CN1649612B - 细胞分化的诱导方法 - Google Patents

细胞分化的诱导方法 Download PDF

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Publication number
CN1649612B
CN1649612B CN038094959A CN03809495A CN1649612B CN 1649612 B CN1649612 B CN 1649612B CN 038094959 A CN038094959 A CN 038094959A CN 03809495 A CN03809495 A CN 03809495A CN 1649612 B CN1649612 B CN 1649612B
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CN
China
Prior art keywords
dicarbamine
cells
chemotherapy
tumor
days
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CN038094959A
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English (en)
Chinese (zh)
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CN1649612A (zh
Inventor
弗拉迪米尔·叶夫根尼耶维奇·涅博利辛
维拉·安德列芙娜·戈尔布诺娃
伊万·德米特耶维奇·特里斯查林
纳坦·坦弗列维奇·赖赫林
奥古斯特·米哈伊洛维奇·加林
马克·鲍里索维奇·贝奇科夫
伊莲娜·米哈伊洛芙娜·特里斯查林娜
加利娜·亚历山德罗芙娜·热尔图金娜
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vladimir Yevgeniyevich Neborisin
Valenta Pharmaceuticals JSC
Original Assignee
OBSCHESTVO S OGRANICHENNOI OTV
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
CN038094959A 2002-02-28 2003-02-28 细胞分化的诱导方法 Expired - Lifetime CN1649612B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RU2002105392 2002-02-28
RU2002105392/14A RU2217196C2 (ru) 2002-02-28 2002-02-28 Способ индукции дифференцировки клеток
PCT/RU2003/000072 WO2003072124A1 (en) 2002-02-28 2003-02-28 Induction method for cell differentiation

Publications (2)

Publication Number Publication Date
CN1649612A CN1649612A (zh) 2005-08-03
CN1649612B true CN1649612B (zh) 2011-04-06

Family

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Family Applications (1)

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CN038094959A Expired - Lifetime CN1649612B (zh) 2002-02-28 2003-02-28 细胞分化的诱导方法

Country Status (18)

Country Link
US (1) US7759313B2 (enExample)
EP (1) EP1491206B9 (enExample)
JP (1) JP4711626B2 (enExample)
CN (1) CN1649612B (enExample)
AT (1) ATE488234T1 (enExample)
AU (1) AU2003235538A1 (enExample)
CY (1) CY1111265T1 (enExample)
DE (1) DE60334978D1 (enExample)
DK (1) DK1491206T3 (enExample)
EA (1) EA007474B1 (enExample)
ES (1) ES2356308T3 (enExample)
HK (1) HK1079990B (enExample)
IL (3) IL163763A0 (enExample)
PT (1) PT1491206E (enExample)
RU (1) RU2217196C2 (enExample)
SI (1) SI1491206T1 (enExample)
UA (1) UA85039C2 (enExample)
WO (1) WO2003072124A1 (enExample)

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MC200060A1 (fr) 2002-10-04 2003-05-28 M Exsymol Sa Produit de couplage entre la tryptamine et un alpha-aminoacide son procédé de préparation et son application dans le domaine de la neuro-cosmétique
RU2335495C2 (ru) 2005-06-15 2008-10-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" N-ацильные производные аминокислот, их фармацевтически приемлевые соли, фармацевтическая композиция и применение в качестве гиполипидемических средств
RU2406727C2 (ru) * 2008-02-13 2010-12-20 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Фармацевтическая композиция, содержащая n-ацильные производные аминокислот, и их применение в качестве противоаллергических, антианафилактических и противовоспалительных средств
RU2378284C2 (ru) * 2008-02-13 2010-01-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Способы получения n-ацильных производных аминокислот (варианты)
RU2373934C1 (ru) * 2008-03-19 2009-11-27 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Применение производных глутаровой кислоты или их фармацевтически приемлемых солей в качестве противоаритмических средств
RU2359030C1 (ru) * 2008-03-19 2009-06-20 Общество С Ограниченной Ответственностью "Лаборатория Клеточных Технологий" Способ получения эндотелиальных клеток из эмбриональных стволовых клеток человека (варианты)
JP5370957B2 (ja) 2008-08-20 2013-12-18 学校法人日本大学 アポトーシス抑制剤
ES2670618T3 (es) * 2010-10-22 2018-05-31 Corum Inc. Derivados de glicina que inhiben la producción de melanina y composición de blanqueamiento de los mismos
CN104257515B (zh) * 2010-10-22 2017-05-03 新钰生技股份有限公司 具有抑制黑色素生成的甘胺酸衍生物及使用其的美白组成物
UA115431C2 (uk) * 2011-10-11 2017-11-10 Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" Застосування глутарилгістаміну для лікування захворювань дихальних шляхів
CN103382179A (zh) * 2013-06-05 2013-11-06 四川百利药业有限责任公司 英加韦林的多晶型物及其制备方法
RU2628800C2 (ru) * 2014-03-12 2017-08-22 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Амидные соединения, способы получения, применение в качестве средств для лечения и профилактики заболеваний, вызываемых рнк-содержащими вирусами
WO2020064832A1 (en) * 2018-09-25 2020-04-02 Myelo Therapeutics Gmbh Imidazolyl ethanamide pentandioic acid for use in therapy of symptoms related to exposure to lethal radiation
RU2726119C1 (ru) * 2019-11-22 2020-07-09 Общество С Ограниченной Ответственностью "Валента - Интеллект" Новые производные полиолов, их применение, фармацевтическая композиция на их основе

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1020179A2 (en) * 1997-07-04 2000-07-19 Vladimir Evgenievich Nebolsin Peptide derivatives or pharmaceutically acceptable salts thereof, method for producing the same, use of said derivatives and pharmaceutical composition

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JPS6016926A (ja) * 1983-07-06 1985-01-28 Kaneshiro Nagai 抗腫瘍剤
JPS6016934A (ja) * 1983-07-06 1985-01-28 Kaneshiro Nagai 抗腫瘍剤
US4816442A (en) * 1986-11-07 1989-03-28 Collagen Corporation Method of inhibiting tumor growth sensitive to CIF-βtreatment
JPS6442430A (en) 1987-08-11 1989-02-14 Nippon Univ Side effect remover for chemotherapeutic agent
US5350836A (en) * 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
JPH0585942A (ja) * 1991-02-26 1993-04-06 Denki Kagaku Kogyo Kk インターフエロン−ヒアルロン酸及び／又はその塩の結合体
MY128261A (en) * 1992-10-27 2007-01-31 Merck Sharp & Dohme New substituted azetidinones as anti-inflammatory and antidegenerative agents
GB9308695D0 (en) * 1993-04-27 1993-06-09 Celltech Ltd Peptidyl derivatives
IL110296A (en) * 1993-07-16 1999-12-31 Smithkline Beecham Corp Imidazole compounds process for their preparation and pharmaceutical compositions containing them
AU696167B2 (en) 1993-10-29 1998-09-03 Trustees Of Boston University Physiologically stable compositions of butyric acid, and butyric acid salts and derivatives as anti-neoplastic agents
JP3517274B2 (ja) * 1994-05-20 2004-04-12 株式会社ナリス化粧品 皮膚組成物
RU2120298C1 (ru) * 1995-11-28 1998-10-20 Товарищество с ограниченной ответственностью "Верта" Иммуностимулятор и препарат на его основе
FR2762315B1 (fr) * 1997-04-22 1999-05-28 Logeais Labor Jacques Derives d'amino-acides inhibiteurs des metalloproteases de la matrice extracellulaire et de la liberation du tnf alpha
CA2308373A1 (en) * 1997-11-07 1999-05-20 Mayo Foundation For Medical Education And Research Interferon immunotherapy
US6838436B1 (en) * 1998-07-10 2005-01-04 Osteoscreen Inc. Inhibitors of proteasomal activity for stimulating bone growth
EP1117778A2 (en) 1998-10-02 2001-07-25 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Methods and compositions for inducing differentiation and apoptosis in cells that overexpress the notch protein

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1020179A2 (en) * 1997-07-04 2000-07-19 Vladimir Evgenievich Nebolsin Peptide derivatives or pharmaceutically acceptable salts thereof, method for producing the same, use of said derivatives and pharmaceutical composition

Also Published As

Publication number Publication date
HK1079990B (zh) 2011-12-09
CN1649612A (zh) 2005-08-03
HK1079990A1 (en) 2006-04-21
IL209653A0 (en) 2011-02-28
WO2003072124A1 (en) 2003-09-04
PT1491206E (pt) 2011-02-11
IL163763A (en) 2011-12-29
DE60334978D1 (de) 2010-12-30
EP1491206B9 (en) 2011-03-09
EA007474B1 (ru) 2006-10-27
UA85039C2 (uk) 2008-12-25
EP1491206A4 (en) 2006-01-11
CY1111265T1 (el) 2015-08-05
EA200401105A1 (ru) 2004-12-30
DK1491206T3 (da) 2011-03-14
US20050180953A1 (en) 2005-08-18
EP1491206A1 (en) 2004-12-29
SI1491206T1 (sl) 2011-03-31
JP2005532269A (ja) 2005-10-27
IL163763A0 (en) 2005-12-18
EP1491206B1 (en) 2010-11-17
AU2003235538A1 (en) 2003-09-09
RU2217196C2 (ru) 2003-11-27
US7759313B2 (en) 2010-07-20
JP4711626B2 (ja) 2011-06-29
ES2356308T3 (es) 2011-04-06
ATE488234T1 (de) 2010-12-15

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