DK1546188T3 - P53-bindende T-cellereceptormolekyler og anvendelser deraf - Google Patents

P53-bindende T-cellereceptormolekyler og anvendelser deraf

Info

Publication number
DK1546188T3
DK1546188T3 DK02746470T DK02746470T DK1546188T3 DK 1546188 T3 DK1546188 T3 DK 1546188T3 DK 02746470 T DK02746470 T DK 02746470T DK 02746470 T DK02746470 T DK 02746470T DK 1546188 T3 DK1546188 T3 DK 1546188T3
Authority
DK
Denmark
Prior art keywords
molecules
protein
tcr
cell receptor
binding
Prior art date
Application number
DK02746470T
Other languages
Danish (da)
English (en)
Inventor
Jon A Weidanz
Elizabeth L Thomson
Linda A Sherman
Kimberlyn F Card
Hing C Wong
Original Assignee
Altor Bioscience Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Altor Bioscience Corp filed Critical Altor Bioscience Corp
Application granted granted Critical
Publication of DK1546188T3 publication Critical patent/DK1546188T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK02746470T 2001-06-05 2002-06-05 P53-bindende T-cellereceptormolekyler og anvendelser deraf DK1546188T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29632401P 2001-06-05 2001-06-05
PCT/US2002/017785 WO2004018619A2 (en) 2001-06-05 2002-06-05 P53 binding t cell receptor molecules and uses thereof

Publications (1)

Publication Number Publication Date
DK1546188T3 true DK1546188T3 (da) 2008-10-27

Family

ID=31946570

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02746470T DK1546188T3 (da) 2001-06-05 2002-06-05 P53-bindende T-cellereceptormolekyler og anvendelser deraf

Country Status (11)

Country Link
US (1) US7456263B2 (de)
EP (2) EP1546188B1 (de)
JP (1) JP4447456B2 (de)
CN (1) CN1692124B (de)
AT (1) ATE405582T1 (de)
AU (1) AU2002316190B8 (de)
CA (1) CA2487779C (de)
DE (1) DE60228504D1 (de)
DK (1) DK1546188T3 (de)
ES (1) ES2307770T3 (de)
WO (1) WO2004018619A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101712721A (zh) * 2000-06-05 2010-05-26 阿尔托生物科学有限公司 T细胞受体融合物及共轭物以及其使用方法
US8772451B2 (en) * 2003-11-10 2014-07-08 Altor Bioscience Corporation Soluble TCR molecules and methods of use
US7994298B2 (en) 2004-09-24 2011-08-09 Trustees Of Dartmouth College Chimeric NK receptor and methods for treating cancer
CA2777053A1 (en) 2009-10-06 2011-04-14 The Board Of Trustees Of The University Of Illinois Human single-chain t cell receptors
US9273283B2 (en) 2009-10-29 2016-03-01 The Trustees Of Dartmouth College Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
US9181527B2 (en) 2009-10-29 2015-11-10 The Trustees Of Dartmouth College T cell receptor-deficient T cell compositions
US9833476B2 (en) 2011-08-31 2017-12-05 The Trustees Of Dartmouth College NKP30 receptor targeted therapeutics
WO2013169691A1 (en) 2012-05-07 2013-11-14 Trustees Of Dartmouth College Anti-b7-h6 antibody, fusion proteins, and methods of using the same
UA114108C2 (uk) 2012-07-10 2017-04-25 Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання
BR112020006012A2 (pt) * 2017-09-29 2020-10-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services receptores de células t que reconhecem p53 mutado
EP3692058A1 (de) 2017-10-06 2020-08-12 Oslo Universitetssykehus HF Chimäre antigenrezeptoren
CN108060135A (zh) * 2017-12-26 2018-05-22 东莞赛尔生物科技有限公司 一种高效表达p53抑癌蛋白的t细胞、制备方法及应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4867973A (en) * 1984-08-31 1989-09-19 Cytogen Corporation Antibody-therapeutic agent conjugates
US5057313A (en) * 1986-02-25 1991-10-15 The Center For Molecular Medicine And Immunology Diagnostic and therapeutic antibody conjugates
WO1988007553A1 (en) * 1987-03-26 1988-10-06 Teijin Limited Process for preparing antibody complex
AU656518B2 (en) * 1990-02-20 1995-02-09 Coulter Corporation Improved antibody-enzyme direct conjugates and method of making same
GB9200417D0 (en) * 1992-01-09 1992-02-26 Bagshawe Kenneth D Cytotoxic drug therapy
US6399368B1 (en) * 1992-01-17 2002-06-04 Board Of Regents, The University Of Texas System Secretion of T cell receptor fragments from recombinant Escherichia coli cells
ES2139012T3 (es) 1992-05-26 2000-02-01 Univ Leiden Peptidos de la proteina p53 humana destinados para ser utilizados en composiciones que inducen una reaccion en los linfocitos t humanos, y linfocitos t citotoxicos especificos de la proteina p53 humana.
WO1994012520A1 (en) * 1992-11-20 1994-06-09 Enzon, Inc. Linker for linked fusion polypeptides
ES2152424T5 (es) 1994-07-29 2010-07-05 Sunol Molecular Corporation Complejos del mhc y usos de los mismos.
WO1996013593A2 (en) 1994-10-26 1996-05-09 Procept, Inc. Soluble single chain t cell receptors
CA2207736A1 (en) 1994-12-14 1996-06-20 The Scripps Research Institute In vivo activation of tumor-specific cytotoxic t cells
US5830755A (en) * 1995-03-27 1998-11-03 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services T-cell receptors and their use in therapeutic and diagnostic methods
US5869270A (en) 1996-01-31 1999-02-09 Sunol Molecular Corporation Single chain MHC complexes and uses thereof
WO1997032603A1 (en) 1996-03-05 1997-09-12 The Scripps Research Institute Recombinant constructs encoding t cell receptors specific for human hla-restricted tumor antigens
US6127524A (en) 1996-10-18 2000-10-03 Dade Behring Inc. Binding molecules and computer-based methods of increasing the binding affinity thereof
EP0977886A4 (de) 1997-03-07 2002-10-23 Sunol Molecular Corp Fusionsproteine, welche ein bakteriophagen-hüllprotein sowie einen einzelketten t-zell-rezeptor enthalten
CA2305630C (en) 1997-10-02 2012-11-06 Sunol Molecular Corporation Soluble single-chain t-cell receptor proteins
US6534633B1 (en) 1998-10-21 2003-03-18 Altor Bioscience Corporation Polyspecific binding molecules and uses thereof
EP1287363A2 (de) 2000-05-25 2003-03-05 Sunol Molecular Corporation Modulation von wechselwirkungen in t-zellrezeptoren
CN101712721A (zh) 2000-06-05 2010-05-26 阿尔托生物科学有限公司 T细胞受体融合物及共轭物以及其使用方法
DE10109855A1 (de) 2001-03-01 2002-09-12 Stanislawski Thomas Polypeptide eines p53-Protein-spezifischen murinen alpha/beta T-Zell Rezeptors, diese kodierende Nukleinsäuren und deren Verwendung

Also Published As

Publication number Publication date
CA2487779A1 (en) 2004-03-04
EP1546188B1 (de) 2008-08-20
AU2002316190B8 (en) 2009-01-29
US20080269113A1 (en) 2008-10-30
JP4447456B2 (ja) 2010-04-07
EP2009019A1 (de) 2008-12-31
US7456263B2 (en) 2008-11-25
JP2005525128A (ja) 2005-08-25
EP1546188A2 (de) 2005-06-29
AU2002316190A1 (en) 2004-03-17
AU2002316190A8 (en) 2004-04-08
EP1546188A4 (de) 2005-12-21
CN1692124A (zh) 2005-11-02
CN1692124B (zh) 2012-05-30
WO2004018619A2 (en) 2004-03-04
ATE405582T1 (de) 2008-09-15
CA2487779C (en) 2012-10-02
ES2307770T3 (es) 2008-12-01
DE60228504D1 (de) 2008-10-02
WO2004018619A3 (en) 2005-05-06
AU2002316190B2 (en) 2009-01-22

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