CN1655671A - 毒理学和剂量预测的动物模型 - Google Patents

毒理学和剂量预测的动物模型 Download PDF

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Publication number
CN1655671A
CN1655671A CNA038124866A CN03812486A CN1655671A CN 1655671 A CN1655671 A CN 1655671A CN A038124866 A CNA038124866 A CN A038124866A CN 03812486 A CN03812486 A CN 03812486A CN 1655671 A CN1655671 A CN 1655671A
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CN
China
Prior art keywords
tissue
animal
target
normal
diseased
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA038124866A
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English (en)
Chinese (zh)
Inventor
J·P·马瑟
P·F·扬
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RAVAN BOITECHNOLOGIES Inc
Original Assignee
RAVAN BOITECHNOLOGIES Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RAVAN BOITECHNOLOGIES Inc filed Critical RAVAN BOITECHNOLOGIES Inc
Publication of CN1655671A publication Critical patent/CN1655671A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/30—Bird
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Environmental Sciences (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CNA038124866A 2002-05-30 2003-05-30 毒理学和剂量预测的动物模型 Pending CN1655671A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38471502P 2002-05-30 2002-05-30
US60/384,715 2002-05-30

Publications (1)

Publication Number Publication Date
CN1655671A true CN1655671A (zh) 2005-08-17

Family

ID=29712081

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA038124866A Pending CN1655671A (zh) 2002-05-30 2003-05-30 毒理学和剂量预测的动物模型

Country Status (11)

Country Link
US (2) US20040045045A1 (https=)
EP (1) EP1507454A4 (https=)
JP (1) JP4304309B2 (https=)
KR (1) KR20050004263A (https=)
CN (1) CN1655671A (https=)
AU (1) AU2003249675B2 (https=)
CA (1) CA2486548A1 (https=)
IL (2) IL165128A (https=)
MX (1) MXPA04011828A (https=)
NZ (1) NZ536553A (https=)
WO (1) WO2003101187A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107921173A (zh) * 2015-08-03 2018-04-17 富士胶片株式会社 细胞结构体、非人模型动物、非人模型动物的制造方法及被检验物质的评价方法
CN114711192A (zh) * 2022-04-13 2022-07-08 中国科学院西北高原生物研究所 一种长效抑郁症动物模型的构建试剂盒及构建方法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7148038B2 (en) * 2001-10-16 2006-12-12 Raven Biotechnologies, Inc. Antibodies that bind to cancer-associated antigen CD46 and methods of use thereof
GB0427916D0 (en) * 2004-12-21 2005-01-19 Astrazeneca Ab Method
RU2325641C1 (ru) * 2006-11-20 2008-05-27 Наталья Александровна Уракова Способ экспресс-оценки степени безопасности лекарственных средств для инъекций
US8628554B2 (en) 2010-06-13 2014-01-14 Virender K. Sharma Intragastric device for treating obesity
US9526648B2 (en) 2010-06-13 2016-12-27 Synerz Medical, Inc. Intragastric device for treating obesity
US10010439B2 (en) 2010-06-13 2018-07-03 Synerz Medical, Inc. Intragastric device for treating obesity
US10420665B2 (en) 2010-06-13 2019-09-24 W. L. Gore & Associates, Inc. Intragastric device for treating obesity
US10779980B2 (en) 2016-04-27 2020-09-22 Synerz Medical, Inc. Intragastric device for treating obesity
KR101920048B1 (ko) * 2016-10-17 2018-11-19 건국대학교 산학협력단 피부 독성 평가용 지렁이 동물모델 및 이를 이용한 인간 피부 독성 평가방법
JP7478720B2 (ja) * 2018-04-13 2024-05-07 シャンハイ エルアイディーイー バイオテック カンパニー リミテッド 条件付き再プログラム化細胞から動物モデルを得るための方法および抗腫瘍薬のスクリーニングのための動物モデルの使用
CN117016488B (zh) * 2023-08-16 2025-09-16 中国水产科学研究院淡水渔业研究中心 一种大口黑鲈xy型遗传雄鱼性反转为xy型伪雌鱼的诱导剂及诱导方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476996A (en) * 1988-06-14 1995-12-19 Lidak Pharmaceuticals Human immune system in non-human animal
KR950701230A (ko) * 1993-03-04 1995-03-23 죤제이 쉬바르츠 작은 동물 전이모델(small animal metastasis model)
US5698413A (en) * 1993-05-05 1997-12-16 The United States Of America As Represented By The Department Of Health And Human Services Method of evaluating chemotherapeutic agents in vivo
US6416999B1 (en) * 2000-04-07 2002-07-09 Raven Biotechnologies, Inc. Human Müllerian duct-derived epithelial cells and methods of isolation and uses thereof
US6436704B1 (en) * 2000-04-10 2002-08-20 Raven Biotechnologies, Inc. Human pancreatic epithelial progenitor cells and methods of isolation and use thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107921173A (zh) * 2015-08-03 2018-04-17 富士胶片株式会社 细胞结构体、非人模型动物、非人模型动物的制造方法及被检验物质的评价方法
CN114711192A (zh) * 2022-04-13 2022-07-08 中国科学院西北高原生物研究所 一种长效抑郁症动物模型的构建试剂盒及构建方法
CN114711192B (zh) * 2022-04-13 2022-11-29 中国科学院西北高原生物研究所 一种长效抑郁症动物模型的构建试剂盒及构建方法

Also Published As

Publication number Publication date
AU2003249675A1 (en) 2003-12-19
JP4304309B2 (ja) 2009-07-29
JP2005527226A (ja) 2005-09-15
WO2003101187A1 (en) 2003-12-11
EP1507454A4 (en) 2007-11-21
US20040045045A1 (en) 2004-03-04
US20120110682A1 (en) 2012-05-03
NZ536553A (en) 2008-10-31
EP1507454A1 (en) 2005-02-23
IL165128A (en) 2010-12-30
MXPA04011828A (es) 2005-11-23
CA2486548A1 (en) 2003-12-11
IL207587A (en) 2011-08-31
IL165128A0 (en) 2005-12-18
KR20050004263A (ko) 2005-01-12
AU2003249675B2 (en) 2008-06-05

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