CN104491357A - Traditional Chinese medicine composition as well as preparation method and application thereof - Google Patents
Traditional Chinese medicine composition as well as preparation method and application thereof Download PDFInfo
- Publication number
- CN104491357A CN104491357A CN201410825498.5A CN201410825498A CN104491357A CN 104491357 A CN104491357 A CN 104491357A CN 201410825498 A CN201410825498 A CN 201410825498A CN 104491357 A CN104491357 A CN 104491357A
- Authority
- CN
- China
- Prior art keywords
- radix
- parts
- dry cream
- minutes
- adds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 64
- 238000002360 preparation method Methods 0.000 title claims abstract description 32
- 239000000203 mixture Substances 0.000 title claims description 49
- 208000024891 symptom Diseases 0.000 claims abstract description 18
- 239000008280 blood Substances 0.000 claims abstract description 16
- 210000004369 blood Anatomy 0.000 claims abstract description 16
- 230000007812 deficiency Effects 0.000 claims abstract description 14
- 210000003734 kidney Anatomy 0.000 claims abstract description 13
- 210000000952 spleen Anatomy 0.000 claims abstract description 7
- 208000008899 Habitual abortion Diseases 0.000 claims abstract description 6
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 claims abstract description 6
- 230000001684 chronic effect Effects 0.000 claims abstract description 6
- 239000000843 powder Substances 0.000 claims description 84
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 80
- 239000006071 cream Substances 0.000 claims description 72
- 241000209020 Cornus Species 0.000 claims description 44
- 238000001035 drying Methods 0.000 claims description 42
- 239000006187 pill Substances 0.000 claims description 41
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 41
- 235000012907 honey Nutrition 0.000 claims description 38
- 239000011812 mixed powder Substances 0.000 claims description 34
- 230000006837 decompression Effects 0.000 claims description 31
- 239000000706 filtrate Substances 0.000 claims description 24
- 239000012567 medical material Substances 0.000 claims description 24
- 238000004064 recycling Methods 0.000 claims description 24
- 238000003756 stirring Methods 0.000 claims description 24
- 238000001914 filtration Methods 0.000 claims description 23
- 241000208340 Araliaceae Species 0.000 claims description 22
- 241001550206 Colla Species 0.000 claims description 22
- 244000268590 Euryale ferox Species 0.000 claims description 22
- 235000006487 Euryale ferox Nutrition 0.000 claims description 22
- 241000287828 Gallus gallus Species 0.000 claims description 22
- 239000009636 Huang Qi Substances 0.000 claims description 22
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 22
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 22
- 235000008434 ginseng Nutrition 0.000 claims description 22
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 22
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 16
- 206010016825 Flushing Diseases 0.000 claims description 16
- 229910052799 carbon Inorganic materials 0.000 claims description 16
- 239000003480 eluent Substances 0.000 claims description 16
- 238000011010 flushing procedure Methods 0.000 claims description 16
- 238000000874 microwave-assisted extraction Methods 0.000 claims description 16
- 210000000582 semen Anatomy 0.000 claims description 14
- 229940079593 drug Drugs 0.000 claims description 13
- 206010003549 asthenia Diseases 0.000 claims description 12
- 239000002994 raw material Substances 0.000 claims description 12
- 239000012467 final product Substances 0.000 claims description 10
- 239000007787 solid Substances 0.000 claims description 9
- 235000021419 vinegar Nutrition 0.000 claims description 9
- 239000000052 vinegar Substances 0.000 claims description 9
- 208000019255 Menstrual disease Diseases 0.000 claims description 8
- 108090000526 Papain Proteins 0.000 claims description 8
- 239000004365 Protease Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 235000014593 oils and fats Nutrition 0.000 claims description 8
- 229940055729 papain Drugs 0.000 claims description 8
- 235000019834 papain Nutrition 0.000 claims description 8
- 239000012188 paraffin wax Substances 0.000 claims description 8
- 238000012545 processing Methods 0.000 claims description 8
- 239000006228 supernatant Substances 0.000 claims description 8
- 239000001993 wax Substances 0.000 claims description 8
- 210000000078 claw Anatomy 0.000 claims description 7
- 239000004744 fabric Substances 0.000 claims description 7
- 210000003746 feather Anatomy 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 7
- 210000000936 intestine Anatomy 0.000 claims description 7
- 238000011068 loading method Methods 0.000 claims description 7
- 238000004806 packaging method and process Methods 0.000 claims description 7
- 239000008188 pellet Substances 0.000 claims description 7
- 238000005453 pelletization Methods 0.000 claims description 7
- 239000008213 purified water Substances 0.000 claims description 7
- 238000007670 refining Methods 0.000 claims description 7
- 230000001954 sterilising effect Effects 0.000 claims description 7
- 238000004260 weight control Methods 0.000 claims description 7
- 206010046901 vaginal discharge Diseases 0.000 claims description 6
- 208000036119 Frailty Diseases 0.000 claims description 5
- 210000003756 cervix mucus Anatomy 0.000 claims description 5
- 238000000034 method Methods 0.000 abstract description 6
- 210000004185 liver Anatomy 0.000 abstract description 3
- 230000002969 morbid Effects 0.000 abstract 4
- 208000031971 Yin Deficiency Diseases 0.000 abstract 3
- 208000037093 Menstruation Disturbances Diseases 0.000 abstract 2
- 206010027339 Menstruation irregular Diseases 0.000 abstract 2
- 208000031975 Yang Deficiency Diseases 0.000 abstract 1
- 210000001161 mammalian embryo Anatomy 0.000 abstract 1
- 230000035764 nutrition Effects 0.000 abstract 1
- 235000016709 nutrition Nutrition 0.000 abstract 1
- 239000003053 toxin Substances 0.000 abstract 1
- 231100000765 toxin Toxicity 0.000 abstract 1
- 108700012359 toxins Proteins 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 9
- 238000005070 sampling Methods 0.000 description 6
- 239000009557 Bak Foong Pill Substances 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 239000002131 composite material Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000005242 forging Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 201000005630 leukorrhea Diseases 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000003014 reinforcing effect Effects 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/89—Cyperaceae (Sedge family)
- A61K36/8905—Cyperus (flatsedge)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8965—Asparagus, e.g. garden asparagus or asparagus fern
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2068—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/15—Preparation or pretreatment of starting material involving mechanical treatment, e.g. chopping up, cutting or grinding
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Zoology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Insects & Arthropods (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Immunology (AREA)
- Virology (AREA)
- Marine Sciences & Fisheries (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention provides a medicine for treating kidney-yang deficiency type morbid leucorrhea, kidney-yin deficiency type morbid leucorrhea, spleen deficiency type morbid leucorrhea, damp-heat type morbid leucorrhea, qi deficiency, yin deficiency, internal heat and liver heat type irregular menstruation symptoms, as well as a formula and a preparation method thereof, wherein the qi deficiency, the yin deficiency, the internal heat, the liver heat type irregular menstruation symptoms and the damp-heat toxins cause stasis of qi and blood and estrangement of branches of channels after a long time, and thus stasis symptom type chronic pelvic inflammation is caused; the deficiency of qi and blood or weakness of kidney qi or insecurity of thoroughfare and conception channels or nutrition loss of embryo cause habitual abortion. The preparation method of the medicine is safe in process, high in efficiency, quick acting, low in cost and convenient in preparation.
Description
Technical field
The present invention relates to the field of Chinese medicines, relate to medical composition and its use particularly.More specifically, the invention provides pharmaceutical composition, pharmaceutical composition is being prepared the purposes in medicine, prepared the method for medicine.
Background technology
WUJI BAIFENG WAN is used for benefiting qi and nourishing blood, adjusting meridian and stopping leukorrhea.For QI and blood deficiency, asthenic body, soreness of the waist and knees, menoxenia, leucorrhea amount is many, its prescription by Gallus Domesticus (removing feather claw and intestine), Colla cornus cervi, Carapax Trionycis (system), Concha Ostreae (forging), Ootheca Mantidis, Radix Ginseng, the Radix Astragali, Radix Angelicae Sinensis, the Radix Paeoniae Alba, Rhizoma Cyperi (vinegar system), Radix Asparagi, Radix Glycyrrhizae, Radix Rehmanniae, Radix Rehmanniae Preparata, Rhizoma Chuanxiong, Radix Stellariae, Radix Salviae Miltiorrhizae, Rhizoma Dioscoreae, Semen Euryales (stir-fry), Cornu Cervi Degelatinatum etc. 20 taste Chinese medicine forms, and it is the plus-minus side of size Gallus Domesticus ball in ancient book " Synopsis of Treating Women's Diseases ", estimates T&B.Wherein, the Radix Astragali, Radix Ginseng are used for QI invigorating; Colla cornus cervi, Cornu Cervi Degelatinatum are used for invigorating the liver and kidney; Ootheca Mantidis is used for receiving kidney-replenishing; Radix Angelicae Sinensis, Rhizoma Chuanxiong, the Radix Paeoniae Alba, the Radix Rehmanniae, be commonly called as SIWU TANG, for nourishing blood; Radix Salviae Miltiorrhizae, Concha Ostreae, other first are used for invigorating blood circulation, eliminating stagnation, YIN nourishing and calm the nerves; Radix Stellariae, Bie Jia have the use of clearind deficient heat; Radix Asparagi is YIN nourishing; Rhizoma Dioscoreae, Semen Euryales have spleen reinforcing, dry, reinforce the kidney and leukorrhagia stopping effect; Rhizoma Cyperi (processed) is then QI regulating medicine.Analyze from above, WUJI BAIFENG WAN be QI invigorating, nourish blood, regulating menstruation, leukorrhagia stopping, tonifying both YIN and YANG patent medicine, the scope of application is very wide, and exactly just because of this, WUJI BAIFENG WAN specific aim in disease therapy is not strong again.
Summary of the invention
The present invention is safe, efficient, quick-acting, cheap, easy to prepare in order to produce, and has treatment insufficiency of kidney-YANG leukorrhagia, deficiency of the kidney yin leukorrhagia, lukorrhagia due to hypofunction of the spleen, damp-heat vaginal discharge, the deficiency of vital energy, yin asthenia generating intrinsic heat, liver-heat menoxenia symptom; The deficiency of vital energy, yin asthenia generating intrinsic heat, liver-heat menoxenia symptom; Damp and hot silt poison, with the passing of time then QI and blood is retarded by silt, and channels is become estranged, and forms silt block symptom chronic pelvic inflammatory disease; Insufficiency of vital energy and blood or kidney qi are weak, the debility of CHONG and REN meridians, and tire is become homeless and supported and cause the medicine of habitual abortion.
The present invention is by following
A kind of Chinese medicine composition, its composition of raw materials is composed of the following components:
rhizoma Dioscoreae, Colla cornus cervi;
carapax Trionycis (processed with vinegar);
radix Ginseng, the Radix Paeoniae Alba, Radix Glycyrrhizae, the dry cream of Radix Asparagi;
the dry cream of Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Stellariae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Ootheca Mantidis, Rhizoma Cyperi (processed with vinegar);
concha Ostreae (calcined), Cornu Cervi Degelatinatum, Radix Rehmanniae, Radix Rehmanniae Preparata, the dry cream of Semen Euryales (parched);
the dry cream of removing feather claw and intestine Gallus Domesticus;
Described Rhizoma Dioscoreae, Colla cornus cervi are ground into 100 object fine powders;
Described Carapax Trionycis is broken into 200 object fine powders;
Described Gallus Domesticus is cut into below 5cm fritter, decocts with water 1 hour, adds the hard paraffin that people is appropriate while hot, stirring makes it dissolve, and leaves standstill, discards upper strata wax and oils and fats solid, decocting liquid stirs into homogenate, adds the papain that people is appropriate, stirs, be hydrolyzed 5 hours, boil 5 minutes, centrifugal, get supernatant, Jian Ya Nong Shrink becomes thick paste, then drying under reduced pressure is ground into the dry cream of 100-200 order;
Described Radix Ginseng, the Radix Paeoniae Alba, Radix Glycyrrhizae, the dry cream of Radix Asparagi are that mixed powder is broken into 100 object fine powders and adds medical material weight 6 times of soak by water 20 minutes, under 80 DEG C of conditions, 2450KHz microwave extraction 25 minutes, filter, merging filtrate, under being evaporated to 65 DEG C of conditions, relative density is about 1.05, pass through active carbon filtration, with 5 times amount 95% alcohol flushings, eluent decompression recycling ethanol Bing Nong Shrink is to paste, then drying under reduced pressure is ground into the dry cream of 50-100 object;
Described Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Stellariae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Rhizoma Cyperi, Ootheca Mantidis are that mixed powder is broken into 100 object fine powders and adds 75% ethanol of medical material weight 5 times under 75 DEG C of conditions, 2450KHz microwave extraction 25 minutes, filter, merging filtrate, decompression recycling ethanol is also concentrated, and drying under reduced pressure is ground into the dry cream of 50-100 order;
Described Concha Ostreae, Cornu Cervi Degelatinatum, Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Euryales are that mixed powder is broken into 100 object fine powders and adds medical material weight 6 times of soak by water secondaries, 2 hours first times, second time 1 hour, filter, merging filtrate, is evaporated to the clear paste that 65 DEG C of relative densities are 1.28 ~ 1. 33, pass through active carbon filtration, with 10 times amount 65% alcohol flushings, eluent decompression recycling ethanol Bing Nong Shrink is to paste, then drying under reduced pressure is ground into the dry cream of 50-100 order.
A kind of Chinese medicine composition, its composition of raw materials is composed of the following components:
rhizoma Dioscoreae, Colla cornus cervi;
carapax Trionycis (processed with vinegar);
radix Ginseng, the Radix Paeoniae Alba, Radix Glycyrrhizae, the dry cream of Radix Asparagi;
radix Salviae Miltiorrhizae, the Radix Astragali, Radix Stellariae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Ootheca Mantidis, the dry cream of Rhizoma Cyperi;
concha Ostreae, Cornu Cervi Degelatinatum, Radix Rehmanniae, Radix Rehmanniae Preparata, the dry cream of Semen Euryales;
the dry cream of removing feather claw and intestine Gallus Domesticus;
Described Rhizoma Dioscoreae, Colla cornus cervi are ground into 100 object fine powders;
Described Carapax Trionycis is broken into 200 object fine powders;
Described Gallus Domesticus is cut into below 5cm fritter, decocts with water 1 hour, adds the hard paraffin that people is appropriate while hot, stirring makes it dissolve, and leaves standstill, discards upper strata wax and oils and fats solid, decocting liquid stirs into homogenate, adds the papain that people is appropriate, stirs, be hydrolyzed 5 hours, boil 5 minutes, centrifugal, get supernatant, Jian Ya Nong Shrink becomes thick paste, then drying under reduced pressure is ground into the dry cream of 100-200 order;
Described Radix Ginseng, the Radix Paeoniae Alba, Radix Glycyrrhizae, the dry cream of Radix Asparagi are that mixed powder is broken into 100 object fine powders and adds medical material weight 6 times of soak by water 20 minutes, under 80 DEG C of conditions, 2450KHz microwave extraction 25 minutes, filter, merging filtrate, under being evaporated to 65 DEG C of conditions, relative density is about 1.05, pass through active carbon filtration, with 5 times amount 95% alcohol flushings, eluent decompression recycling ethanol Bing Nong Shrink is to paste, then drying under reduced pressure is ground into the dry cream of 50-100 object;
Described Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Stellariae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Rhizoma Cyperi, Ootheca Mantidis are that mixed powder is broken into 100 object fine powders and adds 75% ethanol of medical material weight 5 times under 75 DEG C of conditions, 2450KHz microwave extraction 25 minutes, filter, merging filtrate, decompression recycling ethanol is also concentrated, and drying under reduced pressure is ground into the dry cream of 50-100 order;
Described Concha Ostreae, Cornu Cervi Degelatinatum, Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Euryales are that mixed powder is broken into 100 object fine powders and adds medical material weight 6 times of soak by water secondaries, 2 hours first times, second time 1 hour, filter, merging filtrate, is evaporated to the clear paste that 65 DEG C of relative densities are 1.28 ~ 1. 33, pass through active carbon filtration, with 10 times amount 65% alcohol flushings, eluent decompression recycling ethanol Bing Nong Shrink is to paste, then drying under reduced pressure is ground into the dry cream of 50-100 order;
Described composition of raw materials weight ratio is: Gallus Domesticus 540 parts, Colla cornus cervi 108 parts, Carapax Trionycis 54g part, Concha Ostreae 40 parts, Ootheca Mantidis 40 parts, Radix Ginseng 108 parts, the Radix Astragali 27 parts, Radix Angelicae Sinensis 122 parts, the Radix Paeoniae Alba 108 parts, Rhizoma Cyperi 108 parts, Radix Asparagi 54 parts, 27 parts, Radix Glycyrrhizae, Radix Rehmanniae 216 parts, Radix Rehmanniae Preparata 216 parts, Rhizoma Chuanxiong 54 parts, Radix Stellariae 22 parts, Radix Salviae Miltiorrhizae 108 parts, Rhizoma Dioscoreae 108 parts, Semen Euryales 54 parts, Cornu Cervi Degelatinatum 40g part.
A kind of Chinese medicine composition, its composition of raw materials is composed of the following components:
rhizoma Dioscoreae, Colla cornus cervi;
carapax Trionycis (processed with vinegar);
radix Ginseng, the Radix Paeoniae Alba, Radix Glycyrrhizae, the dry cream of Radix Asparagi;
radix Salviae Miltiorrhizae, the Radix Astragali, Radix Stellariae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Ootheca Mantidis, the dry cream of Rhizoma Cyperi;
concha Ostreae, Cornu Cervi Degelatinatum, Radix Rehmanniae, Radix Rehmanniae Preparata, the dry cream of Semen Euryales;
the dry cream of removing feather claw and intestine Gallus Domesticus;
Described Rhizoma Dioscoreae, Colla cornus cervi are ground into 100 object fine powders;
Described Carapax Trionycis is broken into 200 object fine powders;
Described Gallus Domesticus is cut into below 5cm fritter, decocts with water 1 hour, adds the hard paraffin that people is appropriate while hot, stirring makes it dissolve, and leaves standstill, discards upper strata wax and oils and fats solid, decocting liquid stirs into homogenate, adds the papain that people is appropriate, stirs, be hydrolyzed 5 hours, boil 5 minutes, centrifugal, get supernatant, Jian Ya Nong Shrink becomes thick paste, then drying under reduced pressure is ground into the dry cream of 100-200 order;
Described Radix Ginseng, the Radix Paeoniae Alba, Radix Glycyrrhizae, the dry cream of Radix Asparagi are that mixed powder is broken into 100 object fine powders and adds medical material weight 6 times of soak by water 20 minutes, under 80 DEG C of conditions, 2450KHz microwave extraction 25 minutes, filter, merging filtrate, under being evaporated to 65 DEG C of conditions, relative density is about 1.05, pass through active carbon filtration, with 5 times amount 95% alcohol flushings, eluent decompression recycling ethanol Bing Nong Shrink is to paste, then drying under reduced pressure is ground into the dry cream of 50-100 object;
Described Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Stellariae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Rhizoma Cyperi, Ootheca Mantidis are that mixed powder is broken into 100 object fine powders and adds 75% ethanol of medical material weight 5 times under 75 DEG C of conditions, 2450KHz microwave extraction 25 minutes, filter, merging filtrate, decompression recycling ethanol is also concentrated, and drying under reduced pressure is ground into the dry cream of 50-100 order;
Described Concha Ostreae, Cornu Cervi Degelatinatum, Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Euryales are that mixed powder is broken into 100 object fine powders and adds medical material weight 6 times of soak by water secondaries, 2 hours first times, second time 1 hour, filter, merging filtrate, is evaporated to the clear paste that 65 DEG C of relative densities are 1.28 ~ 1. 33, pass through active carbon filtration, with 10 times amount 65% alcohol flushings, eluent decompression recycling ethanol Bing Nong Shrink is to paste, then drying under reduced pressure is ground into the dry cream of 50-100 order;
Described composition of raw materials weight ratio is: Gallus Domesticus 640 parts, Colla cornus cervi 128 parts, Carapax Trionycis 64g part, Concha Ostreae 48 parts, Ootheca Mantidis 48 parts, Radix Ginseng 128 parts, the Radix Astragali 32 parts, Radix Angelicae Sinensis 144 parts, the Radix Paeoniae Alba 128 parts, Rhizoma Cyperi 128 parts, Radix Asparagi 64 parts, 32 parts, Radix Glycyrrhizae, Radix Rehmanniae 256 parts, Radix Rehmanniae Preparata 256 parts, Rhizoma Chuanxiong 64 parts, Radix Stellariae 26 parts, Radix Salviae Miltiorrhizae 128 parts, Rhizoma Dioscoreae 128 parts, Semen Euryales 64 parts, Cornu Cervi Degelatinatum 48 parts.
Above-mentioned formula composition traditional Chinese medicine composite can be chosen respectively.
A preparation method for Chinese medicine composition, prepare according to following steps:
A mixes powder: formula gets above-mentioned fine medicinal material powder, dry cream in proportion, mixes thoroughly, 40-60 DEG C of cold drying, pulverize, mix all by 60-100 mesh sieve, sterilizing 45-60 minute, temperature 102-105 DEG C, dry, moisture is less than 4.5%, uses pelletizing machine granulate, pulverizes, fine powder is put in two-dimensional motion mixer and mix 40 minutes, sieve all by 60-100 order, by 100 mesh sieves, obtain mixed powder;
B refined honey: after getting former Mel dilute with water, filters, and in the spherical concentration tank of suction, decompression refining is 1.35-1.38 to relative density under 80 DEG C of conditions, and moisture Control, at 15-16.2%, with 100 order filter-cloth filterings, obtains refined honey;
C closes and sticks together: get crude drug powder, refined honey, every 100kg medicated powder refined honey 30-40kg, puts in trough type mixing machine, add appropriate purified water, mixes 45 minutes, makes the block that sticks together that soft or hard is suitable;
D pill: medicine is sticked together and inserts in pellet processing machine loading hopper, pill, wet ball Weight control is at 300-310mg ∕ 10 ball;
E encloses circle: according to wet ball hardness, carries out in right amount enclosing circle with mulse and medicated powder;
F is dry: evenly spread in drip pan by wet ball, and open baking oven, vacuum 0.6-0.8Kpa, temperature controls, at 30-60 DEG C of dry 2.5-3 hour, to obtain final product;
G learns from else's experience the pill be up to the standards, packaging.
A preparation method for Chinese medicine composition, prepare according to following steps:
A mixes powder: formula gets above-mentioned fine medicinal material powder, dry cream in proportion, mixes thoroughly, 50 DEG C of cold drying, pulverize, mix all by 100 mesh sieves, sterilizing 60 minutes, temperature 102-105 DEG C, dry, moisture is less than 4.5%, uses pelletizing machine granulate, pulverizes, fine powder is put in two-dimensional motion mixer and mix 40 minutes, sieve all by 100 orders, by 100 mesh sieves, obtain mixed powder;
B refined honey: after getting former Mel dilute with water, filters, and in the spherical concentration tank of suction, decompression refining is 1.35-1.38 to relative density under 80 DEG C of conditions, and moisture Control, at 15-16.2%, with 100 order filter-cloth filterings, obtains refined honey;
C closes and sticks together: get crude drug powder, refined honey, every 100kg medicated powder refined honey 30-40kg, puts in trough type mixing machine, add appropriate purified water, mixes 45 minutes, makes the block that sticks together that soft or hard is suitable;
D pill: medicine is sticked together and inserts in pellet processing machine loading hopper, pill, wet ball Weight control is at 300-310mg ∕ 10 ball;
E encloses circle: according to wet ball hardness, carries out in right amount enclosing circle with mulse and medicated powder;
F is dry: evenly spread in drip pan by wet ball, opens baking oven, vacuum 0.8Kpa, and temperature to control less than 50 DEG C drying 3 hours, to obtain final product;
G learns from else's experience the pill be up to the standards, packaging.
Choose above-mentioned traditional Chinese medicine composite, above-mentioned preparation technology can be adopted respectively to prepare corresponding medicine.
A purposes for Chinese medicine composition, is characterized in that: for the preparation of the medicine of the menoxenia for the treatment of insufficiency of kidney-YANG leukorrhagia, deficiency of the kidney yin leukorrhagia, lukorrhagia due to hypofunction of the spleen, damp-heat vaginal discharge, yin asthenia generating intrinsic heat, liver-heat symptom.
A purposes for Chinese medicine composition, is characterized in that: for the preparation of damp and hot malicious, that QI and blood is retarded by silt, the chronic pelvic inflammatory disease of silt block symptom is become estranged, formed to the channels medicine that becomes silted up for the treatment of.
A purposes for Chinese medicine composition, is characterized in that: for the preparation of the medicine of the habitual abortion for the treatment of insufficiency of vital energy and blood, kidney qi weakness, debility of CHONG and REN meridians symptom.
Medicine of the present invention, except being prepared into pill, can also adding one or more pharmaceutically acceptable carriers and be mixed and made into any one clinically or pharmaceutically acceptable dosage form, but preferred oral preparation pill.When being applied in the mode of oral administration the patient needing this treatment, conventional solid preparation can be made into, as pill, tablet, capsule, soft capsule etc.
Compared with prior art, according to the drug compound preparation obtained by medicinal material extract of the embodiment of the present invention, have employed kinds of traditional Chinese medicines mixing Novel extraction method, the extract active constituent content obtained is high, make preparation of the present invention be easy to prepare and the quality of the pharmaceutical preparations is significantly improved, design parameter is shown in embodiment.According to the pharmaceutical composition of the embodiment of the present invention have easy to implement, implementation result good, extract purity is high, easy, quality controllable feature prepared by preparation.
Advantage of the present invention is also embodied in the following aspects:
L, the present invention prepare simply, cheap, and curative effect is reliable, and treatment time is short, should not recur, and reduce toxic and side effects.
, the present invention by choose reasonable to medicine components, proportioning, achieve desirable therapeutic effect, both met state-promulgated pharmacopoeia to the requirement about drug dose, good therapeutic effect can have been ensured again, non-evident effect.
3, prescription of the present invention is the improvement on WUJI BAIFENG WAN formulation and technology, the main distinction improved adopts fine powder or fine powder to extract dry cream, and produce separately the stability retaining active component in each prescription in technique preparation, and binding tests designs best prescription ratio, best preparation production technology receives the above advantage.Multidigit Chinese medicine compound concentration extraction is obtained extractum by the present inventor originally, through experimentation repeatedly, the each component ratio of natural drug composition of the present invention and preparation extraction process produce synergism when combining, potentiation is obvious, extraordinary effect is played to side effect, especially at treatment insufficiency of kidney-YANG leukorrhagia, deficiency of the kidney yin leukorrhagia, lukorrhagia due to hypofunction of the spleen, damp-heat vaginal discharge, the deficiency of vital energy, yin asthenia generating intrinsic heat, liver-heat menoxenia symptom; The deficiency of vital energy, yin asthenia generating intrinsic heat, liver-heat menoxenia symptom; Damp and hot silt poison, with the passing of time then QI and blood is retarded by silt, and channels is become estranged, and forms silt block symptom chronic pelvic inflammatory disease; Insufficiency of vital energy and blood or kidney qi weakness, the debility of CHONG and REN meridians, tire is become homeless and is supported and cause habitual abortion Be very effective, this is that the present inventor pays a large amount of creative work and obtains, those of ordinary skill in the art simply cannot obtain this ratio range and optimum amount ratio only by disclosed content, and in this concrete preparation prescription and technique, do not reach the effect for the treatment of above disease.
, the present invention is theoretical for foundation with motherland traditional Chinese medical science marrow, development solely, special, effect formula.Adopt the pill prepared of this law to have good looking appearance, rounding is bright and clean, in the same size, rapid-action feature, and drug effect release evenly, without glutinous, the shortcoming such as tannin is many, pill is large prepared by former technique.
Detailed description of the invention
sampling mode 1,by following composition of raw materials weight ratio sampling, every part of 1g: Gallus Domesticus 540 parts, Colla cornus cervi 108 parts, Carapax Trionycis 54g part, Concha Ostreae 40 parts, Ootheca Mantidis 40 parts, Radix Ginseng 108 parts, the Radix Astragali 27 parts, Radix Angelicae Sinensis 122 parts, the Radix Paeoniae Alba 108 parts, Rhizoma Cyperi 108 parts, Radix Asparagi 54 parts, 27 parts, Radix Glycyrrhizae, Radix Rehmanniae 216 parts, Radix Rehmanniae Preparata 216 parts, Rhizoma Chuanxiong 54 parts, Radix Stellariae 22 parts, Radix Salviae Miltiorrhizae 108 parts, Rhizoma Dioscoreae 108 parts, Semen Euryales 54 parts, Cornu Cervi Degelatinatum 40g part.
Described Rhizoma Dioscoreae, Colla cornus cervi are ground into 100 object fine powders;
Described Carapax Trionycis is broken into 200 object fine powders;
Described Gallus Domesticus is cut into below 5cm fritter, decocts with water 1 hour, adds the hard paraffin that people is appropriate while hot, stirring makes it dissolve, and leaves standstill, discards upper strata wax and oils and fats solid, decocting liquid stirs into homogenate, adds the papain that people is appropriate, stirs, be hydrolyzed 5 hours, boil 5 minutes, centrifugal, get supernatant, Jian Ya Nong Shrink becomes thick paste, then drying under reduced pressure is ground into the dry cream of 100-200 order;
Described Radix Ginseng, the Radix Paeoniae Alba, Radix Glycyrrhizae, the dry cream of Radix Asparagi are that mixed powder is broken into 100 object fine powders and adds medical material weight 6 times of soak by water 20 minutes, under 80 DEG C of conditions, 2450KHz microwave extraction 25 minutes, filter, merging filtrate, under being evaporated to 65 DEG C of conditions, relative density is about 1.05, pass through active carbon filtration, with 5 times amount 95% alcohol flushings, eluent decompression recycling ethanol Bing Nong Shrink is to paste, then drying under reduced pressure is ground into the dry cream of 50-100 object;
Described Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Stellariae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Rhizoma Cyperi, Ootheca Mantidis are that mixed powder is broken into 100 object fine powders and adds 75% ethanol of medical material weight 5 times under 75 DEG C of conditions, 2450KHz microwave extraction 25 minutes, filter, merging filtrate, decompression recycling ethanol is also concentrated, and drying under reduced pressure is ground into the dry cream of 50-100 order;
Described Concha Ostreae, Cornu Cervi Degelatinatum, Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Euryales are that mixed powder is broken into 100 object fine powders and adds medical material weight 6 times of soak by water secondaries, 2 hours first times, second time 1 hour, filter, merging filtrate, is evaporated to the clear paste that 65 DEG C of relative densities are 1.28 ~ 1. 33, pass through active carbon filtration, with 10 times amount 65% alcohol flushings, eluent decompression recycling ethanol Bing Nong Shrink is to paste, then drying under reduced pressure is ground into the dry cream of 50-100 order.
sampling mode 2,by following composition of raw materials weight ratio sampling, every part of 1g: Gallus Domesticus 640 parts, Colla cornus cervi 128 parts, Carapax Trionycis 64g part, Concha Ostreae 48 parts, Ootheca Mantidis 48 parts, Radix Ginseng 128 parts, the Radix Astragali 32 parts, Radix Angelicae Sinensis 144 parts, the Radix Paeoniae Alba 128 parts, Rhizoma Cyperi 128 parts, Radix Asparagi 64 parts, 32 parts, Radix Glycyrrhizae, Radix Rehmanniae 256 parts, Radix Rehmanniae Preparata 256 parts, Rhizoma Chuanxiong 64 parts, Radix Stellariae 26 parts, Radix Salviae Miltiorrhizae 128 parts, Rhizoma Dioscoreae 128 parts, Semen Euryales 64 parts, Cornu Cervi Degelatinatum 48 parts.
Described Rhizoma Dioscoreae, Colla cornus cervi are ground into 100 object fine powders;
Described Carapax Trionycis is broken into 200 object fine powders;
Described Gallus Domesticus is cut into below 5cm fritter, decocts with water 1 hour, adds the hard paraffin that people is appropriate while hot, stirring makes it dissolve, and leaves standstill, discards upper strata wax and oils and fats solid, decocting liquid stirs into homogenate, adds the papain that people is appropriate, stirs, be hydrolyzed 5 hours, boil 5 minutes, centrifugal, get supernatant, Jian Ya Nong Shrink becomes thick paste, then drying under reduced pressure is ground into the dry cream of 100-200 order;
Described Radix Ginseng, the Radix Paeoniae Alba, Radix Glycyrrhizae, the dry cream of Radix Asparagi are that mixed powder is broken into 100 object fine powders and adds medical material weight 6 times of soak by water 20 minutes, under 80 DEG C of conditions, 2450KHz microwave extraction 25 minutes, filter, merging filtrate, under being evaporated to 65 DEG C of conditions, relative density is about 1.05, pass through active carbon filtration, with 5 times amount 95% alcohol flushings, eluent decompression recycling ethanol Bing Nong Shrink is to paste, then drying under reduced pressure is ground into the dry cream of 50-100 object;
Described Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Stellariae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Rhizoma Cyperi, Ootheca Mantidis are that mixed powder is broken into 100 object fine powders and adds 75% ethanol of medical material weight 5 times under 75 DEG C of conditions, 2450KHz microwave extraction 25 minutes, filter, merging filtrate, decompression recycling ethanol is also concentrated, and drying under reduced pressure is ground into the dry cream of 50-100 order;
Described Concha Ostreae, Cornu Cervi Degelatinatum, Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Euryales are that mixed powder is broken into 100 object fine powders and adds medical material weight 6 times of soak by water secondaries, 2 hours first times, second time 1 hour, filter, merging filtrate, is evaporated to the clear paste that 65 DEG C of relative densities are 1.28 ~ 1. 33, pass through active carbon filtration, with 10 times amount 65% alcohol flushings, eluent decompression recycling ethanol Bing Nong Shrink is to paste, then drying under reduced pressure is ground into the dry cream of 50-100 order.
Preparation method 1, A mixes powder: formula gets above-mentioned sampling mode 1 or 2 fine medicinal material powder, dry cream in proportion, mixes thoroughly, 40-60 DEG C of cold drying, pulverizes, mixes all by 60-100 mesh sieve, sterilizing 45-60 minute, temperature 102-105 DEG C, dry, moisture is less than 4.5%, use pelletizing machine granulate, pulverize, fine powder is put in two-dimensional motion mixer and mix 40 minutes, sieve all by 60-100 order, by 100 mesh sieves, obtain mixed powder;
B refined honey: after getting former Mel dilute with water, filters, and in the spherical concentration tank of suction, decompression refining is 1.35-1.38 to relative density under 80 DEG C of conditions, and moisture Control, at 15-16.2%, with 100 order filter-cloth filterings, obtains refined honey;
C closes and sticks together: get crude drug powder, refined honey, every 100kg medicated powder refined honey 30-40kg, puts in trough type mixing machine, add appropriate purified water, mixes 45 minutes, makes the block that sticks together that soft or hard is suitable;
D pill: medicine is sticked together and inserts in pellet processing machine loading hopper, pill, wet ball Weight control is at 300-310mg ∕ 10 ball;
E encloses circle: according to wet ball hardness, carries out in right amount enclosing circle with mulse and medicated powder;
F is dry: evenly spread in drip pan by wet ball, and open baking oven, vacuum 0.6-0.8Kpa, temperature controls, at 30-60 DEG C of dry 2.5-3 hour, to obtain final product;
G learns from else's experience the pill be up to the standards, packaging.
By every
50gmixed powder adds refined honey
20 ~ 25 gwith appropriate water pill, dry, make water-honeyed pill; Or add refined honey
60 ~ 80gmake small honey pill or big honeyed pills, to obtain final product.
Preparation method 2, A mixes powder: formula gets above-mentioned fine medicinal material powder, dry cream in proportion, mixes thoroughly, 50 DEG C of cold drying, pulverize, mix all by 100 mesh sieves, sterilizing 60 minutes, temperature 102-105 DEG C, dry, moisture is less than 4.5%, use pelletizing machine granulate, pulverize, fine powder is put in two-dimensional motion mixer and mix 40 minutes, sieve all by 100 orders, by 100 mesh sieves, obtain mixed powder;
B refined honey: after getting former Mel dilute with water, filters, and in the spherical concentration tank of suction, decompression refining is 1.35-1.38 to relative density under 80 DEG C of conditions, and moisture Control, at 15-16.2%, with 100 order filter-cloth filterings, obtains refined honey;
C closes and sticks together: get crude drug powder, refined honey, every 100kg medicated powder refined honey 30-40kg, puts in trough type mixing machine, add appropriate purified water, mixes 45 minutes, makes the block that sticks together that soft or hard is suitable;
D pill: medicine is sticked together and inserts in pellet processing machine loading hopper, pill, wet ball Weight control is at 300-310mg ∕ 10 ball;
E encloses circle: according to wet ball hardness, carries out in right amount enclosing circle with mulse and medicated powder;
F is dry: evenly spread in drip pan by wet ball, opens baking oven, vacuum 0.8Kpa, and temperature to control less than 50 DEG C drying 3 hours, to obtain final product;
G learns from else's experience the pill be up to the standards, packaging.
By every
50gmixed powder adds refined honey
20 ~ 25 gwith appropriate water pill, dry, make water-honeyed pill; Or add refined honey
60 ~ 80gmake small honey pill or big honeyed pills, to obtain final product.
Preparation method 3, A mixes powder: formula gets above-mentioned sampling mode 1 or 2 fine medicinal material powder, dry cream in proportion, mixes thoroughly, 40-60 DEG C of cold drying, pulverizes, mixes all by 60-100 mesh sieve, sterilizing 45-60 minute, temperature 102-105 DEG C, dry, moisture is less than 4.5%, use pelletizing machine granulate, pulverize, fine powder is put in two-dimensional motion mixer and mix 40 minutes, sieve all by 60-100 order, by 100 mesh sieves, obtain mixed powder;
B refined honey: after getting former Mel dilute with water, filters, and in the spherical concentration tank of suction, decompression refining is 1.35-1.38 to relative density under 80 DEG C of conditions, and moisture Control, at 15-16.2%, with 100 order filter-cloth filterings, obtains refined honey;
C closes and sticks together: get crude drug powder, refined honey, every 100kg medicated powder refined honey 30-40kg, puts in trough type mixing machine, add appropriate purified water, mixes 45 minutes, makes the block that sticks together that soft or hard is suitable;
D pill: medicine is sticked together and inserts in pellet processing machine loading hopper, pill, wet ball Weight control is at 300-310mg ∕ 10 ball;
E encloses circle: according to wet ball hardness, carries out in right amount enclosing circle with mulse and medicated powder;
F is dry: evenly spread in drip pan by wet ball, and open baking oven, vacuum 0.6-0.8Kpa, temperature controls, at 30-60 DEG C of dry 2.5-3 hour, to obtain final product;
G learns from else's experience the pill be up to the standards, packaging.
By every
50gmixed powder adds refined honey
20 ~ 25 gwith appropriate water pill, dry, make water-honeyed pill; Or add refined honey
60 ~ 80gmake small honey pill or big honeyed pills, to obtain final product.
With reference to WUJI BAIFENG WAN (sheet) existing drug standard, inspection product is qualified, and testing data is as follows:
All crude drugs, process by Chinese Pharmacopoeia regulation or Chinese medicine processing specification, all test method standards carry out with reference to Chinese Pharmacopoeia standard.
Oral.Water-honeyed pill once
3 g,small honey pill once
5 g,big honeyed pills once
1ball, one day
2secondary.
Within three weeks, be a course for the treatment of, general treatment needs three courses for the treatment of, and the person of being in a bad way adds can reach therapeutic purposes one to two courses for the treatment of.
This handicraft product effect is as follows:
Use medicine of the present invention, each 100 examples of menoxenia clinical case for the treatment of insufficiency of kidney-YANG leukorrhagia, deficiency of the kidney yin leukorrhagia, lukorrhagia due to hypofunction of the spleen, damp-heat vaginal discharge, yin asthenia generating intrinsic heat, liver-heat symptom, total effective rate is respectively 96%, 94%, 95%, 93%, 92%, 97%, basic cure rate 78%, 72%, 71%, 88%, 82%, 82%.
Use medicine of the present invention, treat damp and hot each 100 examples of malicious, that QI and blood is retarded by silt, silt block symptom is become estranged, formed to channels chronic pelvic inflammatory disease clinical case of becoming silted up, total effective rate is respectively 86%, 82%, 83%, 87%, basic cure rate 77%, 73%, 71%, 91%.
Use medicine of the present invention, each 100 examples for the treatment of insufficiency of vital energy and blood, kidney qi habitual abortion clinical case that is weak, debility of CHONG and REN meridians symptom, total effective rate is respectively 66%, 69%, 63%, 92%.
Claims (8)
1. a Chinese medicine composition, is characterized in that its composition of raw materials is composed of the following components:
rhizoma Dioscoreae, Colla cornus cervi;
carapax Trionycis (processed with vinegar);
radix Ginseng, the Radix Paeoniae Alba, Radix Glycyrrhizae, the dry cream of Radix Asparagi;
the dry cream of Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Stellariae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Ootheca Mantidis, Rhizoma Cyperi (processed with vinegar);
concha Ostreae (calcined), Cornu Cervi Degelatinatum, Radix Rehmanniae, Radix Rehmanniae Preparata, the dry cream of Semen Euryales (parched);
the dry cream of removing feather claw and intestine Gallus Domesticus;
Described Rhizoma Dioscoreae, Colla cornus cervi are ground into 100 object fine powders;
Described Carapax Trionycis is broken into 200 object fine powders;
Described Gallus Domesticus is cut into below 5cm fritter, decocts with water 1 hour, adds the hard paraffin that people is appropriate while hot, stirring makes it dissolve, and leaves standstill, discards upper strata wax and oils and fats solid, decocting liquid stirs into homogenate, adds the papain that people is appropriate, stirs, be hydrolyzed 5 hours, boil 5 minutes, centrifugal, get supernatant, Jian Ya Nong Shrink becomes thick paste, then drying under reduced pressure is ground into the dry cream of 100-200 order;
Described Radix Ginseng, the Radix Paeoniae Alba, Radix Glycyrrhizae, the dry cream of Radix Asparagi are that mixed powder is broken into 100 object fine powders and adds medical material weight 6 times of soak by water 20 minutes, under 80 DEG C of conditions, 2450KHz microwave extraction 25 minutes, filter, merging filtrate, under being evaporated to 65 DEG C of conditions, relative density is about 1.05, pass through active carbon filtration, with 5 times amount 95% alcohol flushings, eluent decompression recycling ethanol Bing Nong Shrink is to paste, then drying under reduced pressure is ground into the dry cream of 50-100 object;
Described Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Stellariae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Rhizoma Cyperi, Ootheca Mantidis are that mixed powder is broken into 100 object fine powders and adds 75% ethanol of medical material weight 5 times under 75 DEG C of conditions, 2450KHz microwave extraction 25 minutes, filter, merging filtrate, decompression recycling ethanol is also concentrated, and drying under reduced pressure is ground into the dry cream of 50-100 order;
Described Concha Ostreae, Cornu Cervi Degelatinatum, Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Euryales are that mixed powder is broken into 100 object fine powders and adds medical material weight 6 times of soak by water secondaries, 2 hours first times, second time 1 hour, filter, merging filtrate, is evaporated to the clear paste that 65 DEG C of relative densities are 1.28 ~ 1. 33, pass through active carbon filtration, with 10 times amount 65% alcohol flushings, eluent decompression recycling ethanol Bing Nong Shrink is to paste, then drying under reduced pressure is ground into the dry cream of 50-100 order.
2.
according to claim 1a kind of Chinese medicine composition, is characterized in that its composition of raw materials is composed of the following components:
rhizoma Dioscoreae, Colla cornus cervi;
carapax Trionycis (processed with vinegar);
radix Ginseng, the Radix Paeoniae Alba, Radix Glycyrrhizae, the dry cream of Radix Asparagi;
radix Salviae Miltiorrhizae, the Radix Astragali, Radix Stellariae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Ootheca Mantidis, the dry cream of Rhizoma Cyperi;
concha Ostreae, Cornu Cervi Degelatinatum, Radix Rehmanniae, Radix Rehmanniae Preparata, the dry cream of Semen Euryales;
the dry cream of removing feather claw and intestine Gallus Domesticus;
Described Rhizoma Dioscoreae, Colla cornus cervi are ground into 100 object fine powders;
Described Carapax Trionycis is broken into 200 object fine powders;
Described Gallus Domesticus is cut into below 5cm fritter, decocts with water 1 hour, adds the hard paraffin that people is appropriate while hot, stirring makes it dissolve, and leaves standstill, discards upper strata wax and oils and fats solid, decocting liquid stirs into homogenate, adds the papain that people is appropriate, stirs, be hydrolyzed 5 hours, boil 5 minutes, centrifugal, get supernatant, Jian Ya Nong Shrink becomes thick paste, then drying under reduced pressure is ground into the dry cream of 100-200 order;
Described Radix Ginseng, the Radix Paeoniae Alba, Radix Glycyrrhizae, the dry cream of Radix Asparagi are that mixed powder is broken into 100 object fine powders and adds medical material weight 6 times of soak by water 20 minutes, under 80 DEG C of conditions, 2450KHz microwave extraction 25 minutes, filter, merging filtrate, under being evaporated to 65 DEG C of conditions, relative density is about 1.05, pass through active carbon filtration, with 5 times amount 95% alcohol flushings, eluent decompression recycling ethanol Bing Nong Shrink is to paste, then drying under reduced pressure is ground into the dry cream of 50-100 object;
Described Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Stellariae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Rhizoma Cyperi, Ootheca Mantidis are that mixed powder is broken into 100 object fine powders and adds 75% ethanol of medical material weight 5 times under 75 DEG C of conditions, 2450KHz microwave extraction 25 minutes, filter, merging filtrate, decompression recycling ethanol is also concentrated, and drying under reduced pressure is ground into the dry cream of 50-100 order;
Described Concha Ostreae, Cornu Cervi Degelatinatum, Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Euryales are that mixed powder is broken into 100 object fine powders and adds medical material weight 6 times of soak by water secondaries, 2 hours first times, second time 1 hour, filter, merging filtrate, is evaporated to the clear paste that 65 DEG C of relative densities are 1.28 ~ 1. 33, pass through active carbon filtration, with 10 times amount 65% alcohol flushings, eluent decompression recycling ethanol Bing Nong Shrink is to paste, then drying under reduced pressure is ground into the dry cream of 50-100 order;
Described composition of raw materials weight ratio is: Gallus Domesticus 540 parts, Colla cornus cervi 108 parts, Carapax Trionycis 54g part, Concha Ostreae 40 parts, Ootheca Mantidis 40 parts, Radix Ginseng 108 parts, the Radix Astragali 27 parts, Radix Angelicae Sinensis 122 parts, the Radix Paeoniae Alba 108 parts, Rhizoma Cyperi 108 parts, Radix Asparagi 54 parts, 27 parts, Radix Glycyrrhizae, Radix Rehmanniae 216 parts, Radix Rehmanniae Preparata 216 parts, Rhizoma Chuanxiong 54 parts, Radix Stellariae 22 parts, Radix Salviae Miltiorrhizae 108 parts, Rhizoma Dioscoreae 108 parts, Semen Euryales 54 parts, Cornu Cervi Degelatinatum 40g part.
3.
according to claim 1a kind of Chinese medicine composition, is characterized in that its composition of raw materials is composed of the following components:
rhizoma Dioscoreae, Colla cornus cervi;
carapax Trionycis (processed with vinegar);
radix Ginseng, the Radix Paeoniae Alba, Radix Glycyrrhizae, the dry cream of Radix Asparagi;
radix Salviae Miltiorrhizae, the Radix Astragali, Radix Stellariae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Ootheca Mantidis, the dry cream of Rhizoma Cyperi;
concha Ostreae, Cornu Cervi Degelatinatum, Radix Rehmanniae, Radix Rehmanniae Preparata, the dry cream of Semen Euryales;
the dry cream of removing feather claw and intestine Gallus Domesticus;
Described Rhizoma Dioscoreae, Colla cornus cervi are ground into 100 object fine powders;
Described Carapax Trionycis is broken into 200 object fine powders;
Described Gallus Domesticus is cut into below 5cm fritter, decocts with water 1 hour, adds the hard paraffin that people is appropriate while hot, stirring makes it dissolve, and leaves standstill, discards upper strata wax and oils and fats solid, decocting liquid stirs into homogenate, adds the papain that people is appropriate, stirs, be hydrolyzed 5 hours, boil 5 minutes, centrifugal, get supernatant, Jian Ya Nong Shrink becomes thick paste, then drying under reduced pressure is ground into the dry cream of 100-200 order;
Described Radix Ginseng, the Radix Paeoniae Alba, Radix Glycyrrhizae, the dry cream of Radix Asparagi are that mixed powder is broken into 100 object fine powders and adds medical material weight 6 times of soak by water 20 minutes, under 80 DEG C of conditions, 2450KHz microwave extraction 25 minutes, filter, merging filtrate, under being evaporated to 65 DEG C of conditions, relative density is about 1.05, pass through active carbon filtration, with 5 times amount 95% alcohol flushings, eluent decompression recycling ethanol Bing Nong Shrink is to paste, then drying under reduced pressure is ground into the dry cream of 50-100 object;
Described Radix Salviae Miltiorrhizae, the Radix Astragali, Radix Stellariae, Rhizoma Chuanxiong, Radix Angelicae Sinensis, Rhizoma Cyperi, Ootheca Mantidis are that mixed powder is broken into 100 object fine powders and adds 75% ethanol of medical material weight 5 times under 75 DEG C of conditions, 2450KHz microwave extraction 25 minutes, filter, merging filtrate, decompression recycling ethanol is also concentrated, and drying under reduced pressure is ground into the dry cream of 50-100 order;
Described Concha Ostreae, Cornu Cervi Degelatinatum, Radix Rehmanniae, Radix Rehmanniae Preparata, Semen Euryales are that mixed powder is broken into 100 object fine powders and adds medical material weight 6 times of soak by water secondaries, 2 hours first times, second time 1 hour, filter, merging filtrate, is evaporated to the clear paste that 65 DEG C of relative densities are 1.28 ~ 1. 33, pass through active carbon filtration, with 10 times amount 65% alcohol flushings, eluent decompression recycling ethanol Bing Nong Shrink is to paste, then drying under reduced pressure is ground into the dry cream of 50-100 order;
Described composition of raw materials weight ratio is: Gallus Domesticus 640 parts, Colla cornus cervi 128 parts, Carapax Trionycis 64g part, Concha Ostreae 48 parts, Ootheca Mantidis 48 parts, Radix Ginseng 128 parts, the Radix Astragali 32 parts, Radix Angelicae Sinensis 144 parts, the Radix Paeoniae Alba 128 parts, Rhizoma Cyperi 128 parts, Radix Asparagi 64 parts, 32 parts, Radix Glycyrrhizae, Radix Rehmanniae 256 parts, Radix Rehmanniae Preparata 256 parts, Rhizoma Chuanxiong 64 parts, Radix Stellariae 26 parts, Radix Salviae Miltiorrhizae 128 parts, Rhizoma Dioscoreae 128 parts, Semen Euryales 64 parts, Cornu Cervi Degelatinatum 48 parts.
4. a preparation method for Chinese medicine composition, is characterized in that adopting following steps preparation by claim 1 or 2 or 3 formula:
A mixes powder: formula gets above-mentioned fine medicinal material powder, dry cream in proportion, mixes thoroughly, 40-60 DEG C of cold drying, pulverize, mix all by 60-100 mesh sieve, sterilizing 45-60 minute, temperature 102-105 DEG C, dry, moisture is less than 4.5%, uses pelletizing machine granulate, pulverizes, fine powder is put in two-dimensional motion mixer and mix 40 minutes, sieve all by 60-100 order, by 100 mesh sieves, obtain mixed powder;
B refined honey: after getting former Mel dilute with water, filters, and in the spherical concentration tank of suction, decompression refining is 1.35-1.38 to relative density under 80 DEG C of conditions, and moisture Control, at 15-16.2%, with 100 order filter-cloth filterings, obtains refined honey;
C closes and sticks together: get crude drug powder, refined honey, every 100kg medicated powder refined honey 30-40kg, puts in trough type mixing machine, add appropriate purified water, mixes 45 minutes, makes the block that sticks together that soft or hard is suitable;
D pill: medicine is sticked together and inserts in pellet processing machine loading hopper, pill, wet ball Weight control is at 300-310mg ∕ 10 ball;
E encloses circle: according to wet ball hardness, carries out in right amount enclosing circle with mulse and medicated powder;
F is dry: evenly spread in drip pan by wet ball, and open baking oven, vacuum 0.6-0.8Kpa, temperature controls, at 30-60 DEG C of dry 2.5-3 hour, to obtain final product;
G learns from else's experience the pill be up to the standards, packaging.
5. the preparation method of a kind of Chinese medicine composition according to claim 4, is characterized in that adopting following steps preparation by claim 1 or 2 or 3 formula:
A mixes powder: formula gets above-mentioned fine medicinal material powder, dry cream in proportion, mixes thoroughly, 50 DEG C of cold drying, pulverize, mix all by 100 mesh sieves, sterilizing 60 minutes, temperature 102-105 DEG C, dry, moisture is less than 4.5%, uses pelletizing machine granulate, pulverizes, fine powder is put in two-dimensional motion mixer and mix 40 minutes, sieve all by 100 orders, by 100 mesh sieves, obtain mixed powder;
B refined honey: after getting former Mel dilute with water, filters, and in the spherical concentration tank of suction, decompression refining is 1.35-1.38 to relative density under 80 DEG C of conditions, and moisture Control, at 15-16.2%, with 100 order filter-cloth filterings, obtains refined honey;
C closes and sticks together: get crude drug powder, refined honey, every 100kg medicated powder refined honey 30-40kg, puts in trough type mixing machine, add appropriate purified water, mixes 45 minutes, makes the block that sticks together that soft or hard is suitable;
D pill: medicine is sticked together and inserts in pellet processing machine loading hopper, pill, wet ball Weight control is at 300-310mg ∕ 10 ball;
E encloses circle: according to wet ball hardness, carries out in right amount enclosing circle with mulse and medicated powder;
F is dry: evenly spread in drip pan by wet ball, opens baking oven, vacuum 0.8Kpa, and temperature to control less than 50 DEG C drying 3 hours, to obtain final product;
G learns from else's experience the pill be up to the standards, packaging.
6. a purposes for Chinese medicine composition, is characterized in that: adopt the Chinese medicine composition of claim 4 or 5 preparation method for the preparation of the medicine of the menoxenia for the treatment of insufficiency of kidney-YANG leukorrhagia, deficiency of the kidney yin leukorrhagia, lukorrhagia due to hypofunction of the spleen, damp-heat vaginal discharge, yin asthenia generating intrinsic heat, liver-heat symptom by claim 1 or 2 or 3 formula.
7. a purposes for Chinese medicine composition, is characterized in that: adopt the Chinese medicine composition of claim 4 or 5 preparation method for the preparation of damp and hot malicious, that QI and blood is retarded by silt, the chronic pelvic inflammatory disease of silt block symptom is become estranged, formed to the channels medicine that becomes silted up for the treatment of by claim 1 or 2 or 3 formula.
8. a purposes for Chinese medicine composition, is characterized in that: adopt the Chinese medicine composition of claim 4 or 5 preparation method for the preparation of the medicine of the habitual abortion for the treatment of insufficiency of vital energy and blood, kidney qi weakness, debility of CHONG and REN meridians symptom by claim 1 or 2 or 3 formula.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410825498.5A CN104491357A (en) | 2014-12-28 | 2014-12-28 | Traditional Chinese medicine composition as well as preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410825498.5A CN104491357A (en) | 2014-12-28 | 2014-12-28 | Traditional Chinese medicine composition as well as preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN104491357A true CN104491357A (en) | 2015-04-08 |
Family
ID=52932871
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410825498.5A Pending CN104491357A (en) | 2014-12-28 | 2014-12-28 | Traditional Chinese medicine composition as well as preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104491357A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796944A (en) * | 2016-03-15 | 2016-07-27 | 张艳娟 | Pharmaceutical preparation for treating recurrent abortion |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1622997A (en) * | 1996-03-12 | 1997-09-18 | Teh-Shan Chang | Herb composition and an herbal plaster made from the same |
| CN1457848A (en) * | 2003-06-11 | 2003-11-26 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Black-bone chicken white phoenix preparation medicine and its preparing method |
| CN1537613A (en) * | 2003-10-22 | 2004-10-20 | 江西汇仁药业有限公司 | Novel concentrated pill of wuji-Baifeng contg. black-bone chicken |
| CN1562312A (en) * | 2004-04-12 | 2005-01-12 | 北京乾露春科技有限公司 | Effervesce tablet of black-bone chicken and white phoenix, and preparation method |
| CN101869644A (en) * | 2009-12-29 | 2010-10-27 | 江西赣药全新制药有限公司 | Dark-skinned chicken dispersible tablet and preparation process thereof |
| CN103961525A (en) * | 2014-05-07 | 2014-08-06 | 江西百神药业股份有限公司 | Method for preparing bak foong pills |
-
2014
- 2014-12-28 CN CN201410825498.5A patent/CN104491357A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1622997A (en) * | 1996-03-12 | 1997-09-18 | Teh-Shan Chang | Herb composition and an herbal plaster made from the same |
| CN1457848A (en) * | 2003-06-11 | 2003-11-26 | 天津中新药业集团股份有限公司乐仁堂制药厂 | Black-bone chicken white phoenix preparation medicine and its preparing method |
| CN1537613A (en) * | 2003-10-22 | 2004-10-20 | 江西汇仁药业有限公司 | Novel concentrated pill of wuji-Baifeng contg. black-bone chicken |
| CN1562312A (en) * | 2004-04-12 | 2005-01-12 | 北京乾露春科技有限公司 | Effervesce tablet of black-bone chicken and white phoenix, and preparation method |
| CN101869644A (en) * | 2009-12-29 | 2010-10-27 | 江西赣药全新制药有限公司 | Dark-skinned chicken dispersible tablet and preparation process thereof |
| CN103961525A (en) * | 2014-05-07 | 2014-08-06 | 江西百神药业股份有限公司 | Method for preparing bak foong pills |
Non-Patent Citations (2)
| Title |
|---|
| 彭六宝等: "《社区医生用药手册》", 31 May 2010, 湖南科学技术出版社 * |
| 本刊编辑部: "习惯性流产", 《中国社区医师》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105796944A (en) * | 2016-03-15 | 2016-07-27 | 张艳娟 | Pharmaceutical preparation for treating recurrent abortion |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107789484B (en) | Traditional Chinese medicine composition for treating irregular menstruation and preparation method thereof | |
| CN104922543A (en) | Medicine composite for treating amenorrhea and preparation method thereof | |
| CN103301440A (en) | Chinese medicine capable of warming Yang and tonifying kidneys | |
| CN103316192B (en) | Traditional Chinese medicine foot-bathing liquid for treating lumbocrural pain and preparation method thereof | |
| US10265369B2 (en) | Topical drug for treating breast cancer and preparation method thereof | |
| CN103223104B (en) | A kind of Chinese medicine composition treating diabetes and preparation method thereof | |
| CN104800720A (en) | Medicine for improving sexual desire of breeding bull and increasing yield of semen and preparation method of medicine | |
| CN102302609A (en) | Compound traditional Chinese drug preparation for improving subhealth | |
| CN103006879B (en) | Traditional Chinese medicine composition for treating climacteric syndrome and preparation method thereof | |
| CN101804175B (en) | Anti-cancer Chinese medicinal powder and preparation method thereof | |
| CN103341013B (en) | A kind of Chinese medicine for the treatment of lumbago and skelalgia | |
| CN103463406B (en) | Traditional Chinese medicine for treating sweating sickness of disharmony of heart and kidney | |
| CN102631437A (en) | Medicament for treating arthralgia and preparation method thereof | |
| CN104491357A (en) | Traditional Chinese medicine composition as well as preparation method and application thereof | |
| CN107334996B (en) | Anti-aging rejuvenation pill | |
| CN104587370A (en) | Traditional Chinese medicinal composition for treating liver cirrhosis | |
| CN101559124B (en) | Compound preparation for treating liver cancer and preparation method thereof | |
| CN104399036A (en) | Medicine composition for treating chronic diarrhea and application of medicine composition | |
| CN104056017A (en) | Traditional Chinese medicine composition for treating rheumatism and preparation method thereof | |
| CN110141656A (en) | A kind of Fuke Tiaojing blood-nourishing Chinese medicine composition and preparation method thereof | |
| CN114712470B (en) | Medicine for treating deficiency of kidney of men and preparation method thereof | |
| CN108452051A (en) | A kind of menstruation-regulating face-beautifying pharmaceutical capsules and preparation method | |
| CN104162090B (en) | Pharmaceutical composition and preparation method thereof | |
| CN103816388B (en) | A kind of treat Chinese medicine formula of bone marrow depression that Radiotherapy chemotherapy causes and preparation method thereof | |
| CN102366571A (en) | Medicine for treating imbalance of yin and yang caused by woman climacteric syndrome |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20150408 |