CN106421543A - Traditional Chinese medicine composition for treating cough and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating cough and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition for treating cough and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials: radix scutellariae, apricot kernel, platycodon root, Chinese yam, fructus perillae, medicine terminalia fruit, semen raphani, herba violae, scorched hawthorn fruit, malt, rice sprouts, and medicated leaven. The traditional Chinese medicine composition has the functions of clearing away heat and toxic materials, relieving cough and reducing phlegm, and is mainly used for treating cough due to phlegm-heat and reduced appetite.
Description
Technical field
The present invention relates to the field of Chinese medicines is and in particular to a kind of treat Chinese medicine composition of cough and preparation method thereof.
Background technology
Cough refers to the factors such as diseases caused by exogenous pathogenic factor or internal injury, leads to impaired depurative descending of lung QI, abnormal rising of lung-QI, impacts air flue, sends and coughs sound or with a kind of disease coughed up phlegm as Clinical symptoms.Sound no expectorant is referred to as coughed by the successive dynasties, has that expectorant is noiseless referred to as to cough, and has the cough of the sound meaning of expectorant.Clinically it mostly is expectorant sound and sees, be difficult to well-separated, therefore to cough and to claim.Cough is the disease of independence, is a symptom of the multiple disease of lung system again.
Cough is one of most commonly seen disease in internal medicine, and sickness rate is very high, and the sickness rate of chronic cough is 3%-5% according to statistics, and the sickness rate in old people is up to 10% 15%, especially higher with cold district sickness rate.Traditional Chinese medical herbal treatment cough has greater advantage, have accumulated abundant Couple herbs.
《Interior warp》Discussion compared with system being made the problems such as lapsing to and treat to the origin cause of formation of cough, symptom and syndrome-classification, syndrome, having elaborated that climate change, six gas impacts and lung can be so that cough, such as《Plain Questions declares five gas》Say：" five kinds of diseases caused by disorders of ZANG-QI ... disorder of the lung giving rise to cough.”《Plain Questions coughs opinion》It is even more one and discuss a special piece for cough it is indicated that " vital organs of the human body all make us coughing, non-only lung." highlight lungs and cough all can be led to be occurred by evil and visceral dysfunction.The symptom of cough is classified by internal organs, is divided into pulmonary cough, cough referring to the heart, cough involving the stomach, cough involving the urinary bladder etc., and indicates that syndrome lapses to and Therapeutic Principle.The Chinese, written by Zhang Zhongjing《Treatise on Febrile Diseases》《Medical Treasures of the Golden Chamber》Not only draw up many treatment effective prescriptions of cough, cough is carried out with determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs thought has been also presented.
Cough point exogenous cough and endogenous cough, exogenous cough's cause of disease is the heresy of diseases caused by exogenous pathogenic factor six climate exopathogens；Endogenous cough's cause of disease is that the internal injury factor such as diet, feelings will causes visceral dysfunction, interior sick heresy.Exogenous cough and endogenous cough, be all pathogenic factor cause lung qi unclear lose in declare respectful, urgent gas superinverse and cough.The sick position of cough, master dirty in lung, the pathogenic factor no matter diseases caused by exogenous pathogenic factor six climate exopathogens or internal injury are given birth to, all invade and cause cough in lung.
The treatment of cough should distinguish evil positive deficiency and excess.Exogenous cough, be pathogen stop up lung, mostly excess syndrome, thus with eliminating evil profit lung as Therapeutic Principle, according to pathogen wind and cold, wind heat, wind-dryness difference, dispelling wind, cold expelling, heat clearing away, dryness-moistruizing and treating should be respectively adopted.Endogenous cough, to belong to the domination of pathogen weakened body resistance more, therefore with eliminating pathogenic factor for supporting vital QI, giving consideration to both the incidental and fundamental is Therapeutic Principle, is " expectorant " and " fiery " according to pathogenic factor, eliminating evil is respectively adopted weight expectorant, relieves inflammation or internal heat as controlling, weakened body resistance, and yin nourishing or QI invigorating are advisable, and should distinguish the process of deficiency and excess primary and secondary again.
The treatment of cough, in addition to directly controlling lung, also should control spleen, treating the liver, control kidney etc. from entirety attention.Exogenous cough generally individually avoid hold back puckery stay heresy, work as giving treatment in accordance with the tendency of pathological change, the smooth then cough of lung qi of waiting a surname is from only；Endogenous cough should anti-surname dissipate just hinder, and notes conditioning viscera, turns round and look at shield healthy energy.
Content of the invention
It is an object of the invention to provide a kind of Chinese medicine composition treating cough；
It is a further object of the present invention to provide a kind of Chinese medicine composition preparation method treating cough.
The purpose of the present invention is to be realized by following technical scheme：
The Chinese medicine composition for the treatment of cough of the present invention, it is to be prepared from by the raw material including following weight portion：
Radix Scutellariae 2-30 part, Semen Armeniacae Amarum 2-30 part, Radix Platycodoniss 2-30 part, Rhizoma Dioscoreae 2-30 part, Fructus Perillae 2-30 part, terminalia flesh 2-30 part, Semen Raphani 2-30 part, Herba Violae 10-50 part, Fructus Crataegi (parched to brown) 1-15 part, Fructus Hordei Germinatus 1-15 part, Fructus Setariae Germinatuss 1-15 part, Massa Medicata Fermentata 1-15 part.
Preferably, it is to be prepared from by the raw material including following weight portion：
Radix Scutellariae 4-20 part, Semen Armeniacae Amarum 4-20 part, Radix Platycodoniss 4-20 part, Rhizoma Dioscoreae 4-20 part, Fructus Perillae 4-20 part, terminalia flesh 4-20 part, Semen Raphani 4-20 part, Herba Violae 15-40 part；Fructus Crataegi (parched to brown) 1-10 part, Fructus Hordei Germinatus 1-10 part, Fructus Setariae Germinatuss 1-10 part, Massa Medicata Fermentata 1-10 part.
The following is the crude drug source of Chinese medicine composition of the present invention：
Radix Scutellariae, is labiate Radix Scutellariae Scutellaria baicalensis
The dry root of Georgi.【Nature and flavor】Hardship, trembles with fear.【Return through】Return lung, gallbladder, spleen, large intestine, small intestine meridian.【Indication】Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, hyperpyrexia excessive thirst, blood-head tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.
Semen Armeniacae Amarum, is the dry seed of the bitter in the mouth such as rosaceous plant Fructus Pruni or Prunus armeniaca L.var.ansu Maxim..【Nature and flavor】Hardship, temperature, poisonous.【Return through】Enter lung, large intestine channel.【Indication】Expelling phlegm for arresting cough, relievings asthma, intestine moistening.Control exogenous cough, dyspnea with fullness of the chest, sore throat, dry constipation of intestines.
Radix Platycodoniss, are Campanulaceae Radix Platycodoniss Platycodon grandiflorum（Jacq.）A.DC. dry root.【Nature and flavor】Bitter, pungent, put down.【Return through】Return lung warp.【Indication】Lung qi dispersing, sore-throat relieving, eliminating the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung carbuncle pyemesis, skin infection difficulty in discharging of pus.
Rhizoma Dioscoreae, is the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae Dioscorea opposita Thunb..【Nature and flavor】Sweet, put down.【Return through】Returns spleen, lung, kidney channel.【Indication】Spleen reinforcing nourishing the stomach, engender liquid and benefic lung, the kidney invigorating arresting seminal emission.For spleen eating less, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Rhizoma Dioscoreae (parched with bran) good efficacy to suffering from a deficiency of the kidney.For spleen eating less, loose stool of having loose bowels, leukorrhagia.
Fructus Perillae, is labiate Folium Perillae Perilla frutescens（L.）Britt. dry mature fruit.【Nature and flavor】Pungent, temperature.【Return through】Return lung warp.【Indication】Sending down the abnormal ascending QI expectorant, relievings asthma, intestine moistening.For phlegm stops up the circulation of vital energy in the wrong direction, cough and asthma, dry constipation of intestines.
Terminalia flesh, Combretum Racemosum plant Fructus Chebulae Terminalia chebula Retz. or Terminalia chebula Retz. var. tomentella Kurt. Terminalia chebula Retz. var.
The dry mature fruit of tomentella Kurt., cleans, slightly soaks, moistening, enucleation, is dried and is obtained.【Nature and flavor】Bitter, sour, puckery, put down.【Return through】Return lung, large intestine channel.【Indication】Astringing intestine to stop diarrhea is astringed the lung, pathogenic fire reducing sore-throat relieving.For protracted dysentery and diarrhea, proctoptosis of having blood in stool, the deficiency of the lung is breathed with cough, and chronic cough is more than, pharyngalgia hoarseness.
Semen Raphani, is the dry mature seed of crucifer Radix Raphani Raphanus sativus L..【Nature and flavor】Pungent, sweet, put down.【Return through】Return lung, spleen, stomach.【Indication】Help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.For retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough.
Herba Violae, be Violaceae Chinese violet Viola yedoensis Makino herb is dried.【Nature and flavor】Bitter, acrid, cold.【Return through】GUIXIN, Liver Channel.【Indication】Heat-clearing and toxic substances removing, cool blood detumescence.For furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom.
Fructus Crataegi (parched to brown), is the dry mature fruit of rosaceous plant Fructus Pyri Pashiae Crataegus pinnatifida Bge.var.major N.E.Br. or Fructus Crataegi Crataegus pinnatifida Bge., cleans section, puts in pot, fry to surface coke brown, internal yellowish-brown.【Nature and flavor】Sour, sweet, tepor.【Return through】Returns spleen, stomach, Liver Channel.【Indication】Dyspepsia and intestinal stasis relieving effect strengthens.For meat stagnation, dysentery is not well.
Fructus Hordei Germinatus, are that the mature fruit of grass Fructus Hordei Vulgaris Hordeum vulgare L. obtains through drying of germinateing.【Nature and flavor】Sweet, put down.【Return through】Returns spleen, stomach.【Indication】Promoting the circulation of qi helps digestion, spleen benefiting and stimulating the appetite, moves back newborn dissipate-swelling.For dyspepsia, abdominal distention, spleen eating less, milk smoulders, distending pain of the breast, women weans.
Fructus Setariae Germinatuss, are grass foxtail millet Setaria italica（L.）Beauv. mature fruit is dried through germinateing and obtains.【Nature and flavor】Sweet, temperature.【Return through】Returns spleen, stomach.【Indication】Help digestion and in, spleen benefiting and stimulating the appetite.For dyspepsia, abdominal distention halitosis, weakness of the spleen and stomach, not hungry lack of appetite.
Massa Medicata Fermentata, is fermented herbal leaven after the medicines such as Herba polygoni hydropiperis, Herba Artemisiae Annuae, Semen Armeniacae Amarum add flour or wheat bran mixing.【Nature and flavor】Sweet, acrid, warm.【Return through】Enter spleen, stomach.【Indication】Invigorating the spleen and regulating the stomach, helps digestion in tune.Control retention of food and drink, feeling of stuffiness in chest abdominal distention, vomiting dysentery, postnatal blood stasis are suffered from abdominal pain, children's enlarged abdomen is hard long-pending.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and the method is to be prepared from using using the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume.Concrete preparation method is as follows：
Scheme one：Take 12 taste medical materials, extracting in water 2-3 time after mixing, each amount of water is equivalent to 6-12 times of medical material gross weight, extraction time is 1-3 hour every time, united extraction liquid, filtration, it is the clear paste of 1.15-1.20 that filtrate is concentrated into relative density when 70-80 DEG C, obtains final product active component.
Scheme two：Take 12 taste medical materials, after mixing, use 40-80% alcohol reflux 2-3 time, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-4 hour, and united extraction liquid filters, it is the clear paste of 1.15-1.20 that filtrate is concentrated into relative density when 70-80 DEG C, obtains final product active component.
Scheme three：Take 12 taste medical materials, extracting in water 2-3 time after mixing, each amount of water is equivalent to 6-12 times of medical material gross weight, extraction time is 1-3 hour every time, united extraction liquid, filtration, it is the clear paste of 1.15-1.20 that filtrate is concentrated into relative density when 70-80 DEG C, add ethanol, make alcohol content be 40-70%, stand 12-24 hour, filtration, it is the extractum of 1.10-1.25 that filtrate is concentrated into relative density when 70-80 DEG C, obtains final product active component.
The Chinese medicine composition for the treatment of cough of the present invention, can also make various oral formulations with pharmaceutically acceptable carrier combination, such as tablet, capsule, oral liquid, syrup, mixture etc..
The pharmaceutically acceptable carrier of the present invention is including but not limited to following：
Oral formulations：
Diluent：Starch, Icing Sugar, Lactose, dextrin, Microcrystalline Cellulose, inorganic salt, sugar alcohols etc..
Wetting agent and binding agent：Purified water, ethanol, gelatin, Polyethylene Glycol, cellulose derivative etc..
Disintegrating agent：Starch, carboxymethyl starch sodium, cellulose derivative, Crospovidone etc..
Lubricant：Magnesium stearate, micropowder silica gel, Pulvis Talci, Polyethylene Glycol etc..
Cosolvent：Water, ethanol, glycerol, propylene glycol, liquid Paraffin, vegetable oil etc..
Correctivess：Sucrose, monosaccharide, aromatic etc..
Preservative：Benzoic acid, sorbic acid, methyl ester, ethyl ester, propyl ester etc..
Method 1：Tablet
Take scheme one one of to scheme three gained active component, add tablet to commonly use adjuvant, routinely production method is prepared into Tablets.
Above-mentioned tablet is commonly used adjuvant and is included one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 1：Capsule
Take scheme one one of to scheme three gained active component, add capsule to commonly use adjuvant, routinely production method is prepared into capsule of the present invention.
Above-mentioned capsule is commonly used adjuvant and is included one of diluent, wetting agent, binding agent, disintegrating agent, lubricant or whole.
Method 3：Syrup
Take scheme one one of to scheme three gained active component, add syrup to commonly use adjuvant, routinely production method is prepared into syrup of the present invention.
Above-mentioned syrup is commonly used adjuvant and is included one of correctivess, preservative, cosolvent or whole.
Method 4：Mixture
Take scheme one one of to scheme three gained active component, add mixture to commonly use adjuvant, routinely production method is prepared into mixture of the present invention.
Above-mentioned mixture is commonly used adjuvant and is included one of correctivess, preservative or whole.
Method 5：Oral liquid
Take scheme one one of to scheme three gained active component, dissolving after-purification, concentration, add oral liquid to commonly use adjuvant, routinely production method is prepared into oral liquid of the present invention.
Above-mentioned oral liquid is commonly used adjuvant and is included one of correctivess, preservative, cosolvent or whole.
The applicant with reference to modern pharmacological research achievement, through test for many years, multiple formulations is screened on the basis of research Traditional Chinese Medicine Coryza Treated by Syndrome Differentiation, have found the Chinese medicine formula of energy effectively treatment cough, Radix Scutellariae clearing away heat-fire in side, controls cough due to lung-heat；Semen Armeniacae Amarum expelling phlegm for arresting cough, controls exogenous cough；Radix Platycodoniss lung qi dispersing sore-throat relieving eliminating the phlegm, for cough with copious phlegm；Rhizoma Dioscoreae lung benefiting promotes the production of body fluid, for cough and asthma due to lung deficiency；Fructus Perillae sending down the abnormal ascending QI eliminating phlegm to relieve asthma, for phlegm stops up the circulation of vital energy in the wrong direction, cough and asthma；Terminalia flesh is astringed the lung pathogenic fire reducing, breathes with cough for the deficiency of the lung, chronic cough is more than；Semen Raphani lowering the adverse-rising QI to resolve phlegm, stops up for expectorant and breathes with cough；It is aided with Herba Violae heat-clearing and toxic substances removing, Fructus Crataegi (parched to brown), Fructus Hordei Germinatus, Fructus Setariae Germinatuss, Massa Medicata Fermentata invigorating the spleen and regulating the stomach, for stomach-QI being unable to descend normally, transmitting and distributing the fluids function reduction, lead to the cough with copious phlegm that disturbance of lung-QI causes.Side is mutually collaborative entirely, has functions that heat-clearing and toxic substances removing, relieving cough and resolving phlegm, cures mainly phlegm-heat cough, lack of appetite.
A kind of Chinese medicine composition treating cough that the present invention provides has advantages below：
1st, the composite preparation that the present invention provides safely and effectively, has functions that heat-clearing and toxic substances removing, relieving cough and resolving phlegm, cures mainly phlegm-heat cough, lack of appetite.
2nd, clinical tests prove that, after traditional Chinese medicine composition for treating of the present invention, the cure rate to a phlegm-heat cough is 48.8% to patient, and total effective rate is 90.7%.
3rd, the Chinese medicinal composition preparation that the present invention provides, scientific formulation is reasonable, process is simple, in good taste, low cost.
Specific embodiment
Further illustrate the present invention below by embodiment.It should be understood that embodiments of the invention are for illustrating rather than limitation of the present invention.Broadly fall into the scope of protection of present invention according to the simple modifications that the essence of the present invention is carried out to the present invention.Unless otherwise stated, the percent of the amount of alcohol in the present invention is percentage by volume, and v/v represents the volume ratio of solution.
Embodiment 1 tablet
Weigh Radix Scutellariae 0.2kg, Semen Armeniacae Amarum 0.2kg, Radix Platycodoniss 0.2kg, Rhizoma Dioscoreae 0.2kg, Fructus Perillae 0.2kg, terminalia flesh 0.2kg, Semen Raphani 0.2kg, Herba Violae 1kg, Fructus Crataegi (parched to brown) 0.1kg, Fructus Hordei Germinatus 0.1kg, Fructus Setariae Germinatuss 0.1kg, Massa Medicata Fermentata 0.1kg.Extracting in water 3 times, three amount of water are respectively 12 times, 8 times, 6 times of medical material gross weight, three extraction times are respectively 3 hours, 2 hours, 1 hour, united extraction liquid, filtration, when filtrate is concentrated into 70 DEG C, relative density is 1.25 clear paste, adds supplementary product starch, ethanol, Pulvis Talci, prepared tablet.
Embodiment 2 tablet
Weigh Radix Scutellariae 3kg, Semen Armeniacae Amarum 3kg, Radix Platycodoniss 3kg, Rhizoma Dioscoreae 3kg, Fructus Perillae 3kg, terminalia flesh 3kg, Semen Raphani 3kg, Herba Violae 5kg, Fructus Crataegi (parched to brown) 1.5kg, Fructus Hordei Germinatus 1.5kg, Fructus Setariae Germinatuss 1.5kg, Massa Medicata Fermentata 1.5kg.With 40% alcohol reflux 3 times, ethanol consumption is respectively 10 times, 8 times, 4 times of medical material total amount every time, 3 hours, 2 hours, 1 hour respectively extraction time, united extraction liquid, filter, when filtrate concentrates 60 DEG C, relative density is 1.25 extractum, adds supplementary product starch, ethanol, Pulvis Talci, prepared tablet.
Embodiment 3 granule
Weigh Radix Scutellariae 1kg, Semen Armeniacae Amarum 1.2kg, Radix Platycodoniss 0.8kg, Rhizoma Dioscoreae 0.5kg, Fructus Perillae 2kg, terminalia flesh 1.5kg, Semen Raphani 0.8kg, Herba Violae 1.2kg, Fructus Crataegi (parched to brown) 0.5kg, Fructus Hordei Germinatus 0.5kg, Fructus Setariae Germinatuss 0.5kg, Massa Medicata Fermentata 0.5kg.Extracting in water 3 times, three times amount of water is respectively equivalent to 12 times of medical material gross weight, 8 times, 6 times, 3 hours, 2 hours, 1 hour respectively each extraction time, united extraction liquid, filtration, when filtrate is concentrated into 70 DEG C, relative density is 1.20 clear paste, adds ethanol, alcohol content is made to be 40%, standing 24 hours, filtration, filtrate is concentrated into the extractum that relative density when filtrate is concentrated into 70 DEG C is 1.10, add starch, dextrin, pelletize, be dried, granulate obtains final product.
Embodiment 4 capsule
Weigh Radix Scutellariae 2kg, Semen Armeniacae Amarum 2kg, Radix Platycodoniss 2kg, Rhizoma Dioscoreae 2kg, Fructus Perillae 2kg, terminalia flesh 2kg, Semen Raphani 2kg, Herba Violae 4kg, Fructus Crataegi (parched to brown) 1kg, Fructus Hordei Germinatus 1kg, Fructus Setariae Germinatuss 1kg, Massa Medicata Fermentata 1kg.With alcohol reflux 2 times, concentration of alcohol is respectively 80%, 60% every time, ethanol consumption is respectively 10 times, 8 times of medical material total amount every time, extraction time is respectively 4 hours, 3 hours, united extraction liquid, filters, when filtrate is concentrated into 80 DEG C, relative density is 1.10 extractum, add supplementary product starch, ethanol, dextrin, magnesium stearate in extractum, make capsule according to a conventional method.
Embodiment 5 oral liquid
Weigh Radix Scutellariae 0.4kg, Semen Armeniacae Amarum 0.4kg, Radix Platycodoniss 0.4kg, Rhizoma Dioscoreae 0.4kg, Fructus Perillae 0.4kg, terminalia flesh 0.4kg, Semen Raphani 0.4kg, Herba Violae 1.5kg, Fructus Crataegi (parched to brown) 0.1kg, Fructus Hordei Germinatus 0.1kg, Fructus Setariae Germinatuss 0.1kg, Massa Medicata Fermentata 0.1kg.Extracting in water 2 times, amount of water is respectively 10 times, 8 times of medical material gross weight twice, extraction time is respectively 2 hours, 1 hour twice, united extraction liquid, filtration, when filtrate is concentrated into 80 DEG C, relative density is 1.10 extractum, adds adjuvant Mannitol, sorbic acid, water to stir in extractum, subpackage, prepared oral liquid.
Embodiment 6 granule
Weigh Radix Scutellariae 2.5kg, Semen Armeniacae Amarum 1.5kg, Radix Platycodoniss 2kg, Rhizoma Dioscoreae 1.8kg, Fructus Perillae 2.5kg, terminalia flesh 0.8kg, Semen Raphani 0.5kg, Herba Violae 3kg, Fructus Crataegi (parched to brown) 1.2kg, Fructus Hordei Germinatus 0.5kg, Fructus Setariae Germinatuss 1kg, Massa Medicata Fermentata 0.8kg.Extracting in water 2 times, each amount of water is respectively equivalent to 12 times of medical material gross weight, 10 times, and each extraction time is respectively 3 hours, 2 hours, united extraction liquid, filtration, filtrate is concentrated into the clear paste that relative density at 80 DEG C is 1.05, adds ethanol, alcohol content is made to be 70%, standing 12 hours, filtration, when filtrate is concentrated into 70 DEG C, relative density is 1.25 extractum, add starch, dextrin, pelletize, be dried, granulate obtains final product.
Embodiment 7 syrup
Weigh Radix Scutellariae 1.5kg, Semen Armeniacae Amarum 1.2kg, Radix Platycodoniss 2.8kg, Rhizoma Dioscoreae 0.5kg, Fructus Perillae 1.2kg, terminalia flesh 1.5kg, Semen Raphani 2kg, Herba Violae 2.5kg, Fructus Crataegi (parched to brown) 0.3kg, Fructus Hordei Germinatus 0.5kg, Fructus Setariae Germinatuss 0.5kg, Massa Medicata Fermentata 0.3kg.Extracting in water 2 times, 10 times, 8 times of amount of water respectively medical material gross weight, extraction time respectively 2 hours, 1 hour twice, united extraction liquid, filtration twice, when filtrate is concentrated into 80 DEG C, relative density is 1.10 extractum.Syrup adjuvant sucrose, sorbic acid, water is added to stir in extractum, prepared syrup.
Embodiment 8 mixture
Weigh Radix Scutellariae 2kg, Semen Armeniacae Amarum 2kg, Radix Platycodoniss 2kg, Rhizoma Dioscoreae 2kg, Fructus Perillae 2kg, terminalia flesh 2kg, Semen Raphani 2kg, Herba Violae 3.5kg, Fructus Crataegi (parched to brown) 0.5kg, Fructus Hordei Germinatus 0.5kg, Fructus Setariae Germinatuss 0.5kg, Massa Medicata Fermentata 0.5kg.Extracting in water 3 times, three times amount of water is respectively equivalent to 12 times of medical material gross weight, 8 times, 6 times, extraction time 3 hours, 2 hours, 1 hour respectively every time, united extraction liquid, filtration, filtrate concentrates 3 times that ad pond om is medical material gross weight, fill, mixture adjuvant sucrose, ethyl ester, water, sorbic acid is added to stir, prepared mixture.
Embodiment 9 powder
Weigh Radix Scutellariae 2.5kg, Semen Armeniacae Amarum 2kg, Radix Platycodoniss 2kg, Rhizoma Dioscoreae 1.8kg, Fructus Perillae 1.2kg, terminalia flesh 1.5kg, Semen Raphani 2kg, Herba Violae 3kg, Fructus Crataegi (parched to brown) 1kg, Fructus Hordei Germinatus 1kg, Fructus Setariae Germinatuss 1kg, Massa Medicata Fermentata 1kg.Pulverize, sieve, obtain final product.
Clinical trial
First, the clinical observation to phlegm-heat cough patient
1 physical data
Observe 86 cough patients.Women 38 in 86 patients, male 48, the range of age：18～55 years old.
2 diagnostic criterias
Primary symptom:1st, cough is not well；2nd, expectorant is turbid sticky or yellow；3rd, red tongue, yellow fur or yellow greasy；4th, wiry and frequent pulse or sliding number.
Secondary disease:Heating, pharyngalgia, thirsty, uncomfortable in chest, general fatigue, it is hard and dry or half congealed and not well, oliguria with reddish urine.
Primary symptom 1 is indispensable, and has 2 in 2,3,4 primary symptoms, or primary symptom 1 is indispensable, and to have in primary symptom 2,3,4 wantonly 2 persons in wantonly 1 and secondary disease be diagnosable.
3 inclusive criterias
Cough belongs to the hot patient of expectorant, course of disease person within 1 week, and the age is between 18～55 years old.
4 evaluation criterias
Recovery from illness:Cough, expectoration, heating disappear, and other simultaneous phenomenons are clearly better.
Effective:Cough, expectoration, heating are clearly better, and other simultaneous phenomenons have taken a turn for the better.
Effectively:Cough, expectoration, heating have taken a turn for the better, and other simultaneous phenomenon changes are less.
Invalid:Clinical symptoms are no improved or are increased.
5 Therapeutic Method
Give the embodiment of the present invention 5 oral liquid treatment, 2 every time, every 10ml, 3 times a day.
6 results
Through the treatment of 5-7 days, clinical efficacy was shown in Table 1.
The clinical efficacy of table 1 present invention treatment cough
| n | Recovery from illness | Effective | Effectively | Invalid | Cure rate（%） | Total effective rate（%） | |
| Curative effect | 86 | 42 | 18 | 18 | 8 | 48.8 | 90.7 |
As shown in Table 1, after the treatment of 5-7 days, the present invention is 48.8% to the cure rate of phlegm-heat cough, and total effective rate is 90.7%.Result shows：Chinese medicine composition phlegm-heat cough of the present invention has preferable therapeutical effect.
Model case
Wei, female, see when medical that its expression is wan and sallow, lustreless complexion, the tasteless, yellowish fur on the tongue of food of receiving, wiry and frequent pulse, readme cough two and Ban, thick sputum.X-ray checks increased bronchovascular shadows, and double pulmonary respiration sounds of having a medical check-up are thick.It is diagnosed as phlegm-heat cough.The embodiment of the present invention 4 capsule is given to treat, after 5 days, cough symptom almost disappears, following the service 3 days, and all cards remove to the greatest extent, and follow-up after 1 week is no recurred.
Although, above used general explanation, specific embodiment and test, the present invention is described in detail, on the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, belong to the scope of protection of present invention.
Claims (7)
1. a kind of Chinese medicine composition treating cough is it is characterised in that it is to be made up of the raw material of Chinese medicine including following weight portion：
Radix Scutellariae 2-30 part, Semen Armeniacae Amarum 2-30 part, Radix Platycodoniss 2-30 part, Rhizoma Dioscoreae 2-30 part, Fructus Perillae 2-30 part, terminalia flesh 2-30 part, Semen Raphani 2-30 part, Herba Violae 10-50 part, Fructus Crataegi (parched to brown) 1-15 part, Fructus Hordei Germinatus 1-15 part, Fructus Setariae Germinatuss 1-15 part, Massa Medicata Fermentata 1-15 part.
2. the Chinese medicine composition for the treatment of cough as claimed in claim 1 is it is characterised in that it is to be made up of the raw material of Chinese medicine including following weight portion：
Radix Scutellariae 4-20 part, Semen Armeniacae Amarum 4-20 part, Radix Platycodoniss 4-20 part, Rhizoma Dioscoreae 4-20 part, Fructus Perillae 4-20 part, terminalia flesh 4-20 part, Semen Raphani 4-20 part, Herba Violae 15-40 part；Fructus Crataegi (parched to brown) 1-10 part, Fructus Hordei Germinatus 1-10 part, Fructus Setariae Germinatuss 1-10 part, Massa Medicata Fermentata 1-10 part.
3. the Chinese medicine composition for the treatment of cough as claimed in claim 1 or 2 is it is characterised in that its active component is to be prepared from using the ethanol extraction of water extraction or 40-80% concentration expressed in percentage by volume.
4. the Chinese medicine composition for the treatment of cough as claimed in claim 3 is it is characterised in that its active component is prepared by the following method and forms：Take 12 taste medical materials, extracting in water 2-3 time after mixing, each amount of water is equivalent to 6-12 times of medical material gross weight, extraction time is 1-3 hour every time, united extraction liquid, filtration, it is the clear paste of 1.15-1.20 that filtrate is concentrated into relative density when 70-80 DEG C, obtains final product active component.
5. the Chinese medicine composition for the treatment of cough as claimed in claim 3 is it is characterised in that its active component is prepared by the following method and forms：Take 12 taste medical materials, after mixing, use 40-80% alcohol reflux 2-3 time, each ethanol consumption is 4-10 times of medical material total amount, extraction time is 1-4 hour, and united extraction liquid filters, it is the clear paste of 1.15-1.20 that filtrate is concentrated into relative density when 70-80 DEG C, obtains final product active component.
6. the Chinese medicine composition for the treatment of cough as claimed in claim 3 is it is characterised in that its active component is prepared by the following method and forms：Take 12 taste medical materials, extracting in water 2-3 time after mixing, each amount of water is equivalent to 6-12 times of medical material gross weight, extraction time is 1-3 hour every time, united extraction liquid, filtration, it is the clear paste of 1.15-1.20 that filtrate is concentrated into relative density when 70-80 DEG C, add ethanol, make alcohol content be 40-70%, stand 12-24 hour, filtration, it is the extractum of 1.10-1.25 that filtrate is concentrated into relative density when 70-80 DEG C, obtains final product active component.
7. a kind of Chinese medicine composition treating cough, the Chinese medicine composition of the treatment cough described in claim 1 or 2 is prepared from pharmaceutically acceptable carrier combination.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1544071A (en) * | 2003-05-21 | 2004-11-10 | 西安碑林药业股份有限公司 | Children cough and asthma treating Chinese traditional medicine and its preparation |
| CN102430091A (en) * | 2011-12-13 | 2012-05-02 | 荣成市科学技术情报研究所 | Chinese medicinal composition for treating children cough |
| CN103083584A (en) * | 2011-11-04 | 2013-05-08 | 陈良鉴 | Traditional Chinese medicine for treating influenza |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1544071A (en) * | 2003-05-21 | 2004-11-10 | 西安碑林药业股份有限公司 | Children cough and asthma treating Chinese traditional medicine and its preparation |
| CN103083584A (en) * | 2011-11-04 | 2013-05-08 | 陈良鉴 | Traditional Chinese medicine for treating influenza |
| CN102430091A (en) * | 2011-12-13 | 2012-05-02 | 荣成市科学技术情报研究所 | Chinese medicinal composition for treating children cough |
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