CN107823382A - A kind of preparation method of reunion of bone capsule - Google Patents
A kind of preparation method of reunion of bone capsule Download PDFInfo
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- CN107823382A CN107823382A CN201711258066.0A CN201711258066A CN107823382A CN 107823382 A CN107823382 A CN 107823382A CN 201711258066 A CN201711258066 A CN 201711258066A CN 107823382 A CN107823382 A CN 107823382A
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- reunion
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- sodium alginate
- bone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/583—Snakes; Lizards, e.g. chameleons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
- A61K36/12—Filicopsida or Pteridopsida
- A61K36/126—Drynaria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a kind of preparation method of reunion of bone capsule, first passes through decocting and the active ingredient of lizard, the rhizome of davallia, rhizoma dioscoreae nipponicae is extracted with the technique that cellulase degradation extraction is combined, and be condensed into thick paste；Then it is mixed evenly with sodium alginate soln, lizard dry powder, it is slow added into after being stirred in calcium chloride solution and stands, obtain embedding the sodium alginate gel of medicinal material and active component, powder finally is obtained by vacuum freeze drying, milled processed, reunion of bone capsule is obtained after filling capsule, packaging.The present invention is using sodium alginate as carrier material to the embedding treatment of active ingredients of medicinal materials; the active ingredient of medicinal material is set sufficiently to be protected in the gastrointestinal tract; holdup time is extended; intake of the intestines and stomach to active ingredient is improved; active ingredient is absorbed so as to improve human body; obtained reunion of bone capsule bioavilability is high, good effect.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, more particularly to a kind of preparation method of reunion of bone capsule.
Background technology
Reunion of bone capsule energy strengthening the bones and muscles, filling liver kidney, continue injured；The scattered stasis of blood is dispelled blood, continuous muscles and bones；Treat internal injury stasis caused pain, wound
Bleeding, detumescence；Warming meridian, promoting the circulation of qi detumescence, removes obstruction in channels to relieve pain；Myogenic sore, detoxifying and anticorrosive；It is mainly used in treating soft tissue damage
Wound, injury of tendon and muscle fracture, traumatic injury.The main component of reunion of bone capsule is lizard, the rhizome of davallia and rhizoma dioscoreae nipponicae, its current preparation
Method is to add water to cook lizard and the rhizome of davallia, rhizoma dioscoreae nipponicae for several times, collecting decoction, filtration, and filtrate is condensed into thick paste, then added
The fine powder that lizard crushes to obtain mixes, and is made after adding auxiliary material, granulation, filling capsule.Due to lizard main component include albumen,
Polypeptide and amino acid, these compositions are easily destroyed and digested in intestines and stomach when oral, cause that effect can not be given full play to,
Therefore, there is the defects of drug bioavailability is low in existing reunion of bone capsule preparation method thereof, it is impossible to the effect of more preferable is played,
It is necessary to make improvements it.
The content of the invention
A kind of the defects of the object of the invention is exactly to make up prior art, there is provided preparation method of reunion of bone capsule.
The present invention is achieved by the following technical solutions：
A kind of preparation method of reunion of bone capsule, comprises the following steps：
（1）120-150 parts by weight lizard, the 160-180 parts by weight rhizome of davallia, 80-100 parts by weight rhizoma dioscoreae nipponicae will be claimed to add extractor
In, first add decocting of 8-10 times equivalent to medicinal material gross weight and boil 2-4h, filter and collect filtrate, then 1-2 is added into filter residue
Part by weight of cellulose enzyme and water of 10-12 times equivalent to medicinal material gross weight the enzymolysis processing 2-4h under the conditions of 40-50 DEG C, pH5-6,
Filtered after 85-95 DEG C of enzyme deactivation 3-5min and collect filtrate, thick paste is condensed into after above filtrate is merged；
（2）By step（1）Obtained thick paste is with sodium alginate soln by weight 1：（0.5-1）It is well mixed, then add
120-150 parts by weight lizard dry powder stirs 10-15min in 1000-1500r/min, is slow added into molten equivalent to sodium alginate
0.5-1h is stirred in 400-600r/min in the calcium chloride solution of 0.5-1 times of liquid weight, is filtered after 4-6 DEG C of standing 1-2h, vacuum
Ground after freeze-drying uniformly, reunion of bone capsule is obtained after filling capsule, packaging.
The step（1）The temperature of middle concentration is 60-80 DEG C.
The step（1）The 1.35-1.38 when relative density of middle thick paste is 60 DEG C.
The lizard dry powder is 600-1000 mesh.
The mass fraction of the sodium alginate soln is 2-4%.
The mass fraction of the calcium chloride solution is 2-2.5%.
It is an advantage of the invention that：
The present invention first pass through decocting with the cellulase degradation technique that is combined of extraction to lizard, the rhizome of davallia, rhizoma dioscoreae nipponicae it is effective
Composition is extracted, and is condensed into thick paste；Then it is mixed evenly with sodium alginate soln, lizard dry powder, then slowly
Add in calcium chloride solution after stirring and stand, by crosslinked action of the calcium chloride to sodium alginate, by medicinal material and active component bag
It is embedded in inside sodium alginate gel, finally obtains powder by vacuum freeze drying, milled processed, obtained after filling capsule, packaging
To reunion of bone capsule.The present invention, to the embedding treatment of active ingredients of medicinal materials, makes lizard using sodium alginate as carrier material
Active ingredient albumen, polypeptide and amino acid are sufficiently protected in the gastrointestinal tract, and the holdup time is extended, while alginic acid
Sodium has mucosal adhesive performance, the intake of active ingredient is improved, so as to improve human body to having as good bioadhesive polymer
Effect composition absorbs.Reunion of bone capsule bioavilability produced by the present invention is high, good effect.
Embodiment
A kind of preparation method of reunion of bone capsule, comprises the following steps：
（1）120kg lizards, the 160kg rhizomes of davallia, 80kg rhizoma dioscoreae nipponicaes will be claimed to add in extractor, first added equivalent to medicinal material gross weight
2h is boiled in 8 times of decocting of amount, is filtered and is collected filtrate, then adds into filter residue 1 part by weight of cellulose enzyme and equivalent to medicinal material gross weight
The water of 10 times of amount filters after 40 DEG C, enzymolysis processing 2h under the conditions of pH5,85 DEG C enzyme deactivation 3min and collects filtrate, by above filtrate
Thick paste is condensed into after merging；
（2）By step（1）Obtained thick paste is with sodium alginate soln by weight 1：0.5 is well mixed, then adds 120kg lizards
Yi dry powder stirs 10min in 1000r/min, is slow added into calcium chloride solution of 0.5 times equivalent to sodium alginate soln weight
In in 400r/min stir 0.5h, 4 DEG C stand 1h after filter, ground after vacuum freeze drying it is uniform, after filling capsule, packaging
To reunion of bone capsule.
The step（1）The temperature of middle concentration is 60 DEG C.
The step（1）1.35 when the relative density of middle thick paste is 60 DEG C.
The lizard dry powder is 600 mesh.
The mass fraction of the sodium alginate soln is 2%.
The mass fraction of the calcium chloride solution is 2%.
Claims (6)
1. a kind of preparation method of reunion of bone capsule, it is characterised in that comprise the following steps：
（1）120-150 parts by weight lizard, the 160-180 parts by weight rhizome of davallia, 80-100 parts by weight rhizoma dioscoreae nipponicae will be claimed to add extractor
In, first add decocting of 8-10 times equivalent to medicinal material gross weight and boil 2-4h, filter and collect filtrate, then 1-2 is added into filter residue
Part by weight of cellulose enzyme and water of 10-12 times equivalent to medicinal material gross weight the enzymolysis processing 2-4h under the conditions of 40-50 DEG C, pH5-6,
Filtered after 85-95 DEG C of enzyme deactivation 3-5min and collect filtrate, thick paste is condensed into after above filtrate is merged；
（2）By step（1）Obtained thick paste is with sodium alginate soln by weight 1：（0.5-1）It is well mixed, then add
120-150 parts by weight lizard dry powder stirs 10-15min in 1000-1500r/min, is slow added into molten equivalent to sodium alginate
0.5-1h is stirred in 400-600r/min in the calcium chloride solution of 0.5-1 times of liquid weight, is filtered after 4-6 DEG C of standing 1-2h, vacuum
Ground after freeze-drying uniformly, reunion of bone capsule is obtained after filling capsule, packaging.
A kind of 2. preparation method of reunion of bone capsule according to claim 1, it is characterised in that the step（1）In
The temperature of concentration is 60-80 DEG C.
A kind of 3. preparation method of reunion of bone capsule according to claim 1, it is characterised in that the step（1）In
The 1.35-1.38 when relative density of thick paste is 60 DEG C.
4. the preparation method of a kind of reunion of bone capsule according to claim 1, it is characterised in that the lizard dry powder is
600-1000 mesh.
5. the preparation method of a kind of reunion of bone capsule according to claim 1, it is characterised in that the sodium alginate is molten
The mass fraction of liquid is 2-4%.
A kind of 6. preparation method of reunion of bone capsule according to claim 1, it is characterised in that the calcium chloride solution
Mass fraction be 2-2.5%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711258066.0A CN107823382A (en) | 2017-12-04 | 2017-12-04 | A kind of preparation method of reunion of bone capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711258066.0A CN107823382A (en) | 2017-12-04 | 2017-12-04 | A kind of preparation method of reunion of bone capsule |
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| Publication Number | Publication Date |
|---|---|
| CN107823382A true CN107823382A (en) | 2018-03-23 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711258066.0A Pending CN107823382A (en) | 2017-12-04 | 2017-12-04 | A kind of preparation method of reunion of bone capsule |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110664781A (en) * | 2019-10-22 | 2020-01-10 | 河南科技大学 | Preparation method of calcium alginate-loaded rhizoma drynariae microspheres with controllable particle size distribution |
| CN113171349A (en) * | 2021-03-30 | 2021-07-27 | 天圣制药集团股份有限公司 | Film-coated tablet containing animal medicine and preparation process thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1723959A (en) * | 2005-07-13 | 2006-01-25 | 王志敏 | Method for preparing medicine for treating cataclasis and soft tissue injury |
-
2017
- 2017-12-04 CN CN201711258066.0A patent/CN107823382A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1723959A (en) * | 2005-07-13 | 2006-01-25 | 王志敏 | Method for preparing medicine for treating cataclasis and soft tissue injury |
Non-Patent Citations (1)
| Title |
|---|
| 李芳等: "HPLC测定接骨续筋胶囊中柚皮苷的含量", 《现代中医药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110664781A (en) * | 2019-10-22 | 2020-01-10 | 河南科技大学 | Preparation method of calcium alginate-loaded rhizoma drynariae microspheres with controllable particle size distribution |
| CN113171349A (en) * | 2021-03-30 | 2021-07-27 | 天圣制药集团股份有限公司 | Film-coated tablet containing animal medicine and preparation process thereof |
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Application publication date: 20180323 |