CN1690072A - Method for extraction of American ginseng fruit glucoside - Google Patents
Method for extraction of American ginseng fruit glucoside Download PDFInfo
- Publication number
- CN1690072A CN1690072A CN 200410034176 CN200410034176A CN1690072A CN 1690072 A CN1690072 A CN 1690072A CN 200410034176 CN200410034176 CN 200410034176 CN 200410034176 A CN200410034176 A CN 200410034176A CN 1690072 A CN1690072 A CN 1690072A
- Authority
- CN
- China
- Prior art keywords
- panacis quinquefolii
- content
- described method
- glucoside
- fructus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 235000013399 edible fruits Nutrition 0.000 title claims abstract description 7
- 229930182478 glucoside Natural products 0.000 title claims description 14
- 150000008131 glucosides Chemical class 0.000 title claims description 14
- 235000003140 Panax quinquefolius Nutrition 0.000 title abstract description 8
- 240000005373 Panax quinquefolius Species 0.000 title abstract description 7
- 238000000605 extraction Methods 0.000 title 1
- 229930182490 saponin Natural products 0.000 claims abstract description 12
- 150000007949 saponins Chemical class 0.000 claims abstract description 12
- 239000000178 monomer Substances 0.000 claims abstract description 7
- 239000011347 resin Substances 0.000 claims abstract description 6
- 229920005989 resin Polymers 0.000 claims abstract description 6
- 238000001914 filtration Methods 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 14
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 12
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 10
- 239000006228 supernatant Substances 0.000 claims description 4
- 239000007791 liquid phase Substances 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims description 2
- 238000011084 recovery Methods 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims description 2
- 239000004575 stone Substances 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 239000012141 concentrate Substances 0.000 claims 1
- 230000006837 decompression Effects 0.000 claims 1
- 238000010828 elution Methods 0.000 claims 1
- 229920003023 plastic Polymers 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000002002 slurry Substances 0.000 claims 1
- 238000003809 water extraction Methods 0.000 claims 1
- 235000017709 saponins Nutrition 0.000 abstract 2
- 238000004128 high performance liquid chromatography Methods 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 5
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 239000002398 materia medica Substances 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000019636 bitter flavor Nutrition 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- -1 cold soaking 24h Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000021022 fresh fruits Nutrition 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002791 soaking Methods 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Abstract
The invention provides American ginseng fruit saponins based on American ginseng fruit, by extracting, filtering, adsorbing with resin, eluting and spray drying it, the content of American ginseng fruit saponins more than 60 percent, measured the total amount of eight monomers Rg1, Re, Rc, Rg2, Rb1, Rb2, Rb3, Rd by HPLC. Wherein the content of Rb3 is more than 35 percent, while Re is more than 10 percent.
Description
The present invention relates to the extracting method that Fructus Panacis Quinquefolii is processed into Fructus Panacis Quinquefolii glucoside.
Radix Panacis Quinquefolii is Radix Panacis Quinquefolii, American ginseng, U.S.'s genseng etc. again.Originating in the U.S. and Canada, is famous and precious health care medicine, in China's clinical application the earliest, and the applicating history in existing more than 300 year.On the books in clear Kangxu 33 years " complement Essentials of Materia Medica " and clear Qianrong 30 years " herbal outline is picked up any lost article from the road "." property of medicine is examined " states note, and " American ginseng steeps fourth like the white skin of the Liao Dynasty's ginseng, and flavor class genseng is only cold in nature, sweetness and bitterness; Tonifying yin is brought down a fever, and the useful unit of ginger system sets upright gas ".As lung stomach two warps, function is tonifying lung the moon, and born fluid relieves inflammation or internal heat.Chinese materia medica studies have shown that for " ciril disease "---the hypertension etc. of modern society's pilosity, Radix Panacis Quinquefolii has better therapeutic.
Fructus Panacis Quinquefolii is unfavorable for depositing because of existing less, and unique pharmacology health-care effect is arranged.
Fructus Panacis Quinquefolii of the present invention also has the whole effective constituents of Radix Panacis Quinquefolii, and Radix Panacis Quinquefolii saponin monomer Rb3 content exceeds more than 30 times than saponin monomer Rb3 content in the Radix Panacis Quinquefolii, medical research now proves, the Fructus Panacis Quinquefolii saponin has good reducing blood lipid to high fat of blood, but it is big to extract Fructus Panacis Quinquefolii saponin difficulty.Employing orthogonal experiment methods such as Xu Pin have been studied the technology of extracting American ginseng fresh fruit juice, are that really 8 times of cream are advisable with 60% ethanol, cold soaking 24h, solvent consumption. and ethanol consumption is big as a result for this, the cost height is unfavorable for big production.
To utilize tree absorption to improve the content of Fructus Panacis Quinquefolii glucoside in the present invention, mainly solve Fructus Panacis Quinquefolii glucoside and contain low problem.
Show that mainly the Radix Panacis Quinquefolii fruit juice shelf time is short, have only tens day collection period, and be flow-like, perishable especially, be difficult to produce Fructus Panacis Quinquefolii glucoside if extracting method is incorrect, and produce the product saponin monomer and also can change.
Extracting method of the present invention is simple, and is molten easy to operate, and the yield rate height can be produced in batch.
The present invention solves Fructus Panacis Quinquefolii glucoside extracting method problem, and the content raising, for the exploitation other products creates conditions.1.2 tons of Fructus Panacis Quinquefolii glucosides have been produced now.
The present invention is processed into the method for Fructus Panacis Quinquefolii glucoside with Fructus Panacis Quinquefolii, and Fructus Panacis Quinquefolii glucoside detects eight kinds of saponin monomer content more than 60% with the liquid phase look.Rb wherein
3Content is greater than 35%, and Re content is greater than 10%.
Fructus Panacis Quinquefolii glucoside extracting method of the present invention:
Get 1500 kilograms of bright Radix Panacis Quinquefolii mature fruits → clean → mill juice → removals fruit stone → pulp and add and boiled 2 hours 1 ton of poach 2 times → first time, boil for the second time 1 hour → extract supernatant liquor → filtration → pass through macroporous resin column (Hp100) → 1.8 tons of wash-out resins of adding 68-70 degree ethanol → elutriant recovery ethanol → condensed cream spraying drying → Fructus Panacis Quinquefolii glucoside → chemical examination → packing → finished product → warehouse-in out.
Product proterties of the present invention
This product be canescence to the near-white powder, gas is little, mildly bitter flavor, have draw moist.
The Fructus Panacis Quinquefolii saponin detects eight kinds of saponin monomers, Rg with high-efficient liquid phase color
1, Re, Rc, Rg
2, R
B1, R
B2, R
B3, R
d, total content is greater than 60%.Middle Rb
3Content is greater than 35%, and Re content is greater than 10%.
Claims (5)
1, a kind of Fructus Panacis Quinquefolii glucoside extracts process for purification, it is characterized in that this method comprises the following steps:
1), with fresh Fructus Panacis Quinquefolii defibrination, take out seed;
2), with water extraction Fructus Panacis Quinquefolii slurry;
3), extracting solution passes through resin column;
4), also concentrate a recovery ethanol with the decompression jar with ethanol-eluting resin column;
5), spraying drying Fructus Panacis Quinquefolii glucoside
2, according to 1 described method, it is characterized in that said is with machine mill, adds clean water and Radix Panacis Quinquefolii by than 1: 1 defibrination, removes fruit stone.Collect with clean container.
3, in 1 2) described method, be to add 1.5 tons of Radix Panacis Quinquefolii pulps with the multipotency extractor, added 1 ton of water boil again 2 hours, filter, the dregs of a decoction added 1 ton of water boil 1 hour again, filtered.
4, according in 1 3) described method is that filtering supernatant is passed through resin column.
5, according in 1 4) described method, with 1.8 tons of 68-70 degree ethanol elutions, filtering supernatant, concentrating under reduced pressure filtering supernatant proportion is sprayed during for 1.10-1.18.Pack into and seal in the plastics bag.Chemical examination Fructus Panacis Quinquefolii saponin content detects eight kinds of saponin monomers, Rg with high-efficient liquid phase color
1, Re, Rc, Rg
2, T
B1, R
B2R
B3, R
d, total content is greater than 60%, wherein Rb
3Content is greater than 35%, and Re content is greater than 10%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100341765A CN100441592C (en) | 2004-04-27 | 2004-04-27 | Method for extraction of American ginseng fruit glucoside |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100341765A CN100441592C (en) | 2004-04-27 | 2004-04-27 | Method for extraction of American ginseng fruit glucoside |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1690072A true CN1690072A (en) | 2005-11-02 |
| CN100441592C CN100441592C (en) | 2008-12-10 |
Family
ID=35345865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100341765A Expired - Lifetime CN100441592C (en) | 2004-04-27 | 2004-04-27 | Method for extraction of American ginseng fruit glucoside |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100441592C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104983766A (en) * | 2015-07-31 | 2015-10-21 | 集安万泰参业生物有限公司 | Extraction method of American ginseng fruit saponins |
| CN105124567A (en) * | 2015-06-09 | 2015-12-09 | 汉中领维生物科技发展有限公司 | Preparation method and health-care effects of mixture of giant salamander unfertilized egg powder, American ginseng fruits and selenium-enriched tea leaf extract |
| CN108152437A (en) * | 2017-12-06 | 2018-06-12 | 广州卡马生物科技有限公司 | American Ginseng reference extract and its preparation method and application |
| CN109053845A (en) * | 2018-08-30 | 2018-12-21 | 佛山市欧若拉生物科技有限公司 | A kind of American ginseng saponin extraction process |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1325509C (en) * | 2003-07-08 | 2007-07-11 | 李平亚 | Extract of american ginseng fruit saponin, extracting and refining method and medicinal use thereof |
-
2004
- 2004-04-27 CN CNB2004100341765A patent/CN100441592C/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105124567A (en) * | 2015-06-09 | 2015-12-09 | 汉中领维生物科技发展有限公司 | Preparation method and health-care effects of mixture of giant salamander unfertilized egg powder, American ginseng fruits and selenium-enriched tea leaf extract |
| CN104983766A (en) * | 2015-07-31 | 2015-10-21 | 集安万泰参业生物有限公司 | Extraction method of American ginseng fruit saponins |
| CN108152437A (en) * | 2017-12-06 | 2018-06-12 | 广州卡马生物科技有限公司 | American Ginseng reference extract and its preparation method and application |
| CN109053845A (en) * | 2018-08-30 | 2018-12-21 | 佛山市欧若拉生物科技有限公司 | A kind of American ginseng saponin extraction process |
Also Published As
| Publication number | Publication date |
|---|---|
| CN100441592C (en) | 2008-12-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1066055C (en) | Production method for extracting flavonoid compound extract or powder from bamboo leaf | |
| CN105767396A (en) | Lipid-lowering ginkgo seed tea | |
| CN1509619A (en) | Red rooted salvia | |
| CN101606743B (en) | Ganoderma beverage and preparation method thereof | |
| CN101107952B (en) | Yunnan olive health-care tea and preparing method thereof | |
| CN101053407A (en) | Jujube medlar tea and producing technology thereof | |
| CN104921217B (en) | A kind of black fruit fructus lycii, hawthorn, the preparation method of lemon composite beverage | |
| CN102178720A (en) | Method for simultaneously preparing total saponin and polysaccharide from fiveleaf gynostemma herb | |
| CN101965980A (en) | Solid chrysanthemum malt extract and preparation method thereof | |
| CN103992876A (en) | Extraction method of passionflower seed oil | |
| CN101659917A (en) | Truffle wine producing process | |
| CN101284047A (en) | Ginsenoside extract and its extraction method | |
| CN102178004B (en) | Health-care Puer tea drink | |
| CN100441592C (en) | Method for extraction of American ginseng fruit glucoside | |
| CN101107950B (en) | Whitethorn health-care tea and preparing method thereof | |
| CN102805282A (en) | Method for preparing and producing panax quinguefolium polysaccharides peptide | |
| CN1557382A (en) | Glucoside compound preparation and its preparing process | |
| CN103767011A (en) | Plant beverage and preparation method thereof | |
| CN101228958A (en) | Method of extracting amylose and red-yellow pigment from medlar as accretion used for rhodiola rosea beverage | |
| CN1288168C (en) | Polysaccharides compound preparation and method for preparing the same | |
| CN102613347A (en) | Gingko black tea and preparation method thereof | |
| CN100443497C (en) | Method for extraction of ginseng fruit glucoside | |
| CN103431380A (en) | Dietary therapy product capable of reducing myocardium oxygen consumption and increasing coronary blood-flow volume | |
| CN102978091B (en) | Technology for preparing health wine from hippophae rhamnoides and gynostemma pentaphylla | |
| CN114431470A (en) | Astragalus stem and leaf decoction and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CX01 | Expiry of patent term |
Granted publication date: 20081210 |