis of liver cirrhosis, mitigate even reverse cirrhosis.By adjusting " solution
Coupling protein 2 (UCP2) " level, mitigates endotoxemia, tumor necrosis factor α (TNF α) is reduced, so as to suppress fatty liver.
Reduced glutathion is to strengthening the organ functions such as people body-centered, liver, kidney, brain, enhance immunity, free radical resisting, defying age, cancer-resisting
And relieving alcohol hepatic injury has obvious biological effect.It participates in biotransformation and poisonous substance harmful in vivo is changed into harmless material, protects
Not by the harmful substance Oxidative demage such as such as free radical in shield numerous protein and enzyme equimolecular.
Vitamin B1 is the constituent of various coenzyme in human body, participates in carbohydrate metabolism metabolism, and safeguards digestive system, nervous system and cyclic system
The normal function of system.Vitamin B2 participates in the growth metabolism of cell, is when injected organism tissue metabolism and necessary the nutrient repaired, such as strengthen liver function,
Adjust adrenergic secretion.Vitamin C-kind of water miscible strong antioxidant, as long as VC is sufficient, then VC, glutathion ,-SH shapes
Into strong antioxidation set boxing, free radical is removed, prevent lipid peroxidation and the toxic action of some chemical substances, liver-protective detoxification ability
With the homergy of cell.
So selecting Cordyceps militaris, reductive glutathione, Vitamin E, effectively combination is formed rationally, making Cordyce militaris polypeptide piece has important meaning
Justice, product of the present invention provides human hepatocyte's factor and the necessary nutrient of human body, by with reference to poisonous chemical substance, increasing its dissolubility,
Progressively discharge, and play the role of to solve liver poison.
The content of the invention
It is an object of the invention to provide a kind of production method of the Cordyce militaris polypeptide piece that practical value is high, combined effect is good, into industrialized production.This
The technology that invention is adopted, is characterized in that active component-reduced glutathion, the content of Cordyceps militaris extract can be controlled, and reach stay-in-grade
Purpose.
For achieving the above object, the technical solution used in the present invention is as follows：
A kind of production method of Cordyce militaris polypeptide piece, comprising following component and weight proportion：Cordyceps militaris extract 300mg, reduced glutathion
50mg, vitamin B13mg, vitamin B20.5mg, vitamin C 12.5mg；With Mannitol 75mg as protective agent, add corn starch 32.5mg,
Microcrystalline Cellulose 25mg, magnesium stearate 1.5mg.
A kind of production method of Cordyce militaris polypeptide piece, its step is as follows：
(1) Cordyceps militaris obtain Cordyceps militaris extract Jing water extraction, concentration, after being spray-dried；
(2) with Mannitol as protective agent, addition Microcrystalline Cellulose, magnesium stearate mix, sieving obtains compositionss, are processed on tablet machine
Cordyce militaris polypeptide piece；
(3) under gmp conditions through sterilizing, packing, checking, dispatching from the factory.
Effective active composition in Cordyceps militaris of the present invention includes the multiple biological activities things such as cordycepin, cordycepic acid, Cordyceps polysaccharide, superoxide dismutase
Matter.Cordycepin, i.e. 3'-Deoxyadenosine, it is similar with gland glycoside action, it is a kind of nucleosides material with antibacterial activity, it is poly- to core polyadenylic acid
Synthase has very strong inhibitory action, the activity with antiviral, antibacterial.Cordycepic acid, i.e. Mannitol, can suppress the growth of various pathogenic bacterias, promote machine
The metabolism of body.Superoxide dismutase, is a kind of very important antioxidase, and it can help eliminate excessive free radical in vivo, it is to avoid
Cell is aoxidized, aging or destruction, is also waited and is suppressed virus, strengthens immunologic function.Cordyceps polysaccharide has immunocompetence, can be remarkably reinforced body fluid with
Cellular immune function, promotes generation or the antigen precursor reactant of antibody and interferon.
Compared with prior art, the invention has the advantages that：
(1) it is a kind of special nutrient troche, is the good friend of liver；
(2) using reduced glutathion and the quality control of Cordyceps militaris extract, product is conducive to move towards international market；
(3) long shelf-life of product, stable components, taking convenience, with feasibility, also containing the necessary trace element of the human bodies such as Vitamin E,
With the health-care effect for promoting immunity of organisms.
(4) product of the present invention provides hepatocellular important factor and the necessary nutrient of human body, by with reference to poisonous chemical substance, increasing
Its dissolubility, progressively excretes, and plays the effect of solution liver poison.So, there is auxiliary protection function to hepatic injury.
Effect of the invention is that：By the way that Cordyceps militaris extract, reduced glutathion, vitamin B1, vitamin B2, vitamin C etc. is main
Composition is wanted to form reasonable combination, there is provided human hepatocyte's factor and the necessary nutrient of human body, by with reference to poisonous chemical substance, increasing its molten
Xie Xing, progressively discharges, and plays the role of to solve liver poison.
Specific embodiment
Embodiment 1：
The present embodiment Cordyce militaris polypeptide piece includes following component and weight proportion：Cordyceps militaris extract 300mg, reduced glutathion 50mg, dimension
Raw element B13mg, vitamin B20.5mg, vitamin C 12.5mg；With Mannitol 75mg as protective agent, add corn starch 32.5mg, crystallite
Cellulose 25mg, magnesium stearate 1.5mg.This weight ratio is the material content for producing 0.5g/ per piece.
1st, Cordyceps militaris obtain Cordyceps militaris extract Jing water extraction, concentration, after being spray-dried；
2nd, it is the raw material in every 0.5g to appeal weight ratio, produces 10,000, it is necessary to be multiplied by 10,000 times.Add magnesium stearate, corn starch,
Mannitol, Microcrystalline Cellulose etc. are sufficiently mixed.
3rd, according to their weight ratio, mix, sieving obtains compositionss, and Cordyce militaris polypeptide piece is processed on tablet machine under G M P-conditions,
Can be with mmic package, it is also possible to which 6-12 sheet panels are packed.Through sterilizing, packing, check, dispatch from the factory.
Above-described embodiment is not restricted to the described embodiments for the present invention preferably embodiment, but embodiments of the present invention, and others are any not to carry on the back
Spirit and the change, modification, replacement made under principle from the present invention, combine, simplification, should be equivalent substitute mode, be included in
Protection scope of the present invention.
Claims (3)
1. a kind of production method of Cordyce militaris polypeptide piece, it is characterised in that comprising following component and weight proportion：Cordyceps militaris extract 300mg,
Reduced glutathion 50mg, vitamin B13mg, vitamin B20.5mg, vitamin C 12.5mg；With Mannitol 75mg as protective agent, add
Plus corn starch 32.5mg, Microcrystalline Cellulose 25mg, magnesium stearate 1.5mg, mix, sieving obtains compositionss, and north is processed on tablet machine
Chinese caterpillar fungus polypeptide piece；Under gmp conditions through sterilizing, packing, checking, dispatching from the factory.
2. the production method of a kind of Cordyceps militaris according to claim 1, it is characterised in that：The purity of reduced glutathion is more than 98%.
3. the production method of a kind of Cordyceps militaris according to claim 1, it is characterised in that：Vitamin B1Purity more than 98%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510679105.9A CN106606773A (en) | 2015-10-16 | 2015-10-16 | Production method of cordyceps militaris polypeptide tablets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510679105.9A CN106606773A (en) | 2015-10-16 | 2015-10-16 | Production method of cordyceps militaris polypeptide tablets |
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| CN106606773A true CN106606773A (en) | 2017-05-03 |
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| CN201510679105.9A Pending CN106606773A (en) | 2015-10-16 | 2015-10-16 | Production method of cordyceps militaris polypeptide tablets |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1724682A (en) * | 2005-07-11 | 2006-01-25 | 钱卫文 | Cordyceps polypeptide product and its preparation method and application |
| CN103652846A (en) * | 2012-09-25 | 2014-03-26 | 江苏学府生物工程有限公司 | Production method for cordyceps militaris buccal tablets |
| CN103652932A (en) * | 2012-09-07 | 2014-03-26 | 江苏学府生物工程有限公司 | Production method of Cordyceps militaris polypeptide tablet |
| CN103652940A (en) * | 2012-09-07 | 2014-03-26 | 江苏学府生物工程有限公司 | Production method of Cordyceps militaris polypeptide soft capsule |
| CN104403012A (en) * | 2014-11-10 | 2015-03-11 | 苏州蔻美新材料有限公司 | Extraction technology of cordyceps militaris polysaccharide and polypeptide |
-
2015
- 2015-10-16 CN CN201510679105.9A patent/CN106606773A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1724682A (en) * | 2005-07-11 | 2006-01-25 | 钱卫文 | Cordyceps polypeptide product and its preparation method and application |
| CN103652932A (en) * | 2012-09-07 | 2014-03-26 | 江苏学府生物工程有限公司 | Production method of Cordyceps militaris polypeptide tablet |
| CN103652940A (en) * | 2012-09-07 | 2014-03-26 | 江苏学府生物工程有限公司 | Production method of Cordyceps militaris polypeptide soft capsule |
| CN103652846A (en) * | 2012-09-25 | 2014-03-26 | 江苏学府生物工程有限公司 | Production method for cordyceps militaris buccal tablets |
| CN104403012A (en) * | 2014-11-10 | 2015-03-11 | 苏州蔻美新材料有限公司 | Extraction technology of cordyceps militaris polysaccharide and polypeptide |
Non-Patent Citations (1)
| Title |
|---|
| 潘卫三: "《工业药剂学》", 31 August 2015, 中国医药科技出版社 * |
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Application publication date: 20170503 |
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