CN1723959A - Method for preparing medicine for treating cataclasis and soft tissue injury - Google Patents
Method for preparing medicine for treating cataclasis and soft tissue injury Download PDFInfo
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- CN1723959A CN1723959A CNA2005100126706A CN200510012670A CN1723959A CN 1723959 A CN1723959 A CN 1723959A CN A2005100126706 A CNA2005100126706 A CN A2005100126706A CN 200510012670 A CN200510012670 A CN 200510012670A CN 1723959 A CN1723959 A CN 1723959A
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- eremiatis
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- tissue injury
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- 239000003814 drug Substances 0.000 title claims abstract description 46
- 208000026137 Soft tissue injury Diseases 0.000 title claims abstract description 11
- 238000000034 method Methods 0.000 title description 15
- 239000002775 capsule Substances 0.000 claims abstract description 28
- 238000001035 drying Methods 0.000 claims abstract description 15
- 238000010298 pulverizing process Methods 0.000 claims abstract description 7
- 238000003756 stirring Methods 0.000 claims abstract description 7
- 239000000843 powder Substances 0.000 claims description 35
- 238000002360 preparation method Methods 0.000 claims description 16
- 229940079593 drug Drugs 0.000 claims description 15
- 208000010392 Bone Fractures Diseases 0.000 claims description 14
- 238000011282 treatment Methods 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 241000927985 Argis Species 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 238000011049 filling Methods 0.000 claims description 2
- 210000000988 bone and bone Anatomy 0.000 abstract description 27
- 238000011068 loading method Methods 0.000 abstract description 6
- 238000002156 mixing Methods 0.000 abstract description 4
- 241000270322 Lepidosauria Species 0.000 abstract 3
- 244000281702 Dioscorea villosa Species 0.000 abstract 1
- 241001116742 Drynaria Species 0.000 abstract 1
- 206010061363 Skeletal injury Diseases 0.000 abstract 1
- 206010017076 Fracture Diseases 0.000 description 10
- 238000010521 absorption reaction Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000002552 dosage form Substances 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000018109 developmental process Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000857 drug effect Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000238370 Sepia Species 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000009172 bursting Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000008298 dragée Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
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- 238000011069 regeneration method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 229940126589 solid medicine Drugs 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000007940 sugar coated tablet Substances 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
A Chinese medicine in the form of capsules for treating bone and soft tissue injury is prepared from lizard, drynaria rhizome and yam rhizome through mixing half of lizard with others, decocting three times, collecting the decoction, concentrating, adding the residue of lizard, stirring, drying, pulverizing, and loading in capsules.
Description
Affiliated technical field
The invention belongs to field of medicine producing technology, be specifically related to a kind of preparation method for the treatment of fracture and soft tissue injury medicine.This medicine is collected in Ministry of Health of the People's Republic of China's " Chinese traditional patent formulation preparation " drug standard with Tabules, and the present invention provides the preparation method of this medicine as the capsule dosage form.
Background technology
Chinese medicine is the rarity of the Chinese nation.Inheriting and the development Chinese medicine, make it to combine with the modern medicine technology, is to make Chinese medicine step into the key point of international market.The kind of from the Chinese patent medicine kind of domestic list marketing, screening reasonable recipe, determined curative effect, make full use of modern pharmaceutical new technique, new technology, new equipment, the production process route and the process that fall behind are relatively improved, producing the new Chinese medicine of dosage form advanced person, safe and effective, quality homogeneous, is the important topic of Chinese medicine development, exploitation.
Fracture, soft tissue injury are clinically commonly encountered diseases and frequently-occurring disease, and the conventional treatments after fracturing is to use plaster fixation after fracture is resetted, and relies on the regeneration capacity normal healing of skeleton self; More serious fracture then needs operative treatment, with draw point and steel plate fracture is fixed.These fractures methods are painful greatly, healing time is long, brought inconvenience to the patient.By endo-medicine the effect of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain is arranged not only, also have the function of reunion of fractured tendons and bones, test or clinical research confirm that also union of fracture exists the medicine factor in a large number, use the effect that treatment by Chinese herbs has accelerating union of bone fracture.
The reunion of bone sheet is the Chinese patent medicine commonly used that derives from the Drug Standard of Ministry of Public Health of the Peoples Republic of China " Chinese traditional patent formulation preparation ", records in the 11st the 170th page standard numbering WS
3-B-2226-96.Its prescription is Eremiatis argi 500g, Rhizoma Drynariae 333g, Rhizoma Dioscoreae Nipponicae 167g, concrete method for making is to get half amount Eremiatis argi to be ground into fine powder, residue Eremiatis argi and Rhizoma Drynariae, Rhizoma Dioscoreae Nipponicae decoct with water three times, and each 2 hours, collecting decoction, filter, filtrate is condensed into clear paste, adds Eremiatis argi fine powder mixing, adds appropriate amount of auxiliary materials and makes granule, be pressed into 1000, sugar coating.The reunion of bone sheet has the effect of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, is mainly used in treatment soft tissue injury, fracture etc.
Find that in long-term production and clinical practice there is following some deficiency in former reunion of bone sheet:
1, it is more to contain the former powder of Eremiatis argi in the reunion of bone sheet, and Eremiatis argi is an animal medicinal material, contains a large amount of oil substances, and the elasticity of granulation and tabletting dynamics are difficult to be complementary, when pellet hardness big, the little just sliver easily of tabletting dynamics; When pellet hardness is little, the tabletting great efforts just are difficult to disintegrate, even disintegration time surpasses 60 minutes, the tabletting of having to pulverize again.Owing to the oil substances content difference between every batch of former powder of Eremiatis argi is very big, be difficult to control under the suitable process conditions, the elasticity and the tabletting dynamics of granulation are complementary, the tablet or the disintegration time that cause final production to go out reach 30～60 minutes, drug dissolution is relatively poor, influences absorption of human body; Perhaps label the phenomenon of bursting apart occurs through regular meeting aborning, the tabletting of having to pulverize again.
2, every of former reunion of bone sheet only contains crude drug amount 1g, and it is little to contain the crude drug amount, and the patient need take 5 at every turn, and dose is big.If want to strengthen the crude drug amount, just must add large stretch of heavy and volume, both increased the difficulty of tabletting, also taking to the patient has increased difficulty.
3, former reunion of bone sheet is a sugar coated tablet, the easy moisture absorption, and storage difficulties, and also diabetics can not take, and limited the crowd of taking to a certain extent.
Summary of the invention
The purpose of this invention is to provide the preparation method of this medicine as the capsule dosage form, the capsule of this method preparation, disintegration time is fast, easily be absorbed by the body, and dose is little.
It is that Chinese medicine crude drug by following portions by weight prepares that the present invention treats fracture and the capsule of soft tissue injury:
Eremiatis argi 625 Rhizoma Drynariae 416.25 Rhizoma Dioscoreae Nipponicae 208.75
The concrete preparation method of this medicine is:
A) get 312.5 parts of Eremiatis argis and be ground into fine powder;
B) 312.5 parts of Eremiatis argis of residue decoct with water three times with 416.25 parts of Rhizoma Drynariae, 208.75 portions of Rhizoma Dioscoreae Nipponicae, and each amount of water is followed successively by 13 times, 8 times, 8 times of crude drug amount, each decocting time 2 hours;
C) merge three decocting liquids, be condensed into the clear paste of 50 ℃ of relative densities 1.15～1.20 after the filtration;
D) the Eremiatis argi fine powder is joined in the clear paste, stir, be packed into capsule after the drying and crushing.
Wherein, the pulverizing of Eremiatis argi is that 312.5 parts of Eremiatis argis are become 80～100 purpose fine powders in low temperature dry pulverization process below 0 ℃ in placement under the dry environment below 0 ℃ after 12 hours, and the present invention generally adopts-50～0 ℃.Adopt such disintegrating process, both easily Eremiatis argi was pulverized, improved the flour extraction of Eremiatis argi again, guaranteed the crude drug amount that contains of preparation, also reduced the moisture absorption of preparation.Adopt above-mentioned disintegrating process, the average flour extraction of Eremiatis argi can reach 95.5%.
The present invention is the pressure with 0.05Mpa, and the relative density that under 70 ℃ extraction is obtained is that the clear paste of 1.15～1.20 (50 ℃) carries out vacuum dehydrating at lower temperature, and after being ground into 65 purpose medicated powder, is used for the filling capsule agent.
The present invention adopts 70 ℃ of atmospheric low-temperatures dryings and 0.05Mpa, two kinds of drying modes of 70 ℃ of vacuum dehydrating at lower temperature that clear paste is carried out drying respectively, and the result compared, the result shows that the drying time of vacuum dehydrating at lower temperature is short, the finished product lighter color, particularly dried cream powder is little angle of repose, good fluidity (seeing Table 1).
The result of two kinds of drying modes of table 1 relatively
Drying mode drying time (h) color and luster moisture absorption angle of repose
General 39 ° of dry 140 pitchies of atmospheric low-temperature
General 38 ° of vacuum dehydrating at lower temperature 82 sepias
When carrying out vacuum dehydrating at lower temperature, whether suitable the relative density of clear paste is, not only can directly influence the drying time and the product quality of product, also can influence the complexity that next step adds the Eremiatis argi powder.The density of degree mutually of clear paste is 1.10～1.15 (50 ℃), and drying time is longer; When relative density was 1.20～1.30 (50 ℃), though shorten drying time, the sample caking was harder, was difficult for pulverizing, and the Eremiatis argi powder of adding still can not mix with clear paste after stirring 30 minutes very equably; Relative density is the clear paste of 1.15～1.20 (50 ℃), not only drying time moderate, sample is ground into fine powder easily, and the Eremiatis argi powder adds in the clear paste, only needs to stir about 10 minutes, just can easily admix in the clear paste, with the abundant mix homogeneously of clear paste.
Dried medicated powder fineness size can directly influence the flowability and the capsular loadings of medicated powder, the present invention adopts the fixed funnel method, measure the angle of repose (tga=H/R) and the loadings (seeing Table 2) of different mesh sieve medicated powder respectively, result of the test shows, the angle of repose of 65 order medicated powder is little, mobile big, and bulk density is also big, and the capsule loadings is many.
Determining of table 2 capsule model and loading amount
Average loading amount (g)
Powder size average density (g/ml) average angle of repose of capsule model
Theoretical actual
0 0.47 0.35
0.70 45 ° in 100 orders
1 0.40 0.28
0 0.48 0.40
0.72 37 ° in 65 orders
1 0.41 0.30
0 0.42 0.35
0.62 37 ° in 50 orders
1 0.35 0.28 " 0 " numbers the capsule volume is 0.67ml, and " 1 " number capsule volume is 0.57ml.
After tested, the capsular disintegration time of reunion of bone of the present invention only is 3～5 minutes, and the disintegration time of reunion of bone sheet was generally 30～60 minutes, and the capsular disintegration time of reunion of bone has shortened 25～55 minutes than reunion of bone sheet.Because the oral administration solid medicine at first need disintegrate in gastrointestinal, and then the stripping medicine, absorb and enter in the body, therefore, reunion of bone pharmaceutical capsules of the present invention absorbs and enters human body, and the time of performance drug effect is also obviously faster than the reunion of bone sheet.
In addition, what reunion of bone capsule of the present invention was filled is 65 purpose medicated powder, disintegrate is about 65 purpose powder in gastrointestinal, the easy stripping of medicine, and the reunion of bone sheet is to be formed by 14～18 purpose granule tablettings, disintegrate is about 14～18 purpose granules in gastrointestinal, and medicine is difficult to stripping, and the time of reunion of bone capsule drug effect performance is also certainly faster than the reunion of bone sheet.
Every heavy 0.40g of the reunion of bone capsule of the present invention preparation, containing the crude drug amount is the 1.25g/ grain, and the reunion of bone sheet contains the crude drug amount and only is the 1g/ sheet, every reunion of bone capsule is equivalent to 1.25 reunion of bone sheets.Reunion of bone capsule method of administration is every day 3 times, and each 4, reunion of bone sheet method of administration is every day 3 times, each 5, use reunion of bone capsule of the present invention, and reduced the dose of medicine.
The critical relative humidity size of dry back cream powder, the size that famous special product is influenced by air humidity.Because the former powder of Eremiatis argi among the present invention is 0 ℃ of following pulverize at low temperature, crushed after being dried is that 65 purpose medicated powder are little, mobile big angle of repose, bulk density is big, critical relative humidity is 72% after tested, 45～65% critical relative humidity technological requirements far below oral solid formulation workshop clean area, medicated powder is difficult for the moisture absorption, and is encapsulated easily, the quality of easier assurance product.
The specific embodiment
Embodiment 1
Get Eremiatis argi 312.5g, after placing 12 hours under 0 ℃ the dry environment, become 80 orders, obtain the 297.5g fine powder in 0 ℃ of low temperature dry pulverization process.
Get the 312.5g Eremiatis argi and decoct with water three times with 416.25g Rhizoma Drynariae, 208.75g Rhizoma Dioscoreae Nipponicae, each amount of water is followed successively by 13 times, 8 times, 8 times of crude drug amount, each decocting time 2 hours.Merge three times decocting liquid, be condensed into the clear paste of relative density 1.17 (50 ℃) after the filtration.
297.5g Eremiatis argi fine powder is joined in the clear paste, stir, after 82 hours, be ground into 65 orders at 70 ℃ of following vacuum dehydrating at lower temperature with the pressure of 0.05Mpa, obtain 384.7g medicated powder, add 65 purpose starch 15.3g, mixing packs 0 into
#In the capsule, every capsules dress 0.40g obtains 1000 reunion of bone capsules altogether.
Embodiment 2
Get Eremiatis argi 31.25Kg, after placing 12 hours under-40 ℃ the dry environment, become 100 orders, obtain the 29.98Kg fine powder in-40 ℃ of low temperature dry pulverization process.
Get the 31.25Kg Eremiatis argi and decoct with water three times with 41.625Kg Rhizoma Drynariae, 20.875Kg Rhizoma Dioscoreae Nipponicae, each amount of water is followed successively by 13 times, 8 times, 8 times of crude drug amount, each decocting time 2 hours.Merge three times decocting liquid, be condensed into the clear paste of relative density 1.18 (50 ℃) after the filtration.
29.75Kg Eremiatis argi fine powder is joined in the clear paste, stir, after 82 hours, be ground into 65 orders at 70 ℃ of following vacuum dehydrating at lower temperature with the pressure of 0.05Mpa, obtain 38.23Kg medicated powder, add 65 purpose starch 1.77Kg, mixing packs 0 into
#In the capsule, every capsules dress 0.40g obtains 97900 reunion of bone capsules altogether.
Claims (4)
1, a kind of fracture and preparation method of soft tissue injury medicine for the treatment of, this medicine are that the Chinese medicine crude drug by following portions by weight prepares:
Eremiatis argi 625 Rhizoma Drynariae 416.25 Rhizoma Dioscoreae Nipponicae 208.75
The preparation method that it is characterized in that this medicine is:
A) get 312.5 parts of Eremiatis argis and be ground into fine powder;
B) 312.5 parts of Eremiatis argis of residue decoct with water three times with 416.25 parts of Rhizoma Drynariae, 208.75 portions of Rhizoma Dioscoreae Nipponicae, and each amount of water is followed successively by 13 times, 8 times, 8 times of crude drug amount, each decocting time 2 hours;
C) merge three decocting liquids, be condensed into the clear paste of 50 ℃ of relative densities 1.15～1.20 after the filtration;
D) the Eremiatis argi fine powder is joined in the clear paste, stir, be packed into capsule after the drying and crushing.
2,, it is characterized in that 312.5 parts of Eremiatis argis after 12 hours, are become 80～100 purpose fine powders in-50～0 ℃ of dry pulverization process-50～0 ℃ of placement according to the preparation method of described treatment fracture of claim 1 and soft tissue injury medicine.
3, according to the preparation method of described treatment fracture of claim 1 and soft tissue injury medicine, the clear paste that it is characterized in that adding the Eremiatis argi fine powder carries out vacuum dehydrating at lower temperature with the pressure of 0.05Mpa at 70 ℃.
4,, it is characterized in that clear paste is ground into 65 purpose medicated powder filling capsules after drying according to the preparation method of described treatment fracture of claim 1 and soft tissue injury medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100126706A CN1329062C (en) | 2005-07-13 | 2005-07-13 | Method for preparing medicine for treating cataclasis and soft tissue injury |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005100126706A CN1329062C (en) | 2005-07-13 | 2005-07-13 | Method for preparing medicine for treating cataclasis and soft tissue injury |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1723959A true CN1723959A (en) | 2006-01-25 |
| CN1329062C CN1329062C (en) | 2007-08-01 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2005100126706A Active CN1329062C (en) | 2005-07-13 | 2005-07-13 | Method for preparing medicine for treating cataclasis and soft tissue injury |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107823382A (en) * | 2017-12-04 | 2018-03-23 | 安徽金太阳生化药业有限公司 | A kind of preparation method of reunion of bone capsule |
| CN108969627A (en) * | 2018-09-10 | 2018-12-11 | 路庆丽 | A kind of novel reunion of bone drug and preparation method thereof |
| CN113171349A (en) * | 2021-03-30 | 2021-07-27 | 天圣制药集团股份有限公司 | Film-coated tablet containing animal medicine and preparation process thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102038735B (en) * | 2010-12-24 | 2012-09-05 | 刘东鹏 | Traditional Chinese medicine slow-release particle medicinal porridge capable of accelerating fracture healing |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1150922C (en) * | 2001-02-21 | 2004-05-26 | 杨玉明 | A medicated liquor for treating arthralgia syndrome such as rheumatism and rheumatoid diseases |
-
2005
- 2005-07-13 CN CNB2005100126706A patent/CN1329062C/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107823382A (en) * | 2017-12-04 | 2018-03-23 | 安徽金太阳生化药业有限公司 | A kind of preparation method of reunion of bone capsule |
| CN108969627A (en) * | 2018-09-10 | 2018-12-11 | 路庆丽 | A kind of novel reunion of bone drug and preparation method thereof |
| CN113171349A (en) * | 2021-03-30 | 2021-07-27 | 天圣制药集团股份有限公司 | Film-coated tablet containing animal medicine and preparation process thereof |
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| Publication number | Publication date |
|---|---|
| CN1329062C (en) | 2007-08-01 |
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Effective date of registration: 20210825 Address after: 036000 high tech Industrial Park, Huairen County, Shuozhou City, Shanxi Province Patentee after: SHANXI HUAYUAN MEDICINE BIOTECHNOLOGY Co.,Ltd. Address before: 202, room 5, unit eight, jade garden, Yongle court District, Shanxi, Taiyuan 030027, China Patentee before: Wang Zhimin |