DK1546188T3 - P53-bindende T-cellereceptormolekyler og anvendelser deraf - Google Patents
P53-bindende T-cellereceptormolekyler og anvendelser derafInfo
- Publication number
- DK1546188T3 DK1546188T3 DK02746470T DK02746470T DK1546188T3 DK 1546188 T3 DK1546188 T3 DK 1546188T3 DK 02746470 T DK02746470 T DK 02746470T DK 02746470 T DK02746470 T DK 02746470T DK 1546188 T3 DK1546188 T3 DK 1546188T3
- Authority
- DK
- Denmark
- Prior art keywords
- molecules
- protein
- tcr
- cell receptor
- binding
- Prior art date
Links
- 108091008874 T cell receptors Proteins 0.000 title abstract 5
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 title abstract 5
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29632401P | 2001-06-05 | 2001-06-05 | |
| PCT/US2002/017785 WO2004018619A2 (en) | 2001-06-05 | 2002-06-05 | P53 binding t cell receptor molecules and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1546188T3 true DK1546188T3 (da) | 2008-10-27 |
Family
ID=31946570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02746470T DK1546188T3 (da) | 2001-06-05 | 2002-06-05 | P53-bindende T-cellereceptormolekyler og anvendelser deraf |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7456263B2 (https=) |
| EP (2) | EP1546188B1 (https=) |
| JP (1) | JP4447456B2 (https=) |
| CN (1) | CN1692124B (https=) |
| AT (1) | ATE405582T1 (https=) |
| AU (1) | AU2002316190B8 (https=) |
| CA (1) | CA2487779C (https=) |
| DE (1) | DE60228504D1 (https=) |
| DK (1) | DK1546188T3 (https=) |
| ES (1) | ES2307770T3 (https=) |
| WO (1) | WO2004018619A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7524601A (en) * | 2000-06-05 | 2001-12-17 | Sunol Molecular Corp | T cell receptor fusions and conjugates and methods of use thereof |
| KR101131297B1 (ko) * | 2003-11-10 | 2012-03-30 | 알토 바이오사이언스 코포레이션 | 가용성 티씨알 분자 및 이용 방법 |
| US7994298B2 (en) | 2004-09-24 | 2011-08-09 | Trustees Of Dartmouth College | Chimeric NK receptor and methods for treating cancer |
| EP2486049A1 (en) | 2009-10-06 | 2012-08-15 | The Board Of Trustees Of The UniversityOf Illinois | Human single-chain t cell receptors |
| WO2011059836A2 (en) | 2009-10-29 | 2011-05-19 | Trustees Of Dartmouth College | T cell receptor-deficient t cell compositions |
| US9273283B2 (en) | 2009-10-29 | 2016-03-01 | The Trustees Of Dartmouth College | Method of producing T cell receptor-deficient T cells expressing a chimeric receptor |
| US12492376B2 (en) | 2009-10-29 | 2025-12-09 | The Trustees Of Dartmouth College | T-cell receptor-deficient T cell compositions |
| WO2013033626A2 (en) | 2011-08-31 | 2013-03-07 | Trustees Of Dartmouth College | Nkp30 receptor targeted therapeutics |
| WO2013169691A1 (en) | 2012-05-07 | 2013-11-14 | Trustees Of Dartmouth College | Anti-b7-h6 antibody, fusion proteins, and methods of using the same |
| UA114108C2 (uk) | 2012-07-10 | 2017-04-25 | Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем | Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання |
| WO2019067243A1 (en) * | 2017-09-29 | 2019-04-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | T CELL RECEPTORS RECOGNIZING P53 MUTE |
| WO2019069125A1 (en) | 2017-10-06 | 2019-04-11 | Oslo Universitetssykehus Hf | CHIMERIC ANTIGEN RECEPTORS |
| CN108060135A (zh) * | 2017-12-26 | 2018-05-22 | 东莞赛尔生物科技有限公司 | 一种高效表达p53抑癌蛋白的t细胞、制备方法及应用 |
| CA3095757A1 (en) | 2018-04-06 | 2019-10-10 | The Regents Of The University Of California | Methods of treating glioblastomas |
| CA3096202A1 (en) | 2018-04-06 | 2019-10-10 | The Regents Of The University Of California | Methods of treating egfrviii expressing glioblastomas |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4867973A (en) | 1984-08-31 | 1989-09-19 | Cytogen Corporation | Antibody-therapeutic agent conjugates |
| US5057313A (en) | 1986-02-25 | 1991-10-15 | The Center For Molecular Medicine And Immunology | Diagnostic and therapeutic antibody conjugates |
| WO1988007553A1 (fr) | 1987-03-26 | 1988-10-06 | Teijin Limited | Procede de preparation d'un complexe d'anticorps |
| CA2076347C (en) | 1990-02-20 | 1996-11-26 | Ravinder K. Gupta | Improved antibody-enzyme direct conjugates and method of making same |
| GB9200417D0 (en) | 1992-01-09 | 1992-02-26 | Bagshawe Kenneth D | Cytotoxic drug therapy |
| US6399368B1 (en) | 1992-01-17 | 2002-06-04 | Board Of Regents, The University Of Texas System | Secretion of T cell receptor fragments from recombinant Escherichia coli cells |
| ES2139012T3 (es) * | 1992-05-26 | 2000-02-01 | Univ Leiden | Peptidos de la proteina p53 humana destinados para ser utilizados en composiciones que inducen una reaccion en los linfocitos t humanos, y linfocitos t citotoxicos especificos de la proteina p53 humana. |
| WO1994012520A1 (en) | 1992-11-20 | 1994-06-09 | Enzon, Inc. | Linker for linked fusion polypeptides |
| WO1996004314A1 (en) | 1994-07-29 | 1996-02-15 | Dade International, Inc. | Mhc complexes and uses thereof |
| WO1996013593A2 (en) | 1994-10-26 | 1996-05-09 | Procept, Inc. | Soluble single chain t cell receptors |
| WO1996018409A1 (en) * | 1994-12-14 | 1996-06-20 | The Scripps Research Institute | In vivo activation of tumor-specific cytotoxic t cells |
| US5830755A (en) | 1995-03-27 | 1998-11-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | T-cell receptors and their use in therapeutic and diagnostic methods |
| US5869270A (en) | 1996-01-31 | 1999-02-09 | Sunol Molecular Corporation | Single chain MHC complexes and uses thereof |
| CA2246333A1 (en) | 1996-03-05 | 1997-09-12 | The Scripps Research Institute | Recombinant constructs encoding t cell receptors specific for human hla-restricted tumor antigens |
| US6127524A (en) | 1996-10-18 | 2000-10-03 | Dade Behring Inc. | Binding molecules and computer-based methods of increasing the binding affinity thereof |
| WO1998039482A1 (en) | 1997-03-07 | 1998-09-11 | Sunol Molecular Corporation | Fusion proteins comprising bacteriophage coat protein and a single-chain t cell receptor |
| ATE533784T1 (de) | 1997-10-02 | 2011-12-15 | Altor Bioscience Corp | Lösliche, einzelkettige proteine des t- zellrezeptors |
| DE69936927T2 (de) | 1998-10-21 | 2008-05-15 | Altor Bioscience Corp., Miramar | Polyspezifische bindemoleküle und deren verwendung |
| EP1287363A2 (en) | 2000-05-25 | 2003-03-05 | Sunol Molecular Corporation | Modulation of t-cell receptor interactions |
| AU7524601A (en) | 2000-06-05 | 2001-12-17 | Sunol Molecular Corp | T cell receptor fusions and conjugates and methods of use thereof |
| DE10109855A1 (de) | 2001-03-01 | 2002-09-12 | Stanislawski Thomas | Polypeptide eines p53-Protein-spezifischen murinen alpha/beta T-Zell Rezeptors, diese kodierende Nukleinsäuren und deren Verwendung |
-
2002
- 2002-06-05 CA CA2487779A patent/CA2487779C/en not_active Expired - Lifetime
- 2002-06-05 US US10/163,084 patent/US7456263B2/en not_active Expired - Lifetime
- 2002-06-05 ES ES02746470T patent/ES2307770T3/es not_active Expired - Lifetime
- 2002-06-05 CN CN028153030A patent/CN1692124B/zh not_active Expired - Lifetime
- 2002-06-05 DK DK02746470T patent/DK1546188T3/da active
- 2002-06-05 EP EP02746470A patent/EP1546188B1/en not_active Expired - Lifetime
- 2002-06-05 WO PCT/US2002/017785 patent/WO2004018619A2/en not_active Ceased
- 2002-06-05 AT AT02746470T patent/ATE405582T1/de active
- 2002-06-05 AU AU2002316190A patent/AU2002316190B8/en not_active Expired
- 2002-06-05 EP EP08012635A patent/EP2009019A1/en not_active Withdrawn
- 2002-06-05 JP JP2004530731A patent/JP4447456B2/ja not_active Expired - Lifetime
- 2002-06-05 DE DE60228504T patent/DE60228504D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4447456B2 (ja) | 2010-04-07 |
| WO2004018619A3 (en) | 2005-05-06 |
| ES2307770T3 (es) | 2008-12-01 |
| ATE405582T1 (de) | 2008-09-15 |
| EP1546188A2 (en) | 2005-06-29 |
| DE60228504D1 (de) | 2008-10-02 |
| CA2487779A1 (en) | 2004-03-04 |
| WO2004018619A2 (en) | 2004-03-04 |
| CA2487779C (en) | 2012-10-02 |
| CN1692124A (zh) | 2005-11-02 |
| EP1546188B1 (en) | 2008-08-20 |
| AU2002316190B2 (en) | 2009-01-22 |
| EP2009019A1 (en) | 2008-12-31 |
| EP1546188A4 (en) | 2005-12-21 |
| US20080269113A1 (en) | 2008-10-30 |
| JP2005525128A (ja) | 2005-08-25 |
| CN1692124B (zh) | 2012-05-30 |
| AU2002316190A1 (en) | 2004-03-17 |
| AU2002316190B8 (en) | 2009-01-29 |
| US7456263B2 (en) | 2008-11-25 |
| AU2002316190A8 (en) | 2004-04-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1546188T3 (da) | P53-bindende T-cellereceptormolekyler og anvendelser deraf | |
| NO20053999D0 (no) | Survivin-avledede peptider og bruken av dem | |
| DK1124568T3 (da) | Polyspecifikke bindingsmolekyler og anvendelser deraf | |
| DE69730693D1 (de) | Mhc-komplexe und ihre verwendungen | |
| CY1109649T1 (el) | Αντιγονα και συνθεσεις απο neisseria | |
| DK0643726T3 (da) | Peptider af humant p53-protein til anvendelse i sammensætninger, som inducerer humant T-celle-respons, og humane p53-protei | |
| DK1187591T3 (da) | IBD-associerede mikrobielle antigener og fremgangsmåder til at anvende samme | |
| ATE533784T1 (de) | Lösliche, einzelkettige proteine des t- zellrezeptors | |
| CY1107881T1 (el) | Τροποποιημενα πεπτιδια ως θεραπευτικοι παραγοντες | |
| CY1110848T1 (el) | Αντισωμα αντι ανθρωπου νοgo α kai h φαρμακευτικη του χρηση | |
| HUP0401591A2 (hu) | Új receptor-nukleinsavak és- polipeptidek | |
| DE69940775D1 (de) | Peptidzusammensetzung als immunogen zur allergiebehandlung. | |
| ATE368688T1 (de) | Peptide, deren herstellung und verwendung zur bindung von immunglobulinen | |
| HUP0301812A2 (hu) | Átvizsgálási (screening) eljárás | |
| DE69931482D1 (de) | Isolierte peptide die aminosäuresequenzen von ny-eso-1 entsprechen und an mhc-klasse i und mhc klasse ii moleküle binden, und deren verwendungen | |
| EP1243923A4 (en) | METHOD FOR FINDING A CURE FOR CANCER WITH THE INTERACTION OF P53 AND MORTALIN INTERACTIONS | |
| RU2005106841A (ru) | Эпитопы т-клеток в эритропоэтине | |
| WO2001029220A3 (en) | Mage-a12 antigenic peptides and uses thereof | |
| RU2005108044A (ru) | Эпитопы т-клеток в стафилококковом энтеротоксине в | |
| ATE336579T1 (de) | Isolierte mhc-klasse ii-bindende peptide, und deren verwendung | |
| DK1436320T3 (da) | T-celle-epitoper af cyn D 1-allergenet fra bermudagræspollen | |
| HUP0301111A2 (hu) | Potenciálisan immundomináns acetilkolin-receptor oligopeptideket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| DE60308176D1 (de) | Vorrichtung von peptid- oder proteindarstellung, verfahren zu deren herstellung und deren verwendung |