CN1600310A - 一种利拉萘酯凝胶组合物及其制备方法 - Google Patents
一种利拉萘酯凝胶组合物及其制备方法 Download PDFInfo
- Publication number
- CN1600310A CN1600310A CN 200410000310 CN200410000310A CN1600310A CN 1600310 A CN1600310 A CN 1600310A CN 200410000310 CN200410000310 CN 200410000310 CN 200410000310 A CN200410000310 A CN 200410000310A CN 1600310 A CN1600310 A CN 1600310A
- Authority
- CN
- China
- Prior art keywords
- liranaftate
- weight
- gel
- preferred
- gel combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- VPHPQNGOVQYUMG-UHFFFAOYSA-N Liranaftate Chemical compound COC1=CC=CC(N(C)C(=S)OC=2C=C3CCCCC3=CC=2)=N1 VPHPQNGOVQYUMG-UHFFFAOYSA-N 0.000 title claims abstract description 35
- 229950010148 liranaftate Drugs 0.000 title claims abstract description 35
- 238000002360 preparation method Methods 0.000 title claims description 20
- 108010010803 Gelatin Proteins 0.000 title claims description 3
- 229920000159 gelatin Polymers 0.000 title claims description 3
- 239000008273 gelatin Substances 0.000 title claims description 3
- 235000019322 gelatine Nutrition 0.000 title claims description 3
- 235000011852 gelatine desserts Nutrition 0.000 title claims description 3
- 239000000203 mixture Substances 0.000 claims abstract description 13
- 239000000080 wetting agent Substances 0.000 claims abstract description 10
- 239000006184 cosolvent Substances 0.000 claims abstract description 9
- 239000000499 gel Substances 0.000 claims description 31
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 8
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 4
- 239000004141 Sodium laurylsulphate Substances 0.000 claims description 4
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 claims description 4
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 claims description 4
- GYCKQBWUSACYIF-UHFFFAOYSA-N o-hydroxybenzoic acid ethyl ester Natural products CCOC(=O)C1=CC=CC=C1O GYCKQBWUSACYIF-UHFFFAOYSA-N 0.000 claims description 4
- 229960000502 poloxamer Drugs 0.000 claims description 4
- 229920001983 poloxamer Polymers 0.000 claims description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- 229960001631 carbomer Drugs 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 claims description 2
- 229920000136 polysorbate Polymers 0.000 claims description 2
- 229950008882 polysorbate Drugs 0.000 claims description 2
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 2
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 claims description 2
- 239000004094 surface-active agent Substances 0.000 claims description 2
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 claims 1
- 230000002421 anti-septic effect Effects 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 abstract description 7
- 238000000034 method Methods 0.000 abstract description 3
- 238000009792 diffusion process Methods 0.000 abstract 1
- 238000007614 solvation Methods 0.000 abstract 1
- 239000000758 substrate Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 238000003756 stirring Methods 0.000 description 7
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 6
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 5
- 229940082484 carbomer-934 Drugs 0.000 description 5
- 239000007864 aqueous solution Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 206010017533 Fungal infection Diseases 0.000 description 3
- 208000031888 Mycoses Diseases 0.000 description 3
- 208000002474 Tinea Diseases 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000725 suspension Substances 0.000 description 3
- 241000251774 Squalus Species 0.000 description 2
- 241000130764 Tinea Species 0.000 description 2
- 201000010618 Tinea cruris Diseases 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- -1 polyoxyethylene Polymers 0.000 description 2
- 239000001194 polyoxyethylene (40) stearate Substances 0.000 description 2
- 235000011185 polyoxyethylene (40) stearate Nutrition 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 201000004647 tinea pedis Diseases 0.000 description 2
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 1
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 1
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 1
- 206010012504 Dermatophytosis Diseases 0.000 description 1
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
- 229960004022 clotrimazole Drugs 0.000 description 1
- 229940111134 coxibs Drugs 0.000 description 1
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 230000001804 emulsifying effect Effects 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 238000006735 epoxidation reaction Methods 0.000 description 1
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000012622 synthetic inhibitor Substances 0.000 description 1
- 229960004880 tolnaftate Drugs 0.000 description 1
- FUSNMLFNXJSCDI-UHFFFAOYSA-N tolnaftate Chemical compound C=1C=C2C=CC=CC2=CC=1OC(=S)N(C)C1=CC=CC(C)=C1 FUSNMLFNXJSCDI-UHFFFAOYSA-N 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB200410000310XA CN100393314C (zh) | 2003-09-22 | 2004-01-07 | 一种利拉萘酯凝胶组合物及其制备方法 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN03157455 | 2003-09-22 | ||
CN03157455.6 | 2003-09-22 | ||
CNB200410000310XA CN100393314C (zh) | 2003-09-22 | 2004-01-07 | 一种利拉萘酯凝胶组合物及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1600310A true CN1600310A (zh) | 2005-03-30 |
CN100393314C CN100393314C (zh) | 2008-06-11 |
Family
ID=34679664
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB200410000310XA Expired - Lifetime CN100393314C (zh) | 2003-09-22 | 2004-01-07 | 一种利拉萘酯凝胶组合物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN100393314C (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101991858B (zh) * | 2009-08-18 | 2012-06-27 | 天津京英透皮材料科技开发有限公司 | 新型外用辅料及其制备方法 |
CN103156815A (zh) * | 2011-12-14 | 2013-06-19 | 西安泰科迈医药科技有限公司 | 一种用于白癣病的分散片制剂及其制备方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3081766B2 (ja) * | 1994-05-06 | 2000-08-28 | 東興薬品工業株式会社 | 角質貯留型抗真菌外用組成物 |
-
2004
- 2004-01-07 CN CNB200410000310XA patent/CN100393314C/zh not_active Expired - Lifetime
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101991858B (zh) * | 2009-08-18 | 2012-06-27 | 天津京英透皮材料科技开发有限公司 | 新型外用辅料及其制备方法 |
CN103156815A (zh) * | 2011-12-14 | 2013-06-19 | 西安泰科迈医药科技有限公司 | 一种用于白癣病的分散片制剂及其制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CN100393314C (zh) | 2008-06-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4139860B2 (ja) | 浸透増強および刺激減少システム | |
RU2007121474A (ru) | Фармацевтические композиции местного применения, содержащие противоугревое соединение и антибиотическое соединение | |
JP2714464B2 (ja) | 局所メトロニダゾール製剤 | |
US9415133B2 (en) | Hydrogel | |
CN1921820A (zh) | 一种治疗皮肤病炎症反应的组合物及其制备方法 | |
CN101035509A (zh) | 用于治疗用途的有机凝胶制剂 | |
US20030017207A1 (en) | Compositions and methods for treating vulvovaginitis and vaginosis | |
CN1109754A (zh) | 阿尔加特罗邦浓缩水溶液 | |
CN1407898A (zh) | 具有全身效应的新型局部雌激素孕激素组合物 | |
CN87108340A (zh) | 鼻用药配方及其制备方法 | |
CN1649603A (zh) | 包含甲硝唑的含水组合物 | |
JP2005519985A (ja) | 医薬組成物 | |
RU2587064C2 (ru) | Новая противогрибковая композиция | |
CN100341577C (zh) | 经皮吸收制剂 | |
CN1989956A (zh) | 一种阿达帕林凝胶组合物及其制备方法 | |
RU2277419C2 (ru) | Дерматологические композиции | |
CN1582161A (zh) | 包含环孢菌素的药物制剂及其用途 | |
CN1065010A (zh) | 甾类化合物的组合物 | |
CN1600310A (zh) | 一种利拉萘酯凝胶组合物及其制备方法 | |
HU196902B (en) | Process for production of locally applicable medical compositions helping wound-granulation and formation of pellicle | |
CN1210028C (zh) | 水性液体制剂 | |
CN1476898A (zh) | 口服给药后能延长释放的治疗感冒复方骨架片 | |
JPH09176014A (ja) | 抗真菌性外用組成物 | |
CN109966241A (zh) | 一种促渗组合物在外用制剂经皮促渗中的应用 | |
CN1092050C (zh) | 混合型聚维酮碘消毒剂及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Beijing D-Venture Pharmaceutical Technology Corp. Assignor: Beijing D-Venturepharm Technology Development Co.,Ltd. Contract fulfillment period: 2008.10.8 to 2013.10.8 Contract record no.: 2008990001349 Denomination of invention: Combination of Liranaftate gelatin and preparation method Granted publication date: 20080611 License type: Exclusive license Record date: 20081203 |
|
LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2008.10.8 TO 2013.10.8; CHANGE OF CONTRACT Name of requester: BEIJING DEZHONG WANQUAN PHARMACEUTICAL TECHNOLOGY Effective date: 20081203 |
|
ASS | Succession or assignment of patent right |
Owner name: JIANGSU AVENTIS PHARMA. CO., LTD. Free format text: FORMER OWNER: DEZHONG WANQUAN PHARMACEUTICALS TECH. DEV. CO., LTD., BEIJING Effective date: 20120530 |
|
C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 100089 HAIDIAN, BEIJING TO: 225300 TAIZHOU, JIANGSU PROVINCE |
|
TR01 | Transfer of patent right |
Effective date of registration: 20120530 Address after: 225300 Taizhou City, Jiangsu Province medicine City Avenue, No. 1 Patentee after: JIANGSU AVENTIS PHARMACEUTICAL CO.,LTD. Address before: 100089, Wanquan mansion, three Jin Zhuang, Haidian District, Beijing, Sijiqing Patentee before: Beijing D-Venturepharm Technology Development Co.,Ltd. |
|
C56 | Change in the name or address of the patentee | ||
CP01 | Change in the name or title of a patent holder |
Address after: 225300 Taizhou City, Jiangsu Province medicine City Avenue, No. 1 Patentee after: WANQUAN WANTE PHARMACEUTICAL JIANGSU Co.,Ltd. Address before: 225300 Taizhou City, Jiangsu Province medicine City Avenue, No. 1 Patentee before: JIANGSU AVENTIS PHARMACEUTICAL CO.,LTD. |
|
CX01 | Expiry of patent term |
Granted publication date: 20080611 |
|
CX01 | Expiry of patent term |