CN1556707A - 使用选择性iNOS抑制剂的眼科疾病治疗方法 - Google Patents

使用选择性iNOS抑制剂的眼科疾病治疗方法 Download PDF

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Publication number
CN1556707A
CN1556707A CNA028185854A CN02818585A CN1556707A CN 1556707 A CN1556707 A CN 1556707A CN A028185854 A CNA028185854 A CN A028185854A CN 02818585 A CN02818585 A CN 02818585A CN 1556707 A CN1556707 A CN 1556707A
Authority
CN
China
Prior art keywords
alkyl
product
alkoxy
halogen
nmr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA028185854A
Other languages
English (en)
Chinese (zh)
Inventor
Pt
P·T·马宁
���ɶ��ؼ�����
J·R·康纳尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia LLC
Original Assignee
Pharmacia LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia LLC filed Critical Pharmacia LLC
Publication of CN1556707A publication Critical patent/CN1556707A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNA028185854A 2001-09-24 2002-09-24 使用选择性iNOS抑制剂的眼科疾病治疗方法 Pending CN1556707A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/961,816 US20030109522A1 (en) 2001-09-24 2001-09-24 Ophthalmologic treatment methods using selective iNOS inhibitors
US09/961,816 2001-09-24

Publications (1)

Publication Number Publication Date
CN1556707A true CN1556707A (zh) 2004-12-22

Family

ID=25505060

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA028185854A Pending CN1556707A (zh) 2001-09-24 2002-09-24 使用选择性iNOS抑制剂的眼科疾病治疗方法

Country Status (13)

Country Link
US (1) US20030109522A1 (enExample)
EP (1) EP1429777A4 (enExample)
JP (1) JP2005506986A (enExample)
KR (1) KR20040039393A (enExample)
CN (1) CN1556707A (enExample)
AU (1) AU2002327041A2 (enExample)
BR (1) BR0212991A (enExample)
CA (1) CA2455910A1 (enExample)
IL (1) IL161004A0 (enExample)
MX (1) MXPA04002711A (enExample)
PL (1) PL369338A1 (enExample)
WO (1) WO2003026668A1 (enExample)
ZA (1) ZA200402285B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2354223T3 (es) * 2005-05-17 2011-03-11 Santen Pharmaceutical Co., Ltd. Derivados de amidina para uso en la prevención o el tratamiento de glaucoma.
CA3017042C (en) * 2016-03-07 2024-02-20 Centro Nacional De Investigaciones Cardiovasculares Carlos Iii (F.S.P.) In vitro method for identifying thoracic aortic aneurysms (taa) in a subject

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5132453A (en) * 1991-03-22 1992-07-21 Cornell Research Foundation, Inc. N6 -(hydrazinoiminomethyl)lysine and method of inhibiting nitric oxide formation in body
GB9127376D0 (en) * 1991-12-24 1992-02-19 Wellcome Found Amidino derivatives
US5684008A (en) * 1994-11-09 1997-11-04 G. D. Searle & Co. Aminotetrazole derivatives useful as nitric oxide synthase inhibitors
US5830917A (en) * 1995-09-11 1998-11-03 G. D. Searle & Co. L-N6 -(1-iminoethyl) lysine derivatives useful as nitric oxide synthase inhibitors
US5981511A (en) * 1996-03-06 1999-11-09 G.D. Searle & Co. Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors
US5945408A (en) * 1996-03-06 1999-08-31 G.D. Searle & Co. Hydroxyanidino derivatives useful as nitric oxide synthase inhibitors
GB9811599D0 (en) * 1998-05-30 1998-07-29 Glaxo Group Ltd Nitric oxide synthase inhibitors
KR100835265B1 (ko) * 2000-03-24 2008-06-09 파마시아 코포레이션 산화 질소 신타아제 억제제로 유용한 아미디노 화합물 및그들의 염
AR032318A1 (es) * 2000-04-13 2003-11-05 Pharmacia Corp Compuesto derivado halogenado del acido 2-amino-5,6 heptenoico; composicion farmaceutica que lo comprende y su uso en la fabricacion de un medicamento util como inhibidor de la oxido nitrico sintetasa

Also Published As

Publication number Publication date
BR0212991A (pt) 2004-08-17
AU2002327041A2 (en) 2003-04-07
EP1429777A4 (en) 2005-06-22
KR20040039393A (ko) 2004-05-10
JP2005506986A (ja) 2005-03-10
ZA200402285B (en) 2005-06-13
WO2003026668A1 (en) 2003-04-03
IL161004A0 (en) 2004-08-31
PL369338A1 (en) 2005-04-18
EP1429777A1 (en) 2004-06-23
US20030109522A1 (en) 2003-06-12
CA2455910A1 (en) 2003-04-03
MXPA04002711A (es) 2004-07-05

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PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication