CN1544071A - Children cough and asthma treating Chinese traditional medicine and its preparation - Google Patents
Children cough and asthma treating Chinese traditional medicine and its preparation Download PDFInfo
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- CN1544071A CN1544071A CNA2004100382479A CN200410038247A CN1544071A CN 1544071 A CN1544071 A CN 1544071A CN A2004100382479 A CNA2004100382479 A CN A2004100382479A CN 200410038247 A CN200410038247 A CN 200410038247A CN 1544071 A CN1544071 A CN 1544071A
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Abstract
The present invention relates to a Chinese traditional medicine used for treating children cough and asthma and method for making same. Cough and asthma disease is children's common disease clinically and occurs more often, and there is no rapid and effective medicine for treating it up to the present. Since the children cough and asthma is urgent, high in morbidity, and threat children health even lives, the research and development of medicines for children cough and asthma has clinical operation significance to serve for patients. The composing prescription in accordance with the present invention consists of 15 Chinese herbal medicine components, wherein Chinese ephedra and gypsum interact mutually to balance cold and heat on one hand and to exhibit an assorting effect due to its being sting and sweet on the other hand, capable of curing the exterior syndromes and relaxing the haggis Qi, balancing the Yin and the Yang. Thus, the present invention possesses the effects of reducing fever, promoting the dispersing function of the lung, resolving phlegm and cough, relieving asthma and the like; and is characterized by its rapid acting, remarkable curative effect, convenience to carry and admit and the like at the same time.
Description
One, technology neck city:
The present invention relates to a kind of Chinese medicine for the treatment of infantile asthma and preparation method thereof.Particularly have one group of Chinese medicine composition of unique Chinese medicine curative effect for treatment fever of children, cough, asthma etc., specifically describing is to be raw material with the Chinese herbal medicine, extracts the pure compound Chinese medicinal preparation that processing forms through sophisticated equipment and its preparation process processing.
Two, background technology:
Cough is a common disease in children clinically, and multiple disease does not still have rapidly effectively medicine so far.Because its oncoming force is anxious, sickness rate height, the serious health that is threatening the child, even threat to life.Therefore, the medication of research and development infantile asthma is served extensive patients and is had clinical realistic meaning.
Three, summary of the invention:
The object of the present invention is to provide a kind of reducing heat and dispersing lung-QI that has, preventing phlegm from forming and stopping coughing, the lowering the adverse QI to relieve asthma effect is used for the treatment of fever of children, cough, Chinese medicine of asthma and preparation method thereof.
For achieving the above object, the technical solution used in the present invention is:
A kind of Chinese medicine for the treatment of infantile asthma, its special character is: the Chinese medicine of described treatment infantile asthma is the medicament of being made by following materials of weight proportions:
Herba Ephedrae 20-40 part Bulbus Fritillariae Cirrhosae 20-40 part Semen Armeniacae Amarum 40-60 part
Radix Scutellariae 40-60 part Concretio Silicea Bambusae 40-60 part Fructus Perillae 50-70 part
Bombyx Batryticatus 50-70 part Fructus Crataegi 50-70 part Semen Raphani 50-70 part
Gypsum Fibrosum 90-110 part Herba Houttuyniae 110-130 part Herba Asari 3-6 part
Folium Camelliae sinensis 4-6 part Radix Glycyrrhizae 20-40 part Radix Platycodonis 40-60 part
The Chinese medicine of above-mentioned treatment infantile asthma is the medicament of being made by following materials of weight proportions:
50 parts of 30 portions of Semen Armeniacae Amarums of 30 parts of Bulbus Fritillariae Cirrhosaes of Herba Ephedrae
60 parts of 50 parts of Fructus Perillaes of 50 parts of Concretio Silicea Bambusaes of Radix Scutellariae
60 parts of 60 parts of Semen Raphanis of 60 portions of Fructus Crataegis of Bombyx Batryticatus
5 parts of 120 parts of Herba Asaris of 100 parts of Herba Houttuyniae of Gypsum Fibrosum
50 parts of 30 parts of Radix Platycodoniss of 5 portions of Radix Glycyrrhizaes of Folium Camelliae sinensis
Above-mentioned medicament is the above a dosage form of any pharmaceutics.
Above-mentioned dosage form is granule, tablet, capsule.
Its preparation process of above-mentioned granule is as follows:
(1), with Semen Armeniacae Amarum, Fructus Perillae, Bombyx Batryticatus, Fructus Crataegi, Semen Raphani 5 flavor Chinese medicines, fry with slow fire respectively, after concocting, standby;
(2), get Bulbus Fritillariae Cirrhosae powder and be broken into 80-120 purpose fine powder, standby;
(3), with Herba Asari, Herba Houttuyniae extracts volatile oil, aqueous solution after distillation device is in addition preserved, 12 flavors such as medicinal residues and all the other Herba Ephedraes decoct with water secondary, each 1.5 hours, collecting decoction filtered, filtrate and above-mentioned aqueous solution merge, be concentrated into temperature in the time of 85-90 ℃, relative density is the clear paste of 1.38-1.40;
(4), 1 part of qinghuo reagent, with 2.2 parts of sucrose, 0.5 part in dextrin adds the Bulbus Fritillariae Cirrhosae fine powder, mixing is made granule, drying, spray adds Herba Asari, Herba Houttuyniae volatile oil, mixing promptly gets granular preparation.
Its preparation process of above-mentioned tablet is as follows:
(1), with Semen Armeniacae Amarum, Fructus Perillae, Bombyx Batryticatus, Fructus Crataegi, Semen Raphani 5 flavor Chinese medicines, fry with slow fire respectively, after concocting, standby;
(2), get Bulbus Fritillariae Cirrhosae powder and be broken into 80-120 purpose fine powder, standby;
(3), with Herba Asari, Herba Houttuyniae extracts volatile oil, the aqueous solution after distillation device is in addition preserved, 12 flavors such as medicinal residues and all the other Herba Ephedraes decoct with water secondary, and each 1.5 hours, collecting decoction, filter, filtrate and above-mentioned aqueous solution merge, and adjust pure content to 65%, precipitate with ethanol, left standstill 48 hours, after reclaiming ethanol, with its be concentrated into temperature 85-90 ℃ the time, relative density is the clear paste of 1.08-1.10, spray drying;
(4), with the Bulbus Fritillariae Cirrhosae powder mixing in cream powder in the step (3) and the step (2), add adjuvant, spray granulation, compacting in flakes, the bag film-coat, promptly.
Its preparation process of above-mentioned capsule is as follows:
(1), with Semen Armeniacae Amarum, Fructus Perillae, Bombyx Batryticatus, Fructus Crataegi, Semen Raphani 5 flavor Chinese medicines, fry with slow fire respectively, after concocting, standby;
(2), get Bulbus Fritillariae Cirrhosae powder and be broken into 80-120 purpose fine powder, standby;
(3), with Herba Asari, Herba Houttuyniae extracts volatile oil, the aqueous solution after distillation device is in addition preserved, 12 flavors such as medicinal residues and all the other Herba Ephedraes decoct with water secondary, and each 1.5 hours, collecting decoction, filter, filtrate and above-mentioned aqueous solution merge, and adjust pure content to 65%, precipitate with ethanol, left standstill 48 hours, after reclaiming ethanol, with its be concentrated into temperature 85-90 ℃ the time, relative density is the clear paste of 1.08-1.10, spray drying;
(4), with the Bulbus Fritillariae Cirrhosae powder mixing in cream powder in the step (3) and the step (2), add adjuvant, spray granulation incapsulates, promptly.
Its preparation process of above-mentioned soft capsule is as follows:
(1), with Semen Armeniacae Amarum, Fructus Perillae, Bombyx Batryticatus, Fructus Crataegi, Semen Raphani 5 flavor Chinese medicines, fry with slow fire respectively, after concocting, standby;
(2), get Bulbus Fritillariae Cirrhosae powder and be broken into 80-120 purpose fine powder, standby;
(3), with Herba Asari, Herba Houttuyniae extracts volatile oil, the aqueous solution after distillation device is in addition preserved, 12 flavors such as medicinal residues and all the other Herba Ephedraes decoct with water secondary, and 2 hours each time, every secondary 1 hour, collecting decoction filters, and filtrate and above-mentioned aqueous solution merge, adjust pure content to 85%, precipitate with ethanol left standstill 48 hours, behind the recovery ethanol, with its be concentrated into temperature 60 ℃ the time, relative density is the clear paste of 1.30-1.32, drying under reduced pressure;
(4), with the Bulbus Fritillariae Cirrhosae powder mixing in cream powder in the step (3) and the step (2);
(5), adding volatile oil, salad oil are mixed into the suspension of 50-55% again, make soft capsule.
The present invention is with respect to prior art, and its advantage is as follows:
The present invention has reducing heat and dispersing lung-QI, preventing phlegm from forming and stopping coughing, and the lowering the adverse QI to relieve asthma effect is applicable to fever of children, cough, symptoms such as asthma.Its effect rapidly, curative effect is obvious, is easy to carry and takes.
Four, specific embodiment:
Infantile asthma granule of the present invention is on the basis of MAXINGSHIGAN TANG, controls principle according to the differential diagnosis in tcm opinion, under the prerequisite on utilization theory of Chinese medical science basis, through the scientific formula screening, uses Chinese crude drug and takes under the prerequisite of science extraction process, refining processing.This side is the characteristics of infantile asthma card, summarizes with " heat, cough, expectorant, breathe heavily " four diseases, pointed out the cause of disease and sick to have illustrated pathogenesis and pathology, has reducing heat and dispersing lung-QI, relieving cough and resolving phlegm, lowering the adverse QI to relieve asthma effect.Have effect simultaneously rapidly, curative effect is obvious, and characteristics such as be easy to carry and take.
Respectively the distinguish the flavor of property of medicine of medicine of prescription of the present invention is:
1, Herba Ephedrae: be the herb stem of Ephedraceae plant Herba Ephedrae, epheday intermedia etc.
Nature and flavor: hot, little hardship, temperature.Return lung, urinary bladder channel.
Performance characteristics: this product quality lightly floats, and suffering warm in nature is loose, and goes into lung, and urinary bladder channel focuses on lung qi dispersing.The external enwergy loosing the interspaces of skin and muscles, saturating hair key, dispersing wind and cold, with relieving the exterior syndrome by diaphoresis, the efficacy of a drug is stronger, the internal energy lung qi dispersing gas of opening, QI flow promoting and relievining asthma.In addition, by lung qi dispersing, again can regulating fluid apssage and inducing diuresis to remove edema.
2, Bulbus Fritillariae Cirrhosae: dark violet for the liliaceous plant Bulbus Fritillariae Cirrhosae, Bulbus Fritillariae Uninbracteatae etc. descend bulb dryly.
Nature and flavor: sweet, bitter, be slightly cold.Return lung, heart channel.
Performance characteristics: this product is cool in nature and sweet, is clear and rich product, can removing heat from the lung and dissipating phlegm, again can nourishing the lung to arrest cough, and be the dryness of the lung, the many usefulness of cough due to consumptive disease also have the merit of heat clearing away eliminating stagnation.
3, Semen Armeniacae Amarum (stir-fry): be the rosaceous plant Prunus armeniaca L.var.ansu Maxim., the dry mature seed of distant Fructus Pruni and Fructus Pruni.
Nature and flavor: bitter, tepor, slightly poisonous.Return lung, large intestine channel.
Performance characteristics: bitter gentle the falling of this product, go into lung, large intestine channel.On can fall lung qi and breathe heavily with cough-relieving, following can intestine moistening dry, and the merit of lung qi dispersing of in falling lung qi, holding concurrently with logical stool, demonstrate,prove so can be used for multiple cough with asthma.
4, Radix Scutellariae: be the dry root of labiate Radix Scutellariae.
Nature and flavor: bitter, cold.Return lung, gallbladder, stomach, large intestine channel.
Performance characteristics: this product bitter cold is let out dampness clearly, main lung and the large intestine, double stomach and the liver and gall of returning of returning.Effect is part of the body cavity above the diaphragm housing the heart and lungs lung and large intestine relatively, and the fire of kind lung heat clearing and large intestine except that last damp-heat in middle-JIAO, is doublely gone into blood system and removing heat from blood, heat clearing away and antiabortive.
5, Concretio Silicea Bambusae: the block that condenses and form for the juice drying in the stalks such as grass Chinese textile bamboo.
Nature and flavor: sweet, cold.Effect: removing heat-phlegm, arresting convulsion clears away heart-fire.
6, Fructus Perillae (stir-fry): be the dry mature fruit of labiate Folium Perillae.
Nature and flavor: hot, warm.Return lung, large intestine channel.
Performance characteristics: this product acrid in the mouth is warm in nature, goes into lung, large intestine channel.Be good at the sending down the abnormal ascending QI expectorant, relieving cough and asthma is again because of matter profit loosening bowel to relieve constipation.
7, Bombyx Batryticatus (stir-fry): for the larva of Bombycidae animal silkworm before not weaving silk, because of infecting the muscardine lethal rigid polypide that falls ill.
Nature and flavor: salty, hot, flat.
Performance characteristics: this moral character is flat, double can reduce phlegm, and twitches with treating the liver wind or the hot infantile convulsion of expectorant, and rubella is treated and swollen, cards such as erysipelas.
8, Fructus Crataegi (stir-fry): the dry mature fruit of rosaceous plant Fructus Pyri Pashiae or Fructus Crataegi.
Nature and flavor: sour, sweet, tepor.Return spleen, stomach, Liver Channel.
Performance characteristics: this product acid is sweet, tepor is not hot, and promoting digestion and removing stagnation power is stronger, and the outstanding kind digestion that promotes that meat is long-pending is for controlling the long-pending key medicine of greasy meat.
9, Semen Raphani (stir-fry): be the dry mature seed of crucifer Radix Raphani.
Nature and flavor: hot, sweet, flat.Return spleen, stomach, lung meridian.
Performance characteristics: the hot sweet property of this product is flat and the efficacy of a drug is strong, both has been good at helping digestion removing expanding, and it is the most suitable to control dyspeptic abdominal distention.Be longer than the sending down the abnormal ascending QI expectorant again, the cough with asthma of controlling expectorant birth heap soil or fertilizer over and around the roots Sheng is also good.
10, Gypsum Fibrosum: be Sulfates mineral anhydrite family Gypsum Fibrosum, the main hydrous calcium sulfate that contains.
Nature and flavor: hot, sweet, Great Cold.Attach to the lung and stomach meridians.
Performance characteristics: give birth to letting out clearly and reach thoroughly and all in this product hot sweet Great Cold, both kind clear lose heart divide excess-heat and lung excess of the stomach fire, expelling pathogenic factors from muscles is diathermanous again, heat goes to the then tired Tianjin of removing only to give birth to yearningly, for controlling the key medicine of edema caused by disorder of QI hyperpyrexia and lung excess of the stomach fire.
11, Herba Houttuyniae: be the herb of Saururaceae plant Ji Lay.
Nature and flavor: hot, be slightly cold.Return lung meridian.
Performance characteristics: this product is hot cold, and removing summer-heat reaches thoroughly, goes into lung meridian, kind removing summer-heat lung meridian pathogenic heat, and merit master's heat-clearing and toxic substances removing, removing pus and relieving carbuncle is for controlling this key medicine of lung abscess.Double again tonneau can inducing diuresis for treating stranguria syndrome.
12, Herba Asari: be the dry herb of aristolochiaceae plant Herba Asari or Hua Xin etc.
Nature and flavor: hot, temperature, slightly poisonous.Return lung, kidney channel.
Performance characteristics: the hot temperature of this product is walked to scurry, and aroma is dense, goes into the lung kidney channel.Both kindly dispel the wind, dispersing cold for relieving pain and a surname's clearing the nasal passage, be affected by the cold for controlling, plant the good medicine of pain card and the headache of nasal sinusitis nasal obstruction more than the rheumatism.The lung cold of again can temperature loosing, the drink that reduces phlegm is for controlling the key medicine that cold fluid-retention lies prostrate lung.
13, Folium Camelliae sinensis: the green dish of being processed into by fresh leaf of Camelliae sinensis, black tea, Folium Camelliae sinensis, scented tea etc.
Performance characteristics: have the inherent color of this tea, promoting the production of body fluid to quench thirst refreshment.
14, Radix Glycyrrhizae: be the dry root and rhizome of glycyrrhizic legume.
Nature and flavor: sweet, flat.GUIXIN, lung, spleen, stomach warp.
Performance characteristics: the flat sweet in the mouth of this moral character, can the QI invigorating invigorating middle warmer, again can relieving spasm to stop pain, relax the property of medicine, can also lung moistening eliminate the phlegm and relieving cough and asthma.
15, Radix Platycodonis: be the dry root of campanulaceae Platycodon grandiflouorum.
Nature and flavor: bitter, hot, flat.Return lung meridian.
Performance characteristics: the hot hardship of loosing of this product is let out, and the property of medicine is gentle, and the light weight come-up is specially walked lung meridian.Kind open lung qi dispersing gas and sore-throat relieving eliminates the phlegm, and can evacuation of pus and control lung abscess.
Prescription of the present invention is made up of 15 flavor Chinese herbal medicine compositions, square epheday intermedia and Gypsum Fibrosum mutually 5, and cold and heat are made mutually on the one hand, and Xin Gan tunable again can be controlled exterior syndrome and the double lung qi that leads on the other hand, and the pathologic pathogenic heat are gone, and the coordination of physiological negative and positive; The bitter temperature of Semen Armeniacae Amarum, hardship then can be fallen, the Wen Zeneng liter, fall with bitter temperature, and coordinating the actions of various ingredients in a prescription, its key is to solve heat, cough, expectorant, breathe heavily four diseases.The power that adds Herba Houttuyniae, Concretio Silicea Bambusae, Bulbus Fritillariae Cirrhosae, Bombyx Batryticatus, removing heat-phlegm is very male, and simultaneously using both cold and hot drugs more has Herba Asari simply, and it is warm in nature, helps Herba Ephedrae cold to go in the lung, can prevent the fraud of the medicine impairing the lung of bitter cold again, really can the pause and transition in rhythm or melody patient's condition.
The present invention has reducing heat and dispersing lung-QI, preventing phlegm from forming and stopping coughing, and lowering the adverse QI to relieve asthma is used for fever of children, cough, symptoms such as asthma.
Infantile asthma granule of the present invention Xian Medical Univ pharmacodynamics toxicological experiment proves: this medicine can suppress the mouse cough reflection that ammonia causes through mouse test; Increase the phenol red excretion amount of mice trachea; The guinea pig bronchial spasm there is antagonism; Escherichia coli endotoxin is caused rabbit fever models have the effect of the body temperature of reduction.Result of the test proof infantile asthma granule has cough-relieving, eliminates the phlegm, relievings asthma, refrigeration function.Prove that by acute and chronic toxicity test infantile asthma granule maximum dosage-feeding is 134g crude drug/kg (106.6 times of suitable people's maximal dose 0.6g/kg according to the weight).In the continuous prolonged application of this dosage the rat observation is not caused the overt toxicity reaction, belong to safety treatment medicine.
In order to show the present invention to cough with asthma, generate heat, the clinical efficacy of dispelling and talking is enumerated some clinical datas and case below.
Therapeutic outcome
Table one
| Observation unit | Total routine number | Recovery from illness | Effectively | Invalid | Total effective rate | ||||||
| The example number | ??％ | The example number | ???％ | The example number | ????％ | ????％ | |||||
| Xi'an institute of traditional Chinese medicine department of pediatrics | ?55 | ???32 | ??58.2 | ????21 | ???38.1 | ??2 | ????3.7 | ????96.3 | |||
| Xi'an maternity and child care center department of pediatrics | ?30 | ???8 | ??26.6 | ????21 | ???70.1 | ??1 | ????3.3 | ????96.7 | |||
| Xi'an children's hospital internal medicine | ?30 | ???22 | ??73.3 | ????7 | ???23.3 | ??1 | ????3.4 | ????96.6 | |||
| Xincheng District institute of traditional Chinese medicine department of pediatrics | ?175 | ???153 | ??87.4 | ????18 | ???10.3 | ??4 | ????2.3 | ????96.7 | |||
| Xincheng District institute of traditional Chinese medicine internal medicine | ?30 | ???22 | ??73.5 | ????5 | ???16.7 | ??3 | ????10 | ????90 | |||
| Amount to | ?320 | ???237 | ??74 | ????72 | ???22.5 | ??11 | ????3.5 | ????96.5 | |||
It seems from table one:
In 320 examples of observing, 237 examples of fully recovering account for 74%; Effective 72 examples account for 22.5%; Invalid 11 examples account for 3.5%; Total effective rate is 96.5%.
Child, adult be statistical table respectively
Table two 290 routine child's curative effect statistical tables
| Total routine number | Cure | Effectively | Invalid | Total effective rate | |||
| The example number | ????％ | The example number | ???％ | The example number | ???％ | ????％ | |
| ??290 | ??215 | ????74.2 | ??67 | ???23.1 | ??8 | ???2.7 | ????97.3 |
30 example adult curative effect statistical tables
Table three
| Total routine number | Cure | Effectively | Invalid | Total effective rate | |||
| The example number | ????％ | The example number | ???％ | The example number | ???％ | ????％ | |
| ??30 | ??22 | ????73.5 | ?5 | ???16.7 | ??3 | ???10 | ????90 |
It seems that from table two, table three child's total effective rate is 97.3%, adult's total effective rate is 90%.
Period appears in the cardinal symptom curative effect
Table four
| Symptom | Case load | Period appears in the cardinal symptom curative effect | ||
| 1-3 days | 4-5 days | More than 5 days | ||
| Heat | ????104 | ????88 | ????16 | ????0 |
| Cough | ????250 | ????129 | ????116 | ????5 |
| Breathe heavily | ????68 | ????56 | ????11 | ????1 |
One of model case
Open X, the woman,
Year, infant heating, cough was examined over three days, symptoms including cough, watery nasal discharge, gurgling with sputum, breast reduces, two is just normal, indagation body temperature 38C, the little Huang of the red tongue of words and being bored with, swallow red, the fingerprint purple, two pulmonary respiration sounds are thick.Accompany a little rale.Disease belongs to the exterior tightened by exogenous pathogens, lung qi closing.Give oral infantile asthma granule, each bag three times on the one, is taken medicine and was followed up a case by regular visits to recovery from illness in four days.
Two of model case
Zhu X, the man,
Year, infant cough, rale, the time heating arranged, once in outer court's bronchopneumonia with treatments such as erythromycin, imitate, require Chinese traditional treatment.It is poor that its mother states diet, sleep disorder, and the nocturnal cough is heavy, and the abundant expectoration tachypnea hopes its complexion owe China, and spirit is also poor, the little fan of the wing of nose, wheezing sound in the throat, sound, the dry lip red tongue with yellowish and greasy fur, fingerprint is livid purple, two lungs have the rale sound, and there is a little wet ring in the north, and disease is a phlegm-heat closed lung, clothes infantile asthma granule, once
One bag, day recovery from illness in 4 times 4 days.
Three of model case
Open XX, the man, 3 years old, infant was coughed and has been had a surplus February, increases the weight of to cough a week abundant expectoration, through invalid with antibiotics, disease is seen red tongue, and tongue is thin in vain, and thready pulse is tight, and two pulmonary respiration sounds are coarse, and the rale sound is arranged, disease belongs to wind-heat invading the lung, clothes infantile asthma granule, and each bag three times on the one, is followed up a case by regular visits to recovery from illness after the week.
Four of model case
Cao XX, the woman, 8 years old, the infant cough, surplus in the of 14 go to a doctor in a day back, and the first quarter moon cause is suffered from cold and is caused cough, watery nasal discharge, dyspnea with rapid and short breath then, heating was once arrived his institute's prescription on individual diagnosis and was the Zhi Suoguan inflammation, and clothes Western medicine heat is moved back asthma and is subtracted slightly, but cough is more than, has expectorant to be difficult for bringing up, and coughs night heavily, is paroxysmal, companion's vomiting sputum or food.Receive can, big dry stool, urine is many.Disease see spirit still can, watery nasal discharge is swallowed red not obviously, colour of the tongue is little red, and is greasy in the yellow fur, the fingerprint purple.Disease belongs to the cough due to common cold, in have damp and hot, clothes infantile asthma granule, each three guarantees, three times on the one, i.e. recovery from illness after the week.
Embodiment 1:
Herba Ephedrae 30g Bulbus Fritillariae Cirrhosae 30g Semen Armeniacae Amarum (stir-fry) 50g
Radix Scutellariae 50g Concretio Silicea Bambusae 50g Fructus Perillae (stir-fry) 60g
Bombyx Batryticatus (stir-fry) 60g Fructus Crataegi (stir-fry) 60g Semen Raphani (stir-fry) 60g
Gypsum Fibrosum 100g Herba Houttuyniae 120g Herba Asari 5g
Folium Camelliae sinensis 5g Radix Glycyrrhizae 30g Radix Platycodonis 50g
Production technology preparation method following steps:
With above 15 flavors, by concocting, prescription is got Bulbus Fritillariae Cirrhosae powder and is broken into fine powder after handling; Herba Asari, Herba Houttuyniae extracts volatile oil, and the aqueous solution after distillation device is in addition preserved, 12 flavors such as medicinal residues and all the other Herba Ephedraes decoct with water secondary, each 1.5 hours, collecting decoction filtered, filtrate and above-mentioned aqueous solution merge, being concentrated into relative density is 1.38-1.40 (85-90 ℃) clear paste, and 1 part of qinghuo reagent is with 2.2 parts of sucrose, 0.5 part in dextrin, add the Bulbus Fritillariae Cirrhosae fine powder, mixing is made granule, dry, spray adds Herba Asari, Herba Houttuyniae volatile oil, mixing, under the air cleaning aseptic condition, making plastic-aluminum is that 6 children's that restrain a bag breathe heavily finished granule for packed every bag.
Embodiment 2:
Herba Ephedrae 20g Bulbus Fritillariae Cirrhosae 20g Semen Armeniacae Amarum (stir-fry) 40g
Radix Scutellariae 40g Concretio Silicea Bambusae 50g Fructus Perillae (stir-fry) 60g
Bombyx Batryticatus (stir-fry) 50g Fructus Crataegi (stir-fry) 50g Semen Raphani (stir-fry) 50g
Gypsum Fibrosum 90g Herba Houttuyniae 110g Herba Asari 3g
Folium Camelliae sinensis 4g Radix Glycyrrhizae 20g Radix Platycodonis 40g
Its preparation process of above-mentioned tablet is as follows:
(1), with Semen Armeniacae Amarum, Fructus Perillae, Bombyx Batryticatus, Fructus Crataegi, Semen Raphani 5 flavor Chinese medicines, fry with slow fire respectively, after concocting, standby;
(2), get Bulbus Fritillariae Cirrhosae powder and be broken into 80-120 purpose fine powder, standby;
(3), with Herba Asari, Herba Houttuyniae extracts volatile oil, the aqueous solution after distillation device is in addition preserved, 12 flavors such as medicinal residues and all the other Herba Ephedraes decoct with water secondary, and each 1.5 hours, collecting decoction, filter, filtrate and above-mentioned aqueous solution merge, and adjust pure content to 65%, precipitate with ethanol, left standstill 48 hours, after reclaiming ethanol, with its be concentrated into temperature 85-90 ℃ the time, relative density is the clear paste of 1.08-1.10, spray drying;
(4), with the Bulbus Fritillariae Cirrhosae powder mixing in cream powder in the step (3) and the step (2), add adjuvant, spray granulation, compacting in flakes, the bag film-coat, promptly.
Embodiment 3:
Herba Ephedrae 40g Bulbus Fritillariae Cirrhosae 40g Semen Armeniacae Amarum (stir-fry) 60g
Radix Scutellariae 60g Concretio Silicea Bambusae 60g Fructus Perillae (stir-fry) 70g
Bombyx Batryticatus (stir-fry) 70g Fructus Crataegi (stir-fry) 70g Semen Raphani (stir-fry) 70g
Gypsum Fibrosum 110g Herba Houttuyniae 130g Herba Asari 6g
Folium Camelliae sinensis 6g Radix Glycyrrhizae 40g Radix Platycodonis 60g
Its preparation process of above-mentioned capsule is as follows:
(1), with Semen Armeniacae Amarum, Fructus Perillae, Bombyx Batryticatus, Fructus Crataegi, Semen Raphani 5 flavor Chinese medicines, fry with slow fire respectively, after concocting, standby;
(2), get Bulbus Fritillariae Cirrhosae powder and be broken into 80-120 purpose fine powder, standby;
(3), with Herba Asari, Herba Houttuyniae extracts volatile oil, the aqueous solution after distillation device is in addition preserved, 12 flavors such as medicinal residues and all the other Herba Ephedraes decoct with water secondary, and each 1.5 hours, collecting decoction, filter, filtrate and above-mentioned aqueous solution merge, and adjust pure content to 65%, precipitate with ethanol, left standstill 48 hours, after reclaiming ethanol, with its be concentrated into temperature 85-90 ℃ the time, relative density is the clear paste of 1.08-1.10, spray drying;
(4), with the Bulbus Fritillariae Cirrhosae powder mixing in cream powder in the step (3) and the step (2), add adjuvant, spray granulation incapsulates, promptly.
Embodiment 4:
Herba Ephedrae 120g Bulbus Fritillariae Cirrhosae 120g Radix Scutellariae 200g Semen Armeniacae Amarum (stir-fry) 200g
Yellow 200g Herba Asari 20g Fructus Perillae (stir-fry) 240g of Gypsum Fibrosum Zhu 400g
Folium Camelliae sinensis 20g Herba Houttuyniae 240g Radix Glycyrrhizae 120g Semen Raphani (stir-fry) 240g
Radix Platycodonis 200g Fructus Crataegi (stir-fry) 240g Bombyx Batryticatus (stir-fry) 240g
Its preparation process of above-mentioned soft capsule is as follows:
(1), with Semen Armeniacae Amarum, Fructus Perillae, Bombyx Batryticatus, Fructus Crataegi, Semen Raphani 5 flavor Chinese medicines, fry with slow fire respectively, after concocting, standby;
(2), get Bulbus Fritillariae Cirrhosae powder and be broken into 80-120 purpose fine powder, standby;
(3), with Herba Asari, Herba Houttuyniae extracts volatile oil, the aqueous solution after distillation device is in addition preserved, 12 flavors such as medicinal residues and all the other Herba Ephedraes decoct with water secondary, and 2 hours each time, every secondary 1 hour, collecting decoction filters, and filtrate and above-mentioned aqueous solution merge, adjust pure content to 85%, precipitate with ethanol left standstill 48 hours, behind the recovery ethanol, with its be concentrated into temperature 60 ℃ the time, relative density is the clear paste of 1.30-1.32, drying under reduced pressure;
(4), with the Bulbus Fritillariae Cirrhosae powder mixing in cream powder in the step (3) and the step (2);
(5), adding volatile oil, salad oil are mixed into the suspension of 50-55% again, make 1000 of soft capsules.
Claims (8)
1, a kind of Chinese medicine for the treatment of infantile asthma is characterized in that: the Chinese medicine of described treatment infantile asthma is the medicament of being made by following materials of weight proportions:
Herba Ephedrae 20-40 part Bulbus Fritillariae Cirrhosae 20-40 part Semen Armeniacae Amarum 40-60 part
Radix Scutellariae 40-60 part Concretio Silicea Bambusae 40-60 part Fructus Perillae 50-70 part
Bombyx Batryticatus 50-70 part Fructus Crataegi 50-70 part Semen Raphani 50-70 part
Gypsum Fibrosum 90-110 part Herba Houttuyniae 110-130 part Herba Asari 3-6 part
Folium Camelliae sinensis 4-6 part Radix Glycyrrhizae 2 0-40 part Radix Platycodonis 40-60 parts
2, a kind of Chinese medicine for the treatment of infantile asthma according to claim 1, it is characterized in that: the Chinese medicine of described treatment infantile asthma is the medicament of being made by following materials of weight proportions:
50 parts of 30 portions of Semen Armeniacae Amarums of 30 parts of Bulbus Fritillariae Cirrhosaes of Herba Ephedrae
60 parts of 50 parts of Fructus Perillaes of 50 parts of Concretio Silicea Bambusaes of Radix Scutellariae
60 parts of 60 parts of Semen Raphanis of 60 portions of Fructus Crataegis of Bombyx Batryticatus
5 parts of 120 parts of Herba Asaris of 100 parts of Herba Houttuyniae of Gypsum Fibrosum
50 parts of 30 parts of Radix Platycodoniss of 5 portions of Radix Glycyrrhizaes of Folium Camelliae sinensis
3, a kind of Chinese medicine for the treatment of infantile asthma according to claim 1 and 2 is characterized in that: described medicament is the above a dosage form of any pharmaceutics.
4, a kind of Chinese medicine for the treatment of infantile asthma according to claim 3, it is characterized in that: described dosage form is granule, tablet, capsule.
5, a kind of Chinese medicine for the treatment of infantile asthma according to claim 4 is characterized in that:
Its preparation process of described granule is as follows:
(1), with Semen Armeniacae Amarum, Fructus Perillae, Bombyx Batryticatus, Fructus Crataegi, Semen Raphani 5 flavor Chinese medicines, fry with slow fire respectively, after concocting, standby;
(2), get Bulbus Fritillariae Cirrhosae powder and be broken into 80-120 purpose fine powder, standby;
(3), with Herba Asari, Herba Houttuyniae extracts volatile oil, aqueous solution after distillation device is in addition preserved, 12 flavors such as medicinal residues and all the other Herba Ephedraes decoct with water secondary, each 1.5 hours, collecting decoction filtered, filtrate and above-mentioned aqueous solution merge, be concentrated into temperature in the time of 85-90 ℃, relative density is the clear paste of 1.38-1.40;
(4), 1 part of qinghuo reagent, with 2.2 parts of sucrose, 0.5 part in dextrin adds the Bulbus Fritillariae Cirrhosae fine powder, mixing is made granule, drying, spray adds Herba Asari, Herba Houttuyniae volatile oil, mixing promptly gets granular preparation.
6, a kind of Chinese medicine for the treatment of infantile asthma according to claim 4 is characterized in that:
Its preparation process of described tablet is as follows:
(1), with Semen Armeniacae Amarum, Fructus Perillae, Bombyx Batryticatus, Fructus Crataegi, Semen Raphani 5 flavor Chinese medicines, fry with slow fire respectively, after concocting, standby;
(2), get Bulbus Fritillariae Cirrhosae powder and be broken into 80-120 purpose fine powder, standby;
(3), with Herba Asari, Herba Houttuyniae extracts volatile oil, the aqueous solution after distillation device is in addition preserved, 12 flavors such as medicinal residues and all the other Herba Ephedraes decoct with water secondary, and each 1.5 hours, collecting decoction, filter, filtrate and above-mentioned aqueous solution merge, and adjust pure content to 65%, precipitate with ethanol, left standstill 48 hours, after reclaiming ethanol, with its be concentrated into temperature 85-90 ℃ the time, relative density is the clear paste of 1.08-1.10, spray drying;
(4), with the Bulbus Fritillariae Cirrhosae powder mixing in cream powder in the step (3) and the step (2), add adjuvant, spray granulation, compacting in flakes, the bag film-coat, promptly.
7, a kind of Chinese medicine for the treatment of infantile asthma according to claim 4 is characterized in that:
Its preparation process of described capsule is as follows:
(1), with Semen Armeniacae Amarum, Fructus Perillae, Bombyx Batryticatus, Fructus Crataegi, Semen Raphani 5 flavor Chinese medicines, fry with slow fire respectively, after concocting, standby;
(2), get Bulbus Fritillariae Cirrhosae powder and be broken into 80-120 purpose fine powder, standby;
(3), with Herba Asari, Herba Houttuyniae extracts volatile oil, the aqueous solution after distillation device is in addition preserved, 12 flavors such as medicinal residues and all the other Herba Ephedraes decoct with water secondary, and each 1.5 hours, collecting decoction, filter, filtrate and above-mentioned aqueous solution merge, and adjust pure content to 65%, precipitate with ethanol, left standstill 48 hours, after reclaiming ethanol, with its be concentrated into temperature 85-90 ℃ the time, relative density is the clear paste of 1.08-1.10, spray drying;
(4), with the Bulbus Fritillariae Cirrhosae powder mixing in cream powder in the step (3) and the step (2), add adjuvant, spray granulation incapsulates, promptly.
8, a kind of Chinese medicine for the treatment of infantile asthma according to claim 3 is characterized in that:
Its preparation process of described soft capsule is as follows:
(1), with Semen Armeniacae Amarum, Fructus Perillae, Bombyx Batryticatus, Fructus Crataegi, Semen Raphani 5 flavor Chinese medicines, fry with slow fire respectively, after concocting, standby;
(2), get Bulbus Fritillariae Cirrhosae powder and be broken into 80-120 purpose fine powder, standby;
(3), with Herba Asari, Herba Houttuyniae extracts volatile oil, the aqueous solution after distillation device is in addition preserved, 12 flavors such as medicinal residues and all the other Herba Ephedraes decoct with water secondary, and 2 hours each time, every secondary 1 hour, collecting decoction filters, and filtrate and above-mentioned aqueous solution merge, adjust pure content to 85%, precipitate with ethanol left standstill 48 hours, behind the recovery ethanol, with its be concentrated into temperature 60 ℃ the time, relative density is the clear paste of 1.30-1.32, drying under reduced pressure;
(4), with the Bulbus Fritillariae Cirrhosae powder mixing in cream powder in the step (3) and the step (2);
(5), adding volatile oil, salad oil are mixed into the suspension of 50-55% again, make soft capsule.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100382479A CN1314387C (en) | 2003-05-21 | 2004-05-18 | Children cough and asthma treating Chinese traditional medicine and its preparation |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 03108056 CN1453018A (en) | 2003-05-21 | 2003-05-21 | Chinese medicine for treating children's dyspneic cough and its prepn |
| CN2003108056.1 | 2003-05-21 | ||
| CN03108056.1 | 2003-05-21 | ||
| CNB2004100382479A CN1314387C (en) | 2003-05-21 | 2004-05-18 | Children cough and asthma treating Chinese traditional medicine and its preparation |
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| Publication Number | Publication Date |
|---|---|
| CN1544071A true CN1544071A (en) | 2004-11-10 |
| CN1314387C CN1314387C (en) | 2007-05-09 |
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| CN101979045A (en) * | 2010-10-28 | 2011-02-23 | 李桂宾 | Medicament for treating cough and asthma diseases |
| CN102512579A (en) * | 2011-12-27 | 2012-06-27 | 彭建 | Chinese medicine for adjuvant therapy of infant bronchitis or pneumonia |
| CN102988652A (en) * | 2012-12-17 | 2013-03-27 | 青岛中科润美润滑材料技术有限公司 | Traditional Chinese medicine composition used for treating exogenous cough of children |
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| CN104127740A (en) * | 2014-08-14 | 2014-11-05 | 孙美玲 | Traditional Chinese medicine preparation used for treating cough and asthma |
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| CN105381351A (en) * | 2015-11-23 | 2016-03-09 | 刘建伟 | Traditional Chinese medicine for treating infantile asthma caused by lung qi obstruction |
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| CN101979045A (en) * | 2010-10-28 | 2011-02-23 | 李桂宾 | Medicament for treating cough and asthma diseases |
| CN101979045B (en) * | 2010-10-28 | 2011-10-05 | 李桂宾 | Medicament for treating cough and asthma diseases |
| CN102512579A (en) * | 2011-12-27 | 2012-06-27 | 彭建 | Chinese medicine for adjuvant therapy of infant bronchitis or pneumonia |
| CN102512579B (en) * | 2011-12-27 | 2013-06-12 | 彭建 | Chinese medicine for adjuvant therapy of infant bronchitis or pneumonia |
| CN102988652A (en) * | 2012-12-17 | 2013-03-27 | 青岛中科润美润滑材料技术有限公司 | Traditional Chinese medicine composition used for treating exogenous cough of children |
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| CN103638283A (en) * | 2013-11-29 | 2014-03-19 | 大连创达技术交易市场有限公司 | Traditional Chinese medicine formula for treating bronchitis |
| CN104027642A (en) * | 2014-06-06 | 2014-09-10 | 黄艳梅 | Traditional Chinese medicine composition for protecting lung and relieving cough for infants |
| CN104127740A (en) * | 2014-08-14 | 2014-11-05 | 孙美玲 | Traditional Chinese medicine preparation used for treating cough and asthma |
| CN106421543A (en) * | 2015-08-12 | 2017-02-22 | 胡东辉 | Traditional Chinese medicine composition for treating cough and preparation method thereof |
| CN106421543B (en) * | 2015-08-12 | 2019-05-21 | 胡东辉 | A kind of Chinese medicine composition and preparation method thereof for treating cough |
| CN105214050A (en) * | 2015-10-29 | 2016-01-06 | 陆康 | A kind of Chinese medicine composition and preparation method thereof for the treatment of cold, fever, dry cough |
| CN106728986A (en) * | 2015-11-19 | 2017-05-31 | 哈尔滨圣吉药业股份有限公司 | A kind of Tabasheer heat phlegm electuary and preparation method thereof |
| CN105381351A (en) * | 2015-11-23 | 2016-03-09 | 刘建伟 | Traditional Chinese medicine for treating infantile asthma caused by lung qi obstruction |
| CN107412462A (en) * | 2017-03-09 | 2017-12-01 | 陕西东科制药有限责任公司 | A kind of preparation method of Huanglong's cough and asthma capsule |
| CN107412462B (en) * | 2017-03-09 | 2020-09-04 | 陕西东科制药有限责任公司 | Preparation method of Huanglong cough and asthma capsule |
| CN116407588A (en) * | 2021-12-29 | 2023-07-11 | 西安碑林药业股份有限公司 | Application of composition in preparation of medicine for preventing/treating hand-foot-mouth disease |
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