CN1478520A - Heat-clearing and detoxic medicine and its preparation method - Google Patents
Heat-clearing and detoxic medicine and its preparation method Download PDFInfo
- Publication number
- CN1478520A CN1478520A CNA031299806A CN03129980A CN1478520A CN 1478520 A CN1478520 A CN 1478520A CN A031299806 A CNA031299806 A CN A031299806A CN 03129980 A CN03129980 A CN 03129980A CN 1478520 A CN1478520 A CN 1478520A
- Authority
- CN
- China
- Prior art keywords
- radix
- clearing
- cream
- medicine
- heat
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 23
- 238000002360 preparation method Methods 0.000 title claims description 12
- 241000255789 Bombyx mori Species 0.000 claims abstract description 10
- 206010068319 Oropharyngeal pain Diseases 0.000 claims abstract description 8
- 238000000034 method Methods 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 14
- 201000007100 Pharyngitis Diseases 0.000 claims description 12
- 239000006071 cream Substances 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims description 10
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 9
- 231100000614 poison Toxicity 0.000 claims description 7
- 239000003440 toxic substance Substances 0.000 claims description 7
- 241000628997 Flos Species 0.000 claims description 6
- QQILFGKZUJYXGS-UHFFFAOYSA-N Indigo dye Chemical compound C1=CC=C2C(=O)C(C3=C(C4=CC=CC=C4N3)O)=NC2=C1 QQILFGKZUJYXGS-UHFFFAOYSA-N 0.000 claims description 6
- 239000010231 banlangen Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 210000000582 semen Anatomy 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 3
- 239000000469 ethanolic extract Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 3
- 238000002203 pretreatment Methods 0.000 claims description 3
- 239000000443 aerosol Substances 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- 239000006196 drop Substances 0.000 claims description 2
- 239000000865 liniment Substances 0.000 claims description 2
- 229940040145 liniment Drugs 0.000 claims description 2
- 235000015091 medicinal tea Nutrition 0.000 claims description 2
- 239000012528 membrane Substances 0.000 claims description 2
- 239000003094 microcapsule Substances 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 239000000829 suppository Substances 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000000243 solution Substances 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000002994 raw material Substances 0.000 claims 1
- 241000205585 Aquilegia canadensis Species 0.000 abstract 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 abstract 1
- 241000736199 Paeonia Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 229940097275 indigo Drugs 0.000 abstract 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 208000023409 throat pain Diseases 0.000 abstract 1
- 208000016150 acute pharyngitis Diseases 0.000 description 5
- 206010001093 acute tonsillitis Diseases 0.000 description 5
- 206010010774 Constipation Diseases 0.000 description 4
- 206010022998 Irritability Diseases 0.000 description 4
- 206010037660 Pyrexia Diseases 0.000 description 4
- 210000003026 hypopharynx Anatomy 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 210000002784 stomach Anatomy 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 238000001035 drying Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000007888 film coating Substances 0.000 description 1
- 238000009501 film coating Methods 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
A Chinese medicine for antipyresis, detoxicating and treating throat pain is prepared from 16 Chinese-medicinal materials including silkworm excrement, natural indigo, red peony root, honeysuckle flower, etc. Its preparing process is also disclosed.
Description
Technical field
The present invention relates to a kind of heat-clearing and toxic substances removing, relieving sore throat and pain is used for laryngopharynx swelling and pain due to the accumulated heat in the lung and stomach, fever and irritability, constipation, infantile acute pharyngitis, heat-clearing and detoxic medicine of illness such as acute tonsillitis and preparation method thereof.
Background technology
At present existingly fall ball clearly and be used for heat-clearing and toxic substances removing, the relieving sore throat and pain curative effect is fine, but it is big to exist volume, the difficulty of swallowing, and mouthfeel is poor, absorbs not exclusively the shortcoming that bioavailability is not high.
Summary of the invention
In order to overcome the shortcoming of pill, the object of the present invention is to provide a kind of reasonable recipe, select YAOJING good, the bioavailability height, disintegrate is fast, and is scattered, mouthfeel is suitable, absorbs fully the micronization heat-clearing and toxic substances removing of increase evident in efficacy, relieving sore throat and pain, be used for laryngopharynx swelling and pain due to the accumulated heat in the lung and stomach, fever and irritability, constipation, infantile acute pharyngitis, the preparation medicine of illness such as acute tonsillitis.
Another kind of purpose of the present invention is to be to provide the Qingjiangpian tablets heat-clearing and toxic substances removing, and relieving sore throat and pain is used for laryngopharynx swelling and pain due to the accumulated heat in the lung and stomach, fever and irritability, constipation, infantile acute pharyngitis, the preparation method of the preparation medicine of illness such as acute tonsillitis.
To achieve these goals, the present invention takes following technical scheme.
Medicine of the present invention is made (consumption is a percentage ratio) by following component:
Silkworm excrement 7.93% Radix Et Rhizoma Rhei 7.93% Indigo Naturalis 3.97% Radix Scrophulariae 7.93% Semen Gleditsiae 7.93% Radix Paeoniae Rubra 7.93% Radix Isatidis 7.93% Fructus Forsythiae, 7.93% Cortex Moutan, 7.93% Radix Ophiopogonis 5.15% Radix Rehmanniae 7.93% Radix Glycyrrhizae 2.62% Rhizoma Imperatae 7.93% Flos Lonicerae 7.93% Mentholum 0.2% Bulbus Fritillariae Cirrhosae 0.83%
Make heat-clearing and detoxic medicine, shown in Figure of description, the preparation method of medicine of the present invention is:
1, branch is got every Chinese crude drug, concocts according to processing of Chinese Pharmacopoeia version in 2000 and is processed into the common Chinese decoction pieces.
2, with the crude drug Mentholum porphyrize after the pre-treatment, standby.
3, silkworm excrement, Radix Et Rhizoma Rhei, Indigo Naturalis, Bulbus Fritillariae Cirrhosae powder are broken into fine powder, cross 100 mesh sieves.
4, with Radix Scrophulariae, Semen Gleditsiae 80% ethanol, temperature is extracted secondary for 78 ℃, and each 1.5h merges ethanol extract, reclaims ethanol and is condensed into cream (relative density 1.30～1.35).
5, with Rhizoma Imperatae, Flos Lonicerae, Radix Paeoniae Rubra, Radix Isatidis, Radix Ophiopogonis, Fructus Forsythiae, Cortex Moutan, Radix Rehmanniae, 100 ℃ of decocting in water secondaries of Radix Glycyrrhizae difference, each 1.5h extracting solution is condensed into cream (relative density 1.35～1.40).
6, with water cream 30%, alcohol cream 5% merges and adds silkworm excrement etc., fine powder accounts for 54.75% and 10.25% adjuvant, mixing is made granule, drying, put cold, add the Mentholum powder, mix homogeneously is made tablet, powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, unguentum, medicated wine, syrup, oral solutions, medicinal tea, liniment, patch according to Chinese Pharmacopoeia version standard preparation in 2000.
Pharmaceutical preparation of the present invention can be used for heat-clearing and toxic substances removing, and relieving sore throat and pain is used for laryngopharynx swelling and pain due to the accumulated heat in the lung and stomach, fever and irritability, and constipation, infantile acute pharyngitis, the treatment of illness such as acute tonsillitis, clinical efficacy (clinical report is attached) significantly is better than falling clearly ball.
Key problem in technology of the present invention is the reasonable compatibility of above-mentioned 16 flavor Chinese medicines, and traditional and high-new preparation method.The micronization advanced technology that is included in the preparation process to be adopted, instrument and equipment with extraction, separate, the means of extraction.Because the above-mentioned crude drug of mentioning, the prepared slices of Chinese crude drugs or intermediate through the micronization processes technology, make extremely refinement of drug particles, form particle size and dwindle several times less than the 100nm volume than pill, be convenient to swallow, compliance is good, help the absorption of human body, and then improve bioavailability medicine.
Description of drawings
Fig. 1 is the Qingjiangpian tablets process chart.
The specific embodiment
Embodiment makes Qingjiangpian tablets (consumption is a weight portion) by aforementioned component, percentage ratio: silkworm excrement 20.84g, Radix Et Rhizoma Rhei 20.84g, Indigo Naturalis 10.42g, Radix Scrophulariae 20.84g, Semen Gleditsiae 20.84g, Radix Paeoniae Rubra 20.84g, Radix Isatidis 20.84g, Radix Ophiopogonis 20.84g, Fructus Forsythiae 20.84g, Cortex Moutan 13.54g, Radix Rehmanniae 20.84g, Radix Glycyrrhizae 6.88g, Rhizoma Imperatae 20.84g, Flos Lonicerae 20.84g, Mentholum 0.052g, Bulbus Fritillariae Cirrhosae 2.18g
1000
1, branch is got every Chinese crude drug, concocts according to processing of Chinese Pharmacopoeia version in 2000 and is processed into the common Chinese decoction pieces.
Below operate in the GMP cleaning shop;
2, with the crude drug Mentholum porphyrize after the pre-treatment, standby.
3, silkworm excrement, Radix Et Rhizoma Rhei, Indigo Naturalis, Bulbus Fritillariae Cirrhosae powder are broken into fine powder, cross 100 mesh sieves.
4, with Radix Scrophulariae, Semen Gleditsiae 80% ethanol, temperature is extracted secondary for 78 ℃, and each 1.5h merges ethanol extract, reclaims ethanol and is condensed into cream (relative density 1.30～1.35).
5, with Rhizoma Imperatae, Flos Lonicerae, Radix Paeoniae Rubra, Radix Isatidis, Radix Ophiopogonis, Fructus Forsythiae, Cortex Moutan, Radix Rehmanniae, 100 ℃ of decocting in water secondaries of Radix Glycyrrhizae difference, each 1.5h extracting solution is condensed into cream (relative density 1.35～1.40).
6, with water cream 30%, pure cream 5% merges and adds silkworm excrement etc., and fine powder accounts for 54.75% and 10.25% adjuvant, mixing, make granule, drying is put cold, add the Mentholum powder, mix homogeneously is made according to appendix rules of preparations of Chinese Pharmacopoeia version in 2000, and plain sheet adds sugar-coat or the film-coat mixed liquor is made coated tablet and versicolor film coating tablet, six years old patient of every weight 0.125g takes each 3 every day three times.
The Qingjiangpian tablets volume dwindles several times than pill, is convenient to swallow, and compliance is good, curative effect fine (seeing that Qingjiangpian tablets is treated children acute pharyngitis, acute tonsillitis m clinical report is attached).
Claims (2)
1, a kind of heat-clearing and toxic substances removing that is used for, the heat-clearing and detoxic medicine of relieving sore throat and pain, it is characterized in that it is the medicament that the micronization raw material of following percentage ratio is made: silkworm excrement 7.93%, Radix Et Rhizoma Rhei 7.93%, Indigo Naturalis 3.97%, Radix Scrophulariae 7.93%, Semen Gleditsiae 7.93%, Radix Paeoniae Rubra 7.93%, Radix Isatidis 7.93%, Radix Ophiopogonis 7.93%, Fructus Forsythiae 7.93%, Cortex Moutan 5.15%, Radix Rehmanniae 7.93%, Radix Glycyrrhizae 2.62%, Rhizoma Imperatae 7.93%, Flos Lonicerae 7.93%, Mentholum 0.2%, Bulbus Fritillariae Cirrhosae 0.83%, and adopt following method to make: to divide and get every Chinese crude drug, be processed into the common Chinese decoction pieces according to processing process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000, with the crude drug Mentholum porphyrize after the pre-treatment, standby, with silkworm excrement, Radix Et Rhizoma Rhei, Indigo Naturalis, Bulbus Fritillariae Cirrhosae powder is broken into fine powder, cross 100 mesh sieves, with Radix Scrophulariae, Semen Gleditsiae 80% ethanol, temperature is extracted secondary for 78 ℃, each 1.5h, merge ethanol extract, reclaim ethanol and be condensed into cream (relative density 1.30～1.35), with Rhizoma Imperatae, Flos Lonicerae, Radix Paeoniae Rubra, Radix Isatidis, Radix Ophiopogonis, Fructus Forsythiae, Cortex Moutan, Radix Rehmanniae, Radix Glycyrrhizae is 100 ℃ of decocting in water secondaries respectively, each 1.5h extracting solution is condensed into cream (relative density 1.35～1.40), with water cream 30%, alcohol cream 5% merges and adds silkworm excrement etc., fine powder accounts for 54.75% and 10.25% adjuvant, mixing, make granule, dry, put cold, add the Mentholum powder, mix homogeneously is made pharmaceutical preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
2, according to the described heat-clearing and toxic substances removing that is used for of claim 1, the pharmaceutical preparation of falling clearly of relieving sore throat and pain is characterized in that described medicine is pill, powder, suppository, tablet, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solutions, medicinal tea, liniment, patch.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031299806A CN1314434C (en) | 2003-06-04 | 2003-06-04 | Heat-clearing and detoxic medicine and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031299806A CN1314434C (en) | 2003-06-04 | 2003-06-04 | Heat-clearing and detoxic medicine and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1478520A true CN1478520A (en) | 2004-03-03 |
| CN1314434C CN1314434C (en) | 2007-05-09 |
Family
ID=34153671
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031299806A Expired - Lifetime CN1314434C (en) | 2003-06-04 | 2003-06-04 | Heat-clearing and detoxic medicine and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1314434C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102485262A (en) * | 2010-12-03 | 2012-06-06 | 天津中新药业集团股份有限公司达仁堂制药厂 | Traditional Chinese medicine composition with characteristics of clearing heat, detoxifying and relieving throat pain as well as its preparation method |
| CN104258029A (en) * | 2014-09-24 | 2015-01-07 | 苏州市天灵中药饮片有限公司 | Dropping pills with effects of diminishing inflammation, relieving pain and clearing heat from throat and preparation method thereof |
| CN104324117A (en) * | 2014-11-27 | 2015-02-04 | 孙乃红 | Traditional Chinese medicine for preparing defaecation paste |
| CN104940670A (en) * | 2015-05-29 | 2015-09-30 | 陈永泉 | Traditional Chinese medicine for treating tonsillitis |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1322569A (en) * | 2001-04-28 | 2001-11-21 | 天津同仁堂制药厂 | Method of preparing Qingjiangpian tablets for clearing heat and detoxicating |
-
2003
- 2003-06-04 CN CNB031299806A patent/CN1314434C/en not_active Expired - Lifetime
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102485262A (en) * | 2010-12-03 | 2012-06-06 | 天津中新药业集团股份有限公司达仁堂制药厂 | Traditional Chinese medicine composition with characteristics of clearing heat, detoxifying and relieving throat pain as well as its preparation method |
| CN104258029A (en) * | 2014-09-24 | 2015-01-07 | 苏州市天灵中药饮片有限公司 | Dropping pills with effects of diminishing inflammation, relieving pain and clearing heat from throat and preparation method thereof |
| CN104324117A (en) * | 2014-11-27 | 2015-02-04 | 孙乃红 | Traditional Chinese medicine for preparing defaecation paste |
| CN104940670A (en) * | 2015-05-29 | 2015-09-30 | 陈永泉 | Traditional Chinese medicine for treating tonsillitis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1314434C (en) | 2007-05-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1899535A (en) | Method for preparing dermopathic blood toxic capsule | |
| CN1947757B (en) | Leave of glutinous rehmannia extractive, its preparation method and use, medicines prepared with said extractives | |
| CN1724040A (en) | Chinese patent drug for treating infantile cold and repeated cold, and its prepn. method | |
| CN102526517B (en) | Traditional Chinese medicinal composition for treating influenzas and preparation method thereof | |
| CN102228547B (en) | Application of traditional Chinese medicine composition in preparing medicaments treating pancreatitis and/or cholecystitis | |
| CN101390970B (en) | Traditional Chinese medicine for treating hepatitis B and preparation method thereof | |
| CN1059122C (en) | Antipyretic and antitoxic particles and preparing method thereof | |
| CN1314434C (en) | Heat-clearing and detoxic medicine and its preparation method | |
| CN102274394A (en) | Chinese medicinal composition for treating postnatal constipation | |
| CN111358906B (en) | Traditional Chinese medicine composition suitable for exogenous diseases | |
| CN1985944A (en) | Chinese medicine composition for treating cutaneous pruritus, rubella and other diseases | |
| CN1113794A (en) | Tea for relieving sore-throat to recover voice | |
| CN100367929C (en) | Preparation of Chinese traditional medicine for curing female inflammation and preparation method | |
| CN1335174A (en) | Stomatopathy and throat disease treating health care medicine and its production process | |
| CN100411666C (en) | Broad-specturm medicine for treating snake venom poisoning | |
| CN1712060A (en) | Preparation of Chinese medicinal mixture for treating gynecologic menstrual disease | |
| CN108186821B (en) | Traditional Chinese medicine composition for treating nervous headache and preparation method and application thereof | |
| CN1309367C (en) | Preparation of Chinese traditional medicine for curing gallstone and preparation method | |
| CN1350868A (en) | Medicine for preventing and treating cold and its preparing process | |
| CN101194959B (en) | Capsule for treating headache and method for preparing the same | |
| CN1060663C (en) | Compound Tibet capillary artemisia patent medicine | |
| CN1241625C (en) | Chinese medicine product with functions of detoxifying in 3 days and eliminating withdrawl syndrome | |
| CN1123683A (en) | Series products of radix notoginseng and cortex eucommiae and their productions | |
| CN1739729A (en) | Xiaokeling prepn for treating diabetes and its prepn process | |
| CN1686186A (en) | Eight-Gem capsule and its preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: TIANJIN TONGRENTANG GROUP CO., LTD. Free format text: FORMER NAME: TIANJIN TONGRENTANG CO., LTD. |
|
| CP03 | Change of name, title or address |
Address after: 300385 Tianjin Saida Xiqing Economic Development Zone No. 1 eight branch Patentee after: TIANJIN TONGRENTANG GROUP Co.,Ltd. Address before: 300132 Hongqiao District of Tianjin City West Street No. 126 in the village Patentee before: TIANJIN TONGRENTANG Co.,Ltd. |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Heat-clearing and detoxic medicine and its preparation method Effective date of registration: 20150713 Granted publication date: 20070509 Pledgee: China Minsheng Banking Corp Tianjin branch Pledgor: TIANJIN TONGRENTANG GROUP Co.,Ltd. Registration number: 2015120000035 |
|
| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20160928 Granted publication date: 20070509 Pledgee: China Minsheng Banking Corp Tianjin branch Pledgor: TIANJIN TONGRENTANG GROUP Co.,Ltd. Registration number: 2015120000035 |
|
| PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
| CX01 | Expiry of patent term |
Granted publication date: 20070509 |
|
| CX01 | Expiry of patent term |