CN1575339A - 用于生产异源性蛋白的、衍生自正链rna病毒基因组的复制子 - Google Patents

用于生产异源性蛋白的、衍生自正链rna病毒基因组的复制子 Download PDF

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CN1575339A
CN1575339A CNA028104889A CN02810488A CN1575339A CN 1575339 A CN1575339 A CN 1575339A CN A028104889 A CNA028104889 A CN A028104889A CN 02810488 A CN02810488 A CN 02810488A CN 1575339 A CN1575339 A CN 1575339A
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rna
protein
virus
self
molecule
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尼古拉斯·埃斯克瑞欧
西尔维·范－德尔－韦夫
马尔科·维纽齐
西尔维·热尔博
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Institut Pasteur
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Institut Pasteur
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/32011—Picornaviridae
    • C12N2770/32211—Cardiovirus, e.g. encephalomyocarditis virus
    • C12N2770/32241—Use of virus, viral particle or viral elements as a vector
    • C12N2770/32243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2820/00—Vectors comprising a special origin of replication system
    • C12N2820/60—Vectors comprising a special origin of replication system from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

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  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CNA028104889A 2001-05-23 2002-05-23 用于生产异源性蛋白的、衍生自正链rna病毒基因组的复制子 Pending CN1575339A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29251501P 2001-05-23 2001-05-23
US60/292,515 2001-05-23

Publications (1)

Publication Number Publication Date
CN1575339A true CN1575339A (zh) 2005-02-02

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ID=23124993

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CNA028104889A Pending CN1575339A (zh) 2001-05-23 2002-05-23 用于生产异源性蛋白的、衍生自正链rna病毒基因组的复制子

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US (2) US20030077251A1 (enExample)
EP (1) EP1390517A2 (enExample)
JP (1) JP2005508610A (enExample)
KR (1) KR20040007567A (enExample)
CN (1) CN1575339A (enExample)
AU (1) AU2002339603A1 (enExample)
CA (1) CA2443258A1 (enExample)
WO (1) WO2002095023A2 (enExample)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103764121A (zh) * 2011-07-06 2014-04-30 诺华股份有限公司 用于递送rna分子的具有有用n:p比的脂质体
CN114231562A (zh) * 2021-12-15 2022-03-25 中国科学院武汉病毒研究所 一种表达荧光素酶基因的淋巴脉络丛脑膜炎病毒及其构建方法和应用
WO2023109975A3 (zh) * 2021-12-17 2023-08-10 华南理工大学 提高基因表达的rna复制子及其应用
WO2023221938A1 (zh) * 2022-05-16 2023-11-23 上海行深生物科技有限公司 蛋白包裹自复制rna及其制备方法

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA05012542A (es) 2003-06-05 2006-02-08 Wyeth Corp Composiciones inmunogenicas que comprenden vectores de replicon del virus de la encefalitis equina venezolana y antigenos de la proteina del paramixovirus.
KR100788894B1 (ko) 2005-12-09 2007-12-27 한국전자통신연구원 확대된 서비스 영역을 제공하는 직교 주파수 분할 다중방식의 무선 랜 송수신 시스템 및 그 방법
WO2008103755A1 (en) * 2007-02-20 2008-08-28 Mayo Foundation For Medical Education And Research Treating cancer with viral nucleic acid
US9909192B2 (en) * 2007-06-01 2018-03-06 Universidad De Barcelona Control for virus detection assays based on reverse-transcription polymerase chain reaction
EP2130912A1 (en) * 2008-06-04 2009-12-09 Institut für Viruskrankeiten und Immunprophylaxe Pestivirus replicons providing an RNA-based viral vector system
ES2543222T3 (es) * 2008-09-24 2015-08-17 Ribomic Inc. Aptámero para NGF y uso del mismo
PL2590676T3 (pl) 2010-07-06 2017-02-28 Glaxosmithkline Biologicals Sa Wirionopodobne cząstki dostarczające dla autoreplikujących się cząsteczek rna
EP2591114B1 (en) 2010-07-06 2016-06-08 GlaxoSmithKline Biologicals SA Immunisation of large mammals with low doses of rna
DK3243526T3 (da) 2010-07-06 2020-02-17 Glaxosmithkline Biologicals Sa Levering af rna til at udløse flere immunsignalveje
US9770463B2 (en) 2010-07-06 2017-09-26 Glaxosmithkline Biologicals Sa Delivery of RNA to different cell types
BR112013000244A2 (pt) 2010-07-06 2016-05-17 Novartis Ag lipossomas com lipídeos apresentando pka vantajoso para administração de rna
MX341989B (es) 2010-08-31 2016-09-09 Novartis Ag * Liposomas pequeños para el suministro de arn que codifica el inmunogeno.
RS63315B1 (sr) 2010-08-31 2022-07-29 Glaxosmithkline Biologicals Sa Pegilovani lipozomi za isporuku rnk koja kodira imunogen
CA2814386C (en) 2010-10-11 2019-08-20 Novartis Ag Antigen delivery platforms
CA3198966A1 (en) 2011-06-08 2012-12-13 Translate Bio, Inc. Cleavable lipids
US20140206753A1 (en) 2011-06-08 2014-07-24 Shire Human Genetic Therapies, Inc. Lipid nanoparticle compositions and methods for mrna delivery
CA2840989A1 (en) 2011-07-06 2013-01-10 Novartis Ag Immunogenic combination compositions and uses thereof
KR20230019450A (ko) * 2020-05-29 2023-02-08 온코루스, 인크. 캡슐화된 rna 레플리콘 및 사용 방법
WO2024225374A1 (ja) * 2023-04-25 2024-10-31 慎治 小笠原 インフルエンザウイルスのＲｄＲｐによるｖＲＮＡの転写及び／又は複製を制御する方法、並びにその利用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9125896D0 (en) * 1991-12-05 1992-02-05 Almond Jeffrey W Bicistronic viruses
WO1994029472A2 (en) * 1993-06-03 1994-12-22 Institut Pasteur Mengovirus as a vector for expression of foreign polypeptides
US5811407A (en) * 1997-02-19 1998-09-22 The University Of North Carolina At Chapel Hill System for the in vivo delivery and expression of heterologous genes in the bone marrow

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103764121A (zh) * 2011-07-06 2014-04-30 诺华股份有限公司 用于递送rna分子的具有有用n:p比的脂质体
CN114231562A (zh) * 2021-12-15 2022-03-25 中国科学院武汉病毒研究所 一种表达荧光素酶基因的淋巴脉络丛脑膜炎病毒及其构建方法和应用
WO2023109975A3 (zh) * 2021-12-17 2023-08-10 华南理工大学 提高基因表达的rna复制子及其应用
WO2023221938A1 (zh) * 2022-05-16 2023-11-23 上海行深生物科技有限公司 蛋白包裹自复制rna及其制备方法

Also Published As

Publication number Publication date
KR20040007567A (ko) 2004-01-24
WO2002095023A2 (en) 2002-11-28
AU2002339603A1 (en) 2002-12-03
JP2005508610A (ja) 2005-04-07
US20050118566A1 (en) 2005-06-02
WO2002095023A3 (en) 2003-05-08
US20030077251A1 (en) 2003-04-24
CA2443258A1 (en) 2002-11-28
EP1390517A2 (en) 2004-02-25

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