CN105796944A - Pharmaceutical preparation for treating recurrent abortion - Google Patents
Pharmaceutical preparation for treating recurrent abortion Download PDFInfo
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Abstract
The invention belongs to the technical field of traditional Chinese medicine and relates to a pharmaceutical preparation for treating yin-asthenia-generating-intrinsic-heat type recurrent abortion caused by blocking antibody deficiency and a preparation method thereof.The pharmaceutical preparation is meticulously prepared from 11 medicinal materials including radix rehmanniae praeparata, all-grass of intermediate peashrub, glossy privet fruits, Chinese holly leaves, radix paeoniae alba, herbal cistanche, all-grass of eleusinoides galingale, lalang grass rhizomes, common yam rhizomes, rhizoma cyperi and roots of stellaria yunnanensis.All the medicinal materials are under compatibility to achieve the effects of tonifying the kidney, soothing the liver, nourishing yin to clear heat, cooling blood to remove blood stasis, releasing liver depression, promoting qi circulation, promoting channel tropism of blood circulation, removing heat, calming blood, removing stasis and harmonizing collaterals; immunity is regulated, increase of blocking antibodies is promoted, yin-asthenia-generating-intrinsic-heat symptoms are relieved, and therefore the treatment effect is achieved.
Description
Technical field
The invention belongs to technical field of Chinese medicine, relate to a kind of blocking antibody for the treatment of and lack the pharmaceutical preparation causing recurrent abortion, especially a kind of yin asthenia generating intrinsic heat pattern of syndrome blocking antibody for the treatment of lacks pharmaceutical preparation causing recurrent abortion and preparation method thereof.
Background technology
Recurrent abortion (recurrentspontaneousabortion, RSA) is a kind of common pregnancy complications, refers to the fetus spontaneous abortion before occurring 2 times or more than 2 times pregnant 28 weeks with same spouse.The primary disease cause of disease and pathogenesis are considerably complicated, are also the difficult and complicated illness of global common concern.About the RSV of half is relevant with immunity, immune indexes thinks blocking antibody (blockingantibody, BA) Maximum Value, the research of blocking antibody and recurrent abortion becomes one of focus of primary disease research, blocking antibody is not enough or feminine gender can cause that paternal antigen is killed by mother's immune system identification, makes embryo be subject to immune attack and miscarry.
BA is lacked the RSA caused and adopts paternal or unrelated third party's individuality lymphocyte to carry out active immunity treatment by modern medicine; the quantity that can make the regulatory T cells in peripheral blood increases; induction parent produces immunologic tolerance; reduce the parent immune attack to embryo half alloantigen; suppress the cellular immunity rejection between female tire; protection embryo, reduces the purpose of abortion ratio.But it has Hematogenous infection, transfusion reaction, graft versus host disease, excites or increase the weight of the Potential danger factors such as autoimmune disease, and passive immunotherapy is blood products and expensive due to medicine, and patient is not easily accepted by.
Recurrent abortion is called " habitual abortion " by Chinese medicine, it is believed that the debility of CHONG and REN meridians of suffering from a deficiency of the kidney, and tire is become homeless and is, or deficiency-weakness of spleen-QI, carries and taking the photograph admittedly, and blood deficiency then moistens foster weary source, and deficiency is appointed in punching, and so that feotus vitality can not be conserved one's health habitual abortion occurs, other are also relevant to feelings will, blood stasis, heat in blood etc..Low for blocking antibody, the many angles from positive QI-insufficiency of the traditional Chinese medical science are analyzed, and healthy energy refers to the abilities such as body disease-resistant, eliminating evil, adjustment, reparation, is the coordination of body each several part, to global advantage and the effect of function system, this is the core concept of traditional Chinese medical science immunity."Fu Qingzhu works on obstetric" is said: " bosom of married woman is pregnant also generally, relies the kidney water stoppage of growth of the fetus, insufficient water sources, then fire easily boiling ... extreme misery two is sick, and tire can not be consolidated and falls." Jing-Yue Complete Works says: " and all fetal heat in pregnancy persons, blood movability, blood moves person, and tire is uneasy, therefore the void person in interior-heat that falls, also often there is it." the modern society young woman factor such as like losing weight, stay up late causes cloudy anemia to damage, the greatly and repeatedly habitual abortion of modern society's life in addition, operating pressure cause the factor such as anxiety, depression cause conscience hot and suffocating in disturb and the fact that yin asthenia generating intrinsic heat.
The history that Chinese medicine is prevented miscarriage existing several thousand, its curative effect is affirmative, has broad prospects.At present, bibliographical information is many to be controlled by weakness of the spleen and kidney or QI and blood deficiency opinion, and dialectical type is single, it is, therefore, desirable to provide the Chinese medicine composition of a kind of preventing and treating type of YIN-deficiency and interior-heat recurrent abortion with better curative effect.
Summary of the invention
Inventor is good at combining modern medical theory with traditional medical theory, dialectical combine with differential diagnosis of diseases, the etiology and pathogenesis of recurrent abortion is lacked for type of YIN-deficiency and interior-heat blocking antibody, based on clinical treatment experience for many years, learn wildly from other's strong points, hammer away, in order to overcome the deficiencies in the prior art, it is provided that a kind of blocking antibody for the treatment of lacks the pharmaceutical preparation causing recurrent abortion.
For achieving the above object, the present invention adopts the following technical scheme that
A kind of blocking antibody for the treatment of lacks the pharmaceutical preparation causing recurrent abortion, and it is by Radix Rehmanniae Preparata, Herba Caraganae intermediae, Fructus Ligustri Lucidi, Folium Ilicis Cornutae, the Radix Paeoniae Alba, Herba Cistanches, fringe dried tuber, Rhizoma Imperatae, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Stellariae Yunnanensis ten medicinal raw material elaborate simply.
In order to increase the coordinated effect between each raw material further, inventor is from improving curative effect of medication, the angle reducing side effect is set out, through Chinese medicine ingredients is screened, preferably go out following technical scheme: a kind of blocking antibody for the treatment of lacks the pharmaceutical preparation causing recurrent abortion, it is characterised by being made up of the medicinal raw material of following weight: Radix Rehmanniae Preparata 10-15 part, Herba Caraganae intermediae 12-17 part, Fructus Ligustri Lucidi 15-20 part, Folium Ilicis Cornutae 10-15 part, Radix Paeoniae Alba 7-12 part, Herba Cistanches 4-7 part, fringe dried tuber 8-13 part, Rhizoma Imperatae 7-12 part, Rhizoma Dioscoreae 20-26 part, Rhizoma Cyperi 7-12 part, Radix Stellariae Yunnanensis 15-20 part.
Further preferably, a kind of blocking antibody for the treatment of lacks the pharmaceutical preparation causing recurrent abortion, is characterised by being made up of the medicinal raw material of following weight: Radix Rehmanniae Preparata 12 parts, Herba Caraganae intermediae 15 parts, Fructus Ligustri Lucidi 18 parts, Folium Ilicis Cornutae 12 parts, the Radix Paeoniae Alba 8 parts, Herba Cistanches 5 parts, fringe dried tuber 10 parts, Rhizoma Imperatae 10 parts, Rhizoma Dioscoreae 25 parts, Rhizoma Cyperi 8 parts, Radix Stellariae Yunnanensis 15 parts.
Inventor thinks pathogenic fire derived from stagnation of liver-QI, and lower misfortune kidney yin, kidney yin is more empty, and stagnation of liver-QI is more puzzled；Yu Ze fire-transformation of a specified duration injures cloudy blood.Basis the mainly duty of immunity recurrent abortion in kidney, its mark then belongs to liver, with Radix Rehmanniae Preparata, Herba Caraganae intermediae, Fructus Ligustri Lucidi, Folium Ilicis Cornutae, the Radix Paeoniae Alba, Herba Cistanches, fringe dried tuber, Rhizoma Imperatae, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Stellariae Yunnanensis prescription, Fang Zhong: Radix Rehmanniae Preparata, Herba Caraganae intermediae nourishing YIN and supplementing blood, benefit essence fills out marrow, Huoxue Shugan；Two medicine 5 use, nourishing kidney-yin, kidney tonifying gas, live essence and blood, with solid protection its, for monarch drug.Fructus Ligustri Lucidi sweetness and bitterness is cool, replenishing YIN to strengthen the kidney, QI invigorating soothing liver-QI；Folium Ilicis Cornutae hardship is cool, clearing away heat and nourishing YIN, suppressing the hyperactive liver kidney tonifying；Radix Paeoniae Alba suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating；Three medicine compatibilities, clearing away heat and nourishing YIN, make stagnation of liver-QI return and reach, fate naturalization, blood is returned and is dispelled blood rather for ministerial drug through, heat.Herba Cistanches kidney-replenishing, nourishing kidney gas, the special YIN nourishing benefiting essence-blood of power, principal drug assistance treating YIN within YANG, with spermatogenesis blood；Fringe dried tuber promoting blood circulation and hemostasis, cool the blood dissipate blood stasis, Rhizoma Imperatae cooling blood for hemostasis, interior-heat can be removed, heat go then blood and, and then stagnation resolvation, help ministerial drug removing heat from blood and promoting blood circulation, heat extraction dissipating blood stasis；Rhizoma Dioscoreae spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission；Radix Stellariae Yunnanensis strengthening spleen and nourishing blood, the liver and the kidney tonifying；Rhizoma Cyperi promoting QI circulation for relieving depression, QI and blood regulating, have for adjuvant drug.All medicine 5 use, the kidney invigorating is soothing the liver, replenishing YIN and removing heat, cooling blood and removing stasis, makes stagnation of liver-QI return and reaches, fate naturalization, and blood is returned through heat blood of dispelling peaceful, the stasis of blood dissipate network and；Yi and Kui are derived from the same origin, Liver and kidney is ruled together, and regulates immunity, promoting that blocking antibody improves, improving all diseases of yin asthenia generating intrinsic heat, thus reaching therapeutic effect.
The pharmaceutical research present situation of each medical material used by the present invention is as described below.
Fructus Ligustri Lucidi: [nature and flavor] sweet, bitter, cold.[return through] returns liver, kidney channel.[function cures mainly] nourishing the liver and kidney, improving eyesight black hair.For vertigo and tinnitus, soreness of the waist and knees, early whitening of beard and hair, poor vision.
Folium Ilicis Cornutae: [nature and flavor] are bitter, cool.[return through] returns liver, kidney channel.[function cures mainly] clearing away heat and nourishing YIN, suppressing the hyperactive liver, kidney tonifying.Spit blood for pulmonary tuberculosis, osteopyrexia and fever, have a dizzy spell；Hypertension.[usage and dosage] 9～15g.
Radix Rehmanniae Preparata: [nature and flavor] are sweet, tepor.[return through] returns liver, kidney channel.[function cures mainly] nourishing YIN and supplementing blood, benefit essence fills out marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat is passed out semen, and interior-heat is quenched one's thirst, blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizziness, tinnitus, early whitening of beard and hair.[usage and dosage] 9～15g.
Herba Caraganae intermediae: [nature and flavor] are sweet；Temperature.[return through] liver；Kidney channel.[function cures mainly] nourishing YIN and supplementing blood, invigorates blood circulation.Main menoxenia.[usage and dosage] takes orally: decoct soup, 9-15g, fresh goods 20-30g.
Herba Cistanches: [nature and flavor] are sweet, salty, temperature.[return through] returns kidney, large intestine channel.[function cures mainly] kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation.For sexual impotence, infertile, soreness of the waist and knees, muscles and bones is unable, dryness of the intestine constipation.[usage and dosage] 6～9g.
Fringe dried tuber: for the herb of dried tuber plant fringe dried tuber.[nature and flavor] bitter in the mouth；Cool in nature.[return through] heart, liver two warp.[function cures mainly] promoting blood circulation and hemostasis.Main heat in blood is hemorrhage has the stagnant person of the stasis of blood concurrently.[usage and dosage] takes orally: decoct soup, 6-15g.
Rhizoma Dioscoreae: [nature and flavor] are sweet, flat.[return through] returns spleen, lung, kidney channel.[function cures mainly] spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) spleen reinforcing stomach invigorating.For insufficiency of the spleen lack of appetite, loose stool of having loose bowels, leukorrhagia.
Rhizoma Cyperi: [nature and flavor] hardship pungent, micro-, micro-sweet, flat.[return through] returns liver, spleen, tri-jiao channel.[function cures mainly] promoting QI circulation for relieving depression, menstruction regulating and pain relieving.For stagnation of QI due to depression of the liver, breast, the side of body, abdominal distention, dyspepsia, breast gastral cavity painful abdominal mass is vexed, and colic of cold type is suffered from abdominal pain, distending pain of the breast, menoxenia, amenorrhea dysmenorrhea.[usage and dosage] 6～9g.
The Radix Paeoniae Alba: [nature and flavor] are bitter, sour, are slightly cold.[return through] returns liver, spleen channel.[function cures mainly] suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.For dizziness of having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Rhizoma Imperatae: [nature and flavor] are sweet, cold.[return through] returns lung, stomach, bladder warp.[function cures mainly] cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria；Acute nephritis edema.
Radix Stellariae Yunnanensis: for the root of pinkwort Yunnan Herba stellariae mediae.[nature and flavor] are sweet；Property is put down.[return through] liver；Spleen；Kidney channel.[function cures mainly] strengthening spleen and nourishing blood；The liver and the kidney tonifying；Detumescence.Main anemia；Spirit is deficient；Dizzy nervous；Tinnitus dim eyesight；Hectic fever；Seminal emission；Menoxenia；Leukorrhagia；Fracture；Mastitis.[usage and dosage] takes orally: decoct soup, 15-30g；Or fricassee clothes.External: appropriate, fresh goods is smash deposited.
Treatment blocking antibody provided by the present invention lacks the pharmaceutical preparation causing recurrent abortion, directly Radix Rehmanniae Preparata, Herba Caraganae intermediae, Fructus Ligustri Lucidi, Folium Ilicis Cornutae, the Radix Paeoniae Alba, Herba Cistanches, fringe dried tuber, Rhizoma Imperatae, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Stellariae Yunnanensis can be pulverized, prepare into pulvis and be administered orally；Each component directly can also be mixed and made into coarse powder, the effective ingredient extracted in coarse powder makes extractum, extractum is utilized to prepare into peroral dosage form, such as tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, granule, honey pill agent, powder, sublimed preparation, solution etc., it is also possible to prepare into and be suitable to treatment blocking antibody and lack and cause other dosage form of recurrent abortion.
Inventor considers the factors such as recipe quantity, pharmaceutical properties, medication object, easy to use, cost of manufacture, it is preferable that make capsule, tablet, granule；Most preferably making capsule, be directly mixed and made into coarse powder by each component, extract the effective ingredient system in coarse powder, this effective ingredient individually or mixes with pharmaceutically acceptable carrier, is prepared from according to galenic pharmacy routine techniques.
The preparation method that present invention also offers a kind of pharmaceutical preparation described above.The preparation method of this pharmaceutical preparation provided by the invention, it comprises the steps:
(1) Herba Caraganae intermediae, the Radix Paeoniae Alba, fringe dried tuber, Rhizoma Cyperi are pulverized, with 65-70% alcohol reflux 1-3 time, united extraction liquid, concentrating under reduced pressure obtains rare extractum, upper polyamide column, first with pure water be eluted to effluent colourless after use 90% ethanol elution again, collecting ethanol elution, decompression recycling ethanol is to without alcohol taste, continuing to be concentrated into extractum, lyophilization, obtains the dry cream of Chinese medicine；
(2) by Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, Folium Ilicis Cornutae, Herba Cistanches, Rhizoma Imperatae, Rhizoma Dioscoreae, Radix Stellariae Yunnanensis boiling secondary, add water into medical material weight portion 4-10 times for the first time, decoct 1.0-1.5 hour, add water as medical material weight portion 3-8 times of second time decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.03-1.08 (60 DEG C record), adding ethanol makes alcohol content reach 35%, stands 12 hours in 0-5 DEG C, filters, filtrate recycling ethanol, it is concentrated into extractum, lyophilization, obtains the dry cream of Chinese medicine；
Mixing homogeneously after broken with the Chinese medicine dried cream powder of (2) gained to (1), this composition individually or mixes with pharmaceutically acceptable carrier, makes the pharmaceutical preparation of the present invention according to galenic pharmacy routine techniques.
Pharmaceutically acceptable carrier described above is optional freely: starch, Icing Sugar, dextrin, microcrystalline cellulose, amylum pregelatinisatum, magnesium stearate, micropowder silica gel, fructose, carboxymethyl starch sodium, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose, vegetable oil, lecithin, Polyethylene Glycol, propylene glycol, ethyl hydroxybenzoate etc..
The present invention is that inventor is through repeatedly studying, progressively improve, last successfully a kind of good pharmaceutical preparation of curative effect, and demonstrate the curative effect of pharmaceutical preparation of the present invention further by clinical case, details are as follows: blocking antibody is lacked the observation of curative effect test causing recurrent abortion by pharmaceutical preparation of the present invention:
1 data and method
1.1 physical data: include institute of traditional Chinese medicine of Shandong Province in December, 2013 in December ,-2014 diagnosis and treatment 106 example patient altogether in as object of study, employing is random is divided into treatment group and matched group by digits table with 1:1, wherein treatment group 53 example, 24～37 years old age, year mean age (28.8 ± 3.8)；Abortion times 2～6 times, average (2.6 ± 1.3) are secondary；Matched group 53 example, 23～38 years old age, year mean age (28.2 ± 3.3)；Abortion times 2～6 times, average (2.7 ± 1.8) are secondary, and two groups of patient ages, abortion times compare, no significant difference (P > 0.05), have comparability.
1.2 diagnostic criterias:
1.2.1 the diagnostic criteria of recurrent abortion: with reference to " Gynecology of Chinese Medicine " (Zhang Yuzhen) relevant criterion: suffer fetal loss person before the gestation 28 weeks of 2 times or more than 2 times with homogeneity companion continuously；Blocking antibody is negative.
1.2.2 TCM Syndrome Type standard: draft " yin asthenia generating intrinsic heat " pattern of syndrome standard with reference to " new Chinese medicine guideline of clinical investigations ", " Gynecology of Chinese Medicine " (Zhang Yuzhen) and " disease of tcm Standardization of diagnosis and curative effect ", advanced menstrual period, the few color of amount is red, hectically flushed cheeks, dry mouth and throat, feverish sensation in the palms and soles, agitation is not peaceful, or emaciated physique；Red tongue, few tongue, thready and rapid pulse.
1.3 include in, exclusion standard:
1.3.1 inclusive criteria: meeting above-mentioned diagnostic criteria, the women of child-bearing age at 22～40 years old age, signature Informed Consent Form also can adhere to therapist according to plan.
1.3.2 exclusion standard: couple or side's karyotype have exception；The positives such as antisperm antibody, anticardiolipin antibody or anti-endometrial antibodies；The anatomic abnormalities of reproductive tract infection or reproductive tract；Merge genital system tumor (optimum or pernicious)；Merge whole body serious systemic disease, tumor or psychotic.
1.4 Therapeutic Method
Treatment group: the capsule of the oral embodiment of the present invention 1 preparation, every day 2 times, each 2-4 grain, takes after meal half an hour, and treatment 3 months is 1 course for the treatment of continuously.
Matched group: adopt spouse's lymphocyte active immunity treatment method: at interval of immunity in 3 weeks 1 time, be for 4 times 1 course for the treatment of.
The blocking antibody of two groups of patients is checked after terminating 1 course for the treatment of, if blocking antibody transfers the positive to, advise patient to become pregnant, need after treatment group gestation to continue oral Chinese medicine decoction, and should exceed the maximum gestation month of previously miscarriage, during matched group gestation 5 weeks, again inject lymphocyte 1 time.
1.5 observation index: check patient's blocking antibody, observe two groups of patient's blocking antibody Conversion rate；(gestation exceedes and previously miscarries month, and B ultrasonic prompting embryo or fetal development are normal, for Pregnancy Success to observe two groups of patient's Pregnancy Success rates；If again miscarrying, for Pregnancy failure).Patient is every 1 progesterone of weekly check, E2 and HCG value after becoming pregnant；When, after menolipsis 42～63d, checking color ultrasound；Two groups of tcm symptoms scoring improvement situation (by degree without, light, in, heavily classification, its corresponding score value respectively 0,1,2,3 points).Adopt nimodipine method, i.e. integration × 100% before (before treatment integration after integration-treatment)/treatment.
1.6 statistical methods: adopt SPSS15.0 statistical software to be calculated.Each numerical value withRepresenting, measurement data adopts t inspection, and enumeration data adopts χ2Inspection, statistically significant for difference with P < 0.05.
2 results
The comparison of 2.1 liang of group treatment rear enclosed Positive seroconversion rate: after two groups of blocking antibody Conversion rate the 1st course of therapy terminate, treatment group, matched group patient's blocking antibody sun respectively turns 47,43 examples, blocking antibody Conversion rate respectively 88.7%, 81.1%, treatment group blocking antibody Conversion rate is slightly above matched group, no significant difference (P > 0.05).In Table 1.
The comparison of 1 liang of table group treatment rear enclosed Positive seroconversion rate
The comparison of Pregnancy Success rate after 2.2 liang of group treatments: after terminating the 1st course for the treatment of, two groups of patient's Pregnancy Success rates compare, treatment group, matched group be successful pregnancy 45 example, 34 examples respectively, successful pregnancy rate respectively 95.7%, 79.1%, treatment group Pregnancy Success rate is apparently higher than matched group, and difference has statistical significance (P < 0.05).In Table 2.(Pregnancy Success rate=Pregnancy Success number of cases/often organize gestation number of cases × 100%)
The comparison of Pregnancy Success rate after the group treatment of 2 liang of table
Note: compare with matched group, * P < 0.05.
Before and after 2.3 liang of group treatments, TCM symptom score compares: after the treatment for the treatment of group, TCM symptom score is all substantially more less than before treatment, with comparing difference statistically significant (P < 0.01) before treatment, matched group compares with before treatment, no significant difference (P > 0.05)；Comparing between two groups after treatment, treatment group is better than matched group in improving tcm symptom, and the minimizing for the treatment of group symptom integral becomes apparent from, difference statistically significant (P < 0.01).In Table 3.
3 liang of table group treatment before and after TCM symptom score compare (Point)
Note: compare with before treatment, * P < 0.01, compare the same period with matched group,#P < 0.01.
2.4 safety conditions: after treating 3 months, routine blood test, routine urinalysis, electrocardiogram change without exception before and after treatment group patient treatment, in therapeutic process, vital sign is steadily and without the untoward reaction such as nausea and vomiting, allergy, illustrates that our clinical application is safe and reliable.
The study show that Drug therapy of the present invention can advantageously promote the generation of blocking antibody, thus stoping Maternal-fetal immunity system to fetal challenge, being beneficial to pregnancy maintenance, improving Pregnancy Success rate, it should be a kind of better therapeutic scheme that blocking antibody shortage causes RSA patient.Therefore, the present invention is also claimed said medicine preparation and lacks, at preparation treatment blocking antibody, the purposes caused in the medicine of recurrent abortion, especially prepares treatment blocking antibody and lacks and cause recurrent abortion Chinese medical discrimination and belong to the purposes in the medicine of syndrome of endogenous heat due to yin deficiency.
In a word: compared with prior art, the present invention both have followed Chinese medical discrimination medicine law, has incorporated again modern pharmacology, legislation is comprehensively, prescription is rigorous rationally, and full side closes 5, has the kidney invigorating soothing the liver, replenishing YIN and removing heat, the merit of cooling blood and removing stasis, has Mutiple Targets, too many levels, multi-level comprehensive regulation effect, regulates immunity, promote that blocking antibody improves, improve the effect of all diseases of yin asthenia generating intrinsic heat.
The component of the present composition all adopts natural raw material of Chinese medicine, and preparation is easy, medicine source is wide, cost is low for it.It follows the prescriptions principle of the traditional Chinese medical science, reliable effect, mild in medicine property and, toxic and side effects does not occur,
The present invention can not only change the symptom of habitual abortion patient, and can improve the blocking antibody level of habitual abortion patient, promotes that blocking antibody turns sun；On the other hand, treatment by Chinese herbs habitual abortion, the potential risks such as the transfer overcome the propagation passing the infectious disease that active immunity treatment primary disease exists, promoting tumor and anti-graft disease, part infectious disease is carried patient and can also implement treatment, eliminate the fear that Hematogenic infectious disease is propagated by patient.
Detailed description of the invention
Further describing the present invention below by way of specific embodiment, the present invention is not limited only to following example.Within the scope of the invention or without departing from present disclosure, spirit and scope, change, combination or the replacement that the present invention is carried out, will be apparent to the person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 capsule
Prescription: Radix Rehmanniae Preparata 12 parts, Herba Caraganae intermediae 15 parts, Fructus Ligustri Lucidi 18 parts, Folium Ilicis Cornutae 12 parts, the Radix Paeoniae Alba 8 parts, Herba Cistanches 5 parts, fringe dried tuber 10 parts, Rhizoma Imperatae 10 parts, Rhizoma Dioscoreae 25 parts, Rhizoma Cyperi 8 parts, Radix Stellariae Yunnanensis 15 parts.
Preparation method: Herba Caraganae intermediae, the Radix Paeoniae Alba, fringe dried tuber, Rhizoma Cyperi are pulverized by (1), with 65-70% alcohol reflux 1-3 time, united extraction liquid, concentrating under reduced pressure obtains rare extractum, upper polyamide column, first with pure water be eluted to effluent colourless after use 90% ethanol elution again, collecting ethanol elution, decompression recycling ethanol is to without alcohol taste, continuing to be concentrated into extractum, lyophilization, obtains the dry cream of Chinese medicine；
(2) by Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, Folium Ilicis Cornutae, Herba Cistanches, Rhizoma Imperatae, Rhizoma Dioscoreae, Radix Stellariae Yunnanensis boiling secondary, add water into medical material weight portion 4-10 times for the first time, decoct 1.0-1.5 hour, add water as medical material weight portion 3-8 times of second time decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.03-1.08 (60 DEG C record), adding ethanol makes alcohol content reach 35%, stands 12 hours in 0-5 DEG C, filters, filtrate recycling ethanol, it is concentrated into extractum, lyophilization, obtains the dry cream of Chinese medicine；
Mix homogeneously after broken with the Chinese medicine dried cream powder of (2) gained to (1), make the pharmaceutical preparation of the present invention according to galenic pharmacy routine techniques.The present embodiment capsule every contains crude drug 0.7g.
Embodiment 2 capsule
Prescription: Radix Rehmanniae Preparata 10 parts, Herba Caraganae intermediae 12 parts, Fructus Ligustri Lucidi 15 parts, Folium Ilicis Cornutae 12 parts, the Radix Paeoniae Alba 10 parts, Herba Cistanches 5 parts, fringe dried tuber 12 parts, Rhizoma Imperatae 7 parts, Rhizoma Dioscoreae 20 parts, Rhizoma Cyperi 8 parts, Radix Stellariae Yunnanensis 18 parts.
Preparation method: the operation with reference to embodiment 1 carries out.
Embodiment 3 capsule
Prescription: Radix Rehmanniae Preparata 12 parts, Herba Caraganae intermediae 15 parts, Fructus Ligustri Lucidi 15 parts, Folium Ilicis Cornutae 15 parts, the Radix Paeoniae Alba 10 parts, Herba Cistanches 7 parts, fringe dried tuber 8 parts, Rhizoma Imperatae 12 parts, Rhizoma Dioscoreae 22 parts, Rhizoma Cyperi 10 parts, Radix Stellariae Yunnanensis 15 parts.
Preparation method: the operation with reference to embodiment 1 carries out.
Embodiment 4 capsule
Prescription: Radix Rehmanniae Preparata 15 parts, Herba Caraganae intermediae 17 parts, Fructus Ligustri Lucidi 20 parts, Folium Ilicis Cornutae 10 parts, the Radix Paeoniae Alba 10 parts, Herba Cistanches 6 parts, fringe dried tuber 12 parts, Rhizoma Imperatae 12 parts, Rhizoma Dioscoreae 20 parts, Rhizoma Cyperi 8 parts, Radix Stellariae Yunnanensis 15 parts.
Preparation method: the operation with reference to embodiment 1 carries out.
Embodiment 5 capsule
Prescription: Radix Rehmanniae Preparata 12 parts, Herba Caraganae intermediae 12 parts, Fructus Ligustri Lucidi 15 parts, Folium Ilicis Cornutae 15 parts, the Radix Paeoniae Alba 7 parts, Herba Cistanches 4 parts, fringe dried tuber 8 parts, Rhizoma Imperatae 10 parts, Rhizoma Dioscoreae 26 parts, Rhizoma Cyperi 8 parts, Radix Stellariae Yunnanensis 20 parts.
Preparation method: the operation with reference to embodiment 1 carries out.
Embodiment 6 capsule
Prescription: Radix Rehmanniae Preparata 15 parts, Herba Caraganae intermediae 15 parts, Fructus Ligustri Lucidi 15 parts, Folium Ilicis Cornutae 15 parts, the Radix Paeoniae Alba 10 parts, Herba Cistanches 5 parts, fringe dried tuber 12 parts, Rhizoma Imperatae 8 parts, Rhizoma Dioscoreae 20 parts, Rhizoma Cyperi 12 parts, Radix Stellariae Yunnanensis 15 parts.
Preparation method: the operation with reference to embodiment 1 carries out.
Embodiment 7 tablet
Prescription: Radix Rehmanniae Preparata 12 parts, Herba Caraganae intermediae 15 parts, Fructus Ligustri Lucidi 18 parts, Folium Ilicis Cornutae 12 parts, the Radix Paeoniae Alba 8 parts, Herba Cistanches 5 parts, fringe dried tuber 10 parts, Rhizoma Imperatae 12 parts, Rhizoma Dioscoreae 20 parts, Rhizoma Cyperi 12 parts, Radix Stellariae Yunnanensis 15 parts.
Preparation method: Herba Caraganae intermediae, the Radix Paeoniae Alba, fringe dried tuber, Rhizoma Cyperi are pulverized by (1), with 65-70% alcohol reflux 1-3 time, united extraction liquid, concentrating under reduced pressure obtains rare extractum, upper polyamide column, first with pure water be eluted to effluent colourless after use 90% ethanol elution again, collecting ethanol elution, decompression recycling ethanol is to without alcohol taste, continuing to be concentrated into extractum, lyophilization, obtains the dry cream of Chinese medicine；
(2) by Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, Folium Ilicis Cornutae, Herba Cistanches, Rhizoma Imperatae, Rhizoma Dioscoreae, Radix Stellariae Yunnanensis boiling secondary, add water into medical material weight portion 4-10 times for the first time, decoct 1.0-1.5 hour, add water as medical material weight portion 3-8 times of second time decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.03-1.08 (60 DEG C record), adding ethanol makes alcohol content reach 35%, stands 12 hours in 0-5 DEG C, filters, filtrate recycling ethanol, it is concentrated into extractum, lyophilization, obtains the dry cream of Chinese medicine；
Mix homogeneously after broken with the Chinese medicine dried cream powder of (2) gained to (1), make the pharmaceutical preparation of the present invention according to galenic pharmacy routine techniques.The present embodiment capsule every contains crude drug 0.65g.
Embodiment 8 granule
Prescription: Radix Rehmanniae Preparata 12 parts, Herba Caraganae intermediae 15 parts, Fructus Ligustri Lucidi 18 parts, Folium Ilicis Cornutae 12 parts, the Radix Paeoniae Alba 8 parts, Herba Cistanches 5 parts, fringe dried tuber 10 parts, Rhizoma Imperatae 10 parts, Rhizoma Dioscoreae 25 parts, Rhizoma Cyperi 8 parts, Radix Stellariae Yunnanensis 15 parts.
Preparation method: Herba Caraganae intermediae, the Radix Paeoniae Alba, fringe dried tuber, Rhizoma Cyperi are pulverized by (1), with 65-70% alcohol reflux 1-3 time, united extraction liquid, concentrating under reduced pressure obtains rare extractum, upper polyamide column, first with pure water be eluted to effluent colourless after use 90% ethanol elution again, collecting ethanol elution, decompression recycling ethanol is to without alcohol taste, continuing to be concentrated into extractum, lyophilization, obtains the dry cream of Chinese medicine；
(2) by Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, Folium Ilicis Cornutae, Herba Cistanches, Rhizoma Imperatae, Rhizoma Dioscoreae, Radix Stellariae Yunnanensis boiling secondary, add water into medical material weight portion 4-10 times for the first time, decoct 1.0-1.5 hour, add water as medical material weight portion 3-8 times of second time decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.03-1.08 (60 DEG C record), adding ethanol makes alcohol content reach 35%, stands 12 hours in 0-5 DEG C, filters, filtrate recycling ethanol, it is concentrated into extractum, lyophilization, obtains the dry cream of Chinese medicine；
Mix homogeneously after broken with the Chinese medicine dried cream powder of (2) gained to (1), make the pharmaceutical preparation of the present invention according to galenic pharmacy routine techniques.The present embodiment granule every bag contains crude drug 2.5g.
Claims (10)
1. the pharmaceutical preparation treating recurrent abortion, it is characterised in that by Radix Rehmanniae Preparata, Herba Caraganae intermediae, Fructus Ligustri Lucidi, Folium Ilicis Cornutae, the Radix Paeoniae Alba, Herba Cistanches, fringe dried tuber, Rhizoma Imperatae, Rhizoma Dioscoreae, Rhizoma Cyperi, Radix Stellariae Yunnanensis ten medicinal raw material elaborate simply.
2. pharmaceutical preparation as claimed in claim 1, it is characterised in that be made up of the medicinal raw material of following weight: Radix Rehmanniae Preparata 10-15 part, Herba Caraganae intermediae 12-17 part, Fructus Ligustri Lucidi 15-20 part, Folium Ilicis Cornutae 10-15 part, Radix Paeoniae Alba 7-12 part, Herba Cistanches 4-7 part, fringe dried tuber 8-13 part, Rhizoma Imperatae 7-12 part, Rhizoma Dioscoreae 20-26 part, Rhizoma Cyperi 7-12 part, Radix Stellariae Yunnanensis 15-20 part.
3. pharmaceutical preparation as claimed in claim 2, it is characterised in that be made up of the medicinal raw material of following weight: Radix Rehmanniae Preparata 12 parts, Herba Caraganae intermediae 15 parts, Fructus Ligustri Lucidi 18 parts, Folium Ilicis Cornutae 12 parts, the Radix Paeoniae Alba 8 parts, Herba Cistanches 5 parts, fringe dried tuber 10 parts, Rhizoma Imperatae 10 parts, Rhizoma Dioscoreae 25 parts, Rhizoma Cyperi 8 parts, Radix Stellariae Yunnanensis 15 parts.
4. the pharmaceutical preparation as described in as arbitrary in claim 1-3, it is characterised in that its preparation method comprises the steps:
(1) Herba Caraganae intermediae, the Radix Paeoniae Alba, fringe dried tuber, Rhizoma Cyperi are pulverized, with 65-70% alcohol reflux 1-3 time, united extraction liquid, concentrating under reduced pressure obtains rare extractum, upper polyamide column, first with pure water be eluted to effluent colourless after use 90% ethanol elution again, collecting ethanol elution, decompression recycling ethanol is to without alcohol taste, continuing to be concentrated into extractum, lyophilization, obtains the dry cream of Chinese medicine；
(2) by Radix Rehmanniae Preparata, Fructus Ligustri Lucidi, Folium Ilicis Cornutae, Herba Cistanches, Rhizoma Imperatae, Rhizoma Dioscoreae, Radix Stellariae Yunnanensis boiling secondary, add water into medical material weight portion 4-10 times for the first time, decoct 1.0-1.5 hour, add water as medical material weight portion 3-8 times of second time decocts 1.0-1.5 hour, collecting decoction, filter, filtrate reduced in volume to relative density is 1.03-1.08 (60 DEG C record), adding ethanol makes alcohol content reach 35%, stands 12 hours in 0-5 DEG C, filters, filtrate recycling ethanol, it is concentrated into extractum, lyophilization, obtains the dry cream of Chinese medicine；
Doing active component by mixing homogeneously after broken with the Chinese medicine dried cream powder of (2) gained to (1), this active component individually or mixes with pharmaceutically acceptable carrier, makes the pharmaceutical preparation of the present invention according to galenic pharmacy routine techniques.
5. the arbitrary described pharmaceutical preparation of claim 1-4, it is characterised in that described pharmaceutical preparation is preferably made as peroral dosage form.
6. the pharmaceutical preparation described in claim 5, it is characterised in that described peroral dosage form is dispersant, tablet, film coated tablet, enteric coated tablet, capsule, hard capsule, soft capsule, oral liquid, granule, honey pill agent, powder, sublimed preparation, solution etc..
7. the pharmaceutical preparation described in claim 6, it is characterised in that described peroral dosage form is preferably capsule, tablet, granule.
8. pharmaceutical preparation as claimed in claim 7, it is characterised in that described peroral dosage form is preferably capsule.
9. the arbitrary described pharmaceutical preparation of claim 1-3 lacks the purposes in the medicine causing recurrent abortion at preparation treatment blocking antibody.
10. the arbitrary described pharmaceutical preparation of claim 1-3 lacks the purposes in the medicine causing recurrent abortion syndrome of endogenous heat due to yin deficiency at preparation treatment blocking antibody.
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| CN201610147154.2A CN105796944A (en) | 2016-03-15 | 2016-03-15 | Pharmaceutical preparation for treating recurrent abortion |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103585526A (en) * | 2013-11-27 | 2014-02-19 | 许伟 | Traditional Chinese medicine for abortion prevention |
| CN104491357A (en) * | 2014-12-28 | 2015-04-08 | 李宏良 | Traditional Chinese medicine composition as well as preparation method and application thereof |
| CN104510970A (en) * | 2014-12-02 | 2015-04-15 | 广东聚智诚科技有限公司 | Use of traditional Chinese medicine preparation in preparation of drug for treatment of habitual abortion |
| CN104721474A (en) * | 2015-04-17 | 2015-06-24 | 王雪雁 | Traditional Chinese medicinal preparation for treating habitual abortion and preparation method of traditional Chinese medicinal preparation |
| CN108339082A (en) * | 2018-05-15 | 2018-07-31 | 公安县中医医院 | A kind of traditional Chinese herbal decoction for treating threatened abortion |
-
2016
- 2016-03-15 CN CN201610147154.2A patent/CN105796944A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103585526A (en) * | 2013-11-27 | 2014-02-19 | 许伟 | Traditional Chinese medicine for abortion prevention |
| CN104510970A (en) * | 2014-12-02 | 2015-04-15 | 广东聚智诚科技有限公司 | Use of traditional Chinese medicine preparation in preparation of drug for treatment of habitual abortion |
| CN104491357A (en) * | 2014-12-28 | 2015-04-08 | 李宏良 | Traditional Chinese medicine composition as well as preparation method and application thereof |
| CN104721474A (en) * | 2015-04-17 | 2015-06-24 | 王雪雁 | Traditional Chinese medicinal preparation for treating habitual abortion and preparation method of traditional Chinese medicinal preparation |
| CN108339082A (en) * | 2018-05-15 | 2018-07-31 | 公安县中医医院 | A kind of traditional Chinese herbal decoction for treating threatened abortion |
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