CN109157570A - A kind of complex capsule - Google Patents
A kind of complex capsule Download PDFInfo
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- CN109157570A CN109157570A CN201811440165.5A CN201811440165A CN109157570A CN 109157570 A CN109157570 A CN 109157570A CN 201811440165 A CN201811440165 A CN 201811440165A CN 109157570 A CN109157570 A CN 109157570A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
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- A61K36/066—Clavicipitaceae
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
- A61K36/725—Ziziphus, e.g. jujube
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- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
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Abstract
The invention belongs to pharmaceutical technology fields, provide a kind of compound paecilomyces hepiall chen, prepare capsule 's content with the raw material of following parts by weight: 20-30 parts of Paecilomyces hepiali chen Cs-4 cordyceps, 15-30 parts of jujube, 10-20 parts of papaya powder, 3-6 parts of lotus root starch, 1-2 parts of cornstarch, 10-20 parts of ethyl alcohol and water；Then each raw material is gradually uniformly mixed, prepares corn starch liquid the preparation method comprises the following steps: first crush jujube to obtain red date powder by content; then with itself and ethyl alcohol together as adhesive, the spray-dried granulator pelleting of mixed material obtained, whole grain, total mix; it is encapsulated, obtain product.Formula is scientific and reasonable for this product, good to the improvement of chloasma, and rapid-action, dosage is small.In addition, the preparation method of this product is easy to operate, is easy to control, it is at low cost.
Description
Technical field
The invention belongs to pharmaceutical technology fields more particularly to a kind of compound paecilomyces hepiall chen and its preparation method and application.
Background technique
The effective component of Jinshuibao is fermentation cordyceps, specially Paecilomyces hepiali chen Cs-4 bacterium powder.The quasi- blueness of bat moth
Mould powder is isolated Cordyceps Militaris --- bat from fresh aweto (cordyceps sinensis (Berk) sacc)
Bat moth Paecilomyces varioti (Paecilomyces hepiali Chen&Dai) is made through liquid deep layer fermenting culture, filtering, drying, crushing
At product.
Peacilomyce hepiahi bacterium kind is Jiangxi Guoyao Co., Ltd and institute of Materia Medica,Chinese Academy of Medical Sciences health
Natural drug biosynthesis key lab of portion produces from Qinghai by 10 years and isolates and purifies and obtain in natural cordyceps, should
The fermentation cordyceps of strain production from the acquisitions Ministry of Public Health in 1989 are approved as a kind of bulk pharmaceutical chemicals new drug, and (code: it is quasi- that (89) defend medicine
Word Z-17), in the clinical application of more than ten years, good clinical effectiveness and reliable safety obtain domestic and international doctor deeply
The approval of medicine experts and scholars.
Paecilomyces hepiali chen Cs-4 bacterium powder has anti-inflammatory, cough-relieving, eliminating the phlegm, calmness, promotees sexual gland effect；It is solid that serum gallbladder can be reduced
Alcohol, triglyceride and lipid peroxide increase the blood supply of cardiac muscle with brain, have slight blood pressure lowering, inhibit platelet aggregation, prolong
When long anoxic the effects of survival time of animals, there is protective effect to heart and brain tissues；It can relieve fatigue simultaneously.
Modern life rhythm is fast, and operating pressure is big, causes the lives such as diet work and rest irregular, most people is in inferior health
The stress of state, especially women is big, it may appear that a series of skin problem.Cs-4 bacterium powder is relieved fatigue with certain,
Improve the effect of skin quality, but existing Jinshuibao product is not directed to skin problem, also without the related data of improvement skin quality.
The effect of Jinshuibao, obtains everybody generally approval, develops one kind specifically for skin problem, can play effects of beautification and nourishing face
Compound paecilomyces hepiall chen, accord with the demands of the market.
Summary of the invention
The purpose of the present invention is to provide a kind of compound paecilomyces hepiall chen, which not only contains Paecilomyces hepiali chen Cs-4
Cordyceps, the also jujube containing integration of drinking and medicinal herbs, papaya powder, lotus root starch and cornstarch, it is good to the improvement of skin, it is especially right
It is good in the effect of chloasma.In addition, reducing cost invention also improves the preparation method of capsule, simplify operation；Production obtained
Quality is good.
Specifically, in view of the deficiencies of the prior art, the present invention provides the following technical scheme that
A kind of compound paecilomyces hepiall chen prepares the raw material of capsule 's content in parts by weight are as follows: Paecilomyces hepiali chen Cs-4
20-30 parts of cordyceps, 15-30 parts of jujube, 10-20 parts of papaya powder, 3-6 parts of lotus root starch, 1-2 parts of cornstarch, 10-20 parts of ethyl alcohol
And water.
Preferably, compound paecilomyces hepiall chen is made by following preparation step:
S1. the jujube of recipe quantity is taken, is crushed, is sieved with 100 mesh sieve, obtain red date powder；
S2. the Paecilomyces hepiali chen Cs-4 cordyceps of recipe quantity are mixed with papaya powder, sieve with 100 mesh sieve net, it is impossible to
It is crushed by the particle of 100 mesh screens, is sieved again, red date powder is added in the powder of merga pass sieve, is uniformly mixed
Afterwards, mixed powder A is obtained；
S3. the lotus root starch and half cornstarch of recipe quantity half are taken, mixes, sieves with 100 mesh sieve net, it is impossible to pass through 100 mesh
The particle of sieve is crushed, and is sieved again, the powder of merga pass sieve, and mixed powder A is added and is mixed after mixing
Close powder B；Then remaining half lotus root starch is added, is uniformly mixed, obtains mixed powder C；
S4. remaining half cornstarch is taken, adds water, prepares corn starch liquid；
S5. mixed powder C, corn starch liquid and ethyl alcohol are uniformly mixed, obtain mixed material；
S6. mixed material is poured into spray-drying pelleting machine, is pelletized, whole grain, total mix obtains capsule 's content, then
Capsule filling is carried out, compound paecilomyces hepiall chen finished product is prepared.
Preferably, jujube is crushed in step S1 using the method for separating twice, is crushed, is obtained using boulder crusher first
Then coarse powder is put into micronizer and is crushed by coarse powder.
Preferably, the partial size of coarse powder is in 1-10mm.
Preferably, in step S4 corn starch liquid the preparation method comprises the following steps: first into cornstarch addition 2-4 parts by weight water,
Stir 20-40min, then be added 3-4 parts by weight boiling water, be placed in 80 DEG C of water-baths and heat, continue stir 30-40min to get.
Preferably, preparing the revolving speed stirred during corn starch liquid is 150-200r/min.
Preferably, in step S5 mixed material the preparation method comprises the following steps: take the mixed powder C of 30% weight, 30% weight is added
Corn starch liquid and recipe quantity half ethyl alcohol, with 120r/min stir 20min, be added 30% weight mixed powder C, stirring
Under the conditions of the corn starch liquid of 40% weight is added, continue to stir 30min, add the mixed powder C of 40% weight, stirring condition
The lower corn starch liquid and the other half ethyl alcohol that 30% weight is added, continues to stir 30-40min, obtains uniform mixed material.
Preferably, the operating temperature of spray-drying pelleting machine is 45-65 DEG C in step S6.
Preferably, the mass concentration of ethyl alcohol is 75%；The particle moisture content that spray-drying pelleting machine is prepared in step S6
In 0.3-0.5%；Whole grain is using 65 mesh screens.
Preferably, the specification of compound paecilomyces hepiall chen is 0.33g/.
Compared with prior art, it effect of the invention and has an advantage that:
1. compound paecilomyces hepiall chen provided by the invention not only contains Paecilomyces hepiali chen Cs-4 cordyceps, also contain medicine
Homologous jujube, papaya powder, lotus root starch and cornstarch are eaten, formula is scientific and reasonable, and it is good to the improvement of skin, particularly with Huang
The effect of foxiness is good.This product is rapid-action, and dosage is small, is administered one day once, and 2 tablets each time, continuously take can produce obviously for one week
Effect.
2. in the content of compound paecilomyces hepiall chen provided by the invention, active constituent content is high, each component interaction,
The improvement result to skin is remarkably reinforced.
3. the present invention mixes each raw material component by the way of gradually mixing, the mixed powder of uniform and smooth, corn are obtained
Starch can promote to be disintegrated, rapid-action；Corn starch liquid and ethyl alcohol play the role of adhesive, and the mixed material being prepared is glutinous
Degree and hardness are moderate, are conducive to pelletize, and the particle rounding being prepared is uniform, partial size difference is small；After filling capsule, take orally
Bioavilability is high, and the effect for improving skin problem is good.
To sum up, present invention optimizes the composition of capsule 's content and proportion and preparation conditions, are matched by scientific and reasonable
Side, standardization and manageable technique, the compound paecilomyces hepiall chen being prepared are disintegrated fast, good absorbing, and effect is prominent, to face
Chloasma has extraordinary improvement.
Specific embodiment
The present invention provides a kind of compound paecilomyces hepiall chen, capsule 's content prepares raw material are as follows: Paecilomyces hepiali chen Cs-
4 cordyceps 20-30 parts by weight, jujube 15-30 parts by weight, papaya powder 10-20 parts by weight, lotus root starch 3-6 parts by weight, corn form sediment
Powder 1-2 parts by weight, 75% ethyl alcohol 10-20 parts by weight of mass concentration and water.
The preparation step of compound paecilomyces hepiall chen of the present invention includes:
S1. the jujube of recipe quantity is taken, is crushed, is sieved with 100 mesh sieve, obtain red date powder.Jujube is crushed using separating twice
Method, crushed first using boulder crusher, obtain partial size in the coarse powder of 1-10mm, coarse powder is then put into powder in micronizer
It is broken, obtain red date powder.
S2. the Paecilomyces hepiali chen Cs-4 cordyceps of recipe quantity are mixed with papaya powder, sieve with 100 mesh sieve net, it is impossible to
It is crushed by the particle of 100 mesh screens, is sieved again, red date powder is added in the powder of merga pass sieve, is uniformly mixed
Afterwards, mixed powder A is obtained.
S3. the lotus root starch and half cornstarch of recipe quantity half are taken, mixes, sieves with 100 mesh sieve net, it is impossible to pass through 100 mesh
The particle of sieve is crushed, and is sieved again, the powder of merga pass sieve, and mixed powder A is added and is mixed after mixing
Close powder B；Then remaining half lotus root starch is added, is uniformly mixed, obtains mixed powder C.
S4. remaining half cornstarch is taken, adds water, prepares corn starch liquid；Specifically the preparation method comprises the following steps: first forming sediment toward corn
2-4 parts by weight water is added in powder, 20-40min is stirred with the revolving speed of 150-200r/min, 3-4 parts by weight boiling water is then added, sets
Heated in 80 DEG C of water-baths, continue stir 30-40min to get.
S5. mixed powder C, corn starch liquid and ethyl alcohol are uniformly mixed, obtain mixed material；Mixed material it is specific
The preparation method comprises the following steps: taking the mixed powder C of 30% weight, the corn starch liquid of 30% weight and the ethyl alcohol of recipe quantity half is added, with
120r/min stirs 20min, and the mixed powder C of 30% weight is added, the corn starch liquid of 40% weight is added under stirring condition, after
Continuous stirring 30min, adds the mixed powder C of 40% weight, and the corn starch liquid of 30% weight and another is added under stirring condition
Half ethyl alcohol continues to stir 30-40min, obtains uniform mixed material.The hardness of the mixed material is moderate, is conducive to granulation.
S6. mixed material is poured into spray-drying pelleting machine, is pelletized, the operating temperature of spray-drying pelleting machine is 45-
65 DEG C, particle moisture content obtained is in 0.3-0.5%, and using 65 mesh screen whole grains, total mix obtains capsule 's content, then carries out
Capsule filling, is prepared compound paecilomyces hepiall chen finished product.The specification of the compound paecilomyces hepiall chen is 0.33g/.
The present invention is further described with specific embodiment below.
Material involved in the present invention, reagent and equipment are commercially available；Wherein, Cs-4 cordyceps sinensis bacterium powder raw material is Jiangxi traditional Chinese medicines
Limited liability company's production, bulk pharmaceutical chemicals national drug standard number are Z10899021.In addition,
Lotus root starch is purchased from Xinghua City Tian Nong fruit-vegetable food Co., Ltd；
Boulder crusher (WF-400) is purchased from Jiangyin City Xin An powder equipment Co., Ltd；
Micronizer (WFJ-20) is purchased from Jiangyin City Xin An powder equipment Co., Ltd；
Spray-drying pelleting machine (PGL-20B) is purchased from Changzhou Suncheer Drying Equipment Co., Ltd..
Embodiment 1
The raw material for preparing of a kind of compound paecilomyces hepiall chen, capsule 's content includes: Paecilomyces hepiali chen Cs-4 cordyceps
20 parts by weight, 15 parts by weight of jujube, 10 parts by weight of papaya powder, 3 parts by weight of lotus root starch, 1 parts by weight of cornstarch, mass concentration 75%
10 parts by weight of ethyl alcohol and water.
The preparation step of compound paecilomyces hepiall chen includes:
S1. the jujube of recipe quantity is taken, separating twice is carried out, is crushed first using boulder crusher, obtains partial size 1-4mm's
Then coarse powder is put into micronizer and is crushed, sieved with 100 mesh sieve, obtain red date powder by coarse powder.
S2. the Paecilomyces hepiali chen Cs-4 cordyceps of recipe quantity are mixed with papaya powder, sieve with 100 mesh sieve net, it is impossible to
It is crushed by the particle of 100 mesh screens with micronizer, is sieved again, jujube is added in the powder of merga pass sieve
Powder obtains mixed powder A after mixing.
S3. the lotus root starch and half cornstarch of recipe quantity half are taken, mixes, sieves with 100 mesh sieve net, it is impossible to pass through 100 mesh
The particle of sieve is crushed with micronizer, is sieved again, the powder of merga pass sieve, and mixed powder A is added, and mixing is equal
After even, mixed powder B is obtained；Then remaining half lotus root starch (sieving with 100 mesh sieve net) is added, is uniformly mixed, obtains mixed powder C.
S4. remaining half cornstarch is taken, adds water, prepares corn starch liquid；Specifically the preparation method comprises the following steps: first forming sediment toward corn
2 parts by weight water are added in powder, 40min is stirred with the revolving speed of 150r/min, 3 parts by weight boiling water are then added, are placed in 80 DEG C of water-baths
Middle heating, continue stir 30min to get.
S5. mixed powder C, corn starch liquid and ethyl alcohol are uniformly mixed, obtain mixed material；Mixed material it is specific
The preparation method comprises the following steps: taking 30% mixed powder C, 30% corn starch liquid and the ethyl alcohol of recipe quantity half is added, is stirred with 120r/min
20min is mixed, 30% mixed powder C is added, 40% corn starch liquid is added under stirring condition, continues to stir 30min, adds 40%
30% corn starch liquid and the other half ethyl alcohol is added under stirring condition in mixed powder C, continues to stir 30min, uniformly be mixed
Material.The hardness of the mixed material is moderate, is conducive to granulation.
S6. mixed material is poured into spray-drying pelleting machine, is pelletized, the operating temperature of spray-drying pelleting machine is 45
DEG C, particle moisture content obtained is 0.5%, and using 65 mesh screen whole grains, total mix obtains capsule 's content, then carries out capsule and fills out
It fills, compound paecilomyces hepiall chen finished product is prepared.The specification of compound paecilomyces hepiall chen is 0.33g/.
Embodiment 2
The raw material for preparing of a kind of compound paecilomyces hepiall chen, capsule 's content includes: Paecilomyces hepiali chen Cs-4 cordyceps
25 parts by weight, 20 parts by weight of jujube, 15 parts by weight of papaya powder, 4 parts by weight of lotus root starch, 1 parts by weight of cornstarch, mass concentration 75%
15 parts by weight of ethyl alcohol and water.
The preparation step of compound paecilomyces hepiall chen includes:
S1. the jujube of recipe quantity is taken, separating twice is carried out, is crushed first using boulder crusher, obtains partial size in the thick of 3-5mm
Then coarse powder is put into micronizer and is crushed, sieved with 100 mesh sieve, obtain red date powder by powder.
S2. the Paecilomyces hepiali chen Cs-4 cordyceps of recipe quantity are mixed with papaya powder, sieve with 100 mesh sieve net, it is impossible to
It is crushed by the particle of 100 mesh screens with micronizer, is sieved again, jujube is added in the powder of merga pass sieve
Powder obtains mixed powder A after mixing.
S3. the lotus root starch and half cornstarch of recipe quantity half are taken, mixes, sieves with 100 mesh sieve net, it is impossible to pass through 100 mesh
The particle of sieve is crushed with micronizer, is sieved again, the powder of merga pass sieve, and mixed powder A is added, and mixing is equal
After even, mixed powder B is obtained；Then remaining half lotus root starch (sieving with 100 mesh sieve net) is added, is uniformly mixed, obtains mixed powder C.
S4. remaining half cornstarch is taken, adds water, prepares corn starch liquid；Specifically the preparation method comprises the following steps: first forming sediment toward corn
3 parts by weight water are added in powder, 30min is stirred with the revolving speed of 170r/min, 4 parts by weight boiling water are then added, are placed in 80 DEG C of water-baths
Middle heating, continue stir 35min to get.
S5. mixed powder C, corn starch liquid and ethyl alcohol are uniformly mixed, obtain mixed material；Mixed material it is specific
The preparation method comprises the following steps: taking 30% mixed powder C, 30% corn starch liquid and the ethyl alcohol of recipe quantity half is added, is stirred with 120r/min
20min is mixed, 30% mixed powder C is added, 40% corn starch liquid is added under stirring condition, continues to stir 30min, adds 40%
30% corn starch liquid and the other half ethyl alcohol is added under stirring condition in mixed powder C, continues to stir 35min, uniformly be mixed
Material.The hardness of the mixed material is moderate, is conducive to granulation.
S6. mixed material is poured into spray-drying pelleting machine, is pelletized, the operating temperature of spray-drying pelleting machine is 55
DEG C, particle moisture content obtained is 0.4%, and using 65 mesh screen whole grains, total mix obtains capsule 's content, then carries out capsule and fills out
It fills, compound paecilomyces hepiall chen finished product is prepared.The specification of compound paecilomyces hepiall chen is 0.33g/.
Embodiment 3
The raw material for preparing of a kind of compound paecilomyces hepiall chen, capsule 's content includes: Paecilomyces hepiali chen Cs-4 cordyceps
30 parts by weight, 30 parts by weight of jujube, 20 parts by weight of papaya powder, 6 parts by weight of lotus root starch, 2 parts by weight of cornstarch, mass concentration 75%
20 parts by weight of ethyl alcohol and water.
The preparation step of compound paecilomyces hepiall chen includes:
S1. the jujube of recipe quantity is taken, separating twice is carried out, is crushed first using boulder crusher, obtains partial size 6-10mm's
Then coarse powder is put into micronizer and is crushed, sieved with 100 mesh sieve, obtain red date powder by coarse powder.
S2. the Paecilomyces hepiali chen Cs-4 cordyceps of recipe quantity are mixed with papaya powder, sieve with 100 mesh sieve net, it is impossible to
It is crushed by the particle of 100 mesh screens with micronizer, is sieved again, jujube is added in the powder of merga pass sieve
Powder obtains mixed powder A after mixing.
S3. the lotus root starch and half cornstarch of recipe quantity half are taken, mixes, sieves with 100 mesh sieve net, it is impossible to pass through 100 mesh
The particle of sieve is crushed with micronizer, is sieved again, the powder of merga pass sieve, and mixed powder A is added, and mixing is equal
After even, mixed powder B is obtained；Then remaining half lotus root starch (sieving with 100 mesh sieve net) is added, is uniformly mixed, obtains mixed powder C.
S4. remaining half cornstarch is taken, adds water, prepares corn starch liquid；Specifically the preparation method comprises the following steps: first forming sediment toward corn
4 parts by weight water are added in powder, 20min is stirred with the revolving speed of 200r/min, 4 parts by weight boiling water are then added, are placed in 80 DEG C of water-baths
Middle heating, continue stir 40min to get.
S5. mixed powder C, corn starch liquid and ethyl alcohol are uniformly mixed, obtain mixed material；Mixed material it is specific
The preparation method comprises the following steps: taking 30% mixed powder C, 30% corn starch liquid and the ethyl alcohol of recipe quantity half is added, is stirred with 120r/min
20min is mixed, 30% mixed powder C is added, 40% corn starch liquid is added under stirring condition, continues to stir 30min, adds 40%
30% corn starch liquid and the other half ethyl alcohol is added under stirring condition in mixed powder C, continues to stir 40min, uniformly be mixed
Material.The hardness of the mixed material is moderate, is conducive to granulation.
S6. mixed material is poured into spray-drying pelleting machine, is pelletized, the operating temperature of spray-drying pelleting machine is 65
DEG C, particle moisture content obtained is 0.3%, and using 65 mesh screen whole grains, total mix obtains capsule 's content, then carries out capsule and fills out
It fills, compound paecilomyces hepiall chen finished product is prepared.The specification of compound paecilomyces hepiall chen is 0.33g/.
Embodiment 4
The raw material for preparing of a kind of compound paecilomyces hepiall chen, capsule 's content includes: Paecilomyces hepiali chen Cs-4 cordyceps
20 parts by weight, 20 parts by weight of jujube, 12 parts by weight of papaya powder, 4 parts by weight of lotus root starch, 1.5 parts by weight of cornstarch, mass concentration
75% ethyl alcohol, 15 parts by weight and water.
The preparation step of compound paecilomyces hepiall chen is the difference from embodiment 1 is that step S4, the preparation side of corn starch liquid
Method are as follows: 3 parts by weight water are first added into cornstarch, 30min is stirred with the revolving speed of 180r/min, the boiling of 3 parts by weight is then added
Water is placed in 80 DEG C of water-baths and heats, continue stir 30min to get.
Remaining is the same as embodiment 1.
Embodiment 5
The raw material for preparing of a kind of compound paecilomyces hepiall chen, capsule 's content includes: Paecilomyces hepiali chen Cs-4 cordyceps
30 parts by weight, 20 parts by weight of jujube, 18 parts by weight of papaya powder, 3 parts by weight of lotus root starch, 2 parts by weight of cornstarch, mass concentration 75%
20 parts by weight of ethyl alcohol and water.
The preparation step of compound paecilomyces hepiall chen is same as Example 2.
Comparative example 1
A kind of paecilomyces hepiall chen, capsule 's content are Paecilomyces hepiali chen Cs-4 cordyceps, which can lead to
Sieve with 100 mesh sieve net.The specification of the capsule is 0.33g/.
Comparative example 2
The raw material for preparing of a kind of capsule, capsule 's content is 20 parts by weight of jujube, 15 parts by weight of papaya powder, 4 weight of lotus root starch
Part, 1 parts by weight of cornstarch, 75% ethyl alcohol of mass concentration, 15 parts by weight and water.The preparation step of the capsule and the area of embodiment 2
It is not only that, does not add Paecilomyces hepiali chen Cs-4 cordyceps in preparation process.
Comparative example 3
The raw material for preparing of a kind of compound paecilomyces hepiall chen, capsule 's content includes: Paecilomyces hepiali chen Cs-4 cordyceps
25 parts by weight, 20 parts by weight of jujube, 15 parts by weight of papaya powder, 4 parts by weight of lotus root starch, 1 parts by weight of cornstarch, mass concentration 75%
15 parts by weight of ethyl alcohol and water.
The preparation step of compound paecilomyces hepiall chen includes:
(1) jujube of recipe quantity is taken, separating twice is carried out, is crushed first using boulder crusher, obtains partial size in the thick of 3-5mm
Then coarse powder is put into micronizer and is crushed, sieved with 100 mesh sieve, obtain red date powder by powder.
(2) by the cornstarch of the Paecilomyces hepiali chen Cs-4 cordyceps of recipe quantity, papaya powder, lotus root starch and half
Mixing, sieves with 100 mesh sieve, cannot be crushed by the particle of 100 mesh screens with micronizer, be sieved again, merga pass
The powder of sieve, obtains mixed powder.
(3) corn starch liquid is prepared using the identical method of step S4 in embodiment 2.
(4) it prepares mixed material: taking 30% mixed powder, 30% corn starch liquid and the second of recipe quantity half is added
Alcohol stirs 20min with 120r/min, and 30% mixed powder is added, 40% corn starch liquid is added under stirring condition, continues to stir
30min adds 40% mixed powder, 30% corn starch liquid and the other half ethyl alcohol is added under stirring condition, continues to stir
35min obtains mixed material.
(5) compound paecilomyces hepiall chen, capule size 0.33g/ are prepared using the identical method of step S6 in embodiment 2
Grain.
Comparative example 4
This comparative example the difference from embodiment 1 is that, prepare in the raw material of capsule 's content without containing ethyl alcohol, i.e. step S5
It prepares mixed material and corn starch liquid is only added in the process, do not add ethyl alcohol.As a result, the mixed material viscosity mistake being prepared
Greatly, it is gathered into agglomerate, hence it is evident that see that distribution of color is uneven, which can not prepare uniform particle, illustrate this law not
Properly.
Comparative example 5
This comparative example the difference from embodiment 1 is that step S5, mixed material the preparation method comprises the following steps: by mixed powder C, corn
Starch slurry and ethyl alcohol disposably mix, and obtain mixed material.
Remaining is the same as embodiment 1.
Comparative example 6
The raw material for preparing of a kind of compound paecilomyces hepiall chen, capsule 's content includes: Paecilomyces hepiali chen Cs-4 cordyceps
30 parts by weight, 30 parts by weight of jujube, 20 parts by weight of papaya powder, 6 parts by weight of lotus root starch, 2 parts by weight of crospovidone, mass concentration
75% ethyl alcohol, 20 parts by weight and water.
The preparation step of compound paecilomyces hepiall chen includes:
Step S1 and S2 is same as Example 3.
Step S3. takes recipe quantity lotus root starch, sieves with 100 mesh sieve, it is impossible to by the particle micronizers of 100 mesh screens into
Row crushes, and is sieved again, the powder of merga pass sieve, and mixed powder A is added and obtains mixed powder B after mixing.
Step S4. takes the crospovidone of recipe quantity, and 6 parts by weight water are added, and prepares crospovidone solution.
Step S5. mixes mixed powder B, crospovidone solution and ethyl alcohol, and mixed material is made.
Step S6. is identical as the S6 in embodiment 3.
Test case 1
According to the Jinshuibao of disintegration time limit test as defined in Pharmacopoeia of People's Republic of China (general rule 0921) measurement preparation
The disintegration time limited of capsule, it the results are shown in Table 1.
| Disintegration time (min) | |
| Embodiment 1 | 12 |
| Embodiment 2 | 10 |
| Embodiment 3 | 14 |
| Embodiment 4 | 13 |
| Embodiment 5 | 12 |
| Comparative example 1 | 26 |
| Comparative example 2 | 19 |
| Comparative example 3 | 23 |
| Comparative example 4 | Mixed material is unqualified, does not detect |
| Comparative example 5 | 28 |
| Comparative example 6 | 17 |
Table 1.
From the data of table 1 it is obvious that the disintegration time of the compound paecilomyces hepiall chen of each embodiment preparation is than comparison
Example 1 (capsule 's content is only Cs-4 bacterium powder), comparative example 2 (capsule 's content is free of Cs-4 bacterium powder), (raw material is primary for comparative example 3
Property mixing), comparative example 5 (in mixed material preparation process, mixed powder is disposably mixed with corn starch liquid, ethyl alcohol) and comparative example
6 (crospovidone being added in capsule 's content, be free of cornstarch) will be shorter, illustrates composition and the preparation of capsule 's content
Technique will affect the disintegration time of product, and then influence onset time.Gold prepared by comparative example 1, comparative example 3 and comparative example 5
The disintegration time of water health-care capsule is more than 20 minutes, and longer than embodiment much curative effect will be more worse than embodiment, so without must
It is further studied.
Test case 2
Observe compound paecilomyces hepiall chen the facing for chloasma faciei of embodiment 1-3 and comparative example 2, the preparation of comparative example 6
Bed improvement, specific test method are as follows:
(1) it is included in standard
It is the crowd of chloasma by clinical diagnosis, can becomes subject.
(2) instructions of taking
Once a day, 2 tablets each time.
(3) it scores
It before medication, takes a picture to subject within the 7th day and 14 days after medication, using same exposure ginseng when photograph
Then number uses angel's pigment analysis software, sets identical tolerance, measure analysis to patient's color spot.Compare each
The average gray and color spot area that time point analysis obtains, it is grey before therapeutic index=(gray scale before gray scale-medication after medication)/medication
Degree × 100%.
Recovery from illness: therapeutic index >=90%；
Effective: therapeutic index is in 60-89%；
Improve: therapeutic index is in 20-59%；
It is invalid: therapeutic index ﹤ 20%.
(4) statistical disposition
Treatment is compared to 400 selected subjects, is divided into 5 groups at random, every group of 80 people.According to medication above-mentioned
Method carries out medication, is checked at medication the 7th day and the 14th day, and efficacy result statistics is shown in Table 2 and 3.
| Number | Recovery from illness | It is effective | Improve | In vain | Total effective rate (%) | |
| Embodiment 1 | 80 | 24 | 29 | 20 | 7 | 91.25 |
| Embodiment 2 | 80 | 28 | 26 | 22 | 4 | 95.0 |
| Embodiment 3 | 80 | 25 | 31 | 19 | 5 | 93.75 |
| Comparative example 2 | 80 | 9 | 18 | 24 | 29 | 63.75 |
| Comparative example 6 | 80 | 12 | 23 | 27 | 18 | 77.5 |
The 7th day efficacy result of table 2.
| Number | Recovery from illness | It is effective | Improve | In vain | Total effective rate (%) | |
| Embodiment 1 | 80 | 29 | 35 | 14 | 2 | 97.5 |
| Embodiment 2 | 80 | 32 | 36 | 11 | 1 | 98.75 |
| Embodiment 3 | 80 | 30 | 38 | 10 | 2 | 97.5 |
| Comparative example 2 | 80 | 12 | 22 | 29 | 17 | 78.75 |
| Comparative example 6 | 80 | 15 | 27 | 23 | 15 | 81.25 |
The 14th day efficacy result of table 3.
It can see from the data of table 2 and table 3, improvement of the compound paecilomyces hepiall chen of embodiment 1-3 preparation to chloasma
Effect is very good, and after continuous use 7 days, after effective percentage is above 90%, continuous use 14 days, effective percentage is more than 95%；And it is right
Paecilomyces hepiall chen prepared by ratio 2 and comparative example 6 is efficient to be still not up to 82% after continuously taking 14 days, is far below and implements
Example.In addition, not only chloasma is improved, whole skin shape after subject takes the compound paecilomyces hepiall chen of embodiment preparation
Condition is also improved, and complexion is more preferable.Therefore, provided by the invention to be made of special, and be prepared by specific process compound
Paecilomyces hepiall chen has unique effect for the improvement of chloasma.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
In the technical scope disclosed by the present invention, any changes or substitutions that can be easily thought of by anyone skilled in the art,
It should be covered by the protection scope of the present invention.
Claims (10)
1. a kind of compound paecilomyces hepiall chen, which is characterized in that in parts by weight, prepare the raw material of capsule 's content are as follows: bat moth
20-30 parts of Paecilomyces varioti Cs-4 cordyceps, 15-30 parts of jujube, 10-20 parts of papaya powder, 3-6 parts of lotus root starch, 1-2 parts of cornstarch,
10-20 parts of ethyl alcohol and water.
2. compound paecilomyces hepiall chen according to claim 1, which is characterized in that be made by following preparation step:
S1. the jujube of recipe quantity is taken, is crushed, is sieved with 100 mesh sieve, obtain red date powder；
S2. the Paecilomyces hepiali chen Cs-4 cordyceps of recipe quantity are mixed with papaya powder, sieves with 100 mesh sieve net, it is impossible to pass through
The particle of 100 mesh screens is crushed, and is sieved again, the powder of merga pass sieve, and red date powder is added and obtains after mixing
To mixed powder A；
S3. the lotus root starch and half cornstarch of recipe quantity half are taken, mixes, sieves with 100 mesh sieve net, it is impossible to pass through 100 mesh screens
Particle crushed, be sieved again, the powder of merga pass sieve, be added mixed powder A obtain mixed powder after mixing
B；Then remaining half lotus root starch is added, is uniformly mixed, obtains mixed powder C；
S4. remaining half cornstarch is taken, adds water, prepares corn starch liquid；
S5. mixed powder C, corn starch liquid and ethyl alcohol are uniformly mixed, obtain mixed material；
S6. mixed material is poured into spray-drying pelleting machine, is pelletized, whole grain, total mix obtains capsule 's content, then carries out
Capsule filling, is prepared compound paecilomyces hepiall chen finished product.
3. compound paecilomyces hepiall chen according to claim 2, which is characterized in that crush jujube in step S1 using two
The method of secondary crushing is crushed using boulder crusher first, obtains coarse powder, is then put into micronizer coarse powder and is crushed.
4. compound paecilomyces hepiall chen according to claim 3, which is characterized in that the partial size of coarse powder is in 1-10mm.
5. compound paecilomyces hepiall chen according to claim 2, which is characterized in that the preparation side of corn starch liquid in step S4
Method are as follows: 2-4 parts by weight water is first added into cornstarch, stirs 20-40min, 3-4 parts by weight boiling water is then added, is placed in 80
Heated in DEG C water-bath, continue to stir 30-40min to get.
6. compound paecilomyces hepiall chen according to claim 5, which is characterized in that revolving speed when stirring is 150-200r/
min。
7. according to the described in any item compound paecilomyces hepiall chens of claim 2-6, which is characterized in that mixed material in step S5
The preparation method comprises the following steps: taking the mixed powder C of 30% weight, the corn starch liquid of 30% weight and the ethyl alcohol of recipe quantity half is added, with
120r/min stirs 20min, and the mixed powder C of 30% weight is added, the corn starch liquid of 40% weight is added under stirring condition, after
Continuous stirring 30min, adds the mixed powder C of 40% weight, and the corn starch liquid of 30% weight and another is added under stirring condition
Half ethyl alcohol continues to stir 30-40min, obtains uniform mixed material.
8. compound paecilomyces hepiall chen according to claim 7, which is characterized in that the work of spray-drying pelleting machine in step S6
Making temperature is 45-65 DEG C.
9. compound paecilomyces hepiall chen according to claim 8, which is characterized in that the mass concentration of ethyl alcohol is 75%；Step
The pellet moisture that spray-drying pelleting machine is prepared in S6 is in 0.3-0.5%, and whole grain is using 65 mesh screens.
10. compound paecilomyces hepiall chen according to claim 9, which is characterized in that the specification of the compound paecilomyces hepiall chen
It is 0.33g/.
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