RU2346690C2 - Применение прегнандионов или прегнандиолов в качестве невропатических анальгетических агентов - Google Patents

Применение прегнандионов или прегнандиолов в качестве невропатических анальгетических агентов Download PDF

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Publication number
RU2346690C2
RU2346690C2 RU2004109517/14A RU2004109517A RU2346690C2 RU 2346690 C2 RU2346690 C2 RU 2346690C2 RU 2004109517/14 A RU2004109517/14 A RU 2004109517/14A RU 2004109517 A RU2004109517 A RU 2004109517A RU 2346690 C2 RU2346690 C2 RU 2346690C2
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Russia
Prior art keywords
pain
rats
compounds
neuropathic pain
administered
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RU2004109517/14A
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English (en)
Russian (ru)
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RU2004109517A (ru
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Колин Стэнли ГУДЧАЙЛД (AU)
Колин Стэнли ГУДЧАЙЛД
Реймонд НЭДЕСОН (AU)
Реймонд НЭДЕСОН
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Монаш Юниверсити
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
RU2004109517/14A 2001-08-28 2002-08-28 Применение прегнандионов или прегнандиолов в качестве невропатических анальгетических агентов RU2346690C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPR7319 2001-08-28
AUPR7319A AUPR731901A0 (en) 2001-08-28 2001-08-28 Method of treatment

Publications (2)

Publication Number Publication Date
RU2004109517A RU2004109517A (ru) 2005-06-27
RU2346690C2 true RU2346690C2 (ru) 2009-02-20

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2004109517/14A RU2346690C2 (ru) 2001-08-28 2002-08-28 Применение прегнандионов или прегнандиолов в качестве невропатических анальгетических агентов

Country Status (10)

Country Link
US (2) US20050009796A1 (enExample)
EP (1) EP1450817A4 (enExample)
JP (1) JP2005504776A (enExample)
CN (2) CN101590062A (enExample)
AU (2) AUPR731901A0 (enExample)
BR (1) BR0212205A (enExample)
CA (1) CA2468466A1 (enExample)
MX (1) MXPA04001807A (enExample)
RU (1) RU2346690C2 (enExample)
WO (1) WO2003018027A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141650C1 (de) * 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
GB0324423D0 (en) * 2003-10-18 2003-11-19 Vernalis Cambridge Ltd Analgesia method
WO2006010085A1 (en) * 2004-07-09 2006-01-26 Roxro Pharma, Inc. Use of neurosteroids to treat neuropathic pain
RU2306930C1 (ru) * 2005-12-28 2007-09-27 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией лозартана и l-аргинина при l-name-индуцированном дефиците оксида азота
RU2306924C1 (ru) * 2005-12-28 2007-09-27 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией лозартана и резвератрола при l-name-индуцированном дефиците оксида азота
RU2302241C1 (ru) * 2005-12-28 2007-07-10 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией индапамида и резвератрола при l-name-индуцированном дефиците оксида азота
RU2296566C1 (ru) * 2005-12-28 2007-04-10 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией амлодипина и l-аргинина при l-name-индуцированном дефиците оксида азота
RU2306929C1 (ru) * 2005-12-28 2007-09-27 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией индапамида и l-аргинина при l-name-индуцированном дефиците оксида азота
KR20090125748A (ko) * 2007-04-02 2009-12-07 토요 보세키 가부시기가이샤 대상포진 후 신경통 치료용 정제 및 대상포진 후 신경통의 치료 방법
RU2364393C1 (ru) * 2008-03-19 2009-08-20 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции пикамилоном при l-name индуцированном дефиците оксида азота
US8815300B2 (en) 2008-08-29 2014-08-26 Coastal Biologic Solutions Composition and methods for relief of neuropathological pain

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2162554A1 (de) * 1970-12-17 1972-06-29 Glaxo Laboratories Ltd., Greenford, Middlesex (Grossbritannien) Anästhetische Zubereitung
GB1317184A (en) * 1969-06-20 1973-05-16 Glaxo Lab Ltd Steroid-containing pharmaceutical preparations
US6048848A (en) * 1996-08-23 2000-04-11 Monash University Use of pregnane-diones as analgesic agents
RU2169142C2 (ru) * 1996-04-03 2001-06-20 Лео Фармасьютикал Продактс Лтд. А/С, (Левенс Кемиске Фабрик Продукционсактиесельскаб) Аналоги витамина d, способ их получения, способы получения соединений

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888996A (en) * 1995-07-26 1999-03-30 Trustees Of Boston University Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity
EP0840612A1 (en) * 1995-07-24 1998-05-13 Trustees Of Boston University Inhibition of nmda receptor activity by pregnenolone sulfate derivatives
AUPN498095A0 (en) * 1995-08-23 1995-09-14 Goodchild, Colin Stanley Compounds and compositions
US6787530B1 (en) * 1996-08-23 2004-09-07 Monash University Use of pregnane-diones as analgesic agents
ATE425459T1 (de) * 1999-08-31 2009-03-15 Univ Boston Der effekt von steroiden auf ndma-rezeptoren beruht auf der zusammensetzung der untereinheiten
US20030027833A1 (en) * 2001-05-07 2003-02-06 Cleary Gary W. Compositions and delivery systems for administration of a local anesthetic agent

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1317184A (en) * 1969-06-20 1973-05-16 Glaxo Lab Ltd Steroid-containing pharmaceutical preparations
DE2162554A1 (de) * 1970-12-17 1972-06-29 Glaxo Laboratories Ltd., Greenford, Middlesex (Grossbritannien) Anästhetische Zubereitung
RU2169142C2 (ru) * 1996-04-03 2001-06-20 Лео Фармасьютикал Продактс Лтд. А/С, (Левенс Кемиске Фабрик Продукционсактиесельскаб) Аналоги витамина d, способ их получения, способы получения соединений
US6048848A (en) * 1996-08-23 2000-04-11 Monash University Use of pregnane-diones as analgesic agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
WINFREE C.J. et al., Analgesic effects of intrathecally-administered 3alpha-hydroxy-5alpha-pregnan-20-one in a rat mechanical visceral pain model, Life Sci. 1992; 50(14): 1007-12. *
КАРЛОВ В.А. Терапия нервных болезней. - М.: 1996, с.568-570, 573, 576, 601-608, 615-616. *

Also Published As

Publication number Publication date
US20050009796A1 (en) 2005-01-13
CN1549719A (zh) 2004-11-24
EP1450817A4 (en) 2009-02-25
CN101590062A (zh) 2009-12-02
CA2468466A1 (en) 2003-03-06
RU2004109517A (ru) 2005-06-27
EP1450817A1 (en) 2004-09-01
BR0212205A (pt) 2004-09-21
AU2008202729A1 (en) 2008-07-17
AUPR731901A0 (en) 2001-09-20
US20080227764A1 (en) 2008-09-18
JP2005504776A (ja) 2005-02-17
MXPA04001807A (es) 2005-03-07
WO2003018027A1 (en) 2003-03-06

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Effective date: 20100829