CN104324209B - One kind treats snorting Chinese medicine composition of pig and preparation method thereof - Google Patents
One kind treats snorting Chinese medicine composition of pig and preparation method thereof Download PDFInfo
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- CN104324209B CN104324209B CN201410561505.5A CN201410561505A CN104324209B CN 104324209 B CN104324209 B CN 104324209B CN 201410561505 A CN201410561505 A CN 201410561505A CN 104324209 B CN104324209 B CN 104324209B
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Abstract
Snorting Chinese medicine composition of pig and preparation method thereof is treated the present invention relates to one kind.The Chinese medicine composition is prepared from by following Chinese medicine material：Chinese ephedra, semen armeniacae amarae, radix scutellariae, orange, balloonflower root, fritillary bulb, the wind-weed, the root bark of white mulberry, gypsum, radix glycyrrhizae.Chinese medicine composition of the present invention have the advantages that conveniently, safely, it is economical, and therapeutic effect is preferable.
Description
Technical field
The present invention relates to the field of Chinese medicines, and in particular to treatment snorting Chinese medicine composition of pig and preparation method thereof.
Background technology
Swine enzootic pneumonia or mycoplasma pneumonia of swine, also known as mycoplasma hyopneumoniae, are a kind of chronic respiratory infectious diseases of pig.This disease
Main clinic symptoms be cough and asthma, pathological change position is predominantly located in thoracic cavity.Lungs are the major organs of lesion.It is anxious
Venereal disease example is based on pulmonary edema and pulmonary emphysema；Subacute and chronic cases are shown in lung " shrimp " sample consolidation.The growth speed of morbid pig
Degree is slow, and efficiency of feed utilization is low, the extension of feeding for fattening phase.
This disease is also known as porcine mycoplasmal pneumonia and epidemic swine pneumonia.All pig-raising countries have this disease popular, this
Disease is caused by mycoplasma hyopneumoniae.The infection of sucking pig is mostly caused by contacting the sow with this disease.Infected sucking pig exists
Other pigs are relayed during ablactation again.Dense husbandry can promote it to propagate.This sick incubation period is longer, therefore has more swinerys to exist
It is infected under not being discovered, cause this disease often to be deposited in what swinery.This sick infection rate is high, and the death rate is low, but can cause growth
Obstacle and reduction meat change rate.In other words, the feeding period of pig listing will be extended.
Pig pneumonia gas substance is to cause one of 3 kinds of main pathogens of porcine respiratory disease, suffers from breathing problem in pig
Recall rate is about 19% in case.Mycoplasma hyopneumoniae be primarily present in the respiratory tracts of infected pigs, lung tissue, hilar lymph node and
In vertical phrenic lymph nodes, sick pig and the pig that carries disease germs are its major source of infection.Its route of transmission mainly has：Respiratory infectious, directly contact
Propagate and droplet transmission, pathogeny Jun Zhi infected pigs；Initial infection mycoplasma hyopneumoniae is present in trachea and bronchus surface, and damages
Evil mucous membrane-cilium barrier, making bronchus and blood vessel peripheral lymphoid like cell hyperplasia, (immune response substantially participates in pathological development cause
Lungs are made to occur consolidation)；Infected pigs the immune response of mycoplasma hyopneumoniae is taken place mostly in disease later stage (15 after infection~
20 weeks), it can be seen that this infection has certain immunosuppressive action.
This sick clinical symptoms and dissection lesion, are available for the reference in diagnosis.When large numbers of pigs battle array property dry cough, breathe, grow
Block or delay but very low death rate etc. can suspect it is this disease.It is between the focus of lung and normal lung tissue points to dissect lesion
Boundary understands, both sides are symmetrical and diseased region mostly limits the sharp leaf of what, lobus cardiacus, middle leaf and every leaf front lower portion.There is the solid sensation of pancreas sample.
In the case of natural infection, easy secondary Pasteurella, pneumococcus, Actinobacillus pleuropneumoniae, Salmonella bar
Bacterium and various suppurative bacteriums, mycoplasma hyorhinis and granular Chlamydia etc., so as to cause patient's condition aggravation and death rate rise.
General antiseptic such as sulfanilamide (SN), penicillin, streptomysin and erythromycin etc. are all without therapeutic action.Quinolones of new generation is
The curative optimal to this disease.The weak plain freeze-dried vaccine of mycoplasma pneumonia of swine of domestic production can be used for 20-25 ages in days sodium selenite, immunization rate
Up to more than 80%.Pig farm must voluntarily breed kind of a swinery, strictly prevent this encephalapthy agent to invade.
Because mycoplasma hyopneumoniae can change surface antigen and cause immunologic escape, immunity is caused to weaken, therefore pig
Field need to coordinate medical treatment, and general 3~5 days an of course for the treatment of, particularly farrowing sow spice purification, its pig that farrows individually are raised
Support, use of not reserving seed for planting, segregated early weaning is carried out on the pig farm that condition possesses, and the time of contact of sow and piglet is reduced as far as possible.
The content of the invention
The snorting Chinese medicine composition of pig is treated it is an object of the invention to provide one kind；
It is a further object of the present invention to provide a kind of preparation method for treating the snorting Chinese medicine composition of pig.
The purpose of the present invention is realized by following technical scheme：
The treatment snorting Chinese medicine composition of pig of the present invention, it is prepared from by the raw material of following parts by weight：
40-60 parts of Chinese ephedra, 25-35 parts of semen armeniacae amarae, 20-30 parts of radix scutellariae, 25-35 parts of orange, 25-35 parts of balloonflower root, fritillary bulb
25-35 parts, 25-35 parts of the wind-weed, 25-35 parts of the root bark of white mulberry, 80-120 parts of gypsum, 15-25 parts of radix glycyrrhizae.
Preferably, it is to be prepared from by the raw material of following parts by weight：
50 parts of Chinese ephedra, 30 parts of semen armeniacae amarae, 25 parts of radix scutellariae, 30 parts of orange, 30 parts of balloonflower root, 30 parts of fritillary bulb, 30 parts of the wind-weed, mulberry
White 30 parts of skin, 100 parts of gypsum, 20 parts of radix glycyrrhizae.
Chinese medicine source and primary efficacy the following is the present invention treatment snorting Chinese medicine composition of pig：
Chinese ephedra：For Ephedraceae plant ephedra sinica Ephedra sinica Stapf, epheday intermedia Ephedra intermedia
Schrenk et C.A.Mey. or ephedra equisetina Ephedra equisetina Bge. drying herbaceous stem stem.Autumn end taps green
Herbaceous stem stem, dry.【Nature and flavor and channel tropism】Pungent, slight bitter, temperature.Return lung, bladder warp.【Function is with curing mainly】Sweating cold dispelling, facilitaing lung is put down
Breathe heavily, inducing diuresis for removing edema.It is uncomfortable in chest to breath with cough for anemofrigid cold, geomantic omen edema.Herba ephedrae moistens the lung and relieve the cough.It is used for exterior syndrome to have solved, pants
Cough.
Semen armeniacae amarae：For rosaceous plant ansu apricot Prunus armeniaca L.var.ansu Maxim., Siberia apricot
Prunus sibirica L., prunus mandshuricaKoehne Prunus mandshurica (Maxim.) Koehne or apricot Prunus armeniaca
L. dry mature seed.Summer harvests ripening fruits, removes in fruit and nucleocapsid, takes out seed, dry.【Nature and flavor write channel tropism】
Hardship, tepor；It is slightly poisonous.Return lung, large intestine channel.【Function is with curing mainly】Sending down abnormally ascending is relieving cough and asthma, relaxes bowel.For cough and asthma, chest
Full abundant expectoration, dry constipation of intestines.
Radix scutellariae：For labiate radix scutellariae Scutellaria baicalensis Georgi dry root.Spring, Qiu Erji
Excavation, removes fibrous root and silt, hits tertia after solarization, dry.【Nature and flavor and channel tropism】Hardship, trembles with fear.Return lung, courage, spleen, large intestine, small intestine
Through.【Function is with curing mainly】Heat-clearing and damp-drying drug, purging intense heat and detonicating, hemostasis is antiabortive.For damp-warm syndrome, summer-heat and damp, evil of vomitting uncomfortable in chest, damp and hot feeling of fullness is rushed down
Dysentery, jaundice, cough with lung heat, hyperpyrexia polydipsia blood-head tells nosebleeds, carbuncle sore tumefacting virus, fetal irritability.
Orange：For Rutaceae Rutaceae Citrus Citrus plant orange Citrus reticulata.【Nature and flavor are with returning
Through】It is sweet acid, warm-natured, enter lung, stomach.【Function is with curing mainly】With appetizing qi-regulating, the effect for moistening lung of quenching the thirst, cure mainly septum pectorale knot gas,
Vomit very thirsty, cough with lung heat and insobriety in inverse few food, deficiency of stomach-Yin, mouth.
Balloonflower root：For Campanulaceae balloonflower root Platycodon grandiflorum (Jacq.) A.Dc. dry root.Spring,
Qiu Erji excavate, clean, remove fibrous root, take advantage of it is fresh peel off crust or do not remove crust, dry.【Nature and flavor and channel tropism】It is bitter, pungent, put down.Return
Lung channel.【Function is with curing mainly】Facilitaing lung, relieving sore-throat, eliminating the phlegm, apocenosis.For coughing with a lot of sputum, uncomfortable in chest not smooth, pharyngalgia sound is mute, lung carbuncle pyemesis.
Fritillary bulb：For liliaceous plant fritillary bulb Fritillaria ussuriensis Maxim. dry bulb.Spring
Season excavates, and removes crust, fibrous root and silt, dries or low temperature is in dry.【Nature and flavor and channel tropism】It is bitter, sweet, it is slightly cold.Return lung, the heart channel of Hang-Shaoyin.
【Function is with curing mainly】Clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.For lung-heat type cough, the few phlegm of dry cough, deficiency of Yin overstrain cough coughs sputum streaked with blood.【Usage with
Consumption】3~9g, levigation is taken after mixing it with water, a 1~2g.【Note】Should not be with monkshood, aconiti preparata,radix, radix aconiti agrestis, wild aconite root, monkshood with use.
The wind-weed：For liliaceous plant wind-weed Anemarrhena asphodeloides Bge. dry rhizome.Spring, autumn two
Season excavates, and removes fibrous root and silt, dries, and practises and claims " RHIZOMA ANEMARRHENAE with peet "；Or crust is removed, dry.Nature and flavor and channel tropism】It is bitter, sweet, tremble with fear.
Return lung, stomach, kidney channel.【Function is with curing mainly】Clearing heat-fire, nourishing Yin and moistening dryness.For fever caused by exogenous pathogenic factors, hyperpyrexia polydipsia, lung-heat type cough, bone
Steam hectic fever, Heat Diabetes, dry constipation of intestines.
The root bark of white mulberry：For moraceae plants mulberry Morus alba L. dry root skin.Last years in autumn fall excavates up to before secondary spring germination
Root, scrapes off yellowish-brown tertia, longitudinally splits, strip root skin, dry.【Nature and flavor and channel tropism】It is sweet, tremble with fear.Return lung is passed through.【Function and master
Control】Removing heat from lung and relieving asthma, inducing diuresis for removing edema.For dyspnea and cough due to lung-heat, oedema turgor oliguria, appearance skin edema.
Gypsum：For Sulfates mineral anhydrite race gypsum, main (CaS042H2O) containing hydrous calcium sulfate after excavation, is removed
Impurity elimination stone and silt.【Nature and flavor and channel tropism】It is sweet, pungent, Great Cold.Attach to the lung and stomach meridians.【Function is with curing mainly】Clearing heat-fire, relieving restlessness is quenched the thirst.
For fever caused by exogenous pathogenic factors, hyperpyrexia polydipsia, dyspnea and cough due to lung-heat, the high Sheng of stomach fire is had a headache, toothache.
Radix glycyrrhizae：For glycyrrhizic legume Glycyrrhiza uralensis Fisch., swollen fruit Radix Glycyrrhiza
Inflate Bat. or glycyrrhiza glabra Glycyrrhiza glabra L. dry root and rhizome.Spring, season in autumn two excavation is removed
Fibrous root, is dried.【Nature and flavor and channel tropism】It is sweet, put down.The thoughts of returning home, lung, spleen, stomach.【Function is with curing mainly】Invigorate the spleen and benefit qi, it is clearing heat and detoxicating, dispel
Phlegm and relieving cough, relieving spasm to stop pain, coordinating the drug actions of a prescription.For weakness of the spleen and the stomach, lassitude hypodynamia, palpitation, coughing with a lot of sputum, gastral cavity abdomen, four limbs contraction
Anxious pain, carbuncle sore tumefacting virus alleviate drug toxicity, strong.
Another aspect of the present invention there is provided the preparation method of the active component of Chinese medicine composition of the present invention, and this method is
Extracted using the ethanol of water extraction or 40-80% concentration expressed in percentage by volume.Specific preparation method is as follows：
Scheme one：Take whole medicinal materials, extracting in water 2-3 times, each amount of water is equivalent to 6-12 times of medicinal material gross weight, often
Secondary extraction time is 1-3 hours, merges extract solution, is filtered, and relative density is 1.10-1.25's when filtrate is concentrated into 70-80 DEG C
Clear cream, produces active component.
Scheme two：Take whole medicinal materials, extracting in water 2-3 times, each amount of water is equivalent to 6-12 times of medicinal material gross weight, often
Secondary extraction time is 1-3 hours, merges extract solution, is filtered, and relative density is 1.05-1.20's when filtrate is concentrated into 70-80 DEG C
Clear cream, adds ethanol, and it is 40-70% to make alcohol content, stands 12-24 hours, filtration, and filtrate is concentrated into relatively close at 70-80 DEG C
The medicinal extract for 1.10-1.25 is spent, active component is produced.
Scheme three：Whole medicinal materials are taken, are extracted 2-3 times with 40-80% alcohol refluxs, each ethanol consumption is medicinal material total amount
4-10 times, extraction time is 1-3 hours, merges extract solution, is filtered, and relative density is 1.10- when filtrate is concentrated into 60-80 DEG C
1.25 medicinal extract, produces active component.
The treatment snorting Chinese medicine composition of pig of the present invention, can make with pharmaceutically acceptable carrier combination
Into various common dosage forms, such as tablet, granule, capsule, syrup.
The pharmaceutically acceptable carrier of the present invention includes but is not limited to following：
Diluent：Starch, Icing Sugar, lactose, dextrin, microcrystalline cellulose, inorganic salts, glycitols etc..
Wetting agent and adhesive：Purified water, ethanol, gelatin, polyethylene glycol, cellulose derivative etc..
Disintegrant：Starch, sodium carboxymethyl starch, cellulose derivative, PVPP etc..
Lubricant：Magnesium stearate, superfine silica gel powder, talcum powder, polyethylene glycol etc..
Cosolvent：Water, ethanol, glycerine, propane diols, liquid paraffin, vegetable oil etc..
Flavouring：Sucrose, monose, aromatic etc..
Preservative：Benzoic acid, sorbic acid, methyl esters, ethyl ester, propyl ester etc..
Chinese ephedra of the present invention freeings lung and relieving asthma, semen armeniacae amarae sending down abnormally ascending is relieving cough and asthma；Radix scutellariae heat-clearing and damp-drying drug；Orange quenches the thirst moistening lung；Balloonflower root
Facilitaing lung relieving sore-throat eliminating the phlegm；Fritillary bulb；Wind-weed clearing heat-fire, nourishing Yin and moistening dryness；Root bark of white mulberry removing heat from lung and relieving asthma；Gypsum clearing heat-fire, relieving restlessness stops
Yearningly；Radix glycyrrhizae is invigorated the spleen and benefited qi, clearing heat and detoxicating.Full side's collocation of the invention is scientific and reasonable, and heat in energy is clear rushes down pathogenic fire, a surname and opens lung qi, puts down
Breathe heavily, invigorate the spleen and benefit qi, make because the pig that the criminal's of warm lung is led to various symptoms of breathing rapidly disappear.
One kind that the present invention is provided, which treats the snorting Chinese medicine composition of pig, has advantages below：
1st, heat in the Chinese medicine composition energy of the invention provided is clear, rushes down pathogenic fire, a surname and opens lung qi, relieving asthma, invigorate the spleen and benefit qi, make Yin Wen
Heat is violated the pig that leads to of lung various symptoms of breathing and rapidly disappeared.Result in clinical application is shown：Disease can be effectively mitigated or eliminated in the present invention
The cough of pig and asthma symptom, are simple and easy to do, safely and effectively treatment methods.The high, medium and low dosage group pair of the embodiment of the present invention
The total effective rate of mycoplasma pneumonia of swine is respectively 95%, 90%, 70%, it was demonstrated that therapeutic effect of the present invention is extremely notable.
2nd, the present invention allows cough and asthma symptom to rapidly disappear by taking treatment by Chinese herbs, with safety, thoroughly, conveniently,
Economic advantage.
Embodiment
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are to be used to illustrate
The present invention rather than limitation of the present invention.The present invention is belonged to according to the simple modifications that the essence of the present invention is carried out to the present invention
Claimed scope.Unless otherwise indicated, the percentage of the amount of alcohol in the present invention is percentage by volume, and v/v represents solution
Volume ratio.
Embodiment 1：
Take Chinese ephedra 50g, semen armeniacae amarae 30g, radix scutellariae 25g, orange 30g, balloonflower root 30g, fritillary bulb 30g, wind-weed 30g, the root bark of white mulberry
30g, gypsum 100g, radix glycyrrhizae 20g, extracting in water 2 times, amount of water is respectively 10 times of medicinal material gross weight, 8 times twice, is carried twice
It is respectively 2 hours, 1 hour to take the time, merges extract solution, filtration, filtrate concentration is 1 times of medicinal material total amount, produces decoction.
Embodiment 2：
Take Chinese ephedra 40g, semen armeniacae amarae 25g, radix scutellariae 20g, orange 25g, balloonflower root 25g, fritillary bulb 25g, wind-weed 25g, the root bark of white mulberry
25g, gypsum 80g, radix glycyrrhizae 15g, are extracted 3 times with 40% alcohol reflux, and each ethanol consumption is respectively 10 times of medicinal material total amount, 8
Again, 4 times, extraction time is distinguished 3 hours, 2 hours, 1 hour, merges extract solution, filtering, relative density when filtrate is concentrated into 60 DEG C
For 1.25 medicinal extract, supplementary product starch, ethanol, talcum powder are added, tablet is made.
Embodiment 3：
Take Chinese ephedra 60g, semen armeniacae amarae 35g, radix scutellariae 30g, orange 35g, balloonflower root 35g, fritillary bulb 35g, wind-weed 35g, the root bark of white mulberry
35g, gypsum 120g, radix glycyrrhizae 25g, extracting in water 3 times, three amount of water be respectively equivalent to 12 times of medicinal material gross weight, 8 times, 6
Times, each extraction time is distinguished 3 hours, 2 hours, 1 hour, merges extract solution, filtration, relative density when filtrate is concentrated into 70 DEG C
For 1.20 clear cream, ethanol is added, it is 40% to make alcohol content, stands 24 hours, filtration, relative density when filtrate is concentrated into 70 DEG C
For 1.10 medicinal extract, addition purified water ad pond om is 3 times of medicinal material gross weight, filling, produces mixture of the present invention.
Embodiment 4：
Take Chinese ephedra 50g, semen armeniacae amarae 25g, radix scutellariae 30g, orange 30g, balloonflower root 25g, fritillary bulb 35g, wind-weed 30g, the root bark of white mulberry
25g, gypsum 120g, radix glycyrrhizae 20g, are extracted 2 times, each concentration of alcohol is respectively 80%, 60% with alcohol reflux, and each ethanol is used
Amount is respectively 10 times, 8 times of medicinal material total amount, and extraction time is respectively 4 hours, 3 hours, merges extract solution, filtering, filtrate concentration
To the medicinal extract that relative density at 80 DEG C is 1.10, supplementary product starch, ethanol, talcum powder are added, tablet is made.
Embodiment 5：
Take Chinese ephedra 40g, semen armeniacae amarae 35g, radix scutellariae 25g, orange 25g, balloonflower root 35g, fritillary bulb 30g, wind-weed 25g, the root bark of white mulberry
35g, gypsum 100g, radix glycyrrhizae 15g, extracting in water 3 times, three amount of water are respectively 12 times of medicinal material gross weight, 8 times, 6 times, three
Secondary extraction time is respectively 3 hours, 2 hours, 1 hour, merges extract solution, is filtered, relative density is when filtrate is concentrated into 70 DEG C
1.25 clear cream, adds supplementary product starch, ethanol, dextrin, magnesium stearate, loads capsule shells, capsule is made.
Embodiment 6：
Take Chinese ephedra 60g, semen armeniacae amarae 25g, radix scutellariae 25g, orange 35g, balloonflower root 25g, fritillary bulb 30g, wind-weed 35g, the root bark of white mulberry
25g, gypsum 80g, radix glycyrrhizae 25g, extracting in water 2 times, each amount of water are respectively equivalent to 12 times of medicinal material gross weight, 10 times, often
Secondary extraction time is respectively 3 hours, 2 hours, merges extract solution, filtration, it is 1.05 that filtrate, which is concentrated into relative density at 80 DEG C,
Clear cream, adds ethanol, and it is 70% to make alcohol content, stands 12 hours, filtration, and relative density is 1.25 when filtrate is concentrated into 70 DEG C
Medicinal extract, adds auxiliary material Icing Sugar, starch, dextrin, ethanol, and granule is made.
Embodiment 7：
Weigh Chinese ephedra 50g, semen armeniacae amarae 25g, radix scutellariae 25g, orange 35g, balloonflower root 30g, fritillary bulb 25g, the wind-weed 30g, Sang Bai
Skin 35g, gypsum 100g, radix glycyrrhizae 15g, extracting in water 2 times, amount of water is respectively 10 times of medicinal material gross weight, 8 times twice, twice
Extraction time is respectively 2 hours, 1 hour, merges extract solution, is filtered, and relative density is 1.10 leaching when filtrate is concentrated into 80 DEG C
Cream.Syrup auxiliary material sucrose, sorbic acid, water are added in medicinal extract to stir, and syrup is made.
Embodiment 8：
Weigh Chinese ephedra 50g, semen armeniacae amarae 30g, radix scutellariae 25g, orange 30g, balloonflower root 30g, fritillary bulb 30g, the wind-weed 30g, Sang Bai
Skin 30g, gypsum 100g, radix glycyrrhizae 20g, are cleaned, and are crushed, are produced pulvis of the present invention.
Clinical treatment is summarized
1 materials and methods
1.1 test material
1.1.1 the decoction of the test drug embodiment of the present invention 1
1.1.2 experimental animal collects 5 batches of pigs in Guangxi large―scale hoggery
The natural cases pig for having the doubtful mycoplasma pneumonia of swine disease of obvious clinical symptoms amounts to 90, and its symptom is：Sneeze, cough
Cough, pant, it is short cough, continuity length is coughed and dry cough；Breathing shows as abdominal respiration, or " dog is horizontal " posture is presented in sick pig；Spirit
It is depressed, slow-witted vertical；Loss of appetite.The age in days of pig is 40-45 days, after clinical definite, and positive sick pig 80 is selected by test requirements document
" it is divided into 4 groups, every group 20 for test pig.
1.2 test method
1.2.1 doubtful mycoplasma pneumonia of swine is made a definite diagnosis
1.2.1.1 clinical observation is with checking.Sick pig body temperature reaches more than 40 DEG C, and lassitude sends overcast dry cough, exhaled
It is in continuous spasmodic cough to be sat during suction in dog in shape, feed way, and expiratory dyspnea, respiration rate reaches 90-100 times/min, seriously
When mouth breathing.
1.2.1.2 serodiagnosis.Whole pigs blood sampling separation serum, go out can after carry out microparticle agglutination reaction, method and sentence
Calibration standard is with reference to " diagnosis and firm mycoplasma hyopneumoniae of the observation microparticle agglutination reaction to porcine enzootic pneumonia under the microscope
Research " method.
1.2.1.3X photodynamic diagnosis.Whole pigs carry out x-ray fluoroscopy film makings, and uprightly to carry on the back based on chest position, supplemented by the position of side, perspective is sentenced
Disconnected standard is provided by national mycoplasmal pneumonia Harbin meeting："-" cardiopulmonary are without visible shadow；There is partial phantom at "+" septum cordis angle；
" ++ " shaded region is larger, but heart circle is still visible；" +++ " heart circle is unclear.
1.2.1.4 pathology cut open inspection.Random cut open inspection sick dead pig, it is possible to find lung has different degrees of oedema and wind-puff, occurs disease
It is in pale red to become position, and substantially, apex pulmonis leaf is in typical " meat sample " consolidation, hilus pulumonis and the notable enlargement of vertical phrenic lymph nodes to boundary, is had
Inflammatory exudate, and organize and lymphocytosis.
1.2.1.5 laboratory diagnosis.Plate coating checking：The tangent plane of sick pig pulmonary lesionses and healthy lung tissue intersection is taken,
Smear is made of the slide of clean dry, after spontaneously drying several minutes, 3min is fixed with methanol, is delayed with pH7.2 phosphate
Ji's nurse Sa Albert'stain Albert liquid dyeing 3h that fliud flushing dilutes 20 times is rinsed, and 1 time, microscopy are embathed with acetone soln immediately after drying, it is seen that
There is the polymorphic microorganism such as purple ring-type, colyliform, spherical.
1.2.1.6 mycoplasma pneumonia of swine is made a definite diagnosis.According to epidemiology survey, there is Mycoplasmal pneumonia morbidity in sick pig
History, therefore this time morbid pig is very big for the possibility of mycoplasmal pneumonia：The sick pig of all collections, clinical onset symptom is obvious,
Major respiratory symptom is cough and pants, and morning and evening feeding is particularly evident, and sick pig is stood during cough, and rear arch is risen, and neck is stretched, under head
Hang down.Analyse pathological change result and show as typical lung (including hilar lymph node) tracheae and bronchus lesion (test in laboratory
Microparticle agglutination reaction result is more than " ++ "；X-ray fluoroscopy film making result is more than " ++ "；According to result above, disease is made a definite diagnosis
Pig infects disease of breathing.
1.2.2 therapeutic trial.After making a definite diagnosis, select immediately mycoplasma pneumonia of swine sick pig totally 80 (being presented with classical symptom) with
Machine is divided into 4 groups, and every group 20, medicine is given by packet, and the medication when there is disease symptom is administered three times a day, continuous to use
7 days as one therapeutic course.The clinical symptoms change of pig is observed in treatment in 1 week.
Experimental group 1：The decoction of embodiment 1 is given, by crude drug gauge, 200g/kg.
Experimental group 2：The decoction of embodiment 2 is given, by crude drug gauge, 100g/kg.
Experimental group 3：The decoction of embodiment 3 is given, by crude drug gauge, 50g/kg.
Blank group：It is not administered, observes.
1.2.3 index of assessment of curative effect
(1) inefficiency.During testing, there is the classical symptom of mycoplasma pneumonia of swine and dead, ptomatopsia has feature venereal disease
Change is defined as death.To have no that obvious improver is defined as invalid for the clinical symptoms of pig after drug treatment.According to dead pig and
The quantity of invalid pig calculates inefficiency.
(2) cure rate.During experiment drug treatment and observation, essence, appetite recover normal, mycoplasma pneumonia of swine after pig medication
Classical symptom disappearance person be defined as cure, cure rate is calculated according to the quantity of healing.
(3) it is efficient.During experiment drug treatment and observation, curing symptom after pig and administration has obvious alleviator,
It is determined as effectively.Calculate accordingly efficient.
2 results are with discussing
The cure rate of each test group, effective percentage, inefficiency are shown in Table 1.By table 1
Understand, using effective percentage as evaluation index, high, medium and low dosage group of the invention control group is not administered with morbidity pig is breathed heavily
The therapeutic effect difference of gas disease is extremely notable.The high, medium and low dosage group of the embodiment of the present invention is respectively to the effective percentage of mycoplasma pneumonia of swine
95%th, 90%, 70%.High dose group therapeutic effect of the present invention is especially notable.
The test group efficacy result of the present invention of table 1
| Cure rate (%) | Efficient (%) | Inefficiency (%) | |
| Blank control group | 0 | 0 | 100 |
| Test 1 group | 85* | 95* | 5 |
| Test 2 groups | 80* | 90* | 10 |
| Test 3 groups | 60* | 70* | 30 |
Note：Compared with blank control group, * P ＜ 0.01.
To the snorting emergency treatment of pig, if using Western medicine antibiotic therapy, once forming indication, antibacterial in swinery
In the case that extract for treating is invalid, large quantities of dead situations occur in swinery.Will not then occur drug resistance easily using treatment by Chinese herbs
Situation.So all advocate not use antibiotic when being avoided that as far as possible.By taking treatment by Chinese herbs, with safety, thoroughly, conveniently,
Economic advantage.
Although above having made to retouch in detail to the present invention with general explanation, embodiment and experiment
State, but on the basis of the present invention, it can be made some modifications or improvements, this is apparent to those skilled in the art
's.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, are belonged to claimed
Scope.
Claims (6)
1. one kind treats the snorting Chinese medicine composition of pig, it is characterised in that it is prepared from by the raw material of following parts by weight：
50 parts of Chinese ephedra, 30 parts of semen armeniacae amarae, 25 parts of radix scutellariae, 30 parts of orange, 30 parts of balloonflower root, 30 parts of fritillary bulb, 30 parts of the wind-weed, the root bark of white mulberry 30
Part, 100 parts of gypsum, 20 parts of radix glycyrrhizae.
2. Chinese medicine composition as claimed in claim 1, it is characterised in that its active component is to use water extraction or 40-80%
The ethanol of concentration expressed in percentage by volume extracts what is be prepared from.
3. Chinese medicine composition as claimed in claim 2, it is characterised in that its active component be prepared by the following method and
Into：Take whole medicinal materials, extracting in water 2-3 times, each amount of water is equivalent to 6-12 times of medicinal material gross weight, when extracting every time
Between be 1-3 hour, merge extract solution, filtration, when filtrate is concentrated into 70-80 DEG C relative density for 1.10-1.25 clear cream, i.e.,
Obtain the active component.
4. Chinese medicine composition as claimed in claim 2, it is characterised in that its active component be prepared by the following method and
Into：Take whole medicinal materials, extracting in water 2-3 times, each amount of water is equivalent to 6-12 times of medicinal material gross weight, when extracting every time
Between be 1-3 hour, merge extract solution, filtration, when filtrate is concentrated into 70-80 DEG C relative density for 1.05-1.20 clear cream, plus
Enter ethanol, it is 40-70% to make alcohol content, stands 12-24 hours, filtration, and relative density is when filtrate is concentrated into 70-80 DEG C
1.10-1.25 medicinal extract, produce the active component.
5. Chinese medicine composition as claimed in claim 2, it is characterised in that its active component be prepared by the following method and
Into：Whole medicinal materials are taken, are extracted 2-3 times with 40-80% alcohol refluxs, each ethanol consumption is 4-10 times of medicinal material total amount, is carried
It is 1-3 hours to take the time, merges extract solution, is filtered, and relative density is 1.10-1.25 leaching when filtrate is concentrated into 60-80 DEG C
Cream, produces the active component.
6. one kind treats the snorting Chinese medicine composition of pig, as treating the snorting Chinese medicine composition of pig and medicine described in claim 1
Acceptable carrier combination is prepared in industry.
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| CN101658660A (en) * | 2009-09-18 | 2010-03-03 | 天津诺康动物药业有限公司 | Traditional Chinese medicine composition for treating mycoplasmal pneumonia of swine and preparation method thereof |
| CN102188597A (en) * | 2011-05-03 | 2011-09-21 | 赵志敏 | Medicament of pure traditional Chinese medicine for treating swine enzootic pneumonia |
| CN102247565A (en) * | 2010-12-16 | 2011-11-23 | 桑立功 | Prescription for cough relieving and lung-heat clearing |
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| CN102512540B (en) * | 2011-12-23 | 2013-11-13 | 王学峰 | Chinese medicine composition for treating asthma |
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| CN101658660A (en) * | 2009-09-18 | 2010-03-03 | 天津诺康动物药业有限公司 | Traditional Chinese medicine composition for treating mycoplasmal pneumonia of swine and preparation method thereof |
| CN102247565A (en) * | 2010-12-16 | 2011-11-23 | 桑立功 | Prescription for cough relieving and lung-heat clearing |
| CN102188597A (en) * | 2011-05-03 | 2011-09-21 | 赵志敏 | Medicament of pure traditional Chinese medicine for treating swine enzootic pneumonia |
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