CN1215869C - Black-bone chicken white phoenix preparation medicine and its preparing method - Google Patents
Black-bone chicken white phoenix preparation medicine and its preparing method Download PDFInfo
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Abstract
The present invention discloses a black-bone chicken white phoenix preparation medicine used for benefiting qi for nourishing blood, regulating menstruation for arresting hemorrhage and curing qi-blood deficiency, physical emaciation, waist and knee soreness and softness, menstrual disorder, metrorrhagia and leukorrhea, etc., and a preparing method thereof. The black-bone chicken white phoenix preparation medicine contains black-bone chicken (hair, pawl and intestine removal), red sage root, calcined oyster, deglued antler, astragalus root, turtle shell, nutgrass galingale rhizome (processed with vinegar), ginseng, rehmannia root, white peony alba, starwort root, licorice root, gordon euryale seed, hemlock parsley, deerhorn glue, common yam rhizome, mantis egg-case, angelica, radix asparagi and prepared rehmannia root and the raw materials are prepared into concentrated pills, mini-pills, granules, tablets, soft extracts, syrup, mixture, dripping pills and capsules by a macroporous resin separation technique, an enzymolysis technique, etc. The present invention has the advantages of effective component content control, high medicine biological availability, curative effect guarantee, small dosage and convenient oral application.
Description
Technical field
The present invention relates to a kind of benefiting qi and nourishing blood, regulating menstruation, hemostasis, cure mainly QI and blood deficiency, asthenic body, soreness of the waist and knees, menoxenia, the WUJI BAIFENG preparation medicine of diseases such as bleeding not during menses the invention still further relates to the method for this medication preparation.
Technical background
WUJI BAIFENG WAN is a kind of classical Chinese patent medicine, and this product has benefiting qi and nourishing blood, and the function of regulating menstruation, hemostasis is used for QI and blood deficiency, asthenic body, soreness of the waist and knees, menoxenia, diseases such as bleeding not during menses.The medicine that has said function at present generally adopts honeyed pill, water-honeyed pill dosage form, and existing dosage form exists honeyed pill big with the honey amount, the easy moisture absorption, mouldy, rotten, and patient's taking dose is big, and bioavailability is not high, shortcomings such as slow curative effect.
Summary of the invention
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully, and curative effect is guaranteed, the preparation method of the WUJI BAIFENG preparation medicine that dose significantly reduces.
To achieve these goals, the present invention takes following technical scheme:
It is the medicament of being made by the raw material of following constituent content percentage ratio (its content percent) for a medicine of the present invention:
Gallus Domesticus (removing feather claw and intestine) 10%-28% Radix Salviae Miltiorrhizae 4%-6%
Concha Ostreae (forging) 1%-2% Cornu Cervi Degelatinatum 1%-2%
Radix Astragali 1%-1.3% Carapax Trionycis (system) 2%-3%
Rhizoma Cyperi (vinegar system) 4%-6% Radix Ginseng 4%-6%
Radix Rehmanniae 8%-11% Radix Paeoniae Alba 4%-6%
Radix Stellariae 1%-2% Radix Glycyrrhizae 1%-2%
Semen Euryales (stir-fry) 1%-3% Rhizoma Chuanxiong 2%-3%
Colla cornus cervi 4%-6% Rhizoma Dioscoreae 4%-6%
Ootheca Mantidis 1%-2% Radix Angelicae Sinensis 4%-6%
Radix Asparagi 2%-3% Radix Rehmanniae Preparata 8%-11%
The medicament that medicine of the present invention is made by the raw material of following constituent content optimized percentage (its content percent):
Gallus Domesticus (removing feather claw and intestine) 25.08% Radix Salviae Miltiorrhizae 5.01%
Concha Ostreae (forging) 1.86% Cornu Cervi Degelatinatum 1.86%
The Radix Astragali 1.25% Carapax Trionycis (system) 2.51%
Rhizoma Cyperi (vinegar system) 5.01% Radix Ginseng 5.01%
Radix Rehmanniae 10.03% Radix Paeoniae Alba 5.01%
Radix Stellariae 1.02% Radix Glycyrrhizae 1.25%
Semen Euryales (stir-fry) 2.51% Rhizoma Chuanxiong 2.51%
Colla cornus cervi 5.01% Rhizoma Dioscoreae 5.01%
Ootheca Mantidis 1.86% Radix Angelicae Sinensis 5.66%
Radix Asparagi 2.51% Radix Rehmanniae Preparata 10.03%
Technical scheme of the present invention is based on modern material and pharmacy novel technique.This technology has mainly adopted macroporous adsorbent resin isolation technics, zymolysis technique, and method for making is:
1, above 20 flavors are got Gallus Domesticus and are cut into piece, add 2-5 times of water gaging, boiled 0.5-4 hour, (5-15: 1) defat adds papain (40-500: 1) stir afterwards to use hard paraffin while hot, regulate pH value to 4-8,40 ℃-65 ℃ after hydrolysis 2-8 hour, boiled 2-20 minute, centrifugal, supernatant is evaporated to thick paste, relative density 1.02-1.32 (60 ℃), (T50-100 ℃ of vacuum drying, P-0.02-0.12MPa), get dry extract, standby.
2, get Carapax Trionycis, decoct with water secondary, add water 2-5 doubly at every turn, boiled 0.5-4 hour, filter, merging filtrate is evaporated to thick paste, relative density 1.02-1.32 (60 ℃), vacuum drying (T50-100 ℃, P-0.02-0.12MPa), get dry extract, standby.
3, get broken Radix Ginseng, the Radix Paeoniae Alba, Radix Asparagi, Radix Glycyrrhizae decocts with water secondary, add water 2-8 doubly at every turn, boiled 0.5-3 hour, filter merging filtrate, filtrate or filtrate decompression is concentrated to relative density is 1.02-1.20 (50 ℃), add macroporous adsorptive resins (every gram medical material of having handled well, restrain resin with 0.5-4) on, with 3-10 times of water gaging eluting, discard water lotion, reuse 50%-95% ethanol elution, do not have saponin reaction to the eluent inspection, the eluent decompression recycling ethanol is to thick paste, relative density 1.02-1.34 (60 ℃), (T50-100 ℃ of vacuum drying, P-0.02-0.12MPa), get dry extract, standby.
4, get broken Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the Radix Astragali, Ootheca Mantidis and Radix Stellariae, add 60%-80% ethanol, the reflux, extract, secondary, add ethanol 2-8 doubly measures at every turn, backflow 0.5-3 hour, filter merging filtrate, decompression recycling ethanol is to thick paste, relative density 1.02-1.32 (60 ℃), and vacuum drying (T50-100 ℃, P-0.02-0.12MPa), get dry extract, standby.
5, get broken Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Euryales, Cornu Cervi Degelatinatum, Concha Ostreae and decoct with water secondary, add water 6-10 doubly at every turn, boiled 0.5-4 hour, filter, merging filtrate, being evaporated to relative density is the thick paste of 1.02-1.35 (60 ℃), adds 75%-90% ethanol and stirs, make the alcohol amount of containing be 50%-70%, standing over night is got supernatant, filters, decompression recycling ethanol is to thick paste, relative density 1.02-1.32 (60 ℃), and vacuum drying (T50-100 ℃, P-0.02-0.12MPa), get dry extract, standby.
6, get Rhizoma Cyperi and add 4-8 times of water gaging, be heated to and boil, extract volatile oil till the oily defecation, volatile oil is standby.
7, get Rhizoma Dioscoreae, Colla cornus cervi, pulverize separately becomes fine powder (crossing 100 mesh sieves), and is standby.
8, with each dry extract of above-mentioned gained, fine powder, adjuvant 2.1%-18% mixed powder are broken into fine powder (crossing 100 mesh sieves), granulate, and sieve.Spray into Rhizoma Cyperi volatile oil, mixing,
9, above-mentioned gained is prepared in described ratio, make solid preparation (as tablet, soft capsule, capsule, granule, slow releasing tablet, drop pill etc.), liquid preparation (as syrup, mixture etc.) according to rules of preparations of Chinese Pharmacopoeia version in 2000.
A kind of key character of the present invention is to adopt zymolysis technique, and animal proteinum is resolved into the aminoacid that human body easily absorbs, and has improved effective ingredient; Utilize the macroporous adsorbent resin isolation technics, effectively extract active component, further remove invalid components, dwindled dose, facilitate patients.More than two The Application of Technology greatly improved bioavailability and guaranteed curative effect.The Wuji Baifen pian of the present invention's preparation is used for QI and blood deficiency, asthenic body, and soreness of the waist and knees, menoxenia, diseases such as bleeding not during menses are evident in efficacy, and this content is seen Wuji Baifen pian II phase clinical experiment final report (attached), through 100 routine patients are carried out clinical observation.The clinical efficacy of proof Wuji Baifen pian is remarkable, and the effect of its benefiting QI and nourishing blood is obvious, to both Qi and blood deficiency menoxenia, asthenic body, soreness of the waist and knees, diseases such as bleeding not during menses have significant curative effect, and safe and reliable, do not find toxic and side effects, taking convenience is easy to carry, and is easily accepted by the patient.
The present invention also provides solid preparation (as tablet, soft capsule, capsule, granule, slow releasing tablet, drop pill etc.), the liquid preparation (as syrup, mixture etc.) of WUJI BAIFENG preparation medicine.
Description of drawings
Fig. 1 is Wuji Baifen pian technological process of production figure.
Fig. 2 is WUJI BAIFENG granule technological process of production figure.
Fig. 3 is a WUJI BAIFENG capsule manufacture process chart.
Fig. 4 is WUJI BAIFENG concentrated pill technological process of production figure.
Fig. 5 is Wujibaifeng soft capsule technological process of production figure.
Fig. 6 is dripping pills made from black-bone chicken technological process of production figure.
The specific embodiment
As follows according to preparation method embodiment of the present invention (with best proportioning):
Embodiment 1: Fig. 1 is Wuji Baifen pian technological process of production figure, preparation sheet agent method:
1, goes out finished product 1000 tablet recipes
Gallus Domesticus (removing feather claw and intestine) 540g Radix Salviae Miltiorrhizae 108g
Concha Ostreae (forging) 40g Cornu Cervi Degelatinatum 40g
Radix Astragali 27g Carapax Trionycis (system) 54g
Rhizoma Cyperi (vinegar system) 108g Radix Ginseng 108g
Radix Rehmanniae 216g Radix Paeoniae Alba 108g
Radix Stellariae 22g Radix Glycyrrhizae 27g
Semen Euryales (stir-fry) 54g Rhizoma Chuanxiong 54g
Colla cornus cervi 108g Rhizoma Dioscoreae 108g
Ootheca Mantidis 40g Radix Angelicae Sinensis 122g
Radix Asparagi 54g Radix Rehmanniae Preparata 216g
2, adjuvant: microcrystalline Cellulose 2%-10%, the 3%-5% of Opadry substrate weight etc.
3, preparation method:
(1) above 20 flavors are got Gallus Domesticus and are cut into piece, add 2-5 times of water gaging, boiled 0.5-4 hour, (5-15: 1) defat adds papain (40-500: 1) stir afterwards to use hard paraffin while hot, regulate pH value to 4-8,40 ℃-65 ℃ after hydrolysis 2-8 hour, boiled 2-20 minute, centrifugal, supernatant is evaporated to thick paste, relative density 1.02-1.32 (60 ℃), (T50-100 ℃ of vacuum drying, P-0.02-0.12MPa), get dry extract, standby.
(2) get Carapax Trionycis, decoct with water secondary, add water 2-5 doubly at every turn, boiled 0.5-4 hour, filter, merging filtrate is evaporated to thick paste, relative density 1.02-1.32 (60 ℃), vacuum drying (T50-100 ℃, P-0.02-0.12MPa), get dry extract, standby.
Get Carapax Trionycis, decoct with water secondary, add water 2-5 doubly at every turn, boiled 0.5-4 hour, filter, merging filtrate is evaporated to thick paste, relative density 1.02-1.32 (60 ℃), vacuum drying (T50-100 ℃, P-0.02-0.12MPa), get dry extract, standby.
(3) get broken Radix Ginseng, the Radix Paeoniae Alba, Radix Asparagi, Radix Glycyrrhizae decocts with water secondary, add water 2-8 doubly at every turn, boiled 0.5-3 hour, filter, merging filtrate, filtrate or filtrate decompression is concentrated to relative density is 1.02-1.20 (50 ℃) adds on the macroporous adsorptive resins of having handled well, with 3-10 times of water gaging eluting, discard water lotion, reuse 50%-95% ethanol elution does not have saponin to the eluent inspection and reacts, the eluent decompression recycling ethanol is to thick paste, relative density 1.02-1.34 (60 ℃), and vacuum drying (T50-100 ℃, P-0.02-0.12MPa), get dry extract, standby.
(4) get broken Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the Radix Astragali, Ootheca Mantidis and Radix Stellariae, add .60%-80% ethanol, the reflux, extract, secondary, add ethanol 2-8 doubly measures at every turn, backflow 0.5-3 hour, filter merging filtrate, decompression recycling ethanol is to thick paste, relative density 1.02-1.32 (60 ℃), and vacuum drying (T50-100 ℃, P-0.02-0.12MPa), get dry extract, standby.
(5) get broken Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Euryales, Cornu Cervi Degelatinatum, Concha Ostreae and decoct with water secondary, add water 6-10 doubly at every turn, boiled 0.5-4 hour, filter, merging filtrate, being evaporated to relative density is the thick paste of 1.02-1.35 (60 ℃), adds 75%-90% ethanol and stirs, make the alcohol amount of containing be 50%-70%, standing over night is got supernatant, filters, decompression recycling ethanol is to thick paste, relative density 1.02-1.32 (60 ℃), and vacuum drying (T50-100 ℃, P-0.02-0.12MPa), get dry extract, standby.
(6) get Rhizoma Cyperi and add 4-8 times of water gaging, be heated to and boil, extract volatile oil till the oily defecation, volatile oil is standby.
(7) get Rhizoma Dioscoreae, Colla cornus cervi, pulverize separately becomes fine powder (crossing 100 mesh sieves), and is standby.
(8), with each dry extract 44.34%-59.60% of above-mentioned gained, fine powder 34.56%-42.77%, microcrystalline Cellulose 2%-10% mixed powder are broken into fine powder (cross 100 mesh sieves), granulate, and sieve.Spray into Rhizoma Cyperi volatile oil 0.06%-0.22%, mixing adds lubricant 0.1%-1% mixing, is pressed into 1000, and bag film-coat 3%-5% promptly gets Wuji Baifen pian, every heavy 0.5g, and every contains crude drug amount 2.1-2.2g; Usage and consumption: oral, one time 2,2 times on the one; Function with cure mainly: benefiting qi and nourishing blood, adjusting meridian and stopping leukorrhea.Be used for QI and blood deficiency, asthenic body, soreness of the waist and knees, menoxenia, diseases such as bleeding not during menses, curative effect is as mentioned above.
Embodiment 2: Fig. 2 is WUJI BAIFENG granule technological process of production figure.Preparation granule method:
1, prescription (same tablet).
2, preparation method:
(1) to (7) same tablet
(8) each dry extract of above-mentioned gained, fine powder are added proper auxiliary materials (diluent, correctives: as lactose, sucrose, mannitol, sorbitol, starch, microcrystalline Cellulose etc.), pulverize, make granule; Or make granule with other method (as one-step palletizing, boiling granulating etc.), and spraying into Rhizoma Cyperi volatile oil, the mixing that sieves promptly gets the WUJI BAIFENG granule.
Embodiment 3: Fig. 3 is WUJI BAIFENG hard capsule technological process of production figure, preparation hard capsule method:
1, prescription (same tablet)
2, preparation method:
(1) to (9) same tablet
(10) incapsulate, promptly get the WUJI BAIFENG hard capsule.
Embodiment 4: Fig. 4 is WUJI BAIFENG concentrated pill technological process of production figure, preparation concentrated pill method:
1, prescription (same tablet)
2, preparation method:
(1) to (7) same tablet
(8) each dry extract of above-mentioned gained, fine powder mixed powder are broken into fine powder, sieve.
(9) spray into Rhizoma Cyperi volatile oil, mixing.
(10) add proper honey and water, pill, the bag film-coat promptly gets the WUJI BAIFENG concentrated pill.
Embodiment 5: Fig. 5 is Wujibaifeng soft capsule technological process of production figure, preparation soft capsule method:
1, prescription (same tablet)
2, preparation method:
(1) gets Gallus Domesticus and be cut into piece, add 2-5 times of water gaging, boiled 0.5-4 hour, use the hard paraffin defat while hot, add papain (40-500: 1) stir, regulate pH value afterwards to 4-8,40 ℃-65 ℃ were boiled 2-20 minute after hydrolysis 2-8 hour, centrifugal, the supernatant concentrating under reduced pressure becomes concentrated solution relative density 1.02-1.32 (60 ℃), and is standby.
(2) get Carapax Trionycis, decoct with water secondary, add water 2-5 for the first time doubly, boiled 0.5-4 hour, filter, merging filtrate, concentrating under reduced pressure become concentrated solution relative density 1.02-1.32 (60 ℃), and be standby.
(3) get broken Radix Ginseng, the Radix Paeoniae Alba, Radix Asparagi, Radix Glycyrrhizae and decoct with water secondary, add water 2-8 doubly at every turn, boiled 0.5-3 hour, filter, merging filtrate, filtrate or filtrate decompression is concentrated to relative density is 1.02-1.20 (50 ℃), add on the macroporous adsorptive resins of having handled well (every gram medical material restrains resin with 0.5-4), with 3-10 times of water gaging eluting, discard water lotion, reuse 50%-95% ethanol elution does not have the saponin reaction to the eluent inspection, and the eluent decompression recycling ethanol becomes concentrated solution, relative density 1.02-1.34 (60 ℃), standby.
(4) get broken Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the Radix Astragali, Ootheca Mantidis and Radix Stellariae, add 60%-80% ethanol, the reflux, extract, secondary, add ethanol 2-8 at every turn and doubly measure, backflow 0.5-3 hour, filter, merging filtrate, decompression recycling ethanol becomes concentrated solution, and relative density 1.02-1.32 (60 ℃) is standby.
(5) get broken Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Euryales, Cornu Cervi Degelatinatum, Concha Ostreae and decoct with water secondary, add water 6-10 doubly at every turn, boiled 0.5-4 hour, filter, merging filtrate, being evaporated to relative density is the thick paste of 1.02-1.35 (60 ℃), adds 75%-90% ethanol and stirs, make the alcohol amount of containing be 50%-70%, standing over night is got supernatant, filters, decompression recycling ethanol becomes concentrated solution relative density 1.02-1.32 (60 ℃), and is standby.
(6) get Rhizoma Cyperi and add 4-8 times of water gaging, be heated to and boil, extract volatile oil till the oily defecation, volatile oil is standby.
(7) get Rhizoma Dioscoreae, Colla cornus cervi, pulverize separately becomes fine powder (crossing 100 mesh sieves), and is standby.
(8) concentrated solution, fine powder, the volatile oil with above-mentioned gained is mixed into suspension.
(9) system softgel shell: 10 parts in gelatin, glycerol 3.2 0-3.35 parts (weight ratio) add suitable quantity of water with gelatin and dissolve the back fully and add glycerol and stir evacuation, degassing back insulation set aside for use.
(10) suspension is added diluent 20%-600%, antioxidant 0.5%-5%, suspending agent 0.1%-5% etc., stir, room temperature leaves standstill, and presses soft capsule promptly to get Wujibaifeng soft capsule.
Embodiment 6: Fig. 6 is dripping pills made from black-bone chicken technological process of production figure, preparation drop pill method:
1, prescription (same tablet)
2, preparation method:
(1) gets Gallus Domesticus and be cut into piece, add 2-5 times of water gaging, boiled 0.5-4 hour, and used the hard paraffin defat while hot, add papain (40-500: 1) stir afterwards, regulate pH value to 4-8,40 ℃-65 ℃ after hydrolysis 2-8 hour, boil 2 minutes-20 minutes, centrifugal, the supernatant concentrating under reduced pressure becomes concentrated solution relative density 1.02-1.32 (60 ℃), and is standby.
(2) get Carapax Trionycis, decoct with water secondary, add water 2-5 doubly at every turn, boiled 0.5-4 hour, filter, merging filtrate, concentrating under reduced pressure become concentrated solution relative density 1.02-1.32 (60 ℃), and be standby.
(3) get broken Radix Ginseng, the Radix Paeoniae Alba, Radix Asparagi, Radix Glycyrrhizae and decoct with water secondary, add water 2-8 doubly at every turn, boiled 0.5-3 hour, filter, merging filtrate, filtrate or filtrate decompression is concentrated to relative density is 1.02-1.20 (50 ℃), add on the macroporous adsorptive resins of having handled well, with 3-10 times of water gaging eluting, discard water lotion, reuse 50%-95% ethanol elution, not having saponin to the eluent inspection reacts, the eluent decompression recycling ethanol becomes concentrated solution, and relative density 1.02-1.34 (60 ℃) is standby.
(4) get broken Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the Radix Astragali, Ootheca Mantidis and Radix Stellariae, add 60%-80% ethanol, the reflux, extract, secondary, add ethanol 2-8 at every turn and doubly measure, backflow 0.5-3 hour, filter, merging filtrate, decompression recycling ethanol becomes concentrated solution, and relative density 1.02-1.32 (60 ℃) is standby.
(5) get broken Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Euryales, Cornu Cervi Degelatinatum, Concha Ostreae and decoct with water secondary, add water 6-10 doubly at every turn, boiled 0.5-4 hour, filter, merging filtrate, being evaporated to relative density is the thick paste of 1.02-1.35 (60 ℃), adds 75%-90% ethanol and stirs, make the alcohol amount of containing be 50%-70%, standing over night is got supernatant, filters, decompression recycling ethanol becomes concentrated solution relative density 1.02-1.32 (60 ℃), and is standby.
(6) get Rhizoma Cyperi and add 4-8 times of water gaging, be heated to and boil, extract volatile oil till the oily defecation, volatile oil is standby.
(7) get Rhizoma Dioscoreae, Colla cornus cervi, pulverize separately becomes fine powder (crossing 100 mesh sieves), and is standby.
(8) concentrated solution, fine powder, the volatile oil with above-mentioned gained is mixed into suspension.
(9) with above-mentioned suspension and substrate stearic acid or sodium stearate or glycerol or Polyethylene Glycol or Lac, by 1: (1-18) mixing, splash in arbitrary condensing agents such as vegetable oil, methyl-silicone oil, ethanol, liquid paraffin at 50 ℃-100 ℃ and to make drop pill, natural drying promptly gets dripping pills made from black-bone chicken.
Claims (2)
1. preparation method for the treatment of QI and blood deficiency, menoxenia and bleeding not during menses medicine, its feature comprises the steps:
(1) prepare raw material:
The Gallus Domesticus 540g Radix Salviae Miltiorrhizae 108g of removing feather claw and intestine
Concha Ostreae (calcined) 40g Cornu Cervi Degelatinatum 40g
Radix Astragali 27g Carapax Trionycis (processed) 54g
Rhizoma Cyperi (processed with vinegar) 108g Radix Ginseng 108g
Radix Rehmanniae 216g Radix Paeoniae Alba 108g
Radix Stellariae 22g Radix Glycyrrhizae 27g
Semen Euryales (parched) 54g Rhizoma Chuanxiong 54g
Colla cornus cervi 108g Rhizoma Dioscoreae 108g
Ootheca Mantidis 40g Radix Angelicae Sinensis 122g
Radix Asparagi 54g Radix Rehmanniae Preparata 216g
(2) above 20 flavors, the Gallus Domesticus of getting removing feather claw and intestine is cut into piece, adds 2～5 times of water gagings, boiled 0.5～4 hour, and used 5-15 while hot: 1 hard paraffin defat adds 40-500 afterwards: 1 papain stirs, regulate pH value to 4～8,40 ℃～65 ℃, hydrolysis is after 2～8 hours, boil 2～20 minutes, centrifugal, supernatant is evaporated to thick paste, relative density surveys 1.02～1.32 for 60 ℃, at 50 ℃～100 ℃, and the 0.02-0.12Mpa vacuum drying, get dry extract, standby;
Get Carapax Trionycis (processed), decoct with water secondary, add 2～5 times in water at every turn, boiled 0.5～4 hour, filter, merging filtrate is evaporated to thick paste, 60 ℃ of surveys 1.02～1.32 of relative density, at 50 ℃～100 ℃, the 0.02-0.12Mpa vacuum drying gets dry extract, and is standby;
Get broken Radix Ginseng, the Radix Paeoniae Alba, Radix Asparagi, Radix Glycyrrhizae decocts with water secondary, add 2～8 times in water at every turn, decocted 0.5～3 hour, filter merging filtrate, filtrate or filtrate decompression is concentrated to relative density surveys 1.02～1.20 for 50 ℃, add the macroporous adsorptive resins of having handled well, every gram medical material restrains resin with 0.5-4, with 3～10 times of water gaging eluting, discards water lotion, reuse 50%～95% ethanol elution, do not have the saponin reaction to the eluent inspection, the eluent decompression recycling ethanol is to thick paste, and relative density surveys 1.02～1.34 for 60 ℃, at 50 ℃～100 ℃, 0.02-0.12Mpa vacuum drying gets dry extract, and is standby;
Get broken Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, the Radix Astragali, Ootheca Mantidis and Radix Stellariae, add 60%～80% ethanol, the reflux, extract, secondary, add 2～8 times of amounts of ethanol at every turn, refluxed 0.5～3 hour, and filtered merging filtrate, decompression recycling ethanol is to thick paste, relative density surveys 1.02～1.32 for 60 ℃, at 50 ℃～100 ℃, and the 0.02-0.12Mpa vacuum drying, get dry extract, standby;
Get broken Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Euryales (parched), Cornu Cervi Degelatinatum and Concha Ostreae (calcined) and decoct with water secondary, add 6～10 times in water at every turn, boiled 0.5～4 hour, filter, merging filtrate is evaporated to relative density and surveys 1.02～1.35 thick paste for 60 ℃, add 75～90% ethanol and stir, make that to contain the alcohol amount be 50～70%, standing over night, get supernatant, filter, decompression recycling ethanol is to thick paste, relative density surveys 1.02～1.32 for 60 ℃, at 50 ℃～100 ℃, and the 0.02-0.12Mpa vacuum drying, get dry extract, standby;
Get Rhizoma Cyperi (processed with vinegar) and add 4～8 times of water gagings, be heated to and boil, extract volatile oil till the oily defecation, volatile oil is standby;
Get Rhizoma Dioscoreae, Colla cornus cervi, pulverize separately becomes fine powder, crosses 100 mesh sieves, and is standby;
With each dry extract of above-mentioned gained, fine powder, adjuvant 2.1～18% mixed powders are broken into fine powder, cross 100 mesh sieves, granulate, and sieve; Spray into Rhizoma Cyperi volatile oil, mixing;
Above-mentioned gained is prepared in described ratio, make a kind of treatment QI and blood deficiency, menoxenia and bleeding not during menses medicine according to rules of preparations of Chinese Pharmacopoeia version in 2000.
2. a kind of preparation method for the treatment of QI and blood deficiency, menoxenia and bleeding not during menses medicine according to claim 1, the dosage form that it is characterized in that described medicine are tablet or soft capsule or capsule or granule or slow releasing tablet or drop pill or syrup or mixture.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN031300189A CN1215869C (en) | 2003-06-11 | 2003-06-11 | Black-bone chicken white phoenix preparation medicine and its preparing method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN031300189A CN1215869C (en) | 2003-06-11 | 2003-06-11 | Black-bone chicken white phoenix preparation medicine and its preparing method |
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| CN1457848A CN1457848A (en) | 2003-11-26 |
| CN1215869C true CN1215869C (en) | 2005-08-24 |
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Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1296083C (en) * | 2004-04-12 | 2007-01-24 | 北京乾露春科技有限公司 | Effervesce tablet of black-bone chicken and white phoenix, and preparation method |
| CN100339124C (en) * | 2005-01-21 | 2007-09-26 | 北京珠光会医药品研究开发有限公司 | Guiyuan oral liquid and its preparing process |
| CN1318066C (en) * | 2005-01-26 | 2007-05-30 | 河北省医学科学院 | Medicine for treating dysmenorrhes and preparation thereof |
| CN101406603B (en) * | 2007-10-10 | 2012-06-06 | 北京星昊医药股份有限公司 | Chinese herbal compound for treating gynaecologic metrorrhagia disease |
| CN102000250B (en) * | 2010-11-09 | 2013-09-25 | 郭伟光 | Black-bone chicken health-care medicament as well as preparation method and applications thereof |
| CN103127359B (en) * | 2013-02-26 | 2014-08-06 | 于纪魁 | TCM (traditional Chinese medicine) bone-strengthening capsule for treating senile osteoporosis |
| CN104740187B (en) * | 2013-12-27 | 2019-03-15 | 天津中新药业集团股份有限公司乐仁堂制药厂 | A kind of Wuji Baifeng composition and preparation method thereof |
| CN104740235B (en) * | 2013-12-27 | 2018-07-27 | 天津中新药业集团股份有限公司乐仁堂制药厂 | A kind of Chinese medicine composition and preparation method thereof |
| CN104740231B (en) * | 2013-12-27 | 2018-09-04 | 天津中新药业集团股份有限公司乐仁堂制药厂 | A kind of pharmaceutical composition and preparation method thereof treated under qi-blood deficiency, irregular menstruation and uterine bleeding band |
| CN104740175A (en) * | 2013-12-27 | 2015-07-01 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Silky fowl composition and preparation method thereof |
| CN104740230A (en) * | 2013-12-27 | 2015-07-01 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Silky fowl soft capsule and preparation method thereof |
| CN104740234B (en) * | 2013-12-27 | 2018-09-04 | 天津中新药业集团股份有限公司乐仁堂制药厂 | A kind of Chinese medicine composition and preparation method thereof |
| CN104740233B (en) * | 2013-12-27 | 2018-05-22 | 天津中新药业集团股份有限公司乐仁堂制药厂 | A kind of Chinese medicine composition and preparation method thereof |
| CN104740232B (en) * | 2013-12-27 | 2019-03-15 | 天津中新药业集团股份有限公司乐仁堂制药厂 | It is a kind of to treat qi-blood deficiency, irregular menstruation and the pharmaceutical composition of metrorrhagia and metrostaxis leukorrhagia and preparation method thereof |
| CN104740236B (en) * | 2013-12-27 | 2019-03-15 | 天津中新药业集团股份有限公司乐仁堂制药厂 | A kind of Wuji Baifeng dispersing tablet |
| CN104491357A (en) * | 2014-12-28 | 2015-04-08 | 李宏良 | Traditional Chinese medicine composition as well as preparation method and application thereof |
| CN104524415A (en) * | 2014-12-28 | 2015-04-22 | 李宏良 | Traditional Chinese medicine composition for treating diarrhea as well as preparation method and application thereof |
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2003
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