CN1589877A - Ready prepared Chinese medicine for treating angeitis and preparation process - Google Patents
Ready prepared Chinese medicine for treating angeitis and preparation process Download PDFInfo
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- CN1589877A CN1589877A CN 200410010814 CN200410010814A CN1589877A CN 1589877 A CN1589877 A CN 1589877A CN 200410010814 CN200410010814 CN 200410010814 CN 200410010814 A CN200410010814 A CN 200410010814A CN 1589877 A CN1589877 A CN 1589877A
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- chinese patent
- patent medicine
- radix
- angelicae sinensis
- ramulus cinnamomi
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Abstract
A Chinese patent medicine for treating vasculitis, periomethritis and menalgia is prepared from 6 Chinese-medicinal materials including Chinese angelica root, white peony root, cinammon twigs, liquorice root, etc. Its preparing process is also disclosed.
Description
Technical field
The invention belongs to medical technical field.
Background technology
At present, treat vasculitic Chinese patent medicine, have the function that heat-clearing and toxic substances removing is invigorated blood circulation mostly, can be used for the disease of pyretic toxicity stasis of blood resistance, but be not suitable for the vasculitis of pathogenic stasis block, clinical needs have the Chinese patent medicine of warm promoting blood circulation.
Summary of the invention
Technical problem to be solved by this invention is:
A kind of a kind of treatment vasculitic Chinese patent medicine and the preparation process good to the pathogenic stasis block therapeutic effect are provided.
Ingredient of the present invention and ratio range (weight ratio) are:
Radix Angelicae Sinensis 10-30
Radix Paeoniae Alba 10-30
Ramulus Cinnamomi 10-30
Caulis Clematidis Armandii 5-15
Radix Glycyrrhizae 5-15
Fructus Jujubae 5-15
Ingredient optimum ratio scope of the present invention (weight ratio) is:
Radix Angelicae Sinensis 10-20
Radix Paeoniae Alba 10-20
Ramulus Cinnamomi 10-20
Caulis Clematidis Armandii 5-15
Radix Glycyrrhizae 5-10
Fructus Jujubae 5-15
The best proportioning of ingredient of the present invention is:
Radix Angelicae Sinensis 15
The Radix Paeoniae Alba 15
Ramulus Cinnamomi 15
Caulis Clematidis Armandii 9
Radix Glycyrrhizae 6
Fructus Jujubae 9
Medicine reparation technology of the present invention may further comprise the steps:
1, by weight the 5--15 times of pure water that takes by weighing Radix Angelicae Sinensis coarse powder, Ramulus Cinnamomi coarse powder adding medical material total amount respectively, steam distillation 3-6 hour or adopt supercritical extraction, extract volatile oil, and doubly measure cyclodextrin with the 2-30 of volatile oil and carry out enclose, lyophilization or 35-50 ℃ is dried to dried, standby.
2, with the said extracted Radix Angelicae Sinensis, Ramulus Cinnamomi extracts the medicinal residues behind the volatile oil, add the Radix Paeoniae Alba, Caulis Clematidis Armandii, Radix Glycyrrhizae, Fructus Jujubae, extracting in water 2-4 time, the 3-15 of (comprising the Aromatic water of putting forward oily usefulness) that each amount of water is the raw medicinal herbs total amount doubly, extraction time was respectively 0.2-5 hour, filter, merging filtrate, left standstill 18-36 hour, get supernatant 30--80 ℃ and be evaporated to the concentrated solution that relative density is 1.0-2.0 (20 ℃), add 55-99.5% ethanol and carry out alcohol and handle, processing 50-70% when containing alcohol, left standstill 18--36 hour, filter, filtrate 30-80 ℃ decompression recycling ethanol, and to be concentrated into relative density be 1.0-1.4 (20 ℃), be dried to or adopt marumerization to granulate, promptly.
3, the described extracting method of step 2 can adopt the alcohol extraction method: get the medicinal residues after Radix Angelicae Sinensis, Ramulus Cinnamomi extract volatile oil, add the Radix Paeoniae Alba, Caulis Clematidis Armandii, Radix Glycyrrhizae, Fructus Jujubae, the ethanol extraction of adding 30-60% 2-4 time, the 3-15 that each adding ethanol is the raw medicinal herbs amount doubly, extraction time was respectively 0.2-5 hour, filter, merging filtrate, left standstill 18-36 hour, get supernatant and reclaim ethanol in 30-80 ℃, and to be evaporated to relative density be 1.0-1.4 (20 ℃), is dried to or adopts marumerization to granulate, promptly.
4, the dry extract of getting step 2 or step 3 gained is pulverized, with the volatile oil clathrate compound mix homogeneously, add any or multiple blended medicinal diluent, base unit weight is 0.1-1.5 a times of mixed powder weight, mix thoroughly, be ground into fine powder or make the granule of diameter 0.2-3mm, make various pharmaceutical preparatioies after making various pharmaceutical preparatioies or coating then.
5, the described inclusion method of step 1 comprises saturated water solution method, supercritical ultrasonics technology, polishing, spray drying and lyophilization etc.
6, the described drying of step 2 comprises drying under reduced pressure, spray drying and lyophilization.
7, the described pharmaceutical diluents of step 3 comprises starch, dextrin, Icing Sugar, mannitol.
8, the described pharmaceutical preparation of step 3 can be made into said any dosage form on the pharmaceutics, comprises tablet, capsule, granule, pill, powder, membrane, microcapsule, drop pill, aerosol, unguentum, syrup, oral agents, mixture.
The invention has the beneficial effects as follows:
To obvious, also effective in cure to scapulohumeral periarthritis, dysmenorrhes simultaneously by the vasculitis patient treatment effect of pathogenic stasis block initiation, realized suitability for industrialized production, guaranteed the quality of medicine.
The specific embodiment:
Embodiment 1:
It is as follows to prepare Radix Angelicae Sinensis cold limbs pharmaceutical capsules concrete steps of the present invention:
Take by weighing Radix Angelicae Sinensis coarse powder 1.5kg, Ramulus Cinnamomi coarse powder 1.5kg respectively, add 10 times of pure water of medical material total amount, steam distillation 5 hours extracts volatile oil, and carries out enclose with 10 times of amount cyclodextrin of volatile oil, and lyophilization or 35-50 ℃ is dried to dried, standby.
With the said extracted Radix Angelicae Sinensis, Ramulus Cinnamomi extracts the medicinal residues behind the volatile oil, add Radix Paeoniae Alba 1.5kg, Caulis Clematidis Armandii 0.9kg, Radix Glycyrrhizae 0.6kg, Fructus Jujubae 0.9kg, extracting in water 2 times, for the first time amount of water be the raw medicinal herbs total amount (comprising the Aromatic water of putting forward oily usefulness) 8-10 doubly, extraction time was respectively 1 hour, for the second time amount of water be the raw medicinal herbs total amount 5-8 doubly, extraction time was respectively 0.5 hour, filtered merging filtrate, left standstill 24 hours, get supernatant 30-80 ℃ and be evaporated to the concentrated solution that relative density is 1.1-1.2 (20 ℃), add 85-95% ethanol and carry out alcohol and handle, processing is when containing alcohol 60%, left standstill 24 hours, filter, filtrate 30-80 ℃ decompression recycling ethanol, and be concentrated into the thick paste that relative density is 1.2-1.3 (20 ℃), be dried to dried, promptly.
Get extract powder, volatile oil clathrate compound mix homogeneously, add the dextrin of the 10-40% of mixed powder total amount, mix thoroughly, be ground into fine powder or make the granule of diameter 0.2-3mm, promptly encapsulated.
Embodiment 2:
It is as follows to prepare Radix Angelicae Sinensis cold limbs pharmaceutical capsules concrete steps of the present invention:
Technology is identical with embodiment 1 before producing extract powder, just at the dextrin of the 10-40% that adds the mixed powder total amount, is processed into tablet after mixing thoroughly.
Claims (8)
1, the vasculitic Chinese patent medicine of a kind of treatment: ingredient and ratio range (weight ratio) are:
Radix Angelicae Sinensis 10---30
The Radix Paeoniae Alba 10---30
Ramulus Cinnamomi 10---30
Caulis Clematidis Armandii 5---15
Radix Glycyrrhizae 5---15
Fructus Jujubae 5---15
2, the vasculitic Chinese patent medicine of a kind of treatment according to claim 1, its ingredient optimum ratio scope (weight ratio) is:
Radix Angelicae Sinensis 10---20
The Radix Paeoniae Alba 10---20
Ramulus Cinnamomi 10---20
Caulis Clematidis Armandii 5---15
Radix Glycyrrhizae 5---10
Fructus Jujubae 5---15
3, the vasculitic Chinese patent medicine of a kind of treatment according to claim 1, the best proportioning of its ingredient is:
Radix Angelicae Sinensis 15
The Radix Paeoniae Alba 15
Ramulus Cinnamomi 15
Caulis Clematidis Armandii 9
Radix Glycyrrhizae 6
Fructus Jujubae 9
4, the vasculitic Chinese patent medicine preparation technology of a kind of treatment, its preparation process is:
A, by weight take by weighing the Radix Angelicae Sinensis coarse powder respectively, the Ramulus Cinnamomi coarse powder adds 5 of medical material total amount---15 times of pure water, steam distillation 3---6 hours or employing supercritical extraction, extract volatile oil, and with 2 of volatile oil---30 times of amount cyclodextrin carry out enclose, lyophilization or 35---50 ℃ are dried to dried, standby;
B, with the said extracted Radix Angelicae Sinensis, Ramulus Cinnamomi extracts the medicinal residues behind the volatile oil, add the Radix Paeoniae Alba, Caulis Clematidis Armandii, Radix Glycyrrhizae, Fructus Jujubae, extracting in water 2---4 times, 3 of (the comprising the Aromatic water of putting forward oily usefulness) that each amount of water is the raw medicinal herbs total amount---15 times, extraction time is respectively 0.2---and 5 hours, filter, merging filtrate, leave standstill 18---36 hours,---80 ℃ are evaporated to relative density is 1.0---concentrated solution of 2.0 (20 ℃) of getting supernatant 30 adds 55---and 99.5% ethanol carries out alcohol to be handled, and processing is when containing alcohol 50---and 70%, leave standstill 18---36 hours, filter, filtrate 30---80 ℃ of decompression recycling ethanols, and to be concentrated into relative density be 1.0---1.4 (20 ℃), be dried to dry extract or adopt marumerization to granulate, promptly;
C, dry extract are pulverized, with the volatile oil clathrate compound mix homogeneously, add any or multiple blended medicinal diluent, base unit weight is 0.1 of a mixed powder weight---1.5 times, mix thoroughly, be ground into fine powder or make diameter 0.2---the granule of 3mm, make various pharmaceutical preparatioies after making various pharmaceutical preparatioies or coating then.
5, the vasculitic Chinese patent medicine preparation technology of a kind of treatment according to claim 4, its preparation process is:
Inclusion method comprises saturated water solution method, supercritical ultrasonics technology, polishing, spray drying and lyophilization.
6, the vasculitic Chinese patent medicine preparation technology of a kind of treatment according to claim 4, its preparation process is: comprise tablet, capsule, granule, pill, powder, membrane, microcapsule, drop pill, aerosol, unguentum, syrup, oral agents, mixture.
7, the vasculitic Chinese patent medicine preparation technology of a kind of treatment according to claim 4, its preparation process is:
Extracting method can adopt the alcohol extraction method: get the medicinal residues after Radix Angelicae Sinensis, Ramulus Cinnamomi extract volatile oil, add the Radix Paeoniae Alba, Caulis Clematidis Armandii, Radix Glycyrrhizae, Fructus Jujubae, add 30---ethanol extractions 2 of 60%---4 times, each adding ethanol is 3 of raw medicinal herbs amount---15 times, extraction time is respectively 0.2---and 5 hours, filter, merging filtrate, leave standstill 18---36 hours, get supernatant in 30---80 ℃ are reclaimed ethanol, and to be evaporated to relative density be 1.0---1.4 (20 ℃) are dried to or adopt marumerization to granulate, promptly.
8, according to claim 4, the vasculitic Chinese patent medicine preparation technology of 7 described a kind of treatments, its preparation process is:
Pharmaceutical diluents comprises starch, dextrin, Icing Sugar, mannitol.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN 200410010814 CN1270740C (en) | 2004-04-23 | 2004-04-23 | Ready prepared Chinese medicine for treating angeitis and preparation process |
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CN 200410010814 CN1270740C (en) | 2004-04-23 | 2004-04-23 | Ready prepared Chinese medicine for treating angeitis and preparation process |
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CN1589877A true CN1589877A (en) | 2005-03-09 |
CN1270740C CN1270740C (en) | 2006-08-23 |
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CN 200410010814 Expired - Fee Related CN1270740C (en) | 2004-04-23 | 2004-04-23 | Ready prepared Chinese medicine for treating angeitis and preparation process |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104258235A (en) * | 2014-10-10 | 2015-01-07 | 高瑛 | Traditional Chinese medicine for treating cold stasis type vasculitis and preparation method thereof |
CN104622970A (en) * | 2015-03-07 | 2015-05-20 | 陈获吉 | Drug for treating ulcers and preparation method of drug |
CN105168611A (en) * | 2015-08-31 | 2015-12-23 | 霍传英 | Medicine for treating thromboangiitis obliterans and preparation method |
CN108837132A (en) * | 2018-09-06 | 2018-11-20 | 河南中医药大学 | A kind of essential oil of traditional Chinese medicine for treating thromboangitis obliterans |
CN111557991A (en) * | 2020-06-01 | 2020-08-21 | 陶文革 | Formula for warming uterus and activating blood and preparation method thereof |
-
2004
- 2004-04-23 CN CN 200410010814 patent/CN1270740C/en not_active Expired - Fee Related
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104258235A (en) * | 2014-10-10 | 2015-01-07 | 高瑛 | Traditional Chinese medicine for treating cold stasis type vasculitis and preparation method thereof |
CN104622970A (en) * | 2015-03-07 | 2015-05-20 | 陈获吉 | Drug for treating ulcers and preparation method of drug |
CN105168611A (en) * | 2015-08-31 | 2015-12-23 | 霍传英 | Medicine for treating thromboangiitis obliterans and preparation method |
CN108837132A (en) * | 2018-09-06 | 2018-11-20 | 河南中医药大学 | A kind of essential oil of traditional Chinese medicine for treating thromboangitis obliterans |
CN111557991A (en) * | 2020-06-01 | 2020-08-21 | 陶文革 | Formula for warming uterus and activating blood and preparation method thereof |
Also Published As
Publication number | Publication date |
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CN1270740C (en) | 2006-08-23 |
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