CN1692124B - 与p53结合的T细胞受体分子以及其用途 - Google Patents

与p53结合的T细胞受体分子以及其用途 Download PDF

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Publication number
CN1692124B
CN1692124B CN028153030A CN02815303A CN1692124B CN 1692124 B CN1692124 B CN 1692124B CN 028153030 A CN028153030 A CN 028153030A CN 02815303 A CN02815303 A CN 02815303A CN 1692124 B CN1692124 B CN 1692124B
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Prior art keywords
tcr
chain
amino acid
acid sequence
seq
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Expired - Lifetime
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CN028153030A
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Chinese (zh)
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CN1692124A (zh
Inventor
L·A·舍曼
K·F·卡德
J·A·韦丹兹
H·C·王
E·L·汤姆森
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Scripps Research Institute
Altor Bioscience LLC
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Scripps Research Institute
Altor Bioscience LLC
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Publication of CN1692124A publication Critical patent/CN1692124A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN028153030A 2001-06-05 2002-06-05 与p53结合的T细胞受体分子以及其用途 Expired - Lifetime CN1692124B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29632401P 2001-06-05 2001-06-05
US60/296,324 2001-06-05
PCT/US2002/017785 WO2004018619A2 (en) 2001-06-05 2002-06-05 P53 binding t cell receptor molecules and uses thereof

Publications (2)

Publication Number Publication Date
CN1692124A CN1692124A (zh) 2005-11-02
CN1692124B true CN1692124B (zh) 2012-05-30

Family

ID=31946570

Family Applications (1)

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CN028153030A Expired - Lifetime CN1692124B (zh) 2001-06-05 2002-06-05 与p53结合的T细胞受体分子以及其用途

Country Status (11)

Country Link
US (1) US7456263B2 (https=)
EP (2) EP1546188B1 (https=)
JP (1) JP4447456B2 (https=)
CN (1) CN1692124B (https=)
AT (1) ATE405582T1 (https=)
AU (1) AU2002316190B8 (https=)
CA (1) CA2487779C (https=)
DE (1) DE60228504D1 (https=)
DK (1) DK1546188T3 (https=)
ES (1) ES2307770T3 (https=)
WO (1) WO2004018619A2 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7524601A (en) * 2000-06-05 2001-12-17 Sunol Molecular Corp T cell receptor fusions and conjugates and methods of use thereof
KR101131297B1 (ko) * 2003-11-10 2012-03-30 알토 바이오사이언스 코포레이션 가용성 티씨알 분자 및 이용 방법
US7994298B2 (en) 2004-09-24 2011-08-09 Trustees Of Dartmouth College Chimeric NK receptor and methods for treating cancer
EP2486049A1 (en) 2009-10-06 2012-08-15 The Board Of Trustees Of The UniversityOf Illinois Human single-chain t cell receptors
WO2011059836A2 (en) 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
US12492376B2 (en) 2009-10-29 2025-12-09 The Trustees Of Dartmouth College T-cell receptor-deficient T cell compositions
WO2013033626A2 (en) 2011-08-31 2013-03-07 Trustees Of Dartmouth College Nkp30 receptor targeted therapeutics
WO2013169691A1 (en) 2012-05-07 2013-11-14 Trustees Of Dartmouth College Anti-b7-h6 antibody, fusion proteins, and methods of using the same
UA114108C2 (uk) 2012-07-10 2017-04-25 Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання
WO2019067243A1 (en) * 2017-09-29 2019-04-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services T CELL RECEPTORS RECOGNIZING P53 MUTE
WO2019069125A1 (en) 2017-10-06 2019-04-11 Oslo Universitetssykehus Hf CHIMERIC ANTIGEN RECEPTORS
CN108060135A (zh) * 2017-12-26 2018-05-22 东莞赛尔生物科技有限公司 一种高效表达p53抑癌蛋白的t细胞、制备方法及应用
CA3095757A1 (en) 2018-04-06 2019-10-10 The Regents Of The University Of California Methods of treating glioblastomas
CA3096202A1 (en) 2018-04-06 2019-10-10 The Regents Of The University Of California Methods of treating egfrviii expressing glioblastomas

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4867973A (en) 1984-08-31 1989-09-19 Cytogen Corporation Antibody-therapeutic agent conjugates
US5057313A (en) 1986-02-25 1991-10-15 The Center For Molecular Medicine And Immunology Diagnostic and therapeutic antibody conjugates
WO1988007553A1 (fr) 1987-03-26 1988-10-06 Teijin Limited Procede de preparation d'un complexe d'anticorps
CA2076347C (en) 1990-02-20 1996-11-26 Ravinder K. Gupta Improved antibody-enzyme direct conjugates and method of making same
GB9200417D0 (en) 1992-01-09 1992-02-26 Bagshawe Kenneth D Cytotoxic drug therapy
US6399368B1 (en) 1992-01-17 2002-06-04 Board Of Regents, The University Of Texas System Secretion of T cell receptor fragments from recombinant Escherichia coli cells
ES2139012T3 (es) * 1992-05-26 2000-02-01 Univ Leiden Peptidos de la proteina p53 humana destinados para ser utilizados en composiciones que inducen una reaccion en los linfocitos t humanos, y linfocitos t citotoxicos especificos de la proteina p53 humana.
WO1994012520A1 (en) 1992-11-20 1994-06-09 Enzon, Inc. Linker for linked fusion polypeptides
WO1996004314A1 (en) 1994-07-29 1996-02-15 Dade International, Inc. Mhc complexes and uses thereof
WO1996013593A2 (en) 1994-10-26 1996-05-09 Procept, Inc. Soluble single chain t cell receptors
WO1996018409A1 (en) * 1994-12-14 1996-06-20 The Scripps Research Institute In vivo activation of tumor-specific cytotoxic t cells
US5830755A (en) 1995-03-27 1998-11-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services T-cell receptors and their use in therapeutic and diagnostic methods
US5869270A (en) 1996-01-31 1999-02-09 Sunol Molecular Corporation Single chain MHC complexes and uses thereof
CA2246333A1 (en) 1996-03-05 1997-09-12 The Scripps Research Institute Recombinant constructs encoding t cell receptors specific for human hla-restricted tumor antigens
US6127524A (en) 1996-10-18 2000-10-03 Dade Behring Inc. Binding molecules and computer-based methods of increasing the binding affinity thereof
WO1998039482A1 (en) 1997-03-07 1998-09-11 Sunol Molecular Corporation Fusion proteins comprising bacteriophage coat protein and a single-chain t cell receptor
ATE533784T1 (de) 1997-10-02 2011-12-15 Altor Bioscience Corp Lösliche, einzelkettige proteine des t- zellrezeptors
DE69936927T2 (de) 1998-10-21 2008-05-15 Altor Bioscience Corp., Miramar Polyspezifische bindemoleküle und deren verwendung
EP1287363A2 (en) 2000-05-25 2003-03-05 Sunol Molecular Corporation Modulation of t-cell receptor interactions
AU7524601A (en) 2000-06-05 2001-12-17 Sunol Molecular Corp T cell receptor fusions and conjugates and methods of use thereof
DE10109855A1 (de) 2001-03-01 2002-09-12 Stanislawski Thomas Polypeptide eines p53-Protein-spezifischen murinen alpha/beta T-Zell Rezeptors, diese kodierende Nukleinsäuren und deren Verwendung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
THEOBALD M等.Targeting p53 as a general tumor antigen.PNAS92.1995,9211993-11997. *

Also Published As

Publication number Publication date
JP4447456B2 (ja) 2010-04-07
WO2004018619A3 (en) 2005-05-06
ES2307770T3 (es) 2008-12-01
ATE405582T1 (de) 2008-09-15
EP1546188A2 (en) 2005-06-29
DE60228504D1 (de) 2008-10-02
CA2487779A1 (en) 2004-03-04
WO2004018619A2 (en) 2004-03-04
CA2487779C (en) 2012-10-02
CN1692124A (zh) 2005-11-02
EP1546188B1 (en) 2008-08-20
AU2002316190B2 (en) 2009-01-22
EP2009019A1 (en) 2008-12-31
EP1546188A4 (en) 2005-12-21
US20080269113A1 (en) 2008-10-30
DK1546188T3 (da) 2008-10-27
JP2005525128A (ja) 2005-08-25
AU2002316190A1 (en) 2004-03-17
AU2002316190B8 (en) 2009-01-29
US7456263B2 (en) 2008-11-25
AU2002316190A8 (en) 2004-04-08

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