CN1270740C

CN1270740C - Ready prepared Chinese medicine for treating angeitis and preparation process

Info

Publication number: CN1270740C
Application number: CN 200410010814
Authority: CN
Inventors: 窦昌贵; 黄罗生; 黄芳
Original assignee: JILIN NORTHEAST ASIA PHARMACEUTICAL Co Ltd
Current assignee: JILIN NORTHEAST ASIA PHARMACEUTICAL Co Ltd
Priority date: 2004-04-23
Filing date: 2004-04-23
Publication date: 2006-08-23
Anticipated expiration: 2024-04-23
Also published as: CN1589877A

Abstract

The present invention relates to a traditional Chinese medicine for treating angitis and a preparation technology, which belongs to the technical field of medicines. The traditional Chinese medicine has the medicine ingredients and proportion ranges: 10 to 30 portions of angelica, 10 to 30 portions of white peony roots, 10 to 30 portions of cassia twigs, 5 to 15 portions of armand clematis, 5 to 15 portions of liquorice and 5 to 15 portions of Chinese dates. The preparation technology comprises: taking the angelica, the white peony roots and the cassia twigs; extracting volatile oil by a distillation method; adding dextrin volatile oil solid powder; decocting the white peony roots, the armand clematis, the liquorice and the Chinese dates; concentrating the decoction liquid into dense concrete paste; uniformly mixing the solid powder and the concrete paste to obtain concrete paste powder for preparing the medicine. The present invention has the advantages that the medicine has obvious therapeutic effect on angitis patients caused by cold stasis retardation, and simultaneously has therapeutic effect on humeral periarthritis and woman dysmenorrhea. The present invention realizes industrial production and ensures quality.

Description

Vasculitic Chinese patent medicine of a kind of treatment and preparation process

Technical field

The invention belongs to medical technical field.

Background technology

At present, treat vasculitic Chinese patent medicine, have the function that heat-clearing and toxic substances removing is invigorated blood circulation mostly, can be used for the disease of pyretic toxicity stasis of blood resistance, but be not suitable for the vasculitis of pathogenic stasis block, clinical needs have the Chinese patent medicine of warm promoting blood circulation.

Summary of the invention

Technical problem to be solved by this invention is:

A kind of a kind of treatment vasculitic Chinese patent medicine and the preparation process good to the pathogenic stasis block therapeutic effect are provided.

Ingredient of the present invention and ratio range (weight ratio) are:

Radix Angelicae Sinensis 10---30

The Radix Paeoniae Alba 10---30

Ramulus Cinnamomi 10---30

Caulis Clematidis Armandii 5---15

Radix Glycyrrhizae 5---15

Fructus Jujubae 5---15

Ingredient optimum ratio scope of the present invention (weight ratio) is:

Radix Angelicae Sinensis 10---20

The Radix Paeoniae Alba 10---20

Ramulus Cinnamomi 10---20

Caulis Clematidis Armandii 5---15

Radix Glycyrrhizae 5---10

Fructus Jujubae 5---15

The best proportioning of ingredient of the present invention is:

Radix Angelicae Sinensis 15

The Radix Paeoniae Alba 15

Ramulus Cinnamomi 15

Caulis Clematidis Armandii 9

Radix Glycyrrhizae 6

Fructus Jujubae 9

Medicine reparation technology of the present invention may further comprise the steps:

1, by weight taking by weighing 5 of Radix Angelicae Sinensis coarse powder, Ramulus Cinnamomi coarse powder adding medical material total amount---15 times of pure water respectively, steam distillation 3---6 hours or employing supercritical extraction, extract volatile oil, and with 2 of volatile oil---30 times of amount cyclodextrin carry out enclose, lyophilization or 35---50 ℃ are dried to dried, standby.

2, with the said extracted Radix Angelicae Sinensis, Ramulus Cinnamomi extracts the medicinal residues behind the volatile oil, add the Radix Paeoniae Alba, Caulis Clematidis Armandii, Radix Glycyrrhizae, Fructus Jujubae, extracting in water 2---4 times, 3 of (the comprising the Aromatic water of putting forward oily usefulness) that each amount of water is the raw medicinal herbs total amount---15 times, extraction time is respectively 0.2---and 5 hours, filter, merging filtrate, leave standstill 18---36 hours,---80 ℃ are evaporated to relative density is 1.0---concentrated solution of 2.0 (20 ℃) of getting supernatant 30 adds 55---and 99.5% ethanol carries out alcohol to be handled, and processing is when containing alcohol 50---and 70%, leave standstill 18---36 hours, filter, filtrate 30---80 ℃ of decompression recycling ethanols, and to be concentrated into relative density be 1.0---1.4 (20 ℃), be dried to or adopt marumerization to granulate, promptly.

3, the described extracting method of step 2 can adopt the alcohol extraction method: get the medicinal residues after Radix Angelicae Sinensis, Ramulus Cinnamomi extract volatile oil, add the Radix Paeoniae Alba, Caulis Clematidis Armandii, Radix Glycyrrhizae, Fructus Jujubae, add 30---ethanol extractions 2 of 60%---4 times, each adding ethanol is 3 of raw medicinal herbs amount---15 times, extraction time is respectively 0.2---and 5 hours, filter, merging filtrate, leave standstill 18---36 hours, get supernatant in 30---80 ℃ are reclaimed ethanol, and to be evaporated to relative density be 1.0---1.4 (20 ℃) are dried to or adopt marumerization to granulate, promptly.

4, the dry extract of getting step 2 or step 3 gained is pulverized, with the volatile oil clathrate compound mix homogeneously, add any or multiple blended medicinal diluent, base unit weight is 0.1 of a mixed powder weight---1.5 times, mix thoroughly, be ground into fine powder or make diameter 0.2---the granule of 3mm, make various pharmaceutical preparatioies after making various pharmaceutical preparatioies or coating then.

5, the described inclusion method of step 1 comprises saturated water solution method, supercritical ultrasonics technology, polishing, spray drying and lyophilization etc.

6, the described drying of step 2 comprises drying under reduced pressure, spray drying and lyophilization.

7, the described pharmaceutical diluents of step 3 comprises starch, dextrin, Icing Sugar, mannitol.

8, the described pharmaceutical preparation of step 3 can be made into said any dosage form on the pharmaceutics, comprises tablet, capsule, granule, pill, powder, membrane, microcapsule, drop pill, aerosol, unguentum, syrup, oral agents, mixture.

The invention has the beneficial effects as follows:

To obvious, also effective in cure to scapulohumeral periarthritis, dysmenorrhes simultaneously by the vasculitis patient treatment effect of pathogenic stasis block initiation, realized suitability for industrialized production, guaranteed the quality of medicine.

The specific embodiment:

Embodiment 1:

It is as follows to prepare Radix Angelicae Sinensis cold limbs pharmaceutical capsules concrete steps of the present invention:

Take by weighing Radix Angelicae Sinensis coarse powder 1.5kg, Ramulus Cinnamomi coarse powder 1.5kg respectively, add 10 times of pure water of medical material total amount, steam distillation 5 hours extracts volatile oil, and carries out enclose, lyophilization or 35 with 10 times of amount cyclodextrin of volatile oil---and 50 ℃ are dried to dried, standby.

With the said extracted Radix Angelicae Sinensis, Ramulus Cinnamomi extracts the medicinal residues behind the volatile oil, add Radix Paeoniae Alba 1.5kg, Caulis Clematidis Armandii 0.9kg, Radix Glycyrrhizae 0.6kg, Fructus Jujubae 0.9kg, extracting in water 2 times, for the first time amount of water be the raw medicinal herbs total amount (comprising the Aromatic water of putting forward oily usefulness) 8---10 times, extraction time was respectively 1 hour, amount of water is 5 of a raw medicinal herbs total amount for the second time---8 times, extraction time was respectively 0.5 hour, filtered merging filtrate, left standstill 24 hours,---80 ℃ are evaporated to relative density is 1.1---concentrated solution of 1.2 (20 ℃) of getting supernatant 30 adds 85---and 95% ethanol carries out alcohol to be handled, and processing is when containing alcohol 60%, left standstill 24 hours, filter, filtrate 30---80 ℃ of decompression recycling ethanols, and to be concentrated into relative density be 1.2---the thick paste of 1.3 (20 ℃), be dried to dried, promptly.

Get extract powder, volatile oil clathrate compound mix homogeneously, add 10 of mixed powder total amount---40% dextrin, mix thoroughly, be ground into fine powder or make diameter 0.2---the granule of 3mm, promptly encapsulated.

Embodiment 2:

Technology is identical with embodiment 1 before producing extract powder, and just 10 of mixed powder total amount---40% dextrin is processed into tablet after mixing thoroughly adding.

Claims

1, the vasculitic Chinese patent medicine of a kind of treatment, ingredient and weight proportion scope are:

Radix Angelicae Sinensis 10---30,

The Radix Paeoniae Alba 10---30, Ramulus Cinnamomi 10---30, Caulis Clematidis Armandii 5---15, Radix Glycyrrhizae 5---15, Fructus Jujubae 5---15.

2, the vasculitic Chinese patent medicine of a kind of treatment according to claim 1, its ingredient and weight proportion scope are: Radix Angelicae Sinensis 10---20, the Radix Paeoniae Alba 10---20, Ramulus Cinnamomi 10---20, Caulis Clematidis Armandii 5---15, Radix Glycyrrhizae 5---10, Fructus Jujubae 5---15.

3, the vasculitic Chinese patent medicine of a kind of treatment according to claim 1, the weight proportion of its ingredient is: Radix Angelicae Sinensis 15, the Radix Paeoniae Alba 15, Ramulus Cinnamomi 15, Caulis Clematidis Armandii 9, Radix Glycyrrhizae 6, Fructus Jujubae 9.