CN1726991A - Medication of treating by dysenorrhea, irregular menses, weakness after childbirth for women, and preparation method - Google Patents
Medication of treating by dysenorrhea, irregular menses, weakness after childbirth for women, and preparation method Download PDFInfo
- Publication number
- CN1726991A CN1726991A CN 200510088651 CN200510088651A CN1726991A CN 1726991 A CN1726991 A CN 1726991A CN 200510088651 CN200510088651 CN 200510088651 CN 200510088651 A CN200510088651 A CN 200510088651A CN 1726991 A CN1726991 A CN 1726991A
- Authority
- CN
- China
- Prior art keywords
- radix
- parts
- pharmaceutical composition
- rhizoma
- hour
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
A Chinese medicine in the form of oral liquid for treating menalgia, menoxenia, uterine bleeding, morbid leukorrhea, etc is prepared from 19 Chinese-medicinal materials including Taihe chicken, ginseng, antler, Chinese angelica root, etc through conventional process.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, relating in particular to a kind of is the Chinese patent medicine and preparation method thereof of the treatment dysmenorrhes that is prepared from of primary raw material, menoxenia, puerperal asthenia with Gallus Domesticus and Chinese herbal medicine, belongs to the field of Chinese medicines.
Background technology
The women is this with blood, and easy hematozemia during, pregnant, product, breast causes body often to be in insufficiency of blood and state that gas is contained partially.All blood troubles must influence gas, feel frustrated and must involve in blood, and the two is closely related.Generally speaking, cold, hot, wet normal easily blood trouble.Heat then before menstrual period, too much etc.; Cold then blood clotting, through after, very few, dysmenorrhea, amenorrhea; Wet then viscous is easy to make a bet; Then under the blood, the deficiency of vital energy is blood prostration then, can cause menoxenia for QI collapse caused by exhaustion of QI of the spleen and kidney; The stagnation of QI is blood stasis then, and dysmenorrhea, amenorrhea etc. can appear in blockage of menstruation.This shows that disorder of QI and blood is the important mechanism that causes gynaecopathia.
Because the quickening of modern life rhythm, the pressure of working and learning is increasing, and especially the women is undertaking increasing role in the modern life, women's self physiological reason causes the women weak blood deficiency, menoxenia to occur in addition, menalgia, leukorrhagia, few abdomen cold type of pain, weak weak, waist soreness, puerperal asthenia, the ratio of symptoms such as night sweat due to yin deficiency more raises, according to sampling survey in recent years, this sick sickness rate is up to 89%.
The general traditional Chinese medical science is used the invigorating the spleen and replenishing QI pill for curing for the menoxenia that the deficiency of vital energy causes; For interior-heat caused by deficiency of YIN, be the menoxenia that heat in blood causes, with the treatment of two places soup; For the menoxenia that liver-heat causes, then treat with red mast ease pill.It is gynecological's BAIFENG KOUFUYE that the Chinese patent medicine that is used for the treatment of menoxenia in the market also has a kind of, there is certain curative effect in this medicine for menoxenia, but generally speaking, the at present existing Chinese patent medicine that is used for the treatment of menoxenia all in various degree have defectives such as curative effect is definite inadequately.
Summary of the invention
The present invention's technical problem at first to be solved is to overcome the deficiencies in the prior art, and the pharmaceutical composition of a kind of treatment dysmenorrhes evident in efficacy, menoxenia, bleeding not during menses, puerperal asthenia is provided.
The present invention's technical problem at first to be solved realizes by following technological approaches:
A kind of pharmaceutical composition for the treatment of dysmenorrhes, menoxenia, bleeding not during menses, puerperal asthenia, make by the raw material of following weight portion:
Remove Gallus Domesticus 80-160 part, Cornu Cervi 5-20 part, Radix Ginseng 20-40 part, Radix Astragali 1-10 part, Rhizoma Dioscoreae 15-50 part, Radix Angelicae Sinensis 20-60 part, Radix Rehmanniae Preparata 30-80 part, Radix Paeoniae Alba 20-60 part, Rhizoma Chuanxiong 5-40 part, Radix Asparagi 5-30 part, Radix Rehmanniae 30-80 part, Herba Artemisiae Annuae 5-30 part, Radix Stellariae 2-10 part, Ootheca Mantidis 5-20 part, Concha Ostreae 5-20 part, parched with bran Semen Euryales 5-20 part, Radix Salviae Miltiorrhizae 10-60 part, Rhizoma Cyperi (processed with vinegar) 20-50 part, Radix Glycyrrhizae 3-20 part of hair, pawl and intestinal.
More than the weight portion of each raw material be preferably:
128 parts of the Gallus Domesticuss of unhairing, pawl, intestinal, 9.6 parts on Cornu Cervi, 25.6 parts of Radix Ginsengs, 4 parts of the Radixs Astragali, 25.6 parts of Rhizoma Dioscoreaes, 28.8 parts of Radix Angelicae Sinensis, 51.2 parts of Radix Rehmanniae Preparata, 25.6 parts of the Radix Paeoniae Albas, 12.8 parts of Rhizoma Chuanxiongs, 12.8 parts of Radix Asparagis, 51.2 parts of Radix Rehmanniae, 12.9 parts of Herba Artemisiae Annuaes, 4.8 parts of Radix Stellariaes, 9.6 parts of Ootheca Mantidiss, 9.6 parts of Concha Ostreaes, 12.8 parts of parched with bran Semen Euryaless, 25.6 parts of Radix Salviae Miltiorrhizaes, 25.6 parts of Rhizoma Cyperi (processed with vinegar), 6.4 parts in Radix Glycyrrhizae.
In the above-mentioned raw materials, the concocting method of parched with bran Semen Euryales is as follows: rise frying in the wheat bran heat release pot to cigarette earlier, cleaner Semen Euryales is poured into, stir to little yellow, take out, the well sifted wheat bran cools.
The concocting method of Rhizoma Cyperi (processed with vinegar) is as follows: gets clean Rhizoma Cyperi grain (sheet), mixes thoroughly with vinegar, and vexed one night, put and fry in the pot to little yellow, take out, dry (100 jin of every Rhizoma Cyperi grain or sheets are with 20 jin of vinegar).
The compatibility foundation of medicine of the present invention: Gallus Domesticus goes into the Liver and kidney warp in the side, mends menses, liver and kidney tonifying.Have benefiting qi and nourishing blood, be used for married woman's body void, menoxenia, bleeding not during menses, the acid of lumbago lower limb; Radix Astragali invigorating QI to consolidate the body surface resistance, it is weak to be used for the deficiency of vital energy, the metrorrhagia etc. of having blood in stool; Radix Ginseng is used for invigorating primordial QI, and multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, and calms the nerves; Radix Angelicae Sinensis has the effect of tonifying blood and regulating menstruation, promoting blood circulation and stopping pain; Rhizoma Chuanxiong, the Radix Paeoniae Alba have the effect of pain relieving, tonifying blood and regulating menstruation, yin nourishing; Radix Rehmanniae is used to the YIN nourishing of enriching blood; Cornu Cervi is used for invigorating the liver and kidney, benefiting essence-blood; Radix Salviae Miltiorrhizae, Concha Ostreae are used to invigorate blood circulation, eliminating stagnation, YIN nourishing and calm the nerves; Rhizoma Cyperi (processed) then is a QI regulating medicine; Herba Artemisiae Annuae is returned liver, gallbladder meridian, has heat clearing away, removes the effect of steaming, with the Rhizoma Cyperi compatibility, strengthens the function of Rhizoma Cyperi promoting QI circulation for relieving depression, menstruction regulating and pain relieving; Ootheca Mantidis is used for receiving kidney-replenishing; Radix Stellariae has the function of clearind deficient heat; The effect of the yin nourishing of Radix Asparagi tool, nourishing kidney; Rhizoma Dioscoreae spleen reinforcing, yin nourishing, kidney tonifying; Semen Euryales has spleen reinforcing, dry, reinforce the kidney and effect such as leukorrhagia stopping.
The whole compatibility property of medicine is gentle, cold not dry, and each compatibility of drugs complements each other, the treatment of deficiency-syndrome by reinforcement, plays enriching yin and nourishing kidney altogether, benefiting QI and nourishing blood, the effect of adjusting meridian and stopping leukorrhea is for blood deficiency, menoxenia, dysmenorrhea, puerperal asthenia, menalgia a little less than the human female, leukorrhagia, few abdomen cold type of pain, weak weak, waist soreness, puerperal asthenia, all diseases such as night sweat due to yin deficiency all have significant curative effect, are the good medicine of strengthening the body resistance.
When medication preparation of the present invention was become oral liquid or pill, above-mentioned prescription carried out compatible combination as if the Mel (preferred 450 weight portions) with the 100-800 weight portion, can reach better therapeutic effect.
Pharmaceutical composition of the present invention adds various conventional adjuvant required when preparing different dosage form, for example disintegrating agent, lubricant, adhesive etc., method of Chinese medicinal with routine can be prepared into any suitable oral formulations, can be oral liquid, pill, capsule, tablet, powder or granule etc. for example, be preferably oral liquid.
Preferably, a kind of method for preparing pharmaceutical composition of the present invention, step is as follows:
1) take by weighing each raw material by following weight portion:
Remove Gallus Domesticus 80-160 part, Cornu Cervi 5-20 part, Radix Ginseng 20-40 part, Radix Astragali 1-10 part, Rhizoma Dioscoreae 15-50 part, Radix Angelicae Sinensis 20-60 part, Radix Rehmanniae Preparata 30-80 part, Radix Paeoniae Alba 20-60 part, Rhizoma Chuanxiong 5-40 part, Radix Asparagi 5-30 part, Radix Rehmanniae 30-80 part, Herba Artemisiae Annuae 5-30 part, Radix Stellariae 2-10 part, Ootheca Mantidis 5-20 part, Concha Ostreae 5-20 part, parched with bran Semen Euryales 5-20 part, Radix Salviae Miltiorrhizae 10-60 part, Rhizoma Cyperi (processed with vinegar) 20-50 part, Radix Glycyrrhizae 3-20 part of hair, pawl and intestinal.
2) will remove the 13 flavor raw material blendings such as Gallus Domesticus, Cornu Cervi, Radix Ginseng, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Asparagi, Herba Artemisiae Annuae, Ootheca Mantidis, Concha Ostreae, Radix Salviae Miltiorrhizae, Rhizoma Cyperi (processed with vinegar) and Radix Glycyrrhizae of hair, pawl and intestinal, and add the equivalent yellow wine and steamed 18-30 hour;
3) with Six-element mixings such as the medical material after the above-mentioned steaming and the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Chuanxiong, Radix Rehmanniae, Radix Stellariae, Semen Euryaless, decoct with water, decocting liquid is filtered, filtrate is concentrated into relative density 1.02-1.15, and temperature is 50 ℃, cold preservation;
4) filtrate after the cold preservation filters once more, and filtrate being heated to boiled, and adds Mel, and potassium sorbate adds water then, stirs evenly, and the supernatant embedding is drawn in cold preservation, sterilization, promptly.
In the above-mentioned preparation method, wherein decoct with water in the step 3) three times, decocted 1-2 hour for the first time, decocted 0.5-1.5 hour for the second time, decocted collecting decoction for the third time 0.5-1.5 hour.
Usage and consumption: the dosage of medicine of the present invention depends on concrete dosage form, factors such as patient's age, body weight, health status.As guidance: oral liquid, oral, a 10ml, 2 times on the one, 2 weeks were a course of treatment.
The specific embodiment
Further describe the present invention by the following examples, it should be understood that these embodiment only are used for the purpose of illustration, never limit the scope of the invention.
The preparation of [embodiment 1] oral liquid
Take by weighing each raw material by following weight:
The Gallus Domesticus 128g Cornu Cervi 9.6g of unhairing, pawl, intestinal
Radix Ginseng 25.6g Radix Astragali 4g
Rhizoma Dioscoreae 25.6g Radix Angelicae Sinensis 28.8g
Radix Rehmanniae Preparata 51.2g Radix Paeoniae Alba 25.6g
Rhizoma Chuanxiong 12.8g Radix Asparagi 12.8g
Radix Rehmanniae 51.2g Herba Artemisiae Annuae 12.9g
Radix Stellariae 4.8g Ootheca Mantidis 9.6g
Concha Ostreae 9.6g parched with bran Semen Euryales 12.8g
Radix Salviae Miltiorrhizae 25.6g Rhizoma Cyperi (processed with vinegar) 25.6g
Radix Glycyrrhizae 6.4g;
Except that the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Chuanxiong, Radix Rehmanniae, Radix Stellariae, Semen Euryales, 13 flavor mixings such as all the other Gallus Domesticuss are put in the jar, add the equivalent yellow wine and steam 24 hours.Six-element medicine mixings such as the medical material after the steaming and the above-mentioned Radix Astragali decoct with water three times, and 1.5 hours for the first time, 1 hour for the second time, 1 hour for the third time, collecting decoction filtered, filtrate is concentrated into relative density 1.10 (50 ℃), and cold preservation 24 hours filters, filtrate being heated to boiled, and adds Mel 450g, potassium sorbate 1.5g, add water to 1000m1 then, stir evenly, cold preservation 48 hours, draw the supernatant embedding, sterilization, promptly.
The preparation of [embodiment 2] oral liquid
Take by weighing each raw material by following weight:
Unhairing, pawl, intestinal Gallus Domesticus 80g Cornu Cervi 5g
Radix Ginseng 20g Radix Astragali 1g
Rhizoma Dioscoreae 15g Radix Angelicae Sinensis 20g
Radix Rehmanniae Preparata 30g Radix Paeoniae Alba 20g
Rhizoma Chuanxiong 5g Radix Asparagi 5g
Radix Rehmanniae 30g Herba Artemisiae Annuae 5g
Radix Stellariae 2g Ootheca Mantidis 5g
Concha Ostreae 5g parched with bran Semen Euryales 5g
Radix Salviae Miltiorrhizae 10g Rhizoma Cyperi (processed with vinegar) 20g
Radix Glycyrrhizae 3g;
Except that the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Chuanxiong, Radix Rehmanniae, Radix Stellariae, Semen Euryales, 13 flavor mixings such as all the other Gallus Domesticuss are put in the jar, add the equivalent yellow wine and steam 24 hours.Six-element medicine mixings such as the medical material after the steaming and the above-mentioned Radix Astragali decoct with water three times, and 1 hour for the first time, 0.5 hour for the second time, 0.5 hour for the third time, collecting decoction filtered, filtrate is concentrated into relative density 1.02 (50 ℃), and cold preservation 24 hours filters, filtrate being heated to boiled, and adds Mel 150g, potassium sorbate 1g, add water to 1000ml then, stir evenly, cold preservation 48 hours, draw the supernatant embedding, sterilization, promptly.
The preparation of [embodiment 3] oral liquid
Take by weighing each raw material by following weight:
The Gallus Domesticus 160g Cornu Cervi 20g of unhairing, pawl, intestinal
Radix Ginseng 40g Radix Astragali 10g
Rhizoma Dioscoreae 50g Radix Angelicae Sinensis 60g
Radix Rehmanniae Preparata 80g Radix Paeoniae Alba 60g
Rhizoma Chuanxiong 40g Radix Asparagi 30g
Radix Rehmanniae 80g Herba Artemisiae Annuae 30g
Radix Stellariae 10g Ootheca Mantidis 20g
Concha Ostreae 20g parched with bran Semen Euryales 20g
Radix Salviae Miltiorrhizae 60g Rhizoma Cyperi (processed with vinegar) 50g
Radix Glycyrrhizae 20g;
Except that the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Chuanxiong, Radix Rehmanniae, Radix Stellariae, Semen Euryales, 13 flavor mixings such as all the other Gallus Domesticuss are put in the jar, add the equivalent yellow wine and steam 24 hours.Six-element medicine mixings such as the medical material after the steaming and the above-mentioned Radix Astragali decoct with water three times, and 2 hours for the first time, 1.5 hours for the second time, 1.5 hours for the third time, collecting decoction filtered, filtrate is concentrated into relative density 1.15 (50 ℃), and cold preservation 24 hours filters, filtrate being heated to boiled, and adds Mel 750g, potassium sorbate 2g, add water 1000ml then, stir evenly, cold preservation 48 hours, draw the supernatant embedding, sterilization, promptly.
The preparation of [embodiment 4] capsule
The Gallus Domesticus 128g Cornu Cervi 9.6g of unhairing, pawl, intestinal
Radix Ginseng 25.6g Radix Astragali 4g
Rhizoma Dioscoreae 25.6g Radix Angelicae Sinensis 28.8g
Radix Rehmanniae Preparata 51.2g Radix Paeoniae Alba 25.6g
Rhizoma Chuanxiong 12.8g Radix Asparagi 12.8g
Radix Rehmanniae 51.2g Herba Artemisiae Annuae 12.9g
Radix Stellariae 4.8g Ootheca Mantidis 9.6g
Concha Ostreae 9.6g parched with bran Semen Euryales 12.8g
Radix Salviae Miltiorrhizae 25.6g Rhizoma Cyperi (processed with vinegar) 25.6g
Radix Glycyrrhizae 6.4g;
Except that the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Chuanxiong, Radix Rehmanniae, Radix Stellariae, Semen Euryales, 13 flavor mixings such as all the other Gallus Domesticuss are put in the jar, add the equivalent yellow wine and steam 24 hours.Six-element medicine mixings such as the medical material after the steaming and the above-mentioned Radix Astragali decoct with water three times, 1.5 hours for the first time, 1 hour for the second time, 1 hour for the third time, collecting decoction, filter, filtrate is concentrated into relative density 1.10 (50 ℃), adds ethanol and carries out precipitate with ethanol, reclaim ethanol, filtrate is condensed into the extractum that proportion is 1.20-1.35, adds proper auxiliary materials, mixing, drying is made capsule by this area routine techniques.
The preparation of [embodiment 5] granule
The Gallus Domesticus 128g Cornu Cervi 9.6g of unhairing, pawl, intestinal
Radix Ginseng 25.6g Radix Astragali 4g
Rhizoma Dioscoreae 25.6g Radix Angelicae Sinensis 28.8g
Radix Rehmanniae Preparata 51.2g Radix Paeoniae Alba 25.6g
Rhizoma Chuanxiong 12.8g Radix Asparagi 12.8g
Radix Rehmanniae 51.2g Herba Artemisiae Annuae 12.9g
Radix Stellariae 4.8g Ootheca Mantidis 9.6g
Concha Ostreae 9.6g parched with bran Semen Euryales 12.8g
Radix Salviae Miltiorrhizae 25.6g Rhizoma Cyperi (processed with vinegar) 25.6g
Radix Glycyrrhizae 6.4g;
Except that the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Chuanxiong, Radix Rehmanniae, Radix Stellariae, Semen Euryales, 13 flavor mixings such as all the other Gallus Domesticuss are put in the jar, add the equivalent yellow wine and steam 24 hours.Six-element medicine mixings such as the medical material after the steaming and the above-mentioned Radix Astragali decoct with water three times, 1.5 hours for the first time, 1 hour for the second time, 1 hour for the third time, collecting decoction, filter, filtrate is concentrated into relative density 1.10 (50 ℃), adds ethanol and carries out precipitate with ethanol, reclaim ethanol, filtrate is condensed into the extractum that proportion is 1.20-1.35, adds proper auxiliary materials, mixing, drying is made granule by this area routine techniques.
The preparation of [embodiment 6] pill
The Gallus Domesticus 128g Cornu Cervi 9.6g of unhairing, pawl, intestinal
Radix Ginseng 25.6g Radix Astragali 4g
Rhizoma Dioscoreae 25.6g Radix Angelicae Sinensis 28.8g
Radix Rehmanniae Preparata 51.2g Radix Paeoniae Alba 25.6g
Rhizoma Chuanxiong 12.8g Radix Asparagi 12.8g
Radix Rehmanniae 51.2g Herba Artemisiae Annuae 12.9g
Radix Stellariae 4.8g Ootheca Mantidis 9.6g
Concha Ostreae 9.6g parched with bran Semen Euryales 12.8g
Radix Salviae Miltiorrhizae 25.6g Rhizoma Cyperi (processed with vinegar) 25.6g
Radix Glycyrrhizae 6.4g;
Except that the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Chuanxiong, Radix Rehmanniae, Radix Stellariae, Semen Euryales, 13 flavor mixings such as all the other Gallus Domesticuss are put in the jar, add the equivalent yellow wine and steam 24 hours.Six-element medicine mixings such as the medical material after the steaming and the above-mentioned Radix Astragali decoct with water three times, 1.5 hours for the first time, 1 hour for the second time, 1 hour for the third time, collecting decoction, filter, filtrate is concentrated into relative density 1.10 (50 ℃), adds ethanol and carries out precipitate with ethanol, reclaim ethanol, filtrate is condensed into the extractum that proportion is 1.20-1.35, adds proper auxiliary materials, mixing, drying is made various pills by this area routine techniques.
The preparation of [embodiment 7] tablet
The Gallus Domesticus 128g Cornu Cervi 9.6g of unhairing, pawl, intestinal
Radix Ginseng 25.6g Radix Astragali 4g
Rhizoma Dioscoreae 25.6g Radix Angelicae Sinensis 28.8g
Radix Rehmanniae Preparata 51.2g Radix Paeoniae Alba 25.6g
Rhizoma Chuanxiong 12.8g Radix Asparagi 12.8g
Radix Rehmanniae 51.2g Herba Artemisiae Annuae 12.9g
Radix Stellariae 4.8g Ootheca Mantidis 9.6g
Concha Ostreae 9.6g parched with bran Semen Euryales 12.8g
Radix Salviae Miltiorrhizae 25.6g Rhizoma Cyperi (processed with vinegar) 25.6g
Radix Glycyrrhizae 6.4g;
Except that the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Chuanxiong, Radix Rehmanniae, Radix Stellariae, Semen Euryales, 13 flavor mixings such as all the other Gallus Domesticuss are put in the jar, add the equivalent yellow wine and steam 24 hours.Six-element medicine mixings such as the medical material after the steaming and the above-mentioned Radix Astragali decoct with water three times, 1.5 hours for the first time, 1 hour for the second time, 1 hour for the third time, collecting decoction, filter, filtrate is concentrated into relative density 1.10 (50 ℃), adds ethanol and carries out precipitate with ethanol, reclaim ethanol, filtrate is condensed into the extractum that proportion is 1.20-1.35, adds proper auxiliary materials, mixing, drying is made tablet by this area routine techniques.
Test the clinical observation on the therapeutic effect test of routine pharmaceutical composition of the present invention
One, physical data
Accept out-patient's 101 examples for medical treatment, 17～61 years old age.17～30 years old, 35 examples; 31～40 years old, 32 examples; 41～50 years old, 26 examples; 51～61 years old, 8 examples.Wherein, dysmenorrhea patient 22 examples; Menoxenia patient 23 examples; Bleeding not during menses patient 12 examples; Puerperal asthenia patient 16 examples; Weak weak, waist soreness, night sweat due to yin deficiency patient 12 examples; Dysmenorrhea, menoxenia and bleeding not during menses patient 16 examples.Above patient is divided into treatment group and matched group at random, and wherein 56 examples are organized in treatment, 17～6 years old age, 35 years old mean age; Matched group 45 examples, at 18～61 years old age, 34 years old mean age is from distribution situations such as two groups of ages, the course of disease, the state of an illness, no significant difference, P＞0.05.
Two, trial drug
For the reagent thing: the oral liquid that the embodiment of the invention 1 is prepared.
Control drug: gynecological's BAIFENG KOUFUYE (Baiyunshan Pharmaceutics Stock-sharing Co., Ltd., Guangzhou City).
Three, Therapeutic Method
The treatment group is with for the treatment of reagent thing, and is oral, a 10ml, and 2 times on the one, 2 weeks were a course of treatment, treated 3 courses of treatment altogether.
Matched group is with gynecological's BAIFENG KOUFUYE treatment, and is oral, a 10ml, and 2 times on the one, 2 weeks were a course of treatment, treated 3 courses of treatment altogether.
Four, curative effect determinate standard
1. course of treatment of clinical recovery medication, disappeared with interior clinical symptoms and sign 3 courses of treatment with interior sx, and integration reduces 〉=95%.
2. the produce effects medication obviously improves with interior symptom, Signs a course of treatment, and integration reduces 〉=70%.
3. effectively medication makes moderate progress with interior symptom, sign a course of treatment, and integration reduces 〉=30%.
4. invalid medication does not have improvement with interior symptom and sign 3 each course of treatment, or integration reduces less than 30%.
Four, observed result
Observed result sees Table 1.
Table 1 pharmaceutical composition clinical observation on the therapeutic effect of the present invention result
Clinical recovery produce effects enabledisable cure rate total effective rate
36 examples, 11 examples, 9 examples 64.2% 100% are organized in treatment
Matched group 27 examples 9 examples 5 examples 4 examples 60.0% 91.1%
Observed result shows, pharmaceutical composition of the present invention is for menoxenia, menalgia, and bleeding not during menses, few abdomen cold type of pain, weak weak, waist soreness, puerperal asthenia, diseases such as night sweat due to yin deficiency all have significant curative effect, and clinical efficacy is better than the positive control medicine.
Claims (10)
1. pharmaceutical composition for the treatment of dysmenorrhes, menoxenia, bleeding not during menses, puerperal asthenia, make by the raw material of following weight portion:
Remove Gallus Domesticus 80-160 part, Cornu Cervi 5-20 part, Radix Ginseng 20-40 part, Radix Astragali 1-10 part, Rhizoma Dioscoreae 15-50 part, Radix Angelicae Sinensis 20-60 part, Radix Rehmanniae Preparata 30-80 part, Radix Paeoniae Alba 20-60 part, Rhizoma Chuanxiong 5-40 part, Radix Asparagi 5-30 part, Radix Rehmanniae 30-80 part, Herba Artemisiae Annuae 5-30 part, Radix Stellariae 2-10 part, Ootheca Mantidis 5-20 part, Concha Ostreae 5-20 part, parched with bran Semen Euryales 5-20 part, Radix Salviae Miltiorrhizae 10-60 part, Rhizoma Cyperi (processed with vinegar) 20-50 part, Radix Glycyrrhizae 3-20 part of hair, pawl and intestinal.
2. according to the pharmaceutical composition of claim 1, it is characterized in that the weight portion of each raw material is:
128 parts of the Gallus Domesticuss of unhairing, pawl, intestinal, 9.6 parts on Cornu Cervi, 25.6 parts of Radix Ginsengs, 4 parts of the Radixs Astragali, 25.6 parts of Rhizoma Dioscoreaes, 28.8 parts of Radix Angelicae Sinensis, 51.2 parts of Radix Rehmanniae Preparata, 25.6 parts of the Radix Paeoniae Albas, 12.8 parts of Rhizoma Chuanxiongs, 12.8 parts of Radix Asparagis, 51.2 parts of Radix Rehmanniae, 12.9 parts of Herba Artemisiae Annuaes, 4.8 parts of Radix Stellariaes, 9.6 parts of Ootheca Mantidiss, 9.6 parts of Concha Ostreaes, 12.8 parts of parched with bran Semen Euryaless, 25.6 parts of Radix Salviae Miltiorrhizaes, 25.6 parts of Rhizoma Cyperi (processed with vinegar), 6.4 parts in Radix Glycyrrhizae.
3. according to the pharmaceutical composition of claim 1 or 2, it is characterized in that also containing the Mel of 100-800 weight portion.
4. according to the pharmaceutical composition of claim 3, the weight portion that it is characterized in that described Mel is 450 parts.
5. according to the pharmaceutical composition of claim 1 or 2, it is characterized in that described pharmaceutical composition is prepared into oral formulations according to the conventional formulation method of the field of Chinese medicines.
6. according to the pharmaceutical composition of claim 5, it is characterized in that described oral formulations is oral liquid, pill, capsule, tablet, powder or granule.
7. according to the pharmaceutical composition of claim 6, it is characterized in that described oral formulations is an oral liquid.
8. a method for preparing the pharmaceutical composition of claim 1 may further comprise the steps;
1) with following 13 flavor raw material blendings: remove Gallus Domesticus, Cornu Cervi, Radix Ginseng, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Asparagi, Herba Artemisiae Annuae, Ootheca Mantidis, Concha Ostreae, Radix Salviae Miltiorrhizae, Rhizoma Cyperi (processed with vinegar) and the Radix Glycyrrhizae of hair, pawl and intestinal, mixture adds the equivalent yellow wine and steamed 18-30 hour;
2) with the medical material after the above-mentioned steaming and the Radix Astragali, Rhizoma Dioscoreae, Rhizoma Chuanxiong, Radix Rehmanniae, Radix Stellariae and Semen Euryales mixing, decoct with water, decocting liquid is filtered, filtrate is concentrated into relative density 1.02-1.15, and temperature is 50 ℃, cold preservation;
3) filtrate after the cold preservation filters once more, and filtrate being heated to boiled, and adds Mel, and potassium sorbate adds water then, stirs evenly, and the supernatant embedding is drawn in cold preservation, sterilization, promptly.
9. according to the method for claim 8, it is characterized in that step 2) in decoct with water three times, decocted 1-2 hour for the first time, decocted 0.5-1.5 hour for the second time, fried in shallow oil collecting decoction for the third time 0.5-1.5 hour.
10. each pharmaceutical composition of claim 1-7 is in preparation treatment menoxenia, dysmenorrhea, bleeding not during menses, puerperal asthenia, weak weak, the purposes in waist soreness or the night sweat due to yin deficiency medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510088651 CN1726991A (en) | 2005-07-29 | 2005-07-29 | Medication of treating by dysenorrhea, irregular menses, weakness after childbirth for women, and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510088651 CN1726991A (en) | 2005-07-29 | 2005-07-29 | Medication of treating by dysenorrhea, irregular menses, weakness after childbirth for women, and preparation method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1726991A true CN1726991A (en) | 2006-02-01 |
Family
ID=35926629
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200510088651 Pending CN1726991A (en) | 2005-07-29 | 2005-07-29 | Medication of treating by dysenorrhea, irregular menses, weakness after childbirth for women, and preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1726991A (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101940609A (en) * | 2010-07-19 | 2011-01-12 | 李君� | Medicinal liquor for treating dysmenorrhea |
| CN102771815A (en) * | 2012-07-13 | 2012-11-14 | 安徽富煌三珍食品集团有限公司 | Nourished mullet and black-bone chicken meat slice and making method thereof |
| CN101757354B (en) * | 2008-12-11 | 2013-04-10 | 董根荣 | Medicament composition for treating dysmenorrhea and preparation method thereof |
| CN103494991A (en) * | 2013-09-25 | 2014-01-08 | 孙桂臻 | Traditional Chinese medicine preparation for treating female metrorrhagia and preparation method thereof |
| CN104587166A (en) * | 2015-02-08 | 2015-05-06 | 杜兆君 | Traditional Chinese medicine preparation for treating postpartum, and preparation method |
| CN105250728A (en) * | 2015-11-16 | 2016-01-20 | 覃淑兰 | Chinese herbal preparation for treating irregular menstruation and preparation method thereof |
| CN108066571A (en) * | 2017-12-28 | 2018-05-25 | 湖州品创孵化器有限公司 | A kind of White Phoenix Bolus of Black-bone Chicken and its preparation process |
| CN116407593A (en) * | 2021-12-29 | 2023-07-11 | 北京同仁堂股份有限公司 | Application of pharmaceutical composition in preparation of medicines for preventing or treating alcoholic liver disease |
-
2005
- 2005-07-29 CN CN 200510088651 patent/CN1726991A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757354B (en) * | 2008-12-11 | 2013-04-10 | 董根荣 | Medicament composition for treating dysmenorrhea and preparation method thereof |
| CN101940609A (en) * | 2010-07-19 | 2011-01-12 | 李君� | Medicinal liquor for treating dysmenorrhea |
| CN102771815A (en) * | 2012-07-13 | 2012-11-14 | 安徽富煌三珍食品集团有限公司 | Nourished mullet and black-bone chicken meat slice and making method thereof |
| CN102771815B (en) * | 2012-07-13 | 2013-11-06 | 安徽富煌三珍食品集团有限公司 | Nourished mullet and black-bone chicken meat slice and making method thereof |
| CN103494991A (en) * | 2013-09-25 | 2014-01-08 | 孙桂臻 | Traditional Chinese medicine preparation for treating female metrorrhagia and preparation method thereof |
| CN103494991B (en) * | 2013-09-25 | 2015-02-25 | 孙桂臻 | Traditional Chinese medicine preparation for treating female metrorrhagia and preparation method thereof |
| CN104587166A (en) * | 2015-02-08 | 2015-05-06 | 杜兆君 | Traditional Chinese medicine preparation for treating postpartum, and preparation method |
| CN105250728A (en) * | 2015-11-16 | 2016-01-20 | 覃淑兰 | Chinese herbal preparation for treating irregular menstruation and preparation method thereof |
| CN108066571A (en) * | 2017-12-28 | 2018-05-25 | 湖州品创孵化器有限公司 | A kind of White Phoenix Bolus of Black-bone Chicken and its preparation process |
| CN116407593A (en) * | 2021-12-29 | 2023-07-11 | 北京同仁堂股份有限公司 | Application of pharmaceutical composition in preparation of medicines for preventing or treating alcoholic liver disease |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1299754C (en) | Medicinal composition for treating theumalism and rheumatism diseases | |
| CN1726991A (en) | Medication of treating by dysenorrhea, irregular menses, weakness after childbirth for women, and preparation method | |
| CN1915399A (en) | Preparation for treating high blood pressure, high blood fat, obesity, and climacteric syndrome, and preparation method | |
| CN1167454C (en) | Chinese medicine for detoxication purpose and its preparing process | |
| CN1559576A (en) | Chinese herbal medicine prescription for treating liver cancer, lung cancer, blood cancer, stomach cancer and cardia cancer and its formulating method | |
| CN1457848A (en) | Black-bone chicken white phoenix preparation medicine and its preparing method | |
| CN1131064C (en) | Yang-strengthening and kidney-invigorating medicine and is prepn | |
| CN1285374C (en) | Medicine for treating stomachache caused by qi and cold stagnation and technique for preparing the same | |
| CN1565553A (en) | Dysmenorrhea treating Chinese traditional medicine | |
| CN1297291C (en) | Medicine for abstaining from drug addiction and its preparation | |
| CN1868535A (en) | Medicine composition for treating rheumatic arthritis and rheumatoid arthritis, and its prepn. method | |
| CN1052163C (en) | Chinese patent medicine for curing gallstones and kidney stones | |
| CN1049339C (en) | Chinese drug tumour removing powder and its preparation | |
| CN1255154C (en) | Deer's fetus granular Chinese madicinal preparation and its production technology | |
| CN1850234A (en) | Funingkang thin-coating tablet and preparing method | |
| CN1111043C (en) | Medicine for protrusion of lumber vertebral disc and its preparation | |
| CN1232279C (en) | Antilipemic Chinese medicine | |
| CN1899590A (en) | Gynecological Chinese patented medicine for relieving depressed liver and clearing heat, strengthening spleen and nourishing blood and its preparing method | |
| CN1237443A (en) | Medicine for curing rheumatic heart disease | |
| CN1173715C (en) | Medicine pill for preventing and treating pathological seaility | |
| CN1162166C (en) | Traditional Chinese medicine preparation for regulating adolescence course and improving bone growth of sexual precocity child | |
| CN100342901C (en) | Chinese medicinal composition for treating diabetes, its preparation method and use | |
| CN101036753A (en) | Health-care wine of Chinese traditional medicine and making method thereof | |
| CN1232283C (en) | Chinese drugs for treatment of coronary heart disease and angina pectoris | |
| CN1207012C (en) | Medicine for treating digestive system disease and tumor and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |