CA2443258A1 - Replicons derived from positive strand rna virus genomes useful for the production of heterologous proteins - Google Patents
Replicons derived from positive strand rna virus genomes useful for the production of heterologous proteins Download PDFInfo
- Publication number
- CA2443258A1 CA2443258A1 CA002443258A CA2443258A CA2443258A1 CA 2443258 A1 CA2443258 A1 CA 2443258A1 CA 002443258 A CA002443258 A CA 002443258A CA 2443258 A CA2443258 A CA 2443258A CA 2443258 A1 CA2443258 A1 CA 2443258A1
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- protein
- rna
- virus
- positive strand
- dna
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Classifications
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32211—Cardiovirus, e.g. encephalomyocarditis virus
- C12N2770/32241—Use of virus, viral particle or viral elements as a vector
- C12N2770/32243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2820/00—Vectors comprising a special origin of replication system
- C12N2820/60—Vectors comprising a special origin of replication system from viruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
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Applications Claiming Priority (3)
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| US29251501P | 2001-05-23 | 2001-05-23 | |
| US60/292,515 | 2001-05-23 | ||
| PCT/IB2002/002810 WO2002095023A2 (en) | 2001-05-23 | 2002-05-23 | Replicons derived from positive strand rna virus genomes useful for the production of heterologous proteins |
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| CA2443258A1 true CA2443258A1 (en) | 2002-11-28 |
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| CA002443258A Abandoned CA2443258A1 (en) | 2001-05-23 | 2002-05-23 | Replicons derived from positive strand rna virus genomes useful for the production of heterologous proteins |
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| Country | Link |
|---|---|
| US (2) | US20030077251A1 (enExample) |
| EP (1) | EP1390517A2 (enExample) |
| JP (1) | JP2005508610A (enExample) |
| KR (1) | KR20040007567A (enExample) |
| CN (1) | CN1575339A (enExample) |
| AU (1) | AU2002339603A1 (enExample) |
| CA (1) | CA2443258A1 (enExample) |
| WO (1) | WO2002095023A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4157456A4 (en) * | 2020-05-29 | 2024-06-26 | Oncorus, Inc. | ENCAPSULATED RNA REPLICONS AND METHODS OF USE |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA05012542A (es) | 2003-06-05 | 2006-02-08 | Wyeth Corp | Composiciones inmunogenicas que comprenden vectores de replicon del virus de la encefalitis equina venezolana y antigenos de la proteina del paramixovirus. |
| KR100788894B1 (ko) | 2005-12-09 | 2007-12-27 | 한국전자통신연구원 | 확대된 서비스 영역을 제공하는 직교 주파수 분할 다중방식의 무선 랜 송수신 시스템 및 그 방법 |
| WO2008103755A1 (en) * | 2007-02-20 | 2008-08-28 | Mayo Foundation For Medical Education And Research | Treating cancer with viral nucleic acid |
| US9909192B2 (en) * | 2007-06-01 | 2018-03-06 | Universidad De Barcelona | Control for virus detection assays based on reverse-transcription polymerase chain reaction |
| EP2130912A1 (en) * | 2008-06-04 | 2009-12-09 | Institut für Viruskrankeiten und Immunprophylaxe | Pestivirus replicons providing an RNA-based viral vector system |
| ES2543222T3 (es) * | 2008-09-24 | 2015-08-17 | Ribomic Inc. | Aptámero para NGF y uso del mismo |
| PL2590676T3 (pl) | 2010-07-06 | 2017-02-28 | Glaxosmithkline Biologicals Sa | Wirionopodobne cząstki dostarczające dla autoreplikujących się cząsteczek rna |
| EP2591114B1 (en) | 2010-07-06 | 2016-06-08 | GlaxoSmithKline Biologicals SA | Immunisation of large mammals with low doses of rna |
| DK3243526T3 (da) | 2010-07-06 | 2020-02-17 | Glaxosmithkline Biologicals Sa | Levering af rna til at udløse flere immunsignalveje |
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| MX341989B (es) | 2010-08-31 | 2016-09-09 | Novartis Ag * | Liposomas pequeños para el suministro de arn que codifica el inmunogeno. |
| RS63315B1 (sr) | 2010-08-31 | 2022-07-29 | Glaxosmithkline Biologicals Sa | Pegilovani lipozomi za isporuku rnk koja kodira imunogen |
| CA2814386C (en) | 2010-10-11 | 2019-08-20 | Novartis Ag | Antigen delivery platforms |
| CA3198966A1 (en) | 2011-06-08 | 2012-12-13 | Translate Bio, Inc. | Cleavable lipids |
| US20140206753A1 (en) | 2011-06-08 | 2014-07-24 | Shire Human Genetic Therapies, Inc. | Lipid nanoparticle compositions and methods for mrna delivery |
| CA2840989A1 (en) | 2011-07-06 | 2013-01-10 | Novartis Ag | Immunogenic combination compositions and uses thereof |
| EP4115875A1 (en) * | 2011-07-06 | 2023-01-11 | GlaxoSmithKline Biologicals S.A. | Liposomes having useful n:p ratio for delivery of rna molecules |
| CN114231562A (zh) * | 2021-12-15 | 2022-03-25 | 中国科学院武汉病毒研究所 | 一种表达荧光素酶基因的淋巴脉络丛脑膜炎病毒及其构建方法和应用 |
| CN114317563B (zh) * | 2021-12-17 | 2023-09-05 | 华南理工大学 | 提高基因表达的rna复制子及其应用 |
| CN117070464A (zh) * | 2022-05-16 | 2023-11-17 | 上海行深生物科技有限公司 | 蛋白包裹自复制rna及其制备方法 |
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| GB9125896D0 (en) * | 1991-12-05 | 1992-02-05 | Almond Jeffrey W | Bicistronic viruses |
| WO1994029472A2 (en) * | 1993-06-03 | 1994-12-22 | Institut Pasteur | Mengovirus as a vector for expression of foreign polypeptides |
| US5811407A (en) * | 1997-02-19 | 1998-09-22 | The University Of North Carolina At Chapel Hill | System for the in vivo delivery and expression of heterologous genes in the bone marrow |
-
2002
- 2002-05-22 US US10/152,040 patent/US20030077251A1/en not_active Abandoned
- 2002-05-23 CA CA002443258A patent/CA2443258A1/en not_active Abandoned
- 2002-05-23 EP EP02743559A patent/EP1390517A2/en not_active Withdrawn
- 2002-05-23 AU AU2002339603A patent/AU2002339603A1/en not_active Abandoned
- 2002-05-23 WO PCT/IB2002/002810 patent/WO2002095023A2/en not_active Ceased
- 2002-05-23 KR KR10-2003-7014871A patent/KR20040007567A/ko not_active Withdrawn
- 2002-05-23 CN CNA028104889A patent/CN1575339A/zh active Pending
- 2002-05-23 JP JP2002592486A patent/JP2005508610A/ja not_active Withdrawn
- 2002-05-23 US US10/478,434 patent/US20050118566A1/en not_active Abandoned
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4157456A4 (en) * | 2020-05-29 | 2024-06-26 | Oncorus, Inc. | ENCAPSULATED RNA REPLICONS AND METHODS OF USE |
Also Published As
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|---|---|
| KR20040007567A (ko) | 2004-01-24 |
| WO2002095023A2 (en) | 2002-11-28 |
| CN1575339A (zh) | 2005-02-02 |
| AU2002339603A1 (en) | 2002-12-03 |
| JP2005508610A (ja) | 2005-04-07 |
| US20050118566A1 (en) | 2005-06-02 |
| WO2002095023A3 (en) | 2003-05-08 |
| US20030077251A1 (en) | 2003-04-24 |
| EP1390517A2 (en) | 2004-02-25 |
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