CN1557382A - Glucoside compound preparation and its preparing process - Google Patents
Glucoside compound preparation and its preparing process Download PDFInfo
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- CN1557382A CN1557382A CNA2004100127140A CN200410012714A CN1557382A CN 1557382 A CN1557382 A CN 1557382A CN A2004100127140 A CNA2004100127140 A CN A2004100127140A CN 200410012714 A CN200410012714 A CN 200410012714A CN 1557382 A CN1557382 A CN 1557382A
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- glycoside compound
- panacis quinquefolii
- ginseng
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- 238000002360 preparation method Methods 0.000 title claims abstract description 30
- -1 Glucoside compound Chemical class 0.000 title claims description 42
- 238000000034 method Methods 0.000 title description 5
- 229930182478 glucoside Natural products 0.000 title 1
- 229930182470 glycoside Natural products 0.000 claims abstract description 33
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 24
- 241000208340 Araliaceae Species 0.000 claims abstract description 23
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 23
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 23
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 23
- 235000008434 ginseng Nutrition 0.000 claims abstract description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000009636 Huang Qi Substances 0.000 claims description 22
- 239000000284 extract Substances 0.000 claims description 15
- 239000002994 raw material Substances 0.000 claims description 13
- 230000001476 alcoholic effect Effects 0.000 claims description 11
- 239000000706 filtrate Substances 0.000 claims description 11
- 239000007788 liquid Substances 0.000 claims description 8
- 239000002775 capsule Substances 0.000 claims description 7
- 238000010992 reflux Methods 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 3
- 235000013361 beverage Nutrition 0.000 claims description 2
- 238000007654 immersion Methods 0.000 claims description 2
- 239000008280 blood Substances 0.000 abstract description 6
- 210000004369 blood Anatomy 0.000 abstract description 6
- 230000017531 blood circulation Effects 0.000 abstract description 5
- 238000000605 extraction Methods 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 150000002338 glycosides Chemical class 0.000 abstract 3
- 240000005373 Panax quinquefolius Species 0.000 abstract 1
- 208000007536 Thrombosis Diseases 0.000 abstract 1
- 229940107666 astragalus root Drugs 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 description 25
- 239000005017 polysaccharide Substances 0.000 description 25
- 150000004676 glycans Chemical class 0.000 description 15
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 13
- 229930182490 saponin Natural products 0.000 description 13
- 150000007949 saponins Chemical class 0.000 description 13
- 239000010413 mother solution Substances 0.000 description 12
- 239000000243 solution Substances 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 9
- 238000001556 precipitation Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 238000003809 water extraction Methods 0.000 description 8
- 239000012567 medical material Substances 0.000 description 7
- 238000002156 mixing Methods 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 238000001816 cooling Methods 0.000 description 4
- 238000002481 ethanol extraction Methods 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 244000241838 Lycium barbarum Species 0.000 description 3
- 235000015459 Lycium barbarum Nutrition 0.000 description 3
- 235000015468 Lycium chinense Nutrition 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000002893 slag Substances 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 208000026106 cerebrovascular disease Diseases 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000036737 immune function Effects 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000001694 spray drying Methods 0.000 description 2
- MQVRGDZCYDEQML-UHFFFAOYSA-N Astragalin Natural products C1=CC(OC)=CC=C1C1=C(OC2C(C(O)C(O)C(CO)O2)O)C(=O)C2=C(O)C=C(O)C=C2O1 MQVRGDZCYDEQML-UHFFFAOYSA-N 0.000 description 1
- 241001061264 Astragalus Species 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- NEEQFPMRODQIKX-REOHCLBHSA-N N(3)-oxalyl-L-2,3-diaminopropionic acid Chemical compound OC(=O)[C@@H](N)CNC(=O)C(O)=O NEEQFPMRODQIKX-REOHCLBHSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 239000006286 aqueous extract Substances 0.000 description 1
- 235000006533 astragalus Nutrition 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 238000012869 ethanol precipitation Methods 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 229930182494 ginsenoside Natural products 0.000 description 1
- 229940089161 ginsenoside Drugs 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- JPUKWEQWGBDDQB-QSOFNFLRSA-N kaempferol 3-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=CC(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O JPUKWEQWGBDDQB-QSOFNFLRSA-N 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000011127 radiochemotherapy Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 210000004233 talus Anatomy 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention is one kind of glycoside preparation and its preparation process. The glycoside preparation is prepared with American ginseng and/or ginseng, astragalus root and notoginseng as material and through extraction with ethanol solution in certain concentration and other steps. The glycoside preparation has the functions of refreshing, improving memory, promoting blood circulation to disperse blood clots, lowering blood sugar and pressure, preventing cardiac and cerebral vascular diseases, etc.
Description
Technical field
The present invention relates to a kind of glycoside compound preparation and preparation method, particularly a kind of is the glycoside compound preparation and the preparation method of raw material with Radix Panacis Quinquefolii and/or Radix Ginseng, the Radix Astragali and Radix Notoginseng.
Background technology
Radix Panacis Quinquefolii or Radix Ginseng, the Radix Astragali and Radix Notoginseng all are the rare Chinese medicines of using always, and these three kinds of medical materials mainly are used as medicine with subterraneous root or root hair.Special Radix Panacis Quinquefolii or Radix Ginseng are taken or directly take the capsule after Radix Panacis Quinquefolii or Radix Ginseng grind carefully after the direct water of people is stewed usually.In fact Radix Panacis Quinquefolii or Radix Ginseng contain two effective constituents: Radix Panacis Quinquefolii or ginsenoside, Radix Panacis Quinquefolii or ginseng polysaccharide; The Radix Astragali contains three effective constituents: astragalin, Radix Astragali flavone and astragalus polysaccharides; Radix Notoginseng contains three kinds of main components: arasaponin, dencichine and Radix Notoginseng polysaccharide.Because the effect of glycoside compound and polysaccharide compound differs greatly, glycoside compound mainly is a refreshment, fatigue recovery, and improving memory, activating blood circulation to dissipate blood stasis, blood circulation promoting, blood sugar lowering and blood pressure prevent cardio-cerebrovascular diseases.Polysaccharide compound mainly is to improve immunologic function and blood fat reducing.And in the root or root hair of Radix Panacis Quinquefolii or Radix Ginseng, use ethanol extraction, its extract productive rate is at 15-24%, and in the alcohol extract saponin content at 10-30%.And Radix Panacis Quinquefolii or ginseng polysaccharide's content 1-3%.Directly use hot water extraction, its extract productive rate is at 15-20%, and in the water extract saponin content at 10-25%, and Radix Panacis Quinquefolii or ginseng polysaccharide's content 4-10%.Two kinds of method extracts all are the saponin content height, because the saponin content height, people take the effect of only playing Saponin behind this extract, and the immune effect of polysaccharide is not obvious.Especially ethanol extraction is based on Saponin.Other the Radix Astragali and Radix Notoginseng also are like this.So always the expectation a kind of easy method is arranged, allow this four the flavor Chinese medicine, the main component glycoside compound of Radix Panacis Quinquefolii, Radix Ginseng, the Radix Astragali and Radix Notoginseng separates with polysaccharide compound.
Nearest disclosed patent CN 1168383A, this patent application document discloses a kind of preparation method of extract: directly use hot water extraction, extract Radix Ginseng, Radix Panacis Quinquefolii Saponin and polysaccharide with uniting of ethanol precipitation then, because they have only used one step of water extraction, the relatively poor Saponin extraction ratio of solubility in Radix Ginseng, the Radix Panacis Quinquefolii is low, and the saponin content height of aqueous extract causes Saponin difficult with separating of polysaccharide, and the ethanol consumption is big.
Summary of the invention
The defective that purpose of the present invention mixes for Saponin and polysaccharide in the extract of the Radix Panacis Quinquefolii that overcomes above-mentioned existence and/or Radix Ginseng, the Radix Astragali and Radix Notoginseng, a kind of glycoside compound preparation and preparation method are provided, the present invention uses ethanol extraction earlier, the two-step method of reuse water extraction, Saponin extraction ratio height not only, and reduced the step of precipitate and separate polysaccharide, the productive rate of polysaccharide and purity have all been improved, and effectively Saponin and separation of polysaccharides are come.Usually glycoside compound has certain excitation to be not suitable for children taking, can select appropriate formulation to take according to different human needs like this.
A kind of glycoside compound preparation: be to make by following raw materials by weight:
Radix Panacis Quinquefolii and/or Radix Ginseng 50%-70% Radix Astragali 20%-30%
Radix Notoginseng 10-20%.
The preparation method of above-mentioned glycoside compound preparation: get above-mentioned Radix Panacis Quinquefolii and/or Radix Ginseng, the Radix Astragali and Radix Notoginseng raw material by constant weight percentage ratio, and,, filter then 50-100 ℃ of following reflux, extract, with in it immersion 50-100% alcohol solvent, filtrate is concentrated, and drying makes glycoside compound; A certain amount of Fructus Lycii of adding in filtering residue, one reinstates hot water extraction, treats that boiling reflux is abundant, and cooling, filtration reconcentration add 80% alcoholic solution precipitation then, leach precipitation, and the precipitation that will leach is dried, pulverizing, makes polysaccharide compound.
The above-mentioned glycoside compound of producing can be made capsule, beverage and oral liquid.
The present invention passes through ethanol extraction method.Agents useful for same is nontoxic, and is easy to operate, and technology is simple, and used all is common apparatus.The present invention makes glycoside compound from Radix Panacis Quinquefolii and/or Radix Ginseng, the Radix Astragali and Radix Notoginseng Chinese medicine.Contain the 0.1-1.0% polysaccharide compound in the glycoside compound.
The specific embodiment
Embodiment 1
Canada produces Radix Panacis Quinquefolii trepang root hair 70kg, and dried Radix Astragali 20kg is produced in Hebei, and dried Radix Notoginseng 10kg is produced in Yunnan, pulverizes together, adds 80% alcoholic solution, and the solid-to-liquid ratio i.e. weight of all dried medical materials and the volume ratio of 80% alcoholic solution is 1: 8, at 1.5m
3Reactor in, back flow reaction is 6 hours under the fluidized state, back flow reaction twice, merging filtrate becomes about 1450 liters of mother solution (1); Add Ningxia and produce dry wolfberry 10kg with extracting slag, use hot water extraction, the solid-to-liquid ratio i.e. weight of all dried medical materials and the weight ratio of water is 1: 10, at 1.5m
3Reactor in, back flow reaction is 6 hours under the fluidized state, after the cooling, with filter press filtrate extract about 760 liters, be concentrated into about 100 liters, add 100 liter 80% alcoholic solution precipitation, leach precipitation, oven dry, pulverize, get water solublity mixing polysaccharide 4.84kg, it is a kind of with Radix Panacis Quinquefolii, the Radix Astragali, Radix Notoginseng and Fructus Lycii are raw material, the mixing polysaccharide compounds preparation that glycoside compound content is very little, and it has very strong immunologic function, to weak and sickly, easily irritated, serious disease rehabilitation, care of aged, antitumor etc. particularly all have tangible effect to the rehabilitation behind cancer patient's chemotherapy radiotherapy; About 190 liters of its filtrate merges formation mother solution (2) about 1640 liters with mother solution (1), and mother solution (2) is concentrated into about 100 liters, add edible silica white 6kg, shake up the back spray drying, obtain 23.8kg, it is a kind of with Radix Panacis Quinquefolii, the Radix Astragali and Radix Notoginseng are the mixed glycosides compound formulation of raw material, and it has refreshment, improving memory, activating blood circulation to dissipate blood stasis, blood circulation promoting, blood glucose and blood pressure prevent cardiovascular and cerebrovascular disease etc.The mixed glycosides chemical compound of gained and mixing polysaccharide compounds are put into capsule respectively No. 1.Every dress of mixed glycosides chemical compound capsule 1g spray drying powder, and every dress of mixing polysaccharide compounds capsule 0.1g xeraphium.Recommended dose, mixed glycosides chemical compound capsule is crowd more than 14 years old, and day clothes twice each two.
Embodiment 2
Homemade Radix Panacis Quinquefolii trepang root hair 70g, dried Radix Astragali 20g is produced in Hebei, dried Radix Notoginseng 10g is produced in Yunnan, pulverize together, add 80% alcoholic solution, the solid-to-liquid ratio i.e. weight of all dried medical materials and the volume ratio of 80% alcoholic solution is 1: 8, in 2 liters flask, back flow reaction is 4 hours under the fluidized state, back flow reaction twice, and merging filtrate becomes about 1.4 liters of mother solution (1); Add Ningxia and produce dry wolfberry 10g with extracting slag, use hot water extraction, the solid-to-liquid ratio i.e. weight of all dried medical materials and the weight ratio of water is 1: 10, in 2 liters flask, back flow reaction is 4 hours under the fluidized state, after the cooling, about 740 milliliters of filtrate extract is concentrated into about 100 milliliters, add 100 milliliter 80% alcoholic solution precipitation, leach precipitation, oven dry is pulverized, get water solublity mixing polysaccharide 5.25g, it is a kind of with Radix Panacis Quinquefolii, the Radix Astragali, and Radix Notoginseng and Fructus Lycii are the very little polysaccharide compound preparation of raw material glycoside compound content; About 200 milliliters of its filtrate merges formation mother solution (2) about 1600 milliliters with mother solution (1), and mother solution (2) is concentrated into dried, obtains 24.4g, and it is a kind of with Radix Panacis Quinquefolii, and the Radix Astragali and Radix Notoginseng are the glycoside compound preparation of raw material.Product has identical effect with embodiment 1 product.
Embodiment 3
Homemade Radix Ginseng trepang root hair 70g, dried Radix Astragali 20g is produced in Hebei, dried Radix Notoginseng 10g is produced in Yunnan, pulverizes together, adds 80% alcoholic solution, the solid-to-liquid ratio i.e. weight of all dried medical materials and the volume ratio of 80% alcoholic solution is 1: 8, in 2 liters flask, back flow reaction is 4 hours under the fluidized state, twice of back flow reaction, merging filtrate becomes about 1.4 liters of mother solution (1), add Ningxia and produce dry wolfberry 10g with extracting slag, use hot water extraction, the solid-to-liquid ratio i.e. weight of all dried medical materials and the weight ratio of water is 1: 10, in 2 liters flask, back flow reaction is 4 hours under the fluidized state, after the cooling, and about 720 milliliters of filtrate extract, be concentrated into about 100 milliliters, add 100 milliliter 80% alcoholic solution precipitation, leach precipitation, oven dry, pulverize, get water solublity mixing polysaccharide 4.86g, it is a kind of with Radix Ginseng, the Radix Astragali, Radix Notoginseng and Fructus Lycii are raw material, the polysaccharide compound preparation that glycoside compound content is very little; About 180 milliliters of its filtrate merges formation mother solution (2) about 1580 milliliters with mother solution (1); Mother solution (2) is concentrated into dried, obtains 25.9g, and it is a kind of with Radix Ginseng, and the Radix Astragali and Radix Notoginseng are the glycoside compound preparation of raw material.Product has identical effect with embodiment 1 product.
Claims (5)
1, a kind of glycoside compound preparation: be to make by following raw materials by weight:
Radix Panacis Quinquefolii and/or Radix Ginseng 50%-70% Radix Astragali 20%-30%
Radix Notoginseng 10-20%.
2, according to the preparation method of the described glycoside compound preparation of claim 1, it is characterized in that: get above-mentioned Radix Panacis Quinquefolii and/or Radix Ginseng, the Radix Astragali, Radix Notoginseng raw material by constant weight percentage ratio, and with in it immersion 50-100% alcohol solvent, 50-100 ℃ of following reflux, extract,, filter then, filtrate is concentrated, dry, make glycoside compound.
3, according to the preparation method of the described glycoside compound preparation of claim 2, it is characterized in that: the Radix Panacis Quinquefolii of adding and/or Radix Ginseng, the Radix Astragali, Radix Notoginseng raw material are 1 with alcoholic solution bulking value kg/l ratio: 5-1: 15.
4, according to the preparation method of the described glycoside compound preparation of claim 2, it is characterized in that: raw material in alcohol solvent reflux, extract, 1-8 hour.
5, according to the described glycoside compound preparation of claim 1, it is characterized in that: the above-mentioned glycoside compound of producing can be made capsule, beverage and oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100127140A CN100400064C (en) | 2004-02-11 | 2004-02-11 | Glucoside compound preparation and its preparing process |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100127140A CN100400064C (en) | 2004-02-11 | 2004-02-11 | Glucoside compound preparation and its preparing process |
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| CN1557382A true CN1557382A (en) | 2004-12-29 |
| CN100400064C CN100400064C (en) | 2008-07-09 |
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| CNB2004100127140A Expired - Fee Related CN100400064C (en) | 2004-02-11 | 2004-02-11 | Glucoside compound preparation and its preparing process |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647840B (en) * | 2008-08-13 | 2012-04-18 | 韶安生物科技股份有限公司 | Chinese herbal medicine composition for controlling metabolic syndrome and preparation method thereof |
| CN103169778A (en) * | 2013-03-12 | 2013-06-26 | 张成全 | Medicament for treating lung cancer and preparation method thereof |
| CN103381245A (en) * | 2013-06-27 | 2013-11-06 | 陶殿华 | Traditional Chinese medicine used for adjuvant therapy of hypertension and preparation method thereof |
| CN104257738A (en) * | 2014-09-30 | 2015-01-07 | 丁延强 | Xinnaotong traditional Chinese medicine preparation for treating coronary heart diseases |
| CN104258034A (en) * | 2014-09-11 | 2015-01-07 | 上海焦点生物技术有限公司 | Traditional Chinese medicine composition for boosting immunity |
| CN104435080A (en) * | 2014-11-10 | 2015-03-25 | 成都果睿医药科技有限公司 | Ginseng-containing pharmaceutical composition for treating cardiovascular and cerebrovascular diseases |
| CN105535553A (en) * | 2016-03-10 | 2016-05-04 | 厦门塔斯曼生物工程有限公司 | Formula for regulating blood sugar of human body |
| CN106266573A (en) * | 2016-09-27 | 2017-01-04 | 杭州本草养正堂生物科技有限公司 | A kind of resisting fatigue, the compound preparation and preparation method thereof of defying age |
| CN111053823A (en) * | 2020-01-20 | 2020-04-24 | 洪金盛 | A Chinese medicinal composition for regulating hypertension, and its preparation method |
| CN111084848A (en) * | 2020-02-13 | 2020-05-01 | 陈金玉 | Heart protecting pill for reinforcing primordial qi and regulating viscera and preparation method thereof |
| CN111838482A (en) * | 2020-07-20 | 2020-10-30 | 安徽康之味生物科技有限公司 | Preparation process of long-acting anti-fatigue salt carbonated water |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1084071A (en) * | 1992-09-15 | 1994-03-23 | 连汝安 | A kind of production method of Chinese medicine oral liquid |
| CN1426787A (en) * | 2001-12-20 | 2003-07-02 | 肖永良 | Health care mixture for antifatigne and enhancing immunity |
-
2004
- 2004-02-11 CN CNB2004100127140A patent/CN100400064C/en not_active Expired - Fee Related
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101647840B (en) * | 2008-08-13 | 2012-04-18 | 韶安生物科技股份有限公司 | Chinese herbal medicine composition for controlling metabolic syndrome and preparation method thereof |
| CN103169778A (en) * | 2013-03-12 | 2013-06-26 | 张成全 | Medicament for treating lung cancer and preparation method thereof |
| CN103169778B (en) * | 2013-03-12 | 2015-07-22 | 张成全 | Medicament for treating lung cancer and preparation method thereof |
| CN103381245A (en) * | 2013-06-27 | 2013-11-06 | 陶殿华 | Traditional Chinese medicine used for adjuvant therapy of hypertension and preparation method thereof |
| CN104258034A (en) * | 2014-09-11 | 2015-01-07 | 上海焦点生物技术有限公司 | Traditional Chinese medicine composition for boosting immunity |
| CN104257738A (en) * | 2014-09-30 | 2015-01-07 | 丁延强 | Xinnaotong traditional Chinese medicine preparation for treating coronary heart diseases |
| CN104435080A (en) * | 2014-11-10 | 2015-03-25 | 成都果睿医药科技有限公司 | Ginseng-containing pharmaceutical composition for treating cardiovascular and cerebrovascular diseases |
| CN105535553A (en) * | 2016-03-10 | 2016-05-04 | 厦门塔斯曼生物工程有限公司 | Formula for regulating blood sugar of human body |
| CN106266573A (en) * | 2016-09-27 | 2017-01-04 | 杭州本草养正堂生物科技有限公司 | A kind of resisting fatigue, the compound preparation and preparation method thereof of defying age |
| CN111053823A (en) * | 2020-01-20 | 2020-04-24 | 洪金盛 | A Chinese medicinal composition for regulating hypertension, and its preparation method |
| CN111084848A (en) * | 2020-02-13 | 2020-05-01 | 陈金玉 | Heart protecting pill for reinforcing primordial qi and regulating viscera and preparation method thereof |
| CN111838482A (en) * | 2020-07-20 | 2020-10-30 | 安徽康之味生物科技有限公司 | Preparation process of long-acting anti-fatigue salt carbonated water |
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| CN100400064C (en) | 2008-07-09 |
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