ATE405582T1 - P53 bindende t-zellrezeptormoleküle und deren verwendungen - Google Patents

P53 bindende t-zellrezeptormoleküle und deren verwendungen

Info

Publication number
ATE405582T1
ATE405582T1 AT02746470T AT02746470T ATE405582T1 AT E405582 T1 ATE405582 T1 AT E405582T1 AT 02746470 T AT02746470 T AT 02746470T AT 02746470 T AT02746470 T AT 02746470T AT E405582 T1 ATE405582 T1 AT E405582T1
Authority
AT
Austria
Prior art keywords
molecules
protein
tcr
cell receptor
binding
Prior art date
Application number
AT02746470T
Other languages
English (en)
Inventor
Linda Sherman
Kimberlyn Card
Jon Weidanz
Hing Wong
Elizabeth Thomson
Original Assignee
Altor Bioscience Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altor Bioscience Corp filed Critical Altor Bioscience Corp
Application granted granted Critical
Publication of ATE405582T1 publication Critical patent/ATE405582T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT02746470T 2001-06-05 2002-06-05 P53 bindende t-zellrezeptormoleküle und deren verwendungen ATE405582T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US29632401P 2001-06-05 2001-06-05

Publications (1)

Publication Number Publication Date
ATE405582T1 true ATE405582T1 (de) 2008-09-15

Family

ID=31946570

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02746470T ATE405582T1 (de) 2001-06-05 2002-06-05 P53 bindende t-zellrezeptormoleküle und deren verwendungen

Country Status (11)

Country Link
US (1) US7456263B2 (de)
EP (2) EP2009019A1 (de)
JP (1) JP4447456B2 (de)
CN (1) CN1692124B (de)
AT (1) ATE405582T1 (de)
AU (1) AU2002316190B8 (de)
CA (1) CA2487779C (de)
DE (1) DE60228504D1 (de)
DK (1) DK1546188T3 (de)
ES (1) ES2307770T3 (de)
WO (1) WO2004018619A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1289564B1 (de) * 2000-06-05 2018-07-18 Altor BioScience Corporation T-zell-rezeptor fusionen und konjugate und verfahren zu deren verwendung
EP1691661B1 (de) * 2003-11-10 2014-01-08 Altor BioScience Corporation Lösliche tcr-moleküle und anwendungsverfahren
WO2006036445A2 (en) 2004-09-24 2006-04-06 Trustees Of Dartmouth College Chimeric nk receptor and methods for treating cancer
US10464987B2 (en) 2009-10-06 2019-11-05 Abbvie Inc. Human single-chain T cell receptors
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
WO2011059836A2 (en) 2009-10-29 2011-05-19 Trustees Of Dartmouth College T cell receptor-deficient t cell compositions
WO2013033626A2 (en) 2011-08-31 2013-03-07 Trustees Of Dartmouth College Nkp30 receptor targeted therapeutics
CN110511278A (zh) 2012-05-07 2019-11-29 达特茅斯大学理事会 抗b7-h6抗体、融合蛋白及其使用方法
UA114108C2 (uk) 2012-07-10 2017-04-25 Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання
SG11202002636PA (en) * 2017-09-29 2020-04-29 The United States Of America As Represented By The Secretary T cell receptors recognizing mutated p53
WO2019069125A1 (en) 2017-10-06 2019-04-11 Oslo Universitetssykehus Hf CHIMERIC ANTIGEN RECEPTORS
CN108060135A (zh) * 2017-12-26 2018-05-22 东莞赛尔生物科技有限公司 一种高效表达p53抑癌蛋白的t细胞、制备方法及应用

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US4867973A (en) * 1984-08-31 1989-09-19 Cytogen Corporation Antibody-therapeutic agent conjugates
US5057313A (en) * 1986-02-25 1991-10-15 The Center For Molecular Medicine And Immunology Diagnostic and therapeutic antibody conjugates
WO1988007553A1 (en) * 1987-03-26 1988-10-06 Teijin Limited Process for preparing antibody complex
AU656518B2 (en) * 1990-02-20 1995-02-09 Coulter Corporation Improved antibody-enzyme direct conjugates and method of making same
GB9200417D0 (en) * 1992-01-09 1992-02-26 Bagshawe Kenneth D Cytotoxic drug therapy
US6399368B1 (en) * 1992-01-17 2002-06-04 Board Of Regents, The University Of Texas System Secretion of T cell receptor fragments from recombinant Escherichia coli cells
DE69326064T2 (de) * 1992-05-26 2000-05-25 Rijksuniversiteit Te Leiden Le Peptide des menschlichen Proteins P53 zum Gebrauch in menschlichen-zytotoxischen-T-Zell-Antwort-induzierenden Kompositionen sowie menschliche P53-Protein-spezifische T-Lymphocyten
AU5670194A (en) * 1992-11-20 1994-06-22 Enzon, Inc. Linker for linked fusion polypeptides
JPH10503379A (ja) 1994-07-29 1998-03-31 デイド・インターナショナル・インコーポレーテッド Ｍｈｃ複合体およびその用途
WO1996013593A2 (en) 1994-10-26 1996-05-09 Procept, Inc. Soluble single chain t cell receptors
JPH10510988A (ja) * 1994-12-14 1998-10-27 ザ スクリップス リサーチ インスティテュート 腫瘍−特異的細胞毒性ｔ細胞のインビボ活性化
US5830755A (en) * 1995-03-27 1998-11-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services T-cell receptors and their use in therapeutic and diagnostic methods
US5869270A (en) 1996-01-31 1999-02-09 Sunol Molecular Corporation Single chain MHC complexes and uses thereof
AU728794B2 (en) 1996-03-05 2001-01-18 Scripps Research Institute, The Recombinant constructs encoding T cell receptors specific for human HLA-restricted tumor antigens
US6127524A (en) 1996-10-18 2000-10-03 Dade Behring Inc. Binding molecules and computer-based methods of increasing the binding affinity thereof
AU6685698A (en) 1997-03-07 1998-09-22 Sunol Molecular Corporation Fusion proteins comprising bacteriophage coat protein and a single-chain t cell receptor
JP2001519143A (ja) 1997-10-02 2001-10-23 スノル・モレキュラー・コーポレーション 可溶性の一本鎖ｔ細胞レセプタータンパク質
ATE370967T1 (de) 1998-10-21 2007-09-15 Altor Bioscience Corp Polyspezifische bindemoleküle und deren verwendung
EP1287363A2 (de) 2000-05-25 2003-03-05 Sunol Molecular Corporation Modulation von wechselwirkungen in t-zellrezeptoren
EP1289564B1 (de) 2000-06-05 2018-07-18 Altor BioScience Corporation T-zell-rezeptor fusionen und konjugate und verfahren zu deren verwendung
DE10109855A1 (de) * 2001-03-01 2002-09-12 Stanislawski Thomas Polypeptide eines p53-Protein-spezifischen murinen alpha/beta T-Zell Rezeptors, diese kodierende Nukleinsäuren und deren Verwendung

Also Published As

Publication number Publication date
AU2002316190B2 (en) 2009-01-22
EP1546188A2 (de) 2005-06-29
EP1546188B1 (de) 2008-08-20
AU2002316190A1 (en) 2004-03-17
CA2487779A1 (en) 2004-03-04
EP1546188A4 (de) 2005-12-21
CN1692124B (zh) 2012-05-30
WO2004018619A2 (en) 2004-03-04
AU2002316190B8 (en) 2009-01-29
US7456263B2 (en) 2008-11-25
DK1546188T3 (da) 2008-10-27
AU2002316190A8 (en) 2004-04-08
CN1692124A (zh) 2005-11-02
CA2487779C (en) 2012-10-02
DE60228504D1 (de) 2008-10-02
WO2004018619A3 (en) 2005-05-06
EP2009019A1 (de) 2008-12-31
US20080269113A1 (en) 2008-10-30
JP4447456B2 (ja) 2010-04-07
JP2005525128A (ja) 2005-08-25
ES2307770T3 (es) 2008-12-01

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