CN1549719A - 孕烷二酮或二醇作为神经镇痛剂的应用 - Google Patents

孕烷二酮或二醇作为神经镇痛剂的应用 Download PDF

Info

Publication number
CN1549719A
CN1549719A CNA02817027XA CN02817027A CN1549719A CN 1549719 A CN1549719 A CN 1549719A CN A02817027X A CNA02817027X A CN A02817027XA CN 02817027 A CN02817027 A CN 02817027A CN 1549719 A CN1549719 A CN 1549719A
Authority
CN
China
Prior art keywords
alkyl
thiazolinyl
alkanoyl
formula
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA02817027XA
Other languages
English (en)
Chinese (zh)
Inventor
C��S���ŵ�ǡ����
C·S·古德恰尔德
�������ɭ
R·内德森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monash University
Original Assignee
Monash University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monash University filed Critical Monash University
Publication of CN1549719A publication Critical patent/CN1549719A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
CNA02817027XA 2001-08-28 2002-08-28 孕烷二酮或二醇作为神经镇痛剂的应用 Pending CN1549719A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPR7319A AUPR731901A0 (en) 2001-08-28 2001-08-28 Method of treatment
AUPR7319 2001-08-28

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNA2009101264152A Division CN101590062A (zh) 2001-08-28 2002-08-28 孕烷二酮或二醇作为神经镇痛剂的应用

Publications (1)

Publication Number Publication Date
CN1549719A true CN1549719A (zh) 2004-11-24

Family

ID=3831271

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA02817027XA Pending CN1549719A (zh) 2001-08-28 2002-08-28 孕烷二酮或二醇作为神经镇痛剂的应用
CNA2009101264152A Pending CN101590062A (zh) 2001-08-28 2002-08-28 孕烷二酮或二醇作为神经镇痛剂的应用

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNA2009101264152A Pending CN101590062A (zh) 2001-08-28 2002-08-28 孕烷二酮或二醇作为神经镇痛剂的应用

Country Status (10)

Country Link
US (2) US20050009796A1 (enExample)
EP (1) EP1450817A4 (enExample)
JP (1) JP2005504776A (enExample)
CN (2) CN1549719A (enExample)
AU (2) AUPR731901A0 (enExample)
BR (1) BR0212205A (enExample)
CA (1) CA2468466A1 (enExample)
MX (1) MXPA04001807A (enExample)
RU (1) RU2346690C2 (enExample)
WO (1) WO2003018027A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
GB0324423D0 (en) * 2003-10-18 2003-11-19 Vernalis Cambridge Ltd Analgesia method
US20060009432A1 (en) * 2004-07-09 2006-01-12 Roger Whiting Use of neurosteroids to treat neuropathic pain
RU2306929C1 (ru) * 2005-12-28 2007-09-27 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией индапамида и l-аргинина при l-name-индуцированном дефиците оксида азота
RU2306924C1 (ru) * 2005-12-28 2007-09-27 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией лозартана и резвератрола при l-name-индуцированном дефиците оксида азота
RU2296566C1 (ru) * 2005-12-28 2007-04-10 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией амлодипина и l-аргинина при l-name-индуцированном дефиците оксида азота
RU2306930C1 (ru) * 2005-12-28 2007-09-27 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией лозартана и l-аргинина при l-name-индуцированном дефиците оксида азота
RU2302241C1 (ru) * 2005-12-28 2007-07-10 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией индапамида и резвератрола при l-name-индуцированном дефиците оксида азота
JPWO2008120562A1 (ja) * 2007-04-02 2010-07-15 東洋紡績株式会社 帯状疱疹後神経痛治療用錠剤および帯状疱疹後神経痛の治療方法
RU2364393C1 (ru) * 2008-03-19 2009-08-20 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции пикамилоном при l-name индуцированном дефиците оксида азота
WO2010025316A1 (en) * 2008-08-29 2010-03-04 Jeffrey Comanor Composition and methods for relief of neuropathological pain

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1317184A (en) * 1969-06-20 1973-05-16 Glaxo Lab Ltd Steroid-containing pharmaceutical preparations
GB1373913A (en) * 1970-12-17 1974-11-13 Glaxo Lab Ltd Pharmaceutical compositions
US5888996A (en) * 1995-07-26 1999-03-30 Trustees Of Boston University Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity
JP4313435B2 (ja) * 1995-07-24 2009-08-12 トラスティーズ オブ ボストン ユニバーシティー プレグネノロンサルフェート誘導体によるｎｍｄａレセプター活性の抑制
AUPN498095A0 (en) * 1995-08-23 1995-09-14 Goodchild, Colin Stanley Compounds and compositions
GB9607034D0 (en) * 1996-04-03 1996-06-05 Leo Pharm Prod Ltd Chemical compounds
US6048848A (en) * 1996-08-23 2000-04-11 Monash University Use of pregnane-diones as analgesic agents
US6787530B1 (en) * 1996-08-23 2004-09-07 Monash University Use of pregnane-diones as analgesic agents
AU782250B2 (en) * 1999-08-31 2005-07-14 Trustees Of Boston University Effect of steroids on NMDA receptors depends on subunit composition
US20030027833A1 (en) * 2001-05-07 2003-02-06 Cleary Gary W. Compositions and delivery systems for administration of a local anesthetic agent

Also Published As

Publication number Publication date
RU2004109517A (ru) 2005-06-27
MXPA04001807A (es) 2005-03-07
US20050009796A1 (en) 2005-01-13
CA2468466A1 (en) 2003-03-06
EP1450817A1 (en) 2004-09-01
US20080227764A1 (en) 2008-09-18
BR0212205A (pt) 2004-09-21
AUPR731901A0 (en) 2001-09-20
WO2003018027A1 (en) 2003-03-06
AU2008202729A1 (en) 2008-07-17
RU2346690C2 (ru) 2009-02-20
CN101590062A (zh) 2009-12-02
EP1450817A4 (en) 2009-02-25
JP2005504776A (ja) 2005-02-17

Similar Documents

Publication Publication Date Title
JP6926065B2 (ja) 癌を治療するための方法
JP5921539B2 (ja) 下肢静止不能症候群を治療する方法
JP5650208B2 (ja) 薬物嗜癖の治療および嗜癖関連行動を改善するための組成物
US20080227764A1 (en) Use of pregnane-diones or diols as neuropathic analgesic agents
CN1703416A (zh) 包含一氧化氮供体和阿片样物质止痛剂的组合物和方法
CN1203864C (zh) 聚维酮碘喷雾剂
CN1531435A (zh) 抑制血管生成的方法
Dehuisser et al. Cardiovascular effects, induction and recovery characteristics and alfaxalone dose assessment in alfaxalone versus alfaxalone-fentanyl total intravenous anaesthesia in dogs
CN1607954A (zh) 用于治疗中枢神经系统功能紊乱的孕烷类固醇
Ramsey et al. Cerenia Prevents Perioperative Nausea and Vomiting and Improves Recovery in Dogs Undergoing Routine Surgery.
WO2024182074A1 (en) R-mdma for treatment of pain
CN1674903A (zh) 经鼻吸收用组合物
CN109758455A (zh) 胺类化合物的光学异构体治疗疼痛的医药用途
EP2014288A1 (en) Combination of benzyl-4, 5-dihydro-1H-imidazole derivative and an opioid receptor ligand
Yegin et al. Analgesic effects of intrathecal neostigmine in perianal surgery
JP6246272B2 (ja) オピオイドアゴニストと組み合わせたサミドルファン（ａｌｋｓ ３３）
WO2022052996A1 (zh) 原人参二醇类化合物在治疗疼痛和成瘾物质躯体依赖、精神依赖和成瘾的用途
CN1107333A (zh) 那布扶林镇痛剂的长效前体药物及其制备方法
CN107427508B (zh) 异喹啉衍生物用于糖尿病伤口愈合的用途
JP2022518288A (ja) 疼痛、炎症および／または自己免疫の処置または予防における使用のための化合物
CN101346144B (zh) 类固醇化合物衍生物在制备药物中的用途
EP3233825B1 (en) Diarylmethylidene piperidine derivatives and their use as delta opioid receptor agonists
AU2002325630A1 (en) Use of pregnane-diones or diols as neuropathic analgesic agents
CN110381934A (zh) 用于治疗睡眠呼吸障碍(sdb)的l-pag衍生物
JP2024511019A (ja) メラノサイト増殖促進剤および生存促進因子としての特異的炎症収束性メディエーター（ｓｐｍ）およびその使用

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C12 Rejection of a patent application after its publication
RJ01 Rejection of invention patent application after publication