CN1559562A - Bolus of six drugs including Rehmannia - Google Patents
Bolus of six drugs including Rehmannia Download PDFInfo
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- CN1559562A CN1559562A CNA2004100218760A CN200410021876A CN1559562A CN 1559562 A CN1559562 A CN 1559562A CN A2004100218760 A CNA2004100218760 A CN A2004100218760A CN 200410021876 A CN200410021876 A CN 200410021876A CN 1559562 A CN1559562 A CN 1559562A
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- 239000003814 drug Substances 0.000 title abstract description 17
- 229940079593 drug Drugs 0.000 title description 7
- 241000405414 Rehmannia Species 0.000 title 1
- 239000000284 extract Substances 0.000 claims abstract description 55
- 239000000843 powder Substances 0.000 claims abstract description 50
- UILPJVPSNHJFIK-UHFFFAOYSA-N Paeonol Chemical compound COC1=CC=C(C(C)=O)C(O)=C1 UILPJVPSNHJFIK-UHFFFAOYSA-N 0.000 claims abstract description 31
- 239000000463 material Substances 0.000 claims abstract description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 55
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 44
- 238000002360 preparation method Methods 0.000 claims description 35
- 238000001694 spray drying Methods 0.000 claims description 35
- 238000001035 drying Methods 0.000 claims description 25
- 239000000706 filtrate Substances 0.000 claims description 25
- 238000004108 freeze drying Methods 0.000 claims description 25
- 238000001291 vacuum drying Methods 0.000 claims description 25
- 239000007788 liquid Substances 0.000 claims description 19
- YLTGFGDODHXMFB-UHFFFAOYSA-N isoacetovanillon Natural products COC1=CC=C(C(C)=O)C=C1O YLTGFGDODHXMFB-UHFFFAOYSA-N 0.000 claims description 15
- MLIBGOFSXXWRIY-UHFFFAOYSA-N paeonol Natural products COC1=CC=C(O)C(C(C)=O)=C1 MLIBGOFSXXWRIY-UHFFFAOYSA-N 0.000 claims description 15
- 238000004821 distillation Methods 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 10
- 238000004064 recycling Methods 0.000 claims description 10
- 238000010992 reflux Methods 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 238000005516 engineering process Methods 0.000 claims description 8
- 239000006187 pill Substances 0.000 claims description 7
- 239000002244 precipitate Substances 0.000 claims description 5
- 239000002775 capsule Substances 0.000 claims description 3
- 239000008187 granular material Substances 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 239000007901 soft capsule Substances 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 abstract description 25
- 240000005001 Paeonia suffruticosa Species 0.000 abstract 1
- 235000003889 Paeonia suffruticosa Nutrition 0.000 abstract 1
- 244000248825 Peltandra virginica Species 0.000 abstract 1
- 235000001188 Peltandra virginica Nutrition 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 230000007812 deficiency Effects 0.000 description 29
- 239000009220 Liuwei Dihuang Decoction Substances 0.000 description 12
- 241001465754 Metazoa Species 0.000 description 9
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- 241000699670 Mus sp. Species 0.000 description 5
- 208000024891 symptom Diseases 0.000 description 5
- 235000005903 Dioscorea Nutrition 0.000 description 4
- 241000234273 Dioscorea Species 0.000 description 4
- 235000000504 Dioscorea villosa Nutrition 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 235000004879 dioscorea Nutrition 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 238000001256 steam distillation Methods 0.000 description 4
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- 210000003734 kidney Anatomy 0.000 description 3
- 229920006008 lipopolysaccharide Polymers 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 230000000813 microbial effect Effects 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- DNXIKVLOVZVMQF-UHFFFAOYSA-N (3beta,16beta,17alpha,18beta,20alpha)-17-hydroxy-11-methoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]-yohimban-16-carboxylic acid, methyl ester Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(C(=O)OC)C(O)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 DNXIKVLOVZVMQF-UHFFFAOYSA-N 0.000 description 2
- LCQMZZCPPSWADO-UHFFFAOYSA-N Reserpilin Natural products COC(=O)C1COCC2CN3CCc4c([nH]c5cc(OC)c(OC)cc45)C3CC12 LCQMZZCPPSWADO-UHFFFAOYSA-N 0.000 description 2
- QEVHRUUCFGRFIF-SFWBKIHZSA-N Reserpine Natural products O=C(OC)[C@@H]1[C@H](OC)[C@H](OC(=O)c2cc(OC)c(OC)c(OC)c2)C[C@H]2[C@@H]1C[C@H]1N(C2)CCc2c3c([nH]c12)cc(OC)cc3 QEVHRUUCFGRFIF-SFWBKIHZSA-N 0.000 description 2
- 206010038743 Restlessness Diseases 0.000 description 2
- 230000000274 adsorptive effect Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000012869 ethanol precipitation Methods 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 2
- 229960003147 reserpine Drugs 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 1
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- 230000002496 gastric effect Effects 0.000 description 1
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- 238000001802 infusion Methods 0.000 description 1
- 239000008929 jingui shenqi Substances 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
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- 230000035807 sensation Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 229940034208 thyroxine Drugs 0.000 description 1
- XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
A Chinese medicine 'Six-element Dihuang' is prepared from 6 Chinese-medicinal materials. Its preparing process features that the tuckahoe is pulverized for high biologic utilization rate, the tree peony bark is steamed and spray-dried for high output rate of peonol, and the extracts are madeinto dried powder for high stability and low cost.
Description
Technical field: the present invention is a kind of preparation technology of Liuwei Dihuang preparation, belongs to technical field of Chinese medicines.
Background technology: six drugs containing rehmanniae is the representative prescription of traditional Chinese medical science nourishing kidney yin, by the JINGUI SHENQI WAN derivation.Be used for the treatment of diseases such as dizziness due to deficiency of kidney yin, the hyperactivity of deficient fire, tinnitus, soreness of the waist and knees, night sweat, seminal emission, feverish sensation in the palms and soles.The Chinese patent communique discloses 02134148.6 patent application and No. 02134100.1 patent application, and in these two patents, Poria all is to be ground into 100 purpose fine powders; The Cortex Moutan steam distillation is produced paeonol and is all taked crystalline method to collect paeonol; All be to make extractum in process of production, mix at last; In 02134148.6 patent application, also take medicinal liquid to cross the method for macroporous adsorptive resins.In the production method of existing Liuwei Dihuang preparation, Poria powder is broken into 100 purpose fine powders, and its dissolution is not high, and bioavailability is lower; The Cortex Moutan steam distillation is produced paeonol and is taked crystalline method to collect, and its yield is not high, and crystalline process is not to carry out under airtight condition, also easily by microbial contamination; Because extractum is perishable, need store in freezer, so cost is higher relatively, and is difficult for mix homogeneously in follow-up blended process; In addition, for this Chinese medicine preparation, owing to contain a large amount of hygroscopic materials such as lipopolysaccharide phlegmatic temperament in the medical material, medicinal liquid is crossed macroporous adsorptive resins and these hygroscopic materials all can not be removed, in the process of follow-up preparation process such as filling or tabletting, not easy to operate, and in the process that stores the also easy moisture absorption, and influence the quality of medicine.
Summary of the invention: the objective of the invention is to: a kind of preparation technology of Liuwei Dihuang preparation is provided, and this invention partly is ground into Poria greater than 100 purpose micropowders at prior art, to increase the rate of release and the burst size of medicine, bioavailability is improved; Take spray-dired method when the Cortex Moutan steam distillation is produced paeonol, its yield height, and the preparation process be under airtight condition, to carry out, be not easy by microbial contamination; In preparation process of the present invention, respectively extractum is made extract dry powder in addition, the extract dry powder stable performance need not store in freezer, and cost reduces relatively, and is easier to follow-up mix homogeneously; Medicinal liquid adopts the method for ethanol precipitation twice, can effectively hygroscopic materials such as the lipopolysaccharide in the medicinal liquid, phlegmatic temperament all be removed, and is convenient to the operation of follow-up preparation process such as filling or tabletting, and is difficult for the moisture absorption in the process that stores, and guarantees the quality of medicine.The present invention constitutes like this: the prescription of Liuwei Dihuang preparation consists of:
Radix Rehmanniae Preparata 1408 Cortex Moutans 528 Rhizoma Dioscoreaes 704
Fructus Corni 704 Rhizoma Alismatis 528 Poria 528
Method 1: Poria partly is ground into greater than 100 purpose micropowders, Fructus Corni adds 5-15 and doubly measures 95% alcohol reflux secondary, each 1 hour, filter, medicinal residues are standby, and filtrate recycling ethanol is condensed into extractum, with vacuum drying, spray drying or freeze-drying drying, be ground into the above extract dry powder of 40 orders again; The Cortex Moutan vapor distillation is collected distillate, and spray drying is ground into greater than 100 purpose micropowders; Medicinal liquid medicinal residues behind the extraction paeonol, Fructus Corni medicinal residues residue Poria add 5-15 times of water gaging with Radix Rehmanniae Preparata, Rhizoma Alismatis Rhizoma Dioscoreae and decoct three times, each 1 hour, filter, merging filtrate, be concentrated into extractum, adopt vacuum drying spray drying or freeze-drying drying, be ground into the above extract dry powder of 40 orders again; Add above-mentioned Poria micropowder, Fructus Corni extract dry powder and Cortex Moutan extract and appropriate amount of auxiliary materials, can make different preparations behind the mixing.
Method 2: the present invention can also partly be ground into Poria greater than 100 purpose micropowders, and the residue Poria decocts with water each 30 minutes three times, filter, merging filtrate is condensed into extractum, with vacuum drying, spray drying or freeze-drying drying, be ground into the above extract dry powder of 40 orders again; Fructus Corni adds 5-15 and doubly measures 95% alcohol reflux secondary, and each 1 hour, filter, medicinal residues are standby, and filtrate recycling ethanol is condensed into extractum, with vacuum drying, spray drying or freeze-drying drying, is ground into the above extract dry powder of 40 orders again; The Cortex Moutan vapor distillation, collect distillate, spray drying, be ground into greater than 100 purpose micropowders the medicinal liquid medicinal residues behind the extraction paeonol, Fructus Corni medicinal residues and Radix Rehmanniae Preparata Rhizoma Alismatis Rhizoma Dioscoreae add 5-15 times of water gaging and decoct each 1 hour three times, filter, merging filtrate is concentrated into the thick paste shape, twice of precipitate with ethanol, contain the alcohol amount at every turn and be 50-80%, reclaim ethanol, be condensed into extractum, use vacuum drying, spray drying or freeze-drying drying, be ground into the above extract dry powder of 40 orders again, add above-mentioned Poria micropowder, the Poria extract dry powder, Fructus Corni extract dry powder and Cortex Moutan extract and appropriate amount of auxiliary materials, mixing can be made different preparations by diverse ways again; Described preparation is all preparations, comprising: capsule, soft capsule, injection, granule, tablet, pill, micropill, concentrated pill, drop pill, slow releasing preparation, oral liquid, syrup.
Compared with prior art, the present invention is broken into Poria powder greater than 100 purpose micropowders, to increase the rate of release and the burst size of medicine, bioavailability is improved; Take spray-dired method when the Cortex Moutan steam distillation is produced paeonol, its yield height, and the preparation process be under airtight condition, to carry out, be not easy by microbial contamination; In preparation process of the present invention, respectively extractum is made extract dry powder in addition, the extract dry powder stable performance need not store in freezer, and cost reduces relatively, and is easier to follow-up mix homogeneously; Medicinal liquid adopts the method for ethanol precipitation twice, can effectively hygroscopic materials such as the lipopolysaccharide in the medicinal liquid, phlegmatic temperament all be removed, be convenient to the operation of follow-up preparation process such as filling or tabletting, and in the process that stores, be difficult for the moisture absorption, and the quality of assurance medicine has reached the purpose of inventing.
Utilize the pharmacological effect of the medicine that the present invention produces:
LIUWEIDIHUANG JIAONANG is to the therapeutical effect of deficiency of the kidney yin pattern of syndrome animal model:
One, experiment material:
1, medicine:
LIUWEIDIHUANG JIAONANG A: preparing specification according to the present invention's's " method 1 " method is 2 of the clinical usefulness of 0.5g/ grain twice, a time on the one.Every contains crude drug is 2.2 grams.
LIUWEIDIHUANG JIAONANG B: according to the method preparation of Chinese patent 02134100.1 " Chinese medicine Liuwei Dihuang preparation " record, specification is the 0.5g/ grain.2 of clinical usefulness twice, a time on the one.Every contains crude drug is 2.2 grams.
LIUWEIDIHUANG JIAONANG C: according to the present invention's's " method 2 " method preparation, specification is the 0.3g/ grain.The clinical twice-daily of using, each one.Every contains crude drug is 4.4 grams.
LIUWEIDIHUANG JIAONANG D: the method that goes up record according to patent 02134148.6 " production technology of LIUWEIDIHUANG JIAONANG " prepares, and specification is the 0.3g/ grain.The clinical twice-daily of using, each one.Every contains crude drug is 4.4 grams.
2, laboratory animal: cleaning level NIH male mice, body weight 18-22g is available from Guiyang Medical College.
Two, experimental technique:
1, the grouping of laboratory animal: 120 of cleaning level NIH male mices are divided into six groups at random: matched group, deficiency of YIN group, deficiency of YIN treatment A group, deficiency of YIN treatment B group, deficiency of YIN treatment C group, deficiency of YIN treatment D group, 20 every group.
2, animal deficiency of YIN modelling: thyroxine sheet and reserpine are ground to the powder altogether, and with the normal saline dilution, every Mouse thyroid every day plain 3mg, reserpine 0.02mg irritate stomach, totally seven days.Occur losing weight, thin and weak, restless, deficiency of YIN symptom such as be slow in action.
3, medication and dosage: get the content of LIUWEIDIHUANG JIAONANG A, B, add the solution that an amount of normal saline is made 13.3mg/ml respectively; Get the content of LIUWEIDIHUANG JIAONANG C, D, add solution that an amount of normal saline makes 4mg/ml respectively respectively by 0.5ml/ gastric infusion seven days only/day continuously, non-treatment group equivalent normal saline.Above process and modeling are carried out the same period.
4, observation index: observed and recorded symptom, body weight, survival rate in 10 days.
Three, result:
1, the observed result of animal symptom, body weight and survival rate: deficiency of YIN group performance restlessness, happiness drink transfer later on that lethargy, binocular are not opened, are slow in action, body weight descends rapidly, beginning on the 3rd is dead to.Deficiency of YIN treatment A organizes various deficiency of YIN symptoms and obviously alleviates, and becomes thin and weakens, and the behavior of most of animal appearance is normal, and beginning on the 6th is dead.Deficiency of YIN treatment B organizes various deficiency of YIN sxs, becomes thin and weakens, and the behavior of most of animal appearance is normal, and beginning on the 5th is dead.Deficiency of YIN treatment C organizes various deficiency of YIN symptoms and obviously alleviates, and becomes thin and weakens, and the behavior of most of animal appearance is normal, and beginning on the 7th is dead.Deficiency of YIN treatment D organizes various deficiency of YIN sxs, becomes thin and weakens, and the behavior of most of animal appearance is normal, and beginning on the 5th is dead.The results are shown in Table 1
Table 1 is respectively organized the comparison of body weight and survival rate
Body weight (g) surviving animals is counted survival rate (%)
Matched group 35.2 ± 4.8 20 100
Deficiency of YIN group 18.3 ± 1.3 4 20
Deficiency of YIN treatment A group 27.8 ± 2.5 13 65
Deficiency of YIN treatment B group 24.4 ± 3.2 9 45
Deficiency of YIN treatment C group 26.5 ± 2.8 12 60
Deficiency of YIN treatment D group 23.6 ± 2.9 10 50
Four, conclusion: experimental results show that by above, body weight of deficiency of YIN treatment group mice and survival rate are apparently higher than deficiency of YIN group, and body weight of deficiency of YIN treatment A group mice and survival rate are apparently higher than deficiency of YIN treatment B group, body weight of deficiency of YIN treatment C group mice and survival rate are apparently higher than deficiency of YIN treatment D group, so LIUWEIDIHUANG JIAONANG A is better than the therapeutic effect of LIUWEIDIHUANG JIAONANG B, LIUWEIDIHUANG JIAONANG C is more obvious than the therapeutic effect of LIUWEIDIHUANG JIAONANG D.
Embodiments of the invention 1:
Radix Rehmanniae Preparata 1408 Cortex Moutans 528 Rhizoma Dioscoreaes 704
Fructus Corni 704 Rhizoma Alismatis 528 Poria 528
Poria 422g is ground into 200 purpose micropowders, and Fructus Corni adds the alcohol reflux secondary of 10560ml 95%, each 1 hour, filter, medicinal residues are standby, filtrate recycling ethanol, be condensed into extractum,, be ground into 200 purpose extract dry powder again with vacuum drying, spray drying or freeze-drying drying; The Cortex Moutan vapor distillation is collected distillate, and spray drying is ground into 200 purpose micropowders; Medicinal liquid medicinal residues behind the extraction paeonol, Fructus Corni medicinal residues, residue Poria and Radix Rehmanniae Preparata, Rhizoma Alismatis, Rhizoma Dioscoreae add the 41190ml decocting and boil three times, each 1 hour, filter, merging filtrate, be concentrated into extractum, adopt vacuum drying, spray drying or freeze-drying drying, be ground into 200 purpose extract dry powder again; Add above-mentioned Poria micropowder, Fructus Corni extract dry powder and Cortex Moutan extract and appropriate amount of auxiliary materials, can make capsule behind the mixing.
Embodiments of the invention 2: Poria 422g is ground into 200 purpose micropowders, and the residue Poria decocts with water each 30 minutes three times, filter, merging filtrate is condensed into extractum, with vacuum drying, spray drying or freeze-drying drying, be ground into 200 purpose extract dry powder again; Fructus Corni adds the alcohol reflux secondary of 10560ml 95%, and each 1 hour, filter, medicinal residues are standby, and filtrate recycling ethanol is condensed into extractum, with vacuum drying, spray drying or freeze-drying drying, is ground into 200 purpose extract dry powder again; The Cortex Moutan vapor distillation, collect distillate, spray drying, be ground into 200 purpose micropowders, the medicinal liquid medicinal residues behind the extraction paeonol, Fructus Corni medicinal residues and Radix Rehmanniae Preparata, Rhizoma Alismatis, Rhizoma Dioscoreae adds the 39600ml decocting boils each 1 hour three times, filter, merging filtrate is concentrated into the thick paste shape, twice of precipitate with ethanol, contain the alcohol amount at every turn and be 80%, reclaim ethanol, be condensed into extractum, use vacuum drying, spray drying or freeze-drying drying, be ground into 200 purpose extract dry powder again, add above-mentioned Poria micropowder, Poria extract dry powder Fructus Corni extract dry powder and Cortex Moutan extract and appropriate amount of auxiliary materials, mixing, the method for prior art is made pill again.
The embodiment of the invention 3:
Radix Rehmanniae Preparata 1408 Cortex Moutans 528 Rhizoma Dioscoreaes 704
Fructus Corni 704 Rhizoma Alismatis 528 Poria 528
Poria 106g is ground into 120 purpose micropowders, and Fructus Corni adds the alcohol reflux secondary of 3520ml95%, each 1 hour, filter, medicinal residues are standby, filtrate recycling ethanol, be condensed into extractum,, be ground into 40 purpose extract dry powder again with vacuum drying, spray drying or freeze-drying drying; The Cortex Moutan vapor distillation is collected distillate, and spray drying is ground into 120 purpose micropowders; Medicinal liquid medicinal residues behind the extraction paeonol, Fructus Corni medicinal residues, residue Poria and Radix Rehmanniae Preparata, Rhizoma Alismatis, Rhizoma Dioscoreae add the 15310ml decocting and boil three times, each 1 hour, filter, merging filtrate, be concentrated into extractum, adopt vacuum drying, spray drying or freeze-drying drying, be ground into 40 purpose extract dry powder again; Add above-mentioned Poria micropowder, Fructus Corni extract dry powder and Cortex Moutan extract and appropriate amount of auxiliary materials, make granule behind the mixing.
Embodiments of the invention 4: Poria 106g is ground into 120 purpose micropowders, and the residue Poria decocts with water each 30 minutes three times, filter, merging filtrate is condensed into extractum, with vacuum drying, spray drying or freeze-drying drying, be ground into 40 purpose extract dry powder again; Fructus Corni adds the alcohol reflux secondary of 3520ml 95%, and each 1 hour, filter, medicinal residues are standby, and filtrate recycling ethanol is condensed into extractum, with vacuum drying, spray drying or freeze-drying drying, is ground into 40 purpose extract dry powder again; The Cortex Moutan vapor distillation, collect distillate, spray drying, be ground into 120 purpose micropowders, medicinal liquid medicinal residues behind the extraction paeonol, Fructus Corni medicinal residues and Radix Rehmanniae Preparata, Rhizoma Alismatis, Rhizoma Dioscoreae adds the 13200ml decocting boils three times, each 1 hour, filters, merging filtrate, be concentrated into the thick paste shape, precipitate with ethanol twice contains the alcohol amount at every turn and is 50%, reclaim ethanol, be condensed into extractum, use vacuum drying, spray drying or freeze-drying drying are ground into 40 purpose extract dry powder again, add above-mentioned Poria micropowder, the Poria extract dry powder, Fructus Corni extract dry powder and Cortex Moutan extract and appropriate amount of auxiliary materials can be made oral liquid behind the mixing.
The embodiment of the invention 5:
Radix Rehmanniae Preparata 1408 Cortex Moutans 528 Rhizoma Dioscoreaes 704
Fructus Corni 704 Rhizoma Alismatis 528 Poria 528
Poria 350g is ground into 200 purpose micropowders, and Fructus Corni adds the alcohol reflux secondary of 5632ml95%, each 1 hour, filter, medicinal residues are standby, filtrate recycling ethanol, be condensed into extractum,, be ground into 200 purpose extract dry powder again with vacuum drying, spray drying or freeze-drying drying; The Cortex Moutan vapor distillation is collected distillate, and spray drying is ground into 200 purpose micropowders; Medicinal liquid medicinal residues behind the extraction paeonol, Fructus Corni medicinal residues residue Poria and Radix Rehmanniae Preparata, Rhizoma Alismatis, Rhizoma Dioscoreae add the 22544ml decocting and boil three times, each 1 hour, filter, merging filtrate, be concentrated into extractum, adopt vacuum drying, spray drying or freeze-drying drying, be ground into 200 purpose extract dry powder again; Add above-mentioned Poria micropowder, Fructus Corni extract dry powder and Cortex Moutan extract and appropriate amount of auxiliary materials, can make tablet behind the mixing.
Embodiments of the invention 6: Poria 110g is ground into 200 purpose micropowders, and the residue Poria decocts with water each 30 minutes three times, filter, merging filtrate is condensed into extractum, with vacuum drying, spray drying or freeze-drying drying, be ground into 200 purpose extract dry powder again; Fructus Corni adds the alcohol reflux secondary of 5632ml95%, and each 1 hour, filter, medicinal residues are standby, and filtrate recycling ethanol is condensed into extractum, with vacuum drying, spray drying or freeze-drying drying, is ground into 200 purpose extract dry powder again; The Cortex Moutan vapor distillation, collect distillate, spray drying, be ground into 200 purpose micropowders, medicinal liquid medicinal residues behind the extraction paeonol, Fructus Corni medicinal residues and Radix Rehmanniae Preparata, Rhizoma Alismatis, Rhizoma Dioscoreae adds the 21120ml decocting boils three times, each 1 hour, filters, merging filtrate, be concentrated into the thick paste shape, precipitate with ethanol twice contains the alcohol amount at every turn and is 70%, reclaim ethanol, be condensed into extractum, use vacuum drying, spray drying or freeze-drying drying are ground into 200 purpose extract dry powder again, add above-mentioned Poria micropowder, the Poria extract dry powder, Fructus Corni extract dry powder and Cortex Moutan extract and appropriate amount of auxiliary materials, mixing can be made injection by prior art again.
Claims (3)
- The preparation technology of 1 one kinds of Liuwei Dihuang preparations, the prescription of Liuwei Dihuang preparation is: Radix Rehmanniae Preparata Cortex Moutan Rhizoma Dioscoreae Fructus Corni Rhizoma Alismatis and Poria, it is characterized in that: Poria partly is ground into greater than 100 purpose micropowders, Fructus Corni adds 5-15 and doubly measures 95% alcohol reflux secondary, each 1 hour, filter, medicinal residues are standby, filtrate recycling ethanol, be condensed into extractum, with vacuum drying spray drying or freeze-drying drying, be ground into the above extract dry powder of 40 orders again, the Cortex Moutan vapor distillation, collect distillate, spray drying, be ground into greater than 100 purpose micropowders, medicinal liquid medicinal residues Fructus Corni medicinal residues residue Poria behind the extraction paeonol and Radix Rehmanniae Preparata Rhizoma Alismatis Rhizoma Dioscoreae add 5-15 times of water gaging and decoct three times, each 1 hour, filter, merging filtrate is concentrated into extractum, adopt vacuum drying spray drying or freeze-drying drying, be ground into the above extract dry powder of 40 orders again, add the Poria micropowder that obtains, Fructus Corni extract dry powder and Cortex Moutan extract and appropriate amount of auxiliary materials can be made different preparations behind the mixing.
- 2 preparation technologies according to the described Liuwei Dihuang preparation of claim 1, it is characterized in that: Poria partly is ground into greater than 100 purpose micropowders, the residue Poria decocts with water three times, each 30 minutes, filter, merging filtrate, be condensed into extractum, with vacuum drying spray drying or freeze-drying drying, be ground into the above extract dry powder of 40 orders again, Fructus Corni adds 5-15 and doubly measures 95% alcohol reflux secondary, each 1 hour, filter, medicinal residues are standby, filtrate recycling ethanol, be condensed into extractum,, be ground into the above extract dry powder of 40 orders again with vacuum drying spray drying or freeze-drying drying, the Cortex Moutan vapor distillation, collect distillate, spray drying is ground into greater than 100 purpose micropowders, medicinal liquid medicinal residues Fructus Corni medicinal residues behind the extraction paeonol and Radix Rehmanniae Preparata Rhizoma Alismatis Rhizoma Dioscoreae add 5-15 times of water gaging and decoct three times, each 1 hour, filter merging filtrate, be concentrated into the thick paste shape, precipitate with ethanol twice contains the alcohol amount at every turn and is 50-80%, reclaims ethanol, be condensed into extractum, with vacuum drying spray drying or freeze-drying drying, be ground into the above extract dry powder of 40 orders again, add the Poria micropowder Poria extract dry powder Fructus Corni extract dry powder and Cortex Moutan extract and the appropriate amount of auxiliary materials that obtain, mixing can be made different preparations by diverse ways again.
- 3 preparation technologies according to the described this Liuwei Dihuang preparation of claim 12 is characterized in that: described preparation comprises: capsule, soft capsule, injection, granule, tablet, pill, micropill, concentrated pill, drop pill, slow releasing preparation, oral liquid, syrup.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410021876 CN1241615C (en) | 2004-02-18 | 2004-02-18 | Bolus of six drugs including Rehmannia |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200410021876 CN1241615C (en) | 2004-02-18 | 2004-02-18 | Bolus of six drugs including Rehmannia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1559562A true CN1559562A (en) | 2005-01-05 |
| CN1241615C CN1241615C (en) | 2006-02-15 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200410021876 Expired - Lifetime CN1241615C (en) | 2004-02-18 | 2004-02-18 | Bolus of six drugs including Rehmannia |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948772A (en) * | 2014-05-20 | 2014-07-30 | 王庚禹 | Extract for preparing kidney-qi-tonifying preparation |
-
2004
- 2004-02-18 CN CN 200410021876 patent/CN1241615C/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103948772A (en) * | 2014-05-20 | 2014-07-30 | 王庚禹 | Extract for preparing kidney-qi-tonifying preparation |
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| Publication number | Publication date |
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| CN1241615C (en) | 2006-02-15 |
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