CN1255154C - Deer's fetus granular Chinese madicinal preparation and its production technology - Google Patents
Deer's fetus granular Chinese madicinal preparation and its production technology Download PDFInfo
- Publication number
- CN1255154C CN1255154C CNB2004100107166A CN200410010716A CN1255154C CN 1255154 C CN1255154 C CN 1255154C CN B2004100107166 A CNB2004100107166 A CN B2004100107166A CN 200410010716 A CN200410010716 A CN 200410010716A CN 1255154 C CN1255154 C CN 1255154C
- Authority
- CN
- China
- Prior art keywords
- radix
- filtrate
- embryo cervi
- water
- rhizoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 238000005516 engineering process Methods 0.000 title claims description 7
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 241000282994 Cervidae Species 0.000 title abstract description 4
- 210000003754 fetus Anatomy 0.000 title abstract 3
- 239000003814 drug Substances 0.000 claims abstract description 31
- 239000008187 granular material Substances 0.000 claims abstract description 25
- 241000218176 Corydalis Species 0.000 claims abstract description 12
- 210000001161 mammalian embryo Anatomy 0.000 claims description 55
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 44
- 239000000706 filtrate Substances 0.000 claims description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 235000021419 vinegar Nutrition 0.000 claims description 18
- 239000000052 vinegar Substances 0.000 claims description 18
- 241000208340 Araliaceae Species 0.000 claims description 16
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 16
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 16
- 235000008434 ginseng Nutrition 0.000 claims description 16
- 210000001015 abdomen Anatomy 0.000 claims description 13
- 239000000843 powder Substances 0.000 claims description 12
- 238000010992 reflux Methods 0.000 claims description 12
- 239000000341 volatile oil Substances 0.000 claims description 12
- 108010052008 colla corii asini Proteins 0.000 claims description 11
- 239000000796 flavoring agent Substances 0.000 claims description 9
- 235000019634 flavors Nutrition 0.000 claims description 9
- 229920000858 Cyclodextrin Polymers 0.000 claims description 8
- 239000001116 FEMA 4028 Substances 0.000 claims description 8
- 210000004381 amniotic fluid Anatomy 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 8
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 8
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 8
- 229960004853 betadex Drugs 0.000 claims description 8
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 7
- 210000000582 semen Anatomy 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 229920001353 Dextrin Polymers 0.000 claims description 4
- 239000004375 Dextrin Substances 0.000 claims description 4
- 108010010803 Gelatin Proteins 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
- 210000000988 bone and bone Anatomy 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
- 235000019425 dextrin Nutrition 0.000 claims description 4
- 238000004821 distillation Methods 0.000 claims description 4
- 229920000159 gelatin Polymers 0.000 claims description 4
- 239000008273 gelatin Substances 0.000 claims description 4
- 235000019322 gelatine Nutrition 0.000 claims description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims description 4
- 210000001006 meconium Anatomy 0.000 claims description 4
- 238000004064 recycling Methods 0.000 claims description 4
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 4
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 4
- 238000003809 water extraction Methods 0.000 claims description 4
- 238000005303 weighing Methods 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims 1
- 239000008280 blood Substances 0.000 abstract description 32
- 230000000694 effects Effects 0.000 abstract description 32
- 238000011282 treatment Methods 0.000 abstract description 32
- 210000004369 blood Anatomy 0.000 abstract description 31
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 23
- 201000010099 disease Diseases 0.000 abstract description 17
- 208000024891 symptom Diseases 0.000 abstract description 14
- 208000019255 Menstrual disease Diseases 0.000 abstract description 12
- 230000007812 deficiency Effects 0.000 abstract description 12
- 230000005906 menstruation Effects 0.000 abstract description 6
- 230000006870 function Effects 0.000 abstract description 4
- 238000010792 warming Methods 0.000 abstract description 3
- 208000004998 Abdominal Pain Diseases 0.000 abstract description 2
- 206010006895 Cachexia Diseases 0.000 abstract description 2
- 206010067482 No adverse event Diseases 0.000 abstract description 2
- 230000008034 disappearance Effects 0.000 abstract description 2
- 208000026500 emaciation Diseases 0.000 abstract description 2
- 241000411851 herbal medicine Species 0.000 abstract description 2
- 238000012545 processing Methods 0.000 abstract description 2
- 241000427159 Achyranthes Species 0.000 abstract 1
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 244000192528 Chrysanthemum parthenium Species 0.000 abstract 1
- 235000000604 Chrysanthemum parthenium Nutrition 0.000 abstract 1
- 244000150195 Cyperus longus Species 0.000 abstract 1
- 235000018109 Cyperus longus Nutrition 0.000 abstract 1
- 244000075634 Cyperus rotundus Species 0.000 abstract 1
- 241000123589 Dipsacus Species 0.000 abstract 1
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 1
- 235000000802 Leonurus cardiaca ssp. villosus Nutrition 0.000 abstract 1
- 244000241838 Lycium barbarum Species 0.000 abstract 1
- 235000015459 Lycium barbarum Nutrition 0.000 abstract 1
- 235000015468 Lycium chinense Nutrition 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 235000002789 Panax ginseng Nutrition 0.000 abstract 1
- 244000248825 Peltandra virginica Species 0.000 abstract 1
- 235000001188 Peltandra virginica Nutrition 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 240000007164 Salvia officinalis Species 0.000 abstract 1
- 235000005010 Scirpus paludosus Nutrition 0.000 abstract 1
- 241000270708 Testudinidae Species 0.000 abstract 1
- 210000003056 antler Anatomy 0.000 abstract 1
- 238000013329 compounding Methods 0.000 abstract 1
- 239000003292 glue Substances 0.000 abstract 1
- 201000005630 leukorrhea Diseases 0.000 abstract 1
- 235000005412 red sage Nutrition 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 206010046901 vaginal discharge Diseases 0.000 abstract 1
- 230000027758 ovulation cycle Effects 0.000 description 24
- 206010013935 Dysmenorrhoea Diseases 0.000 description 20
- 208000005171 Dysmenorrhea Diseases 0.000 description 17
- 230000003111 delayed effect Effects 0.000 description 14
- 210000003734 kidney Anatomy 0.000 description 13
- 208000007106 menorrhagia Diseases 0.000 description 13
- 208000002193 Pain Diseases 0.000 description 12
- 229940079593 drug Drugs 0.000 description 9
- 230000010354 integration Effects 0.000 description 7
- 230000003821 menstrual periods Effects 0.000 description 7
- 206010000087 Abdominal pain upper Diseases 0.000 description 6
- 210000004185 liver Anatomy 0.000 description 6
- 238000011084 recovery Methods 0.000 description 6
- 208000011580 syndromic disease Diseases 0.000 description 6
- 230000001225 therapeutic effect Effects 0.000 description 6
- 239000002775 capsule Substances 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 241000721047 Danaus plexippus Species 0.000 description 4
- 210000001367 artery Anatomy 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 4
- 230000018044 dehydration Effects 0.000 description 4
- 238000006297 dehydration reaction Methods 0.000 description 4
- 210000003462 vein Anatomy 0.000 description 4
- 208000002173 dizziness Diseases 0.000 description 3
- 230000002607 hemopoietic effect Effects 0.000 description 3
- 230000002175 menstrual effect Effects 0.000 description 3
- 231100000915 pathological change Toxicity 0.000 description 3
- 230000036285 pathological change Effects 0.000 description 3
- 239000002304 perfume Substances 0.000 description 3
- 235000013599 spices Nutrition 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 206010009866 Cold sweat Diseases 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 206010003549 asthenia Diseases 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 210000000629 knee joint Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- -1 time is 5 hours Substances 0.000 description 2
- 210000004291 uterus Anatomy 0.000 description 2
- 206010013908 Dysfunctional uterine bleeding Diseases 0.000 description 1
- 201000009273 Endometriosis Diseases 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010024419 Libido decreased Diseases 0.000 description 1
- 208000029082 Pelvic Inflammatory Disease Diseases 0.000 description 1
- 206010034568 Peripheral coldness Diseases 0.000 description 1
- 208000028017 Psychotic disease Diseases 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 206010046798 Uterine leiomyoma Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 206010000210 abortion Diseases 0.000 description 1
- 231100000176 abortion Toxicity 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000002513 anti-ovulatory effect Effects 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000000157 blood function Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 230000035606 childbirth Effects 0.000 description 1
- 229940121657 clinical drug Drugs 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 238000009499 grossing Methods 0.000 description 1
- 210000000003 hoof Anatomy 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 210000004705 lumbosacral region Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000009247 menarche Effects 0.000 description 1
- 210000004914 menses Anatomy 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000016087 ovulation Effects 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000013077 scoring method Methods 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
- 208000025421 tumor of uterus Diseases 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Abstract
The present invention discloses a traditional Chinese medicine preparation of deer fetus granules, which is prepared by compounding various kinds of natural traditional Chinese medicine of red ginseng, angelica, motherwort herb, prepared radix rehmanniae, nutgrass galingale rhizome, tortoise shell, wolfberry bark, corydalis tuber, white atractylodes rhizome, donkey-hide glue, red sage root, red peony root, himalayan teasel root, chuanxiong rhizome, twotooth achyranthes root, antler, tuckahoe, deer fetus, etc., with scientific processing. The traditional Chinese medicine preparation has the functions of benefiting qi, nourishing blood, warming essence, dissipating cold, etc., and mainly cures various gynecological diseases of deficiency of qi and blood, weakness, emaciation, menoxenia, abdominal pain during menstruation, cold damp leukorrhea, etc. The preparation of the present invention is prepared from pure Chinese herbal medicine, and has the advantages of obvious curative effect, both manifestation and root cause of disease treatment, no adverse reaction, no toxic or side effect, quick disappearance of clinical symptoms and no rebound phenomenon after diseases are cured.
Description
Technical field:
The present invention discloses a kind of Embryo cervi granule Chinese medicine preparation and production technology, relates to treatment of diseases medicines such as menoxenia that insufficiency of vital energy and blood, deficiency of both the liver and kidney cause, dysmenorrhoea, belongs to traditional Chinese medical science pharmaceutical technology field.
Background technology:
Embryo cervi is the good medicine of treatment gynaecopathia as Chinese medicine, clinical for a long time the proof, but use as folk prescription, can not reach the disease treatments such as menoxenia, dysmenorrhoea of best curative effect, particularly gynecological, curative effect is not remarkable, therefore, Embryo cervi has only and other drug matching, and coordinative role could be played curative effect altogether.
Summary of the invention:
The invention provides a kind of Embryo cervi granule Chinese medicine preparation, be the compound composition of multiple medicine, have evident in efficacyly, characteristics such as have no side effect.
The present invention also provides this medicine production technology.
The present invention is the basis according to motherland's traditional Chinese medical science traditional theory, in conjunction with the pathogenesis of gynaecopathia, thinks that after deliberation QI and blood is to keep human life activity's base substance and power, and the married woman is this with blood, and QI and blood is in harmonious proportion, the five internal organs peace and.But because the physiological relation that produces through the band tire, wasting QI-blood decreases its kidney essense, so Embryo cervi is warm in nature in the Embryo cervi side, the function of the kidney tonifying of enriching blood is arranged, Radix Ginseng Rubra sweet in the mouth strongly invigorating primordial QI, and last two distinguish the flavor of Embryo cervi, Radix Ginseng Rubra are monarch, i.e. benefiting qi and nourishing blood, kidney tonifying essence; Married woman such as asthenia of qi and blood decline, then the conception vessel taichong channel declines, and produces all diseases extremely through the band tire, and QI and blood can be supported liter mutually again, QI invigorating is with hemopoietic, the then principle of QI invigorating that nourishes blood, the day after tomorrow is based on taste, and what The spleen has the function to transport and transform nutrients for system blood is dirty, and be the source of hemopoietic, ministerial drug is with the Rhizoma Atractylodis Macrocephalae, Poria invigorating the spleen and benefiting QI, and the basis of dashing a weakness is at kidney, and adding Cornu Cervi Pantotrichum, Carapax et Plastrum Testudinis, Colla Corii Asini, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Radix Dipsaci, Cortex Lycii are medicines such as in love product of flesh and blood and kidney tonifying nourishing kidney sun.Strengthen the enrich blood function of kidney tonifying essence of monarch drug.Blood relies gas capable, and gas is for learning the blood general, on the gas then blood end, because of adding the Radix Aucklandiae, Rhizoma Cyperi, Semen Raphani liver-smoothing, qi-regulating in the side, passages through which vital energy circulates is unobstructed.Again with Herba Leonuri, Radix Salviae Miltiorrhizae, Pollen Typhae, Radix Paeoniae Rubra, Rhizoma Chuanxiong Rhizoma Corydalis promoting blood circulation to disperse blood clots and relieves pain, the pathological changes of lower abdomen is removed has stasis of blood band, QI and blood not smooth, and cold-damp invasion, retention of damp leading to blockage of QI are also arranged, and causes dashing wantonly two arteries and veins imbalance, the uterus deficiency and coldness, walk the product Radix Achyranthis Bidentatae priming of string under behavior adjuvant drug with Cortex Cinnamomi, Fructus Foeniculi, Xin Xiang this moment; The through sick place of dispelling cold by warming the meridian medicine, diseases such as treatment lower abdomen deficiency and coldness dysmenorrhea.Radix Glycyrrhizae, sweet in the mouth coordinating the actions of various ingredients in a prescription and be messenger drug.Though, monarch, minister, help, make compatibility suitable, so clinical efficacy is excellent so we are more.
The all medicine compatibilities of full side's monarch: benefiting qi and nourishing blood, warming essence and spreading cold cure mainly insufficiency of vital energy and blood, and weak win is thin, menoxenia, menalgia, diseases such as cold-damp leukorrhagia.
The present invention selects following medicine component composition by weight for use:
Radix Ginseng Rubra 20-35 part, Radix Angelicae Sinensis 30-50 part, Herba Leonuri 40-65 part,
Radix Rehmanniae Preparata 30-50 part, Rhizoma Cyperi (vinegar system) 10-18 part, Carapax Et Plastrum Testudinis (vinegar system) 5-8 part,
Cortex Lycii 5-10 part, Rhizoma Corydalis (vinegar system) 3-6 part, the Rhizoma Atractylodis Macrocephalae (parched with bran) 6-10 part,
Colla Corii Asini 6-10 part, Radix Salviae Miltiorrhizae 20-35 part, Radix Paeoniae Rubra 8-15 part, Radix Dipsaci 10-18 part,
Rhizoma Chuanxiong 5-10 part, Radix Achyranthis Bidentatae 5-10 part, Cornu Cervi Pantotrichum 3-6 part, Poria 60-100 part,
Embryo cervi (or dehydration Embryo cervi) 50-100 part.
Each amounts of components of medicine of the present invention can also be:
Radix Ginseng Rubra 20-35 part, Radix Angelicae Sinensis 30-50 part, Herba Leonuri 40-65 part,
Radix Rehmanniae Preparata 30-50 part, Rhizoma Cyperi (vinegar system) 10-18 part, Carapax Et Plastrum Testudinis (vinegar system) 5-8 part,
Cortex Lycii 5-10 part, Rhizoma Corydalis (vinegar system) 3-6 part, the Rhizoma Atractylodis Macrocephalae (parched with bran) 6-10 part,
Colla Corii Asini 6-10 part, Radix Salviae Miltiorrhizae 20-35 part, Radix Paeoniae Rubra 8-15 part, Radix Dipsaci 10-18 part,
Rhizoma Chuanxiong 5-10 part, Radix Achyranthis Bidentatae 5-10 part, Cornu Cervi Pantotrichum 3-6 part, Poria 60-100 part,
Embryo cervi (or dehydration Embryo cervi) 50-100 part, Semen Raphani (stir-fry) 5-10 part, Cortex Cinnamomi 3-6 part,
Radix Aucklandiae 3-6 part, Radix Glycyrrhizae 5-10 part, Fructus Foeniculi (processed with salt) 4-8 part, Pollen Typhae 5-10 part.
Optimum ratio of the present invention is:
Radix Ginseng Rubra 31.95g, Radix Angelicae Sinensis 48g, Herba Leonuri 64.05g, Radix Rehmanniae Preparata 48g,
Rhizoma Cyperi (vinegar system) 16.05g, Carapax Et Plastrum Testudinis (vinegar system) 7.95g, Cortex Lycii 7.95g,
Rhizoma Corydalis (vinegar system) 4.8g, Semen Raphani (stir-fry) 7.95g, the Rhizoma Atractylodis Macrocephalae (parched with bran) 9.6g,
Colla Corii Asini 9.6g, Cortex Cinnamomi 4.8g, Radix Aucklandiae 4.8g, Radix Salviae Miltiorrhizae 31.95g,
Radix Paeoniae Rubra 12.75g, Radix Glycyrrhizae 7.95g, Fructus Foeniculi (processed with salt) 6.45g, Radix Dipsaci 16.05g,
Pollen Typhae 7.95g, Rhizoma Chuanxiong 7.95g, Radix Achyranthis Bidentatae 7.95g, Cornu Cervi Pantotrichum 4.8g,
Poria 96g, Embryo cervi (or dehydration Embryo cervi) 86.4g.
Described dehydration Embryo cervi means the normal childbirth of doe young deer of superseded white hoof of putting to death or Aborter, all should be with complete afterbirth.
Concrete processing procedure is as follows:
More than 24 flavors, get Embryo cervi, afterbirth is cut, collect amniotic fluid and put in addition; Peeling off the crust of Embryo cervi puts in addition; Embryo cervi is cut open the belly, remove clean meconium, stripping and slicing, afterbirth is stripping and slicing also, puts altogether in the pot, decocts with water 1～3 time, and each 1-2 hour, amount of water was respectively 10-6 doubly, and to meatization, bone shortcake, gradation filters while hot, merging filtrate; The coat stripping and slicing of Embryo cervi decocts with water 1-3 time, and each 1-2 hour, amount of water was respectively 11-7 doubly, and filtrate merges with above-mentioned filtrate, is concentrated into thickly, and the adding amniotic fluid stirs evenly, and continues to be condensed into paste, and is standby; Radix Ginseng Rubra, Cornu Cervi Pantotrichum, Colla Corii Asini are ground into fine powder, sieve; Rhizoma Cyperi, the Radix Aucklandiae, Fructus Foeniculi, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Rhizoma Chuanxiong add 4-8 times of water extraction volatile oil, and volatile oil is made beta-cyclo dextrin included compound, and the aqueous solution after distillation device is in addition collected, medicinal residues are with the 60-85% alcohol reflux, alcohol adding amount is respectively 8-6 doubly, filters filtrate for later use; Rhizoma Corydalis, Radix Salviae Miltiorrhizae adds 4-8 and doubly measures alcohol reflux, medicinal residues add 2-5 again and doubly measure 70% alcohol reflux, filter, filtrate and aforementioned filtrate merge, and reclaim ethanol, are concentrated into paste, standby, 11 flavors such as medicinal residues and Herba Leonuri decoct with water 2-3 time, and each 1-3 hour, amount of water was respectively 10-6 doubly, gradation filters, merging filtrate adds the aqueous solution after distilling, and being concentrated into relative density is 1.10～1.14 (80 ℃ of surveys), put cold, add ethanol and make and contain the alcohol amount and reach 60-70%, leave standstill, filter, filtrate recycling ethanol, be concentrated into paste, add above-mentioned alcohol-extracted extract, Embryo cervi extractum, Radix Ginseng Rubra, Cornu Cervi Pantotrichum, donkey-hide gelatin fine powder, the volatile oil beta-cyclodextrin inclusion complex, dextrin, the brown sugar fine powder, sodium carboxymethyl cellulose is made granule.This product is faint yellow to brown xanchromatic granule; Feeble QI perfume (or spice), it is sweet to distinguish the flavor of.
[function cures mainly] benefiting qi and nourishing blood, the regulating menstruation cold expelling.Be used for insufficiency of vital energy and blood, weak win is thin, menoxenia, menalgia, cold-damp leukorrhagia.
[usage and dosage] is oral.One time 1 bag, 2 times on the one, be 1 course of treatment, or follow the doctor's advice in one month.
[taboo] anemia of pregnant woman prohibits clothes.
[specification] every packed 10g.
Medicament of the present invention can be a said dosage form on any pharmaceutics, as: granule, capsule, tablet, oral liquid, watered pill, honeyed pill and injection.
Medicine of the present invention is effective in cure to the multiple disease of gynecological, as insufficiency of vital energy and blood, and weak weakness and emaciation, menoxenia, deficiency and coldness dysmenorrhea, diseases such as cold-damp leukorrhagia.
For observing clinical drug curative effect of the present invention and safety, in 97 years 4--8 months, observe 122 examples altogether by Jilin Prov. Inst. of Chinese Medicine and Chinese Medical Science gynecological, attached institute of Changchun Traditional Chinese Medical College, Changchun institute of traditional Chinese medicine, unmarried 124 examples, married 58 examples, age is 88 examples below 20 years old, 21-30 year 67 examples, 27 examples more than 31 years old, student's 101 examples, workman's 34 examples, cadre's 47 examples; The course of disease, 6 months-30 examples (accounting for 16.48%), 1-92 example (accounting for 50.55%), 60 examples more than 3 years (accounting for 32.67%); TCM Syndrome Type: weak type of qi and blood 112 examples (accounting for 61.5%), deficiency of both the liver and kidney type 70 examples (accounting for 38.5%); 27 examples that the state of an illness is slight (accounting for 16.5%), moderate 95 examples (accounting for 52.2%), severe 60 examples (accounting for 32.97%).And do contrast with Embryo cervi capsule 60 examples, observation group's total effective rate 92.62%, matched group total effective rate are 90.00%.
Study subject is selected
1. dysmenorrhea, delayed menstrual cycle, the diagnostic criteria of excessive menstruation disease
1. dysmenorrhea diagnostic criteria
[1]: all menstrual period or through preceding through after (1 week in) occur periodically that hypogastralgia is a primary symptom, with other discomfort and influence work and living reviver.
2. delayed menstrual cycle diagnostic criteria
[2]: menstrual cycle was delayed more than 7 days, and menstrual blood volume is normal substantially, occurred two above persons of menstrual cycle continuously.
3. excessive menstruation disease diagnosis
[3]: menstrual cycle is normal substantially, and through amount showed increased more in the past, or surpasses 100ml through amount, occurs two above persons of menstrual cycle continuously.
2. Chinese medical discrimination
1. dysmenorrhea is dialectical
Deficient qi and blood card: lower abdomen is continuous through the back has a pain, the empty bob of few abdomen and pudendum, and pain relieved by pressing, menstrual blood volume is few, and color is light, and matter is rare clearly, lusterless complexion, spiritlessness and weakness, pale tongue, thready pulse without strength.
Deficiency of both the liver and kidney card: the continuous companion's lumbosacral region of having a pain of lower abdomen is ached in back 1～2 day, and through the color dimness, the few matter of amount is thin, or with dizziness and tinnitus, forgetful insomnia, and hectic fever, body of the tongue is light red, deep pulse or carefully.
2. delayed menstrual cycle, excessive menstruation disease Chinese medical discrimination:
The QI and blood deficiency syndrome: light red through color, matter is thin, spiritlessness and weakness, and deficiency of QI with disinclination to talk, pale complexion, pale tongue is a little less than the deficient and thready pulse.
Deficiency of both the liver and kidney (nephrasthenia syndrome): light dim through color, thin menses, the light dim speckle of color, lumbosacral aching pain, hyposexuality, pale tongue thin fur, deep,thready and forceless pulse.
2. Western medicine diagnose
1. primary dysmenorrhea: gynecologial examination, the adolescent girls in 2～3 years or the young woman of fertility not after the genitals does not have significant organic pathological changes person and betides menarche.
2. menoxenia (delayed menstrual cycle, excessive menstruation disease)
A. ovulation type anovulatory dysfunctional uterine hemorrhage;
B. the menoxenia that causes of edeitis;
C. the in utero menoxenia that causes of birth control and artificial abortion's postoperative.
Three, case inclusion criteria: study subject is drafted by " new Chinese medicine treatment dysmenorrhea, menoxenia clinical research guideline ".
1. include the case standard in: with dysmenorrhea, delayed menstrual cycle, excessive menstruation is primary symptom, and gynecologial examination does not have the significant organic pathological changes and meet the Chinese medical discrimination person.
2. get rid of the case standard:
1. confirm by the dysmenorrhea due to pelvic inflammatory disease, endometriosis, the uterus tumor, menoxenia that hysteromyoma causes through gynecologial examination.2. be associated with the serious primary disease of cardiovascular, liver, kidney and hemopoietic system, psychotic.3. the age was not done the observation case less than 13 years old greater than 45 years old person.
Four, test method
1. grouping: touch the low ball randomized blocks
Observation group's Embryo cervi electuary, every day secondary, each 1 bag (20g), warm boiled water, one month is a course of treatment, finish to judge its curative effect the course of treatment, drug withdrawal is judged total effects after three courses of treatment.
Matched group: the Embryo cervi capsule, every day three times, each 5 capsules are oral, and one month is a course of treatment, finish to judge its curative effect the course of treatment, and total effects is judged in drug withdrawal three courses of treatment.Viewing duration is forbidden other relevant medicine.
2. statistical method: ranked data with test of significance between rank test, measurement data " t " check, paired data, the rate with " X
2" check.
3. observation index: MethodsThe cases enrolled is filled in and is examined (anus is examined) in symptom, sign, blood, routine urinalysis, hepatic and renal function and the gynecological, necessary gynecologial examination project all by observation plan and observe the requirement of table.
Five, result of the test
(1) curative effect determinate standard and foundation thereof
Foundation " new Chinese medicine guideline " is addressed clinical manifestation according to patient's master, adopts scoring method evaluation symptom curative effect.
1. standards of grading score value
(1) menstrual period and front and back lower abdomen pain thereof are 5 minutes
(2) cold and pain in the lower abdomen is 1 minute
(3) the continuous pain of lower abdomen is 1 minute
(4) felt restless 1 fen
(5) pale complexion is 0.5 minute
(6) the cold sweat cold extremities is 1 minute
(7) nausea and vomiting is 2 minutes
(8) spiritlessness and weakness+1 minute, ++ 2 minutes, +++3 minutes
(9) dizziness and blurred vision+1 minute, ++ 2 minutes, +++3 minutes
(10) deficiency of QI with disinclination to talk+1 minute, ++ 2 minutes, +++3 minutes
(11) soreness of waist and knee joint+1 minute, ++ 2 minutes, +++3 minutes
(12) influenced work 1 minute
(13) do not alleviate 1 fen with general pain relieving measure
(14) postponed 0.5 fen with general pain relieving measure pain
The state of an illness is slight: integration 5 minutes-
State of an illness moderate: integration 9 minutes-
State of an illness severe: integration is more than 14 minutes.
2. efficacy determination
1. dysmenorrhea curative effect determinate standard
Recovery from illness: the back stomachache of taking medicine and other transference cures, three menstrual cycle not recidivist's integration were reduced to 0 fen.
Produce effects: stomachache obviously alleviates, and all the other transference cures or alleviate, treatment integration are reduced to below 1/2 of integration before the treatment.Stomachache obviously alleviates, and all the other symptoms take a turn for the better, and the disobedience analgesic can be adhered to work.
Effectively: stomachache alleviates, and other symptoms take a turn for the better, and can adhere to work, and integration is reduced to the 1/2-3/4 before the treatment.Stomachache alleviates, and all the other symptoms take a turn for the better, and the clothes analgesic can be adhered to work.
Invalid: stomachache and other symptoms do not have the changer.
2. delayed menstrual cycle, excessive menstruation disease curative effect determinate standard.
Recovery from illness: menstrual cycle, normal through amount recovery in menstrual period, other transference cure, three menstrual cycle do not recur.
Produce effects: treat the back menstrual cycle, recover normal through amount, menstrual period, other transference cures, three menstrual cycle do not recur.
Effectively: treat back menstrual cycle, improvement before treating in amount, menstrual period, other symptoms alleviate before also treating.
Invalid: treatment back menstrual cycle.Through amount and there is not the improver menstrual period.
(2) efficacy analysis
1. efficacy analysis sees Table 1 between clinical comprehensive therapeutic effect and group.
Curative effect (182 example) between table 1. comprehensive therapeutic effect and group
| The sick kind | Group n | Total effective rate example (%) example (%) example (%) example (%) P (X between recovery from illness produce effects enabledisable group 2) |
| Dysmenorrhea delayed menstrual cycle excessive menstruation | 30 matched groups, 30 observation groups 30 of 62 matched groups, 30 observation groups of observation group | 16(25.80) 20(32.26) 22(35.48) 4(6.45) 93.55 ＞0.05(0.60) 8(26.67) 8(26.67) 11(36.67) 3(10.00) 92.00 11(36.67) 8(26．66) 9(30.00) 2(6.70) 93.33 ＞0.05(0.47) 10(33.33) 7(23.33) 10(33.33) 3(10.00) 90.00 4(13.33) 10(33.33) 13(43.33) 3(10.00) |
Table 1 explanation Embryo cervi granule (electuary) treatment dysmenorrhea, delayed menstrual cycle, excessive menstruation disease have clinical efficacy preferably, and total effective rate is 92.62%, and similar to Embryo cervi capsule curative effect.
Clinical symptoms is improved situation (182 example) before and after table 2. treatment
| Symptom | Group (example) | Before controlling+- | After controlling+- | P (X in the group 2) | P (X between group 2) |
| The continuous dizzy deficiency of QI with disinclination to talk soreness of waist and knee joint of the cold n and V spiritlessness and weakness of pale complexion cold sweat limb of bitterly feeling restless of bellyache in menstrual period cold and pain in the lower abdomen underbelly affects work | Control group observation group of control group observation group of control group observation group of control group observation group of control group observation group of control group observation group of control group observation group of control group observation group of control group observation group of control group observation group of control group observation group of observation group control group | 122 104 60 48 122 74 60 46 122 59 60 25 122 18 60 14 22 41 60 27 122 49 60 27 122 30 60 9 122 99 60 36 122 62 60 25 122 59 60 28 122 86 60 50 122 17 60 8 | 18 35 87 12 15 45 48 14 108 14 11 49 63 25 97 35 8 52 104 0 122 46 0 60 81 1 121 33 1 59 73 4 118 33 9 51 92 3 119 51 1 59 23 59 63 24 19 4l 60 17 105 35 4 56 63 20 102 32 5 55 36 43 79 10 20 40 105 4 118 52 1 59 | ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** ** | ** * * * |
Annotate " * " P＜0.05 " * * " P＜0.01 " " P＞0.05
Relatively be meant the comparison between the two groups of numerals in treatment back between group.
Table 2 prompting Embryo cervi granule (electuary) the clinical symptoms effect that has clear improvement, and curative effect is similar between group.
3. before and after color, matter, amount treatment, change by the moon and see Table 3.
Menstruation color, matter, quantitative changeization (122 example) before and after table 3. treatment
Menstruation color menstruation matter menstrual blood volume
P(X
2) P(X
2) P(X
2)
Dull light red dark red normal thin sticky normal how much normal
Control preceding 30 60 23 9 68 40 14 40 49 33
＜0.01(70.57) ＜0.01(50.43) ＜0.01(41.81)
Control back 10 31 11 70 37 19 66 21 18 83
Menstruation color, matter, amount do not have significant difference (P＜0.01=before X2 check treatment
4. the relation of severity extent and curative effect sees Table 4
The relation of table 4. severity extent and curative effect (122 example)
| Severity extent | Complete | Produce effects | Effectively | Invalid | P |
| Slight (below 9 minutes) moderates (9-) severe (below 14 minutes) | 4 32 13 | 3 31 19 | 7 33 25 | 0 4 11 | ＞0.05 |
Table 4 prompting: through Ridit analyze the state degree and curative effect no significant difference (P＞0.05), Embryo cervi granule (electuary) can be treated various dysmenorrhea and menoxenias in various degree.
5. Embryo cervi granule (electuary) treatment dysmenorrhea, delayed menstrual cycle, menorrhagia, the course of disease and therapeutic effect relationship see Table 5.
Table 5. Embryo cervi granule (electuary) treatment dysmenorrhea, delayed menstrual cycle, menorrhagia, the course of disease and therapeutic effect relationship (122)
| Recovery from illness | Produce effects | Effectively | Invalid | P | |
| 6 months-1 year-3 years- | 4 21 6 | 8 20 10 | 6 20 18 | 2 3 4 | ＞0.05 |
Table 5 illustrates the course of disease and curative effect no significant difference (P＞0.05) through the Ridit check, and dysmenorrhea, delayed menstrual cycle, menorrhagia, course of disease length are all had curative effect preferably.
6. Embryo cervi granule (electuary) treatment dysmenorrhea, delayed menstrual cycle, menorrhagia TCM Syndrome Type and therapeutic effect relationship see Table 6.
Table 6. Embryo cervi granule (electuary) treatment dysmenorrhea, delayed menstrual cycle, menorrhagia, TCM Syndrome Type and therapeutic effect relationship (122 example)
| Recovery from illness | Produce effects | Effectively | Invalid | P(U) | |
| The asthenia of qi and blood Liver and kidney loses | 19 12 | 23 15 | 29 15 | 5 4 | U＝0.06 ＞0.05 |
Table 6 shows Embryo cervi granule (electuary) to above-mentioned disease, and TCM Syndrome Type and curative effect do not have significant difference (P＞0.05).
7. the influence (122 example) of Embryo cervi granule (electuary) tongue arteries and veins
The influence (122 example) of table 7, Embryo cervi granule (electuary) tongue arteries and veins
| Body of the tongue | P(X 2) | Pulse condition | P(X 2) | |||||
| Light | Red | Normally | Empty thin | Heavy thin | Normally | |||
| After controlling before controlling | 65 29 | 53 28 | 4 65 | (75.43) ＜0.01 | 51 20 | 60 34 | 11 68 | (58.44) ＜0.01 |
Table 7 prompting Embryo cervi granule (electuary) is to having notable difference (P＜0.01) before and after the treatment of tongue arteries and veins.
8, the routine blood test variation sees Table 8 before and after the treatment.
RBC, Hb, WBC change (122 example) before and after table 8, the treatment
| Project | Before the treatment (X ± SD) | The treatment back (X ± SD) | t | P |
| RBC Hb WBC | 4.49±0.68 126.06±14.83 7.68±2.20 | 4.68±0.72 133.02±18.46 7.37±1.88 | 2.12 ±4.51 1.04 | ＜0.05 ＜0.01 ＞0.05 |
Table 8 explanation Embryo cervi granule (electuary) has the effect of rising RBC, Hb.
Preparation of the present invention is that pure Chinese herbal medicine is made, and evident in efficacy, treating both the principal and secondary aspects of a disease has no adverse reaction, and has no side effect, and clinical symptom disappearance is rapid, cures the no rebound phenomena in back.
The specific embodiment:
The following example is intended to further describe for example the present invention, rather than limit the present invention by any way, under the prerequisite that does not deviate from the spirit and principles in the present invention, any change or change that those of ordinary skills that the present invention did are realized easily all will fall within the claim scope that awaits the reply of the present invention.
Embodiment 1
Take by weighing Radix Ginseng Rubra 31.95g, Radix Angelicae Sinensis 48g, Herba Leonuri 64.05g, Radix Rehmanniae Preparata 48g, Rhizoma Cyperi (processed with vinegar) 16.05g, Carapax et Plastrum Testudinis(processed with vinegar) 7.95g, Cortex Lycii 7.95g, Rhizoma Corydalis (processed with vinegar) 4.8g, Semen Raphani (parched) 7.95g, Rhizoma Atractylodis Macrocephalae (parched with bran) 9.6g, Colla Corii Asini 9.6g, Cortex Cinnamomi 4.8g, Radix Aucklandiae 4.8g, Radix Salviae Miltiorrhizae 31.95g, Radix Paeoniae Rubra 12.75g, Radix Glycyrrhizae 7.95g, salt Fructus Foeniculi (processed) 6.45g, Radix Dipsaci 16.05g, Pollen Typhae 7.95g, Rhizoma Chuanxiong 7.95g, Radix Achyranthis Bidentatae 7.95g, Cornu Cervi Pantotrichum 4.8g, Poria 96g, Embryo cervi 86.4g.
Get Embryo cervi, afterbirth is cut, collect amniotic fluid and put in addition; Peeling off the crust of Embryo cervi puts in addition.Embryo cervi is cut open the belly, remove clean meconium, stripping and slicing, afterbirth is stripping and slicing also, puts altogether in the pot, decoct with water three times, 2 hours for the first time, second and third time each 1 hour, amount of water is respectively 10,8,6 times, and to meatization, bone shortcake, gradation filters while hot, merging filtrate.The coat stripping and slicing of Embryo cervi decocts with water three times, and 2 hours for the first time, second and third time was respectively 1 hour, amount of water is respectively 11,9,7 times, and gradation filters while hot, and filtrate and above-mentioned filtrate merge, and are concentrated into thick, add amniotic fluid, stir evenly, continue to be condensed into paste, standby; Radix Ginseng Rubra, Cornu Cervi Pantotrichum, Colla Corii Asini are ground into fine powder, sieve; Rhizoma Cyperi, the Radix Aucklandiae, Fructus Foeniculi, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Rhizoma Chuanxiong add 8 times of water extraction volatile oil, time is 5 hours, volatile oil is made beta-cyclo dextrin included compound, aqueous solution after the distillation in addition device is collected, and medicinal residues are with 70% alcohol reflux secondary, each 2 hours, alcohol adding amount is respectively 8,6 times, merge extractive liquid, filters filtrate for later use; Rhizoma Corydalis, Radix Salviae Miltiorrhizae adds 7 times of amount alcohol reflux 3 hours, and medicinal residues add 5 times of amount 70% alcohol reflux 2 hours, merge extractive liquid, again, filter, filtrate and aforementioned filtrate merge, and reclaim ethanol, be concentrated into paste, standby, 11 flavors such as medicinal residues and Herba Leonuri decoct with water secondary, 3 hours for the first time, 2 hours for the second time, amount of water is respectively 10,8 times, gradation filters, merging filtrate, add the aqueous solution after distilling, being concentrated into relative density is 1.10～1.14 (80 ℃ of surveys), puts coldly, adds ethanol and makes and contain the alcohol amount and reach 70%, left standstill 24 hours, filter, filtrate recycling ethanol is concentrated into paste, add above-mentioned alcohol-extracted extract, Embryo cervi extractum, Radix Ginseng Rubra, Cornu Cervi Pantotrichum, donkey-hide gelatin fine powder, the volatile oil beta-cyclodextrin inclusion complex, dextrin, the brown sugar fine powder, sodium carboxymethyl cellulose, make granule 1000g, packing, promptly.This product is faint yellow to brown xanchromatic granule; Feeble QI perfume (or spice), it is sweet to distinguish the flavor of.
Embodiment 2
Radix Ginseng Rubra 21.3g, Radix Angelicae Sinensis 32g, Herba Leonuri 42.7g, Radix Rehmanniae Preparata 32g, Rhizoma Cyperi (processed with vinegar) 10.7g, Carapax et Plastrum Testudinis(processed with vinegar) 5.3g, Cortex Lycii 5.3g, Rhizoma Corydalis (processed with vinegar) 3.2g, Semen Raphani (parched) 5.3g, Rhizoma Atractylodis Macrocephalae (parched with bran) 6.4, Colla Corii Asini 6.4g, Cortex Cinnamomi 3.2g, Radix Aucklandiae 3.2g, Radix Salviae Miltiorrhizae 21.3g, Radix Paeoniae Rubra 8.5g, Radix Glycyrrhizae 5.3g, salt Fructus Foeniculi (processed) 4.3g, Radix Dipsaci 10.7g, Pollen Typhae 5.3g, Rhizoma Chuanxiong 5.3g, Radix Achyranthis Bidentatae 5.3g, Cornu Cervi Pantotrichum 3.2g, Poria 64g, Embryo cervi 57.6g.Get Embryo cervi, afterbirth is cut, collect amniotic fluid and put in addition; Peeling off the crust of Embryo cervi puts in addition.Embryo cervi is cut open the belly, remove clean meconium, stripping and slicing, afterbirth is stripping and slicing also, puts altogether in the pot, decoct with water three times, 2 hours for the first time, second and third time each 1 hour, amount of water is respectively 10,8,6 times, and to meatization, bone shortcake, gradation filters while hot, merging filtrate.The coat stripping and slicing of Embryo cervi decocts with water three times, and 2 hours for the first time, second and third time was respectively 1 hour, amount of water is respectively 11,9,7 times, and gradation filters while hot, and filtrate and above-mentioned filtrate merge, and are concentrated into thick, add amniotic fluid, stir evenly, continue to be condensed into paste, standby; Radix Ginseng Rubra, Cornu Cervi Pantotrichum, Colla Corii Asini are ground into fine powder, sieve; Rhizoma Cyperi, the Radix Aucklandiae, Fructus Foeniculi, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Rhizoma Chuanxiong add 8 times of water extraction volatile oil, time is 5 hours, volatile oil is made beta-cyclo dextrin included compound, aqueous solution after the distillation in addition device is collected, and medicinal residues are with 70% alcohol reflux secondary, each 2 hours, alcohol adding amount is respectively 8,6 times, merge extractive liquid, filters filtrate for later use; Rhizoma Corydalis, Radix Salviae Miltiorrhizae adds 7 times of amount alcohol reflux 3 hours, and medicinal residues add 5 times of amount 70% alcohol reflux 2 hours, merge extractive liquid, again, filter, filtrate and aforementioned filtrate merge, and reclaim ethanol, be concentrated into paste, standby, 11 flavors such as medicinal residues and Herba Leonuri decoct with water secondary, 3 hours for the first time, 2 hours for the second time, amount of water is respectively 10,8 times, gradation filters, merging filtrate, add the aqueous solution after distilling, being concentrated into relative density is 1.10～1.14 (80 ℃ of surveys), puts coldly, adds ethanol and makes and contain the alcohol amount and reach 70%, left standstill 24 hours, filter, filtrate recycling ethanol is concentrated into paste, add above-mentioned alcohol-extracted extract, Embryo cervi extractum, Radix Ginseng Rubra, Cornu Cervi Pantotrichum, donkey-hide gelatin fine powder, the volatile oil beta-cyclodextrin inclusion complex, dextrin, the brown sugar fine powder, sodium carboxymethyl cellulose, make granule 1000g, packing, promptly.This product is faint yellow to brown xanchromatic granule; Feeble QI perfume (or spice), it is sweet to distinguish the flavor of.
Claims (1)
1, a kind of production technology of Embryo cervi granule Chinese medicine preparation may further comprise the steps:
Take by weighing Radix Ginseng Rubra 20-35 part respectively, Radix Angelicae Sinensis 30-50 part, Herba Leonuri 40-65 part, Radix Rehmanniae Preparata 30-50 part, Rhizoma Cyperi (processed with vinegar) 10-18 part, Carapax et Plastrum Testudinis(processed with vinegar) 5-8 part, Cortex Lycii 5-10 part, Rhizoma Corydalis (processed with vinegar) 3-6 part, Rhizoma Atractylodis Macrocephalae (parched with bran) 6-10 part, Colla Corii Asini 6-10 part, Radix Salviae Miltiorrhizae 20-35 part, Radix Paeoniae Rubra 8-15 part, Radix Dipsaci 10-18 part, Rhizoma Chuanxiong 5-10 part, Radix Achyranthis Bidentatae 5-10 part, Cornu Cervi Pantotrichum 3-6 part, Poria 60-100 part, Embryo cervi 50-100 part, Semen Raphani (parched) 5-10 part, Cortex Cinnamomi 3-6 part, Radix Aucklandiae 3-6 part, Radix Glycyrrhizae 5-10 part, salt Fructus Foeniculi (processed) 4-8 part, Pollen Typhae 5-10 part; Get Embryo cervi, afterbirth is cut, collect amniotic fluid and put in addition; Peeling off the crust of Embryo cervi puts in addition; Embryo cervi is cut open the belly, remove clean meconium, stripping and slicing, afterbirth is stripping and slicing also, puts altogether in the pot, decocts with water 1～3 time, and each 1-2 hour, amount of water was respectively 10-6 doubly, and to meatization, bone shortcake, gradation filters while hot, merging filtrate; The coat stripping and slicing of Embryo cervi decocts with water 1-3 time, and each 1-2 hour, amount of water was respectively 11-7 doubly, and filtrate merges with above-mentioned filtrate, is concentrated into thickly, and the adding amniotic fluid stirs evenly, and continues to be condensed into paste, and is standby; Radix Ginseng Rubra, Cornu Cervi Pantotrichum, Colla Corii Asini are ground into fine powder, sieve; Rhizoma Cyperi, the Radix Aucklandiae, Fructus Foeniculi, Radix Angelicae Sinensis, the Rhizoma Atractylodis Macrocephalae, Cortex Cinnamomi, Rhizoma Chuanxiong add 4-8 times of water extraction volatile oil, and volatile oil is made beta-cyclo dextrin included compound, and the aqueous solution after distillation device is in addition collected, medicinal residues are with the 60-85% alcohol reflux, alcohol adding amount is respectively 8-6 doubly, filters filtrate for later use; Rhizoma Corydalis, Radix Salviae Miltiorrhizae adds 4-8 and doubly measures alcohol reflux, medicinal residues add 2-5 again and doubly measure 70% alcohol reflux, filter, filtrate and aforementioned filtrate merge, and reclaim ethanol, be concentrated into paste, standby, medicinal residues and all the other 11 flavors decoct with water each 1-3 hour 2-3 time, amount of water is respectively 10-6 doubly, gradation filters, and merging filtrate adds the aqueous solution after distilling, being concentrated into relative density is 1.10～1.14,80 ℃ of detections are put coldly, add ethanol and make and contain the alcohol amount and reach 60-70%, leave standstill, filter, filtrate recycling ethanol is concentrated into paste, add above-mentioned alcohol-extracted extract, Embryo cervi extractum, Radix Ginseng Rubra, Cornu Cervi Pantotrichum, donkey-hide gelatin fine powder, the volatile oil beta-cyclodextrin inclusion complex, dextrin, the brown sugar fine powder, sodium carboxymethyl cellulose is made granule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100107166A CN1255154C (en) | 2004-03-03 | 2004-03-03 | Deer's fetus granular Chinese madicinal preparation and its production technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100107166A CN1255154C (en) | 2004-03-03 | 2004-03-03 | Deer's fetus granular Chinese madicinal preparation and its production technology |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1559495A CN1559495A (en) | 2005-01-05 |
| CN1255154C true CN1255154C (en) | 2006-05-10 |
Family
ID=34440010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100107166A Expired - Lifetime CN1255154C (en) | 2004-03-03 | 2004-03-03 | Deer's fetus granular Chinese madicinal preparation and its production technology |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1255154C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109172693A (en) * | 2018-11-14 | 2019-01-11 | 广西志诚孝善三商贸有限公司 | For improving palace cold and improving the gynecological gel of the uterus cold of insufficiency type |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101757599B (en) * | 2010-02-01 | 2011-04-13 | 刘同亭 | Medicinal granules comprising brown sugar, Colla corii Asini, Cornu cervi Pantotrichum, ginseng, clove, costus root, red jujube and tea |
| CN103468503B (en) * | 2013-09-06 | 2014-08-20 | 铁岭市西丰御林鹿业集团有限公司 | Fetus cervi healthcare wine |
| CN103610045B (en) * | 2013-11-21 | 2014-11-05 | 西丰鹿源生物医药科技研发中心 | Deer fetus granule and preparation method for same |
| CN104397703B (en) * | 2014-12-10 | 2017-03-15 | 无锡瑞年实业有限公司 | A kind of Chinese medicinal tablet of strengthen immunity |
| CN106692589A (en) * | 2017-01-19 | 2017-05-24 | 奉化市同发梅花鹿养殖专业合作社 | Deer foetus semifluid extract and preparation process thereof |
| CN107007793A (en) * | 2017-04-27 | 2017-08-04 | 山东省千佛山医院 | It is a kind of to treat Chinese medicine composition of dysmenorrhoea and preparation method thereof |
| CN108497379A (en) * | 2018-03-25 | 2018-09-07 | 吉林省金鹿药业有限公司 | Using the health food and preparation method of the anti-aging nti-freckle of sika deer deer tire |
| CN108676680A (en) * | 2018-07-27 | 2018-10-19 | 兴义市付氏养殖农民专业合作社 | A kind of SiKa Deer Fetus health liquor that breaking away from irregular menstruation and its processing method |
| CN110946939A (en) * | 2019-12-17 | 2020-04-03 | 抚州市东乡区志方梅花鹿养殖有限公司 | Deer fetus ointment and preparation method thereof |
-
2004
- 2004-03-03 CN CNB2004100107166A patent/CN1255154C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109172693A (en) * | 2018-11-14 | 2019-01-11 | 广西志诚孝善三商贸有限公司 | For improving palace cold and improving the gynecological gel of the uterus cold of insufficiency type |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1559495A (en) | 2005-01-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1255154C (en) | Deer's fetus granular Chinese madicinal preparation and its production technology | |
| CN104922543A (en) | Medicine composite for treating amenorrhea and preparation method thereof | |
| CN101507776B (en) | Traditional Chinese medicine preparation for treating kidney deficiency, waist and knees soreness and preparation method thereof | |
| CN1297291C (en) | Medicine for abstaining from drug addiction and its preparation | |
| CN104491695A (en) | Pharmaceutical composition for treating chloasma | |
| CN1726991A (en) | Medication of treating by dysenorrhea, irregular menses, weakness after childbirth for women, and preparation method | |
| CN1927331A (en) | Chinese medicine preparation for curing chronic heart failure | |
| CN101028325A (en) | Medicinal composition containing sailonggu, and its preparation and quality control | |
| CN1232279C (en) | Antilipemic Chinese medicine | |
| CN105944020B (en) | Traditional Chinese medicine for treating ovarian function decline | |
| CN104524247A (en) | Pharmaceutical composition for treating migraine and application thereof | |
| CN104436048A (en) | Use of traditional Chinese medicine preparation in preparation of medicine for treating qi stagnation and blood stasis type chloasma | |
| CN110237161B (en) | Medicine for treating menopausal syndrome and preparation method and application thereof | |
| CN1857605A (en) | Medicine for treating chronic alcoholic hepatopathy and its preparing method | |
| CN102895387A (en) | Kidney-yang-warming medicine composition, and preparation thereof and preparation method thereof | |
| CN112451608A (en) | Kidney-tonifying yang-warming collateral-dredging formula with bone and kidney simultaneous treatment effect | |
| CN110051812A (en) | A kind of strengthening vital QI to eliminate pathogenic factors Chinese medicine and preparation method thereof | |
| CN104208640A (en) | Traditional Chinese medicine composition for treating delayed menstrual cycle | |
| CN104888042A (en) | Chinese herbal preparation used for postpartum lochiorrhea and preparation method of Chinese herbal preparation | |
| CN1593493A (en) | Therapy assisting agent and its preparation | |
| CN112755137B (en) | Traditional Chinese medicine composition for treating mild and moderate knee osteoarthritis and application thereof | |
| CN116350731B (en) | Formula for clearing heat, removing dampness and relieving arthralgia as well as preparation and application thereof | |
| CN103142898B (en) | Preparation method of medicine used after esophageal achalasia operation | |
| CN1309412C (en) | Medicine composition for treating AIDS and preparing method thereof | |
| CN100349592C (en) | Chinese medicine composition for treating bone disease, its preparation and use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20060510 |