JP2005504776A - 神経因性鎮痛薬としてのプレグナン−ジオンまたはジオールの使用 - Google Patents

神経因性鎮痛薬としてのプレグナン−ジオンまたはジオールの使用 Download PDF

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JP2005504776A
JP2005504776A JP2003522545A JP2003522545A JP2005504776A JP 2005504776 A JP2005504776 A JP 2005504776A JP 2003522545 A JP2003522545 A JP 2003522545A JP 2003522545 A JP2003522545 A JP 2003522545A JP 2005504776 A JP2005504776 A JP 2005504776A
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alkyl
alkanoyl
alkenyl
formula
compound
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JP2003522545A
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Japanese (ja)
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JP2005504776A5 (enExample
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グッドチャイルド，コリン，スタンレー
ナデソン，レイモンド
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Publication of JP2005504776A publication Critical patent/JP2005504776A/ja
Publication of JP2005504776A5 publication Critical patent/JP2005504776A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

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  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
JP2003522545A 2001-08-28 2002-08-28 神経因性鎮痛薬としてのプレグナン−ジオンまたはジオールの使用 Pending JP2005504776A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPR7319A AUPR731901A0 (en) 2001-08-28 2001-08-28 Method of treatment
PCT/AU2002/001144 WO2003018027A1 (en) 2001-08-28 2002-08-28 Use of pregnane-diones or diols as neuropathic analgesic agents

Publications (2)

Publication Number Publication Date
JP2005504776A true JP2005504776A (ja) 2005-02-17
JP2005504776A5 JP2005504776A5 (enExample) 2006-01-05

Family

ID=3831271

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003522545A Pending JP2005504776A (ja) 2001-08-28 2002-08-28 神経因性鎮痛薬としてのプレグナン−ジオンまたはジオールの使用

Country Status (10)

Country Link
US (2) US20050009796A1 (enExample)
EP (1) EP1450817A4 (enExample)
JP (1) JP2005504776A (enExample)
CN (2) CN101590062A (enExample)
AU (2) AUPR731901A0 (enExample)
BR (1) BR0212205A (enExample)
CA (1) CA2468466A1 (enExample)
MX (1) MXPA04001807A (enExample)
RU (1) RU2346690C2 (enExample)
WO (1) WO2003018027A1 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141650C1 (de) * 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
GB0324423D0 (en) * 2003-10-18 2003-11-19 Vernalis Cambridge Ltd Analgesia method
WO2006010085A1 (en) * 2004-07-09 2006-01-26 Roxro Pharma, Inc. Use of neurosteroids to treat neuropathic pain
RU2306930C1 (ru) * 2005-12-28 2007-09-27 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией лозартана и l-аргинина при l-name-индуцированном дефиците оксида азота
RU2306924C1 (ru) * 2005-12-28 2007-09-27 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией лозартана и резвератрола при l-name-индуцированном дефиците оксида азота
RU2302241C1 (ru) * 2005-12-28 2007-07-10 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией индапамида и резвератрола при l-name-индуцированном дефиците оксида азота
RU2296566C1 (ru) * 2005-12-28 2007-04-10 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией амлодипина и l-аргинина при l-name-индуцированном дефиците оксида азота
RU2306929C1 (ru) * 2005-12-28 2007-09-27 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции комбинацией индапамида и l-аргинина при l-name-индуцированном дефиците оксида азота
KR20090125748A (ko) * 2007-04-02 2009-12-07 토요 보세키 가부시기가이샤 대상포진 후 신경통 치료용 정제 및 대상포진 후 신경통의 치료 방법
RU2364393C1 (ru) * 2008-03-19 2009-08-20 Михаил Владимирович Покровский Способ коррекции эндотелиальной дисфункции пикамилоном при l-name индуцированном дефиците оксида азота
US8815300B2 (en) 2008-08-29 2014-08-26 Coastal Biologic Solutions Composition and methods for relief of neuropathological pain

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997007807A1 (en) * 1995-08-23 1997-03-06 Colin Stanley Goodchild New use of pregnane-diones as analgesic agents
JPH11509844A (ja) * 1995-07-24 1999-08-31 トラスティーズ オブ ボストン ユニバーシティー プレグネノロンサルフェート誘導体によるｎｍｄａレセプター活性の抑制
US6048848A (en) * 1996-08-23 2000-04-11 Monash University Use of pregnane-diones as analgesic agents
WO2001016601A1 (en) * 1999-08-31 2001-03-08 Trustees Of Boston University Effect of steroids on nmda receptors depends on subunit composition

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1317184A (en) * 1969-06-20 1973-05-16 Glaxo Lab Ltd Steroid-containing pharmaceutical preparations
GB1373913A (en) * 1970-12-17 1974-11-13 Glaxo Lab Ltd Pharmaceutical compositions
US5888996A (en) * 1995-07-26 1999-03-30 Trustees Of Boston University Inhibition of NMDA receptor activity and modulation of glutamate-mediated synaptic activity
GB9607034D0 (en) * 1996-04-03 1996-06-05 Leo Pharm Prod Ltd Chemical compounds
US6787530B1 (en) * 1996-08-23 2004-09-07 Monash University Use of pregnane-diones as analgesic agents
US20030027833A1 (en) * 2001-05-07 2003-02-06 Cleary Gary W. Compositions and delivery systems for administration of a local anesthetic agent

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11509844A (ja) * 1995-07-24 1999-08-31 トラスティーズ オブ ボストン ユニバーシティー プレグネノロンサルフェート誘導体によるｎｍｄａレセプター活性の抑制
WO1997007807A1 (en) * 1995-08-23 1997-03-06 Colin Stanley Goodchild New use of pregnane-diones as analgesic agents
US6048848A (en) * 1996-08-23 2000-04-11 Monash University Use of pregnane-diones as analgesic agents
WO2001016601A1 (en) * 1999-08-31 2001-03-08 Trustees Of Boston University Effect of steroids on nmda receptors depends on subunit composition

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6009025165, ＷＩＮＦＲＥＥ， Ｃ． Ｊ．, "Ａｎａｌｇｅｓｉｃ ｅｆｆｅｃｔｓ ｏｆ ｉｎｔｒａｔｈｅｃａｌｌｙ−ａｄｍｉｎｉｓｔｅｒｅｄ ３α−ｈｙｄｒｏｘｙ−５α−ｐｒｅｇｎａｎ−２０−ｏｎｅ ｉｎ ａ ｒａｔ ｍｅｃｈａｎｉｃａｌ ｖ", Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ, 1992, ５０（１４）, ｐ． １００７−１０１２ *
JPN6009025166, ＮＡＤＥＳＯＮ， Ｒ．, "Ａｎｔｉｎｏｃｉｃｅｐｔｉｖｅ ｐｒｏｐｅｒｔｉｅｓ ｏｆ ｎｅｕｒｏｓｔｅｒｏｉｄｓ ＩＩ． Ｅｘｐｅｒｉｍｅｎｔｓ ｗｉｔｈ Ｓａｆｆａｎ ａｎｄ ｉｔｓ ｃｏｍｐｏｎｅｎｔｓ ａｌｐｈａｘａｌｏ", Ｐａｉｎ, 2000, ８８（１）, ｐ． ３１−３９ *
JPN6009025168, 山本達郎, "ＮＭＤＡレセプタと疼痛", 麻酔, 1996, ４５（１１）, ｐ． １３１２−１３１８ *

Also Published As

Publication number Publication date
US20050009796A1 (en) 2005-01-13
CN1549719A (zh) 2004-11-24
EP1450817A4 (en) 2009-02-25
CN101590062A (zh) 2009-12-02
CA2468466A1 (en) 2003-03-06
RU2004109517A (ru) 2005-06-27
RU2346690C2 (ru) 2009-02-20
EP1450817A1 (en) 2004-09-01
BR0212205A (pt) 2004-09-21
AU2008202729A1 (en) 2008-07-17
AUPR731901A0 (en) 2001-09-20
US20080227764A1 (en) 2008-09-18
MXPA04001807A (es) 2005-03-07
WO2003018027A1 (en) 2003-03-06

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