CN1704129A - 一种可吸收羟基磷灰石人工骨的制备工艺 - Google Patents
一种可吸收羟基磷灰石人工骨的制备工艺 Download PDFInfo
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- CN1704129A CN1704129A CN 200410044360 CN200410044360A CN1704129A CN 1704129 A CN1704129 A CN 1704129A CN 200410044360 CN200410044360 CN 200410044360 CN 200410044360 A CN200410044360 A CN 200410044360A CN 1704129 A CN1704129 A CN 1704129A
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- coral
- artificial bone
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- 210000000988 bone and bone Anatomy 0.000 title claims abstract description 61
- 229910052588 hydroxylapatite Inorganic materials 0.000 title claims abstract description 21
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title claims abstract description 21
- 238000002360 preparation method Methods 0.000 title claims description 5
- 238000000034 method Methods 0.000 title abstract description 5
- 230000002745 absorbent Effects 0.000 title abstract 2
- 239000002250 absorbent Substances 0.000 title abstract 2
- 235000014653 Carica parviflora Nutrition 0.000 claims abstract description 36
- 241000243321 Cnidaria Species 0.000 claims abstract description 33
- 238000006243 chemical reaction Methods 0.000 claims abstract description 24
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000001035 drying Methods 0.000 claims abstract description 7
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims abstract description 6
- 238000005530 etching Methods 0.000 claims abstract description 4
- 238000005406 washing Methods 0.000 claims abstract description 4
- 239000011148 porous material Substances 0.000 claims description 17
- 229910000394 calcium triphosphate Inorganic materials 0.000 claims description 9
- RFWLACFDYFIVMC-UHFFFAOYSA-D pentacalcium;[oxido(phosphonatooxy)phosphoryl] phosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O.[O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O RFWLACFDYFIVMC-UHFFFAOYSA-D 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 8
- 238000002791 soaking Methods 0.000 claims description 7
- 239000013505 freshwater Substances 0.000 claims description 3
- 239000005708 Sodium hypochlorite Substances 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- 230000005251 gamma ray Effects 0.000 claims description 2
- 229910017053 inorganic salt Inorganic materials 0.000 claims description 2
- 230000003287 optical effect Effects 0.000 claims description 2
- 238000004806 packaging method and process Methods 0.000 claims description 2
- 238000007789 sealing Methods 0.000 claims description 2
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims description 2
- 230000001954 sterilising effect Effects 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- LFVGISIMTYGQHF-UHFFFAOYSA-N ammonium dihydrogen phosphate Chemical compound [NH4+].OP(O)([O-])=O LFVGISIMTYGQHF-UHFFFAOYSA-N 0.000 claims 1
- 229910000387 ammonium dihydrogen phosphate Inorganic materials 0.000 claims 1
- 235000019837 monoammonium phosphate Nutrition 0.000 claims 1
- 238000000643 oven drying Methods 0.000 claims 1
- 239000013078 crystal Substances 0.000 abstract description 6
- 239000000463 material Substances 0.000 description 8
- 239000000243 solution Substances 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 4
- 241000242757 Anthozoa Species 0.000 description 3
- 230000007547 defect Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002054 transplantation Methods 0.000 description 3
- 230000000735 allogeneic effect Effects 0.000 description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 description 2
- 239000001506 calcium phosphate Substances 0.000 description 2
- 235000011010 calcium phosphates Nutrition 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 230000007721 medicinal effect Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000010306 acid treatment Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000007681 cardiovascular toxicity Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 238000002316 cosmetic surgery Methods 0.000 description 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical class [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 231100001083 no cytotoxicity Toxicity 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 210000002997 osteoclast Anatomy 0.000 description 1
- 210000001539 phagocyte Anatomy 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 238000005201 scrubbing Methods 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
Description
Claims (1)
- 一、一种可吸收羟基磷灰石人工骨的制备工艺,其特征在于用以下步骤制得:①天然珊瑚用淡水浸泡洗净(祛除珊瑚中的有机物)干燥,用次氯酸钠溶液漂洗后,再用蒸溜水反复冲洗,如此反复二次,烘干备用;②用稀盐酸对珊瑚孔道进行蚀刻使孔道表面粗糙,扩大其孔道径;③用饱和磷酸盐溶液浸泡珊瑚,并和浸泡液一起置于特制的化学容器(反应釜)内,在0.3-3Mpa的压力下,以140-180℃的温度与反应48-72小时,即制得所需要的生物活性羟基磷灰石人工骨,其反应生成80-90%的珊瑚羟基磷灰石{结晶状,其化学方程为:二、根据权利要求书一所述的人工骨的制备工艺,其特征在于所述的饱和磷酸盐溶液是磷酸二氢铵溶液。三、根据权利要求书一所述的人工骨的制备工艺,其特征在于对天然珊瑚进行置换反应前,对珊瑚进行的蚀刻是用0.001%的稀盐酸对珊瑚孔道进行处理,在光学显微镜下控制其孔道直径约200um。
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CNB2004100443608A CN100384488C (zh) | 2004-05-28 | 2004-05-28 | 一种可吸收羟基磷灰石人工骨的制备工艺 |
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CNB2004100443608A CN100384488C (zh) | 2004-05-28 | 2004-05-28 | 一种可吸收羟基磷灰石人工骨的制备工艺 |
Publications (2)
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CN1704129A true CN1704129A (zh) | 2005-12-07 |
CN100384488C CN100384488C (zh) | 2008-04-30 |
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CNB2004100443608A Expired - Fee Related CN100384488C (zh) | 2004-05-28 | 2004-05-28 | 一种可吸收羟基磷灰石人工骨的制备工艺 |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102274547A (zh) * | 2011-07-18 | 2011-12-14 | 湖南康胜生物材料科技有限公司 | 一种表面羟基磷灰石置换珊瑚人工骨的制备工艺 |
CN104147637A (zh) * | 2013-05-14 | 2014-11-19 | 中南大学 | 一种复合陶瓷骨支架表面微-纳米孔隙的构建方法 |
CN111465419A (zh) * | 2017-12-14 | 2020-07-28 | 盖斯特里希医药公司 | 骨替代材料 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6376573B1 (en) * | 1994-12-21 | 2002-04-23 | Interpore International | Porous biomaterials and methods for their manufacture |
CN1069614C (zh) * | 1998-05-16 | 2001-08-15 | 冯守华 | 天然珊瑚羟基磷灰石多孔生物材料的化学扩孔方法 |
CN1199035A (zh) * | 1998-05-16 | 1998-11-18 | 冯守华 | 从天然珊瑚制备羟基磷灰石多孔生物材料的技术 |
CN1128097C (zh) * | 1998-06-19 | 2003-11-19 | 中山医科大学中山眼科中心 | 将珊瑚转变为羟基磷灰石“人工骨”的制备工艺 |
AUPR152100A0 (en) * | 2000-11-16 | 2000-12-14 | University Of Technology, Sydney | Method for treating coral |
CN1235645C (zh) * | 2003-06-18 | 2006-01-11 | 中山大学 | 珊瑚羟基磷灰石人工骨的合成方法 |
-
2004
- 2004-05-28 CN CNB2004100443608A patent/CN100384488C/zh not_active Expired - Fee Related
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102274547A (zh) * | 2011-07-18 | 2011-12-14 | 湖南康胜生物材料科技有限公司 | 一种表面羟基磷灰石置换珊瑚人工骨的制备工艺 |
CN104147637A (zh) * | 2013-05-14 | 2014-11-19 | 中南大学 | 一种复合陶瓷骨支架表面微-纳米孔隙的构建方法 |
CN104147637B (zh) * | 2013-05-14 | 2016-01-06 | 中南大学 | 一种复合陶瓷骨支架表面微-纳米孔隙的构建方法 |
CN111465419A (zh) * | 2017-12-14 | 2020-07-28 | 盖斯特里希医药公司 | 骨替代材料 |
CN111465419B (zh) * | 2017-12-14 | 2021-06-25 | 盖斯特里希医药公司 | 骨替代材料 |
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C41 | Transfer of patent application or patent right or utility model | ||
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Effective date of registration: 20051028 Address after: No. 3, Datong Road, Datong, Hainan, Haikou Applicant after: Liang Hui Co-applicant after: Meng Zhibin Co-applicant after: Fu Kun Address before: Hainan province Haikou city haidiandao people's Avenue Nanyuan building B, 11 floor, room A Applicant before: Zhang Donghai Co-applicant before: Meng Zhibin Co-applicant before: Zhang Hongzu |
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C14 | Grant of patent or utility model | ||
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EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Hunan Kangsheng Biological Material Technology Co.,Ltd. Assignor: Liang Hui|Meng Zhibin|Fu Kun Contract record no.: 2011430000011 Denomination of invention: Preparation technique of absorbent hydroxyapatite artificial bone Granted publication date: 20080430 License type: Exclusive License Open date: 20051207 Record date: 20110311 |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20080430 Termination date: 20150528 |
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