CN1557467A - Extraction and concentration combined pure Chinese medicinal preparation for treating cardiovascular diseases - Google Patents
Extraction and concentration combined pure Chinese medicinal preparation for treating cardiovascular diseases Download PDFInfo
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- CN1557467A CN1557467A CNA2004100049071A CN200410004907A CN1557467A CN 1557467 A CN1557467 A CN 1557467A CN A2004100049071 A CNA2004100049071 A CN A2004100049071A CN 200410004907 A CN200410004907 A CN 200410004907A CN 1557467 A CN1557467 A CN 1557467A
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Abstract
The present invention is one kind of Chinese medicine preparation, named Xinmaikang capsule, for treating cardiac vascular diseases and its preparation process. The recipe consists of over thirty kinds of Chinese medicinal materials, including puerarin, ginsenoside, hirudin, ginkgetin, American ginseng, etc. Its preparation includes superfine crushing technological process and it is made into capsule. It is suitable for arteriosclerosis. Hypertension, rheumatism and other cardiac vascular diseases, and has high effective rate and curative rate.
Description
The technical field Chinese medicine preparation
The background technology cardiovascular disease is a kind of common blood circulation diseases.Its prevalence is ascendant trend year by year in the world, and especially in developing country, growth rate is faster.Its mortality rate has occupied second afterwards in tumor, and human beings'health and life in serious harm.Therefore, be the key subjects of current field of medicaments to the research of cardiovascular disease new drug in the world.So the inventor is in conjunction with my tcm clinical practice practice for many years, with the chinese tradition theory of Chinese medical science is criterion, in conjunction with the modern scientific research achievement, adopt modern high technology to extract concentration technique, invented a kind of extraction and the concentrated pure Chinese medicinal preparation " Xinmaikang medicine capsule " that combines that is specifically designed to the treatment cardiovascular disease.And through clinical, curative effect is distinguished.
Summary of the invention one, preparation are formed: puerarin 50g, ginsenoside 20 g, ligustrazine 30g, hirudin 15g, ginkgetin 20g, berberine 15g, Radix Panacis Quinquefolii
Extract powder50g, Radix Salviae Miltiorrhizae
Extract powder50, Sanguis Draxonis
Grind into powder50g, Radix Notoginseng
Extract powder50g, Pollen Typhae
Extract powder10g, RADIX CURCUMAE
Extract powder10g, Radix Polygoni Multiflori
Extract powder20g, Bulbus Allii Macrostemonis
Extract powder20g, Herb Gynostemmae Pentaphylli
Extract powder50g, Radix Aconiti Lateralis Preparata
Extract powder10g, natural Calculus Bovis
Grind into powder50g, the Radix Astragali
Extract powder50g, Rhizoma Zingiberis
Extract powder15g, Radix Glycyrrhizae
Extract powder15g, Radix Platycodonis
Extract powder10g, Rhizoma Cimicifugae
Extract powder10g, Ramulus Cinnamomi
Extract powder20g, Pericarpium Trichosanthis
Extract powder20g, Fructus Aurantii Immaturus
Extract powder20g, Styrax
Extract powder20g, Borneolum Syntheticum
Grind into powder30g.
Two, the side separates: puerarin in the side: be to extract from the dry Radix Puerariae of legume pueraria lobata.Modern pharmacological research proves: the effect with coronary artery dilator and cerebrovascular function; Have coronary blood flow increasing and cerebral blood flow, reduce the effect of myocardial oxygen consumption; Have the reduction packed cell volume, antiplatelet aggregation reduces whole blood viscosity and plasma viscosity.Thereby improve the effect of the gas exchange of lung and tissue; Ginsenoside: be from the root of Araliaceae herbaceos perennial Radix Ginseng, to extract.Have strongly invigorating primordial QI, multiple arteries and veins takes off invigorating the spleen to benefit the lung, the effect of promoting the production of body fluid and nourishing blood admittedly.Modern pharmacological research proves: have the cholesterol regulating metabolism, suppress the effect that high bile alcoholemia takes place; Low dose can make cardiac contractile force strengthen, and the effect characteristics are similar to cardiotonic glycoside; Ligustrazine: be from Umbelliferae herbaceos perennial Rhizoma Chuanxiong rhizome, to extract.Has blood-activating and qi-promoting, the effect of wind-expelling pain-stopping.Modern pharmacological research proves: have the effect that reduces the surface activity of blood platelet anticoagulant; Has the microcirculatory effect of the myocardial ischemia of improvement situation and mesentery; Has the effect that vascular smooth muscle shrinks that suppresses; Hirudin: be from the Hirudinidae animal, expanded letter money trematodiasis, dark brown trematodiasis, or fresh all middle extractions of blood-eating hirudo.Has removing blood stasis, the effect that diffusing disease is stimulated the menstrual flow.Modern pharmacological research proves: having has tangible dissolving and regressive effect to the atherosclerosis of aorta speckle; Have cholesterol, triglyceride, beta lipoprotein is effective, and especially the effect to triglyceride is more obvious.Has the expansion peripheral blood vessel, the effect of blood flow increasing and minimizing vascular resistance; Ginkgetin: be from the leaf of Ginkgoaceae plant Ginkgo biloba, to extract.Has invigorating blood circulation analgesia, the effect of astringing the lung and relievining asthma.Be used for the treatment of coronary heart disease, angina pectoris, hypertension, hyperlipidemia, hypercholesterolemia disease, cough and asthma due to lung deficiency etc.Modern pharmacological research proves: have coronary artery dilator, eliminate the effect of vascular smooth muscle spasm; Simultaneously cerebral vasospasm also there is good effect; Radix Panacis Quinquefolii: be the root of Araliaceae herbaceos perennial Radix Panacis Quinquefolii.Effect with boosting qi and nourishing yin.Modern pharmacological research proves: have and resist myocardial ischemia; Anti-myocardium oxidation; Anti-myocardial ischemia; Resisting fatigue; The effect of anti-stress; Has the antiarrhythmic effect; Radix Salviae Miltiorrhizae: be the root and rhizome of Labiatae herbaceos perennial Radix Salviae Miltiorrhizae.Has promoting blood circulation to restore menstrual flow, the effect of calming the nerves.Modern pharmacological research proves: have the effect that increases blood capillary tension force and reduce vascular fragility; Have and promote to block the reparation and the regeneration of cardiac muscular tissue; Have by activating the fibrinolysin system, impel fibrinolysis, be transformed into the effect of fibrin catabolite; Sanguis Draxonis: be the resin of the evergreen liana Sanguis Draxonis of Palmae.Effect with promoting blood circulation and stopping pain.Modern pharmacological research proves: the effect with remarkable shortening plasma in rabbit recalcification time; Have remarkable anticoagulant, prevent thrombotic effect; Radix Notoginseng: be the root of Araliaceae herbaceos perennial Radix Notoginseng.Has removing stasis to stop bleeding, the effect of promoting blood circulation and stopping pain.Modern pharmacological research proves: have anticoagulant, promote fibrinolytic, the effect that impels whole blood viscosity to descend; Have the formation that promotes the collateral circulation of arteria coronaria infarct, increase kinemic effect; Pollen Typhae: be the pollen of Typhaceae aquatic herbaceous plant raupo Herba Typhae, typha orientalis or congener.Has astringing to arrest bleeding, blood circulation promoting and blood stasis dispelling, the effect of diuresis.Modern pharmacological research proves: the effect with Antithrombin III vigor; Have and to suppress the intestinal absorption cholesterol, change the effect of lipid composition; Radix Polygoni Multiflori, RADIX CURCUMAE: two flavor medicine combinations have promoting the circulation of QI to relieve pain, the effect of tranquilizing by nourishing the heart.Modern pharmacological research proves: has and obviously prevents and alleviate aorta, and the formation and the lipidosis of coronary artery and branch's inner membrance speckle thereof, thus alleviate the effect that atherosclerosis forms; Have concurrently simultaneously and suppress experimental rabbit anteserum cholesterol rising and reduce the Absorption of rabbit intestinal cholesterol; Bulbus Allii Macrostemonis: be the bulb of wild Chinese onion of liliaceous plant or Allium macrostemon.Has the chest stuffiness relieving of regulating the flow of vital energy, the effect of activating YANG and eliminating stagnation.Modern pharmacological research proves: has the promotion fibrinolysis, reduces tremulous pulse lipid speckle, and blood fat, serum lipid peroxide, anticoagulant and release reaction suppress the outgrowth effect of arterial smooth muscle cell; Herb Gynostemmae Pentaphylli: for calabash is taken root in thing Herb Gynostemmae Pentaphylli rhizome or herb.Effect with eliminating inflammation and expelling toxin.Modern pharmacological research proves: have the content of remarkable reduction serum total cholesterol and low-density lipoprotein Pseudobulbus Bletillae (Rhizoma Bletillae) very low density lipoprotein (VLDL), and the obviously effect of blood fat reducing; Have the effect that brings high blood pressure down simultaneously concurrently; Radix Aconiti Lateralis Preparata: be the processed goods of the daughter root of Ranunculaceae herbaceos perennial Aconitum carmichjaelii Debx..Has recuperating depleted YANG and rescuing the patient from collapse, supporing yang benefit fire, the effect of dispersing cold for relieving pain.Modern pharmacological research proves: have tangible cardiotonic; Has the effect that resists myocardial ischemia; Has significant analgesia role; Natural Calculus Bovis: be the cholelithiasis of bovid cattle or Babalus bubalis L..Has removing heat from the heart to restore the consciousness, eliminating phlegm arresting convulsion, the effect of heat-clearing and toxic substances removing.Having has good remarkable persistent hypotensive effect to blood circulation; Have calmness and spasmolysis; Has stronger cardiotonic; The Radix Astragali: be the root of leguminous plant Radix Astragali and Inner Mongolia Astragalis.Effect with tonifying Qi and lifting yang.Modern pharmacological research proves: have the effect that improves host immune function; Has the systaltic effect of reinforcement; Especially to the heart of depletion, its cardiotonic is more remarkable; Rhizoma Zingiberis, Radix Glycyrrhizae: two the flavor medicines are compatible has promoting the flow of QI-blood by warming the meridian, yang invigorating activating QI, an effect of opening lung-energy.Pericarpium Trichosanthis: be the shell of the mature fruit of Cucurbitaceae herbaceous perennial vine plant Chinese juniper beach wormwood and bilateral Chinese juniper beach wormwood.Has removing heat-phlegm, the effect of relieving stuffiness of the chest by dispersing aggregation of pathogens.Modern pharmacological research proves: have the effect of eliminating the phlegm with blood fat reducing; Fructus Aurantii Immaturus: be the young fruit of Rutaceae evergreen dungarunga plant Citrus aurantium Linn. and variety or Fructus Citri sinensis.Have dispelling the stagnated QI and remove painful abdominal mass, the effect of transforming phlegm and dispersing accumulations.Modern pharmacological research proves: have the arteria coronaria of increasing, brain, renal blood flow, reduce the effect of brain, renal vascular resistance; Styrax, Borneolum Syntheticum: have the refreshment of having one's ideas straightened out, the resolving depression eliminating phlegm is warded off the effect of dirty pain relieving.Two flavor medicines are compatible, bring out the best in each other, and are usually used in treating coronary heart disease, angina pectoris etc.Can alleviate pain relieving quickly, function well and lasting, and have no side effect.Modern pharmacological research proves: the effect with platelet aggregation inhibitory activity; Having has decreased heart rate to myocardial infarction, improves the effect of coronary flow and reduction myocardial oxygen consumption; The Borneolum Syntheticum Herba indigoferae Pseudotinctoriae, through evidence: absorb rapidly through mesentery, administration can be passed through blood brain barrier in five minutes, and it is long to accumulate the time at brain, and dose is also quite high.This medicine can reach the effect that the heart and brain disease is ruled together as guiding drug and treatment cardiovascular and cerebrovascular disease medicine compatibility.All medicine compatibilities have benefiting QI and nourishing blood, blood stasis dispelling blood fat reducing, multiple beniol sun, heart tonifying diuresis, the effect of the pain relieving of having one's ideas straightened out.Its pharmacology: have the myocardial ischemia of improvement, reduce the effect of infarction size; Have the minimizing myocardial oxygen consumption, obviously reduce the exponential effect of myocardial oxygen consumption; Has the effect that suppresses cardiovascular spasm; Have and reduce the deposition of cholesterol, the effectively effect of blood fat reducing in blood vessel wall; Have anti-angiogenic parietal cell necrosis, come off, prevent thrombotic effect; Has remarkable shortening plasma recalcification time, the recurrence effect once more of anti-tampon; Has the dissolving speckle, the effect that purifies the blood; Have the intestinal absorption of inhibition cholesterol, change the effect of blood fat composition; Have and promote to block the reparation and the regeneration of cardiac muscular tissue; Has the effect that reduces surface activity of blood platelet; Effect with mediator's body immunity function;
Three, indication and function: be applicable to coronary atherosclerosis, hypertension, caused heart disease of symptoms such as rheumatism and cardiovascular disease.Good especially to coronary atherosclerotic heart disease and complication therapeutic effect especially.Function: the effect of benefiting QI and nourishing blood, blood stasis dispelling blood fat reducing, multiple beniol sun, heart tonifying diuresis, the pain relieving of having one's ideas straightened out.
Four, usage and consumption: capsule.Every day three times, each 2-3 grain (tachycardia patient's dosage can reduce by half according to my situation and take).The suggestion patient must take medicine by adhering to the course of treatment, otherwise poor effect.30 days is a course of treatment.
1., the related Chinese medicine extract of above prescription the specific embodiment one, preparation method:; Adopt the high-tech extractive technique to extract → separate → drying → coarse powder → standby.2., Radix Salviae Miltiorrhizae adopts Radix Salviae simplicifoliae to be used as medicine in the prescription; The Radix Astragali adopts Radix Astragali (processed with Mel) to be used as medicine; Radix Ginseng adopts Radix Ginseng Rubra to be used as medicine.3. hirudin extracts in the prescription, must adopt bright Hirudo to extract.4., will fill a prescription in Chinese medicine except Sanguis Draxonis, natural Calculus Bovis, Borneolum Syntheticum, adopt respectively without exception to concentrate.Adopt superelevation times concentration technique (ratio of concentrating can not be lower than 15%), cold drying.5., with extract and extract powder, Sanguis Draxonis, natural Calculus Bovis, Borneolum Syntheticum is used as medicine together, mixes thoroughly.6., adopt modern superfine powder technology to process.7., sterilization treatment.8., encapsulated.Every contains clean medicine 0.4 gram (400 milligrams).
Two, dosage form and requirement: dosage form is a capsule.(also can be developed into injection, sugar coated tablet).Every contains clean medicine 0.4 gram (400 milligrams).
Three, taboo and reaction: no obvious toxic-side effects.One after each meal.
Four, manner of packing: aluminium-plastic panel dress.0.4 * 10/plate of gram, 2 plates/box.
Claims (2)
1, a kind of extraction and the concentrated pure Chinese medicinal preparation " Xinmaikang medicine capsule " that combines for the treatment of cardiovascular disease.Its feature: Chinese medicine is compound forms by puerarin, ginsenoside, hirudin, ginkgetin, berberine, Radix Panacis Quinquefolii, Radix Salviae Miltiorrhizae, Radix Notoginseng, Herb Gynostemmae Pentaphylli, natural Calculus Bovis, Sanguis Draxonis etc. 27 flavor.Adopting modern high technology superfine powder technology that compatibility Chinese medicine is carried out micropowder then handles.Dosage form is capsule (also can be developed into injection).Every capsules is 0.4 gram.
2, according to power 1 described Chinese medicine preparation, its feature: respectively with puerarin, ginsenoside, hirudin, ginkgetin, berberine, adopt modern extraction technique that extract is separated out by prescription.All the other Chinese medicines adopt high-tech ultra concentration technology to concentrate (ratio of concentrating can not be lower than 15%), cold drying except Sanguis Draxonis, natural Calculus Bovis, Borneolum Syntheticum.Combine with extract then, mix thoroughly.Adopt the superfine powder technology to process.Sterilization treatment, preparation.
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| CNA2004100049071A CN1557467A (en) | 2004-02-09 | 2004-02-09 | Extraction and concentration combined pure Chinese medicinal preparation for treating cardiovascular diseases |
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| CNA2004100049071A CN1557467A (en) | 2004-02-09 | 2004-02-09 | Extraction and concentration combined pure Chinese medicinal preparation for treating cardiovascular diseases |
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| CN1557467A true CN1557467A (en) | 2004-12-29 |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100415259C (en) * | 2005-04-25 | 2008-09-03 | 丁大愚 | Medicine for treating coronary heart disease and preparation thereof |
| CN101849967A (en) * | 2010-06-02 | 2010-10-06 | 苏店第二卫生所 | Medicament for curing apoplexy hemiplegy sequela and preparation method thereof |
| CN102038940A (en) * | 2009-10-09 | 2011-05-04 | 伍丽娟 | Hirudin combination medicament for treating cardiovascular and cerebrovascular diseases |
| CN103006769A (en) * | 2013-01-05 | 2013-04-03 | 山东沃华医药科技股份有限公司 | Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN103316302A (en) * | 2013-07-08 | 2013-09-25 | 陈静静 | Chinese medicine formula for treating angina pectoris |
| CN104095913A (en) * | 2014-07-31 | 2014-10-15 | 杜志政 | Fructus liquidambaris medicine composition and preparation method thereof |
| CN104107424A (en) * | 2014-07-31 | 2014-10-22 | 杜志政 | Qi cultivating thrombolytic medicinal composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN112220889A (en) * | 2019-06-26 | 2021-01-15 | 席圣林 | Traditional Chinese medicine for preventing and treating cardiovascular and cerebrovascular diseases and preparation method thereof |
-
2004
- 2004-02-09 CN CNA2004100049071A patent/CN1557467A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100415259C (en) * | 2005-04-25 | 2008-09-03 | 丁大愚 | Medicine for treating coronary heart disease and preparation thereof |
| CN102038940A (en) * | 2009-10-09 | 2011-05-04 | 伍丽娟 | Hirudin combination medicament for treating cardiovascular and cerebrovascular diseases |
| CN101849967A (en) * | 2010-06-02 | 2010-10-06 | 苏店第二卫生所 | Medicament for curing apoplexy hemiplegy sequela and preparation method thereof |
| CN101849967B (en) * | 2010-06-02 | 2011-11-09 | 苏店第二卫生所 | Medicament for curing apoplexy hemiplegy sequela and preparation method thereof |
| CN103006769A (en) * | 2013-01-05 | 2013-04-03 | 山东沃华医药科技股份有限公司 | Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN103006769B (en) * | 2013-01-05 | 2015-07-08 | 山东沃华医药科技股份有限公司 | Traditional Chinese medicine composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| CN103316302A (en) * | 2013-07-08 | 2013-09-25 | 陈静静 | Chinese medicine formula for treating angina pectoris |
| CN104095913A (en) * | 2014-07-31 | 2014-10-15 | 杜志政 | Fructus liquidambaris medicine composition and preparation method thereof |
| CN104107424A (en) * | 2014-07-31 | 2014-10-22 | 杜志政 | Qi cultivating thrombolytic medicinal composition for treating cardiovascular and cerebrovascular diseases and preparation method thereof |
| EP3175861A4 (en) * | 2014-07-31 | 2017-08-02 | Zhizheng Du | Pharmaceutical composition for treating cardiovascular or cerebrovascular diseases and preparation method therefor |
| CN112220889A (en) * | 2019-06-26 | 2021-01-15 | 席圣林 | Traditional Chinese medicine for preventing and treating cardiovascular and cerebrovascular diseases and preparation method thereof |
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