CN1739729A - Xiaokeling prepn for treating diabetes and its prepn process - Google Patents
Xiaokeling prepn for treating diabetes and its prepn process Download PDFInfo
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- CN1739729A CN1739729A CN 200510032068 CN200510032068A CN1739729A CN 1739729 A CN1739729 A CN 1739729A CN 200510032068 CN200510032068 CN 200510032068 CN 200510032068 A CN200510032068 A CN 200510032068A CN 1739729 A CN1739729 A CN 1739729A
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Abstract
The present invention is Xiaokeling oral liquid and capsule prepared with 11 kinds of Chinese medicinal materials including rehmannia root, schisandra, ophiopogon root, peony bark, astragalus root, etc. The Xiaokeling oral liquid and capsule is superior to available Xiaokeling tablet, and has simple production process, greatly lowered production cost and capacity of meeting patient in regular taking. Especially, the Xiaokeling oral liquid enters to the gastrointestinal tract directly for fast absorption, high bioavailability, short time of reaching the required bacteriostasis concentration, high curative effect, convenient taking and less side effect.
Description
One, technical field:
The present invention relates to a kind of is raw material with Radix Rehmanniae, Fructus Schisandrae Chinensis, Radix Ophiopogonis, Cortex Moutan, the Radix Astragali, Rhizoma Coptidis, Poria, Radix Ginseng Rubra, Radix Trichosanthis, Gypsum Fibrosum, Fructus Lycii 11 flavor Chinese medicines, quench one's thirst Ling oral liquid and the capsule that are prepared from.Relate in particular to quench one's thirst Ling oral liquid and capsule and preparation method thereof.
Two, background technology:
The dosage form of the existing clever preparation of quenching one's thirst is a tablet, taken in the clever sheet of quenching one's thirst of state-promulgated pharmacopoeia, as the medicine of a kind of nourishing kidney yin, promoting the production of body fluid to quench thirst, QI invigorating blood sugar lowering, be mainly used in the Chinese patent medicine of the adult light medium-sized diabetes of non-insulin-dependent of treatment, it is evident in efficacy.Yet, produce the tablet complex process, the production cost height; Disintegrate is slow, is unfavorable for absorbing; Bioavailability is not high; Dose is big, needs 8 at every turn, and patient is difficult to accept; Cause the intestines and stomach side effect easily.
Three, summary of the invention:
The object of the present invention is to provide a kind of Ling oral liquid preparation and capsule preparations and preparation method thereof of quenching one's thirst,, improve bioavailability and curative effect, satisfy needs of medical treatment better to reduce the production cost.
Technical scheme of the present invention is: a kind of clever preparation of quenching one's thirst, it is formulated to press component by following medicine, and its component is: Radix Rehmanniae 20-80 part, Fructus Schisandrae Chinensis 1.4-6 part, Radix Ophiopogonis 10-40 part, Cortex Moutan 1.4-6 part, Radix Astragali 10-40 part, Rhizoma Coptidis 1-4 part, Poria 1.6-6.8 part, Radix Ginseng Rubra 1-4 part, Radix Trichosanthis 10-40 part, Gypsum Fibrosum 5-20 part, Fructus Lycii 5-40 part.Best component is: 20 parts of Radix Rehmanniae, 1.5 parts of Fructus Schisandrae Chinensis, 10 parts of Radix Ophiopogonis, 1.5 parts of Cortex Moutans, 10 parts of the Radixs Astragali, 1 part of Rhizoma Coptidis, 1.7 parts in Poria, 1 part of Radix Ginseng Rubra, 10 parts of Radix Trichosanthis, 5 parts in Gypsum Fibrosum, 10 parts of Fructus Lycii.
Preparation of the present invention can be prepared into quench one's thirst Ling oral liquid or Xiaokelin capsule for diabetes according to different production methods.
The preparation method of the Ling oral liquid of quenching one's thirst of the present invention is:
A, get Radix Rehmanniae, Fructus Schisandrae Chinensis, Radix Ophiopogonis, Cortex Moutan, the Radix Astragali, Rhizoma Coptidis, Poria, Radix Ginseng Rubra, Radix Trichosanthis, Gypsum Fibrosum, Fructus Lycii 11 flavor Chinese medicines and clean respectively, standby after the assay was approved;
B, 11 flavor Chinese medicines all are ground into fine powder, mix, decoct with water 3 times, each 2-3 hour, merge decoction liquor, left standstill 12 hours, filter, filtrate; The 4-12 that wherein decocts amount of water for the 1st time and be Chinese medicine weight doubly decocted 3 hours, the 2nd amount of water be 4-10 doubly, decocted 2 hours, the 3rd amount of water be 4-8 doubly, decocted 1 hour, filtrate is suitably concentrated, get concentrated solution;
C, concentrated solution is added suitable quantity of water and correctives, fully stir mix homogeneously.Promptly get the present invention's Ling oral liquid of quenching one's thirst.
The preparation method of Xiaokelin capsule for diabetes of the present invention is:
A, Cortex Moutan, Rhizoma Coptidis, Poria, Radix Ginseng Rubra, Radix Trichosanthis, Gypsum Fibrosum are made fine powder;
B, Radix Rehmanniae, Fructus Schisandrae Chinensis, Radix Ophiopogonis, the Radix Astragali, Fructus Lycii are decocted with water 3 times, each 2-3 hour, merge decoction liquor, left standstill 12 hours, filter, filtrate; The 4-12 that wherein decocts amount of water for the 1st time and be Chinese medicine weight doubly decocted 3 hours, and the 2nd time amount of water is 4-10 times, decocted 2 hours, the 3rd time amount of water is 4-8 times, decocts 1 hour, filter, get filtrate, 80 ℃ of decompression states are concentrated into the clear paste that relative density is 1.32-1.39 with filtrate;
C, above-mentioned fine powder and clear paste are fully mixed, drying is ground into fine powder, and mix homogeneously is made granule, drying, filled capsules.Promptly get Xiaokelin capsule for diabetes of the present invention.
Oral liquid formulation of the present invention and capsule formulation have remedied the defective of tablet, and the processing technology of the feasible clever preparation of quenching one's thirst is more simple and practical, greatly reduces production cost, satisfies the needs that the patient takes for a long time to medicine; Oral liquid formulation makes medicine directly enter the intestines and stomach especially, absorbs sooner, and bioavailability is higher, and it is shorter to reach the required time of effective Mlc, so curative effect is more remarkable; Take and convenience, side effect is littler.
Four, the specific embodiment:
Embodiment 1: get Radix Rehmanniae 200 gram, Fructus Schisandrae Chinensis 15 grams, Radix Ophiopogonis 100 gram, Cortex Moutan 15 grams, the Radix Astragali 100 grams, Rhizoma Coptidis 10 grams, Poria 17 grams, Radix Ginseng Rubra 10 grams, Radix Trichosanthis 100 grams, Gypsum Fibrosum 50 grams, Fructus Lycii 100 grams, preparation production technology according to the Ling oral liquid of quenching one's thirst, make 1200 ml solns, fill becomes the oral liquid of 10 milliliters or 20 milliliters.
Embodiment 2: get Radix Rehmanniae 200 gram, Fructus Schisandrae Chinensis 15 grams, Radix Ophiopogonis 100 gram, Cortex Moutan 15 grams, the Radix Astragali 100 grams, Rhizoma Coptidis 10 grams, Poria 17 grams, Radix Ginseng Rubra 10 grams, Radix Trichosanthis 100 grams, Gypsum Fibrosum 50 grams, Fructus Lycii 100 grams, preparation production technology according to the Ling oral liquid of quenching one's thirst, make 600 ml solns, fill becomes the oral liquid of 10 milliliters or 20 milliliters.
Embodiment 3: get Radix Rehmanniae 200 gram, Fructus Schisandrae Chinensis 15 grams, Radix Ophiopogonis 100 gram, Cortex Moutan 15 grams, the Radix Astragali 100 grams, Rhizoma Coptidis 10 grams, Poria 17 grams, Radix Ginseng Rubra 10 grams, Radix Trichosanthis 100 grams, Gypsum Fibrosum 50 grams, Fructus Lycii 100 grams, preparation production technology according to the Ling oral liquid of quenching one's thirst, make 2400 ml solns, fill becomes the oral liquid of 10 milliliters or 20 milliliters.
Embodiment 4: get Radix Rehmanniae 200 gram, Fructus Schisandrae Chinensis 15 grams, Radix Ophiopogonis 100 gram, Cortex Moutan 15 grams, the Radix Astragali 100 grams, Rhizoma Coptidis 10 grams, Poria 17 grams, Radix Ginseng Rubra 10 grams, Radix Trichosanthis 100 grams, Gypsum Fibrosum 50 grams, Fructus Lycii 100 grams, preparation production technology according to the Ling oral liquid of quenching one's thirst, make 4800 ml solns, fill becomes the oral liquid of 10 milliliters or 20 milliliters.
Embodiment 5: get Radix Rehmanniae 200 gram, Fructus Schisandrae Chinensis 15 grams, Radix Ophiopogonis 100 gram, Cortex Moutan 15 grams, the Radix Astragali 100 grams, Rhizoma Coptidis 10 grams, Poria 17 grams, Radix Ginseng Rubra 10 grams, Radix Trichosanthis 100 grams, Gypsum Fibrosum 50 grams, Fructus Lycii 100 grams, preparation production technology according to the Ling oral liquid of quenching one's thirst, make 9600 ml solns, fill becomes the oral liquid of 10 milliliters or 20 milliliters.
Embodiment 6: get Radix Rehmanniae 400 gram, Fructus Schisandrae Chinensis 30 grams, Radix Ophiopogonis 200 gram, Cortex Moutan 30 grams, the Radix Astragali 200 grams, Rhizoma Coptidis 20 grams, Poria 34 grams, Radix Ginseng Rubra 20 grams, Radix Trichosanthis 200 grams, Gypsum Fibrosum 100 grams, Fructus Lycii 200 grams, preparation production technology according to the Ling oral liquid of quenching one's thirst, make 1200 ml solns, fill becomes the oral liquid of 10 milliliters or 20 milliliters.
Embodiment 7: get Radix Rehmanniae 400 gram, Fructus Schisandrae Chinensis 30 grams, Radix Ophiopogonis 200 gram, Cortex Moutan 30 grams, the Radix Astragali 200 grams, Rhizoma Coptidis 20 grams, Poria 34 grams, Radix Ginseng Rubra 20 grams, Radix Trichosanthis 200 grams, Gypsum Fibrosum 100 grams, structure Fructus Lycii 200 grams, preparation production technology according to the Ling oral liquid of quenching one's thirst, make 600 ml solns, fill becomes the oral liquid of 10 milliliters or 20 milliliters.
Embodiment 8: get Radix Rehmanniae 400 gram, Fructus Schisandrae Chinensis 30 grams, Radix Ophiopogonis 200 gram, Cortex Moutan 30 grams, the Radix Astragali 200 grams, Rhizoma Coptidis 20 grams, Poria 34 grams, Radix Ginseng Rubra 20 grams, Radix Trichosanthis 200 grams, Gypsum Fibrosum 100 grams, Fructus Lycii 200 grams, preparation production technology according to the Ling oral liquid of quenching one's thirst, make 2400 ml solns, fill becomes the oral liquid of 10 milliliters or 20 milliliters.
Embodiment 9: get Radix Rehmanniae 400 gram, Fructus Schisandrae Chinensis 30 grams, Radix Ophiopogonis 200 gram, Cortex Moutan 30 grams, the Radix Astragali 200 grams, Rhizoma Coptidis 20 grams, Poria 34 grams, Radix Ginseng Rubra 20 grams, Radix Trichosanthis 200 grams, Gypsum Fibrosum 100 grams, Fructus Lycii 200 grams, preparation production technology according to the Ling oral liquid of quenching one's thirst, make 4800 ml solns, fill becomes the oral liquid of 10 milliliters or 20 milliliters.
Embodiment 10: get Radix Rehmanniae 400 gram, Fructus Schisandrae Chinensis 30 grams, Radix Ophiopogonis 200 gram, Cortex Moutan 30 grams, the Radix Astragali 200 grams, Rhizoma Coptidis 20 grams, Poria 34 grams, Radix Ginseng Rubra 20 grams, Radix Trichosanthis 200 grams, Gypsum Fibrosum 100 grams, Fructus Lycii 200 grams, preparation production technology according to the Ling oral liquid of quenching one's thirst, make 9600 ml solns, fill becomes the oral liquid of 10 milliliters or 20 milliliters.
Embodiment 11: get Radix Rehmanniae 200 gram, Fructus Schisandrae Chinensis 15 grams, Radix Ophiopogonis 100 gram, Cortex Moutan 15 grams, the Radix Astragali 100 grams, Rhizoma Coptidis 10 grams, Poria 17 grams, Radix Ginseng Rubra 10 grams, Radix Trichosanthis 100 grams, Gypsum Fibrosum 50 grams, Fructus Lycii 100 grams, according to the preparation production technology of Xiaokelin capsule for diabetes, make 960 capsules.
Embodiment 12: get Radix Rehmanniae 200 gram, Fructus Schisandrae Chinensis 15 grams, Radix Ophiopogonis 100 gram, Cortex Moutan 15 grams, the Radix Astragali 100 grams, Rhizoma Coptidis 10 grams, Poria 17 grams, Radix Ginseng Rubra 10 grams, Radix Trichosanthis 100 grams, Gypsum Fibrosum 50 grams, Fructus Lycii 100 grams, according to the preparation production technology of Xiaokelin capsule for diabetes, make 480 capsules.
Embodiment 13: get Radix Rehmanniae 200 gram, Fructus Schisandrae Chinensis 15 grams, Radix Ophiopogonis 100 gram, Cortex Moutan 15 grams, the Radix Astragali 100 grams, Rhizoma Coptidis 10 grams, Poria 17 grams, Radix Ginseng Rubra 10 grams, Radix Trichosanthis 100 grams, Gypsum Fibrosum 50 grams, Fructus Lycii 100 grams, according to the preparation production technology of Xiaokelin capsule for diabetes, make 1920 capsules.
Embodiment 14: get Radix Rehmanniae 400 gram, Fructus Schisandrae Chinensis 30 grams, Radix Ophiopogonis 200 gram, Cortex Moutan 30 grams, the Radix Astragali 200 grams, Rhizoma Coptidis 20 grams, Poria 34 grams, Radix Ginseng Rubra 20 grams, Radix Trichosanthis 200 grams, Gypsum Fibrosum 100 grams, Fructus Lycii 200 grams, according to the preparation production technology of Xiaokelin capsule for diabetes, make 960 capsules.
Embodiment 15: get Radix Rehmanniae 400 gram, Fructus Schisandrae Chinensis 30 grams, Radix Ophiopogonis 200 gram, Cortex Moutan 30 grams, the Radix Astragali 200 grams, Rhizoma Coptidis 20 grams, Poria 34 grams, Radix Ginseng Rubra 20 grams, Radix Trichosanthis 200 grams, Gypsum Fibrosum 100 grams, Fructus Lycii 200 grams, according to the preparation production technology of Xiaokelin capsule for diabetes, make 480 capsules.
Embodiment 16: get Radix Rehmanniae 400 gram, Fructus Schisandrae Chinensis 30 grams, Radix Ophiopogonis 200 gram, Cortex Moutan 30 grams, the Radix Astragali 200 grams, Rhizoma Coptidis 20 grams, Poria 34 grams, Radix Ginseng Rubra 20 grams, Radix Trichosanthis 200 grams, Gypsum Fibrosum 100 grams, Fructus Lycii 200 grams, according to the preparation production technology of Xiaokelin capsule for diabetes, make 1920 capsules.
Claims (3)
1, a kind of clever preparation of quenching one's thirst, it is formulated to press component by following medicine, and its component is: Radix Rehmanniae 20-80 part, Fructus Schisandrae Chinensis 1.4-6 part, Radix Ophiopogonis 10-40 part, Cortex Moutan 1.4-6 part, Radix Astragali 10-40 part, Rhizoma Coptidis 1-4 part, Poria 1.6-6.8 part, Radix Ginseng Rubra 1-4 part, Radix Trichosanthis 10-40 part, Gypsum Fibrosum 5-20 part, Fructus Lycii 5-40 part; Best component is: 20 parts of Radix Rehmanniae, 1.5 parts of Fructus Schisandrae Chinensis, 10 parts of Radix Ophiopogonis, 1.5 parts of Cortex Moutans, 10 parts of the Radixs Astragali, 1 part of Rhizoma Coptidis, 1.7 parts in Poria, 1 part of Radix Ginseng Rubra, 10 parts of Radix Trichosanthis, 5 parts in Gypsum Fibrosum, 10 parts of Fructus Lycii.
2, the preparation method of the oral liquid of the clever preparation of quenching one's thirst according to claim 1 is characterized in that:
A, get Radix Rehmanniae, Fructus Schisandrae Chinensis, Radix Ophiopogonis, Cortex Moutan, the Radix Astragali, Rhizoma Coptidis, Poria, Radix Ginseng Rubra, Radix Trichosanthis, Gypsum Fibrosum, Fructus Lycii 11 flavor Chinese medicines and clean respectively, standby after the assay was approved;
B, 11 flavor Chinese medicines all are ground into fine powder, mix, decoct with water 3 times, each 2-3 hour, merge decoction liquor, left standstill 12 hours, filter, filtrate; The 4-12 that wherein decocts amount of water for the 1st time and be Chinese medicine weight doubly decocted 3 hours, the 2nd amount of water be 4-10 doubly, decocted 2 hours, the 3rd amount of water be 4-8 doubly, decocted 1 hour, filtrate is suitably concentrated, get concentrated solution;
C, concentrated solution is added suitable quantity of water and correctives, fully stir mix homogeneously.
3, the capsular preparation method of the clever preparation of quenching one's thirst according to claim 1 is characterized in that:
A, Cortex Moutan, Rhizoma Coptidis, Poria, Radix Ginseng Rubra, Radix Trichosanthis, Gypsum Fibrosum are made fine powder;
B, Radix Rehmanniae, Fructus Schisandrae Chinensis, Radix Ophiopogonis, the Radix Astragali, Fructus Lycii are decocted with water 3 times, each 2-3 hour, merge decoction liquor, left standstill 12 hours, filter, filtrate; The 4-12 that wherein decocts amount of water for the 1st time and be Chinese medicine weight doubly decocted 3 hours, and the 2nd time amount of water is 4-10 times, decocted 2 hours, the 3rd time amount of water is 4-8 times, decocts 1 hour, filter, get filtrate, 80 ℃ of decompression states are concentrated into the clear paste that relative density is 1.32-1.39 with filtrate;
C, above-mentioned fine powder and clear paste are fully mixed, drying is ground into fine powder, and mix homogeneously is made granule, drying, filled capsules.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510032068 CN1739729A (en) | 2005-08-30 | 2005-08-30 | Xiaokeling prepn for treating diabetes and its prepn process |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510032068 CN1739729A (en) | 2005-08-30 | 2005-08-30 | Xiaokeling prepn for treating diabetes and its prepn process |
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| Publication Number | Publication Date |
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| CN1739729A true CN1739729A (en) | 2006-03-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 200510032068 Pending CN1739729A (en) | 2005-08-30 | 2005-08-30 | Xiaokeling prepn for treating diabetes and its prepn process |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101745027A (en) * | 2010-01-29 | 2010-06-23 | 药都制药集团股份有限公司 | Preparation method of xiaokeling condensed pill |
| CN101411786B (en) * | 2008-11-21 | 2011-04-06 | 汝州市中医院 | Diabetic capsule containing trichosanthin, rhizoma coptidis and ginseng |
-
2005
- 2005-08-30 CN CN 200510032068 patent/CN1739729A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101411786B (en) * | 2008-11-21 | 2011-04-06 | 汝州市中医院 | Diabetic capsule containing trichosanthin, rhizoma coptidis and ginseng |
| CN101745027A (en) * | 2010-01-29 | 2010-06-23 | 药都制药集团股份有限公司 | Preparation method of xiaokeling condensed pill |
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Open date: 20060301 |