CN108969627A - A kind of novel reunion of bone drug and preparation method thereof - Google Patents
A kind of novel reunion of bone drug and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of novel reunion of bone drugs, including below according to the raw material of parts by weight: 40-60 parts of the rhizome of davallia, 30-50 parts of Mongolian oak fern, 30-40 parts of rhizoma dioscoreae nipponicae rhizome, 30-40 parts of Myriogyne minuta, 20-30 parts of purslane speedwell herb with root grass, 20-30 parts of vomiting nut, 10-20 parts of radix achyranthis bidentatae, 30-40 parts of muscone, 20-30 parts of lizard, 10-20 parts of mole cricket, 20-30 parts of ground bettle, the invention also discloses the preparation method of the novel reunion of bone drug, the present invention has good booster action for the patient after fracture operation.
Description
Technical field
The present invention relates to pharmaceutical technology field, specifically a kind of novel reunion of bone drug and preparation method thereof.
Background technique
While living in the world, inevitable birth and old age, sickness and death, the staff for being engaged in high risk industries is often injured, and injury has skin trauma,
Also have in as fracture, fracture needs to be engaged in bone-setting treatment within the hospital.It is perfect, scientific due to nowadays medical facilities
The development of technology and the promotion of medical level can treat big and small fracture illness, to fracture patient into
After row operative treatment, in the rehabilitation stage of patient, needs to take the various drugs for being conducive to bone growth, compare in the prior art
The drug taken after common fracture operation mainly has " reunion of bone piece ", muskiness bone-knitting capsules etc., these drugs are after taking
Effect be not comparatively it is very good, therefore, develop a kind of novel reunion of bone drug and aim at patients ' recovery after fracture operation
Taking seems most important.
Summary of the invention
It is mentioned above in the background art to solve the purpose of the present invention is to provide a kind of novel reunion of bone drug
Problem.
To achieve the above object, the invention provides the following technical scheme:
A kind of novel reunion of bone drug, including below according to the raw material of parts by weight: 40-60 parts of the rhizome of davallia, Mongolian oak fern 30-
50 parts, 30-40 parts of rhizoma dioscoreae nipponicae rhizome, 30-40 parts of Myriogyne minuta, 20-30 parts of purslane speedwell herb with root grass, 20-30 parts of vomiting nut, radix achyranthis bidentatae 10-
20 parts, 30-40 parts of muscone, 20-30 parts of lizard, 10-20 parts of mole cricket, 20-30 parts of ground bettle.
As a further solution of the present invention: including below according to the raw material of parts by weight: 45-55 parts of the rhizome of davallia, Mongolian oak fern 35-
45 parts, 32-38 parts of rhizoma dioscoreae nipponicae rhizome, 32-38 parts of Myriogyne minuta, 22-28 parts of purslane speedwell herb with root grass, 22-28 parts of vomiting nut, radix achyranthis bidentatae 12-
18 parts, 32-38 parts of muscone, 22-28 parts of lizard, 12-18 parts of mole cricket, 22-28 parts of ground bettle.
As further scheme of the invention: including below according to the raw material of parts by weight: 50 parts of the rhizome of davallia, Mongolian oak fern 40
Part, 35 parts of rhizoma dioscoreae nipponicae rhizome, 35 parts of Myriogyne minuta, purslane speedwell herb with root grass 25 parts, 25 parts of vomiting nut, 15 parts of radix achyranthis bidentatae, 35 parts of muscone,
25 parts of lizard, 15 parts of mole cricket, 25 parts of ground bettle.
As further scheme of the invention: the lizard is the Eremias argus of artificial feeding.
As further scheme of the invention: the lizard, mole cricket and ground bettle are dried with tile or casserole
The preparation method of the novel reunion of bone drug, steps are as follows:
1) lizard, mole cricket and ground bettle of formula ratio is taken to be placed in grinding container, be fully ground mix to granularity be 200-
300 mesh obtain powder A, spare；
2) powder A obtained in step 1) is placed in boiling container, the mixed solution that rice wine and deionized water is added steams
It boiling, digestion time is the good h of 1-2, and solution additive amount is 8-12 times of powder A inventory in parts by weight, after the completion of boiling
It is spare to cooking material B；Wherein, rice wine is Suzhou bridge sweet osmanthus rice dew moon seed-rice wine, the mass ratio of rice wine and deionized water in solution
For 1:1；
3) relative density is the medicinal extract C of 1.25-1.35 when cooking material B obtained in step 2) being concentrated into 50 DEG C, spare；
4) rhizome of davallia, Mongolian oak fern, rhizoma dioscoreae nipponicae rhizome, Myriogyne minuta, purslane speedwell herb with root grass, vomiting nut part, the radix achyranthis bidentatae of formula ratio is taken to set
In grinding container, it is fully ground the powder to granularity for 200-300 mesh, is powder D, it is spare；
5) powder D obtained in step 4) is placed in soaking container, water is added and impregnates 4, amount of water is that powder D feeds intake
10-12 times in parts by weight is measured, is filtered after the completion of impregnating, takes filtrate E, it is spare；
6) relative density is the medicinal extract F of 1.25-1.35 when filtrate E obtained in step 5) being concentrated into 50 DEG C, spare；
7) medicinal extract C will be obtained in medicinal extract F obtained in step 6) and step 3) uniformly to mix, being dried, crushed into partial size is
Acceptable auxiliary material in the prior art in pharmacy is added after 100-200 targeted fine powder, corresponding dosage form is made, have
Body can be pill, granule or capsule, obtain the novel reunion of bone drug of finished product.
The application of novel reunion of bone drug described above in pharmaceutical field.
Compared with prior art, the beneficial effects of the present invention are:
Novel reunion of bone drug prepared by the present invention is under the common mating reaction of various raw materials, after fracture operation
There is the special effect of auxiliary patients ' recovery in terms of the rehabilitation of patient, without side-effects, strong drug action of the invention is suitble to be widely used.
Specific embodiment
Below in conjunction with the embodiment of the present invention, technical scheme in the embodiment of the invention is clearly and completely described,
Obviously, described embodiments are only a part of the embodiments of the present invention, instead of all the embodiments.Based in the present invention
Embodiment, every other embodiment obtained by those of ordinary skill in the art without making creative efforts, all
Belong to the scope of protection of the invention.
Embodiment 1
A kind of novel reunion of bone drug, including below according to the raw material of parts by weight: 40 parts of the rhizome of davallia, 30 parts of Mongolian oak fern,
30 parts of rhizoma dioscoreae nipponicae rhizome, 30 parts of Myriogyne minuta, purslane speedwell herb with root careless 20 parts, 20 parts of vomiting nut, 10 parts of radix achyranthis bidentatae, 30 parts of muscone, lizard
20 parts of Yi, 10 parts of mole cricket, 20 parts of ground bettle；
Wherein, the lizard is the Eremias argus of artificial feeding, and the lizard, mole cricket and ground bettle use tile or casserole
It dries.
In the present embodiment, the preparation method of the novel reunion of bone drug, steps are as follows:
1) lizard, mole cricket and ground bettle of formula ratio is taken to be placed in grinding container, be fully ground mix to granularity be 200-
300 mesh obtain powder A, spare；
2) powder A obtained in step 1) is placed in boiling container, the mixed solution that rice wine and deionized water is added steams
It boils, digestion time 1.5h, solution additive amount is 12 times of powder A inventory in parts by weight, is steamed after the completion of boiling
Stewed Dish B, it is spare；Wherein, rice wine is Suzhou bridge sweet osmanthus rice dew moon seed-rice wine, and rice wine and the mass ratio of deionized water are 1 in solution:
1；
3) relative density is the medicinal extract C of 1.25-1.35 when cooking material B obtained in step 2) being concentrated into 50 DEG C, spare；
4) rhizome of davallia, Mongolian oak fern, rhizoma dioscoreae nipponicae rhizome, Myriogyne minuta, purslane speedwell herb with root grass, vomiting nut part, the radix achyranthis bidentatae of formula ratio is taken to set
In grinding container, it is fully ground the powder to granularity for 200-300 mesh, is powder D, it is spare；
5) powder D obtained in step 4) is placed in soaking container, water is added and impregnates 4, amount of water is that powder D feeds intake
10 times in parts by weight are measured, is filtered after the completion of impregnating, takes filtrate E, it is spare；
6) relative density is the medicinal extract F of 1.25-1.35 when filtrate E obtained in step 5) being concentrated into 50 DEG C, spare；
7) medicinal extract C will be obtained in medicinal extract F obtained in step 6) and step 3) uniformly to mix, being dried, crushed into partial size is
Acceptable auxiliary material in the prior art in pharmacy is added after 100-200 targeted fine powder, corresponding dosage form is made, have
Body can be pill, granule or capsule, obtain the novel reunion of bone drug of finished product.
Embodiment 2
A kind of novel reunion of bone drug, including below according to the raw material of parts by weight: 45 parts of the rhizome of davallia, 35 parts of Mongolian oak fern,
32 parts of rhizoma dioscoreae nipponicae rhizome, 32 parts of Myriogyne minuta, purslane speedwell herb with root careless 22 parts, 22 parts of vomiting nut, 12 parts of radix achyranthis bidentatae, 32 parts of muscone, lizard
22 parts of Yi, 12 parts of mole cricket, 22 parts of ground bettle；
Wherein, the lizard is the Eremias argus of artificial feeding, and the lizard, mole cricket and ground bettle use tile or casserole
It dries.
In the present embodiment, the preparation method of the novel reunion of bone drug, steps are as follows:
1) lizard, mole cricket and ground bettle of formula ratio is taken to be placed in grinding container, be fully ground mix to granularity be 200-
300 mesh obtain powder A, spare；
2) powder A obtained in step 1) is placed in boiling container, the mixed solution that rice wine and deionized water is added steams
It boils, digestion time 1.5h, solution additive amount is 12 times of powder A inventory in parts by weight, is steamed after the completion of boiling
Stewed Dish B, it is spare；Wherein, rice wine is Suzhou bridge sweet osmanthus rice dew moon seed-rice wine, and rice wine and the mass ratio of deionized water are 1 in solution:
1；
3) relative density is the medicinal extract C of 1.25-1.35 when cooking material B obtained in step 2) being concentrated into 50 DEG C, spare；
4) rhizome of davallia, Mongolian oak fern, rhizoma dioscoreae nipponicae rhizome, Myriogyne minuta, purslane speedwell herb with root grass, vomiting nut part, the radix achyranthis bidentatae of formula ratio is taken to set
In grinding container, it is fully ground the powder to granularity for 200-300 mesh, is powder D, it is spare；
5) powder D obtained in step 4) is placed in soaking container, water is added and impregnates 4, amount of water is that powder D feeds intake
10 times in parts by weight are measured, is filtered after the completion of impregnating, takes filtrate E, it is spare；
6) relative density is the medicinal extract F of 1.25-1.35 when filtrate E obtained in step 5) being concentrated into 50 DEG C, spare；
7) medicinal extract C will be obtained in medicinal extract F obtained in step 6) and step 3) uniformly to mix, being dried, crushed into partial size is
Acceptable auxiliary material in the prior art in pharmacy is added after 100-200 targeted fine powder, corresponding dosage form is made, have
Body can be pill, granule or capsule, obtain the novel reunion of bone drug of finished product.
Embodiment 3
A kind of novel reunion of bone drug, including below according to the raw material of parts by weight: 50 parts of the rhizome of davallia, 40 parts of Mongolian oak fern,
35 parts of rhizoma dioscoreae nipponicae rhizome, 35 parts of Myriogyne minuta, purslane speedwell herb with root careless 25 parts, 25 parts of vomiting nut, 15 parts of radix achyranthis bidentatae, 35 parts of muscone, lizard
25 parts of Yi, 15 parts of mole cricket, 25 parts of ground bettle；
Wherein, the lizard is the Eremias argus of artificial feeding, and the lizard, mole cricket and ground bettle use tile or casserole
It dries.
In the present embodiment, the preparation method of the novel reunion of bone drug, steps are as follows:
1) lizard, mole cricket and ground bettle of formula ratio is taken to be placed in grinding container, be fully ground mix to granularity be 200-
300 mesh obtain powder A, spare；
2) powder A obtained in step 1) is placed in boiling container, the mixed solution that rice wine and deionized water is added steams
It boils, digestion time 1.5h, solution additive amount is 12 times of powder A inventory in parts by weight, is steamed after the completion of boiling
Stewed Dish B, it is spare；Wherein, rice wine is Suzhou bridge sweet osmanthus rice dew moon seed-rice wine, and rice wine and the mass ratio of deionized water are 1 in solution:
1；
3) relative density is the medicinal extract C of 1.25-1.35 when cooking material B obtained in step 2) being concentrated into 50 DEG C, spare；
4) rhizome of davallia, Mongolian oak fern, rhizoma dioscoreae nipponicae rhizome, Myriogyne minuta, purslane speedwell herb with root grass, vomiting nut part, the radix achyranthis bidentatae of formula ratio is taken to set
In grinding container, it is fully ground the powder to granularity for 200-300 mesh, is powder D, it is spare；
5) powder D obtained in step 4) is placed in soaking container, water is added and impregnates 4, amount of water is that powder D feeds intake
10 times in parts by weight are measured, is filtered after the completion of impregnating, takes filtrate E, it is spare；
6) relative density is the medicinal extract F of 1.25-1.35 when filtrate E obtained in step 5) being concentrated into 50 DEG C, spare；
7) medicinal extract C will be obtained in medicinal extract F obtained in step 6) and step 3) uniformly to mix, being dried, crushed into partial size is
Acceptable auxiliary material in the prior art in pharmacy is added after 100-200 targeted fine powder, corresponding dosage form is made, have
Body can be pill, granule or capsule, obtain the novel reunion of bone drug of finished product.
Embodiment 4
A kind of novel reunion of bone drug, including below according to the raw material of parts by weight: 55 parts of the rhizome of davallia, 45 parts of Mongolian oak fern,
38 parts of rhizoma dioscoreae nipponicae rhizome, 38 parts of Myriogyne minuta, purslane speedwell herb with root careless 28 parts, 28 parts of vomiting nut, 18 parts of radix achyranthis bidentatae, 38 parts of muscone, lizard
28 parts of Yi, 18 parts of mole cricket, 28 parts of ground bettle；
Wherein, the lizard is the Eremias argus of artificial feeding, and the lizard, mole cricket and ground bettle use tile or casserole
It dries.
In the present embodiment, the preparation method of the novel reunion of bone drug, steps are as follows:
1) lizard, mole cricket and ground bettle of formula ratio is taken to be placed in grinding container, be fully ground mix to granularity be 200-
300 mesh obtain powder A, spare；
2) powder A obtained in step 1) is placed in boiling container, the mixed solution that rice wine and deionized water is added steams
It boils, digestion time 1.5h, solution additive amount is 12 times of powder A inventory in parts by weight, is steamed after the completion of boiling
Stewed Dish B, it is spare；Wherein, rice wine is Suzhou bridge sweet osmanthus rice dew moon seed-rice wine, and rice wine and the mass ratio of deionized water are 1 in solution:
1；
3) relative density is the medicinal extract C of 1.25-1.35 when cooking material B obtained in step 2) being concentrated into 50 DEG C, spare；
4) rhizome of davallia, Mongolian oak fern, rhizoma dioscoreae nipponicae rhizome, Myriogyne minuta, purslane speedwell herb with root grass, vomiting nut part, the radix achyranthis bidentatae of formula ratio is taken to set
In grinding container, it is fully ground the powder to granularity for 200-300 mesh, is powder D, it is spare；
5) powder D obtained in step 4) is placed in soaking container, water is added and impregnates 4, amount of water is that powder D feeds intake
10 times in parts by weight are measured, is filtered after the completion of impregnating, takes filtrate E, it is spare；
6) relative density is the medicinal extract F of 1.25-1.35 when filtrate E obtained in step 5) being concentrated into 50 DEG C, spare；
7) medicinal extract C will be obtained in medicinal extract F obtained in step 6) and step 3) uniformly to mix, being dried, crushed into partial size is
Acceptable auxiliary material in the prior art in pharmacy is added after 100-200 targeted fine powder, corresponding dosage form is made, have
Body can be pill, granule or capsule, obtain the novel reunion of bone drug of finished product.
Embodiment 5
A kind of novel reunion of bone drug, including below according to the raw material of parts by weight: 60 parts of the rhizome of davallia, -50 parts of Mongolian oak fern,
40 parts of rhizoma dioscoreae nipponicae rhizome, 40 parts of Myriogyne minuta, purslane speedwell herb with root careless 30 parts, 30 parts of vomiting nut, 20 parts of radix achyranthis bidentatae, 40 parts of muscone, lizard
30 parts of Yi, 20 parts of mole cricket, 30 parts of ground bettle；
Wherein, the lizard is the Eremias argus of artificial feeding, and the lizard, mole cricket and ground bettle use tile or casserole
It dries.
In the present embodiment, the preparation method of the novel reunion of bone drug, steps are as follows:
1) lizard, mole cricket and ground bettle of formula ratio is taken to be placed in grinding container, be fully ground mix to granularity be 200-
300 mesh obtain powder A, spare；
2) powder A obtained in step 1) is placed in boiling container, the mixed solution that rice wine and deionized water is added steams
It boils, digestion time 1.5h, solution additive amount is 12 times of powder A inventory in parts by weight, is steamed after the completion of boiling
Stewed Dish B, it is spare；Wherein, rice wine is Suzhou bridge sweet osmanthus rice dew moon seed-rice wine, and rice wine and the mass ratio of deionized water are 1 in solution:
1；
3) relative density is the medicinal extract C of 1.25-1.35 when cooking material B obtained in step 2) being concentrated into 50 DEG C, spare；
4) rhizome of davallia, Mongolian oak fern, rhizoma dioscoreae nipponicae rhizome, Myriogyne minuta, purslane speedwell herb with root grass, vomiting nut part, the radix achyranthis bidentatae of formula ratio is taken to set
In grinding container, it is fully ground the powder to granularity for 200-300 mesh, is powder D, it is spare；
5) powder D obtained in step 4) is placed in soaking container, water is added and impregnates 4, amount of water is that powder D feeds intake
10 times in parts by weight are measured, is filtered after the completion of impregnating, takes filtrate E, it is spare；
6) relative density is the medicinal extract F of 1.25-1.35 when filtrate E obtained in step 5) being concentrated into 50 DEG C, spare；
7) medicinal extract C will be obtained in medicinal extract F obtained in step 6) and step 3) uniformly to mix, being dried, crushed into partial size is
Acceptable auxiliary material in the prior art in pharmacy is added after 100-200 targeted fine powder, corresponding dosage form is made, have
Body can be pill, granule or capsule, obtain the novel reunion of bone drug of finished product.
Comparative example 1
Compared with Example 3, Mongolian oak fern is free of, other are same as Example 3.
Comparative example 2
Compared with Example 3, without purslane speedwell herb with root grass, other are same as Example 3.
Comparative example 3
Compared with Example 3, without Mongolian oak fern and purslane speedwell herb with root grass, other are same as Example 3.
Curative effect test, test result are carried out to reunion of bone drug novel prepared by embodiment 1-5 and comparative example 1-3
As shown in table 1.
Table 1
From result above as can be seen that embodiment 3 be most preferred embodiment, joined Mongolian oak fern and purslane speedwell herb with root grass it is novel
Reunion of bone drug have clear improvement for the rehabilitation effect of the patient after fracture operation.
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie
In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter
From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power
Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims
Variation is included within the present invention.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (7)
1. a kind of novel reunion of bone drug, which is characterized in that including below according to the raw material of parts by weight: rhizome of davallia 40-60
Part, 30-50 parts of Mongolian oak fern, 30-40 parts of rhizoma dioscoreae nipponicae rhizome, 30-40 parts of Myriogyne minuta, 20-30 parts of purslane speedwell herb with root grass, vomiting nut 20-30
Part, 10-20 parts of radix achyranthis bidentatae, 30-40 parts of muscone, 20-30 parts of lizard, 10-20 parts of mole cricket, 20-30 parts of ground bettle.
2. novel reunion of bone drug according to claim 1, which is characterized in that including below according to the original of parts by weight
Material: 45-55 parts of the rhizome of davallia, 35-45 parts of Mongolian oak fern, 32-38 parts of rhizoma dioscoreae nipponicae rhizome, 32-38 parts of Myriogyne minuta, purslane speedwell herb with root grass 22-28
Part, 22-28 parts of vomiting nut, 12-18 parts of radix achyranthis bidentatae, 32-38 parts of muscone, 22-28 parts of lizard, 12-18 parts of mole cricket, ground bettle
22-28 parts.
3. novel reunion of bone drug according to claim 2, which is characterized in that including below according to the original of parts by weight
Material: 50 parts of the rhizome of davallia, 40 parts of Mongolian oak fern, 35 parts of rhizoma dioscoreae nipponicae rhizome, 35 parts of Myriogyne minuta, purslane speedwell herb with root careless 25 parts, 25 parts of vomiting nut, ox
15 parts of knee, 35 parts of muscone, 25 parts of lizard, 15 parts of mole cricket, 25 parts of ground bettle.
4. novel reunion of bone drug according to claim 1 to 3, which is characterized in that the lizard is artificial raises
Feeding Eremias argus.
5. novel reunion of bone drug according to claim 4, which is characterized in that the lizard, mole cricket and ground bettle
Dried with tile or casserole.
6. a kind of preparation method of novel reunion of bone drug a method according to any one of claims 1-3, which is characterized in that including
Following steps:
1) lizard, mole cricket and ground bettle of formula ratio is taken to be placed in grinding container, be fully ground mix to granularity be 200-300
Mesh obtains powder A, spare；
2) powder A obtained in step 1) is placed in boiling container, the mixed solution boiling of rice wine and deionized water is added, steamed
Boiling the time is the good h of 1-2, and solution additive amount is 8-12 times of powder A inventory in parts by weight, and boiling is obtained after the completion of boiling
Object B, it is spare；Wherein, rice wine is Suzhou bridge sweet osmanthus rice dew moon seed-rice wine, and rice wine and the mass ratio of deionized water are 1:1 in solution；
3) relative density is the medicinal extract C of 1.25-1.35 when cooking material B obtained in step 2 being concentrated into 50 DEG C, spare；
4) rhizome of davallia, Mongolian oak fern, rhizoma dioscoreae nipponicae rhizome, Myriogyne minuta, purslane speedwell herb with root grass, vomiting nut part, the radix achyranthis bidentatae of formula ratio is taken to be placed in and grind
It grinds in container, is fully ground the powder to granularity for 200-300 mesh, be powder D, it is spare；
5) powder D obtained in step 4) is placed in soaking container, water is added and impregnates 4, amount of water is that powder D inventory is pressed
According to 10-12 times of parts by weight meter, is filtered after the completion of impregnating, take filtrate E, it is spare；
6) relative density is the medicinal extract F of 1.25-1.35 when filtrate E obtained in step 5) being concentrated into 50 DEG C, spare；
7) medicinal extract C will be obtained in medicinal extract F obtained in step 6) and step 3) uniformly to mix, being dried, crushed into partial size is 100-
Acceptable auxiliary material in the prior art in pharmacy is added after 200 targeted fine powders, corresponding dosage form is made, specifically may be used
To be pill, granule or capsule, the novel reunion of bone drug of finished product is obtained.
7. a kind of application of novel reunion of bone drug a method according to any one of claims 1-3 in pharmaceutical field.
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| CN1454657A (en) * | 2003-03-27 | 2003-11-12 | 张东海 | Bone-setting powdered medicine composition |
| CN1723959A (en) * | 2005-07-13 | 2006-01-25 | 王志敏 | Method for preparing medicine for treating cataclasis and soft tissue injury |
| CN101129670A (en) * | 2007-09-12 | 2008-02-27 | 郭思海 | Chinese medicine composition for curing fracture |
| CN104491302A (en) * | 2014-12-02 | 2015-04-08 | 黑龙江江恒医药科技有限公司 | Bone-reunion capsules and preparation method thereof |
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