DE60334978D1 - Verwendung von peptidderivaten zum induzieren der zelldifferenzierung - Google Patents
Verwendung von peptidderivaten zum induzieren der zelldifferenzierungInfo
- Publication number
- DE60334978D1 DE60334978D1 DE60334978T DE60334978T DE60334978D1 DE 60334978 D1 DE60334978 D1 DE 60334978D1 DE 60334978 T DE60334978 T DE 60334978T DE 60334978 T DE60334978 T DE 60334978T DE 60334978 D1 DE60334978 D1 DE 60334978D1
- Authority
- DE
- Germany
- Prior art keywords
- group
- cooh
- cell differentiation
- inducing cell
- hydrocarbyl substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000024245 cell differentiation Effects 0.000 title abstract 4
- 230000001939 inductive effect Effects 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 4
- 125000004442 acylamino group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 3
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- 210000002780 melanosome Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- KZIMLUFVKJLCCH-UHFFFAOYSA-N 5-[2-(1h-imidazol-5-yl)ethylamino]-5-oxopentanoic acid Chemical compound OC(=O)CCCC(=O)NCCC1=CNC=N1 KZIMLUFVKJLCCH-UHFFFAOYSA-N 0.000 abstract 1
- 241000699660 Mus musculus Species 0.000 abstract 1
- 125000003368 amide group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- -1 cyclic imide Chemical class 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000003304 gavage Methods 0.000 abstract 1
- 239000000411 inducer Substances 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 201000001441 melanoma Diseases 0.000 abstract 1
- 238000011580 nude mouse model Methods 0.000 abstract 1
- 210000004881 tumor cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2002105392/14A RU2217196C2 (ru) | 2002-02-28 | 2002-02-28 | Способ индукции дифференцировки клеток |
| PCT/RU2003/000072 WO2003072124A1 (en) | 2002-02-28 | 2003-02-28 | Induction method for cell differentiation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60334978D1 true DE60334978D1 (de) | 2010-12-30 |
Family
ID=27764932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60334978T Expired - Lifetime DE60334978D1 (de) | 2002-02-28 | 2003-02-28 | Verwendung von peptidderivaten zum induzieren der zelldifferenzierung |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7759313B2 (enExample) |
| EP (1) | EP1491206B9 (enExample) |
| JP (1) | JP4711626B2 (enExample) |
| CN (1) | CN1649612B (enExample) |
| AT (1) | ATE488234T1 (enExample) |
| AU (1) | AU2003235538A1 (enExample) |
| CY (1) | CY1111265T1 (enExample) |
| DE (1) | DE60334978D1 (enExample) |
| DK (1) | DK1491206T3 (enExample) |
| EA (1) | EA007474B1 (enExample) |
| ES (1) | ES2356308T3 (enExample) |
| HK (1) | HK1079990B (enExample) |
| IL (3) | IL163763A0 (enExample) |
| PT (1) | PT1491206E (enExample) |
| RU (1) | RU2217196C2 (enExample) |
| SI (1) | SI1491206T1 (enExample) |
| UA (1) | UA85039C2 (enExample) |
| WO (1) | WO2003072124A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MC200060A1 (fr) | 2002-10-04 | 2003-05-28 | M Exsymol Sa | Produit de couplage entre la tryptamine et un alpha-aminoacide son procédé de préparation et son application dans le domaine de la neuro-cosmétique |
| RU2335495C2 (ru) * | 2005-06-15 | 2008-10-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | N-ацильные производные аминокислот, их фармацевтически приемлевые соли, фармацевтическая композиция и применение в качестве гиполипидемических средств |
| RU2406727C2 (ru) * | 2008-02-13 | 2010-12-20 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Фармацевтическая композиция, содержащая n-ацильные производные аминокислот, и их применение в качестве противоаллергических, антианафилактических и противовоспалительных средств |
| RU2378284C2 (ru) * | 2008-02-13 | 2010-01-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Способы получения n-ацильных производных аминокислот (варианты) |
| RU2359030C1 (ru) * | 2008-03-19 | 2009-06-20 | Общество С Ограниченной Ответственностью "Лаборатория Клеточных Технологий" | Способ получения эндотелиальных клеток из эмбриональных стволовых клеток человека (варианты) |
| RU2373934C1 (ru) | 2008-03-19 | 2009-11-27 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Применение производных глутаровой кислоты или их фармацевтически приемлемых солей в качестве противоаритмических средств |
| JP5370957B2 (ja) * | 2008-08-20 | 2013-12-18 | 学校法人日本大学 | アポトーシス抑制剤 |
| KR101414942B1 (ko) * | 2010-10-22 | 2014-07-04 | 코럼 아이엔씨 | 멜라닌 생성을 억제하는 글리신 유도체 및 그 미백 조성물 |
| CN104257515B (zh) * | 2010-10-22 | 2017-05-03 | 新钰生技股份有限公司 | 具有抑制黑色素生成的甘胺酸衍生物及使用其的美白组成物 |
| UA115431C2 (uk) * | 2011-10-11 | 2017-11-10 | Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" | Застосування глутарилгістаміну для лікування захворювань дихальних шляхів |
| CN103382179A (zh) * | 2013-06-05 | 2013-11-06 | 四川百利药业有限责任公司 | 英加韦林的多晶型物及其制备方法 |
| RU2628800C2 (ru) * | 2014-03-12 | 2017-08-22 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Амидные соединения, способы получения, применение в качестве средств для лечения и профилактики заболеваний, вызываемых рнк-содержащими вирусами |
| WO2020064832A1 (en) * | 2018-09-25 | 2020-04-02 | Myelo Therapeutics Gmbh | Imidazolyl ethanamide pentandioic acid for use in therapy of symptoms related to exposure to lethal radiation |
| RU2726119C1 (ru) * | 2019-11-22 | 2020-07-09 | Общество С Ограниченной Ответственностью "Валента - Интеллект" | Новые производные полиолов, их применение, фармацевтическая композиция на их основе |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6016926A (ja) | 1983-07-06 | 1985-01-28 | Kaneshiro Nagai | 抗腫瘍剤 |
| JPS6016934A (ja) * | 1983-07-06 | 1985-01-28 | Kaneshiro Nagai | 抗腫瘍剤 |
| US4816442A (en) * | 1986-11-07 | 1989-03-28 | Collagen Corporation | Method of inhibiting tumor growth sensitive to CIF-βtreatment |
| JPS6442430A (en) | 1987-08-11 | 1989-02-14 | Nippon Univ | Side effect remover for chemotherapeutic agent |
| US5350836A (en) * | 1989-10-12 | 1994-09-27 | Ohio University | Growth hormone antagonists |
| JPH0585942A (ja) * | 1991-02-26 | 1993-04-06 | Denki Kagaku Kogyo Kk | インターフエロン−ヒアルロン酸及び／又はその塩の結合体 |
| CA2108584C (en) * | 1992-10-27 | 1998-11-24 | James B. Doherty | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
| GB9308695D0 (en) * | 1993-04-27 | 1993-06-09 | Celltech Ltd | Peptidyl derivatives |
| IL110296A (en) * | 1993-07-16 | 1999-12-31 | Smithkline Beecham Corp | Imidazole compounds process for their preparation and pharmaceutical compositions containing them |
| WO1995011699A1 (en) | 1993-10-29 | 1995-05-04 | The Trustees Of Boston University | Physiologically stable compositions of butyric acid, and butyric acid salts and derivatives as anti-neoplastic agents |
| JP3517274B2 (ja) * | 1994-05-20 | 2004-04-12 | 株式会社ナリス化粧品 | 皮膚組成物 |
| RU2120298C1 (ru) * | 1995-11-28 | 1998-10-20 | Товарищество с ограниченной ответственностью "Верта" | Иммуностимулятор и препарат на его основе |
| FR2762315B1 (fr) * | 1997-04-22 | 1999-05-28 | Logeais Labor Jacques | Derives d'amino-acides inhibiteurs des metalloproteases de la matrice extracellulaire et de la liberation du tnf alpha |
| RU2141483C1 (ru) * | 1997-07-04 | 1999-11-20 | Небольсин Владимир Евгеньевич | Производные пептидов или их фармацевтически приемлемые соли, способ их получения, применение и фармацевтическая композиция |
| ES2318875T3 (es) | 1997-11-07 | 2009-05-01 | Mayo Foundation For Medical Education And Research | Inmunoterapias con bajas de interferon. |
| US6838436B1 (en) * | 1998-07-10 | 2005-01-04 | Osteoscreen Inc. | Inhibitors of proteasomal activity for stimulating bone growth |
| WO2000020576A2 (en) | 1998-10-02 | 2000-04-13 | The Government Of The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services, The National Institutes Of Health | Methods and compositions for inducing differentiation and apotosis in cells that overexpess the notch protein |
-
2002
- 2002-02-28 RU RU2002105392/14A patent/RU2217196C2/ru not_active IP Right Cessation
-
2003
- 2003-02-28 EA EA200401105A patent/EA007474B1/ru unknown
- 2003-02-28 IL IL16376303A patent/IL163763A0/xx unknown
- 2003-02-28 SI SI200331938T patent/SI1491206T1/sl unknown
- 2003-02-28 JP JP2003570868A patent/JP4711626B2/ja not_active Expired - Lifetime
- 2003-02-28 UA UA20040907835A patent/UA85039C2/uk unknown
- 2003-02-28 AU AU2003235538A patent/AU2003235538A1/en not_active Abandoned
- 2003-02-28 DE DE60334978T patent/DE60334978D1/de not_active Expired - Lifetime
- 2003-02-28 EP EP03743087A patent/EP1491206B9/en not_active Expired - Lifetime
- 2003-02-28 DK DK03743087.3T patent/DK1491206T3/da active
- 2003-02-28 AT AT03743087T patent/ATE488234T1/de active
- 2003-02-28 CN CN038094959A patent/CN1649612B/zh not_active Expired - Lifetime
- 2003-02-28 ES ES03743087T patent/ES2356308T3/es not_active Expired - Lifetime
- 2003-02-28 US US10/505,976 patent/US7759313B2/en not_active Expired - Lifetime
- 2003-02-28 PT PT03743087T patent/PT1491206E/pt unknown
- 2003-02-28 WO PCT/RU2003/000072 patent/WO2003072124A1/ru not_active Ceased
- 2003-02-28 HK HK06100072.5A patent/HK1079990B/zh not_active IP Right Cessation
-
2004
- 2004-08-26 IL IL163763A patent/IL163763A/en active IP Right Grant
-
2010
- 2010-11-30 IL IL209653A patent/IL209653A0/en unknown
-
2011
- 2011-02-09 CY CY20111100154T patent/CY1111265T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT1491206E (pt) | 2011-02-11 |
| IL209653A0 (en) | 2011-02-28 |
| WO2003072124A1 (en) | 2003-09-04 |
| AU2003235538A1 (en) | 2003-09-09 |
| RU2217196C2 (ru) | 2003-11-27 |
| JP2005532269A (ja) | 2005-10-27 |
| IL163763A0 (en) | 2005-12-18 |
| IL163763A (en) | 2011-12-29 |
| UA85039C2 (uk) | 2008-12-25 |
| EP1491206B9 (en) | 2011-03-09 |
| ES2356308T3 (es) | 2011-04-06 |
| HK1079990B (zh) | 2011-12-09 |
| US7759313B2 (en) | 2010-07-20 |
| US20050180953A1 (en) | 2005-08-18 |
| DK1491206T3 (da) | 2011-03-14 |
| CN1649612A (zh) | 2005-08-03 |
| HK1079990A1 (en) | 2006-04-21 |
| EP1491206B1 (en) | 2010-11-17 |
| JP4711626B2 (ja) | 2011-06-29 |
| EP1491206A4 (en) | 2006-01-11 |
| EP1491206A1 (en) | 2004-12-29 |
| CN1649612B (zh) | 2011-04-06 |
| CY1111265T1 (el) | 2015-08-05 |
| SI1491206T1 (sl) | 2011-03-31 |
| EA007474B1 (ru) | 2006-10-27 |
| EA200401105A1 (ru) | 2004-12-30 |
| ATE488234T1 (de) | 2010-12-15 |
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