CN103961681B - A kind of cordyceps polypeptide composition and method of making the same and application - Google Patents
A kind of cordyceps polypeptide composition and method of making the same and application Download PDFInfo
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Abstract
The invention provides a kind of cordyceps polypeptide composition and method of making the same and application, described product and composition thereof comprise 10～45 parts of the northern Chinese caterpillar Fungus of weight portion, 5～15 parts of oyster polypeptide powders, 1～5 part of corn Gly-His-Lys, 12～43 parts, sheep kidney, 4～12 parts of donkey whips, 20～28 parts of mulberries, 5～19 parts of thes membrane of a chicken's gizzard, 2～10 parts of perilla leafs, 2～9 parts of lotus roots, 1～6 part of hawthorn, 1～8 part, cabbage, 13～28 parts, leek, 5～15 parts of pollen pinis, 1～5 part of the seed of Job's tears, 3～10 parts, tomato, 5～19 parts of dandelions, 9～20 parts of roses, 0.01～0.6 part of ferrous fumarate, 0.01～0.6 part of zinc lactate, the Chinese medicine of 0.01～0.6 part of medicine-food two-purpose such as grade of yeast selenium, biological polypeptide. the present invention can be applied to preparation and improve moisture of skin, alleviating asthenopia, functions of removing chloasma, improves the health food of sexual function or for the preparation of Cure of depression, hyperplasia of prostate medicine.
Description
Technical field
The present invention relates to field of medicaments, be specifically related to a kind of cordyceps polypeptide composition with and preparation method thereof, relate to a kind of Chinese caterpillar fungus manyPeptide combinations is applied to preparation and improves moisture of skin, alleviating asthenopia, functions of removing chloasma, the health food that improves sexual function or useIn preparing Cure of depression, hyperplasia of prostate medicine.
Background technology
Northern Chinese caterpillar Fungus is Ascomycotina, ergot Zoopagales, the type sepecies of Clavicipitaceae, Cordyceps. Formal name used at school isCordycepsmilitaris, has another name called Cordyceps militaris, northern Chinese caterpillar fungus etc. Worldwide distribution natural resources quantity is little. By stroma (Grass part) and sclerotium (being the corpse part of worm) complex dimerous. Winter, larva lived in seclusion in soil, mushroom parasitic itsIn, draw nutrition, in larva body, be full of mycelia and dead. To summer, on larva corpse, bear seedling, likeness in form grass, summerGather to front and back and obtain. The traditional Chinese medical science thinks, Chinese caterpillar fungus enters lung kidney two warps, can tonifying lung the moon, again can kidney-replenishing, and cure mainly and suffer from a deficiency of the kidney, impotenceSeminal emission, soreness of waist and knee joint, weak after being ill, chronic cough weakness, phthisical cough phlegm blood, spontaneous sweating etc., be unique one simultaneously balance,Regulate the Chinese medicine of negative and positive. North Chinese caterpillar fungus, than Cordyceps sinensis, has several unrivaled advantages: the one, and northern Chinese caterpillar fungus is CordycepsType sepecies, widely distributed, by countries in the world scholar is familiar with and is accepted. The 2nd, northern Chinese caterpillar fungus has been bred as complete under artificial conditionStroma. The 3rd, northern Chinese caterpillar fungus contains cordycepin and Cordyceps sinensis polysaccharide, and its unique pharmacological action causes the great attention of pharmacy circle day by day.Because Cordyceps militaris has above advantage, become the outstanding person in medicinal Cordyceps Militaris in Cordyceps. People are just simply by it at presentAs food, the one, the compatibility of shortage science and synergy, the 2nd, take inconvenience. Meanwhile, at present, dry skin, lookFatigue, chloasma, sexual disorder and depression, the life that the cold snow in palace is cold, hyperplasia of prostate has had a strong impact on people. CauseThis, select suitable raw material carry out rational compatibility, prepare and be applied to preparation improve moisture of skin, alleviating asthenopia, the Huang of dispellingFoxiness, improve the health food of sexual function or become and a kind of objectively need for the preparation of Cure of depression, hyperplasia of prostate medicineAsk.
Summary of the invention
The present invention is intended to address the above problem, and the first object is to provide a kind of plurality of raw materials is carried out to reasonable formula, can fully haveEffect of raw material ingredient is brought into play and is utilized on effect ground, integrates the cordyceps polypeptide composition for the treatment of and health care, the second orderThe preparation method who is to provide a kind of cordyceps polypeptide composition, the 3rd object be to provide a kind of cordyceps polypeptide composition preparationImprove moisture of skin, alleviating asthenopia, functions of removing chloasma, improve in the health food of sexual function and apply, the 4th object is to provideA kind of cordyceps polypeptide composition is in the application of preparing in Cure of depression, hyperplasia of prostate medicine.
For achieving the above object, the invention provides a kind of cordyceps polypeptide composition, the raw material that said composition contains following weight portion:
10～45 parts of northern Chinese caterpillar Fungus, 5～15 parts of oyster polypeptide powders, 1～5 part of corn Gly-His-Lys, 12～43 parts, sheep kidney, donkey whip 4～12 parts, 20～28 parts of mulberries, 5～19 parts of thes membrane of a chicken's gizzard, 2～10 parts of perilla leafs, 2～9 parts of lotus roots, 1～6 part of hawthorn, volume1～8 part of heart dish, 13～28 parts, leek, 5～15 parts of pollen pinis, 1～5 part of the seed of Job's tears, 3～10 parts, tomato, dandelion 5～19 parts, 9～20 parts of roses, 0.01～0.6 part of ferrous fumarate, 0.01～0.6 part of zinc lactate, yeast selenium 0.01～0.6Part.
The invention provides a kind of preparation method of cordyceps polypeptide composition, it is characterized in that carrying out as follows:
(1) take by weight 10～45 parts of northern Chinese caterpillar Fungus, 5～15 parts of oyster polypeptide powders, 1～5 part of corn Gly-His-Lys, sheep kidney12～43 parts, 4～12 parts of donkey whips, 20～28 parts of mulberries, 5～19 parts of thes membrane of a chicken's gizzard, 2～10 parts of perilla leafs, 2～9 parts of lotus roots,1～6 part of hawthorn, 1～8 part, cabbage, 13～28 parts, leek, 5～15 parts of pollen pinis, 1～5 part of the seed of Job's tears, tomato 3～10 parts, 5～19 parts of dandelions, 9～20 parts of roses, 0.01～0.6 part of ferrous fumarate, 0.01～0.6 part of zinc lactate,0.01～0.6 part of yeast selenium, for subsequent use;
(2) the membrane of a chicken's gizzard, pollen pini, the seed of Job's tears are pulverized, crossed 200 mesh sieves, for subsequent use;
(3) sheep kidney, donkey whip and hawthorn are got 1 time by 5～8 times of water extractions, each 2 hours, filter the another device storage of filtrate;
(4) by filter residue in above-mentioned (3), add northern Chinese caterpillar Fungus, mulberries, perilla leaf, lotus root, cabbage, leek, tomato,Dandelion, rose, get 2 times by 8～12 times of water extractions, each 1～3 hour, filters the another device storage of filtrate;
(5) merge filtrate in above-mentioned (3) and (4), reduced pressure concentration, dry, the dried cream powder making is ground into 80～100 orders,For subsequent use;
(6) in above-mentioned (5), in dried cream powder, add material in above-mentioned (2), oyster polypeptide powder, corn Gly-His-Lys, ferrous fumarate,Zinc lactate, yeast selenium and proper auxiliary materials, make tablet, capsule, granule, oral liquid.
The invention provides a kind of cordyceps polypeptide composition is applied to preparation and improves moisture of skin, alleviating asthenopia, functions of removing chloasma, changesThe health food of kind sexual function.
The invention provides a kind of cordyceps polypeptide composition is applied to and prepares Cure of depression, hyperplasia of prostate medicine.
Embodiment 1
10 parts of northern Chinese caterpillar Fungus, 5 parts of oyster polypeptide powders, 1 part of corn Gly-His-Lys, 12 parts, sheep kidney, 8 parts of donkey whips, 24 parts of mulberries, chickenInterior golden 14 parts, 6 parts of perilla leafs, 5 parts of lotus roots, 4 parts of hawthorn, 5 parts, cabbage, 18 parts, leek, 8 parts of pollen pinis, the seed of Job's tears3 parts, 6 parts, tomato, 19 parts of dandelions, 20 parts of roses, 0.6 part of ferrous fumarate, 0.6 part of zinc lactate, yeast0.6 part, selenium.
Preparation method:
(1) take by weight 10 parts of northern Chinese caterpillar Fungus, 5 parts of oyster polypeptide powders, 1 part of corn Gly-His-Lys, 12 parts, sheep kidney, donkey whip 8Part, 24 parts of mulberries, 14 parts of thes membrane of a chicken's gizzard, 6 parts of perilla leafs, 5 parts of lotus roots, 4 parts of hawthorn, 5 parts, cabbage, 18 parts, leek,8 parts of pollen pinis, 3 parts of the seeds of Job's tears, 6 parts, tomato, 19 parts of dandelions, 20 parts of roses, 0.6 part of ferrous fumarate, breast0.6 part, acid zinc, 0.6 part of yeast selenium, for subsequent use;
(2) the membrane of a chicken's gizzard, pollen pini, the seed of Job's tears are pulverized, crossed 200 mesh sieves, for subsequent use;
(3) sheep kidney, donkey whip and hawthorn are got 1 time by 6 times of water extractions, each 2 hours, filter the another device storage of filtrate;
(4) by filter residue in above-mentioned (3), add northern Chinese caterpillar Fungus, mulberries, perilla leaf, lotus root, cabbage, leek, tomato,Dandelion, rose, get 2 times by 10 times of water extractions, each 2 hours, filters the another device storage of filtrate;
(5) merge filtrate in above-mentioned (3) and (4), reduced pressure concentration, dry, the dried cream powder making is ground into 90 orders, for subsequent use;(6) in above-mentioned (5), in dried cream powder, add material in above-mentioned (2), oyster polypeptide powder, corn Gly-His-Lys, ferrous fumarate,Zinc lactate, yeast selenium and proper auxiliary materials, wet method granulation, sieves, dry, whole grain, packaging, inspection, warehouse-in, makesGranule.
Embodiment 2
33 parts of northern Chinese caterpillar Fungus, 11 parts of oyster polypeptide powders, 3 parts of corn Gly-His-Lys, 28 parts, sheep kidney, 12 parts of donkey whips, 28 parts of mulberries,19 parts of thes membrane of a chicken's gizzard, 10 parts of perilla leafs, 9 parts of lotus roots, 6 parts of hawthorn, 8 parts, cabbage, 28 parts, leek, 15 parts of pollen pinis,5 parts of the seeds of Job's tears, 10 parts, tomato, 5 parts of dandelions, 9 parts of roses, 0.01 part of ferrous fumarate, 0.01 part of zinc lactate,0.01 part of yeast selenium.
Preparation method:
(1) take by weight 33 parts of northern Chinese caterpillar Fungus, 11 parts of oyster polypeptide powders, 3 parts of corn Gly-His-Lys, 28 parts, sheep kidney, donkey whip12 parts, 28 parts of mulberries, 19 parts of thes membrane of a chicken's gizzard, 10 parts of perilla leafs, 9 parts of lotus roots, 6 parts of hawthorn, 8 parts, cabbage, leek 28Part, 15 parts of pollen pinis, 5 parts of the seeds of Job's tears, 10 parts, tomato, 5 parts of dandelions, 9 parts of roses, 0.01 part of ferrous fumarate,0.01 part of zinc lactate, 0.01 part of yeast selenium, for subsequent use;
(2) the membrane of a chicken's gizzard, pollen pini, the seed of Job's tears are pulverized, crossed 200 mesh sieves, for subsequent use;
(3) sheep kidney, donkey whip and hawthorn are got 1 time by 8 times of water extractions, each 2 hours, filter the another device storage of filtrate;
(4) by filter residue in above-mentioned (3), add northern Chinese caterpillar Fungus, mulberries, perilla leaf, lotus root, cabbage, leek, tomato,Dandelion, rose, get 2 times by 8 times of water extractions, each 3 hours, filters the another device storage of filtrate;
(5) merge filtrate in above-mentioned (3) and (4), reduced pressure concentration, dry, the dried cream powder making is ground into 100 orders, for subsequent use;
(6) in above-mentioned (5), in dried cream powder, add material in above-mentioned (2), oyster polypeptide powder, corn Gly-His-Lys, ferrous fumarate,Zinc lactate, yeast selenium and proper auxiliary materials, mix, and packs Capsules into, packaging, and inspection, warehouse-in, makes capsule.
Embodiment 3
45 parts of northern Chinese caterpillar Fungus, 15 parts of oyster polypeptide powders, 5 parts of corn Gly-His-Lys, 43 parts, sheep kidney, 4 parts of donkey whips, 20 parts of mulberries,5 parts of thes membrane of a chicken's gizzard, 2 parts of perilla leafs, 2 parts of lotus roots, 1 part of hawthorn, 1 part, cabbage, 13 parts, leek, 5 parts of pollen pinis, the seed of Job's tears1 part, 3 parts, tomato, 13 parts of dandelions, 16 parts of roses, 0.3 part of ferrous fumarate, 0.3 part of zinc lactate, yeast0.4 part, selenium.
Preparation method:
(1) take by weight 45 parts of northern Chinese caterpillar Fungus, 15 parts of oyster polypeptide powders, 5 parts of corn Gly-His-Lys, 43 parts, sheep kidney, donkey whip4 parts, 20 parts of mulberries, 5 parts of thes membrane of a chicken's gizzard, 2 parts of perilla leafs, 2 parts of lotus roots, 1 part of hawthorn, 1 part, cabbage, 13 parts, leek,5 parts of pollen pinis, 1 part of the seed of Job's tears, 3 parts, tomato, 13 parts of dandelions, 16 parts of roses, 0.3 part of ferrous fumarate, breast0.3 part, acid zinc, 0.4 part of yeast selenium, for subsequent use;
(2) the membrane of a chicken's gizzard, pollen pini, the seed of Job's tears are pulverized, crossed 200 mesh sieves, for subsequent use;
(3) sheep kidney, donkey whip and hawthorn are got 1 time by 7 times of water extractions, each 2 hours, filter the another device storage of filtrate;
(4) by filter residue in above-mentioned (3), add northern Chinese caterpillar Fungus, mulberries, perilla leaf, lotus root, cabbage, leek, tomato,Dandelion, rose, get 2 times by 12 times of water extractions, each 1 hour, filters the another device storage of filtrate;
(5) merge filtrate in above-mentioned (3) and (4), reduced pressure concentration, dry, the dried cream powder making is ground into 80 orders, for subsequent use;
(6) in above-mentioned (5), in dried cream powder, add material in above-mentioned (2), oyster polypeptide powder, corn Gly-His-Lys, ferrous fumarate,Zinc lactate, yeast selenium and proper auxiliary materials, wet method granulation, dry, sieve, whole grain, is pressed into tablet, packaging, inspection,Warehouse-in, makes tablet.
Embodiment 4
30 parts of northern Chinese caterpillar Fungus, 10 parts of oyster polypeptide powders, 5 parts of corn Gly-His-Lys, 25 parts, sheep kidney, 8 parts of donkey whips, 21 parts of mulberries,13 parts of thes membrane of a chicken's gizzard, 10 parts of perilla leafs, 7 parts of lotus roots, 4 parts of hawthorn, 3 parts, cabbage, 26 parts, leek, 10 parts of pollen pinis,2 parts of the seeds of Job's tears, 4 parts, tomato, 11 parts of dandelions, 18 parts of roses, 0.05 part of ferrous fumarate, 0.09 part of zinc lactate,0.1 part of yeast selenium.
Preparation method:
(1) take by weight 30 parts of northern Chinese caterpillar Fungus, 10 parts of oyster polypeptide powders, 5 parts of corn Gly-His-Lys, 25 parts, sheep kidney, donkey whip8 parts, 21 parts of mulberries, 13 parts of thes membrane of a chicken's gizzard, 10 parts of perilla leafs, 7 parts of lotus roots, 4 parts of hawthorn, 3 parts, cabbage, leek 26Part, 10 parts of pollen pinis, 2 parts of the seeds of Job's tears, 4 parts, tomato, 11 parts of dandelions, 18 parts of roses, ferrous fumarate 0.05Part, 0.09 part of zinc lactate, 0.1 part of yeast selenium, for subsequent use;
(2) the membrane of a chicken's gizzard, pollen pini, the seed of Job's tears are pulverized, crossed 200 mesh sieves, for subsequent use;
(3) sheep kidney, donkey whip and hawthorn are got 1 time by 7 times of water extractions, each 2 hours, filter the another device storage of filtrate;
(4) by filter residue in above-mentioned (3), add northern Chinese caterpillar Fungus, mulberries, perilla leaf, lotus root, cabbage, leek, tomato,Dandelion, rose, get 2 times by 11 times of water extractions, each 2.5 hours, filters the another device storage of filtrate;
(5) merge filtrate in above-mentioned (3) and (4), reduced pressure concentration, dry, the dried cream powder making is ground into 100 orders, for subsequent use;
(6) in above-mentioned (5), in dried cream powder, add material in above-mentioned (2), oyster polypeptide powder, corn Gly-His-Lys, ferrous fumarate,Zinc lactate, yeast selenium and proper auxiliary materials, then flavouring in addition, add water to full dose and dissolve, and filters, and bottling, rolls lid, sterilizing,Packaging, inspection, warehouse-in, makes oral liquid.
Embodiment 5
14 parts of northern Chinese caterpillar Fungus, 9 parts of oyster polypeptide powders, 3 parts of corn Gly-His-Lys, 24 parts, sheep kidney, 8 parts of donkey whips, 24 parts of mulberries, chickenInterior golden 14 parts, 9 parts of perilla leafs, 7 parts of lotus roots, 4 parts of hawthorn, 7 parts, cabbage, 23 parts, leek, 13 parts of pollen pinis, the seed of Job's tears4 parts, 9 parts, tomato, 15 parts of dandelions, 15 parts of roses, 0.4 part of ferrous fumarate, 0.3 part of zinc lactate, yeast0.5 part, selenium.
Preparation method:
(1) take by weight 14 parts of northern Chinese caterpillar Fungus, 9 parts of oyster polypeptide powders, 3 parts of corn Gly-His-Lys, 24 parts, sheep kidney, donkey whip 8Part, 24 parts of mulberries, 14 parts of thes membrane of a chicken's gizzard, 9 parts of perilla leafs, 7 parts of lotus roots, 4 parts of hawthorn, 7 parts, cabbage, 23 parts, leek,13 parts of pollen pinis, 4 parts of the seeds of Job's tears, 9 parts, tomato, 15 parts of dandelions, 15 parts of roses, 0.4 part of ferrous fumarate, breast0.3 part, acid zinc, 0.5 part of yeast selenium, for subsequent use;
(2) the membrane of a chicken's gizzard, pollen pini, the seed of Job's tears are pulverized, crossed 200 mesh sieves, for subsequent use;
(3) sheep kidney, donkey whip and hawthorn are got 1 time by 6 times of water extractions, each 2 hours, filter the another device storage of filtrate;
(4) by filter residue in above-mentioned (3), add northern Chinese caterpillar Fungus, mulberries, perilla leaf, lotus root, cabbage, leek, tomato,Dandelion, rose, get 2 times by 9 times of water extractions, each 3 hours, filters the another device storage of filtrate;
(5) merge filtrate in above-mentioned (3) and (4), reduced pressure concentration, dry, the dried cream powder making is ground into 80 orders, for subsequent use;
(6) in above-mentioned (5), in dried cream powder, add material in above-mentioned (2), oyster polypeptide powder, corn Gly-His-Lys, ferrous fumarate,Zinc lactate, yeast selenium and proper auxiliary materials, dry method granulation, sieves, and whole grain, is pressed into tablet, packaging, inspection, warehouse-in,Make tablet.
Embodiment 6
27 parts of northern Chinese caterpillar Fungus, 12 parts of oyster polypeptide powders, 4 parts of corn Gly-His-Lys, 37 parts, sheep kidney, 10 parts of donkey whips, 26 parts of mulberries,8 parts of thes membrane of a chicken's gizzard, 4 parts of perilla leafs, 3 parts of lotus roots, 2 parts of hawthorn, 3 parts, cabbage, 17 parts, leek, 8 parts of pollen pinis, the seed of Job's tears2 parts, 6 parts, tomato, 7 parts of dandelions, 12 parts of roses, 0.08 part of ferrous fumarate, 0.05 part of zinc lactate, yeast0.06 part, selenium.
Preparation method:
(1) take by weight 27 parts of northern Chinese caterpillar Fungus, 12 parts of oyster polypeptide powders, 4 parts of corn Gly-His-Lys, 37 parts, sheep kidney, donkey whip10 parts, 26 parts of mulberries, 8 parts of thes membrane of a chicken's gizzard, 4 parts of perilla leafs, 3 parts of lotus roots, 2 parts of hawthorn, 3 parts, cabbage, 17 parts, leek,8 parts of pollen pinis, 2 parts of the seeds of Job's tears, 6 parts, tomato, 7 parts of dandelions, 12 parts of roses, 0.08 part of ferrous fumarate, breast0.05 part, acid zinc, 0.06 part of yeast selenium, for subsequent use;
(2) the membrane of a chicken's gizzard, pollen pini, the seed of Job's tears are pulverized, crossed 200 mesh sieves, for subsequent use;
(3) sheep kidney, donkey whip and hawthorn are got 1 time by 7 times of water extractions, each 2 hours, filter the another device storage of filtrate;
(4) by filter residue in above-mentioned (3), add northern Chinese caterpillar Fungus, mulberries, perilla leaf, lotus root, cabbage, leek, tomato,Dandelion, rose, get 2 times by 10 times of water extractions, each 1.5 hours, filters the another device storage of filtrate;
(5) merge filtrate in above-mentioned (3) and (4), reduced pressure concentration, dry, the dried cream powder making is ground into 100 orders, for subsequent use;
(6) in above-mentioned (5), in dried cream powder, add material in above-mentioned (2), oyster polypeptide powder, corn Gly-His-Lys, ferrous fumarate,Zinc lactate, yeast selenium and proper auxiliary materials, dry method granulation, sieves, and whole grain, packs Capsules into, packaging, inspection, entersStorehouse, makes capsule.
Embodiment 7
40 parts of northern Chinese caterpillar Fungus, 7 parts of oyster polypeptide powders, 2 parts of corn Gly-His-Lys, 15 parts, sheep kidney, 7 parts of donkey whips, 23 parts of mulberries, chickenInterior golden 11 parts, 6 parts of perilla leafs, 5 parts of lotus roots, 3 parts of hawthorn, 5 parts, cabbage, 20 parts, leek, 11 parts of pollen pinis, the seed of Job's tears3 parts, 7 parts, tomato, 11 parts of dandelions, 13 parts of roses, 0.2 part of ferrous fumarate, 0.1 part of zinc lactate, yeast0.3 part, selenium.
Preparation method:
(1) take by weight 40 parts of northern Chinese caterpillar Fungus, 7 parts of oyster polypeptide powders, 2 parts of corn Gly-His-Lys, 15 parts, sheep kidney, donkey whip 7Part, 23 parts of mulberries, 11 parts of thes membrane of a chicken's gizzard, 6 parts of perilla leafs, 5 parts of lotus roots, 3 parts of hawthorn, 5 parts, cabbage, 20 parts, leek,11 parts of pollen pinis, 3 parts of the seeds of Job's tears, 7 parts, tomato, 11 parts of dandelions, 13 parts of roses, 0.2 part of ferrous fumarate, breast0.1 part, acid zinc, 0.3 part of yeast selenium, for subsequent use;
(2) the membrane of a chicken's gizzard, pollen pini, the seed of Job's tears are pulverized, crossed 200 mesh sieves, for subsequent use;
(3) sheep kidney, donkey whip and hawthorn are got 1 time by 8 times of water extractions, each 2 hours, filter the another device storage of filtrate;
(4) by filter residue in above-mentioned (3), add northern Chinese caterpillar Fungus, mulberries, perilla leaf, lotus root, cabbage, leek, tomato,Dandelion, rose, get 2 times by 12 times of water extractions, each 2 hours, filters the another device storage of filtrate;
(5) merge filtrate in above-mentioned (3) and (4), reduced pressure concentration, dry, the dried cream powder making is ground into 90 orders, for subsequent use;
(6) in above-mentioned (5), in dried cream powder, add material in above-mentioned (2), oyster polypeptide powder, corn Gly-His-Lys, ferrous fumarate,Zinc lactate, yeast selenium and proper auxiliary materials, dry method granulation, sieves, whole grain, packaging, inspection, warehouse-in, granulation agent.Toxicity test and pharmacodynamics correlation test situation are as follows:
1, acute toxicity test
Because this present composition prepared product toxicity is lower, be subject to reagent not measure LD50, do the maximum dosage-feeding test of ig.Before ig administration, mouse fasting be can't help water 12 hours, present composition prepared product is mixed with after Cmax to 30 mouse (♂♀ half and half) difference ig present composition prepared product (0.65ml10g-1), the response situation of observing immediately mouse after administration,And Continuous Observation 14 days, after administration, mouse obviously suppressed in 12 hours, but had no dead.
2, long term toxicity test
Rat gives the continuous gavage of present composition prepared product 24 weeks, observe the 12nd week, 24 weeks and drug withdrawal after 2 weeks (26Week) the toxic reaction situation of rat. Rat is divided into 4 groups at random: control group, present composition prepared product little, in, largeDosage group (be equivalent to quantity 25 times, 50 times, 100 times), ig administration, every day 2 times, continuous 24 weeks,When medication 12 weeks, 24 weeks and drug withdrawal recover 2 weeks, femoral artery bloodletting, execution animal, do index of correlation and detect. Result shows:With control group comparison, 12 weeks time, the heavy dose of group of present composition prepared product cruor time extending, TBIL and AST raise,CHOL reduces. 24 weeks time, present composition prepared product extract is little, in, heavy dose of group cruor time extending, little, in,Heavy dose of group TBIL raises, and small dose group AST raises, and middle dosage group GLU raises, and heavy dose of group CHOL reduces, in,Heavy dose of group ovary organ coefficient increases, and heavy dose of group uterus organ coefficient reduces. After drug withdrawal when 2 weeks (26 weeks), above fingerIt is normal that mark all recovers, only present composition prepared product little, in, heavy dose of group TBIL raises compared with control group, but and 24 weeks timeCompare and be remarkable reduction trend, middle dosage group ALT raises; Middle dosage group ovary organ coefficient slightly increases. Result demonstration, this24 weeks toxicity of the continuous ig administration of bright composition prepared product Three doses is humble, clinical use safety.
Its Pharmacodynamics result of study is as follows:
1, the impact on D-lactose aging model mouse skin moisture
Select the qualified female nude mouse of quarantine to be divided at random 6 groups, 9 every group: normal, model control group, vitamin EControl group, the high, medium and low dosage group of prepared product of the present invention (dosage be approximately equivalent to respectively people's clinical equivalent dosage 20,10,5 times). Except Normal group, all the other respectively organize the D-lactose 1000mg/kg of nude mice every morning hypodermic injection through filtration sterilization,Normal group nude mice hypodermic injection every day equivalent physiological saline, continuous 6 weeks. The modeling of each group starts to gavage corresponding medicine simultaneouslyMg/kg (normal group and model group gavage the distilled water of equivalent), every day 1 time, continuous 6 weeks. Survey weekly with moisture of skin analyzerFixed 1 moisture of skin. Result shows, prepared product group moisture of skin of the present invention obviously increases, and is conducive to improve moisture of skin.
The impact of table 1 on D-lactose aging model mouse skin moisture (x ± s)
With relatively * P < 0.05 of model group, * * P < 0.01
2, the impact on visual fatigue rat model
Get rat, heavily about 150g, male and female half and half, are divided into respectively 6 groups at random, 10 every group: normal, model control group,Lutein control group, (dosage is approximately equivalent to respectively people's clinical equivalent dosage to the high, medium and low dosage group of prepared product of the present invention20,10,5 times). Normal group is by body weight intramuscular injection sterilizing pharmaceutical grade vegetable oil; All the other 5 groups with progesterone in mouse back leg fleshMeat injection, dosage is 20mg/kg progesterone. Normal group disposable celiac injection citric acid solution, dosage is 6g/kg,All the other group disposable celiacs are injected 1% Streptozotocin solution, and dosage is 65mg/kg, then gives normal diet. Large after 3dCaudal vein blood sampling is surveyed blood sugar by Roche blood glucose meter, and blood sugar is the test group of including in more than 16.7mmol/L. Same after the modeling of each groupTime start to gavage corresponding medicine mg/kg (normal group and model group gavage the distilled water of equivalent), every day 1 time, continuous 30 days.Keep 12h illumination and 12h dark every day, the drinking-water of freely ingesting. After feeding 30d, put to death rat with dislocation method, extract eyeball,The complete crystalline lens of isolating, crystalline lens grinds with physiological saline ice bath, makes mass concentration and be 10% ice-cold homogenate, usesMDA in kit measurement crystalline lens (MDA), GSH (glutathione) content. Result shows, prepared product group of the present invention the third twoAldehyde reduces, and glutathione raises, and visual fatigue is had to mitigation.
The impact of the anti-visual fatigue rat model of table 3 (x ± s)
With relatively * P < 0.05 of model group, * * P < 0.01
3, the impact on chloasma model mice
Get the qualified female kunming mice of quarantine, be divided at random respectively 6 groups, 10 every group: normal, model control group, dimensionRaw plain C control group, (dosage is approximately equivalent to respectively people's clinical equivalent dosage to the high, medium and low dosage group of prepared product of the present invention20,10,5 times). Normal group is by body weight intramuscular injection sterilizing pharmaceutical grade vegetable oil; All the other 5 groups with progesterone in mouse back leg fleshMeat injection, dosage is 20mg/kg progesterone. Every morning, once two legs are injection alternately, continuous 30 days. Simultaneously animal every dayThe morning irradiation ultraviolet radiation 30 minutes. Modeling starts to gavage corresponding medicine 20mg/kg, continuous 30 days every afternoon simultaneously. EndAfter inferior administration, it measures antioxidative activities the skin that the ultraviolet ray of learning from else's experience is irradiated, and measures liver lipofuscin simultaneously. Result shows, basisInvention prepared product group antioxidative activities ability is strong, and liver lipofuscin is low, is conducive to eliminating chloasma.
The impact of table 3 on chloasma model mice (x ± s)
With relatively * P < 0.05 of model group, * * P < 0.01
4, the impact on normal male mice mating ability
Control sample 1: get Cordyceps sinensis appropriate, according to preparation method's preparation under the present invention, make suitable concentration, for subsequent use, contrastOrganize 1 test dose 32.8 (mg/kg);
Control sample 2: get northern Chinese caterpillar Fungus appropriate, according to preparation method's preparation under the present invention, make suitable concentration, for subsequent use, rightAccording to group 2 test doses 32.8 (mg/kg);
Control sample 3:(1) take by weight 40 parts of northern Chinese caterpillar Fungus, 7 parts of oyster polypeptide powders, 2 parts of corn Gly-His-Lys, sheep kidney 15Part, 7 parts of donkey whips, 23 parts of mulberries, 11 parts of thes membrane of a chicken's gizzard, 6 parts of perilla leafs, 5 parts of lotus roots, 3 parts of hawthorn, 5 parts, cabbage,20 parts, leek, 11 parts of pollen pinis, 3 parts of the seeds of Job's tears, 7 parts, tomato, 11 parts of dandelions, 13 parts of roses, fumaric acid Asia0.2 part of iron, 0.1 part of zinc lactate, 0.3 part of yeast selenium, for subsequent use;
(2) the membrane of a chicken's gizzard, pollen pini, the seed of Job's tears are pulverized, crossed 200 mesh sieves, for subsequent use;
(3) sheep kidney, donkey whip are got 2 times by 8 times of water extractions, each 2 hours, filtered the another device storage of filtrate;
(4) by filter residue in above-mentioned (3), add northern Chinese caterpillar Fungus, mulberries, perilla leaf, lotus root, cabbage, leek, tomato,Dandelion, rose, hawthorn, get 2 times by 12 times of water extractions, each 2 hours, filters the another device storage of filtrate;
(5) merge filtrate in above-mentioned (3) and (4), reduced pressure concentration, dry, the dried cream powder making is ground into 90 orders, for subsequent use;
(6) in above-mentioned (5), in dried cream powder, add material in above-mentioned (2), oyster polypeptide powder, corn Gly-His-Lys, ferrous fumarate,Zinc lactate, yeast selenium and proper auxiliary materials, dry method granulation, sieves, whole grain, packaging, inspection, warehouse-in, granulation agent,Make suitable concentration, for subsequent use, control group 3 test doses 32.8 (mg/kg).
Control sample 4: Liuwei Dihuang Wan, make suitable concentration, for subsequent use, control group 4 test doses 32.8 (mg/kg).
Get 80 of the about 20g male mices of body weight, weigh, be divided at random 8 groups, 10 every group: normal group, control group 1-4,The high, medium and low dosage group of prepared product of the present invention (dosage is approximately equivalent to respectively 20,10,5 times of people's clinical equivalent dosage).Each group starts to gavage corresponding medicine mg/kg (normal group gavages the distilled water of equivalent), every day 1 time, continuous 30 days simultaneously. Hand overJoin before experiment, prepare the adult female mouse of 80 about 40g of body weight, etherization, carries out bilateral ovaries enucleation, 2 weeksAfter test. Every female mouse hypodermic injection Estradiol Valerate 20g of 36h before experiment, 4h hypodermic injection progesterone 500g before experiment.When mating test, male mice is put into separately to cage, make its 5min that conforms, then put 1 female mouse of people, in administrationRear 1h starts to observe and records male mouse ejaculation frequency in male mouse's head time ejaculation time and 20min. Experimental result shows, the present inventionPrepared product group first pull-in time shortens, the time lengthening of ejaculating first, and in the unit interval, ejaculation frequency increases, and mating ability improves,Be conducive to improve sexual function.
The impact of table 4 on normal male mice mating ability (x ± s)
With relatively * P < 0.05 of model group, * * P < 0.01
5, the impact on reserpine induced mice depression model
Get the qualified female kunming mice of quarantine, be divided at random respectively 6 groups, 10 every group: normal group, distilled water group, chlorineImipramine control group, (dosage is approximately equivalent to respectively people's clinical equivalent dosage to the high, medium and low dosage group of prepared product of the present invention20,10,5 times). (normal group is not to anything, and distilled water group gavages after each component group, to start to gavage corresponding medicine mg/kgThe distilled water of equivalent), every day 1 time, continuous 7 days. After last administration 30min, except normal group, every mouse is pressed 2.5mg/kgLumbar injection reserpine, observes mouse ptosis situation, and accurate recording 1h palpebra interna sag and anus body temperature, observesThe situations such as spontaneous activity, ear tail color. Press Rubin grade scale, judge sag: 0 degree is for normally opening order; 1 degree is eyelidSagging 1/4; 2 degree are ptosis 1/2; 3 degree are ptosis 3/4; 4 degree are eyelid closure completely. Result shows, thisBright prepared product group ptosis degree obviously improves, and has antidepressant effect.
The impact of table 5 on reserpine induced mice depression model (x ± s)
With relatively * * P < 0.01 of model group
6, the impact on mouse prostatic hyperplasia model
60 of male mices getting body weight 18-22g, are divided into 6 groups at random, normal, model control group, prostatitis health control group,The high, medium and low dosage group of prepared product of the present invention (dosage is approximately equivalent to respectively 20,10,5 times of people's clinical equivalent dosage).After each component group, start to gavage corresponding medicine mg/kg (normal group is not to anything, and model group gavages the distilled water of equivalent),Except normal group, all the other mouse hypodermic injection every day testosterone propionate 5mg/kg body weight, after administration 30d, put to death 10 simultaneouslyMouse, cuts open inspection prostate. Result shows, prepared product group prostate weight in wet base of the present invention reduces, obviously before inhibition test mouseRow gland hyperplasia.
The impact of table 6 on mouse prostatic hyperplasia model (x ± s)
With relatively * P < 0.05 of model group, * * P < 0.01
The foregoing is only preferred embodiment of the present invention, not in order to limit the present invention, all in spirit of the present invention and formerAny amendment of doing, be equal to and replace and improvement etc., within all should being included in protection scope of the present invention.
Claims (4)
1. a cordyceps polypeptide composition, is characterized in that described composition is prepared from through extracting by the raw material of following weight portion:
10～45 parts of northern Chinese caterpillar Fungus, 5～15 parts of oyster polypeptide powders, 1～5 part of corn Gly-His-Lys, 12～43 parts, sheep kidney, 4～12 parts of donkey whips, 20～28 parts of mulberries, 5～19 parts of thes membrane of a chicken's gizzard, 2～10 parts of perilla leafs, 2～9 parts of lotus roots, 1～6 part of hawthorn, 1～8 part, cabbage, 13～28 parts, leek, 5～15 parts of pollen pinis, 1～5 part of the seed of Job's tears, 3～10 parts, tomato, 5～19 parts of dandelions, 9～20 parts of roses, 0.01～0.6 part of ferrous fumarate, 0.01～0.6 part of zinc lactate, 0.01～0.6 part of yeast selenium; Wherein, this extraction preparation method, carries out as follows:
(1) take by weight 10～45 parts of northern Chinese caterpillar Fungus, 5～15 parts of oyster polypeptide powders, 1～5 part of corn Gly-His-Lys, 12～43 parts, sheep kidney, 4～12 parts of donkey whips, 20～28 parts of mulberries, 5～19 parts of thes membrane of a chicken's gizzard, 2～10 parts of perilla leafs, 2～9 parts of lotus roots, 1～6 part of hawthorn, 1～8 part, cabbage, 13～28 parts, leek, 5～15 parts of pollen pinis, 1～5 part of the seed of Job's tears, 3～10 parts, tomato, 5～19 parts of dandelions, 9～20 parts of roses, 0.01～0.6 part of ferrous fumarate, 0.01～0.6 part of zinc lactate, 0.01～0.6 part of yeast selenium, for subsequent use;
(2) the membrane of a chicken's gizzard, pollen pini, the seed of Job's tears are pulverized, crossed 200 mesh sieves, for subsequent use;
(3) sheep kidney, donkey whip and hawthorn are got 1 time by 5～8 times of water extractions, each 2 hours, filter the another device storage of filtrate;
(4) will in filter residue in above-mentioned (3), add northern Chinese caterpillar Fungus, mulberries, perilla leaf, lotus root, cabbage, leek, tomato, dandelion, rose, get 2 times by 8～12 times of water extractions, each 1～3 hour, filter the another device storage of filtrate;
(5) merge filtrate in above-mentioned (3) and (4), reduced pressure concentration, dry, the dried cream powder making is ground into 80～100 orders, for subsequent use;
(6) in above-mentioned (5), in dried cream powder, add material, oyster polypeptide powder, corn Gly-His-Lys, ferrous fumarate, zinc lactate, yeast selenium and proper auxiliary materials in above-mentioned (2), make tablet, capsule, granule, oral liquid.
2. a kind of cordyceps polypeptide composition as claimed in claim 1, is characterized in that described composition is prepared from through extracting by the raw material of following weight portion:
14～40 parts of northern Chinese caterpillar Fungus, 7～12 parts of oyster polypeptide powders, 2～4 parts of corn Gly-His-Lys, 15～37 parts, sheep kidney, 7～10 parts of donkey whips, 23～26 parts of mulberries, 8～14 parts of thes membrane of a chicken's gizzard, 4～9 parts of perilla leafs, 3～7 parts of lotus roots, 2～4 parts of hawthorn, 3～7 parts, cabbage, 17～23 parts, leek, 8～13 parts of pollen pinis, 2～4 parts of the seeds of Job's tears, 6～9 parts, tomato, 7～15 parts of dandelions, 12～15 parts of roses, 0.08～0.4 part of ferrous fumarate, 0.05～0.3 part of zinc lactate, 0.06～0.5 part of yeast selenium.
3. as described in claim 1-2 any one, a kind of cordyceps polypeptide composition improves moisture of skin, alleviating asthenopia, functions of removing chloasma in preparation, improves the application in the health food of sexual function.
As described in claim 1-2 any one a kind of cordyceps polypeptide composition in the application of preparing in Cure of depression, hyperplasia of prostate medicine.
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| CN104172163B (en) * | 2014-08-12 | 2016-01-20 | 安徽阳光药业有限公司 | A kind of Cordyceps militaris micro mist health sheet and preparation method thereof |
| CN106943586A (en) * | 2017-03-31 | 2017-07-14 | 山东岐伯堂生物科技有限公司 | A kind of male health-care yang-invigorating formulation production method |
| KR102518581B1 (en) | 2017-11-29 | 2023-04-06 | (주)아모레퍼시픽 | Cosmetic composition containing the complex extract of brussels sprouts, lima bean and artichoke |
| CN108159389A (en) * | 2018-01-17 | 2018-06-15 | 江苏优曦特斯生物制品有限公司 | One kind is used to treat prostatitic Chinese medicine composition and preparation method thereof |
| CN108079277A (en) * | 2018-01-17 | 2018-05-29 | 江苏优曦特斯生物制品有限公司 | A kind of Chinese medicine composition for treating hyperplasia of prostate and preparation method thereof |
| CN108114266A (en) * | 2018-01-17 | 2018-06-05 | 江苏优曦特斯生物制品有限公司 | A kind of Chinese medicine composition for treating chronic prostatitis and preparation method thereof |
| CN108543056A (en) * | 2018-05-08 | 2018-09-18 | 徐州八百寿生物科技有限公司 | A kind of soybean peptide cordyceps sinensis cellulose product |
| CN108355128A (en) * | 2018-05-08 | 2018-08-03 | 徐州八百寿生物科技有限公司 | A kind of oyster peptide cordyceps sinensis cellulose product |
| CN109157570A (en) * | 2018-11-29 | 2019-01-08 | 江西济民可信金水宝制药有限公司 | A kind of complex capsule |
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| CN1724682A (en) * | 2005-07-11 | 2006-01-25 | 钱卫文 | Cordyceps polypeptide product and its preparation method and application |
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