CN101357225A - Preparation method of medicine for treating elderly cerebral dysfunction - Google Patents
Preparation method of medicine for treating elderly cerebral dysfunction Download PDFInfo
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- CN101357225A CN101357225A CNA2008103041510A CN200810304151A CN101357225A CN 101357225 A CN101357225 A CN 101357225A CN A2008103041510 A CNA2008103041510 A CN A2008103041510A CN 200810304151 A CN200810304151 A CN 200810304151A CN 101357225 A CN101357225 A CN 101357225A
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Abstract
The invention relates to the preparation method of biochemical and traditional Chinese medicine, in particular to the preparation method of a medicine which cures elderly brain dysfunction. The preparation method has the steps that a specified amount of fresh or brain issue after being frozen and melted are taken, purified, washed and added with physiological saline, processed by homogenate and offcenter, and then supernatant fluid is taken and processed by hyper filtration to get clear solution A; liquid above a film is blended together with sediments, and then is added with water of 10 times; the pH value is adjusted with hydrochloric acid, and pepsin is added and well stirring, heat preservation hydrolysis, standing and offcenter are carried out, and supernatant fluid B is taken, the supernatant fluid A and the supernatant fluid B are well blended and are spray-dried to get C for backup; a specified amount of ginseng are crashed to power D for backup; a specified shizandra berry, ophiopogon root, medlar, rehmanniae, and salvia miltiorrhiza are taken to carry out aqueous extract, consolidation, decoction solution and filtration, filtrate is decompressed to extract and is vacuumed and dried, and then is crushed to power E; the C, the D and the E are well blended to prepare the preparation. Nautral micro molecule polypeptide ingredients are extracted, the biological activity of the preparation is maintained, and the bioavailability is improved.
Description
Technical field
The present invention relates to biochemical medicine, preparation method of Chinese medicine, specifically is the preparation method of treatment elderly cerebral dysfunction medicine.
Background technology
In existing technology, compound brain activation and comfort capsule drug standard numbering: WS-10884ZD-0884-2002, writing out a prescription is Medulla sus domestica 2000g, Fructus Schisandrae Chinensis 200g, Radix Ophiopogonis 100g, Radix Ginseng 50g Fructus Lycii 50g, Radix Rehmanniae 50g, Radix Salviae Miltiorrhizae 50g, dextrin 2.5g, pepsin 60g makes 1000.Method for making: above seven flavor medicine material, the Radix Ginseng powder is broken into fine powder, and is standby.Medulla sus domestica adds water 1100ml homogenate, regulates pH value to 1.5～2.0 with hydrochloric acid, adds pepsin, stirs evenly, and 37～40 ℃ of insulations 8～10 hours, 100 ℃ of insulations 40 minutes, leaves standstill again, and is centrifugal, gets supernatant, and spray drying is standby.Five tastes medical materials such as all the other Fructus Schisandrae Chinensis decoct with water secondary, and 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate is concentrated into the thick paste that relative density is 1.30～1.35 (50 ℃), and drying is ground into fine powder, sieve,, incapsulate, promptly with above-mentioned fine powder and dextrin mixing.Function cures mainly: benefiting qi and nourishing blood, nourishing the brain and improving intelligence.Be used for forgetful deficiency of qi and blood card, hypomnesis, fatigue and weakness, dizzy cardiopalmus, and the improvement of the above symptom of alzheimer disease.Its shortcoming is the Medulla sus domestica direct hydrolysis have been destroyed the physiologically active of natural micromolecule polypeptide, and patient's taking dose is big, and medicament contg is low, and curative effect is low, and this technology is backward relatively.
Summary of the invention
The objective of the invention is provides a kind of preparation method of carrying out improved treatment elderly cerebral dysfunction medicine at preparation Medulla sus domestica polypeptide technology according to above-mentioned deficiency.
The concrete scheme of the present invention is: the preparation method of treatment elderly cerebral dysfunction medicine may further comprise the steps:
(1) used medicine material is 40 parts of Medulla sus domestica, 4 parts of Fructus Schisandrae Chinensis, 2 parts of Radix Ophiopogonis, 1 part of Radix Ginseng, 1 part of Fructus Lycii, 1 part of Radix Rehmanniae, 1 part of Radix Salviae Miltiorrhizae, 1.5 parts of pepsin;
(2) get pig brain tissue after the fresh or freeze thawing of ormal weight, decontamination, clean adds normal saline, homogenate, centrifugal, get supernatant, ultrafiltration gets solution A clearly, at first extracts natural micromolecule polypeptide composition, keep its physiologically active, avoid the later stage hydrolysis that natural micromolecule polypeptide is hydrolyzed into aminoacid, the separation preparation of micromolecule polypeptide has improved bioavailability; Liquid and precipitate blend on the film add 10 times of water gagings again, regulate pH value with hydrochloric acid, add pepsin, stir evenly, the insulation hydrolysis, leave standstill, centrifugal, get supernatant B, this step can be hydrolyzed into macro-molecular protein the aminoacid of micromolecule polypeptide and needed by human, be easy to see through blood brain barrier and absorb, improve bioavailability, with A, B liquid mix homogeneously, it is standby that spray drying gets C; Get the Radix Ginseng of ormal weight, it is standby to be ground into fine powder D; Get Fructus Schisandrae Chinensis, Radix Ophiopogonis, Fructus Lycii, Radix Rehmanniae, the Radix Salviae Miltiorrhizae of ormal weight, add 5 times of amounts of water, decoct secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, filtrate decompression simmer down to extractum, and vacuum drying is ground into fine powder E; With C, D, E mixing, make medicament.First extracting, hydrolysis have been adopted, extractive again technology path.
Described medicament is oral formulations commonly used such as capsule, tablet, granule, pill or oral liquid.
The advantage of invention: 1,, at first extract natural micromolecule polypeptide composition, keep its physiologically active by changing the Medulla sus domestica extracting method; 2, avoid the later stage hydrolysis that natural micromolecule polypeptide is hydrolyzed into aminoacid; 3, the separation preparation of micromolecule polypeptide has improved bioavailability.4, pharmacological research shows: neurotransmitter content in the experimental rat brain is had a significant effect, improve the animal learning memory ability.5, effective ingredient is made with extra care, and is keeping can reducing dose under original equal efficient functional situation.
Below in conjunction with embodiment embodiments of the present invention are described in further detail.
The specific embodiment
Treatment elderly cerebral dysfunction medicine (is example with the capsule), its preparation method may further comprise the steps:
1, used medicine material is 40 parts of Medulla sus domestica, 4 parts of Fructus Schisandrae Chinensis, 2 parts of Radix Ophiopogonis, 1 part of Radix Ginseng, 1 part of Fructus Lycii, 1 part of Radix Rehmanniae, 1 part of Radix Salviae Miltiorrhizae, 1.5 parts of pepsin.
2, get pig brain tissue after the fresh or freeze thawing of ormal weight, decontamination is cleaned, and adds 5 times and measure normal saline, homogenate, centrifugal, get supernatant, ultrafiltration gets solution A clearly; Liquid and precipitate blend on the film add 10 times of water gagings again, regulate pH value 1.5-2.0 with hydrochloric acid, add pepsin, stir evenly, and 35-42 ℃ of insulation 12 hours, leave standstill, and be centrifugal, gets supernatant B, and with A, B liquid mix homogeneously, it is standby that spray drying gets C.Get the Radix Ginseng of ormal weight, it is standby to be ground into fine powder D.Get Fructus Schisandrae Chinensis, Radix Ophiopogonis, Fructus Lycii, Radix Rehmanniae, the Radix Salviae Miltiorrhizae of ormal weight, add 5 times of amounts of water, decoct secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction, filter, filtrate decompression simmer down to extractum, vacuum drying is ground into fine powder E, C, D, E are mixed, add dextrin, batch mixing is even, makes capsule.
Claims (2)
1. preparation method for the treatment of the elderly cerebral dysfunction medicine is characterized in that may further comprise the steps:
(1) used medicine material is 40 parts of Medulla sus domestica, 4 parts of Fructus Schisandrae Chinensis, 2 parts of Radix Ophiopogonis, 1 part of Radix Ginseng, 1 part of Fructus Lycii, 1 part of Radix Rehmanniae, 1 part of Radix Salviae Miltiorrhizae, 1.5 parts of pepsin;
(2) get pig brain tissue after the fresh or freeze thawing of ormal weight, decontamination, clean, add normal saline, homogenate, centrifugal, get supernatant, ultrafiltration gets solution A clearly; Liquid and precipitate blend on the film add 10 times of water gagings again, use the hydrochloric acid regulated value, add pepsin, stir evenly, and the insulation hydrolysis is left standstill, and is centrifugal, gets supernatant B, and with A, B liquid mix homogeneously, it is standby that spray drying gets C; Get the Radix Ginseng of ormal weight, it is standby to be ground into fine powder D; Get Fructus Schisandrae Chinensis, Radix Ophiopogonis, Fructus Lycii, Radix Rehmanniae, the Radix Salviae Miltiorrhizae of ormal weight, add 5 times of amounts of water, decoct secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, filtrate decompression simmer down to extractum, and vacuum drying is ground into fine powder E; With C, D, E mixing, make medicament.
2. according to the preparation method of the described treatment elderly cerebral dysfunction of claim 1 medicine, it is characterized in that described medicament is capsule, tablet, granule, pill or oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008103041510A CN101357225A (en) | 2008-08-22 | 2008-08-22 | Preparation method of medicine for treating elderly cerebral dysfunction |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008103041510A CN101357225A (en) | 2008-08-22 | 2008-08-22 | Preparation method of medicine for treating elderly cerebral dysfunction |
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| CN101357225A true CN101357225A (en) | 2009-02-04 |
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| CNA2008103041510A Pending CN101357225A (en) | 2008-08-22 | 2008-08-22 | Preparation method of medicine for treating elderly cerebral dysfunction |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101518619B (en) * | 2009-04-02 | 2011-04-13 | 吉林省辉南长龙生化药业股份有限公司 | Compound brain activation and comfort capsule and quality control method thereof |
| CN108034487A (en) * | 2017-12-24 | 2018-05-15 | 广西南宁秀珀生物科技有限公司 | The enzymolysis and electric field compounding method of tuna leftover bits and pieces |
| CN109452653A (en) * | 2018-10-22 | 2019-03-12 | 广东羲准生物科技有限公司 | Join brain peptide composition and its application |
-
2008
- 2008-08-22 CN CNA2008103041510A patent/CN101357225A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101518619B (en) * | 2009-04-02 | 2011-04-13 | 吉林省辉南长龙生化药业股份有限公司 | Compound brain activation and comfort capsule and quality control method thereof |
| CN108034487A (en) * | 2017-12-24 | 2018-05-15 | 广西南宁秀珀生物科技有限公司 | The enzymolysis and electric field compounding method of tuna leftover bits and pieces |
| CN108034487B (en) * | 2017-12-24 | 2021-04-13 | 广西南宁秀珀生物科技有限公司 | Enzymolysis and electric field composite treatment method for tuna leftovers |
| CN109452653A (en) * | 2018-10-22 | 2019-03-12 | 广东羲准生物科技有限公司 | Join brain peptide composition and its application |
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Open date: 20090204 |