KR20040007567A - 양성쇄 rna 바이러스 게놈으로부터 유도되고이종단백질 생산에 유용한 레플리콘 - Google Patents

양성쇄 rna 바이러스 게놈으로부터 유도되고이종단백질 생산에 유용한 레플리콘 Download PDF

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KR20040007567A
KR20040007567A KR10-2003-7014871A KR20037014871A KR20040007567A KR 20040007567 A KR20040007567 A KR 20040007567A KR 20037014871 A KR20037014871 A KR 20037014871A KR 20040007567 A KR20040007567 A KR 20040007567A
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rna
protein
self
molecule
virus
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Korean (ko)
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니꼴라 에스크리우
실비 반데르베르프
마르코 비그누찌
실비 제르보
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엥스띠뛰 파스퇴르
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
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    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32211Cardiovirus, e.g. encephalomyocarditis virus
    • C12N2770/32241Use of virus, viral particle or viral elements as a vector
    • C12N2770/32243Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2840/00Vectors comprising a special translation-regulating system
    • C12N2840/20Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR10-2003-7014871A 2001-05-23 2002-05-23 양성쇄 rna 바이러스 게놈으로부터 유도되고이종단백질 생산에 유용한 레플리콘 Withdrawn KR20040007567A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29251501P 2001-05-23 2001-05-23
US60/292,515 2001-05-23
PCT/IB2002/002810 WO2002095023A2 (en) 2001-05-23 2002-05-23 Replicons derived from positive strand rna virus genomes useful for the production of heterologous proteins

Publications (1)

Publication Number Publication Date
KR20040007567A true KR20040007567A (ko) 2004-01-24

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KR10-2003-7014871A Withdrawn KR20040007567A (ko) 2001-05-23 2002-05-23 양성쇄 rna 바이러스 게놈으로부터 유도되고이종단백질 생산에 유용한 레플리콘

Country Status (8)

Country Link
US (2) US20030077251A1 (enExample)
EP (1) EP1390517A2 (enExample)
JP (1) JP2005508610A (enExample)
KR (1) KR20040007567A (enExample)
CN (1) CN1575339A (enExample)
AU (1) AU2002339603A1 (enExample)
CA (1) CA2443258A1 (enExample)
WO (1) WO2002095023A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE47522E1 (en) 2005-12-09 2019-07-16 Electronics And Telecommunications Research Institute Transmitting and receiving systems for increasing service coverage in orthogonal frequency division multiplexing wireless local area network, and method thereof

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MXPA05012542A (es) 2003-06-05 2006-02-08 Wyeth Corp Composiciones inmunogenicas que comprenden vectores de replicon del virus de la encefalitis equina venezolana y antigenos de la proteina del paramixovirus.
WO2008103755A1 (en) * 2007-02-20 2008-08-28 Mayo Foundation For Medical Education And Research Treating cancer with viral nucleic acid
US9909192B2 (en) * 2007-06-01 2018-03-06 Universidad De Barcelona Control for virus detection assays based on reverse-transcription polymerase chain reaction
EP2130912A1 (en) * 2008-06-04 2009-12-09 Institut für Viruskrankeiten und Immunprophylaxe Pestivirus replicons providing an RNA-based viral vector system
ES2543222T3 (es) * 2008-09-24 2015-08-17 Ribomic Inc. Aptámero para NGF y uso del mismo
PL2590676T3 (pl) 2010-07-06 2017-02-28 Glaxosmithkline Biologicals Sa Wirionopodobne cząstki dostarczające dla autoreplikujących się cząsteczek rna
EP2591114B1 (en) 2010-07-06 2016-06-08 GlaxoSmithKline Biologicals SA Immunisation of large mammals with low doses of rna
DK3243526T3 (da) 2010-07-06 2020-02-17 Glaxosmithkline Biologicals Sa Levering af rna til at udløse flere immunsignalveje
US9770463B2 (en) 2010-07-06 2017-09-26 Glaxosmithkline Biologicals Sa Delivery of RNA to different cell types
BR112013000244A2 (pt) 2010-07-06 2016-05-17 Novartis Ag lipossomas com lipídeos apresentando pka vantajoso para administração de rna
MX341989B (es) 2010-08-31 2016-09-09 Novartis Ag * Liposomas pequeños para el suministro de arn que codifica el inmunogeno.
RS63315B1 (sr) 2010-08-31 2022-07-29 Glaxosmithkline Biologicals Sa Pegilovani lipozomi za isporuku rnk koja kodira imunogen
CA2814386C (en) 2010-10-11 2019-08-20 Novartis Ag Antigen delivery platforms
CA3198966A1 (en) 2011-06-08 2012-12-13 Translate Bio, Inc. Cleavable lipids
US20140206753A1 (en) 2011-06-08 2014-07-24 Shire Human Genetic Therapies, Inc. Lipid nanoparticle compositions and methods for mrna delivery
CA2840989A1 (en) 2011-07-06 2013-01-10 Novartis Ag Immunogenic combination compositions and uses thereof
EP4115875A1 (en) * 2011-07-06 2023-01-11 GlaxoSmithKline Biologicals S.A. Liposomes having useful n:p ratio for delivery of rna molecules
KR20230019450A (ko) * 2020-05-29 2023-02-08 온코루스, 인크. 캡슐화된 rna 레플리콘 및 사용 방법
CN114231562A (zh) * 2021-12-15 2022-03-25 中国科学院武汉病毒研究所 一种表达荧光素酶基因的淋巴脉络丛脑膜炎病毒及其构建方法和应用
CN114317563B (zh) * 2021-12-17 2023-09-05 华南理工大学 提高基因表达的rna复制子及其应用
CN117070464A (zh) * 2022-05-16 2023-11-17 上海行深生物科技有限公司 蛋白包裹自复制rna及其制备方法
WO2024225374A1 (ja) * 2023-04-25 2024-10-31 慎治 小笠原 インフルエンザウイルスのRdRpによるvRNAの転写及び/又は複製を制御する方法、並びにその利用

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Publication number Priority date Publication date Assignee Title
GB9125896D0 (en) * 1991-12-05 1992-02-05 Almond Jeffrey W Bicistronic viruses
WO1994029472A2 (en) * 1993-06-03 1994-12-22 Institut Pasteur Mengovirus as a vector for expression of foreign polypeptides
US5811407A (en) * 1997-02-19 1998-09-22 The University Of North Carolina At Chapel Hill System for the in vivo delivery and expression of heterologous genes in the bone marrow

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE47522E1 (en) 2005-12-09 2019-07-16 Electronics And Telecommunications Research Institute Transmitting and receiving systems for increasing service coverage in orthogonal frequency division multiplexing wireless local area network, and method thereof

Also Published As

Publication number Publication date
WO2002095023A2 (en) 2002-11-28
CN1575339A (zh) 2005-02-02
AU2002339603A1 (en) 2002-12-03
JP2005508610A (ja) 2005-04-07
US20050118566A1 (en) 2005-06-02
WO2002095023A3 (en) 2003-05-08
US20030077251A1 (en) 2003-04-24
CA2443258A1 (en) 2002-11-28
EP1390517A2 (en) 2004-02-25

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Patent event date: 20031114

Patent event code: PA01051R01D

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