CN1736471A - Ginger preparation and preparation process thereof - Google Patents
Ginger preparation and preparation process thereof Download PDFInfo
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- CN1736471A CN1736471A CN 200510200492 CN200510200492A CN1736471A CN 1736471 A CN1736471 A CN 1736471A CN 200510200492 CN200510200492 CN 200510200492 CN 200510200492 A CN200510200492 A CN 200510200492A CN 1736471 A CN1736471 A CN 1736471A
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Abstract
The invention provides ginger preparation and preparation process, wherein the preparation is prepared from brown sugar and ginger powder, and is made into the forms of dispersible tablets, effervescent tablets and granules, the weight ratio of the brown sugar and ginger powder is 80:20.
Description
Technical field: the present invention is a kind of processed with Rhizoma Zingiberis Recens agent and preparation method thereof, belongs to the technical field that food has the product of pharmacodynamic feature concurrently.
Technical background: Rhizoma Zingiberis Recens has relieving the exterior syndrome by diaphoresis, the effect of warming middle-JIAO to arrest vomiting, Compendium of Material Medica record " Rhizoma Zingiberis Recens removes wind and cold, ends headache, dredging the meridian, activating blood circulation to dissipate blood stasis ".But " but vegetables, can and, can the fruit medicine ".Rhizoma Zingiberis Recens and brown sugar decoct " ginger decoction " of gained, are the preparations of the medicine-food two-purpose of China's folk tradition, can be used for dispeling cold induce sweat, stomach function regulating preventing or arresting vomiting, appetite stimulator, promotion absorption and blood circulation.But ginger decoction decoction inconvenience can only family be used among a small circle, can't carry and store, and more impossiblely produces greatly, can not form product; In light of this situation, very be necessary said preparation is researched and developed, better bring into play the advantage of Chinese medicine food.
Summary of the invention: the objective of the invention is to: a kind of processed with Rhizoma Zingiberis Recens agent and preparation method thereof is provided; It carry, taking convenience, technology are rationally feasible, take also useful healthy for a long time.
The present invention constitutes like this: it mainly is all acceptable dosage forms on tablet, capsule, gel, dispersible tablet, soft capsule, microcapsule, granule, pill, micropill, powder, drop pill, slow releasing preparation, controlled release preparation, gastrointestinal location preparation, gel, oral liquid, soft extract, extractum and the membrane pharmaceutics that is made into by the part by weight hybrid process of 50-95: 50-5 by brown sugar and Rhizoma Zingiberis powder.Say accurately: described preparation is dispersible tablet, effervescent tablet, granule, tablet.Brown sugar and Rhizoma Zingiberis powder are pressed 80: 20 mixed.
The preparation method of processed with Rhizoma Zingiberis Recens agent of the present invention: it mainly is all acceptable dosage forms on tablet, capsule, gel, dispersible tablet, soft capsule, microcapsule, granule, pill, micropill, powder, drop pill, slow releasing preparation, controlled release preparation, gastrointestinal location preparation, gel, oral liquid, soft extract, extractum and the membrane pharmaceutics of being manufactured by brown sugar and Rhizoma Zingiberis powder.
Specifically: manufacture dispersible tablet, effervescent tablet, granule, tablet with brown sugar and Rhizoma Zingiberis powder; Brown sugar and Rhizoma Zingiberis powder mix by 80: 20 part by weight.
The preparation method of described processed with Rhizoma Zingiberis Recens agent: get Jiang Qingxi: wash Rhizoma Zingiberis Recens, water is dried, air dried Rhizoma Zingiberis Recens is put into the baking oven baking that temperature is controlled between 40 ℃-50 ℃ and does to eight-ninety percent, with the Rhizoma Zingiberis powder after the oven dry broken be coarse grain, with the coarse grain of Rhizoma Zingiberis Recens with till being squeezed to no juice outflow; With the Rhizoma Zingiberis Recens residue after squeezing the juice be controlled at oven dry in 40 ℃-60 ℃ the baking oven in temperature, residue after will dry smashes, and crosses 100 mesh sieves, must the Rhizoma Zingiberis Recens dregs powder; The Sucus Zingberis crushed after being dried is made the Sucus Zingberis powder; The Sucus Zingberis powder mixes with the Rhizoma Zingiberis Recens dregs powder and obtains Rhizoma Zingiberis powder; Brown sugar and Rhizoma Zingiberis powder are mixed, beat powder, mistake 60 mesh sieves add that suitable adjuvant makes the processed with Rhizoma Zingiberis Recens agent after brown sugar and Rhizoma Zingiberis powder be mixed in proportion.
Dispersible tablet among the present invention is preparation like this: with the Rhizoma Zingiberis Recens dregs powder, brown sugar, Sucus Zingberis powder mix, cross 120 mesh sieves; Disintegrating agent, fluidizer and filler mix, and pulverize, and cross 120 mesh sieves, and with Rhizoma Zingiberis Recens dregs powder, brown sugar, the mixture of Sucus Zingberis powder mixes, and adds binding agent again or directly uses an amount of Sucus Zingberis as binding agent, pelletize, drying, granulate; With the granule that makes and lubricant, disintegrating agent, mix, tabletting, promptly.Wherein: in to add 5% crosslinked polyethylene pyrrole Lip river alkane ketone be disintegrating agent, 2% micropowder silica gel is a fluidizer, 3% mannitol is filler, Sucus Zingberis is as binding agent, 2% magnesium stearate is a lubricant, adding 3% crosslinked polyethylene pyrrole Lip river alkane ketone is disintegrating agent.
Effervescent tablet among the present invention is preparation like this: with the Rhizoma Zingiberis Recens dregs powder, and brown powdered sugar, the mixture of Sucus Zingberis powder mixes with gas-producing disintegrant, adds binding agent, pelletize, drying, granulate; Add gas-producing disintegrant and mix lubricant, tabletting, promptly.Wherein: in add 7% sodium bicarbonate and 6% citric acid mixture be gas-producing disintegrant, the mixture that adds 3% sodium bicarbonate and 4% citric acid is a gas-producing disintegrant, 1% magnesium stearate is a lubricant.
Granule among the present invention is preparation like this: with the Rhizoma Zingiberis Recens dregs powder, and brown powdered sugar, the Sucus Zingberis powder mixes, and adds 1.5% lactose, adds the moistening back of ethanol and granulates, and makes granule, or the bag film-coat, 50 ℃ of coating temperature, hydroxypropyl methylcellulose 60% dissolve with ethanol, promptly.
Tablet among the present invention is preparation like this: with the Rhizoma Zingiberis Recens dregs powder, and brown powdered sugar, the Sucus Zingberis powder mixes, and add the moistening back of ethanol and granulate, or granulate with the part Sucus Zingberis, drying, tabletting, promptly.
Prior art is compared, and preparation provided by the invention is at prior art, and the effervescent tablet that provides, dispersible tablet, granule, tablet carry, take, storage, convenient transportation, good mouthfeel, and market prospect is wide.Product has relieving the exterior syndrome by diaphoresis, the effect of warming middle-JIAO to arrest vomiting, can be used for dispeling cold induce sweat, stomach function regulating preventing or arresting vomiting, appetite stimulator, promotion absorption and blood circulation.
The applicant finds in development process: this product is because contain brown sugar, so hygroscopicity, viscosity are bigger, causes disintegrate, the difficulties in dispersion of dispersible tablet, effervescent tablet; The easy moisture and deteriorate of granule tablet.In order to improve these problems, the applicant has carried out a series of experiments, with the supplementary product kind of the preparation process condition of selecting pharmaceutical preparation provided by the invention, use and consumption, ratio etc.; Guarantee its science, reasonable, feasible; Make the preparation that obtains have effective therapeutic effect.Particularly the kind of adjuvant and consumption are crucial, and for example the kind of The disintegrating agents of dispersible tablets and consumption are most important to disintegrate, the result of extraction of dispersible tablet, are the factors that at first will consider; Even same disintegrating agent, the difference on the consumption also may produce diametrically opposite effect to the disintegrate behavior of dispersible tablet.
Experimental example 1: Study on Forming
(1) dispersible tablet Study on Forming
(1) disintegrating agent is selected
Carry out the tabletting test, the results are shown in following table.
Disintegrating agent is selected
| Disintegrating agent | Consumption | Situation is uniformly dispersed |
| Carboxymethyl starch sodium (CMS-Na), | 5％ | Disperse general |
| Crospolyvinylpyrrolidone (PVPP) | 5％ | Be uniformly dispersed, good |
| Cross-linking sodium carboxymethyl cellulose (CCMC-Na) | 5％ | Disperse general |
| Low-substituted hydroxypropyl cellulose (LS-HPC) | 5％ | Disperse bad |
(2) binding agent is selected
Take by weighing supplementary material by prescription, be divided into 3 equal portions, granulate with water, 95% ethanol, 5% starch slurry, Sucus Zingberis respectively, granulate, tabletting is investigated granule situation, the outward appearance of sheet and the situation that is uniformly dispersed, and the results are shown in following table.
Binding agent is selected
| Binding agent | The granule situation | The sheet outward appearance | Situation is uniformly dispersed | |
| Sample 1 | Water | Easily lump, granule is pine | Unilateral have piebaldism, burr, a tabletting difficulty | Disperse bad |
| Sample 2 | 95% ethanol | Granule is better, and granule is suitable | Unilateral color even,, mouthfeel is good | Be uniformly dispersed, good |
| Sample 3 | 5% starch slurry | Granule is tight | Unilateral flower slightly, burr, mouthfeel are hard | Disperse general |
| Sample 4 | Sucus Zingberis | Granulating efficiency is good, and granule is suitable | Unilateral color even, attractive in appearance, mouthfeel good | Be uniformly dispersed, good |
By above experimental result as can be known, be that the gained granule was soft after binding agent was granulated with Sucus Zingberis, unilateral color even, attractive in appearance, disintegration time is short, so select to granulate with Sucus Zingberis.
(3) the fluidizer consumption is selected
Get the supplementary material of recipe quantity, by method for making granulation, granulate, the gained granule is divided into 4 parts, the consumption that adds micropowder silica gel respectively is 0%, 1%, 2%, 2.5%, mixing, and the disintegration time behind mensuration granule angle of repose and the tabletting the results are shown in following table.
The fluidizer consumption is selected
| Micropowder silica gel consumption (%) | Angle of repose | Disintegration time (second) | |
| 1 | 0 | 47.2° | 82 |
| 2 | 1 | 45.3° | 78 |
| 3 | 2 | 43.7° | 74 |
| 4 | 2.5 | 44.0° | 76 |
Annotate: measure angle of repose and adopt the dump box method, promptly fill granule in rectangular box, its Strobilus Pini degree is suitable, and till box was progressively tilted to granule and begins to flow out, the angle that box tilts was angle of repose.
Above experimental result shows, after adding micropowder silica gel, can significantly improve particulate flowability, and the micropowder silica gel addition is that 2% o'clock mobility of particle is better, so selection micropowder silica gel addition is 2%.
(4) lubricant quantity is selected
Get the supplementary material of recipe quantity,, the gained granule is divided into 3 parts, add magnesium stearate 0%, 1%, 2% respectively by method for making granulation, granulate, mixing, tabletting, the outward appearance and the disintegration time of observation sheet, the result is as seeing the following form.
Lubricant quantity is selected
| Lubricant quantity (%) | The sheet outward appearance | Disintegration time (second) | |
| 1 | 0 | Unilateral more coarse | 78 |
| 2 | 1 | Unilateral coarse slightly | 79 |
| 3 | 2 | Unilateral more smooth, attractive in appearance | 81 |
By above result of the test as can be known, unilateral smooth, attractive in appearance when the magnesium stearate consumption is 2%, disintegration time changes not quite simultaneously, is 2% so select the magnesium stearate addition.
The result shows, dispersible tablet is that such preparing product is functional: in to add 5% crosslinked polyethylene pyrrole Lip river alkane ketone be disintegrating agent, 2% micropowder silica gel is a fluidizer, 3% mannitol is filler, Sucus Zingberis is as binding agent, 2% magnesium stearate is a lubricant, and adding 3% crosslinked polyethylene pyrrole Lip river alkane ketone is disintegrating agent.
(2) effervescent tablet Study on Forming
PH value is measured: get 1 of this product, effervescent is scattered in 20 ℃ of distilled water of 100ml, measure the pH value of solution.
Check disintegration: get 1 of this product, put in the 250ml beaker, add 45～55 ℃ of hot water 200ml in the beaker, have a large amount of bubbles to emit, when gas stopped to overflow, tablet should be dissolved or dispersed in the water, and it is left not have accumulative granule.By inspection technique check disintegration, get 6 of this product, check all disintegrates in 5min of each sheet as stated above.
Hardness is investigated: the effervescent tablet that makes under each experimental condition is carried out aluminium-plastic bubble plate packing, respectively at the 0th day and sampling on the 30th, measure radial stiffness.
| Citric acid | Sodium bicarbonate | Disintegration | PH value | Hardness kg | |||
| In add % | Add % | In add % | Add % | s | 0 day | 30 days | |
| 0 3 5 7 9 10 | 10 7 5 3 1 0 | 0 2 4 6 8 10 | 10 8 6 4 2 0 | 125 149 102 89 113 99 | 5.36 5.68 6.12 6.32 7.01 6.89 | 6.11 6.21 5.99 5.98 6.07 5.65 | 2.34 2.11 4.75 5.92 5.97 3.73 |
The result shows, the ratio of preferred by experiment citric acid and sodium bicarbonate, make effervescent bring into play optimum efficiency: in add 7% sodium bicarbonate and 6% citric acid mixture be gas-producing disintegrant, the mixture that adds 3% sodium bicarbonate and 4% citric acid is a gas-producing disintegrant, and 1% magnesium stearate is a lubricant.Prescription of the present invention, preparation technology are simple, steady quality, easily control, and palatability is strong, and has than conventional tablet onset characteristics rapidly, can make things convenient for the patient of old man and dysphagia to take.
(3) granule Study on Forming
The percentile mensuration of moisture absorption: get a certain amount of extract powder, put constant weight 48h in the phosphorus pentoxide desiccator.The glass exsiccator that the bottom is filled the sodium chloride supersaturated solution is put into 25 ℃ constant incubator constant temperature 24h, and the interior relative humidity of exsiccator this moment is 75%.Put into the medicated powder of thick about 2mm in the weighing botle bottom of constant weight, accurately weighing is placed on above-mentioned glass exsiccator interior (the weighing bottle cap is opened) in 25 ℃ of preservations, and regularly (6,12,24,48,60h) weighing is calculated as follows the moisture absorption percentage rate.
Hydroscopicity (%)=(medicated powder weight after the moisture absorption-moisture absorption prodrug grain weight amount)/moisture absorption prodrug grain weight amount * 100%
| 1. grouping: | Group | The coating temperature (℃) | Concentration of alcohol (%) |
| 1 2 3 4 5 6 | 40 40 50 50 60 60 | 60 80 60 80 60 Rn |
| 2. result: | Group | 1 | 2 | 3 | 4 | 5 | 6 |
| Hydroscopicity (%) | 3.79 | 4.21 | 3.40 | 3.76 | 4.23 | 4.13 |
(4) tablet Study on Forming:
(1) binding agent is selected
Take by weighing supplementary material by prescription, be divided into 3 equal portions, granulate granulate with water, 95% ethanol, 5% starch slurry, Sucus Zingberis respectively.Tabletting.Investigate the outward appearance and the disintegration time of granule situation, sheet, the results are shown in following table.
Binding agent is selected
| Binding agent | The granule situation | The sheet outward appearance | Disintegration time (second) | |
| Sample 1 | Water | Easily lump, granule is pine | Unilateral have piebaldism, burr, a tabletting difficulty | 82 |
| Sample 2 | 95% ethanol | Granule is effective, and granule is suitable | Unilateral color even is attractive in appearance, mouthfeel good | 85 |
| Sample 3 | 5% starch slurry | Granule is tight | Unilateral flower slightly, burr, mouthfeel are hard | 92 |
| Sample 4 | Sucus Zingberis | Granulating efficiency is good, and granule is suitable | Unilateral color even, attractive in appearance, mouthfeel good | 80 |
By above experimental result as can be known, be that the gained granule was effective after binding agent was granulated with Sucus Zingberis or with 95% ethanol, granule is suitable, unilateral color even, attractive in appearance, disintegration time is fit to, so select with Sucus Zingberis or with 95% alcohol granulation.
(2) tablet high humidity experiment: getting three kinds of sheets, to put relative humidity be 92.5% (KNO
3Saturated solution) in the exsiccator, puts in 25 ℃ of constant incubators and observe 10d.
Average disintegration time: adopting changes the basket method, and lift disintegration tester, tablet or capsule are got 6 units, calculates the meansigma methods of passing through the screen cloth time fully.
| Types of coatings | Time (t/d) | Outward appearance | Hardness (kgm/s 2) | Disintegration (t/min) | Mass fraction (%) |
| The Film coated tablets coated tablet is coating not | 10 10 10 | White group white group white | 43.11±1.15 35.14±2.12 34.10±1.34 | 15±0.27 23±2.45 24±1.51 | 99.1±2.05 97.6±1.23 95.8±0.12 |
Experimental example 2: to the pharmacodynamic experiment of headache due to common cold
1. to the analgesic test of mice hot plate method
Get body weight 18～22g female mice, fasting, can't help water 12h after.On (55 ± 0.5) ℃ hot plate dolorimeter, measure the threshold of pain, with stopwatch record from mice drop into hot plate to the time of licking metapedes as threshold of pain index, survey the threshold of pain 1 time every 5min before the experiment, totally 2 times, get average.Choose position, the threshold of pain between 10～30s, stable reaction, the mice that do not jump use for experiment.Be divided into matched group, ginger decoction group, preparation group of the present invention at random, 10 every group.The threshold of pain is surveyed 1 time in grouping back 5min at interval, and totally 2 times, getting average is the preceding threshold of pain of administration; The same respectively method of 30min, 60min, 90min is surveyed the threshold of pain 2 times (matched group detur talis dosis water) again after the administration, and getting average is pain threshold after the administration.
| Analgesic activity pain threshold (s) to the mice hot plate method | |||||
| Group | Dosage (ml/kg) | 0min | 30min | 60min | 90min |
| Matched group ginger decoction group dispersible tablet group of the present invention effervescent tablet group of the present invention | 10 10 10 10 | 19.3±3.1 19.8±2.3 18.3±1.5 18.7±1.8 | 19.5±4.7 34.6±10.5 35.4±13.9 35.1±12.2 | 19.2±2.3 30.0±5.7 30.1±6.5 30.2±4.8 | 18.9±4.5 22.4±1.9 24.1±2.1 24.3±2.7 |
Found that preparation of the present invention can significantly improve the pain threshold of mice hot plate method, and effect is not less than the ginger decoction group.
2. mice acetic acid is caused the inhibition test of pain writhing response
Get male mice, body weight 18～24g is divided into matched group, ginger decoction group, preparation group of the present invention, 10 every group at random.Fasting, can't help water 12h.Administration then (matched group detur talis dosis water), behind the 45min, each Mus lumbar injection 1% acetum 0.3ml, each mice turns round the body number of times in the 10min that begins behind the 5min to count.Concrete data see Table 8.
The inhibitory action of table 8 pair mouse writhing reaction
| Group | Dosage (ml/kg) | Number of animals (only) | Turn round the body number of times (inferior/10min) |
| Matched group ginger decoction group granule group of the present invention tablet group of the present invention | 10 10 10 10 | 10 10 10 10 | 36±6 16±3 15±2 14±5 |
The result shows that preparation of the present invention has the inhibitory action of highly significant to mice acetic acid system pain writhing response.
3. the analgesic experiment of rabbit
The healthy qualified markon's Buddhist Buddhist nun subspecies rabbit of choosing, the male and female dual-purpose, body weight 2.1 ± 0.4kg, before the test in 9 o'clock every mornings and at 3 o'clock in afternoon each rabbit survey anus temperature 2 times, for three days on end, it is standby to be no more than 0.2 ℃ of person with the body temperature fluctuation, random packet, i.e. matched group, ginger decoction group, preparation group of the present invention is a basal body temperature with the mean of testing preceding 3 days body temperature.Buy the draft beer yeast and be mixed with 20% draft beer yeast suspension immediately with normal saline, press substance markers number and be the draft beer yeast suspension 1ml/kg pyrogenicity of each rabbit back subcutaneous injection 20% of preface, during pyrogenicity 2h, press 20ml/kg isometric(al) gastric infusion respectively, matched group is only given the isometric(al) normal saline, preparation 4g/kg of the present invention, after administration 1,2,3, each rabbit was surveyed the anus temperature each 1 time in 4,6 hours.
| To the draft beer yeast cause cold rabbit heating the increase that influences different time body temperature after the administration (℃) | |||||
| Group | 1h | 2h | 3h | 4h | 6h |
| Blank group ginger decoction group dispersible tablet group of the present invention effervescent tablet group of the present invention granule group of the present invention tablet group of the present invention | 1.23±0.21 0.65±0.37 0.66±0.14 0.67±0.18 0.67±0.09 0.65±0.21 | 1.49±0.23 0.76±0.21 0.72±0.19 0.71±0.17 0.73±0.05 0.74±0.21 | 0.41±0.40 0.68±0.16 0.59±0.10 0.58±0.31 0.60±0.11 0.62±0.34 | 1.26±0.32 0.64±0.20 0.58±0.32 0.56±0.41 0.60±0.25 0.61±0.43 | 0.90±0.11 0.45±0.20 0.42±0.16 0.41±0.19 0.43±0.13 0.44±0.21 |
The result: experimental data shows that rising has obvious inhibitory action to product of the present invention to rat temperature.
Among the present invention, selected brown sugar of inventor and Rhizoma Zingiberis powder are mixed with by the part by weight of 50-95: 50-5; Find in experiment: when the brown sugar ratio was higher than this ratio, effect was just not obvious and sweet excessively, and consumer is reluctant to take; When the Rhizoma Zingiberis powder ratio is too high, though effect is apparent in view, because taste is more pungent, so also influence is used; We have screened the ratio an of the best for this reason: brown sugar and Rhizoma Zingiberis powder mix by 80: 20 part by weight.
Concrete embodiment:
Embodiment 1: brown sugar 800g, Rhizoma Zingiberis powder 200g
Get Jiang Qingxi: clean commercially available Rhizoma Zingiberis Recens with domestic water, water is dried, air dried Rhizoma Zingiberis Recens is put into the baking oven baking that temperature is controlled between 40 ℃-50 ℃ and does to eight-ninety percent, with the Rhizoma Zingiberis powder after the oven dry broken be coarse grain, with the coarse grain of Rhizoma Zingiberis Recens with till being squeezed to no juice outflow; With the Rhizoma Zingiberis Recens residue after squeezing the juice be controlled at oven dry in 40 ℃-60 ℃ the baking oven in temperature, residue after will dry smashes, and crosses 100 mesh sieves, must the Rhizoma Zingiberis Recens dregs powder; Pulverize after the Sucus Zingberis lyophilization and make the Sucus Zingberis powder; The Sucus Zingberis powder mixes with the Rhizoma Zingiberis Recens dregs powder and obtains Rhizoma Zingiberis powder; Brown sugar and Rhizoma Zingiberis powder are mixed, beat powder, mistake 60 mesh sieves mixed 120 mesh sieves with brown sugar and Rhizoma Zingiberis powder by 80: 20 part by weight; In to add 5% crosslinked polyethylene pyrrole Lip river alkane ketone be disintegrating agent, 2% micropowder silica gel is a fluidizer, 3% mannitol is filler, pulverizes, and crosses 120 mesh sieves, mixes with the mixture of Rhizoma Zingiberis powder and brown powdered sugar, adds an amount of Sucus Zingberis as binding agent, pelletize, drying, granulate; With the granule and 2% magnesium stearate that make is lubricant, adds 3% crosslinked polyethylene pyrrole Lip river alkane ketone, mixes, and tabletting promptly gets dispersible tablet, and is oral, three times on the one, and once two.
Embodiment 2: brown sugar 950g, Rhizoma Zingiberis powder 50g
(1) processing of Rhizoma Zingiberis Recens is such:
1. clean with domestic water and clean commercially available old ginger, water is dried;
2. dry and air dried Rhizoma Zingiberis is put into the baking oven baking that temperature is controlled between 40 ℃-50 ℃ do to eight-ninety percent;
3. the Rhizoma Zingiberis powder after pulverizing will be dried is broken to be coarse grain;
4. squeeze the juice the coarse grain of Rhizoma Zingiberis Recens is squeezed to no juice and flows out with machine till;
(2) residue treatment of Rhizoma Zingiberis Recens is such:
1. the Rhizoma Zingiberis Recens residue after dry will the squeezing the juice is controlled at oven dry fully in 30 ℃-40 ℃ the baking oven in temperature;
2. the residue of pulverizing after will drying is smashed, and crosses 100 mesh sieves, gets the Rhizoma Zingiberis Recens dregs powder;
(3) processing of brown sugar is such: the brown sugar of bulk is beaten be less bulk, little blocky brown sugar and Rhizoma Zingiberis Recens dregs powder are mixed, beat powder, mistake 60 mesh sieves;
(4) processing of Sucus Zingberis: make the Sucus Zingberis powder after the Sucus Zingberis drying;
With the Rhizoma Zingiberis Recens dregs powder, brown sugar, the mixture of Sucus Zingberis powder is that gas-producing disintegrant mixes with the mixture of 7% sodium bicarbonate and 6% citric acid, adds binding agent, pelletize, drying, granulate; The mixture that adds 3% sodium bicarbonate and 4% citric acid is a gas-producing disintegrant, and 1% magnesium stearate is a lubricant, mixes, and tabletting promptly gets effervescent tablet.
Embodiment 3: brown sugar 500g, Rhizoma Zingiberis powder 500g
Get Jiang Qingxi: clean commercially available Rhizoma Zingiberis Recens with domestic water, water is dried, air dried Rhizoma Zingiberis Recens is put into the baking oven baking that temperature is controlled between 40 ℃-50 ℃ and does to eight-ninety percent, with the Rhizoma Zingiberis powder after the oven dry broken be coarse grain, with the coarse grain of Rhizoma Zingiberis Recens with till being squeezed to no juice outflow; With the Rhizoma Zingiberis Recens residue after squeezing the juice be controlled at oven dry in 30 ℃-40 ℃ the baking oven in temperature, residue after will dry smashes, and crosses 100 mesh sieves, must the Rhizoma Zingiberis Recens dregs powder; Pulverize after the Sucus Zingberis lyophilization and make the Sucus Zingberis powder; The Sucus Zingberis powder mixes with the Rhizoma Zingiberis Recens dregs powder and obtains Rhizoma Zingiberis powder; Brown sugar and Rhizoma Zingiberis powder are mixed, beat powder, mistake 60 mesh sieves mixed 120 mesh sieves with brown sugar and Rhizoma Zingiberis powder by 50: 50 part by weight; Add 1.5% lactose, add the moistening back of ethanol and granulate, make granule, or the bag film-coat, 50 ℃ of coating temperature, hydroxypropyl methylcellulose 60% dissolve with ethanol promptly gets granule.
Embodiment 4: brown sugar 800g, Rhizoma Zingiberis powder 200g
Get Jiang Qingxi: clean commercially available Rhizoma Zingiberis Recens with domestic water, water is dried, air dried Rhizoma Zingiberis Recens is put into the baking oven baking that temperature is controlled between 40 ℃-50 ℃ and does to eight-ninety percent, with the Rhizoma Zingiberis powder after the oven dry broken be coarse grain, with the coarse grain of Rhizoma Zingiberis Recens with till being squeezed to no juice outflow; With the Rhizoma Zingiberis Recens residue after squeezing the juice be controlled at oven dry in 30 ℃-40 ℃ the baking oven in temperature, residue after will dry smashes, and crosses 100 mesh sieves, must the Rhizoma Zingiberis Recens dregs powder; Pulverize after the Sucus Zingberis lyophilization and make the Sucus Zingberis powder; The Sucus Zingberis powder mixes with the Rhizoma Zingiberis Recens dregs powder and obtains Rhizoma Zingiberis powder; Brown sugar and Rhizoma Zingiberis powder are mixed, beat powder, mistake 60 mesh sieves mixed 120 mesh sieves with brown sugar and Rhizoma Zingiberis powder by 80: 20 part by weight; Add 2% methylcellulose, add the moistening back of ethanol and granulate, present embodiment also can or with an amount of Sucus Zingberis granulation, drying, tabletting promptly gets plain tablet.
Experimental example 5: brown sugar 700g, Rhizoma Zingiberis powder 300g
(1) processing of Rhizoma Zingiberis Recens is such:
1. clean with domestic water and clean commercially available old ginger, water is dried;
2. dry and air dried old ginger is put into the baking oven baking that temperature is controlled between 40 ℃-50 ℃ do to eight-ninety percent;
3. the Rhizoma Zingiberis powder after pulverizing will be dried is broken to be coarse grain;
4. squeeze the juice the coarse grain of Rhizoma Zingiberis Recens is squeezed to no juice outflow with the gauze parcel with hands till;
(2) residue treatment of Rhizoma Zingiberis Recens is such:
1. the Rhizoma Zingiberis Recens residue after dry will the squeezing the juice is controlled at oven dry fully in 30 ℃-40 ℃ the baking oven in temperature;
2. the residue of pulverizing after will drying is smashed, and crosses 100 mesh sieves;
(3) processing of brown sugar is such: the brown sugar of bulk is beaten be less bulk, little blocky brown sugar and Rhizoma Zingiberis Recens dregs powder are mixed, beat powder, mistake 60 mesh sieves;
(4) processing of Sucus Zingberis: Sucus Zingberis is made the Sucus Zingberis powder after adopting common dry technology drying;
With the Rhizoma Zingiberis Recens dregs powder, brown sugar, the Sucus Zingberis powder mixes, and adds soybean oil, becomes soft capsule according to prior art for preparing.
Experimental example 6: brown sugar 800Kg, Rhizoma Zingiberis powder 200Kg
(1) processing of Rhizoma Zingiberis Recens is such:
1. clean with domestic water and clean commercially available old ginger, water is dried;
2. dry and air dried old ginger is put into the baking oven baking that temperature is controlled between 40 ℃-50 ℃ do to eight-ninety percent;
3. the Rhizoma Zingiberis powder after pulverizing will be dried is broken to be coarse grain;
4. squeeze the juice with the coarse grain of Rhizoma Zingiberis Recens with the gauze parcel with hand till do not have juice and flow out;
(2) residue treatment of Rhizoma Zingiberis Recens is such:
1. the Rhizoma Zingiberis Recens residue after dry will the squeezing the juice is controlled at oven dry fully in 30 ℃-40 ℃ the baking oven in temperature;
2. the residue of pulverizing after will drying is smashed, and crosses 100 mesh sieves;
(3) processing of brown sugar is such: the brown sugar of bulk is beaten be less bulk, little blocky brown sugar and Rhizoma Zingiberis Recens dregs powder are mixed, beat powder, mistake 60 mesh sieves;
(4) processing of Sucus Zingberis: make the Sucus Zingberis powder after the Sucus Zingberis lyophilization;
With the Rhizoma Zingiberis Recens dregs powder, brown sugar, the Sucus Zingberis powder mixes, and granulates, and is encapsulated, promptly gets capsule.
Claims (9)
1. processed with Rhizoma Zingiberis Recens agent is characterized in that: it mainly is all acceptable dosage forms on tablet, capsule, gel, dispersible tablet, soft capsule, microcapsule, granule, pill, micropill, powder, drop pill, slow releasing preparation, controlled release preparation, gastrointestinal location preparation, gel, oral liquid, soft extract, extractum and the membrane pharmaceutics that is made into by the part by weight hybrid process of 50-95: 50-5 by brown sugar and Rhizoma Zingiberis powder.
2. according to the described processed with Rhizoma Zingiberis Recens agent of claim 1, it is characterized in that: manufacture dispersible tablet, effervescent tablet, granule, tablet with brown sugar and Rhizoma Zingiberis powder; Brown sugar and Rhizoma Zingiberis powder mix by 80: 20 part by weight.
3. the preparation method of processed with Rhizoma Zingiberis Recens agent described in claim 1 or 2 is characterized in that:
Get Jiang Qingxi: wash Rhizoma Zingiberis Recens, water is dried, air dried Rhizoma Zingiberis Recens is put into the baking oven baking that temperature is controlled between 40 ℃-50 ℃ and does to eight-ninety percent, with the Rhizoma Zingiberis powder after the oven dry broken be coarse grain, with the coarse grain of Rhizoma Zingiberis Recens with till being squeezed to no juice outflow; With the Rhizoma Zingiberis Recens residue after squeezing the juice be controlled at oven dry in 40 ℃-60 ℃ the baking oven in temperature, residue after will dry smashes, and crosses 100 mesh sieves, must the Rhizoma Zingiberis Recens dregs powder; The Sucus Zingberis crushed after being dried is made the Sucus Zingberis powder; The Sucus Zingberis powder mixes with the Rhizoma Zingiberis Recens dregs powder and obtains Rhizoma Zingiberis powder; Brown sugar and Rhizoma Zingiberis powder are mixed, beat powder, mistake 80 mesh sieves add that suitable adjuvant makes the processed with Rhizoma Zingiberis Recens agent after brown sugar and Rhizoma Zingiberis powder be mixed in proportion.
4. according to the preparation method of the described processed with Rhizoma Zingiberis Recens agent of claim 3, it is characterized in that: dispersible tablet is preparation like this: with the Rhizoma Zingiberis Recens dregs powder, brown sugar, Sucus Zingberis powder mix, cross 120 mesh sieves; Disintegrating agent, fluidizer and filler mix, and pulverize, and cross 120 mesh sieves, and with Rhizoma Zingiberis Recens dregs powder, brown sugar, the mixture of Sucus Zingberis powder mixes, and adds binding agent again or directly uses an amount of Sucus Zingberis as binding agent, pelletize, drying, granulate; With the granule that makes and lubricant, disintegrating agent, mix, tabletting, promptly.
5. according to the preparation method of the described processed with Rhizoma Zingiberis Recens agent of claim 4, it is characterized in that: in to add 5% crosslinked polyethylene pyrrole Lip river alkane ketone be disintegrating agent, 2% micropowder silica gel is a fluidizer, 3% mannitol is filler, Sucus Zingberis is as binding agent, 2% magnesium stearate is a lubricant, and adding 3% crosslinked polyethylene pyrrole Lip river alkane ketone is disintegrating agent.
6. according to the preparation method of the described processed with Rhizoma Zingiberis Recens agent of claim 3, it is characterized in that: effervescent tablet is preparation like this: with the Rhizoma Zingiberis Recens dregs powder, and brown powdered sugar, the mixture of Sucus Zingberis powder mixes with gas-producing disintegrant, adds binding agent, pelletize, drying, granulate; Add gas-producing disintegrant and mix lubricant, tabletting, promptly.
7. according to the preparation method of the described processed with Rhizoma Zingiberis Recens agent of claim 6, it is characterized in that: in add 7% sodium bicarbonate and 6% citric acid mixture be gas-producing disintegrant, the mixture that adds 3% sodium bicarbonate and 4% citric acid is a gas-producing disintegrant, and 1% magnesium stearate is a lubricant.
8. according to the preparation method of the described processed with Rhizoma Zingiberis Recens agent of claim 3, it is characterized in that: granule is preparation like this: with the Rhizoma Zingiberis Recens dregs powder, brown powdered sugar, the Sucus Zingberis powder mixes, and adds 1.5% lactose, adding the moistening back of ethanol granulates, make granule, or the bag film-coat, 50 ℃ of coating temperature, hydroxypropyl methylcellulose 60% dissolve with ethanol, promptly.
9. according to the preparation method of the described processed with Rhizoma Zingiberis Recens agent of claim 3, it is characterized in that: tablet is preparation like this: with the Rhizoma Zingiberis Recens dregs powder, and brown powdered sugar, the Sucus Zingberis powder mixes, and add the moistening back of ethanol and granulate, or granulate with the part Sucus Zingberis, drying, tabletting, promptly.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102224868A (en) * | 2011-05-11 | 2011-10-26 | 凤凰县果果三农科技发展有限公司 | Ginger tea solid beverage and preparation method thereof |
| CN102366062A (en) * | 2011-10-12 | 2012-03-07 | 兴义市东泰天然果蔬开发有限公司 | Ginger crystal and production technology thereof |
| CN102732409A (en) * | 2012-07-10 | 2012-10-17 | 迟玉森 | Aged yellow rice wine mate and method for preparing same |
| CN103549562A (en) * | 2013-09-13 | 2014-02-05 | 湖北凤头食品有限公司 | Instant ginger decoction powder and instant ginger decoction |
| CN105902986A (en) * | 2016-06-03 | 2016-08-31 | 河南省奥林特药业有限公司 | Preparation method of auxiliary material ginger juice for traditional Chinese medicine processing |
| CN106619559A (en) * | 2016-12-19 | 2017-05-10 | 沈阳化工大学 | Ginger aqueous extract freeze-dried powder effervescent tablet and preparation method thereof |
| CN106805165A (en) * | 2017-02-25 | 2017-06-09 | 石家庄以岭药业股份有限公司 | A kind of health food containing ginger powder and preparation method thereof |
| CN107410961A (en) * | 2017-05-21 | 2017-12-01 | 长汀县姜君农业发展有限公司 | A kind of ginger ball and preparation method thereof |
| CN107751877A (en) * | 2017-11-02 | 2018-03-06 | 灏ゅ浆 | A kind of preparation method of ginger ball |
| CN109043442A (en) * | 2018-08-26 | 2018-12-21 | 重庆海航农业开发有限公司 | A kind of instant ginger decoction |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102224868A (en) * | 2011-05-11 | 2011-10-26 | 凤凰县果果三农科技发展有限公司 | Ginger tea solid beverage and preparation method thereof |
| CN102366062A (en) * | 2011-10-12 | 2012-03-07 | 兴义市东泰天然果蔬开发有限公司 | Ginger crystal and production technology thereof |
| CN102732409A (en) * | 2012-07-10 | 2012-10-17 | 迟玉森 | Aged yellow rice wine mate and method for preparing same |
| CN103549562A (en) * | 2013-09-13 | 2014-02-05 | 湖北凤头食品有限公司 | Instant ginger decoction powder and instant ginger decoction |
| CN105902986A (en) * | 2016-06-03 | 2016-08-31 | 河南省奥林特药业有限公司 | Preparation method of auxiliary material ginger juice for traditional Chinese medicine processing |
| CN106619559A (en) * | 2016-12-19 | 2017-05-10 | 沈阳化工大学 | Ginger aqueous extract freeze-dried powder effervescent tablet and preparation method thereof |
| CN106805165A (en) * | 2017-02-25 | 2017-06-09 | 石家庄以岭药业股份有限公司 | A kind of health food containing ginger powder and preparation method thereof |
| CN107410961A (en) * | 2017-05-21 | 2017-12-01 | 长汀县姜君农业发展有限公司 | A kind of ginger ball and preparation method thereof |
| CN107751877A (en) * | 2017-11-02 | 2018-03-06 | 灏ゅ浆 | A kind of preparation method of ginger ball |
| CN109043442A (en) * | 2018-08-26 | 2018-12-21 | 重庆海航农业开发有限公司 | A kind of instant ginger decoction |
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