CN1698814B - 一种治疗急慢性咽炎及喉炎症的口含片的制备方法 - Google Patents
一种治疗急慢性咽炎及喉炎症的口含片的制备方法 Download PDFInfo
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Abstract
Description
平皿编号 | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
样品稀释度 | 1/10 | 1/20 | 1/40 | 1/80 | 1/160 | 1/320 | 1/640 | 1/1280 | 1/2560 | 1/5120 |
生药浓度(m克/ml) | 280.0 | 140.0 | 70.0 | 35.0 | 17.5 | 8.8 | 4.4 | 2.2 | 1.1 | 0.6 |
金黄色葡萄球菌 | - | - | - | - | - | - | - | + | + | + |
白色葡萄球菌 | - | - | - | - | + | + | + | + | + | + |
肺炎克雷伯氏菌 | - | - | - | + | + | + | + | + | + | + |
甲型溶血链球菌 | - | - | - | - | + | + | + | + | + | + |
卡他奈瑟氏菌 | - | - | - | - | + | + | + | + | + | + |
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 200510075041 CN1698814B (zh) | 2004-08-04 | 2005-06-08 | 一种治疗急慢性咽炎及喉炎症的口含片的制备方法 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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CN200410070157.8 | 2004-08-04 | ||
CN 200410070157 CN1602946A (zh) | 2004-08-04 | 2004-08-04 | 一种治疗急慢性咽炎及口腔炎症的口含片及其制备方法 |
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刘绍贵、陈娟.正交试验法优选铁笛含片(玄麦咽康含片)的水煮提取工艺.中国药业8 12.1999,8(12),17. |
刘绍贵、陈娟.正交试验法优选铁笛含片(玄麦咽康含片)的水煮提取工艺.中国药业8 12.1999,8(12),17. * |
药典委员会.中华人民共和国卫生部药品标准中药成方制剂 第一册.1989,130. * |
药典委员会.中华人民共和国卫生部药品标准中药成方制剂第一册.1989,130. |
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